prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Apeh in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Apeh
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Apeh (acylpeptide hydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid-beta metabolic process, proteolysis; MF: hydrolase activity, identical protein binding, omega peptidase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, cytosol, nuclear membrane
Pathways: Eukaryotic Translation Termination, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Translation
UniProt: Q8R146
Entrez ID: 235606
|
Does Knockout of Tspan11 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Tspan11
|
cell cycle progression
|
breast epithelium
|
Gene: Tspan11 (tetraspanin 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q9D1D1
Entrez ID: 68498
|
Does Knockout of Nt5c1a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Nt5c1a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nt5c1a (5'-nucleotidase, cytosolic IA)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMP catabolic process, IMP catabolic process, adenosine metabolic process, allantoin metabolic process, amide catabolic process, dAMP catabolic process, dGMP catabolic process, nucleotide metabolic process, purine nucleoside monophosphate catabolic process; MF: 5'-deoxynucleotidase activity, 5'-nucleotidase activity, hydrolase activity, magnesium ion binding, nucleotide binding; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of nucleotides, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nucleotide catabolism, Purine catabolism, Purine metabolism - Mus musculus (mouse), Pyrimidine catabolism, Pyrimidine metabolism - Mus musculus (mouse)
UniProt: A3KFX0
Entrez ID: 230718
|
Does Knockout of Ltbp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Ltbp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ltbp1 (latent transforming growth factor beta binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, coronary vasculature development, establishment of protein localization to extracellular region, positive regulation of collagen biosynthetic process, sequestering of TGFbeta in extracellular matrix, transforming growth factor beta receptor signaling pathway, ventricular septum development; MF: calcium ion binding, extracellular matrix structural constituent, growth factor binding, microfibril binding, molecular adaptor activity, receptor ligand inhibitor activity, transforming growth factor beta binding; CC: dendrite, extracellular matrix, extracellular region, large latent transforming growth factor-beta complex, microfibril, neuronal cell body, perinuclear region of cytoplasm, protein-containing complex
Pathways: Elastic fibre formation, Extracellular matrix organization, Metabolism of proteins, Molecules associated with elastic fibres, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: Q8CG19
Entrez ID: 268977
|
Does Knockout of Inf2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Inf2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Inf2 (inverted formin, FH2 and WH2 domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin nucleation, gene expression, regulation of cellular component size, regulation of mitochondrial fission; MF: actin binding, protein binding, small GTPase binding; CC: cytoplasm, perinuclear region of cytoplasm
Pathways:
UniProt: Q0GNC1
Entrez ID: 70435
|
Does Knockout of Tcte2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Tcte2
|
phagocytosis
|
macrophage
|
Gene: Tcte2 (t-complex-associated testis expressed 2)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 21646
|
Does Knockout of Hacd1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Hacd1
|
cell cycle progression
|
breast epithelium
|
Gene: Hacd1 (3-hydroxyacyl-CoA dehydratase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cementum mineralization, fatty acid biosynthetic process, fatty acid elongation, fatty acid metabolic process, lipid metabolic process, myotube differentiation, positive regulation of cell-substrate adhesion, protein-containing complex assembly, regulation of G1/S transition of mitotic cell cycle, regulation of G2/M transition of mitotic cell cycle, sphingolipid biosynthetic process, very long-chain fatty acid biosynthetic process; MF: 3-hydroxyacyl-CoA dehydratase activity, enzyme binding, hydroxyapatite binding, lyase activity, very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs
UniProt: Q9QY80
Entrez ID: 30963
|
Does Knockout of Zfp398 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Zfp398
|
response to virus
|
Microglial Cell Line
|
Gene: Zfp398 (zinc finger protein 398)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8BVH0, Q8BV16, E9Q569, Q8BL72
Entrez ID: 272347
|
Does Knockout of Neurod4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Neurod4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Neurod4 (neurogenic differentiation 4)
Type: protein-coding
Summary: This gene belongs to the neurogenic differentiation factor family and encodes a basic helix-loop-helix (bHLH) transcription factor which is expressed in the developing nervous system with high levels of expression in the brain, retina and cranial ganglions. Expression gradually becomes restricted to the neural retina. It is a key gene in the Ngn2-regulated neuronal differentiation pathway, coordinating the onset of cortical gene transcription. This gene also regulates amacrine cell fate determination in the retina. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: Notch signaling pathway, amacrine cell differentiation, axon development, camera-type eye development, cell differentiation, cell fate commitment, central nervous system development, motor neuron migration, nervous system development, neuroblast proliferation, neuron development, oligodendrocyte differentiation, positive regulation of cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, retina development in camera-type eye; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, protein dimerization activity; CC: nucleus
Pathways:
UniProt: O09105
Entrez ID: 11923
|
Does Knockout of Golga4 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Golga4
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Golga4 (golgin A4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi vesicle transport, positive regulation of axon extension; MF: GTPase binding, small GTPase binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, membrane, nucleoplasm
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q91VW5
Entrez ID: 54214
|
Does Knockout of Pcbp3 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Pcbp3
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Pcbp3 (poly(rC) binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: C-rich single-stranded DNA binding, DNA binding, RNA binding, mRNA binding, nucleic acid binding, single-stranded DNA binding; CC: cytoplasm, nucleus, ribonucleoprotein complex
Pathways:
UniProt: P57722
Entrez ID: 59093
|
Does Knockout of Spice1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Spice1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Spice1 (spindle and centriole associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, metaphase chromosome alignment, mitotic spindle assembly, regulation of centriole replication; CC: centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, plasma membrane, spindle
Pathways:
UniProt: Q8C804
Entrez ID: 212514
|
Does Knockout of Smco2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Smco2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Smco2 (single-pass membrane protein with coiled-coil domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q9DA21
Entrez ID: 69371
|
Does Knockout of Ltc4s in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Ltc4s
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ltc4s (leukotriene C4 synthase)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme that catalyzes the synthesis of leukotriene C4 by combining leukotriene A4 with reduced glutathione. The encoded protein is found in the outer nuclear membrane and in the peripheral endoplasmic reticulum. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as bronchial asthma in humans. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cellular oxidant detoxification, leukotriene biosynthetic process, leukotriene metabolic process, lipid metabolic process, long-chain fatty acid biosynthetic process; MF: enzyme activator activity, glutathione binding, glutathione peroxidase activity, glutathione transferase activity, identical protein binding, leukotriene-C4 synthase activity, lipid binding, lyase activity, protein-containing complex binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear envelope, nuclear membrane, nuclear outer membrane, nucleus
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biosynthesis of DHA-derived SPMs, Biosynthesis of DHA-derived sulfido conjugates, Biosynthesis of Lipoxins (LX), Biosynthesis of maresin conjugates in tissue regeneration (MCTR), Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR), Biosynthesis of specialized proresolving mediators (SPMs), Fatty acid metabolism, Metabolism, Metabolism of lipids, Synthesis of 5-eicosatetraenoic acids, Synthesis of Leukotrienes (LT) and Eoxins (EX)
UniProt: Q60860
Entrez ID: 17001
|
Does Knockout of Hpse2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Hpse2
|
phagocytosis
|
macrophage
|
Gene: Hpse2 (heparanase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extracellular matrix organization, positive regulation of cell population proliferation; MF: heparan sulfate proteoglycan binding, hydrolase activity, acting on glycosyl bonds; CC: extracellular matrix, extracellular region, extracellular space, membrane
Pathways: Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG degradation, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Proteoglycans in cancer - Mus musculus (mouse)
UniProt: B2RY83
Entrez ID: 545291
|
Does Knockout of Crebl2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Crebl2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Crebl2 (cAMP responsive element binding protein-like 2)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including positive regulation of D-glucose import; positive regulation of metabolic process; and protein stabilization. Located in nucleus. Orthologous to human CREBL2 (cAMP responsive element binding protein like 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, positive regulation of D-glucose import, positive regulation of DNA-templated transcription, positive regulation of fat cell differentiation, positive regulation of lipid biosynthetic process, positive regulation of peptidyl-serine phosphorylation, protein stabilization, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, protein binding; CC: nucleus
