prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Apeh in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,179 | Knockout | Apeh | cell proliferation | Colonic Cancer Cell Line | Gene: Apeh (acylpeptide hydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid-beta metabolic process, proteolysis; MF: hydrolase activity, identical protein binding, omega peptidase activity, peptidase activity, serine-type endopeptidase activity, serine-type... |
Does Knockout of Tspan11 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Tspan11 | cell cycle progression | breast epithelium | Gene: Tspan11 (tetraspanin 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q9D1D1
Entrez ID: 68498 |
Does Knockout of Nt5c1a in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Nt5c1a | cell proliferation | Melanoma Cell Line | Gene: Nt5c1a (5'-nucleotidase, cytosolic IA)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMP catabolic process, IMP catabolic process, adenosine metabolic process, allantoin metabolic process, amide catabolic process, dAMP catabolic process, dGMP catabolic process, nu... |
Does Knockout of Ltbp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Ltbp1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Ltbp1 (latent transforming growth factor beta binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, coronary vasculature development, establishment of protein localization to extracellular region, positive regulation of collagen biosy... |
Does Knockout of Inf2 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Inf2 | protein/peptide accumulation | Embryonic Cell Line | Gene: Inf2 (inverted formin, FH2 and WH2 domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin nucleation, gene expression, regulation of cellular component size, regulation of mitochondrial fission; MF: actin binding, p... |
Does Knockout of Tcte2 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Tcte2 | phagocytosis | macrophage | Gene: Tcte2 (t-complex-associated testis expressed 2)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 21646 |
Does Knockout of Hacd1 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Hacd1 | cell cycle progression | breast epithelium | Gene: Hacd1 (3-hydroxyacyl-CoA dehydratase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cementum mineralization, fatty acid biosynthetic process, fatty acid elongation, fatty acid metabolic process, lipid metabolic process, myotube differentiation, positive regulati... |
Does Knockout of Zfp398 in Microglial Cell Line causally result in response to virus? | 0 | 1,438 | Knockout | Zfp398 | response to virus | Microglial Cell Line | Gene: Zfp398 (zinc finger protein 398)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA ... |
Does Knockout of Neurod4 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Neurod4 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Neurod4 (neurogenic differentiation 4)
Type: protein-coding
Summary: This gene belongs to the neurogenic differentiation factor family and encodes a basic helix-loop-helix (bHLH) transcription factor which is expressed in the developing nervous system with high levels of expression in the brain, r... |
Does Knockout of Golga4 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Golga4 | protein/peptide accumulation | Mouse cell | Gene: Golga4 (golgin A4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi vesicle transport, positive regulation of axon extension; MF: GTPase binding, small GTPase binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, m... |
Does Knockout of Pcbp3 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Pcbp3 | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Pcbp3 (poly(rC) binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: C-rich single-stranded DNA binding, DNA binding, RNA binding, mRNA bin... |
Does Knockout of Spice1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Spice1 | cell proliferation | Melanoma Cell Line | Gene: Spice1 (spindle and centriole associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, metaphase chromosome alignment, mitotic spindle assembly, regulation of centriole replication; CC: centriole, centrosome, ciliary basal body, cytoplasm... |
Does Knockout of Smco2 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Smco2 | cell proliferation | Embryonic Stem Cell Line | Gene: Smco2 (single-pass membrane protein with coiled-coil domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q9DA21
Entrez ID: 69371 |
Does Knockout of Ltc4s in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Ltc4s | cell proliferation | Mouse kidney carcinoma cell | Gene: Ltc4s (leukotriene C4 synthase)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme that catalyzes the synthesis of leukotriene C4 by combining leukotriene A4 with reduced glutathione. The encoded protein is found in the outer nuclear membrane and in the peripheral endoplas... |
Does Knockout of Hpse2 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Hpse2 | phagocytosis | macrophage | Gene: Hpse2 (heparanase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extracellular matrix organization, positive regulation of cell population proliferation; MF: heparan sulfate proteoglycan binding, hydrolase activity, acting on glycosyl bonds; CC: extracellular ma... |
