prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Idh3g in Microglial Cell Line causally result in phagocytosis? | 0 | 1,587 | Knockout | Idh3g | phagocytosis | Microglial Cell Line | Gene: Idh3g (isocitrate dehydrogenase 3 (NAD+), gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: isocitrate metabolic process, tricarboxylic acid cycle; MF: ATP binding, NAD binding, enzyme activator activity, isocitrate dehydrogenase (NAD+) activity, magnesium ion ... |
Does Knockout of Ptdss1 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,181 | Knockout | Ptdss1 | tumorigenicity | Colonic Cancer Cell Line | Gene: Ptdss1 (phosphatidylserine synthase 1)
Type: protein-coding
Summary: Enables L-serine-phosphatidylcholine phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to be involved in phosphatidylserine biosynthetic process. Located in endopla... |
Does Knockout of Brsk1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Brsk1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Brsk1 (BR serine/threonine kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, G2/M transition of mitotic cell cycle, associative learning, axonogenesis, central nervous system neuron differentiation, centrosome duplication, establishment ... |
Does Knockout of Zfp729b in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Zfp729b | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Zfp729b (zinc finger protein 729b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RN... |
Does Knockout of Cdkl5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Cdkl5 | cell proliferation | Colonic Cancer Cell Line | Gene: Cdkl5 (cyclin dependent kinase like 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: modulation of chemical synaptic transmission, neuron migration, positive regulation of Rac protein signal transduction, positive regulation of axon extension, positive regulation ... |
Does Knockout of Ercc6l2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Ercc6l2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ercc6l2 (excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to reactive oxygen species, double-strand break repair via class... |
Does Knockout of Pgrmc1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Pgrmc1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Pgrmc1 (progesterone receptor membrane component 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: associative learning, axon guidance, heme biosynthetic process, memory, modification of synaptic structure, negative regulation of synapse organization, positive regu... |
Does Knockout of Rsad1 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Rsad1 | response to virus | Microglial Cell Line | Gene: Rsad1 (radical S-adenosyl methionine domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: porphyrin-containing compound biosynthetic process; MF: 4 iron, 4 sulfur cluster binding, catalytic activity, coproporphyrinogen oxidase activity, heme binding,... |
Does Knockout of Mir702 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Mir702 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Mir702 (microRNA 702)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I... |
Does Knockout of Rabep2 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Rabep2 | cell proliferation | Embryonic Stem Cell Line | Gene: Rabep2 (rabaptin, RAB GTPase binding effector protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, endocytosis, protein transport, regulation of cilium assembly, signal transduction; MF: GTPase activator activity, growth factor ac... |
Does Knockout of Pacsin3 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Pacsin3 | protein/peptide accumulation | Regulatory T cell | Gene: Pacsin3 (protein kinase C and casein kinase substrate in neurons 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, endocytosis, negative regulation of calcium ion transport, negative regulation of endocytosis, plasma membrane tubulation, ... |
Does Knockout of Itga3 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Itga3 | protein/peptide accumulation | Melanoma Cell Line | Gene: Itga3 (integrin alpha 3)
Type: protein-coding
Summary: This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded pr... |
Does Knockout of 2900026A02Rik in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | 2900026A02Rik | protein/peptide distribution | myoblast cell line | Gene: 2900026A02Rik (RIKEN cDNA 2900026A02 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cilium, intercellular bridge, microtubule cytoskeleton
Pathways:
UniProt: Q8BRV5
Entrez ID: 243219 |
Does Knockout of Fau in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,262 | Knockout | Fau | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Fau (FAU ubiquitin like and ribosomal protein S30 fusion)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, cytoplasmic translation, defense response to Gram-posit... |
Does Knockout of Pcdha1 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Pcdha1 | cell cycle progression | breast epithelium | Gene: Pcdha1 (protocadherin alpha 1)
Type: protein-coding
Summary: Predicted to be involved in cell adhesion. Located in endoplasmic reticulum and membrane. Is expressed in brain; cerebral cortex; enteric nervous system; and intestine. Orthologous to human PCDHA1 (protocadherin alpha 1). [provided by Al... |
Does Knockout of Fkbp14 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Fkbp14 | cell proliferation | Mouse kidney carcinoma cell | Gene: Fkbp14 (FK506 binding protein 14)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat P3 isomerase activity; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity; and calcium ion binding activity. Predicted to be involved in regulation of transcri... |
Does Knockout of Dhrs13 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Dhrs13 | protein/peptide distribution | myoblast cell line | Gene: Dhrs13 (dehydrogenase/reductase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5SS80
Entrez ID: 70451 |
Does Knockout of Itga8 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,181 | Knockout | Itga8 | tumorigenicity | Colonic Cancer Cell Line | Gene: Itga8 (integrin alpha 8)
