prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Cdk5rap1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Cdk5rap1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cdk5rap1 (CDK5 regulatory subunit associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, mitochondrial tRNA modification, negative regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of mitochondrial translation, positive regulation of translational fidelity, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of protein metabolic process, tRNA methylthiolation, tRNA modification, tRNA processing; MF: 4 iron, 4 sulfur cluster binding, catalytic activity, iron-sulfur cluster binding, metal ion binding, methylthiotransferase activity, protein-containing complex binding, tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity, transferase activity; CC: cytosol, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways:
UniProt: Q8BTW8
Entrez ID: 66971
|
Does Knockout of Uba3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Uba3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Uba3 (ubiquitin-like modifier activating enzyme 3)
Type: protein-coding
Summary: The protein encoded by this gene is the catalytic subunit of the enzyme that activates NEDD8, a ubiquitin-like molecule that binds to its target proteins through an enzymatic reaction analagous to ubiquitylation. Embryonic mice deficient for this protein die prior to implantation and display apoptosis of the inner cell mass. Trophoblastic cells cannot enter S phase, demonstrating that this gene is required for cell cycle progression during embryogenesis. Two pseudogenes have been found for this gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: endomitotic cell cycle, mitotic cell cycle, negative regulation of DNA-templated transcription, protein neddylation, regulation of cell cycle; MF: ATP binding, NEDD8 activating enzyme activity, identical protein binding, ligase activity, nuclear receptor binding, nucleotide binding, protein binding, protein heterodimerization activity, protein-containing complex binding, ubiquitin-like modifier activating enzyme activity; CC: cytoplasm, nucleus, protein-containing complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Immune System, Innate Immune System, Metabolism of proteins, NIK-->noncanonical NF-kB signaling, Neddylation, Post-translational protein modification, TNFR2 non-canonical NF-kB pathway, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8C878
Entrez ID: 22200
|
Does Knockout of Tmem216 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Tmem216
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tmem216 (transmembrane protein 216)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which is involved in regulation of signaling and trafficking of associated proteins. In humans, mutations in this gene are associated with ciliopathies including Joubert, Meckel and related syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: cell projection organization, cilium assembly, non-motile cilium assembly; CC: MKS complex, cell projection, ciliary transition zone, cilium, cytoplasm, cytoskeleton, membrane
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q9CQC4
Entrez ID: 68642
|
Does Knockout of Vgll1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Vgll1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vgll1 (vestigial like family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q99NC0
Entrez ID: 170828
|
Does Knockout of Siva1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Siva1
|
cell cycle progression
|
breast epithelium
|
Gene: Siva1 (SIVA1, apoptosis-inducing factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell apoptotic process, T cell receptor signaling pathway, activation-induced cell death of T cells, apoptotic process, extrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway, negative regulation of canonical NF-kappaB signal transduction, positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, symbiont entry into host cell; MF: CD27 receptor binding, metal ion binding, tumor necrosis factor receptor binding, virus receptor activity, zinc ion binding; CC: cytoplasm, mitochondrion, nucleoplasm, nucleus
Pathways: p53 signaling pathway - Mus musculus (mouse)
UniProt: O54926
Entrez ID: 30954
|
Does Knockout of Tbr1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Tbr1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tbr1 (T-box brain transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amygdala development, cell fate specification, cerebral cortex development, chromatin remodeling, commitment of neuronal cell to specific neuron type in forebrain, conditioned taste aversion, forebrain neuron differentiation, gene expression, hindbrain development, negative regulation of DNA-templated transcription, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of axon guidance, regulation of gene expression, regulation of neuron projection development, regulation of transcription by RNA polymerase II, specification of animal organ identity; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, protein kinase binding; CC: chromatin, nucleus
Pathways:
UniProt: Q64336
Entrez ID: 21375
|
Does Knockout of Ssxb2 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Ssxb2
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Ssxb2 (SSX member B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C5Z3, Q80ZT4
Entrez ID: 387132
|
Does Knockout of Paqr9 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Paqr9
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Paqr9 (progestin and adipoQ receptor family member IX)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: lipid binding, signaling receptor activity, steroid binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q6TCG2
Entrez ID: 75552
|
Does Knockout of Sugt1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Sugt1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Sugt1 (SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: kinetochore assembly, regulation of protein stability, skeletal muscle satellite cell proliferation, spindle organization; MF: lncRNA binding, protein-folding chaperone binding; CC: cytoplasm, cytosol, kinetochore, nuclear body, nucleus, protein-containing complex
Pathways: Immune System, Inflammasomes, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, The NLRP3 inflammasome
UniProt: Q9CX34
Entrez ID: 67955
|
Does Knockout of Maged1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Maged1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Maged1 (MAGE family member D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian regulation of gene expression, negative regulation of DNA-templated transcription, negative regulation of epithelial cell proliferation, negative regulation of protein localization to nucleus, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of MAP kinase activity, positive regulation of apoptotic signaling pathway, positive regulation of branching involved in ureteric bud morphogenesis, regulation of circadian rhythm, regulation of transcription by RNA polymerase II, rhythmic process; MF: identical protein binding, protein binding, transcription coactivator activity; CC: chromatin, cytoplasm, cytosol, membrane, nucleus, plasma membrane, protein-containing complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, NPAS4 regulates expression of target genes, Neurotrophin signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Transcriptional Regulation by NPAS4
UniProt: Q9QYH6
Entrez ID: 94275
|
Does Knockout of Snw1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Snw1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Snw1 (SNW domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cellular response to retinoic acid, host-mediated activation of viral transcription, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, mRNA processing, mRNA splicing, via spliceosome, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of mRNA splicing, via spliceosome, positive regulation of neurogenesis, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of vitamin D receptor signaling pathway, regulation of retinoic acid receptor signaling pathway, regulation of vitamin D receptor signaling pathway, retinoic acid receptor signaling pathway, skeletal muscle cell differentiation; MF: Notch binding, SMAD binding, enzyme binding, nuclear androgen receptor binding, nuclear receptor binding, nuclear retinoic acid receptor binding, nuclear vitamin D receptor binding, protein binding, transcription coactivator activity, transcription corepressor activity; CC: SMAD protein complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, chromatin, cyclin/CDK positive transcription elongation factor complex, nuclear body, nuclear matrix, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Downregulation of SMAD2/3:SMAD4 transcriptional activity, Epstein-Barr virus infection - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, NOTCH1 Intracellular Domain Regulates Transcription, Notch signaling pathway - Mus musculus (mouse), Notch-HLH transcription pathway, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RUNX3 regulates NOTCH signaling, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Spliceosome - Mus musculus (mouse), Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation by RUNX3, Viral carcinogenesis - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9CSN1
Entrez ID: 66354
|
Does Knockout of Arid1b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Arid1b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Arid1b (AT-rich interaction domain 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, dendritic cell dendrite assembly, dendritic spine development, nervous system development, neuron-neuron synaptic transmission, positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, nucleosome binding, protein binding; CC: SWI/SNF complex, brahma complex, cytosol, nBAF complex, nucleoplasm, nucleus, plasma membrane, synapse
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: E9Q4N7
Entrez ID: 239985
|
Does Knockout of Mmp20 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Mmp20
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mmp20 (matrix metallopeptidase 20 (enamelysin))
Type: protein-coding
Summary: This gene encodes a member of the matrix metalloproteinase family of zinc-dependent endopeptidases capable of degrading extracellular matrix proteins. This gene is expressed specifically in the ameloblasts and odontoblasts, and the encoded protein is an inactive zymogen that requires proteolytic removal of a N-terminal propeptide to become enzymatically active. Mice lacking the encoded protein display an amelogenesis imperfecta phenotype. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: amelogenesis, collagen catabolic process, extracellular matrix disassembly, extracellular matrix organization, protein catabolic process, proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular region
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Extracellular matrix organization
UniProt: P57748
Entrez ID: 30800
|
Does Knockout of Scmh1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Scmh1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Scmh1 (Scm polycomb group homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, chromatin remodeling, heterochromatin formation, negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, spermatogenesis; MF: chromatin binding, histone binding, protein binding; CC: chromocenter, male germ cell nucleus, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of RNA binding proteins, SUMOylation of chromatin organization proteins, SUMOylation of transcription cofactors, Transcriptional regulation by RUNX1