Does Knockout of Crebl2 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Crebl2 | protein/peptide accumulation | Embryonic Cell Line | Gene: Crebl2 (cAMP responsive element binding protein-like 2)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including positive regulation of D-glucose import; positive regulation of metabolic process; ... |
Does Knockout of Foxq1 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Foxq1 | phagocytosis | macrophage | Gene: Foxq1 (forkhead box Q1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, hair follicle morphogenesis, morphogenesis of an epithelium, negative regulation of DNA-templated transcription, negative regulation of ... |
Does Knockout of Dpp7 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Dpp7 | cell proliferation | Melanoma Cell Line | Gene: Dpp7 (dipeptidylpeptidase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lysosomal protein catabolic process, protein catabolic process, proteolysis; MF: aminopeptidase activity, dipeptidyl-peptidase activity, hydrolase activity, peptidase activity, serine-type ... |
Does Knockout of Dnajb12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Dnajb12 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Dnajb12 (DnaJ heat shock protein family (Hsp40) member B12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, cellular response to misfolded protein, protein folding, protein-containing complex assembly; MF: Hsp70 protein binding; CC: endoplasmic reticul... |
Does Knockout of Prpf3 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Prpf3 | cell cycle progression | breast epithelium | Gene: Prpf3 (pre-mRNA processing factor 3)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to be located in Cajal body; cytosol; and nuclear speck. Predicted to be part of U2-type precata... |
Does Knockout of Scgb1b3 in Immortal mouse chromaffin cells causally result in cell viability? | 1 | 2,469 | Knockout | Scgb1b3 | cell viability | Immortal mouse chromaffin cells | Gene: Scgb1b3 (secretoglobin, family 1B, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, steroid binding; CC: extracellular region
Pathways:
UniProt: J3QJY4
Entrez ID: 384585 |
Does Knockout of Psg21 in Microglial Cell Line causally result in response to virus? | 0 | 1,438 | Knockout | Psg21 | response to virus | Microglial Cell Line | Gene: Psg21 (pregnancy-specific beta-1-glycoprotein 21)
Type: protein-coding
Summary: Predicted to be involved in T cell activation and immune response. Predicted to be located in apical plasma membrane and cytosol. Predicted to be active in external side of plasma membrane. Is expressed in labyrinthine... |
Does Knockout of Fsd1l in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Fsd1l | cell proliferation | Mouse kidney carcinoma cell | Gene: Fsd1l (fibronectin type III and SPRY domain containing 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BYN5
Entrez ID: 319636 |
Does Knockout of Gcm1 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Gcm1 | phagocytosis | macrophage | Gene: Gcm1 (glial cells missing homolog 1)
Type: protein-coding
Summary: Enables DNA binding activity and zinc ion binding activity. Acts upstream of or within several processes, including astrocyte fate commitment; embryonic placenta development; and positive regulation of syncytium formation by plasma... |
Does Knockout of Vmn1r228 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Vmn1r228 | cell proliferation | Colonic Cancer Cell Line | Gene: Vmn1r228 (vomeronasal 1 receptor 228)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromon... |
Does Knockout of Miga1 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Miga1 | response to chemicals | pro-B-lymphocyte | Gene: Miga1 (mitoguardin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial fusion; MF: protein heterodimerization activity, protein homodimerization activity; CC: membrane, mitochondrial outer membrane, mitochondrion, plasma membrane
Pathways: Glyc... |
Does Knockout of Rom1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Rom1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Rom1 (rod outer segment membrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye photoreceptor cell differentiation, cell adhesion, detection of light stimulus involved in visual perception, photoreceptor cell outer segment organization, p... |
Does Knockout of Rnaseh2b in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Rnaseh2b | protein/peptide distribution | myoblast cell line | Gene: Rnaseh2b (ribonuclease H2, subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, in utero embryonic development, mismatch repair, negative regulation of gene expression, nucleobase-containing compound metabolic process, positive regulatio... |
Does Knockout of Abhd15 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Abhd15 | phagocytosis | macrophage | Gene: Abhd15 (abhydrolase domain containing 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, lipid catabolic process, lipid metabolic process; MF: monoacylglycerol lipase activity, protein binding, short-chain carboxylesterase activity
... |
