prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Cdk5rap1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Cdk5rap1 | cell proliferation | Colonic Cancer Cell Line | Gene: Cdk5rap1 (CDK5 regulatory subunit associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, mitochondrial tRNA modification, negative regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of mitoch... |
Does Knockout of Uba3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Uba3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Uba3 (ubiquitin-like modifier activating enzyme 3)
Type: protein-coding
Summary: The protein encoded by this gene is the catalytic subunit of the enzyme that activates NEDD8, a ubiquitin-like molecule that binds to its target proteins through an enzymatic reaction analagous to ubiquitylation. Embr... |
Does Knockout of Tmem216 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Tmem216 | cell proliferation | Colonic Cancer Cell Line | Gene: Tmem216 (transmembrane protein 216)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which is involved in regulation of signaling and trafficking of associated proteins. In humans, mutations in this gene are associated with ciliopathies including Joubert, Meckel and related ... |
Does Knockout of Vgll1 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,679 | Knockout | Vgll1 | protein/peptide distribution | myoblast cell line | Gene: Vgll1 (vestigial like family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q99NC0
Entrez I... |
Does Knockout of Siva1 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Siva1 | cell cycle progression | breast epithelium | Gene: Siva1 (SIVA1, apoptosis-inducing factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell apoptotic process, T cell receptor signaling pathway, activation-induced cell death of T cells, apoptotic process, extrinsic apoptotic signaling pathway, intrinsic apopto... |
Does Knockout of Tbr1 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Tbr1 | protein/peptide accumulation | Microglial Cell Line | Gene: Tbr1 (T-box brain transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amygdala development, cell fate specification, cerebral cortex development, chromatin remodeling, commitment of neuronal cell to specific neuron type in forebrain, conditioned ... |
Does Knockout of Ssxb2 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Ssxb2 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Ssxb2 (SSX member B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C5Z3, Q80ZT4
Entrez ID: 387132 |
Does Knockout of Paqr9 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Paqr9 | cell viability | Immortal mouse chromaffin cells | Gene: Paqr9 (progestin and adipoQ receptor family member IX)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: lipid binding, signaling receptor activity, steroid binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q6TCG2
Entrez ID: 75552 |
Does Knockout of Sugt1 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Sugt1 | protein/peptide accumulation | Microglial Cell Line | Gene: Sugt1 (SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: kinetochore assembly, regulation of protein stability, skeletal muscle satellite cell proliferation, spindle organization; MF: lncRNA binding, protein-foldi... |
Does Knockout of Maged1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Maged1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Maged1 (MAGE family member D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian regulation of gene expression, negative regulation of DNA-templated transcription, negative regulation of epithelial cell proliferation, negative regulation of protein localizat... |
Does Knockout of Snw1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Snw1 | cell proliferation | Melanoma Cell Line | Gene: Snw1 (SNW domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cellular response to retinoic acid, host-mediated activation of viral transcription, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, m... |
Does Knockout of Arid1b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Arid1b | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Arid1b (AT-rich interaction domain 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, dendritic cell dendrite assembly, dendritic spine development, nervous system development, neuron-neuron synaptic transmission, posit... |
Does Knockout of Mmp20 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Mmp20 | cell proliferation | Embryonic Stem Cell Line | Gene: Mmp20 (matrix metallopeptidase 20 (enamelysin))
Type: protein-coding
Summary: This gene encodes a member of the matrix metalloproteinase family of zinc-dependent endopeptidases capable of degrading extracellular matrix proteins. This gene is expressed specifically in the ameloblasts and odontoblas... |
Does Knockout of Scmh1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Scmh1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Scmh1 (Scm polycomb group homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, chromatin remodeling, heterochromatin formation, negative regulation of DNA-templated transcription, regulation of DNA-templated transcript... |
Does Knockout of Ints9 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 1,266 | Knockout | Ints9 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Ints9 (integrator complex subunit 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of transmembrane rece... |
Does Knockout of Zfp800 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Zfp800 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Zfp800 (zinc finger protein 800)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acinar cell differentiation, endocrine pancreas development; MF: DNA binding, metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q0VEE6