UniProt: Q8K214
Entrez ID: 29871
|
Does Knockout of Ints9 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,266
|
Knockout
|
Ints9
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ints9 (integrator complex subunit 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, regulation of cellular response to growth factor stimulus, snRNA 3'-end processing, snRNA processing; CC: INTAC complex, cytoplasm, cytosol, integrator complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q8K114
Entrez ID: 210925
|
Does Knockout of Zfp800 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Zfp800
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Zfp800 (zinc finger protein 800)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acinar cell differentiation, endocrine pancreas development; MF: DNA binding, metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q0VEE6
Entrez ID: 627049
|
Does Knockout of Rbm46 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Rbm46
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rbm46 (RNA binding motif protein 46)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell cycle switching, mitotic to meiotic cell cycle, cell differentiation, female meiotic nuclear division, mRNA stabilization, male meiotic nuclear division, meiotic cell cycle, oogenesis, spermatid differentiation, spermatogenesis, trophectodermal cell differentiation; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, nucleus
Pathways:
UniProt: P86049
Entrez ID: 633285
|
Does Knockout of Fam76a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Fam76a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fam76a (family with sequence similarity 76, member A)
Type: protein-coding
Summary: Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Is expressed in embryo. Orthologous to human FAM76A (family with sequence similarity 76 member A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: nuclear speck, nucleoplasm
Pathways:
UniProt: Q922G2
Entrez ID: 230789
|
Does Knockout of Gria3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Gria3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gria3 (glutamate receptor, ionotropic, AMPA3 (alpha 3))
Type: protein-coding
Summary: This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: calcium-mediated signaling, ionotropic glutamate receptor signaling pathway, long-term synaptic potentiation, modulation of chemical synaptic transmission, monoatomic ion transmembrane transport, monoatomic ion transport, protein heterotetramerization, protein homotetramerization, regulation of postsynaptic membrane potential, regulation of presynaptic membrane potential, regulation of receptor recycling, synaptic transmission, glutamatergic; MF: AMPA glutamate receptor activity, amyloid-beta binding, glutamate-gated calcium ion channel activity, glutamate-gated receptor activity, ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, monoatomic ion channel activity, protein binding, signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: AMPA glutamate receptor complex, asymmetric synapse, dendrite, dendritic shaft, dendritic spine, glutamatergic synapse, membrane, neuronal cell body, parallel fiber to Purkinje cell synapse, perikaryon, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, presynaptic active zone membrane, presynaptic membrane, protein-containing complex, synapse, synaptic cleft, terminal bouton
Pathways: Activation of AMPA receptors, Activation of NMDA receptors and postsynaptic events, Amphetamine addiction - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Glutamatergic synapse - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Protein-protein interactions at synapses, Retrograde endocannabinoid signaling - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Synaptic adhesion-like molecules, Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transcriptional misregulation in cancer - Mus musculus (mouse), Transmission across Chemical Synapses, Unblocking of NMDA receptors, glutamate binding and activation, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q9Z2W9
Entrez ID: 53623
|
Does Knockout of Alg1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Alg1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Alg1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase)
Type: protein-coding
Summary: Predicted to enable chitobiosyldiphosphodolichol beta-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a positive effect on protein N-linked glycosylation. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: chitobiosyldiphosphodolichol beta-mannosyltransferase activity, glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: cytoplasmic side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Various types of N-glycan biosynthesis - Mus musculus (mouse), dolichyl-diphosphooligosaccharide biosynthesis
UniProt: Q921Q3
Entrez ID: 208211
|
Does Knockout of Zc3h12d in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Zc3h12d
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Zc3h12d (zinc finger CCCH type containing 12D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, mRNA catabolic process, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell proliferation, negative regulation of cell growth; MF: RNA endonuclease activity, endonuclease activity, hydrolase activity, mRNA binding, metal ion binding, nuclease activity, zinc ion binding; CC: P-body, cytoplasm, cytoplasmic ribonucleoprotein granule, nucleoplasm, nucleus
Pathways:
UniProt: Q8BIY3
Entrez ID: 237256
|
Does Knockout of Nin in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Nin
|
cell cycle progression
|
breast epithelium
|
Gene: Nin (ninein)
Type: protein-coding
Summary: Enables microtubule minus-end binding activity. Acts upstream of or within several processes, including axonogenesis; microtubule cytoskeleton organization; and positive regulation of axonogenesis. Located in several cellular components, including axonal growth cone; dendrite; and microtubule cytoskeleton. Part of ciliary transition fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in Seckel syndrome 7. Orthologous to human NIN (ninein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: centriole-centriole cohesion, centrosome localization, centrosome-templated microtubule nucleation, collateral sprouting, corpus callosum morphogenesis, corticospinal tract morphogenesis, intracellular protein localization, microtubule anchoring at centrosome, mitotic spindle organization, negative regulation of protein localization to centrosome, positive regulation of axonogenesis, positive regulation of neuron differentiation; MF: GTP binding, calcium ion binding, microtubule minus-end binding, nucleotide binding, protein binding; CC: apical part of cell, axon, axonal growth cone, centriolar subdistal appendage, centriole, centrosome, ciliary basal body, ciliary transition fiber, cytoplasm, cytoplasmic microtubule, cytoskeleton, cytosol, dendrite, microtubule, mitotic spindle, mitotic spindle pole, nucleolus, nucleoplasm, pericentriolar material, plasma membrane, spindle pole
Pathways:
UniProt: Q61043
Entrez ID: 18080
|
Does Knockout of H2-M11 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
H2-M11
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: H2-M11 (histocompatibility 2, M region locus 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, antigen processing and presentation of peptide antigen via MHC class I, immune response, immune system process, positive regulation of T cell mediated cytotoxicity; MF: peptide antigen binding, signaling receptor binding; CC: MHC class I protein complex, external side of plasma membrane, extracellular space, lumenal side of endoplasmic reticulum membrane, membrane, phagocytic vesicle membrane
Pathways: Allograft rejection - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: Q85ZX0
Entrez ID: 224754
|
Does Knockout of Icam4 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Icam4
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Icam4 (intercellular adhesion molecule 4, Landsteiner-Wiener blood group)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion; MF: integrin binding; CC: cytoplasm, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Adaptive Immune System, Extracellular matrix organization, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Integrin cell surface interactions
UniProt: Q9ERM2
Entrez ID: 78369
|
Does Knockout of Khsrp in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Khsrp
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Khsrp (KH-type splicing regulatory protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, RNA splicing, cellular response to cytokine stimulus, mRNA catabolic process, mRNA processing, mRNA transport, miRNA metabolic process, negative regulation of low-density lipoprotein particle clearance, negative regulation of nitric oxide biosynthetic process, positive regulation of mRNA catabolic process, regulation of DNA-templated transcription, regulation of mRNA stability, regulation of miRNA metabolic process, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA binding, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding, protein folding chaperone; CC: cytoplasm, cytoplasmic stress granule, cytosol, dendrite, neuronal cell body, nucleoplasm, nucleus
Pathways: KSRP (KHSRP) binds and destabilizes mRNA, Metabolism of RNA, Regulation of mRNA stability by proteins that bind AU-rich elements
UniProt: Q3U0V1
Entrez ID: 16549
|
Does Knockout of Cryba4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Cryba4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cryba4 (crystallin, beta A4)
Type: protein-coding
Summary: This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. Certain mutations in the human ortholog of this gene are associated with cataract and bilateral microphthalmia. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: camera-type eye development, eye development, lens development in camera-type eye, visual perception; MF: identical protein binding, structural constituent of eye lens
Pathways:
UniProt: Q9JJV0
Entrez ID: 12959
|
Does Knockout of Ppox in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Ppox
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ppox (protoporphyrinogen oxidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, porphyrin-containing compound biosynthetic process, protoporphyrinogen IX biosynthetic process, protoporphyrinogen IX metabolic process, response to xenobiotic stimulus; MF: oxidoreductase activity, oxygen-dependent protoporphyrinogen oxidase activity, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion
Pathways: Heme biosynthesis, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, heme biosynthesis from uroporphyrinogen-III I
UniProt: P51175
Entrez ID: 19044
|
Does Knockout of Fgd6 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Fgd6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fgd6 (FYVE, RhoGEF and PH domain containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, metal ion binding, molecular_function, zinc ion binding; CC: cytoplasm, cytoskeleton
Pathways:
UniProt: Q69ZL1
Entrez ID: 13998
|
Does Knockout of Sptlc1 in bone marrow cell line causally result in regulation of signal transduction phenotype?