Does Knockout of Adam6a in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Adam6a | cell proliferation | Colonic Cancer Cell Line | Gene: Adam6a (a disintegrin and metallopeptidase domain 6A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: integrin-mediated signaling pathway, male gonad development, proteolysis; MF: metalloendopeptidase activity, metallopeptidase activity, molecular_function; CC: cell... |
Does Knockout of Gm5283 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Gm5283 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Gm5283 (predicted gene 5283)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Nr4a3 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Nr4a3 | cell proliferation | Melanoma Cell Line | Gene: Nr4a3 (nuclear receptor subfamily 4, group A, member 3)
Type: protein-coding
Summary: This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cel... |
Does Knockout of Tex101 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Tex101 | protein/peptide distribution | Microglial Cell Line | Gene: Tex101 (testis expressed gene 101)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: basophil activation, binding of sperm to zona pellucida, fertilization, flagellated sperm motility, regulation of cytosolic calcium ion concentration, regulation of flagellated sperm ... |
Does Knockout of Epb42 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Epb42 | protein/peptide distribution | myoblast cell line | Gene: Epb42 (erythrocyte membrane protein band 4.2)
Type: protein-coding
Summary: The protein encoded by this gene is the key component of a macromolecular complex involved in the structure of erythrocytes. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: cell morphogenesis, erythrocyte matur... |
Does Knockout of Kifc3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Kifc3 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Kifc3 (kinesin family member C3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, epithelial cell-cell adhesion, microtubule-based movement, microtubule-based process, zonula adherens maintenance; MF: ATP binding, identical protein binding, microt... |
Does Knockout of Lypd4 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Lypd4 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Lypd4 (Ly6/Plaur domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, biological_process, single fertilization, sperm migration through the uterotubal junction; CC: acrosomal vesicle, membrane, plasma membrane, pla... |
Does Knockout of Il1rl1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,174 | Knockout | Il1rl1 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Il1rl1 (interleukin 1 receptor-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inflammatory response, interleukin-33-mediated signaling pathway, macrophage differentiation, negative regulation of T-helper 1 type immune response, negative regulation of canoni... |
Does Knockout of Onecut2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Onecut2 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Onecut2 (one cut domain, family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, cell fate commitment, cilium assembly, endocrine pancreas development, epithelial cell development, liver development, negative regulation o... |
Does Knockout of S100a5 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | S100a5 | response to chemicals | Pancreatic Cancer Cell Line | Gene: S100a5 (S100 calcium binding protein A5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, calcium-dependent protein binding, copper ion binding, metal ion binding, molecular_function, protein homodimerization activity, transition metal ion bindin... |
Does Knockout of Usp10 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Usp10 | protein/peptide distribution | myoblast cell line | Gene: Usp10 (ubiquitin specific peptidase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, autophagy, cellular response to interleukin-1, chromatin remodeling, monoubiquiti... |
Does Knockout of Prss8 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Prss8 | phagocytosis | macrophage | Gene: Prss8 (serine protease 8 (prostasin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of sodium ion transmembrane transport, positive regulation of sodium ion transport, proteolysis, transepithelial transport; MF: hydrolase activity, peptidase ac... |
Does Knockout of B3galt2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | B3galt2 | cell proliferation | Mouse kidney carcinoma cell | Gene: B3galt2 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: galactosylceramide biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, protein O-linked glycosylation, protein... |
Does Knockout of Pop5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Pop5 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Pop5 (processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae))
Type: protein-coding
Summary: Enables ribonuclease P activity. Acts upstream of or within tRNA processing. Part of nucleolar ribonuclease P complex. Is expressed in Meckel's cartilage and skeleton. Orthologous to human POP... |
Does Knockout of Prdm13 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Prdm13 | protein/peptide accumulation | Mouse cell | Gene: Prdm13 (PR domain containing 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GABAergic neuron differentiation, chromatin remodeling, hypothalamus cell differentiation, methylation, negative regulation of transcription by RNA polymerase II, neurogenesis, regulati... |