Pathways:
UniProt: Q32M00
Entrez ID: 232430
|
Does Knockout of Foxq1 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Foxq1
|
phagocytosis
|
macrophage
|
Gene: Foxq1 (forkhead box Q1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, hair follicle morphogenesis, morphogenesis of an epithelium, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding
Pathways:
UniProt: O70220
Entrez ID: 15220
|
Does Knockout of Dpp7 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Dpp7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dpp7 (dipeptidylpeptidase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lysosomal protein catabolic process, protein catabolic process, proteolysis; MF: aminopeptidase activity, dipeptidyl-peptidase activity, hydrolase activity, peptidase activity, serine-type exopeptidase activity, serine-type peptidase activity; CC: Golgi apparatus, cytoplasmic vesicle, extracellular region, lysosome, vesicle
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q9ET22
Entrez ID: 83768
|
Does Knockout of Dnajb12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Dnajb12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dnajb12 (DnaJ heat shock protein family (Hsp40) member B12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, cellular response to misfolded protein, protein folding, protein-containing complex assembly; MF: Hsp70 protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9QYI4
Entrez ID: 56709
|
Does Knockout of Prpf3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Prpf3
|
cell cycle progression
|
breast epithelium
|
Gene: Prpf3 (pre-mRNA processing factor 3)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to be located in Cajal body; cytosol; and nuclear speck. Predicted to be part of U2-type precatalytic spliceosome and U4/U6 x U5 tri-snRNP complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; olfactory epithelium; and retina. Used to study retinitis pigmentosa 18. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 18. Orthologous to human PRPF3 (pre-mRNA processing factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal tri-snRNP complex assembly; MF: identical protein binding; CC: Cajal body, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, cytosol, nuclear speck, nucleoplasm, nucleus, protein-containing complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q922U1
Entrez ID: 70767
|
Does Knockout of Scgb1b3 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Scgb1b3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Scgb1b3 (secretoglobin, family 1B, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, steroid binding; CC: extracellular region
Pathways:
UniProt: J3QJY4
Entrez ID: 384585
|
Does Knockout of Psg21 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Psg21
|
response to virus
|
Microglial Cell Line
|
Gene: Psg21 (pregnancy-specific beta-1-glycoprotein 21)
Type: protein-coding
Summary: Predicted to be involved in T cell activation and immune response. Predicted to be located in apical plasma membrane and cytosol. Predicted to be active in external side of plasma membrane. Is expressed in labyrinthine zone. Orthologous to human CEACAM21 (CEA cell adhesion molecule 21). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: T cell activation, female pregnancy, immune response; CC: cellular_component, external side of plasma membrane
Pathways:
UniProt: S4R1D2, Q9DAV5
Entrez ID: 72242
|
Does Knockout of Fsd1l in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Fsd1l
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fsd1l (fibronectin type III and SPRY domain containing 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BYN5
Entrez ID: 319636
|
Does Knockout of Gcm1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Gcm1
|
phagocytosis
|
macrophage
|
Gene: Gcm1 (glial cells missing homolog 1)
Type: protein-coding
Summary: Enables DNA binding activity and zinc ion binding activity. Acts upstream of or within several processes, including astrocyte fate commitment; embryonic placenta development; and positive regulation of syncytium formation by plasma membrane fusion. Located in nucleus. Is expressed in several structures, including extraembryonic component; metanephros; pancreas; placenta; and thymus. Orthologous to human GCM1 (glial cells missing transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: astrocyte fate commitment, branching involved in labyrinthine layer morphogenesis, cell differentiation involved in embryonic placenta development, gliogenesis, positive regulation of DNA-templated transcription, positive regulation of syncytium formation by plasma membrane fusion, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell differentiation involved in embryonic placenta development, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone deacetylase binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus, transcription regulator complex
Pathways: Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse)
UniProt: P70348
Entrez ID: 14531
|
Does Knockout of Vmn1r228 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Vmn1r228
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Vmn1r228 (vomeronasal 1 receptor 228)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R2A7
Entrez ID: 171226
|
Does Knockout of Miga1 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Miga1
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Miga1 (mitoguardin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial fusion; MF: protein heterodimerization activity, protein homodimerization activity; CC: membrane, mitochondrial outer membrane, mitochondrion, plasma membrane
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA
UniProt: Q4QQM5
Entrez ID: 215708
|
Does Knockout of Rom1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Rom1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rom1 (rod outer segment membrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye photoreceptor cell differentiation, cell adhesion, detection of light stimulus involved in visual perception, photoreceptor cell outer segment organization, protein heterooligomerization, protein homooligomerization, protein localization to photoreceptor outer segment, regulation of gene expression, response to light stimulus, retina development in camera-type eye, retina morphogenesis in camera-type eye, retina vasculature development in camera-type eye, visual perception; MF: protein binding, protein homodimerization activity; CC: cell projection, membrane, photoreceptor outer segment, photoreceptor outer segment membrane, plasma membrane
Pathways:
UniProt: P32958
Entrez ID: 19881
|
Does Knockout of Rnaseh2b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Rnaseh2b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rnaseh2b (ribonuclease H2, subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, in utero embryonic development, mismatch repair, negative regulation of gene expression, nucleobase-containing compound metabolic process, positive regulation of fibroblast proliferation, regulation of DNA damage checkpoint, regulation of G2/M transition of mitotic cell cycle, ribonucleotide metabolic process; CC: nucleoplasm, nucleus, ribonuclease H2 complex
Pathways: DNA replication - Mus musculus (mouse)
UniProt: Q80ZV0
Entrez ID: 67153
|
Does Knockout of Abhd15 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Abhd15
|
phagocytosis
|
macrophage
|
Gene: Abhd15 (abhydrolase domain containing 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, lipid catabolic process, lipid metabolic process; MF: monoacylglycerol lipase activity, protein binding, short-chain carboxylesterase activity
Pathways:
UniProt: Q5F2F2
Entrez ID: 67477
|
Does Knockout of Adam6a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Adam6a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Adam6a (a disintegrin and metallopeptidase domain 6A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: integrin-mediated signaling pathway, male gonad development, proteolysis; MF: metalloendopeptidase activity, metallopeptidase activity, molecular_function; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, protein-containing complex, sperm head plasma membrane
Pathways:
UniProt: B2RSY5
Entrez ID: 238406
|
Does Knockout of Gm5283 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Gm5283
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Gm5283 (predicted gene 5283)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Nr4a3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Nr4a3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nr4a3 (nuclear receptor subfamily 4, group A, member 3)
Type: protein-coding
Summary: This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: adult behavior, axon guidance, cellular respiration, cellular response to catecholamine stimulus, cellular response to corticotropin-releasing hormone stimulus, cellular response to leptin stimulus, common myeloid progenitor cell proliferation, energy homeostasis, fat cell differentiation, gastrulation, hippocampus development, inner ear morphogenesis, intracellular receptor signaling pathway, intracellular signal transduction, mast cell degranulation, mesoderm formation, negative regulation of neuron apoptotic process, negative regulation of smooth muscle cell apoptotic process, negative regulation of transcription by RNA polymerase II, neuromuscular process controlling balance, platelet-derived growth factor receptor signaling pathway, positive regulation of D-glucose transmembrane transport, positive regulation of DNA-templated transcription, positive regulation of cardiac muscle hypertrophy, positive regulation of cell cycle, positive regulation of dendritic cell apoptotic process, positive regulation of epithelial cell proliferation, positive regulation of feeding behavior, positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway, positive regulation of mast cell cytokine production, positive regulation of monocyte aggregation, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of smooth muscle cell proliferation, regulation of transcription by RNA polymerase II, regulation of type B pancreatic cell proliferation, response to hydrogen peroxide, semicircular canal morphogenesis, vestibular reflex; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cAMP response element binding, double-stranded DNA binding, histone acetyltransferase binding, metal ion binding, nuclear glucocorticoid receptor binding, nuclear receptor activity, protein homodimerization activity, protein kinase binding, sequence-specific DNA binding, transcription coactivator binding, zinc ion binding; CC: nucleus, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q9QZB6