| 1
| 1,785
|
Knockout
|
Sptlc1
|
regulation of signal transduction phenotype
|
bone marrow cell line
|
Gene: Sptlc1 (serine palmitoyltransferase, long chain base subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, regulation of fat cell apoptotic process, sphinganine biosynthetic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingomyelin biosynthetic process, sphingosine biosynthetic process; MF: acyltransferase activity, protein binding, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), ceramide biosynthesis
UniProt: O35704
Entrez ID: 268656
|
Does Knockout of Rmnd5a in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Rmnd5a
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Rmnd5a (required for meiotic nuclear division 5 homolog A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: GID complex, cytoplasm, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q80YQ8
Entrez ID: 68477
|
Does Knockout of Prr30 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Prr30
|
cell cycle progression
|
breast epithelium
|
Gene: Prr30 (proline rich 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D9B7
Entrez ID: 76627
|
Does Knockout of Sf3b3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Sf3b3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sf3b3 (splicing factor 3b, subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, negative regulation of protein catabolic process, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing; MF: U2 snRNA binding, nucleic acid binding, protein binding, protein-containing complex binding; CC: SAGA complex, U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q921M3
Entrez ID: 101943
|
Does Knockout of Cpb2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Cpb2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cpb2 (carboxypeptidase B2)
Type: protein-coding
Summary: This gene encodes carboxypeptidase B, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme, and secreted into plasma. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: blood coagulation, fibrinolysis, hemostasis, negative regulation of fibrinolysis, negative regulation of hepatocyte proliferation, negative regulation of plasminogen activation, positive regulation of extracellular matrix constituent secretion, protein catabolic process, proteolysis; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular region, extracellular space
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Immune System, Innate Immune System, Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Pancreatic secretion - Mus musculus (mouse), Peptide hormone metabolism, Protein digestion and absorption - Mus musculus (mouse), Regulation of Complement cascade
UniProt: Q9JHH6
Entrez ID: 56373
|
Does Knockout of Mir7064 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Mir7064
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mir7064 (microRNA 7064)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465644
|
Does Knockout of Lrit3 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Lrit3
|
response to bacteria
|
renal medulla cell line
|
Gene: Lrit3 (leucine-rich repeat, immunoglobulin-like and transmembrane domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gene expression, intracellular protein localization, regulation of fibroblast growth factor receptor signaling pathway, response to light stimulus, synapse assembly involved in innervation, synaptic signaling, visual perception; MF: molecular_function, protein binding; CC: cell projection, cell tip, cellular_component, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, perikaryon, synapse
Pathways:
UniProt: W8DXL4
Entrez ID: 242235
|
Does Knockout of Mcm9 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,539
|
Knockout
|
Mcm9
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Mcm9 (minichromosome maintenance 9 homologous recombination repair factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, double-strand break repair via homologous recombination, female gamete generation, gamete generation, mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication, protein localization to chromatin, recombinational interstrand cross-link repair; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, MutLbeta complex binding, MutSalpha complex binding, MutSbeta complex binding, chromatin binding, enzyme binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, protein-containing complex binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: MCM complex, MCM8-MCM9 complex, chromosome, nucleus
Pathways:
UniProt: Q2KHI9
Entrez ID: 71567
|
Does Knockout of Kcns2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Kcns2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Kcns2 (K+ voltage-gated channel, subfamily S, 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of potassium ion transmembrane transport, transmembrane transport; MF: monoatomic ion channel activity, potassium channel activity, potassium channel regulator activity, voltage-gated potassium channel activity; CC: membrane, monoatomic ion channel complex, perinuclear region of cytoplasm, plasma membrane, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: O35174
Entrez ID: 16539
|
Does Knockout of Cabp5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Cabp5
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Cabp5 (calcium binding protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium channel regulator activity, calcium ion binding, metal ion binding; CC: cytoplasm, cytosol
Pathways:
UniProt: Q9JLK3
Entrez ID: 29865
|
Does Knockout of Pcyox1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Pcyox1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pcyox1 (prenylcysteine oxidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, prenylated protein catabolic process, prenylcysteine catabolic process; MF: FAD binding, farnesylcysteine lyase activity, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor, prenylcysteine oxidase activity; CC: lysosome, very-low-density lipoprotein particle
Pathways: Terpenoid backbone biosynthesis - Mus musculus (mouse)
UniProt: Q9CQF9
Entrez ID: 66881
|
Does Knockout of Nav3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Nav3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nav3 (neuron navigator 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell migration, negative regulation of interleukin-2 production, negative regulation of microtubule depolymerization, nervous system development, neurogenesis, positive regulation of microtubule polymerization; MF: ATP binding, ATP hydrolysis activity, microtubule binding; CC: membrane, microtubule end, nuclear envelope, nuclear outer membrane, nucleus
Pathways:
UniProt: Q80TN7
Entrez ID: 260315
|
Does Knockout of Cldn5 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Cldn5
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Cldn5 (claudin 5)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a critical component of endothelial tight junctions that control pericellular permeability. The knockout mice lacking this gene died within 10 h of birth and the blood-brain barrier in these mice against small molecules was selectively affected. This gene is expressed strongly in endothelium of normal lung and plays a regulation role during acrolein-induced acute lung injury. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: bicellular tight junction assembly, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion, cell-cell adhesion, cell-cell junction assembly, establishment of blood-retinal barrier, maintenance of blood-brain barrier, myelination, negative regulation of angiogenesis, negative regulation of cell migration, negative regulation of gene expression, negative regulation of vascular permeability, positive regulation of bicellular tight junction assembly, positive regulation of cell population proliferation, positive regulation of establishment of endothelial barrier, positive regulation of gene expression, response to ethanol, tight junction assembly, transforming growth factor beta receptor signaling pathway; MF: identical protein binding, protein binding, structural molecule activity; CC: Schmidt-Lanterman incisure, anchoring junction, apicolateral plasma membrane, bicellular tight junction, cell-cell junction, cortical actin cytoskeleton, lateral plasma membrane, membrane, paranode region of axon, plasma membrane, tight junction
Pathways: Cell adhesion molecules - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: O54942
Entrez ID: 12741
|
Does Knockout of Fgr in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Fgr
|
response to bacteria
|
macrophage
|
Gene: Fgr (FGR proto-oncogene, Src family tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, cell differentiation, cell surface receptor protein tyrosine kinase signaling pathway, defense response to Gram-positive bacterium, immune system process, innate immune response, integrin-mediated signaling pathway, negative regulation of natural killer cell activation, peptidyl-tyrosine phosphorylation, positive regulation of cell migration, positive regulation of cytokine production, positive regulation of mast cell degranulation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of actin cytoskeleton organization, regulation of cell shape, regulation of innate immune response, regulation of phagocytosis, regulation of protein kinase activity, skeletal system morphogenesis; MF: ATP binding, Fc-gamma receptor I complex binding, immunoglobulin receptor binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphotyrosine residue binding, protein binding, protein kinase activity, protein kinase binding, protein tyrosine kinase activity, signaling receptor binding, transferase activity; CC: actin cytoskeleton, aggresome, cell projection, cytoplasm, cytoskeleton, cytosol, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, plasma membrane, ruffle membrane
Pathways: Chemokine signaling pathway - Mus musculus (mouse), FCGR activation, Fcgamma receptor (FCGR) dependent phagocytosis, Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation, Platelet homeostasis, Platelet sensitization by LDL
UniProt: P14234
Entrez ID: 14191
|
Does Knockout of Clasp1 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Clasp1
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Clasp1 (CLIP associating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, astral microtubule organization, basement membrane organization, cell division, cell migration, establishment of cell polarity, establishment of mitotic spindle localization, establishment of spindle orientation, exit from mitosis, microtubule anchoring, microtubule bundle formation, microtubule cytoskeleton organization, microtubule nucleation, microtubule organizing center organization, mitotic spindle assembly, mitotic spindle organization, negative regulation of microtubule depolymerization, negative regulation of microtubule polymerization or depolymerization, negative regulation of stress fiber assembly, negative regulation of wound healing, spreading of epidermal cells, positive regulation of epithelial cell migration, positive regulation of exocytosis, positive regulation of extracellular matrix disassembly, regulation of focal adhesion assembly, vesicle targeting; MF: dystroglycan binding, kinetochore binding, microtubule binding, microtubule plus-end binding, protein binding, tubulin binding; CC: Golgi apparatus, basal cortex, cell cortex, centrosomal corona, centrosome, chromosome, chromosome, centromeric region, cortical microtubule cytoskeleton, cytoplasm, cytoplasmic microtubule, cytoskeleton, focal adhesion, kinetochore, microtubule, microtubule cytoskeleton, microtubule organizing center, mitotic spindle, spindle, spindle microtubule