Type: protein-coding
Summary: This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked ... |
Does Knockout of Klhl32 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,180 | Knockout | Klhl32 | tumorigenicity | Colonic Cancer Cell Line | Gene: Klhl32 (kelch-like 32)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2AJX0, E9Q7Q2, J3QPI3, J3KML3, A2AJX1
Entrez ID: 212390 |
Does Knockout of Vmn1r200 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Vmn1r200 | protein/peptide distribution | myoblast cell line | Gene: Vmn1r200 (vomeronasal 1 receptor 200)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromon... |
Does Knockout of Mob3b in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Mob3b | protein/peptide distribution | myoblast cell line | Gene: Mob3b (MOB kinase activator 3B)
Type: protein-coding
Summary: Predicted to enable protein kinase activator activity. Predicted to be involved in regulation of hippo signaling and signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebral cortex ventricular layer... |
Does Knockout of Vim in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Vim | cell proliferation | Embryonic Stem Cell Line | Gene: Vim (vimentin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Bergmann glial cell differentiation, astrocyte development, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, cellular response to type II interferon, cytoskeleton organiza... |
Does Knockout of Creb3l2 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Creb3l2 | cell proliferation | Regulatory T cell | Gene: Creb3l2 (cAMP responsive element binding protein 3-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cartilage development, chondrocyte differentiation, endoplasmic reticulum to Golgi vesicle-mediated transport, positive regulation of DNA-templated transcripti... |
Does Knockout of Lsm1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Lsm1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Lsm1 (LSM1 homolog, mRNA degradation associated)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity and pre-mRNA binding activity. Acts upstream of or within negative regulation of neuron differentiation and stem cell population maintenance. Located in P-body. Is expressed in ... |
Does Knockout of Nvl in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Nvl | protein/peptide distribution | myoblast cell line | Gene: Nvl (nuclear VCP-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein binding, positive regulation of telomere maintenance, rRNA processing, regulation of protein localization to nucleolus, ribosomal large subunit biogenesis, ribosome... |
Does Knockout of Tff1 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Tff1 | protein/peptide accumulation | Mouse cell | Gene: Tff1 (trefoil factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, maintenance of gastrointestinal epithelium, negative regulation of cell population proliferation, response to wounding, signal transduction; MF: growth factor activity, pro... |
Does Knockout of Acvr1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Acvr1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Acvr1 (activin A receptor, type 1)
Type: protein-coding
Summary: Enables activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in several processes, including BMP signaling pathway; heart developmen... |
Does Knockout of Ghdc in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Ghdc | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Ghdc (GH3 domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, endoplasmic reticulum, nuclear envelope, nucleus
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q99J23
Entrez ID: 8086... |
Does Knockout of Kmt2d in Melanoma Cell Line causally result in tumorigenicity? | 0 | 2,187 | Knockout | Kmt2d | tumorigenicity | Melanoma Cell Line | Gene: Kmt2d (lysine (K)-specific methyltransferase 2D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, developmental growth, heterochromatin formation, in utero embryonic development, methylation, oocyte growth, oogenesis, positive regulation of ce... |
Does Knockout of Smarcc1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Smarcc1 | protein/peptide distribution | myoblast cell line | Gene: Smarcc1 (SWI/SNF related BAF chromatin remodeling complex subunit C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, chromatin organization, chromatin remodeling, chromosome organization, insulin receptor signaling pathway, negative regu... |
Does Knockout of Abi2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Abi2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Abi2 (abl interactor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, camera-type eye development, cell migration, cell projection morphogenesis, dendrite development, learning or memory, lens fiber cell morphogenesis, mitophagy, n... |
Does Knockout of 1700008O03Rik in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | 1700008O03Rik | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: 1700008O03Rik (RIKEN cDNA 1700008O03 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3Z070
Entrez ID: 69349 |
Does Knockout of Gtf2e2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 163 | Knockout | Gtf2e2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcript... |
Does Knockout of Tsc1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 2,170 | Knockout | Tsc1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Tsc1 (TSC complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import, TORC1 signaling, adaptive immune response, adult locomotory behavior, associative learning, cardiac muscle cell differentiation, cell projection organization, cell-matrix ... |
Does Knockout of Nr4a3 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Nr4a3 | cell proliferation | Colonic Cancer Cell Line | Gene: Nr4a3 (nuclear receptor subfamily 4, group A, member 3)
Type: protein-coding
Summary: This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cel... |