... |
Does Knockout of Rbm46 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Rbm46 | cell proliferation | Mouse kidney carcinoma cell | Gene: Rbm46 (RNA binding motif protein 46)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell cycle switching, mitotic to meiotic cell cycle, cell differentiation, female meiotic nuclear division, mRNA stabilization, male meiotic nuclear division, meiotic cell cycle, oo... |
Does Knockout of Fam76a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Fam76a | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Fam76a (family with sequence similarity 76, member A)
Type: protein-coding
Summary: Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Is expressed in embryo. Orthologous to human FAM76A (family with sequence similarity 76 member A). [provided by Alliance of Genome Re... |
Does Knockout of Gria3 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,679 | Knockout | Gria3 | protein/peptide distribution | myoblast cell line | Gene: Gria3 (glutamate receptor, ionotropic, AMPA3 (alpha 3))
Type: protein-coding
Summary: This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutam... |
Does Knockout of Alg1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Alg1 | protein/peptide distribution | myoblast cell line | Gene: Alg1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase)
Type: protein-coding
Summary: Predicted to enable chitobiosyldiphosphodolichol beta-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a ... |
Does Knockout of Zc3h12d in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Zc3h12d | protein/peptide accumulation | Embryonic Cell Line | Gene: Zc3h12d (zinc finger CCCH type containing 12D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, mRNA catabolic process, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell proliferation, ne... |
Does Knockout of Nin in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Nin | cell cycle progression | breast epithelium | Gene: Nin (ninein)
Type: protein-coding
Summary: Enables microtubule minus-end binding activity. Acts upstream of or within several processes, including axonogenesis; microtubule cytoskeleton organization; and positive regulation of axonogenesis. Located in several cellular components, including axonal ... |
Does Knockout of H2-M11 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | H2-M11 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: H2-M11 (histocompatibility 2, M region locus 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous pept... |
Does Knockout of Icam4 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Icam4 | protein/peptide accumulation | Regulatory T cell | Gene: Icam4 (intercellular adhesion molecule 4, Landsteiner-Wiener blood group)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion; MF: integrin binding; CC: cytoplasm, extracellular region, extracellular space, membrane, plasma membrane
... |
Does Knockout of Khsrp in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Khsrp | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Khsrp (KH-type splicing regulatory protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, RNA splicing, cellular response to cytokine stimulus, mRNA catabolic process, mRNA processing, mRNA transport, miRNA metabolic process, ... |
Does Knockout of Cryba4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Cryba4 | protein/peptide distribution | myoblast cell line | Gene: Cryba4 (crystallin, beta A4)
Type: protein-coding
Summary: This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. Certain mutations in the human ortholog of this gene are associated with cataract and bilater... |
Does Knockout of Ppox in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 578 | Knockout | Ppox | cell proliferation | Embryonic Stem Cell Line | Gene: Ppox (protoporphyrinogen oxidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, porphyrin-containing compound biosynthetic process, protoporphyrinogen IX biosynthetic process, pro... |
Does Knockout of Fgd6 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Fgd6 | protein/peptide distribution | myoblast cell line | Gene: Fgd6 (FYVE, RhoGEF and PH domain containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, metal ion binding, molecular_function, zinc ion binding; CC: cytoplasm, cytoskeleton
Pathways:
UniProt: Q69Z... |
Does Knockout of Sptlc1 in bone marrow cell line causally result in regulation of signal transduction phenotype? | 1 | 1,785 | Knockout | Sptlc1 | regulation of signal transduction phenotype | bone marrow cell line | Gene: Sptlc1 (serine palmitoyltransferase, long chain base subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, regulation of fat cell apoptotic process, sphinganine biosynthet... |
Does Knockout of Rmnd5a in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Rmnd5a | protein/peptide accumulation | Regulatory T cell | Gene: Rmnd5a (required for meiotic nuclear division 5 homolog A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein l... |
Does Knockout of Prr30 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Prr30 | cell cycle progression | breast epithelium | Gene: Prr30 (proline rich 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D9B7
Entrez ID: 76627 |
Does Knockout of Sf3b3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 161 | Knockout | Sf3b3 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Sf3b3 (splicing factor 3b, subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, negative regulation of protein catabolic process, positive regulation of DNA-templated transcription, regulation of D... |
Does Knockout of Cpb2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Cpb2 | cell proliferation | Melanoma Cell Line | Gene: Cpb2 (carboxypeptidase B2)
Type: protein-coding
Summary: This gene encodes carboxypeptidase B, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme, an... |