Pathways: AURKA Activation by TPX2, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, EML4 and NUDC in mitotic spindle formation, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Organelle biogenesis and maintenance, RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80TV8
Entrez ID: 76707
|
Does Knockout of Mir8098 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Mir8098
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Mir8098 (microRNA 8098)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465889
|
Does Knockout of Vmn1r215 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Vmn1r215
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Vmn1r215 (vomeronasal 1 receptor 215)
Type: protein-coding
Summary: Predicted to enable pheromone binding activity and pheromone receptor activity. Predicted to act upstream of or within response to pheromone. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R264
Entrez ID: 171253
|
Does Knockout of Krtap8-1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Krtap8-1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Krtap8-1 (keratin associated protein 8-1)
Type: protein-coding
Summary: Predicted to be located in cytosol and intermediate filament. Orthologous to human KRTAP8-1 (keratin associated protein 8-1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: O08633
Entrez ID: 16703
|
Does Knockout of Acap1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Acap1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Acap1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lipid catabolic process, lipid metabolic process, signal transduction; MF: GTPase activator activity, metal ion binding, molecular_function, zinc ion binding; CC: cytoplasm, endosome, membrane, recycling endosome membrane
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q8K2H4
Entrez ID: 216859
|
Does Knockout of Ptprc in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,528
|
Knockout
|
Ptprc
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ptprc (protein tyrosine phosphatase receptor type C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, B cell proliferation, B cell receptor signaling pathway, T cell differentiation, T cell proliferation, T cell receptor signaling pathway, bone marrow development, cell cycle phase transition, defense response to virus, dephosphorylation, hematopoietic progenitor cell differentiation, heterotypic cell-cell adhesion, leukocyte cell-cell adhesion, natural killer cell differentiation, negative regulation of ERK1 and ERK2 cascade, negative regulation of T cell mediated cytotoxicity, negative regulation of cell adhesion involved in substrate-bound cell migration, negative regulation of cytokine-mediated signaling pathway, negative regulation of interleukin-2 production, negative regulation of interleukin-4-mediated signaling pathway, negative regulation of protein kinase activity, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of transcription by RNA polymerase II, negative thymic T cell selection, plasma membrane raft distribution, positive regulation of B cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of Fc receptor mediated stimulatory signaling pathway, positive regulation of MAPK cascade, positive regulation of T cell differentiation, positive regulation of T cell mediated cytotoxicity, positive regulation of T cell mediated immunity, positive regulation of T cell proliferation, positive regulation of alpha-beta T cell proliferation, positive regulation of antigen receptor-mediated signaling pathway, positive regulation of calcium-mediated signaling, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of gamma-delta T cell differentiation, positive regulation of hematopoietic stem cell migration, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of immunoglobulin production, positive regulation of interleukin-2 production, positive regulation of isotype switching to IgG isotypes, positive regulation of phagocytosis, positive regulation of stem cell proliferation, positive regulation of tumor necrosis factor production, positive thymic T cell selection, protein dephosphorylation, regulation of T cell receptor signaling pathway, regulation of cell cycle, regulation of extrinsic apoptotic signaling pathway, regulation of gene expression, regulation of humoral immune response mediated by circulating immunoglobulin, regulation of interleukin-8 production, regulation of phagocytosis, release of sequestered calcium ion into cytosol, response to gamma radiation, signal transduction, stem cell development; MF: ankyrin binding, heparan sulfate proteoglycan binding, heparin binding, hydrolase activity, phosphoprotein phosphatase activity, protein binding, protein kinase binding, protein tyrosine kinase inhibitor activity, protein tyrosine phosphatase activity, signaling receptor binding, spectrin binding, transmembrane receptor protein tyrosine phosphatase activity; CC: bleb, cell periphery, cell surface, cytoplasmic side of plasma membrane, external side of plasma membrane, focal adhesion, membrane, membrane microdomain, membrane raft, plasma membrane, side of membrane, synapse
Pathways: Adaptive Immune System, Axon guidance, Cell adhesion molecules - Mus musculus (mouse), Developmental Biology, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Immune System, Innate Immune System, Nervous system development, Neutrophil degranulation, Other semaphorin interactions, Phosphorylation of CD3 and TCR zeta chains, Primary immunodeficiency - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Semaphorin interactions, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling
UniProt: P06800
Entrez ID: 19264
|
Does Knockout of Fam234a in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Fam234a
|
phagocytosis
|
macrophage
|
Gene: Fam234a (family with sequence similarity 234, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cell surface, membrane
Pathways:
UniProt: Q8C0Z1
Entrez ID: 106581
|
Does Knockout of Abl1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Abl1
|
cell proliferation
|
Regulatory T cell
|
Gene: Abl1 (c-abl oncogene 1, non-receptor tyrosine kinase)
Type: protein-coding
Summary: Enables several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; positive regulation of cell migration; and regulation of T cell activation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; lymphocyte differentiation; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; cell leading edge; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and leukemia (multiple). Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell proliferation, B cell proliferation involved in immune response, B cell receptor signaling pathway, B-1 B cell homeostasis, Bergmann glial cell differentiation, DN4 thymocyte differentiation, DNA conformation change, DNA damage response, DNA repair, T cell receptor signaling pathway, actin cytoskeleton organization, actin filament polymerization, activated T cell proliferation, alpha-beta T cell differentiation, apoptotic process, associative learning, autophagy, canonical NF-kappaB signal transduction, cardiac muscle cell proliferation, cell adhesion, cell-cell adhesion, cellular response to hydrogen peroxide, cellular response to lipopolysaccharide, cellular response to oxidative stress, cellular response to oxygen-containing compound, cellular response to stress, cellular response to transforming growth factor beta stimulus, cerebellum morphogenesis, circulatory system development, endocytosis, endothelial cell migration, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway, establishment of localization in cell, immune effector process, immune response-activating cell surface receptor signaling pathway, integrin-mediated signaling pathway, intracellular signal transduction, learning or memory, microspike assembly, myoblast proliferation, negative regulation of BMP signaling pathway, negative regulation of ERK1 and ERK2 cascade, negative regulation of cell-cell adhesion, negative regulation of cellular senescence, negative regulation of double-strand break repair via homologous recombination, negative regulation of endothelial cell apoptotic process, negative regulation of intracellular signal transduction, negative regulation of long-term synaptic potentiation, negative regulation of mitotic cell cycle, neural tube closure, neuroepithelial cell differentiation, neuromuscular process controlling balance, neuron differentiation, neuropilin signaling pathway, peptidyl-tyrosine phosphorylation, phagocytosis, phospholipase C-inhibiting G protein-coupled receptor signaling pathway, plasma membrane bounded cell projection assembly, platelet-derived growth factor receptor signaling pathway, platelet-derived growth factor receptor-beta signaling pathway, podocyte apoptotic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of T cell migration, positive regulation of Wnt signaling pathway, planar cell polarity pathway, positive regulation of apoptotic process, positive regulation of blood vessel branching, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cytosolic calcium ion concentration, positive regulation of dendrite development, positive regulation of endothelial cell migration, positive regulation of establishment of T cell polarity, positive regulation of extracellular matrix organization, positive regulation of fibroblast proliferation, positive regulation of focal adhesion assembly, positive regulation of interleukin-2 production, positive regulation of mitotic cell cycle, positive regulation of neuron apoptotic process, positive regulation of osteoblast proliferation, positive regulation of phospholipase C/protein kinase C signal transduction, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of stress fiber assembly, positive regulation of substrate adhesion-dependent cell spreading, positive regulation of type II interferon production, positive regulation of vasoconstriction, post-embryonic development, protein localization to cytoplasmic microtubule plus-end, protein phosphorylation, regulation of Cdc42 protein signal transduction, regulation of T cell differentiation, regulation of actin cytoskeleton organization, regulation of axon extension, regulation of biological quality, regulation of cell cycle, regulation of cell differentiation, regulation of cell population proliferation, regulation of cellular senescence, regulation of extracellular matrix organization, regulation of microtubule polymerization, regulation of modification of synaptic structure, regulation of postsynaptic specialization assembly, regulation of transport, response to endoplasmic reticulum stress, response to epinephrine, response to oxidative stress, response to xenobiotic stimulus, signal transduction in response to DNA damage, spleen development, substrate adhesion-dependent cell spreading, thymus development, transitional one stage B cell differentiation; MF: ATP binding, DNA binding, SH2 domain binding, actin binding, actin filament binding, bubble DNA binding, delta-catenin binding, enzyme activator activity, enzyme binding, ephrin receptor binding, four-way junction DNA binding, kinase activity, magnesium ion binding, manganese ion binding, metal ion binding, mitogen-activated protein kinase binding, neuropilin binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphotyrosine residue binding, proline-rich region binding, protein binding, protein domain specific binding, protein kinase C binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, sequence-specific double-stranded DNA binding, syntaxin binding, transferase activity; CC: actin cytoskeleton, cell leading edge, cytoplasm, cytoskeleton, cytosol, dendrite, glutamatergic synapse, growth cone, mitochondrion, neuron projection, neuronal cell body, nuclear body, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, protein-containing complex, ruffle