Does Knockout of Cmbl in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Cmbl | cell proliferation | Colonic Cancer Cell Line | Gene: Cmbl (carboxymethylenebutenolidase homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, molecular_function; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Metabolism, Phase I - Functionalization of compounds
UniProt... |
Does Knockout of Jagn1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Jagn1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Jagn1 (jagunal homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to fungus, endoplasmic reticulum organization, granulocyte colony-stimulating factor signaling pathway, immune system process, insulin metabolic process, insulin secretion, ne... |
Does Knockout of Foxn4 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Foxn4 | phagocytosis | macrophage | Gene: Foxn4 (forkhead box N4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amacrine cell differentiation, atrioventricular canal development, heart looping, nervous system development, neuron fate commitment, positive regulation of transcription by RNA polymerase II, r... |
Does Knockout of Serping1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Serping1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Serping1 (serine (or cysteine) peptidase inhibitor, clade G, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood coagulation, fibrinolysis, hemostasis, negative regulation of complement activation, lectin pathway; MF: peptidase inhibitor activity, serine... |
Does Knockout of Kcp in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Kcp | response to virus | Microglial Cell Line | Gene: Kcp (kielin/chordin-like protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hematopoietic progenitor cell differentiation, positive regulation of BMP signaling pathway; CC: extracellular region, extracellular space
Pathways:
UniProt: Q3U492
... |
Does Knockout of Fbxl12 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Fbxl12 | cell proliferation | Melanoma Cell Line | Gene: Fbxl12 (F-box and leucine-rich repeat protein 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination, ubiquitin-dependent protein catabolic process; CC: cytoplasm, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen proces... |
Does Knockout of Asb15 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Asb15 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Asb15 (ankyrin repeat and SOCS box-containing 15)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; and protein targeting to chloroplast. Predicted to be active in nucleus. Is expressed in genitouri... |
Does Knockout of C1qtnf7 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | C1qtnf7 | cell cycle progression | breast epithelium | Gene: C1qtnf7 (C1q and tumor necrosis factor related protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, protein binding; CC: collagen trimer, extracellular region, extracellular space
Pathways:
UniProt: Q8BVD7
... |
Does Knockout of Rnf149 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | Rnf149 | protein/peptide distribution | myoblast cell line | Gene: Rnf149 (ring finger protein 149)
Type: protein-coding
Summary: Enables ubiquitin protein ligase activity. Acts upstream of or within cellular response to xenobiotic stimulus; negative regulation of MAPK cascade; and regulation of protein stability. Predicted to be located in membrane. Predicted to... |
Does Knockout of Ripor1 in Microglial Cell Line causally result in cell proliferation? | 0 | 1,358 | Knockout | Ripor1 | cell proliferation | Microglial Cell Line | Gene: Ripor1 (RHO family interacting cell polarization regulator 1)
Type: protein-coding
Summary: Predicted to enable 14-3-3 protein binding activity. Predicted to be involved in several processes, including establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange facto... |
Does Knockout of Il16 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,260 | Knockout | Il16 | cell proliferation | Mouse kidney carcinoma cell | Gene: Il16 (interleukin 16)
Type: protein-coding
Summary: Enables cytokine activity. Involved in cytokine-mediated signaling pathway. Acts upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutroph... |
Does Knockout of Bicral in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,308 | Knockout | Bicral | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Bicral (BRD4 interacting chromatin remodeling complex associated protein like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, negative regulation of cell differentiation, positive regulation of DNA-templated transcription, positive regulation ... |
Does Knockout of Psg22 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Psg22 | protein/peptide accumulation | Regulatory T cell | Gene: Psg22 (pregnancy-specific beta-1-glycoprotein 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, female pregnancy, positive regulation of angiogenesis, positive regulation of cytokine production, positive regulation of macrophage cytokine production, ... |