Entrez ID: 18124
|
Does Knockout of Tex101 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Tex101
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Tex101 (testis expressed gene 101)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: basophil activation, binding of sperm to zona pellucida, fertilization, flagellated sperm motility, regulation of cytosolic calcium ion concentration, regulation of flagellated sperm motility; CC: acrosomal membrane, acrosomal vesicle, cell surface, cytoplasmic vesicle, extracellular region, membrane, membrane raft, plasma membrane, plasma membrane raft, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q9JMI7
Entrez ID: 56746
|
Does Knockout of Epb42 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Epb42
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Epb42 (erythrocyte membrane protein band 4.2)
Type: protein-coding
Summary: The protein encoded by this gene is the key component of a macromolecular complex involved in the structure of erythrocytes. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: cell morphogenesis, erythrocyte maturation, hemoglobin metabolic process, monoatomic ion homeostasis, multicellular organismal-level iron ion homeostasis, regulation of cell shape, spleen development; MF: protein-glutamine gamma-glutamyltransferase activity; CC: ankyrin-1 complex, cell periphery, cortical cytoskeleton, cytoplasm, cytoskeleton, membrane, plasma membrane
Pathways:
UniProt: P49222
Entrez ID: 13828
|
Does Knockout of Kifc3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Kifc3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Kifc3 (kinesin family member C3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, epithelial cell-cell adhesion, microtubule-based movement, microtubule-based process, zonula adherens maintenance; MF: ATP binding, identical protein binding, microtubule binding, microtubule motor activity, minus-end-directed microtubule motor activity, nucleotide binding, protein binding; CC: Golgi apparatus, adherens junction, anchoring junction, centrosome, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, kinesin complex, membrane, microtubule, microtubule cytoskeleton, zonula adherens
Pathways:
UniProt: O35231
Entrez ID: 16582
|
Does Knockout of Lypd4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Lypd4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Lypd4 (Ly6/Plaur domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, biological_process, single fertilization, sperm migration through the uterotubal junction; CC: acrosomal vesicle, membrane, plasma membrane, plasma membrane raft, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q8BVP6
Entrez ID: 232973
|
Does Knockout of Il1rl1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Il1rl1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Il1rl1 (interleukin 1 receptor-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inflammatory response, interleukin-33-mediated signaling pathway, macrophage differentiation, negative regulation of T-helper 1 type immune response, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cell population proliferation, negative regulation of type II interferon production, positive regulation of chemokine production, positive regulation of inflammatory response, positive regulation of interleukin-5 production, positive regulation of macrophage activation, regulation of inflammatory response, response to peptide, response to wounding, signal transduction; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, hydrolase activity, interleukin-1 receptor activity, interleukin-33 binding, interleukin-33 receptor activity, protein binding; CC: cell surface, cytosol, external side of plasma membrane, extracellular matrix, extracellular region, extracellular space, focal adhesion, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-1 family signaling, Interleukin-33 signaling, Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Signal Transduction, Signaling by Interleukins
UniProt: P14719
Entrez ID: 17082
|
Does Knockout of Onecut2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Onecut2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Onecut2 (one cut domain, family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, cell fate commitment, cilium assembly, endocrine pancreas development, epithelial cell development, liver development, negative regulation of transforming growth factor beta receptor signaling pathway, pancreas development, peripheral nervous system neuron development, positive regulation of mesenchymal stem cell migration, positive regulation of transcription by RNA polymerase II, regulation of cell-matrix adhesion, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: actin cytoskeleton, nucleoplasm, nucleus
Pathways:
UniProt: Q6XBJ3
Entrez ID: 225631
|
Does Knockout of S100a5 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
S100a5
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: S100a5 (S100 calcium binding protein A5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, calcium-dependent protein binding, copper ion binding, metal ion binding, molecular_function, protein homodimerization activity, transition metal ion binding, zinc ion binding; CC: neuronal cell body, nucleus
Pathways:
UniProt: P63084
Entrez ID: 20199
|
Does Knockout of Usp10 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Usp10
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Usp10 (ubiquitin specific peptidase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, autophagy, cellular response to interleukin-1, chromatin remodeling, monoubiquitinated protein deubiquitination, negative regulation of canonical NF-kappaB signal transduction, negative regulation of stress granule assembly, protein deubiquitination, protein monoubiquitination, proteolysis, regulation of autophagy, regulation of protein stability, rescue of stalled ribosome, ribosome-associated ubiquitin-dependent protein catabolic process, stress granule assembly; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, molecular function inhibitor activity, p53 binding, peptidase activity, protein binding, transmembrane transporter binding; CC: cytoplasm, cytosol, cytosolic ribosome, early endosome, endosome, intermediate filament cytoskeleton, nucleoplasm, nucleus, protein-containing complex
Pathways: DNA Damage Bypass, DNA Repair, Deubiquitination, Metabolism of proteins, Post-translational protein modification, Termination of translesion DNA synthesis, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Ub-specific processing proteases
UniProt: P52479
Entrez ID: 22224
|
Does Knockout of Prss8 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Prss8
|
phagocytosis
|
macrophage
|
Gene: Prss8 (serine protease 8 (prostasin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of sodium ion transmembrane transport, positive regulation of sodium ion transport, proteolysis, transepithelial transport; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity, sodium channel regulator activity; CC: external side of plasma membrane, extracellular region, extracellular space, membrane, membrane raft, plasma membrane
Pathways:
UniProt: A0A0U1RQA6, Q99L44
Entrez ID: 76560
|
Does Knockout of B3galt2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
B3galt2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: B3galt2 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: galactosylceramide biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, protein O-linked glycosylation, protein glycosylation; MF: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Blood group systems biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: O54905
Entrez ID: 26878
|
Does Knockout of Pop5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Pop5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pop5 (processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae))
Type: protein-coding
Summary: Enables ribonuclease P activity. Acts upstream of or within tRNA processing. Part of nucleolar ribonuclease P complex. Is expressed in Meckel's cartilage and skeleton. Orthologous to human POP5 (POP5 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: ribonuclease MRP activity, ribonuclease P RNA binding, ribonuclease P activity; CC: multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonuclease MRP complex, ribonuclease P complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9DB28
Entrez ID: 117109
|
Does Knockout of Prdm13 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Prdm13
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Prdm13 (PR domain containing 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GABAergic neuron differentiation, chromatin remodeling, hypothalamus cell differentiation, methylation, negative regulation of transcription by RNA polymerase II, neurogenesis, regulation of gene expression; MF: DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone methyltransferase activity, metal ion binding, methyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: nucleus
Pathways:
UniProt: E9PZZ1
Entrez ID: 230025
|
Does Knockout of Cmbl in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Cmbl
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cmbl (carboxymethylenebutenolidase homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, molecular_function; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Metabolism, Phase I - Functionalization of compounds
UniProt: Q8R1G2
Entrez ID: 69574
|
Does Knockout of Jagn1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Jagn1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Jagn1 (jagunal homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to fungus, endoplasmic reticulum organization, granulocyte colony-stimulating factor signaling pathway, immune system process, insulin metabolic process, insulin secretion, negative regulation of insulin secretion involved in cellular response to glucose stimulus, neutrophil differentiation, neutrophil mediated immunity, neutrophil migration, protein transport, response to endoplasmic reticulum stress, response to glucose, vesicle-mediated transport; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q5XKN4