Does Knockout of Nfyc in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Nfyc | protein/peptide accumulation | Microglial Cell Line | Gene: Nfyc (nuclear transcription factor-Y gamma)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding ... |
Does Knockout of Krt78 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Krt78 | response to virus | Embryonic Fibroblast Cell Line | Gene: Krt78 (keratin 78)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermediate filament organization, keratinization; CC: cornified envelope, intermediate filament, keratin filament
Pathways: Developmental Biology, Formation of the cornified envelope, Kera... |
Does Knockout of Gm9887 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 1,266 | Knockout | Gm9887 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Gm9887 (predicted gene 9887)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Nlgn1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Nlgn1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Nlgn1 (neuroligin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMPA glutamate receptor clustering, AMPA selective glutamate receptor signaling pathway, NMDA glutamate receptor clustering, NMDA selective glutamate receptor signaling pathway, calcium-dependent c... |
Does Knockout of Tmem231 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Tmem231 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Tmem231 (transmembrane protein 231)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye development, cell projection organization, cilium assembly, embryonic digit morphogenesis, in utero embryonic development, neuroepithelial cell differentiation, regul... |
Does Knockout of Prkcsh in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Prkcsh | cell proliferation | Melanoma Cell Line | Gene: Prkcsh (protein kinase C substrate 80K-H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-glycan processing, in utero embryonic development, liver development, negative regulation of neuron projection development, nitrogen cycle metabolic process; MF: RNA binding,... |
Does Knockout of Hsd17b12 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Hsd17b12 | protein/peptide distribution | myoblast cell line | Gene: Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen biosynthetic process, extracellular matrix organization, fatty acid biosynthetic process, fatty acid elongation, saturated fatty acid, lipid metabolic proce... |
Does Knockout of Adamts20 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Adamts20 | cell proliferation | Colonic Cancer Cell Line | Gene: Adamts20 (ADAM metallopeptidase with thrombospondin type 1 motif 20)
Type: protein-coding
Summary: This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissu... |
Does Knockout of Ubxn2a in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Ubxn2a | response to virus | Microglial Cell Line | Gene: Ubxn2a (UBX domain protein 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, autophagosome assembly, cellular response to leukemia inhibitory factor, membrane fusion, negative regulation of ERAD pathway, negative regulation of proteolysis, nucl... |
Does Knockout of Ago4 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Ago4 | response to virus | Embryonic Fibroblast Cell Line | Gene: Ago4 (argonaute RISC catalytic subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RISC complex assembly, mRNA catabolic process, male gonad development, male meiotic nuclear division, miRNA metabolic process, miRNA processing, miRNA-mediated gene silencing b... |
Does Knockout of F13b in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | F13b | cell proliferation | Mammary Gland Tumor Cell Line | Gene: F13b (coagulation factor XIII, beta subunit)
Type: protein-coding
Summary: This gene encodes subunit B of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit A to form a heterotetrameric protein that circulates in ... |
Does Knockout of Lrit3 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Lrit3 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Lrit3 (leucine-rich repeat, immunoglobulin-like and transmembrane domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gene expression, intracellular protein localization, regulation of fibroblast growth factor receptor signaling pathway, response to light sti... |
Does Knockout of Sgcd in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Sgcd | cell cycle progression | breast epithelium | Gene: Sgcd (sarcoglycan, delta (dystrophin-associated glycoprotein))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion homeostasis, calcium-mediated signaling, cardiac muscle cell contraction, cardiac muscle cell development, cardiac muscle contraction, cardiac ... |
Does Knockout of Bpifa5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Bpifa5 | cell proliferation | Colonic Cancer Cell Line | Gene: Bpifa5 (BPI fold containing family A, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, immune response in nasopharyngeal-associated lymphoid tissue, inn... |
Does Knockout of Gsdmcl2 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Gsdmcl2 | phagocytosis | macrophage | Gene: Gsdmcl2 (gasdermin C-like 2)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Extl1 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Extl1 | cell viability | Immortal mouse chromaffin cells | Gene: Extl1 (exostosin-like glycosyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heparan sulfate proteoglycan biosynthetic process, protein glycosylation; MF: acetylglucosaminyltransferase activity, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-... |
Does Knockout of Glmn in Melanoma Cell Line causally result in tumorigenicity? | 0 | 617 | Knockout | Glmn | tumorigenicity | Melanoma Cell Line | Gene: Glmn (glomulin, FKBP associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, circulatory system development, epigenetic regulation of gene expression, muscle cell differentiation, negative regulation of T cell pro... |
Does Knockout of Mycbp in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Mycbp | cell proliferation | Embryonic Stem Cell Line | Gene: Mycbp (MYC binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: transcription coactivator activity; CC: cytoplasm, mitochondrion, nucleoplasm, nucleus