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Cyclin D associated events in G1, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Developmental Biology, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, ErbB signaling pathway - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, G1 Phase, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Innate Immune System, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, MicroRNAs in cancer - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Myogenesis, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Ras signaling pathway - Mus musculus (mouse), Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of actin dynamics for phagocytic cup formation, Response of endothelial cells to shear stress, Role of ABL in ROBO-SLIT signaling, Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by RUNX1, Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Viral myocarditis - Mus musculus (mouse)
UniProt: P00520
Entrez ID: 11350
|
Does Knockout of Clec2g in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Clec2g
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Clec2g (C-type lectin domain family 2, member g)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of osteoclast differentiation, regulation of immune system process; MF: carbohydrate binding, natural killer cell lectin-like receptor binding; CC: cell surface, endoplasmic reticulum, external side of plasma membrane, extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q9D676
Entrez ID: 70809
|
Does Knockout of Cbln2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Cbln2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cbln2 (cerebellin 2 precursor protein)
Type: protein-coding
Summary: The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalamus, and cerebral cortex. The protein can bind to presynaptic neurexins and induce synaptogenesis in cultured neurons. Null mutant mice are viable, fertile and do not display obvious neuroanatomical defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: maintenance of synapse structure, positive regulation of synapse assembly, spontaneous synaptic transmission, synapse organization, trans-synaptic signaling, modulating synaptic transmission; CC: extracellular region, extracellular space, glutamatergic synapse, synapse, synaptic cleft, trans-synaptic protein complex
Pathways:
UniProt: Q8BGU2
Entrez ID: 12405
|
Does Knockout of Ccnb2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Ccnb2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccnb2 (cyclin B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, G2/MI transition of meiotic cell cycle, T cell homeostasis, cell division, in utero embryonic development, mitotic cell cycle phase transition, regulation of growth, spindle assembly involved in female meiosis I, thymus development; MF: cyclin-dependent protein serine/threonine kinase regulator activity, protein binding; CC: centrosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, membrane, microtubule cytoskeleton, microtubule organizing center, nucleus
Pathways: Activation of NIMA Kinases NEK9, NEK6, NEK7, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Cyclin A/B1/B2 associated events during G2/M transition, FoxO signaling pathway - Mus musculus (mouse), G2/M Checkpoints, G2/M DNA replication checkpoint, G2/M Transition, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Oocyte meiosis - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, The role of GTSE1 in G2/M progression after G2 checkpoint, p53 signaling pathway - Mus musculus (mouse)
UniProt: P30276
Entrez ID: 12442
|
Does Knockout of Myrf in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Myrf
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Myrf (myelin regulatory factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, central nervous system myelin maintenance, central nervous system myelination, oligodendrocyte development, oligodendrocyte differentiation, positive regulation of DNA-templated transcription, positive regulation of myelination, positive regulation of oligodendrocyte differentiation, protein autoprocessing, proteolysis, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to cocaine, response to immobilization stress; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, hydrolase activity, identical protein binding, peptidase activity, protein binding, sequence-specific DNA binding; CC: Golgi apparatus, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm, nucleus
Pathways:
UniProt: Q3UR85
Entrez ID: 225908
|
Does Knockout of Iqce in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Iqce
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Iqce (IQ motif containing E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: limb morphogenesis, positive regulation of transcription by RNA polymerase II, protein localization to motile cilium, regulation of smoothened signaling pathway; CC: cell projection, ciliary membrane, cilium, cytoplasmic side of plasma membrane, membrane, mitochondrion, plasma membrane, plasma membrane protein complex
Pathways: Hedgehog signaling pathway - Mus musculus (mouse)
UniProt: Q6PCQ0
Entrez ID: 74239
|
Does Knockout of Gpam in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Gpam
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gpam (glycerol-3-phosphate acyltransferase, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, acyl-CoA metabolic process, cellular response to insulin stimulus, defense response to virus, diacylglycerol biosynthetic process, fatty acid homeostasis, fatty acid metabolic process, glycerophospholipid metabolic process, lipid metabolic process, negative regulation of activation-induced cell death of T cells, phosphatidic acid biosynthetic process, phosphatidylglycerol biosynthetic process, phospholipid biosynthetic process, phospholipid homeostasis, positive regulation of activated T cell proliferation, positive regulation of multicellular organism growth, positive regulation of triglyceride biosynthetic process, regulation of cytokine production, response to activity, response to glucose, triglyceride biosynthetic process, triglyceride metabolic process; MF: O-acyltransferase activity, acyltransferase activity, glycerol-3-phosphate O-acyltransferase activity, transferase activity; CC: endoplasmic reticulum membrane, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, plasma membrane
Pathways: CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA, Triglyceride biosynthesis, Triglyceride metabolism, phosphatidylglycerol biosynthesis I (plastidic), phosphatidylglycerol biosynthesis II (non-plastidic), phospholipid biosynthesis I, triacylglycerol biosynthesis
UniProt: Q61586
Entrez ID: 14732
|
Does Knockout of Copg1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Copg1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Copg1 (coatomer protein complex, subunit gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of Golgi localization, intra-Golgi vesicle-mediated transport, intracellular protein transport, organelle transport along microtubule, protein secretion, protein transport, vesicle-mediated transport; CC: COPI vesicle coat, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, membrane, membrane coat
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9QZE5
Entrez ID: 54161
|
Does Knockout of Sntg1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Sntg1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sntg1 (syntrophin, gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: actin binding, structural molecule activity; CC: cytoplasm, cytoskeleton, dystrophin-associated glycoprotein complex, nucleus, ruffle membrane, syntrophin complex
Pathways:
UniProt: Q925E1
Entrez ID: 71096
|
Does Knockout of Zcchc17 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Zcchc17
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zcchc17 (zinc finger, CCHC domain containing 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, identical protein binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: cytosolic large ribosomal subunit, nucleolus, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q9ESX4
Entrez ID: 619605
|
Does Knockout of Pla2g6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Pla2g6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pla2g6 (phospholipase A2, group VI)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, cardiolipin acyl-chain remodeling, chemotaxis, lipid metabolic process, memory, negative regulation of synaptic transmission, glutamatergic, phosphatidic acid metabolic process, phosphatidylcholine catabolic process, phosphatidylethanolamine catabolic process, platelet activating factor metabolic process, positive regulation of arachidonate secretion, positive regulation of ceramide biosynthetic process, positive regulation of cytosolic calcium ion concentration, positive regulation of exocytosis, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of intracellular signal transduction, positive regulation of release of cytochrome c from mitochondria, response to endoplasmic reticulum stress, urinary bladder smooth muscle contraction, vasodilation; MF: 1-alkyl-2-acetylglycerophosphocholine esterase activity, ATP-dependent protein binding, calcium-independent phospholipase A2 activity, calmodulin binding, hydrolase activity, identical protein binding, long-chain fatty acyl-CoA hydrolase activity, phosphatidylcholine lysophospholipase activity, phospholipase A2 activity, protein kinase binding, serine hydrolase activity; CC: cell projection, cytoplasm, extracellular space, membrane, microtubule cytoskeleton, mitochondrion, nuclear speck, plasma membrane, pseudopodium