Entrez ID: 67767
|
Does Knockout of Foxn4 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Foxn4
|
phagocytosis
|
macrophage
|
Gene: Foxn4 (forkhead box N4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amacrine cell differentiation, atrioventricular canal development, heart looping, nervous system development, neuron fate commitment, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of heart contraction, retina layer formation, ventral spinal cord interneuron differentiation, ventral spinal cord interneuron fate commitment; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, chromatin binding, cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q8K3Q3
Entrez ID: 116810
|
Does Knockout of Serping1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Serping1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Serping1 (serine (or cysteine) peptidase inhibitor, clade G, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood coagulation, fibrinolysis, hemostasis, negative regulation of complement activation, lectin pathway; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Formation of Fibrin Clot (Clotting Cascade), Hemostasis, Immune System, Innate Immune System, Intrinsic Pathway of Fibrin Clot Formation, Pertussis - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Regulation of Complement cascade, Response to elevated platelet cytosolic Ca2+
UniProt: P97290
Entrez ID: 12258
|
Does Knockout of Kcp in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Kcp
|
response to virus
|
Microglial Cell Line
|
Gene: Kcp (kielin/chordin-like protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hematopoietic progenitor cell differentiation, positive regulation of BMP signaling pathway; CC: extracellular region, extracellular space
Pathways:
UniProt: Q3U492
Entrez ID: 333088
|
Does Knockout of Fbxl12 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Fbxl12
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fbxl12 (F-box and leucine-rich repeat protein 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination, ubiquitin-dependent protein catabolic process; CC: cytoplasm, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9EPX5
Entrez ID: 30843
|
Does Knockout of Asb15 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Asb15
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Asb15 (ankyrin repeat and SOCS box-containing 15)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; and protein targeting to chloroplast. Predicted to be active in nucleus. Is expressed in genitourinary system; quadriceps femoris muscle; thoracic segment skeleton; and tongue. Orthologous to human ASB15 (ankyrin repeat and SOCS box containing 15). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: biological_process, establishment or maintenance of cell polarity, intracellular signal transduction, protein ubiquitination, regulation of Wnt signaling pathway; MF: molecular_function, protein binding
Pathways:
UniProt: Q8VHS6
Entrez ID: 78910
|
Does Knockout of C1qtnf7 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
C1qtnf7
|
cell cycle progression
|
breast epithelium
|
Gene: C1qtnf7 (C1q and tumor necrosis factor related protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, protein binding; CC: collagen trimer, extracellular region, extracellular space
Pathways:
UniProt: Q8BVD7
Entrez ID: 109323
|
Does Knockout of Rnf149 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Rnf149
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rnf149 (ring finger protein 149)
Type: protein-coding
Summary: Enables ubiquitin protein ligase activity. Acts upstream of or within cellular response to xenobiotic stimulus; negative regulation of MAPK cascade; and regulation of protein stability. Predicted to be located in membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and late endosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human RNF149 (ring finger protein 149). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to xenobiotic stimulus, negative regulation of MAPK cascade, protein ubiquitination, regulation of protein stability, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, endoplasmic reticulum, late endosome, membrane
Pathways:
UniProt: Q3U2C5
Entrez ID: 67702
|
Does Knockout of Ripor1 in Microglial Cell Line causally result in cell proliferation?
| 0
| 1,358
|
Knockout
|
Ripor1
|
cell proliferation
|
Microglial Cell Line
|
Gene: Ripor1 (RHO family interacting cell polarization regulator 1)
Type: protein-coding
Summary: Predicted to enable 14-3-3 protein binding activity. Predicted to be involved in several processes, including establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange factor activity; and negative regulation of Rho protein signal transduction. Located in cytoplasm. Is expressed in several structures, including adrenal gland; genitourinary system; hemolymphoid system; liver; and lung. Orthologous to human RIPOR1 (RHO family interacting cell polarization regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Rho protein signal transduction, cellular response to chemokine, cellular response to starvation, establishment of Golgi localization, negative regulation of Rho protein signal transduction, positive regulation of cell migration, positive regulation of intracellular protein transport, protein localization to Golgi apparatus, response to wounding; MF: 14-3-3 protein binding; CC: Golgi apparatus, cell leading edge, cytoplasm, cytosol, membrane
Pathways:
UniProt: Q68FE6
Entrez ID: 75687
|
Does Knockout of Il16 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Il16
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Il16 (interleukin 16)
Type: protein-coding
Summary: Enables cytokine activity. Involved in cytokine-mediated signaling pathway. Acts upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutrophil activation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including foregut; jaw; limb; respiratory system; and vibrissa. Human ortholog(s) of this gene implicated in asthma; colorectal adenocarcinoma; and prostate cancer. Orthologous to human IL16 (interleukin 16). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: chemotaxis, cytokine-mediated signaling pathway, immune system process, induction of positive chemotaxis, leukocyte chemotaxis, positive regulation of chemokine production, positive regulation of gene expression, positive regulation of inflammatory response, positive regulation of interleukin-1 alpha production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of neutrophil activation, regulation of calcium ion transport; MF: CD4 receptor binding, cytokine activity, protein binding, signaling receptor binding; CC: Flemming body, cytoplasm, cytosol, extracellular matrix, extracellular region, extracellular space, focal adhesion, nuclear speck, nucleus, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Other interleukin signaling, Signaling by Interleukins
UniProt: O54824
Entrez ID: 16170
|
Does Knockout of Bicral in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Bicral
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Bicral (BRD4 interacting chromatin remodeling complex associated protein like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, negative regulation of cell differentiation, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of stem cell population maintenance, regulation of transcription by RNA polymerase II; CC: GBAF complex, SWI/SNF complex, chromatin
Pathways: ATP-dependent chromatin remodelers, Chromatin organization, Formation of the non-canonical BAF (ncBAF) complex, SWI/SNF chromatin remodelers
UniProt: Q8CHH5
Entrez ID: 210982
|
Does Knockout of Psg22 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Psg22
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Psg22 (pregnancy-specific beta-1-glycoprotein 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, female pregnancy, positive regulation of angiogenesis, positive regulation of cytokine production, positive regulation of macrophage cytokine production, positive regulation of transforming growth factor beta production, regulation of immune system process, signal transduction; MF: protein tyrosine kinase binding, syndecan binding; CC: cell surface, extracellular region, plasma membrane
Pathways: Cell surface interactions at the vascular wall, Hemostasis, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q810J1
Entrez ID: 243862
|
Does Knockout of Cenpq in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Cenpq
|
phagocytosis
|
macrophage
|
Gene: Cenpq (centromere protein Q)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, metaphase chromosome alignment, positive regulation of protein localization to kinetochore; CC: actin cytoskeleton, chromosome, chromosome, centromeric region, inner kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CPQ5
Entrez ID: 83815
|
Does Knockout of Acsf2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Acsf2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Acsf2 (acyl-CoA synthetase family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, lipid metabolic process, small molecule metabolic process; MF: ATP binding, catalytic activity, ligase activity, medium-chain fatty acid-CoA ligase activity, nucleotide binding; CC: mitochondrion
Pathways: Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation
UniProt: Q8VCW8
Entrez ID: 264895
|
Does Knockout of Auh in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Auh
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Auh (AU RNA binding protein/enoyl-coenzyme A hydratase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-leucine catabolic process, branched-chain amino acid catabolic process, fatty acid beta-oxidation; MF: RNA binding, catalytic activity, enoyl-CoA hydratase activity, itaconyl-CoA hydratase activity, lyase activity, mRNA 3'-UTR binding, methylglutaconyl-CoA hydratase activity; CC: mitochondrion
Pathways: Branched-chain amino acid catabolism, Leucine Catabolism, Metabolism, Metabolism of amino acids and derivatives, Valine, leucine and isoleucine degradation - Mus musculus (mouse), leucine degradation I
UniProt: Q9JLZ3
Entrez ID: 11992
|
Does Knockout of Zfp473 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Zfp473