Does Knockout of Cenpq in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Cenpq | phagocytosis | macrophage | Gene: Cenpq (centromere protein Q)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, metaphase chromosome alignment, positive regulation of protein localization to kinetochore; CC: actin cytoskeleton, chromosome, chromosome, centromeric region, inner... |
Does Knockout of Acsf2 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Acsf2 | protein/peptide distribution | myoblast cell line | Gene: Acsf2 (acyl-CoA synthetase family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, lipid metabolic process, small molecule metabolic process; MF: ATP binding, catalytic activity, ligase activity, medium-chain fatty acid-CoA lig... |
Does Knockout of Auh in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Auh | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Auh (AU RNA binding protein/enoyl-coenzyme A hydratase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-leucine catabolic process, branched-chain amino acid catabolic process, fatty acid beta-oxidation; MF: RNA binding, catalytic activity, enoyl-CoA hydratase acti... |
Does Knockout of Zfp473 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Zfp473 | cell proliferation | Melanoma Cell Line | Gene: Zfp473 (zinc finger protein 473)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA 3'-end processing by stem-loop binding and cleavage, negative regulation of DNA-templated transcription, negative regulation of transcription initiation by RNA polymerase II, regul... |
Does Knockout of Il17c in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Il17c | cell proliferation | Mouse kidney carcinoma cell | Gene: Il17c (interleukin 17C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inflammatory response, neutrophil differentiation, positive regulation of cytokine production involved in inflammatory response, signal transduction; MF: cytokine activity; CC: extracellular reg... |
Does Knockout of Ampd2 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Ampd2 | protein/peptide distribution | Microglial Cell Line | Gene: Ampd2 (adenosine monophosphate deaminase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMP metabolic process, ATP metabolic process, GMP salvage, GTP metabolic process, IMP biosynthetic process, IMP salvage, cholesterol homeostasis, cyclic purine nucleotide met... |
Does Knockout of Best3 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Best3 | protein/peptide distribution | Microglial Cell Line | Gene: Best3 (bestrophin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, chloride transport, inorganic anion transport, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative... |
Does Knockout of Nkx2-2 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Nkx2-2 | response to virus | Embryonic Fibroblast Cell Line | Gene: Nkx2-2 (NK2 homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: astrocyte differentiation, cell development, cell differentiation, central nervous system neuron differentiation, digestive tract development, endocrine pancreas development, negative regulation... |
Does Knockout of Tpcn1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,179 | Knockout | Tpcn1 | cell proliferation | Colonic Cancer Cell Line | Gene: Tpcn1 (two pore channel 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, endocytosis involved in viral entry into host cell, monoatomic ion transmembrane transport, monoatomic ... |
Does Knockout of Zfp93 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Zfp93 | protein/peptide accumulation | Embryonic Cell Line | Gene: Zfp93 (zinc finger protein 93)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q61116
Entrez ID: 22755 |
Does Knockout of Cacul1 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Cacul1 | cell proliferation | Regulatory T cell | Gene: Cacul1 (CDK2 associated, cullin domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of protein kinase activity, ubiquitin-dependent protein catabol... |
Does Knockout of Fnbp4 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Fnbp4 | cell proliferation | Regulatory T cell | Gene: Fnbp4 (formin binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6ZQ03
Entrez ID: 55935 |
Does Knockout of Dok5 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Dok5 | response to bacteria | renal medulla cell line | Gene: Dok5 (docking protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, neuron differentiation, positive regulation of MAPK cascade, regulation of neurotrophin TRK receptor signaling pathway
... |
Does Knockout of Ndufa7 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Ndufa7 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Ndufa7 (NADH:ubiquinone oxidoreductase subunit A7)
Type: protein-coding
Summary: This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes th... |
Does Knockout of Txlng in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Txlng | response to bacteria | renal medulla cell line | Gene: Txlng (taxilin gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of bone mineralization, regulation of cell cycle, regulation of cell cycle process; MF: DNA-binding transcription factor binding, protein binding, syntaxin binding; CC: cytoplasm, cytos... |