Does Knockout of Mir7064 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Mir7064 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Mir7064 (microRNA 7064)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of Lrit3 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Lrit3 | response to bacteria | renal medulla cell line | Gene: Lrit3 (leucine-rich repeat, immunoglobulin-like and transmembrane domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gene expression, intracellular protein localization, regulation of fibroblast growth factor receptor signaling pathway, response to light sti... |
Does Knockout of Mcm9 in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,539 | Knockout | Mcm9 | response to chemicals | Lymphoma Cell Line | Gene: Mcm9 (minichromosome maintenance 9 homologous recombination repair factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, double-strand break repair via homologous recombination, female gamete generation, gamete gen... |
Does Knockout of Kcns2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Kcns2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Kcns2 (K+ voltage-gated channel, subfamily S, 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomeri... |
Does Knockout of Cabp5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Cabp5 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Cabp5 (calcium binding protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium channel regulator activity, calcium ion binding, metal ion binding; CC: cytoplasm, cytosol
Pathways:
UniProt: Q9JLK3
Entrez ID: 29865 |
Does Knockout of Pcyox1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Pcyox1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Pcyox1 (prenylcysteine oxidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, prenylated protein catabolic process, prenylcysteine catabolic process; MF: FAD binding, farnesylcysteine lyase activity, oxidoreductase activity, oxi... |
Does Knockout of Nav3 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Nav3 | cell proliferation | Melanoma Cell Line | Gene: Nav3 (neuron navigator 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell migration, negative regulation of interleukin-2 production, negative regulation of microtubule depolymerization, nervous system development, neurogenesis, positive ... |
Does Knockout of Cldn5 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Cldn5 | protein/peptide accumulation | Microglial Cell Line | Gene: Cldn5 (claudin 5)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the parace... |
Does Knockout of Fgr in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Fgr | response to bacteria | macrophage | Gene: Fgr (FGR proto-oncogene, Src family tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, cell differentiation, cell surface receptor protein tyrosine kinase signaling pathway, defense response to Gram-positive bacterium, immune syste... |
Does Knockout of Clasp1 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Clasp1 | response to virus | Neuroblastoma Cell Line | Gene: Clasp1 (CLIP associating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, astral microtubule organization, basement membrane organization, cell division, cell migration, establishment of cell polarity, establishment of mitotic spindle l... |
Does Knockout of Mir8098 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Mir8098 | response to virus | Embryonic Fibroblast Cell Line | Gene: Mir8098 (microRNA 8098)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of Vmn1r215 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Vmn1r215 | cell proliferation | Melanoma Cell Line | Gene: Vmn1r215 (vomeronasal 1 receptor 215)
Type: protein-coding
Summary: Predicted to enable pheromone binding activity and pheromone receptor activity. Predicted to act upstream of or within response to pheromone. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, A... |
Does Knockout of Krtap8-1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Krtap8-1 | cell proliferation | Colonic Cancer Cell Line | Gene: Krtap8-1 (keratin associated protein 8-1)
Type: protein-coding
Summary: Predicted to be located in cytosol and intermediate filament. Orthologous to human KRTAP8-1 (keratin associated protein 8-1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component,... |
Does Knockout of Acap1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Acap1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Acap1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lipid catabolic process, lipid metabolic process, signal transduction; MF: GTPase activator activity, metal ion binding, molecular_fu... |
Does Knockout of Ptprc in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,528 | Knockout | Ptprc | response to chemicals | Lymphoma Cell Line | Gene: Ptprc (protein tyrosine phosphatase receptor type C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, B cell proliferation, B cell receptor signaling pathway, T cell differentiation, T cell proliferation, T cell receptor signaling pathway, bon... |
Does Knockout of Fam234a in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Fam234a | phagocytosis | macrophage | Gene: Fam234a (family with sequence similarity 234, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cell surface, membrane
Pathways:
UniProt: Q8C0Z1
Entrez ID: 106581 |
Does Knockout of Abl1 in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Abl1 | cell proliferation | Regulatory T cell | Gene: Abl1 (c-abl oncogene 1, non-receptor tyrosine kinase)
Type: protein-coding
Summary: Enables several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; positive r... |