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp473 (zinc finger protein 473)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA 3'-end processing by stem-loop binding and cleavage, negative regulation of DNA-templated transcription, negative regulation of transcription initiation by RNA polymerase II, regulation of DNA-templated transcription, regulation of anatomical structure morphogenesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: Cajal body, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of RNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs
UniProt: Q8BI67
Entrez ID: 243963
|
Does Knockout of Il17c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Il17c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Il17c (interleukin 17C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inflammatory response, neutrophil differentiation, positive regulation of cytokine production involved in inflammatory response, signal transduction; MF: cytokine activity; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse)
UniProt: Q8K4C5
Entrez ID: 234836
|
Does Knockout of Ampd2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Ampd2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Ampd2 (adenosine monophosphate deaminase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMP metabolic process, ATP metabolic process, GMP salvage, GTP metabolic process, IMP biosynthetic process, IMP salvage, cholesterol homeostasis, cyclic purine nucleotide metabolic process, energy homeostasis, nucleotide metabolic process, podocyte development, purine ribonucleoside monophosphate biosynthetic process; MF: AMP deaminase activity, deaminase activity, hydrolase activity, identical protein binding, metal ion binding; CC: cytosol
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide salvage, Purine metabolism - Mus musculus (mouse), Purine salvage
UniProt: Q9DBT5
Entrez ID: 109674
|
Does Knockout of Best3 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Best3
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Best3 (bestrophin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, chloride transport, inorganic anion transport, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of monoatomic ion transport; MF: channel activity, chloride channel activity, intracellularly calcium-gated chloride channel activity, ligand-gated monoatomic anion channel activity, metal ion binding; CC: chloride channel complex, membrane, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q6H1V1
Entrez ID: 382427
|
Does Knockout of Nkx2-2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Nkx2-2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Nkx2-2 (NK2 homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: astrocyte differentiation, cell development, cell differentiation, central nervous system neuron differentiation, digestive tract development, endocrine pancreas development, negative regulation of neuron differentiation, nervous system development, neuroendocrine cell differentiation, neuron fate specification, oligodendrocyte development, optic nerve development, pancreatic A cell fate commitment, pancreatic PP cell fate commitment, positive regulation of epithelial cell differentiation, positive regulation of gene expression, positive regulation of neuron differentiation, positive regulation of oligodendrocyte differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to glucose, response to progesterone, smoothened signaling pathway, spinal cord motor neuron differentiation, spinal cord oligodendrocyte cell differentiation, spinal cord oligodendrocyte cell fate specification, type B pancreatic cell development, type B pancreatic cell differentiation, type B pancreatic cell fate commitment, ventral spinal cord interneuron fate determination; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding; CC: nucleus
Pathways: Maturity onset diabetes of the young - Mus musculus (mouse)
UniProt: P42586
Entrez ID: 18088
|
Does Knockout of Tpcn1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Tpcn1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tpcn1 (two pore channel 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, endocytosis involved in viral entry into host cell, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of autophagy, sodium ion transmembrane transport, transmembrane transport; MF: NAADP-sensitive calcium-release channel activity, calcium channel activity, identical protein binding, intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity, ligand-gated sodium channel activity, monoatomic ion channel activity, phosphatidylinositol-3,5-bisphosphate binding, protein homodimerization activity, syntaxin binding, voltage-gated channel activity, voltage-gated sodium channel activity; CC: early endosome membrane, endolysosome, endosome, endosome membrane, lysosomal membrane, lysosome, membrane, monoatomic ion channel complex, recycling endosome membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q9EQJ0
Entrez ID: 252972
|
Does Knockout of Zfp93 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Zfp93
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Zfp93 (zinc finger protein 93)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q61116
Entrez ID: 22755
|
Does Knockout of Cacul1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Cacul1
|
cell proliferation
|
Regulatory T cell
|
Gene: Cacul1 (CDK2 associated, cullin domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of protein kinase activity, ubiquitin-dependent protein catabolic process; MF: protein kinase binding, ubiquitin protein ligase binding
Pathways:
UniProt: Q8R0X2
Entrez ID: 78832
|
Does Knockout of Fnbp4 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Fnbp4
|
cell proliferation
|
Regulatory T cell
|
Gene: Fnbp4 (formin binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6ZQ03
Entrez ID: 55935
|
Does Knockout of Dok5 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Dok5
|
response to bacteria
|
renal medulla cell line
|
Gene: Dok5 (docking protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, neuron differentiation, positive regulation of MAPK cascade, regulation of neurotrophin TRK receptor signaling pathway
Pathways: Axon guidance, Developmental Biology, Nervous system development, RET signaling
UniProt: Q91ZM9
Entrez ID: 76829
|
Does Knockout of Ndufa7 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ndufa7
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ndufa7 (NADH:ubiquinone oxidoreductase subunit A7)
Type: protein-coding
Summary: This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. Complex I has been biochemically separated into four fractions. The bovine ortholog of this protein has been reported to be part of the I-lambda fraction, which forms the extrinsic globular domain. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. Pseudogenes of this gene are located on chromosomes 7 and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
Gene Ontology: BP: ATP synthesis coupled electron transport, aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9Z1P6
Entrez ID: 66416
|
Does Knockout of Txlng in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Txlng
|
response to bacteria
|
renal medulla cell line
|
Gene: Txlng (taxilin gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of bone mineralization, regulation of cell cycle, regulation of cell cycle process; MF: DNA-binding transcription factor binding, protein binding, syntaxin binding; CC: cytoplasm, cytosol, membrane, nuclear membrane, nucleus
Pathways:
UniProt: Q8BHN1
Entrez ID: 353170
|
Does Knockout of Ascc3 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,525
|
Knockout
|
Ascc3
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ascc3 (activating signal cointegrator 1 complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CAT tailing, DNA alkylation repair, DNA damage response, DNA repair, protein monoubiquitination, protein ufmylation, rescue of stalled ribosome, ribosome disassembly, ribosome-associated ubiquitin-dependent protein catabolic process; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, helicase activity, hydrolase activity, isomerase activity, nucleic acid binding, nucleotide binding; CC: DNA repair complex, RQC-trigger complex, cytoplasm, cytosol, cytosolic ribosome, nuclear speck, nucleus
Pathways: Metabolism of proteins, Ribosome-associated quality control, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
UniProt: E9PZJ8
Entrez ID: 77987
|
Does Knockout of Ntng2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Ntng2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ntng2 (netrin G2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to a subclass of the netrin family called netrin-G proteins. Unlike classic netrins, which act as diffusible chemoattractants, netrin-Gs are glycosylphosphatidylinositol-anchored membrane proteins that interact with specific transmembrane proteins. In mouse, this gene is preferentially expressed in the cerebral cortex, habenular nucleus and superior colliculus. Knockout mutant mice display a lack of behavioral startle in response to acoustic stimuli. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: animal organ morphogenesis, axonogenesis, cell differentiation, modulation of chemical synaptic transmission, nervous system development, postsynaptic specialization assembly, regulation of neuron migration, regulation of neuron projection arborization, regulation of neuron projection development, regulation of presynapse assembly, synaptic membrane adhesion, tissue development; CC: Schaffer collateral - CA1 synapse, axon, glutamatergic synapse, membrane, plasma membrane, presynaptic active zone membrane, side of membrane
Pathways: Axon guidance - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse)
UniProt: Q8R4F1
Entrez ID: 171171
|
Does Knockout of Tpra1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Tpra1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tpra1 (transmembrane protein, adipocyte asscociated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, embryonic cleavage, negative regulation of mitotic cell cycle phase transition; CC: membrane, plasma membrane
Pathways:
UniProt: Q99MU1
Entrez ID: 24100
|
Does Knockout of Ccdc171 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Ccdc171
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ccdc171 (coiled-coil domain containing 171)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q1U1
Entrez ID: 320226
|