Does Knockout of Ascc3 in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,525 | Knockout | Ascc3 | response to chemicals | Lymphoma Cell Line | Gene: Ascc3 (activating signal cointegrator 1 complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CAT tailing, DNA alkylation repair, DNA damage response, DNA repair, protein monoubiquitination, protein ufmylation, rescue of stalled ribosome, ribosome disas... |
Does Knockout of Ntng2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Ntng2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Ntng2 (netrin G2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to a subclass of the netrin family called netrin-G proteins. Unlike classic netrins, which act as diffusible chemoattractants, netrin-Gs are glycosylphosphatidylinositol-anchored membrane proteins that interac... |
Does Knockout of Tpra1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Tpra1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Tpra1 (transmembrane protein, adipocyte asscociated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, embryonic cleavage, negative regulation of mitotic cell cycle phase transition; CC: membrane, plasma membrane
... |
Does Knockout of Ccdc171 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Ccdc171 | cell proliferation | Embryonic Stem Cell Line | Gene: Ccdc171 (coiled-coil domain containing 171)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q1U1
Entrez ID: 320226 |
Does Knockout of Sdccag8 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Sdccag8 | cell proliferation | Colonic Cancer Cell Line | Gene: Sdccag8 (serologically defined colon cancer antigen 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, centrosome cycle, establishment of cell polarity, microtubule organizing center organization, neuron migration, regulation of cilium ... |
Does Knockout of Qprt in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Qprt | cell cycle progression | breast epithelium | Gene: Qprt (quinolinate phosphoribosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' NAD+ biosynthetic process from L-tryptophan, NAD+ biosynthetic process, pyridine nucleotide biosynthetic process, quinolinate catabolic process, quinolinate metabo... |
Does Knockout of Trim34b in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Trim34b | cell proliferation | Embryonic Stem Cell Line | Gene: Trim34b (tripartite motif-containing 34B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, innate immune response, protein ubiquitination, regulation of gene expression; MF: identical protein binding, metal ion binding, transferase activity... |
Does Knockout of Lrwd1 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Lrwd1 | protein/peptide accumulation | Microglial Cell Line | Gene: Lrwd1 (leucine-rich repeats and WD repeat domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, chromatin organization, establishment of protein localization to chromatin; MF: chromatin binding, histone H3K27me3 reader activity, methy... |
Does Knockout of Gbgt1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,174 | Knockout | Gbgt1 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Gbgt1 (globoside alpha-1,3-N-acetylgalactosaminyltransferase 1)
Type: protein-coding
Summary: Enables globoside alpha-N-acetylgalactosaminyltransferase activity. Predicted to be involved in globoside metabolic process and lipid glycosylation. Predicted to be located in membrane. Predicted to be ac... |
Does Knockout of Lrrc45 in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Lrrc45 | response to bacteria | macrophage | Gene: Lrrc45 (leucine rich repeat containing 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, plasma membrane
Pathways:
UniProt: Q8CIM1
Entrez ID: 217366 |
Does Knockout of Tpx2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Tpx2 | cell proliferation | Melanoma Cell Line | Gene: Tpx2 (TPX2, microtubule-associated)
Type: protein-coding
Summary: Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in mitotic spindle assembly and regulation of mitotic spindle organization. Located in axon hillock and spindle. Is expressed in ce... |
Does Knockout of Sirt6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Sirt6 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Sirt6 (sirtuin 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, Ras protein signal transduction, base-excision repair, cardiac muscle cell differentiation, cellular response to angiotensin... |
Does Knockout of Lsr in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Lsr | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Lsr (lipolysis stimulated lipoprotein receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial structure maintenance, establishment of blood-brain barrier, establishment of skin barrier, lipoprotein transport, liver development, protein localization to t... |
Does Knockout of Myocd in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Myocd | cell proliferation | Mouse kidney carcinoma cell | Gene: Myocd (myocardin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle cell differentiation, cardiac muscle cell myoblast differentiation, cardiac vascular smooth muscle cell differentiation, cardiac ventricle development, cell growth involved in cardiac m... |