Does Knockout of Clec2g in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Clec2g | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Clec2g (C-type lectin domain family 2, member g)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of osteoclast differentiation, regulation of immune system process; MF: carbohydrate binding, natural killer cell lectin-like receptor binding; CC: c... |
Does Knockout of Cbln2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Cbln2 | cell proliferation | Melanoma Cell Line | Gene: Cbln2 (cerebellin 2 precursor protein)
Type: protein-coding
Summary: The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalam... |
Does Knockout of Ccnb2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Ccnb2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Ccnb2 (cyclin B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, G2/MI transition of meiotic cell cycle, T cell homeostasis, cell division, in utero embryonic development, mitotic cell cycle phase transition, regulation of gro... |
Does Knockout of Myrf in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Myrf | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Myrf (myelin regulatory factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, central nervous system myelin maintenance, central nervous system myelination, oligodendrocyte development, oligodendrocyte differentiation, positive regulation of ... |
Does Knockout of Iqce in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Iqce | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Iqce (IQ motif containing E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: limb morphogenesis, positive regulation of transcription by RNA polymerase II, protein localization to motile cilium, regulation of smoothened signaling pathway; CC: cell projection, ciliar... |
Does Knockout of Gpam in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,684 | Knockout | Gpam | protein/peptide distribution | myoblast cell line | Gene: Gpam (glycerol-3-phosphate acyltransferase, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, acyl-CoA metabolic process, cellular response to insulin stimulus, defense response to virus, diacylglycerol biosynthe... |
Does Knockout of Copg1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Copg1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Copg1 (coatomer protein complex, subunit gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of Golgi localization, intra-Golgi vesicle-mediated transport, intracellular protein transport,... |
Does Knockout of Sntg1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Sntg1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Sntg1 (syntrophin, gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: actin binding, structural molecule activity; CC: cytoplasm, cytoskeleton, dystrophin-associated glycoprotein complex, nucleus, ruffle membrane, syntrophin complex
Pathways:
... |
Does Knockout of Zcchc17 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Zcchc17 | protein/peptide distribution | myoblast cell line | Gene: Zcchc17 (zinc finger, CCHC domain containing 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, identical protein binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: cytosolic large ribosomal subunit, nucleolus, nucleus, ribonucleop... |
Does Knockout of Pla2g6 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Pla2g6 | cell proliferation | Colonic Cancer Cell Line | Gene: Pla2g6 (phospholipase A2, group VI)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, cardiolipin acyl-chain remodeling, chemotaxis, lipid metabolic process, memory, negative regulation of synaptic transmission, glutamatergic, phosphati... |
Does Knockout of Snap47 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Snap47 | cell proliferation | Regulatory T cell | Gene: Snap47 (synaptosomal-associated protein, 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytic insertion of neurotransmitter receptor to postsynaptic membrane, exocytosis, long-term synaptic potentiation, synaptic vesicle fusion to presynaptic active zone mem... |
Does Knockout of Cdcp2 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Cdcp2 | cell proliferation | Embryonic Stem Cell Line | Gene: Cdcp2 (CUB domain containing protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8BQH6
Entrez ID: 242603 |
Does Knockout of Sec23b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 84 | Knockout | Sec23b | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Sec23b (SEC23 homolog B, COPII coat complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII-coated vesicle budding, COPII-coated vesicle cargo loading, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, prote... |
Does Knockout of Krt42 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Krt42 | cell proliferation | Regulatory T cell | Gene: Krt42 (keratin 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium; MF: structural constituent of skin epidermis, structural molecule activity; CC: cytoplasm, cytoske... |
Does Knockout of Bcl2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Bcl2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Bcl2 (B cell leukemia/lymphoma 2)
Type: protein-coding
Summary: This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhib... |
Does Knockout of Lrig1 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Lrig1 | cell proliferation | Regulatory T cell | Gene: Lrig1 (leucine-rich repeats and immunoglobulin-like domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hair cycle process, innervation, otolith morphogenesis, sensory perception of sound; CC: membrane, plasma membrane
Pathways: Negative regulation o... |
Does Knockout of Brinp3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Brinp3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Brinp3 (bone morphogenetic protein/retinoic acid inducible neural specific 3)
Type: protein-coding