Does Knockout of Sdccag8 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Sdccag8
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sdccag8 (serologically defined colon cancer antigen 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, centrosome cycle, establishment of cell polarity, microtubule organizing center organization, neuron migration, regulation of cilium assembly, tube formation; CC: anchoring junction, cell projection, cell-cell junction, centriolar satellite, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, nucleoplasm, photoreceptor cell cilium
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q80UF4
Entrez ID: 76816
|
Does Knockout of Qprt in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Qprt
|
cell cycle progression
|
breast epithelium
|
Gene: Qprt (quinolinate phosphoribosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' NAD+ biosynthetic process from L-tryptophan, NAD+ biosynthetic process, pyridine nucleotide biosynthetic process, quinolinate catabolic process, quinolinate metabolic process; MF: glycosyltransferase activity, identical protein binding, nicotinate-nucleotide diphosphorylase (carboxylating) activity, pentosyltransferase activity, transferase activity; CC: catalytic complex, cytoplasm, cytosol
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NAD biosynthesis II (from tryptophan), NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nicotinate metabolism
UniProt: Q91X91
Entrez ID: 67375
|
Does Knockout of Trim34b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Trim34b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Trim34b (tripartite motif-containing 34B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, innate immune response, protein ubiquitination, regulation of gene expression; MF: identical protein binding, metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, mitochondrion
Pathways:
UniProt: K7N6K2
Entrez ID: 434218
|
Does Knockout of Lrwd1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Lrwd1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Lrwd1 (leucine-rich repeats and WD repeat domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, chromatin organization, establishment of protein localization to chromatin; MF: chromatin binding, histone H3K27me3 reader activity, methyl-CpG binding; CC: centrosome, chromosome, chromosome, centromeric region, chromosome, telomeric region, cytoplasm, cytoskeleton, kinetochore, nuclear origin of replication recognition complex, nucleolus, nucleoplasm, nucleus, pericentric heterochromatin
Pathways:
UniProt: Q8BUI3
Entrez ID: 71735
|
Does Knockout of Gbgt1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Gbgt1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Gbgt1 (globoside alpha-1,3-N-acetylgalactosaminyltransferase 1)
Type: protein-coding
Summary: Enables globoside alpha-N-acetylgalactosaminyltransferase activity. Predicted to be involved in globoside metabolic process and lipid glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and vesicle. Is expressed in intestine; male reproductive gland or organ; nervous system; and stomach. Orthologous to human GBGT1 (globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: carbohydrate metabolic process, globoside metabolic process, protein glycosylation; MF: globoside alpha-N-acetylgalactosaminyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane, vesicle
Pathways: Glycosphingolipid biosynthesis - globo and isoglobo series - Mus musculus (mouse)
UniProt: Q8VI38
Entrez ID: 227671
|
Does Knockout of Lrrc45 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Lrrc45
|
response to bacteria
|
macrophage
|
Gene: Lrrc45 (leucine rich repeat containing 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, plasma membrane
Pathways:
UniProt: Q8CIM1
Entrez ID: 217366
|
Does Knockout of Tpx2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Tpx2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tpx2 (TPX2, microtubule-associated)
Type: protein-coding
Summary: Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in mitotic spindle assembly and regulation of mitotic spindle organization. Located in axon hillock and spindle. Is expressed in cerebral cortex ventricular layer; large intestine; nephrogenic zone; and small intestine. Orthologous to human TPX2 (TPX2 microtubule nucleation factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: activation of protein kinase activity, apoptotic process, cell division, microtubule nucleation, mitotic spindle assembly, negative regulation of microtubule depolymerization, regulation of mitotic spindle organization, spindle assembly; MF: importin-alpha family protein binding, molecular adaptor activity, protein binding, protein kinase binding, protein serine/threonine kinase activator activity; CC: aster, axon hillock, cytoplasm, cytoskeleton, intercellular bridge, microtubule, microtubule cytoskeleton, mitotic spindle, nucleoplasm, nucleus, spindle, spindle pole
Pathways: AURKA Activation by TPX2, Cell Cycle, Cell Cycle, Mitotic, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, Mitotic G2-G2/M phases, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: A2APB8
Entrez ID: 72119
|
Does Knockout of Sirt6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Sirt6
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Sirt6 (sirtuin 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, Ras protein signal transduction, base-excision repair, cardiac muscle cell differentiation, cellular response to angiotensin, cellular response to endothelin, cellular response to hydrogen peroxide, chromatin organization, chromatin remodeling, circadian regulation of gene expression, determination of adult lifespan, double-strand break repair, gluconeogenesis, glucose homeostasis, glycolytic process, inflammatory response, ketone biosynthetic process, negative regulation of D-glucose import, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of cellular senescence, negative regulation of gene expression, epigenetic, negative regulation of gluconeogenesis, negative regulation of glycolytic process, negative regulation of protein import into nucleus, negative regulation of protein localization to chromatin, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, pericentric heterochromatin formation, positive regulation of blood vessel branching, positive regulation of cellular senescence, positive regulation of chondrocyte proliferation, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair, positive regulation of fat cell differentiation, positive regulation of fibroblast proliferation, positive regulation of gluconeogenesis, positive regulation of insulin secretion, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein export from nucleus, positive regulation of protein localization to chromatin, positive regulation of stem cell differentiation, positive regulation of stem cell population maintenance, positive regulation of stem cell proliferation, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial cell proliferation, post-embryonic cardiac muscle cell growth involved in heart morphogenesis, protein deacetylation, protein delipidation, protein destabilization, protein import into nucleus, protein localization to site of double-strand break, protein poly-ADP-ribosylation, regulation of circadian rhythm, regulation of double-strand break repair via homologous recombination, regulation of lipid catabolic process, regulation of lipid metabolic process, regulation of protein export from nucleus, regulation of protein localization to plasma membrane, regulation of protein secretion, response to UV, response to nutrient levels, subtelomeric heterochromatin formation, transcription pausing by RNA polymerase II, transposable element silencing; MF: DNA binding, DNA damage sensor activity, NAD+ binding, NAD+-protein mono-ADP-ribosyltransferase activity, NAD+-protein-arginine ADP-ribosyltransferase activity, NAD+-protein-lysine ADP-ribosyltransferase activity, NAD-dependent protein demyristoylase activity, NAD-dependent protein depalmitoylase activity, NAD-dependent protein lysine deacetylase activity, RNA binding, TORC2 complex binding, acyltransferase activity, chromatin DNA binding, chromatin binding, damaged DNA binding, enzyme regulator activity, glycosyltransferase activity, histone H3K18 deacetylase activity, NAD-dependent, histone H3K56 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, hydrolytic mechanism, histone deacetylase activity, NAD-dependent, histone deacetylase regulator activity, lncRNA binding, metal ion binding, nucleosome binding, nucleotidyltransferase activity, protein homodimerization activity, protein lysine deacetylase activity, transcription corepressor activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, chromosome, subtelomeric region, chromosome, telomeric region, endoplasmic reticulum, nucleolus, nucleoplasm, nucleus, pericentric heterochromatin, site of DNA damage, site of double-strand break
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Processing of DNA double-strand break ends, Thermogenesis - Mus musculus (mouse)
UniProt: P59941
Entrez ID: 50721
|
Does Knockout of Lsr in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Lsr
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lsr (lipolysis stimulated lipoprotein receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial structure maintenance, establishment of blood-brain barrier, establishment of skin barrier, lipoprotein transport, liver development, protein localization to tricellular tight junction, regulation of lipid metabolic process, tricellular tight junction assembly, vesicle-mediated transport; MF: lipoprotein particle receptor activity, low-density lipoprotein particle binding, protein binding; CC: anchoring junction, bicellular tight junction, cell junction, chylomicron, low-density lipoprotein particle, membrane, plasma membrane, tight junction, tricellular tight junction, very-low-density lipoprotein particle
Pathways:
UniProt: Q99KG5
Entrez ID: 54135
|
Does Knockout of Myocd in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Myocd