Does Knockout of Trdn in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Trdn | protein/peptide distribution | myoblast cell line | Gene: Trdn (triadin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, endoplasmic reticulum membrane organization, establishment of localization in cell, heart contraction, intracellular calcium ion homeostasis, negative regulation of ... |
Does Knockout of Mtor in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Mtor | cell proliferation | Mouse kidney carcinoma cell | Gene: Mtor (mechanistic target of rapamycin kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' pyrimidine nucleobase biosynthetic process, DNA damage response, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, T-helper 1 cell lineage ... |
Does Knockout of Hoxb3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Hoxb3 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Hoxb3 (homeobox B3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, anterior/posterior pattern specification, cartilage development, definitive hemopoiesis, embryonic skeletal system morphogenesis, face development, glossopharyngeal nerve morphogenesis... |
Does Knockout of Ralgps2 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Ralgps2 | protein/peptide accumulation | Microglial Cell Line | Gene: Ralgps2 (Ral GEF with PH domain and SH3 binding motif 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity; CC: cytoplasm, membrane, plasma membr... |
Does Knockout of Cavin1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Cavin1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Cavin1 (caveolae associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription termination, positive regulation of cell motility, protein secretion, rRNA transcription, termination of RNA polymerase I transcription, transcription initiati... |
Does Knockout of Bmp15 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Bmp15 | phagocytosis | macrophage | Gene: Bmp15 (bone morphogenetic protein 15)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcripti... |
Does Knockout of Slc34a2 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Slc34a2 | cell cycle progression | breast epithelium | Gene: Slc34a2 (solute carrier family 34 (sodium phosphate), member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: in utero embryonic development, intracellular phosphate ion homeostasis, monoatomic ion transport, phosphate ion transport, response to estrogen, sodium i... |
Does Knockout of Tagln2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Tagln2 | cell proliferation | Colonic Cancer Cell Line | Gene: Tagln2 (transgelin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, epithelial cell differentiation
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet c... |
Does Knockout of Trmt112 in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,285 | Knockout | Trmt112 | cell proliferation | Mouse kidney carcinoma cell | Gene: Trmt112 (tRNA methyltransferase 11-2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA, maturation of SSU-rRNA, peptidyl-glutamine methylation, positive regulation of rRNA processing, rRNA (guanine-N7)-methylation, rRNA methylation, tRNA methyl... |
Does Knockout of Epha1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Epha1 | cell proliferation | Melanoma Cell Line | Gene: Epha1 (Eph receptor A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell adhesion, cell surface receptor protein tyrosine kinase signaling pathway, ephrin receptor signaling pathway, negative regulation of cell migration, positive regulation of ang... |
Does Knockout of Samd4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Samd4 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Samd4 (sterile alpha motif domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of translation, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of translation, regulation of mRNA stability, regulation of post... |
Does Knockout of Cdk8 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Cdk8 | protein/peptide accumulation | Microglial Cell Line | Gene: Cdk8 (cyclin dependent kinase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of triglyceride metabolic process, positive regulation of transcription by RNA polymerase II, protein ubiquitination, regulation of cell cycle; MF: ATP binding, RNA ... |
Does Knockout of Npy in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Npy | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Npy (neuropeptide Y)
Type: protein-coding
Summary: This gene encodes a neuropeptide that plays a pivotal role in many physiological functions such as food intake, energy homeostasis, circadian rhythm, and cognition. The encoded protein precursor undergoes proteolytic processing to generate the bio... |
Does Knockout of Col9a2 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Col9a2 | response to virus | Microglial Cell Line | Gene: Col9a2 (collagen, type IX, alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: extracellular matrix structural constituent conferring tensile strength, protein homodimerization activity; CC: collagen trimer, collagen type IX trimer, extracellular matrix, extrac... |
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