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Arachidonic acid metabolism - Mus musculus (mouse), COPI-independent Golgi-to-ER retrograde traffic, Ether lipid metabolism - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Golgi-to-ER retrograde transport, Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Linoleic acid metabolism - Mus musculus (mouse), Membrane Trafficking, Metabolism, Metabolism of lipids, Phospholipid metabolism, Ras signaling pathway - Mus musculus (mouse), Role of phospholipids in phagocytosis, Vascular smooth muscle contraction - Mus musculus (mouse), Vesicle-mediated transport, alpha-Linolenic acid metabolism - Mus musculus (mouse), phospholipases
UniProt: P97819
Entrez ID: 53357
|
Does Knockout of Snap47 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Snap47
|
cell proliferation
|
Regulatory T cell
|
Gene: Snap47 (synaptosomal-associated protein, 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytic insertion of neurotransmitter receptor to postsynaptic membrane, exocytosis, long-term synaptic potentiation, synaptic vesicle fusion to presynaptic active zone membrane, synaptic vesicle priming, vesicle-mediated transport in synapse; MF: SNAP receptor activity, syntaxin binding; CC: BLOC-1 complex, SNARE complex, asymmetric synapse, cytoplasm, dendrite, endomembrane system, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane, neuronal cell body, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, presynaptic active zone, synapse
Pathways:
UniProt: Q8R570
Entrez ID: 67826
|
Does Knockout of Cdcp2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Cdcp2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cdcp2 (CUB domain containing protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8BQH6
Entrez ID: 242603
|
Does Knockout of Sec23b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Sec23b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sec23b (SEC23 homolog B, COPII coat complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII-coated vesicle budding, COPII-coated vesicle cargo loading, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport, vesicle-mediated transport; MF: GTPase activator activity, metal ion binding, protein binding, zinc ion binding; CC: COPII vesicle coat, ER to Golgi transport vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane, perinuclear region of cytoplasm
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9D662
Entrez ID: 27054
|
Does Knockout of Krt42 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Krt42
|
cell proliferation
|
Regulatory T cell
|
Gene: Krt42 (keratin 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium; MF: structural constituent of skin epidermis, structural molecule activity; CC: cytoplasm, cytoskeleton, intermediate filament, keratin filament
Pathways: Estrogen signaling pathway - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Q6IFX2
Entrez ID: 68239
|
Does Knockout of Bcl2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Bcl2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Bcl2 (B cell leukemia/lymphoma 2)
Type: protein-coding
Summary: This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: B cell apoptotic process, B cell differentiation, B cell homeostasis, B cell lineage commitment, B cell proliferation, B cell receptor signaling pathway, CD8-positive, alpha-beta T cell lineage commitment, DNA damage response, T cell apoptotic process, T cell differentiation, T cell differentiation in thymus, T cell homeostasis, T cell lineage commitment, actin filament organization, animal organ morphogenesis, apoptotic mitochondrial changes, apoptotic process, autophagy, axon regeneration, axonogenesis, behavioral fear response, branching involved in ureteric bud morphogenesis, cell morphogenesis, cell population proliferation, cell-cell adhesion, cellular response to glucose starvation, cellular response to hypoxia, cochlear nucleus development, defense response to virus, developmental growth, developmental pigmentation, digestive tract morphogenesis, ear development, endoplasmic reticulum calcium ion homeostasis, establishment of localization in cell, extrinsic apoptotic signaling pathway in absence of ligand, extrinsic apoptotic signaling pathway via death domain receptors, focal adhesion assembly, gland morphogenesis, glomerulus development, hair follicle morphogenesis, hematopoietic stem cell differentiation, hemopoiesis, homeostasis of number of cells within a tissue, immune system development, intracellular calcium ion homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, intrinsic apoptotic signaling pathway in response to oxidative stress, kidney development, leukocyte homeostasis, lymphocyte apoptotic process, lymphocyte homeostasis, lymphoid progenitor cell differentiation, male gonad development, melanin metabolic process, melanocyte differentiation, mesenchymal cell development, metanephros development, negative regulation of B cell apoptotic process, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell apoptotic process, negative regulation of anoikis, negative regulation of apoptotic process, negative regulation of apoptotic signaling pathway, negative regulation of autophagy, negative regulation of calcium ion transport into cytosol, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell growth, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of cellular pH reduction, negative regulation of dendritic cell apoptotic process, negative regulation of epithelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of lymphocyte apoptotic process, negative regulation of mitotic cell cycle, negative regulation of motor neuron apoptotic process, negative regulation of myeloid cell apoptotic process, negative regulation of neuron apoptotic process, negative regulation of ossification, negative regulation of osteoblast proliferation, negative regulation of retinal cell programmed cell death, neuron apoptotic process, oocyte development, organ growth, ossification, ovarian follicle development, pigment granule organization, pigmentation, positive regulation of B cell proliferation, positive regulation of apoptotic process, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of developmental pigmentation, positive regulation of melanocyte differentiation, positive regulation of multicellular organism growth, positive regulation of neuron maturation, positive regulation of skeletal muscle fiber development, positive regulation of smooth muscle cell migration, post-embryonic development, protein polyubiquitination, reactive oxygen species metabolic process, regulation of apoptotic process, regulation of autophagy, regulation of calcium ion transport, regulation of cell cycle, regulation of cell-matrix adhesion, regulation of developmental pigmentation, regulation of gene expression, regulation of glycoprotein biosynthetic process, regulation of growth, regulation of mitochondrial membrane permeability, regulation of mitochondrial membrane potential, regulation of nitrogen utilization, regulation of programmed cell death, regulation of protein localization, regulation of protein stability, regulation of viral genome replication, release of cytochrome c from mitochondria, renal system process, response to UV-B, response to cytokine, response to ethanol, response to gamma radiation, response to glucocorticoid, response to hydrogen peroxide, response to iron ion, response to ischemia, response to nicotine, response to oxidative stress, response to steroid hormone, response to toxic substance, response to xenobiotic stimulus, spleen development, stem cell development, thymus development, ureteric bud development; MF: BH domain binding, BH3 domain binding, DNA-binding transcription factor binding, channel activity, channel inhibitor activity, identical protein binding, molecular adaptor activity, protease binding, protein binding, protein heterodimerization activity, protein phosphatase 2A binding, protein phosphatase binding, protein-containing complex binding, sequence-specific DNA binding, ubiquitin protein ligase binding; CC: BAD-BCL-2 complex, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial crista, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, myelin sheath, nuclear membrane, nucleus, perinuclear region of cytoplasm, pore complex, protein-containing complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Activation of BAD and translocation to mitochondria , Activation of BH3-only proteins, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis, Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hedgehog signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Inflammasomes, Innate Immune System, Intrinsic Pathway for Apoptosis, JAK-STAT signaling pathway - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, PI3K-Akt signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Programmed Cell Death, Prostate cancer - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), The NLRP1 inflammasome, Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P10417
Entrez ID: 12043
|
Does Knockout of Lrig1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Lrig1
|
cell proliferation
|
Regulatory T cell
|
Gene: Lrig1 (leucine-rich repeats and immunoglobulin-like domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hair cycle process, innervation, otolith morphogenesis, sensory perception of sound; CC: membrane, plasma membrane
Pathways: Negative regulation of MET activity, Signal Transduction, Signaling by EGFR, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: P70193
Entrez ID: 16206
|
Does Knockout of Brinp3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Brinp3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Brinp3 (bone morphogenetic protein/retinoic acid inducible neural specific 3)
Type: protein-coding
Summary: Involved in cellular response to retinoic acid; central nervous system neuron differentiation; and negative regulation of mitotic cell cycle. Acts upstream of or within exploration behavior; nervous system development; and social behavior. Predicted to be located in extracellular region and mitochondrion. Predicted to be active in cytoplasm; dendrite; and neuronal cell body. Is expressed in central nervous system; olfactory epithelium; and submandibular gland primordium. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human BRINP3 (BMP/retinoic acid inducible neural specific 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to retinoic acid, central nervous system neuron differentiation, exploration behavior, multicellular organism growth, negative regulation of cell cycle, negative regulation of mitotic cell cycle, nervous system development, positive regulation of neuron differentiation, regulation of cell cycle, social behavior; CC: cytoplasm, dendrite, extracellular region, mitochondrion, neuronal cell body
Pathways:
UniProt: Q499E0
Entrez ID: 215378
|
Does Knockout of Iapp in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Iapp