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Myocd (myocardin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle cell differentiation, cardiac muscle cell myoblast differentiation, cardiac vascular smooth muscle cell differentiation, cardiac ventricle development, cell growth involved in cardiac muscle cell development, chromatin organization, digestive tract development, ductus arteriosus closure, heart development, hepatic stellate cell activation, lung alveolus development, negative regulation of amyloid-beta clearance, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell adhesion molecule production, negative regulation of cell population proliferation, negative regulation of myotube differentiation, negative regulation of platelet-derived growth factor receptor-beta signaling pathway, negative regulation of skeletal muscle cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell migration, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of DNA-templated transcription, positive regulation of cardiac muscle cell differentiation, positive regulation of cardiac muscle hypertrophy, positive regulation of cell population proliferation, positive regulation of epithelial to mesenchymal transition, positive regulation of gene expression, positive regulation of miRNA transcription, positive regulation of smooth muscle cell differentiation, positive regulation of smooth muscle contraction, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of vascular associated smooth muscle cell migration, regulation of cell growth by extracellular stimulus, regulation of muscle cell differentiation, regulation of myoblast differentiation, regulation of phenotypic switching, regulation of smooth muscle cell differentiation, regulation of transcription by RNA polymerase II, regulation of vascular associated smooth muscle cell migration, response to hypoxia, smooth muscle cell differentiation, transcription initiation-coupled chromatin remodeling, urinary bladder development, uterus development, vascular associated smooth muscle cell differentiation, vasculogenesis, ventricular cardiac muscle cell differentiation; MF: DNA-binding transcription factor binding, R-SMAD binding, RNA polymerase II-specific DNA-binding transcription factor binding, histone acetyltransferase binding, histone deacetylase binding, protein binding, transcription coactivator activity; CC: SRF-myogenin-E12 complex, chromatin, cytoplasm, nuclear speck, nucleoplasm, nucleus, protein-DNA complex
Pathways:
UniProt: Q8VIM5
Entrez ID: 214384
|
Does Knockout of Trdn in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Trdn
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Trdn (triadin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, endoplasmic reticulum membrane organization, establishment of localization in cell, heart contraction, intracellular calcium ion homeostasis, negative regulation of release of sequestered calcium ion into cytosol, positive regulation of release of sequestered calcium ion into cytosol, regulation of cardiac muscle cell membrane potential, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of sequestering of calcium ion, release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, response to bacterium; MF: protein binding, protein-macromolecule adaptor activity, signaling receptor binding; CC: calcium channel complex, cytosol, junctional membrane complex, junctional sarcoplasmic reticulum membrane, membrane, nucleoplasm, plasma membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Ion channel transport, Ion homeostasis, Muscle contraction, Stimuli-sensing channels, Transport of small molecules
UniProt: E9Q9K5
Entrez ID: 76757
|
Does Knockout of Mtor in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Mtor
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mtor (mechanistic target of rapamycin kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' pyrimidine nucleobase biosynthetic process, DNA damage response, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, T-helper 1 cell lineage commitment, TOR signaling, TORC1 signaling, TORC2 signaling, antibacterial innate immune response, autophagosome assembly, behavioral response to pain, cardiac cell development, cardiac muscle cell development, cardiac muscle contraction, cardiac muscle tissue development, cell projection organization, cellular response to L-leucine, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to hypoxia, cellular response to insulin stimulus, cellular response to leucine starvation, cellular response to methionine, cellular response to nutrient, cellular response to nutrient levels, cellular response to osmotic stress, cellular response to starvation, cytoplasmic translation, cytoskeleton organization, energy reserve metabolic process, germ cell development, heart morphogenesis, heart valve morphogenesis, inflammatory response, insulin receptor signaling pathway, long-term memory, lysosome organization, mRNA stabilization, maternal process involved in female pregnancy, multicellular organism growth, negative regulation of TORC1 signaling, negative regulation of TORC2 signaling, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of calcineurin-NFAT signaling cascade, negative regulation of cell size, negative regulation of cholangiocyte apoptotic process, negative regulation of innate immune response, negative regulation of insulin receptor signaling pathway, negative regulation of iodide transmembrane transport, negative regulation of lysosome organization, negative regulation of macroautophagy, negative regulation of muscle atrophy, negative regulation of protein localization to nucleus, negative regulation of protein ubiquitination, negative regulation of translational initiation, negative regulation of ubiquitin-dependent protein catabolic process, neuronal action potential, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process, positive regulation of TORC1 signaling, positive regulation of actin filament polymerization, positive regulation of autophagy, positive regulation of biosynthetic process, positive regulation of cell growth, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of cell population proliferation, positive regulation of cell projection organization, positive regulation of cellular senescence, positive regulation of cholangiocyte proliferation, positive regulation of dendritic spine development, positive regulation of eating behavior, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell apoptotic process, positive regulation of epithelial to mesenchymal transition, positive regulation of glial cell proliferation, positive regulation of glycolytic process, positive regulation of granulosa cell proliferation, positive regulation of keratinocyte migration, positive regulation of lamellipodium assembly, positive regulation of lipid biosynthetic process, positive regulation of myotube differentiation, positive regulation of neurogenesis, positive regulation of neuron apoptotic process, positive regulation of neuron maturation, positive regulation of neuron projection development, positive regulation of nitric oxide biosynthetic process, positive regulation of oligodendrocyte differentiation, positive regulation of pentose-phosphate shunt, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of ruffle assembly, positive regulation of skeletal muscle hypertrophy, positive regulation of smooth muscle cell proliferation, positive regulation of stress fiber assembly, positive regulation of striated muscle cell differentiation, positive regulation of transcription by RNA polymerase III, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, positive regulation of translation, positive regulation of translational initiation, positive regulation of ubiquitin-dependent protein catabolic process, positive regulation of wound healing, spreading of epidermal cells, post-embryonic development, protein destabilization, regulation of actin cytoskeleton organization, regulation of autophagosome assembly, regulation of autophagy, regulation of behavior, regulation of brown fat cell differentiation, regulation of carbohydrate metabolic process, regulation of carbohydrate utilization, regulation of cell growth, regulation of cell size, regulation of circadian rhythm, regulation of fatty acid beta-oxidation, regulation of glycogen biosynthetic process, regulation of lipid metabolic process, regulation of locomotor rhythm, regulation of lysosome organization, regulation of membrane permeability, regulation of myelination, regulation of osteoclast differentiation, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of plasma membrane bounded cell projection organization, regulation of response to food, regulation of translation at synapse, modulating synaptic transmission, regulation of translational initiation, response to amino acid, response to cocaine, response to heat, response to insulin, response to nutrient levels, response to virus, social behavior, spinal cord development, ubiquitin-dependent protein catabolic process, visual learning, voluntary musculoskeletal movement; MF: ATP binding, RNA polymerase III type 1 promoter sequence-specific DNA binding, RNA polymerase III type 2 promoter sequence-specific DNA binding, RNA polymerase III type 3 promoter sequence-specific DNA binding, TFIIIC-class transcription factor complex binding, identical protein binding, inositol hexakisphosphate binding, kinase activity, metal ion binding, nucleotide binding, phosphoprotein binding, protein binding, protein domain specific binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, protein-containing complex binding, ribosome binding, transferase activity, transmembrane transporter binding; CC: Golgi apparatus, Golgi membrane, PML body, TORC1 complex, TORC2 complex, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, lysosomal membrane, lysosome, membrane, mitochondrial outer membrane, mitochondrion, neuronal cell body, nuclear envelope, nucleus, phagocytic vesicle, plasma membrane, postsynaptic cytosol, protein-containing complex, serine/threonine protein kinase complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amino acids regulate mTORC1, Amyotrophic lateral sclerosis - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, Cellular response to heat stress, Cellular response to starvation, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Co-stimulation by CD28, Colorectal cancer - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Energy dependent regulation of mTOR by LKB1-AMPK, ErbB signaling pathway - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glioma - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), HSF1-dependent transactivation, Hepatocellular carcinoma - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Immune System, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MTOR signalling, Macroautophagy, MicroRNAs in cancer - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PIP3 activates AKT signaling, PTEN Regulation, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Spinocerebellar ataxia - Mus musculus (mouse), TP53 Regulates Metabolic Genes, Th17 cell differentiation - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional Regulation by TP53, Type II diabetes mellitus - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q9JLN9