Summary: Involved in cellular response to retinoic acid; central nervous system neuron differentiation; and negative regulation of mitotic cell cycle. Acts upstream of or within exploration behavior;... |
Does Knockout of Iapp in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Iapp | cell proliferation | Embryonic Stem Cell Line | Gene: Iapp (islet amyloid polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenylate cyclase-activating G protein-coupled receptor signaling pathway, amylin receptor 1 signaling pathway, amylin receptor 2 signaling pathway, amylin receptor 3 signaling pathway,... |
Does Knockout of Vmn1r138 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Vmn1r138 | protein/peptide distribution | myoblast cell line | Gene: Vmn1r138 (vomeronasal 1 receptor 138)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled recepto... |
Does Knockout of Iah1 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Iah1 | protein/peptide accumulation | Regulatory T cell | Gene: Iah1 (isoamyl acetate-hydrolyzing esterase 1 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, gene expression, lipid catabolic process, lipid metabolic process; MF: hydrolase activity, hydrolase activity, acting on ester bonds, identical ... |
Does Knockout of Eftud2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Eftud2 | cell proliferation | Colonic Cancer Cell Line | Gene: Eftud2 (elongation factor Tu GTP binding domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: GTP binding, GTPase activity, U5 snRNA binding, nucleotide binding, protein binding; CC: ... |
Does Knockout of Cd200r3 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Cd200r3 | cell proliferation | Melanoma Cell Line | Gene: Cd200r3 (CD200 receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Kaposi sarcoma-associated herpesvirus infection ... |
Does Knockout of Wdr74 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Wdr74 | protein/peptide distribution | myoblast cell line | Gene: Wdr74 (WD repeat domain 74)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA metabolic process, blastocyst formation, rRNA processing, ribosomal large subunit biogenesis; CC: nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus, preribosome, large sub... |
Does Knockout of Cacng4 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Cacng4 | protein/peptide accumulation | Mouse cell | Gene: Cacng4 (calcium channel, voltage-dependent, gamma subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of synaptic... |
Does Knockout of Islr2 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Islr2 | protein/peptide accumulation | Microglial Cell Line | Gene: Islr2 (immunoglobulin superfamily containing leucine-rich repeat 2)
Type: protein-coding
Summary: Involved in positive regulation of axon extension. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary syste... |
Does Knockout of Scgb2b26 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Scgb2b26 | protein/peptide distribution | myoblast cell line | Gene: Scgb2b26 (secretoglobin, family 2B, member 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q8JZX1
Entrez ID: 110187 |
Does Knockout of Prap1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Prap1 | cell proliferation | Colonic Cancer Cell Line | Gene: Prap1 (proline-rich acidic protein 1)
Type: protein-coding
Summary: Enables triglyceride binding activity. Involved in several processes, including cellular response to X-ray; positive regulation of intestinal lipid absorption; and positive regulation of lipid transport. Located in endoplasmic ret... |
Does Knockout of Cspg4 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Cspg4 | response to chemicals | pro-B-lymphocyte | Gene: Cspg4 (chondroitin sulfate proteoglycan 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell differentiation, glial cell migration, intracellular signal transduction, negative regulation of neuron projection development, neuron remodeling, platelet-... |
Does Knockout of Arid1a in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Arid1a | protein/peptide accumulation | Embryonic Cell Line | Gene: Arid1a (AT-rich interaction domain 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac chamber development, cardiac muscle cell differentiation, chromatin organization, chromatin remodeling, embryo implantation, forebrain development, formation of primary ge... |
Does Knockout of Chdh in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Chdh | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Chdh (choline dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: choline dehydrogenase activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors; CC: membrane, mitochondrial inner mem... |
Does Knockout of Ndrg3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 2,308 | Knockout | Ndrg3 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Ndrg3 (N-myc downstream regulated gene 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: decidualization, signal transduction; CC: cytoplasm
Pathways:
UniProt: Q9QYF9
Entrez ID: 29812 |
Does Knockout of Tor3a in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Tor3a | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Tor3a (torsin family 3, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, nucleotide binding, protein binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum lumen, nuclear envelope
Pathways:
... |
Does Knockout of Mettl17 in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,272 | Knockout | Mettl17 | cell proliferation | Mouse kidney carcinoma cell | Gene: Mettl17 (methyltransferase like 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial small ribosomal subunit assembly, ribosomal small subunit biogenesis, translation; MF: 4 iron, 4 sulfur cluster binding, S-adenosyl-L-methionine binding, iron-sulfur cl... |