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Iapp (islet amyloid polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenylate cyclase-activating G protein-coupled receptor signaling pathway, amylin receptor 1 signaling pathway, amylin receptor 2 signaling pathway, amylin receptor 3 signaling pathway, amylin receptor signaling pathway, amyloid fibril formation, eating behavior, negative regulation of bone resorption, negative regulation of cell population proliferation, negative regulation of osteoclast differentiation, positive regulation of ERK1 and ERK2 cascade, positive regulation of cAMP/PKA signal transduction, positive regulation of calcium-mediated signaling, positive regulation of gene expression, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, protein destabilization, protein homooligomerization, sensory perception of pain; MF: hormone activity, identical protein binding, lipid binding, receptor ligand activity, signaling receptor binding; CC: cytosol, extracellular region, extracellular space, inclusion body, neuronal cell body
Pathways: Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Maturity onset diabetes of the young - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P12968
Entrez ID: 15874
|
Does Knockout of Vmn1r138 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Vmn1r138
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r138 (vomeronasal 1 receptor 138)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: D3YTY2
Entrez ID: 100043029
|
Does Knockout of Iah1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Iah1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Iah1 (isoamyl acetate-hydrolyzing esterase 1 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, gene expression, lipid catabolic process, lipid metabolic process; MF: hydrolase activity, hydrolase activity, acting on ester bonds, identical protein binding, molecular_function
Pathways:
UniProt: Q9DB29
Entrez ID: 67732
|
Does Knockout of Eftud2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Eftud2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Eftud2 (elongation factor Tu GTP binding domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: GTP binding, GTPase activity, U5 snRNA binding, nucleotide binding, protein binding; CC: Cajal body, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, catalytic step 2 spliceosome, cytosol, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: O08810
Entrez ID: 20624
|
Does Knockout of Cd200r3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Cd200r3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cd200r3 (CD200 receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse)
UniProt: Q5UKY4
Entrez ID: 74603
|
Does Knockout of Wdr74 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Wdr74
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Wdr74 (WD repeat domain 74)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA metabolic process, blastocyst formation, rRNA processing, ribosomal large subunit biogenesis; CC: nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q8VCG3
Entrez ID: 107071
|
Does Knockout of Cacng4 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Cacng4
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Cacng4 (calcium channel, voltage-dependent, gamma subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of synaptic transmission, glutamatergic, postsynaptic neurotransmitter receptor diffusion trapping, regulation of AMPA receptor activity, response to cocaine, transmission of nerve impulse; MF: calcium channel activity, calcium channel regulator activity, channel regulator activity, ionotropic glutamate receptor binding, voltage-gated calcium channel activity; CC: AMPA glutamate receptor complex, L-type voltage-gated calcium channel complex, cell body, cell surface, glutamatergic synapse, membrane, monoatomic ion channel complex, plasma membrane, postsynaptic density membrane, somatodendritic compartment, synapse, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Developmental Biology, Dilated cardiomyopathy - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Hypertrophic cardiomyopathy - Mus musculus (mouse), LGI-ADAM interactions, MAPK signaling pathway - Mus musculus (mouse), Muscle contraction, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Oxytocin signaling pathway - Mus musculus (mouse), Phase 0 - rapid depolarisation, Phase 2 - plateau phase, Presynaptic depolarization and calcium channel opening, Trafficking of AMPA receptors, Transmission across Chemical Synapses
UniProt: Q9JJV4
Entrez ID: 54377
|
Does Knockout of Islr2 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Islr2
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Islr2 (immunoglobulin superfamily containing leucine-rich repeat 2)
Type: protein-coding
Summary: Involved in positive regulation of axon extension. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: nervous system development, positive regulation of axon extension; CC: cell surface, membrane, plasma membrane
Pathways:
UniProt: Q5RKR3
Entrez ID: 320563
|
Does Knockout of Scgb2b26 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Scgb2b26
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Scgb2b26 (secretoglobin, family 2B, member 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q8JZX1
Entrez ID: 110187
|
Does Knockout of Prap1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Prap1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Prap1 (proline-rich acidic protein 1)
Type: protein-coding
Summary: Enables triglyceride binding activity. Involved in several processes, including cellular response to X-ray; positive regulation of intestinal lipid absorption; and positive regulation of lipid transport. Located in endoplasmic reticulum and extracellular region. Is expressed in several structures, including female reproductive system; intestine; and lower jaw. Orthologous to human PRAP1 (proline rich acidic protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, cellular response to X-ray, deactivation of mitotic spindle assembly checkpoint, negative regulation of apoptotic process, positive regulation of intestinal lipid absorption, positive regulation of phospholipid transport, positive regulation of triglyceride transport; MF: lipid binding, protein binding, triglyceride binding; CC: endoplasmic reticulum, extracellular region
Pathways: Autophagy - animal - Mus musculus (mouse)
UniProt: Q80XD8
Entrez ID: 22264
|
Does Knockout of Cspg4 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Cspg4
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Cspg4 (chondroitin sulfate proteoglycan 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell differentiation, glial cell migration, intracellular signal transduction, negative regulation of neuron projection development, neuron remodeling, platelet-derived growth factor receptor signaling pathway, positive regulation of MAPK cascade, ruffle assembly, signal transduction, substrate-dependent cell migration, tissue remodeling; MF: collagen binding, coreceptor activity, protein binding, protein kinase binding; CC: apical plasma membrane, cell projection, cell surface, extracellular matrix, lamellipodium membrane, membrane, nucleoplasm, plasma membrane, ruffle
Pathways: CS-GAG biosynthesis, CS/DS degradation, Chondroitin sulfate/dermatan sulfate metabolism, DS-GAG biosynthesis, Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q8VHY0
Entrez ID: 121021
|
Does Knockout of Arid1a in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Arid1a
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Arid1a (AT-rich interaction domain 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac chamber development, cardiac muscle cell differentiation, chromatin organization, chromatin remodeling, embryo implantation, forebrain development, formation of primary germ layer, gastrulation, negative regulation of transcription by RNA polymerase II, nervous system development, neural tube closure, nucleosome disassembly, optic cup formation involved in camera-type eye development, placenta blood vessel development, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, stem cell population maintenance; MF: ATP-dependent chromatin remodeler activity, DNA binding, nuclear receptor binding, nucleosome binding, protein binding; CC: SWI/SNF complex, bBAF complex, brahma complex, chromatin, nBAF complex, npBAF complex, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: A2BH40
Entrez ID: 93760
|
Does Knockout of Chdh in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Chdh
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Chdh (choline dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: choline dehydrogenase activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Choline catabolism, Glycine, serine and threonine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives
UniProt: Q8BJ64
Entrez ID: 218865
|
Does Knockout of Ndrg3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,308
|
Knockout
|
Ndrg3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ndrg3 (N-myc downstream regulated gene 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: decidualization, signal transduction; CC: cytoplasm
Pathways:
UniProt: Q9QYF9
Entrez ID: 29812
|
Does Knockout of Tor3a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Tor3a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tor3a (torsin family 3, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, nucleotide binding, protein binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum lumen, nuclear envelope
Pathways:
UniProt: Q9ER38
Entrez ID: 30935
|
Does Knockout of Mettl17 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,272
|
Knockout
|
Mettl17
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mettl17 (methyltransferase like 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial small ribosomal subunit assembly, ribosomal small subunit biogenesis, translation; MF: 4 iron, 4 sulfur cluster binding, S-adenosyl-L-methionine binding, iron-sulfur cluster binding, metal ion binding, methyltransferase activity, mitochondrial ribosome binding, small molecule binding; CC: intracellular organelle lumen, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways:
UniProt: Q3U2U7
Entrez ID: 52535
|
Does Knockout of Zfp92 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Zfp92
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Zfp92 (zinc finger protein 92)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of glucose metabolic process, regulation of lipid metabolic process, regulation of transcription by RNA polymerase II, transposable element silencing; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q62396
Entrez ID: 22754
|
Does Knockout of Mttp in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Mttp
|
response to virus
|
Microglial Cell Line
|
Gene: Mttp (microsomal triglyceride transfer protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide 1-phosphate transport, cholesterol homeostasis, cholesterol metabolic process, circadian rhythm, establishment of localization in cell, gene expression, glutamine metabolic process, glycolytic process, intermembrane lipid transfer, lipid metabolic process, lipid transport, lipoprotein metabolic process, lipoprotein transport, low-density lipoprotein particle remodeling, phospholipid transport, plasma lipoprotein particle assembly, protein secretion, response to calcium ion, steroid metabolic process, sterol transport, triglyceride metabolic process, triglyceride transport, very-low-density lipoprotein particle clearance; MF: apolipoprotein binding, ceramide 1-phosphate transfer activity, cholesterol transfer activity, lipid binding, lipid transporter activity, phosphatidylcholine transfer activity, phosphatidylethanolamine transfer activity, phospholipid transfer activity, phospholipid transporter activity, protein binding, protein heterodimerization activity, protein-containing complex binding, triglyceride transfer activity; CC: Golgi apparatus, basolateral plasma membrane, brush border membrane, cytosol, endoplasmic reticulum, microvillus membrane, receptor complex, vesicle