Entrez ID: 56717
|
Does Knockout of Hoxb3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Hoxb3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Hoxb3 (homeobox B3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, anterior/posterior pattern specification, cartilage development, definitive hemopoiesis, embryonic skeletal system morphogenesis, face development, glossopharyngeal nerve morphogenesis, hematopoietic progenitor cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neurogenesis, regulation of transcription by RNA polymerase II, rhombomere development, thyroid gland development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P09026
Entrez ID: 15410
|
Does Knockout of Ralgps2 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Ralgps2
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Ralgps2 (Ral GEF with PH domain and SH3 binding motif 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity; CC: cytoplasm, membrane, plasma membrane
Pathways:
UniProt: Q9ERD6
Entrez ID: 78255
|
Does Knockout of Cavin1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Cavin1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cavin1 (caveolae associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription termination, positive regulation of cell motility, protein secretion, rRNA transcription, termination of RNA polymerase I transcription, transcription initiation at RNA polymerase I promoter; MF: RNA binding, identical protein binding, protein binding, rRNA binding, rRNA primary transcript binding; CC: caveola, cytoplasm, cytosol, endoplasmic reticulum, membrane, membrane raft, mitochondrion, nucleus, plasma membrane, protein-containing complex
Pathways: Gene expression (Transcription), RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RNA Polymerase I Transcription, RNA Polymerase I Transcription Termination, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O54724
Entrez ID: 19285
|
Does Knockout of Bmp15 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Bmp15
|
phagocytosis
|
macrophage
|
Gene: Bmp15 (bone morphogenetic protein 15)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Female mice lacking a functional copy of this gene exhibit impaired fertility. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: cell surface receptor protein serine/threonine kinase signaling pathway, positive regulation of DNA-templated transcription; MF: cytokine activity, growth factor activity; CC: cytoplasm, extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), Metabolism of proteins, Ovarian steroidogenesis - Mus musculus (mouse), Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q9Z0L4
Entrez ID: 12155
|
Does Knockout of Slc34a2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Slc34a2
|
cell cycle progression
|
breast epithelium
|
Gene: Slc34a2 (solute carrier family 34 (sodium phosphate), member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: in utero embryonic development, intracellular phosphate ion homeostasis, monoatomic ion transport, phosphate ion transport, response to estrogen, sodium ion transmembrane transport, sodium ion transport, sodium-dependent phosphate transport, transmembrane transport; MF: phosphate ion binding, protein domain specific binding, sodium ion binding, sodium:phosphate symporter activity, symporter activity; CC: apical plasma membrane, brush border, brush border membrane, membrane, microvillus membrane, plasma membrane, vesicle
Pathways: Metabolism of proteins, Mineral absorption - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Sodium-coupled phosphate cotransporters, Surfactant metabolism, Transport of small molecules, Type II Na+/Pi cotransporters
UniProt: Q9DBP0
Entrez ID: 20531
|
Does Knockout of Tagln2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Tagln2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tagln2 (transgelin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, epithelial cell differentiation
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q9WVA4
Entrez ID: 21346
|
Does Knockout of Trmt112 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,285
|
Knockout
|
Trmt112
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trmt112 (tRNA methyltransferase 11-2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA, maturation of SSU-rRNA, peptidyl-glutamine methylation, positive regulation of rRNA processing, rRNA (guanine-N7)-methylation, rRNA methylation, tRNA methylation, transcription initiation-coupled chromatin remodeling; MF: protein binding, protein heterodimerization activity, protein methyltransferase activity, tRNA methyltransferase activator activity; CC: cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex, tRNA (m2G10) methyltransferase complex
Pathways: Biological oxidations, Eukaryotic Translation Termination, Metabolism, Metabolism of proteins, Methylation, Phase II - Conjugation of compounds, Translation
UniProt: Q9DCG9
Entrez ID: 67674
|
Does Knockout of Epha1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Epha1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Epha1 (Eph receptor A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell adhesion, cell surface receptor protein tyrosine kinase signaling pathway, ephrin receptor signaling pathway, negative regulation of cell migration, positive regulation of angiogenesis, positive regulation of cell migration, positive regulation of cell-matrix adhesion, positive regulation of stress fiber assembly, substrate adhesion-dependent cell spreading; MF: ATP binding, ephrin receptor activity, fibronectin binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity; CC: membrane, plasma membrane, receptor complex
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, Nervous system development
UniProt: Q60750
Entrez ID: 13835
|
Does Knockout of Samd4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Samd4
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Samd4 (sterile alpha motif domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of translation, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of translation, regulation of mRNA stability, regulation of postsynapse assembly, regulation of translation; MF: RNA binding, mRNA binding, translation repressor activity; CC: P-body, cell junction, cell projection, cytoplasm, cytosol, dendrite, fibrillar center, glutamatergic synapse, neuron projection, postsynaptic density, synapse
Pathways:
UniProt: Q8CBY1
Entrez ID: 74480
|
Does Knockout of Cdk8 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Cdk8
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Cdk8 (cyclin dependent kinase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of triglyceride metabolic process, positive regulation of transcription by RNA polymerase II, protein ubiquitination, regulation of cell cycle; MF: ATP binding, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin protein ligase activity; CC: CKM complex, cyclin-dependent protein kinase holoenzyme complex, mediator complex, nucleolus, nucleoplasm, nucleus, protein-containing complex, ubiquitin ligase complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: Q8R3L8
Entrez ID: 264064
|
Does Knockout of Npy in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Npy
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Npy (neuropeptide Y)
Type: protein-coding
Summary: This gene encodes a neuropeptide that plays a pivotal role in many physiological functions such as food intake, energy homeostasis, circadian rhythm, and cognition. The encoded protein precursor undergoes proteolytic processing to generate the biologically active peptide. Mice lacking the encoded protein exhibit mild seizures occasionally and become hyperphagic following food deprivation. A deficiency of the encoded protein partially prevents mice lacking leptin from becoming obese. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: adult feeding behavior, antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, central nervous system neuron development, cerebral cortex development, chemical synaptic transmission, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, developmental growth, drinking behavior, feeding behavior, innate immune response, monocyte activation, negative regulation of acute inflammatory response to antigenic stimulus, negative regulation of blood pressure, neuron projection development, neuropeptide signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of appetite, positive regulation of cell population proliferation, positive regulation of cell-substrate adhesion, positive regulation of dopamine metabolic process, positive regulation of eating behavior, positive regulation of nitric oxide metabolic process, regulation of blood pressure, regulation of nerve growth factor production, regulation of presynaptic cytosolic calcium ion concentration, regulation of synaptic vesicle exocytosis, response to yeast, short-day photoperiodism, synaptic signaling via neuropeptide; MF: G protein-coupled receptor binding, hormone activity, neuropeptide Y receptor binding, neuropeptide hormone activity; CC: GABA-ergic synapse, Golgi apparatus, cytoplasm, cytoplasmic vesicle, extracellular region, extracellular space, neuronal dense core vesicle, perikaryon, perinuclear region of cytoplasm, terminal bouton
Pathways: Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Regulation of lipolysis in adipocytes - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: P57774
Entrez ID: 109648
|
Does Knockout of Col9a2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Col9a2
|
response to virus
|
Microglial Cell Line
|
Gene: Col9a2 (collagen, type IX, alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: extracellular matrix structural constituent conferring tensile strength, protein homodimerization activity; CC: collagen trimer, collagen type IX trimer, extracellular matrix, extracellular region
Pathways: ECM-receptor interaction - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: I7HJR1
Entrez ID: 12840
|
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