Does Knockout of Zfp92 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Zfp92 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Zfp92 (zinc finger protein 92)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of glucose metabolic process, regulation of lipid metabolic process, regul... |
Does Knockout of Mttp in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Mttp | response to virus | Microglial Cell Line | Gene: Mttp (microsomal triglyceride transfer protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide 1-phosphate transport, cholesterol homeostasis, cholesterol metabolic process, circadian rhythm, establishment of localization in cell, gene expression, glutamin... |
Does Knockout of Hoxc9 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Hoxc9 | cell proliferation | Embryonic Stem Cell Line | Gene: Hoxc9 (homeobox C9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, anterior/posterior pattern specification, embryonic skeletal system development, embryonic skeletal system morphogenesis, proximal/distal pattern formation, regulation o... |
Does Knockout of Nckap1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Nckap1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Nckap1 (NCK-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, apical protein localization, basal protein localization, cell migration, cell migration involved in gastrulation, cell morphogenesis, cell projection a... |
Does Knockout of Cwc25 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Cwc25 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Cwc25 (CWC25 spliceosome-associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; CC: U2-type catalytic step 1 spliceosome, U2-type spliceosomal complex, nuclear speck, nucleus, spliceosomal c... |
Does Knockout of Cpox in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,175 | Knockout | Cpox | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Cpox (coproporphyrinogen oxidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment or maintenance of transmembrane electrochemical gradient, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, porphyrin-containing compou... |
Does Knockout of Smu1 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Smu1 | phagocytosis | macrophage | Gene: Smu1 (smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, regulation of alternative mRNA splicing, via spliceosome; CC: U2-type precatalytic spliceo... |
Does Knockout of Tesk1 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Tesk1 | phagocytosis | macrophage | Gene: Tesk1 (testis specific protein kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, establishment of vesicle localization, negative regulation of cilium assembly, nuclear-transcribed mRNA catabolic process, no-go decay, podocyte... |
Does Knockout of Oog4 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Oog4 | phagocytosis | macrophage | Gene: Oog4 (oogenesin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population p... |
Does Knockout of Usp11 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Usp11 | protein/peptide distribution | myoblast cell line | Gene: Usp11 (ubiquitin specific peptidase 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, pept... |
Does Knockout of R3hdm4 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | R3hdm4 | cell proliferation | Mouse kidney carcinoma cell | Gene: R3hdm4 (R3H domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, nucleic acid binding; CC: cellular_component, nucleus
Pathways:
UniProt: Q4VBF2
Entrez ID: 109284 |
Does Knockout of Bora in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Bora | response to bacteria | macrophage | Gene: Bora (bora, aurora kinase A activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, regulation of mitotic nuclear division, regulation of mitotic spindle organization, regulation of protein localization; MF: protein kinase binding; CC: cytoplasm, m... |
Does Knockout of Casz1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Casz1 | protein/peptide distribution | myoblast cell line | Gene: Casz1 (castor zinc finger 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of amacrine cell differentiation, negative regulation of glial cell differentiation, negative regulation of neuron differentiation, negative regulation of retinal cone c... |
Does Knockout of Ccdc171 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Ccdc171 | protein/peptide accumulation | Microglial Cell Line | Gene: Ccdc171 (coiled-coil domain containing 171)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q1U1
Entrez ID: 320226 |
Does Knockout of Svep1 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Svep1 | phagocytosis | macrophage | Gene: Svep1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1)
Type: protein-coding
Summary: Enables chromatin binding activity and integrin binding activity involved in cell-matrix adhesion. Involved in positive regulation of platelet activation. Acts upstream of or within sev... |
Does Knockout of Ppm1l in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Ppm1l | protein/peptide distribution | myoblast cell line | Gene: Ppm1l (protein phosphatase 1 (formerly 2C)-like)
Type: protein-coding
Summary: Enables protein serine/threonine phosphatase activity. Acts upstream of or within MAPK cascade and cell surface receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Is express... |
Does Knockout of Rhot2 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,683 | Knockout | Rhot2 | protein/peptide distribution | myoblast cell line | Gene: Rhot2 (ras homolog family member T2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular homeostasis, establishment of mitochondrion localization, microtubule-mediated, mitochondrial outer membrane permeabilization, mitochondrion organization, mitochondrion tra... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.