Pathways: Chylomicron assembly, Fat digestion and absorption - Mus musculus (mouse), LDL remodeling, Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Transport of small molecules, VLDL assembly
UniProt: O08601
Entrez ID: 17777
|
Does Knockout of Hoxc9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Hoxc9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hoxc9 (homeobox C9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, anterior/posterior pattern specification, embryonic skeletal system development, embryonic skeletal system morphogenesis, proximal/distal pattern formation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal system development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: aggresome, nucleoplasm, nucleus, transcription repressor complex
Pathways:
UniProt: P09633
Entrez ID: 15427
|
Does Knockout of Nckap1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Nckap1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nckap1 (NCK-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, apical protein localization, basal protein localization, cell migration, cell migration involved in gastrulation, cell morphogenesis, cell projection assembly, cortical actin cytoskeleton organization, embryonic body morphogenesis, embryonic foregut morphogenesis, embryonic heart tube development, endoderm development, establishment or maintenance of actin cytoskeleton polarity, in utero embryonic development, lamellipodium assembly, mesodermal cell migration, neural tube closure, neuron projection morphogenesis, notochord development, notochord morphogenesis, paraxial mesoderm development, paraxial mesoderm morphogenesis, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of actin filament polymerization, positive regulation of lamellipodium assembly, protein stabilization, regulation of protein localization, somitogenesis, zygotic determination of anterior/posterior axis, embryo; MF: protein binding, small GTPase binding; CC: SCAR complex, cell projection, cytoplasm, filamentous actin, glutamatergic synapse, lamellipodium, lamellipodium membrane, membrane, plasma membrane, postsynapse, postsynaptic density, ruffle
Pathways: Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: P28660
Entrez ID: 50884
|
Does Knockout of Cwc25 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Cwc25
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cwc25 (CWC25 spliceosome-associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; CC: U2-type catalytic step 1 spliceosome, U2-type spliceosomal complex, nuclear speck, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9DBF7
Entrez ID: 67480
|
Does Knockout of Cpox in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Cpox
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cpox (coproporphyrinogen oxidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment or maintenance of transmembrane electrochemical gradient, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, porphyrin-containing compound biosynthetic process, potassium ion transport, protoporphyrinogen IX biosynthetic process, response to arsenic-containing substance, response to insecticide, response to iron ion, response to lead ion, response to methylmercury, sodium ion transport; MF: P-type sodium:potassium-exchanging transporter activity, coproporphyrinogen oxidase activity, identical protein binding, oxidoreductase activity, protein homodimerization activity, structural constituent of eye lens; CC: cytoplasm, cytosol, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion
Pathways: Heme biosynthesis, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, heme biosynthesis from uroporphyrinogen-III I
UniProt: P36552
Entrez ID: 12892
|
Does Knockout of Smu1 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Smu1
|
phagocytosis
|
macrophage
|
Gene: Smu1 (smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, regulation of alternative mRNA splicing, via spliceosome; CC: U2-type precatalytic spliceosome, cytoplasm, nuclear speck, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q3UKJ7
Entrez ID: 74255
|
Does Knockout of Tesk1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Tesk1
|
phagocytosis
|
macrophage
|
Gene: Tesk1 (testis specific protein kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, establishment of vesicle localization, negative regulation of cilium assembly, nuclear-transcribed mRNA catabolic process, no-go decay, podocyte cell migration, positive regulation of protein localization to nucleus, positive regulation of stress fiber assembly, positive regulation of substrate adhesion-dependent cell spreading, regulation of actin cytoskeleton organization, regulation of protein localization, spermatogenesis; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine kinase inhibitor activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cell projection, centrosome, cytoplasm, cytoplasmic vesicle, cytoskeleton, lamellipodium, nucleus, perinuclear region of cytoplasm
Pathways: Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
UniProt: O70146
Entrez ID: 21754
|
Does Knockout of Oog4 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Oog4
|
phagocytosis
|
macrophage
|
Gene: Oog4 (oogenesin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q4G0C7, Q8BHX9
Entrez ID: 242737
|
Does Knockout of Usp11 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Usp11
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Usp11 (ubiquitin specific peptidase 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, transcription corepressor binding; CC: chromosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q99K46
Entrez ID: 236733
|
Does Knockout of R3hdm4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
R3hdm4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: R3hdm4 (R3H domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, nucleic acid binding; CC: cellular_component, nucleus
Pathways:
UniProt: Q4VBF2
Entrez ID: 109284
|
Does Knockout of Bora in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Bora
|
response to bacteria
|
macrophage
|
Gene: Bora (bora, aurora kinase A activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, regulation of mitotic nuclear division, regulation of mitotic spindle organization, regulation of protein localization; MF: protein kinase binding; CC: cytoplasm, meiotic spindle, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q8BS90
Entrez ID: 77744
|
Does Knockout of Casz1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Casz1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Casz1 (castor zinc finger 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of amacrine cell differentiation, negative regulation of glial cell differentiation, negative regulation of neuron differentiation, negative regulation of retinal cone cell fate commitment, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, radial glial cell differentiation, regulation of DNA-templated transcription, regulation of neuron differentiation, retinal bipolar neuron differentiation, retinal rod cell fate commitment; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: chromatin, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9CWL2
Entrez ID: 69743
|
Does Knockout of Ccdc171 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Ccdc171
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Ccdc171 (coiled-coil domain containing 171)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q1U1
Entrez ID: 320226
|
Does Knockout of Svep1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Svep1
|
phagocytosis
|
macrophage
|
Gene: Svep1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1)
Type: protein-coding
Summary: Enables chromatin binding activity and integrin binding activity involved in cell-matrix adhesion. Involved in positive regulation of platelet activation. Acts upstream of or within several processes, including Tie signaling pathway; lymph circulation; and lymph vessel morphogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver sinusoid; and respiratory system. Orthologous to human SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Tie signaling pathway, cell adhesion, cell migration, cell-matrix adhesion, circulatory system process, epidermis development, epithelial cell-cell adhesion, gene expression, lymph circulation, lymph vessel development, lymph vessel morphogenesis, negative regulation of vasoconstriction, positive regulation of platelet activation, tight junction organization; MF: calcium ion binding, chromatin binding, integrin binding, integrin binding involved in cell-matrix adhesion, protein binding; CC: cytoplasm, extracellular matrix, extracellular region, extracellular space, membrane, nucleus
Pathways:
UniProt: A2AVA0
Entrez ID: 64817
|
Does Knockout of Ppm1l in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Ppm1l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ppm1l (protein phosphatase 1 (formerly 2C)-like)
Type: protein-coding
Summary: Enables protein serine/threonine phosphatase activity. Acts upstream of or within MAPK cascade and cell surface receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including gut; limb segment; metanephros; nervous system; and sensory organ. Orthologous to human PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: MAPK cascade, cell surface receptor protein serine/threonine kinase signaling pathway, signal transduction; MF: cation binding, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity
Pathways:
UniProt: Q8BHN0
Entrez ID: 242083
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Does Knockout of Rhot2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,683
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Knockout
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Rhot2
|
protein/peptide distribution
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myoblast cell line
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Gene: Rhot2 (ras homolog family member T2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular homeostasis, establishment of mitochondrion localization, microtubule-mediated, mitochondrial outer membrane permeabilization, mitochondrion organization, mitochondrion transport along microtubule; MF: ATP hydrolysis activity, GDP binding, GTP binding, GTPase activity, calcium ion binding, hydrolase activity, magnesium ion binding, metal ion binding, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion
Pathways: Miro GTPase Cycle, Mitophagy - animal - Mus musculus (mouse), RHOT2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8JZN7
Entrez ID: 214952
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