... |
Does Knockout of Tnfrsf22 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Tnfrsf22 | cell proliferation | Melanoma Cell Line | Gene: Tnfrsf22 (tumor necrosis factor receptor superfamily, member 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TRAIL-activated apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation... |
Does Knockout of Foxn1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Foxn1 | protein/peptide distribution | myoblast cell line | Gene: Foxn1 (forkhead box N1)
Type: protein-coding
Summary: The protein encoded by this gene is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members... |
Does Knockout of Capza1 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,684 | Knockout | Capza1 | protein/peptide distribution | myoblast cell line | Gene: Capza1 (capping actin protein of muscle Z-line subunit alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament capping, barbed-end actin filament capping, cell junction assembly; MF: actin binding, actin filament bind... |
Does Knockout of Pip5k1a in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Pip5k1a | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Pip5k1a (phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha)
Type: protein-coding
Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Acts upstream of or within fibroblast migration and phosphatidylinositol biosynthetic process. Located in cytosol; nucleus; and ruffle membr... |
Does Knockout of Sult1c2 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Sult1c2 | protein/peptide accumulation | Mouse cell | Gene: Sult1c2 (sulfotransferase family, cytosolic, 1C, member 2)
Type: protein-coding
Summary: Enables aryl sulfotransferase activity. Involved in sulfation. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Is expressed in central nervous system; sensory organ; and skeleton. Ort... |
Does Knockout of Atg5 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,276 | Knockout | Atg5 | cell proliferation | Colonic Cancer Cell Line | Gene: Atg5 (autophagy related 5)
Type: protein-coding
Summary: The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic... |
Does Knockout of Hps4 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Hps4 | cell proliferation | Regulatory T cell | Gene: Hps4 (HPS4, biogenesis of lysosomal organelles complex 3 subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood coagulation, lysosome organization, melanocyte differentiation, melanosome assembly, platelet dense granule organization, protein stabilization,... |
Does Knockout of Pcdhb11 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Pcdhb11 | cell proliferation | Embryonic Stem Cell Line | Gene: Pcdhb11 (protocadherin beta 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways: ... |
Does Knockout of Dnd1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Dnd1 | cell proliferation | Colonic Cancer Cell Line | Gene: Dnd1 (DND microRNA-mediated repression inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, germ cell development, mRNA stabilization, negative regulation of miRNA-mediated gene silencing, spermatogenesis; MF: RNA bindin... |
Does Knockout of Gga1 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Gga1 | response to virus | Neuroblastoma Cell Line | Gene: Gga1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi to plasma membrane transport, intracellular protein localization, intracellular protein tra... |
Does Knockout of Cfl1 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Cfl1 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Cfl1 (cofilin 1, non-muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament depolymerization, actin filament fragmentation, actin filament organization, actin filament severing, cell motility, cell projection organization, cellular response to epider... |
Does Knockout of Pagr1a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Pagr1a | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Pagr1a (PAXIP1 associated glutamate rich protein 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chorion development, positive regulation of cell cycle G1/S phase transition, positive regulation of intracellula... |
Does Knockout of Niban1 in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Niban1 | response to bacteria | macrophage | Gene: Niban1 (niban apoptosis regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of protein phosphorylation, positive regulation of protein phosphorylation, positive regulation of translation, regulation of translation, response to endoplasmi... |
Does Knockout of Ttyh2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Ttyh2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Ttyh2 (tweety family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate transmembrane transport, chloride transmembrane transport, chloride transport, monoatomic ion transmembrane transport, monoatomic ion transport; MF: calcium ion binding, chlor... |
Does Knockout of Lipn in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Lipn | cell proliferation | Mouse kidney carcinoma cell | Gene: Lipn (lipase, family member N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid catabolic process, lipid metabolic process; MF: hydrolase activity, hydrolase activity, acting on ester bonds, lipase activity, sterol ester esterase activity, triacylglycerol lipas... |
Does Knockout of Rab7b in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Rab7b | cell proliferation | Mouse kidney carcinoma cell | Gene: Rab7b (RAB7B, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to type II interferon, endosome to lysosome transport, late endosome to Golgi transport, negative regulation of toll-like receptor 4 signaling pathway, negati... |
Does Knockout of Ap1m1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Ap1m1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ap1m1 (adaptor-related protein complex AP-1, mu subunit 1)
Type: protein-coding
Summary: This gene encodes the mu-1 subunit of the scaffolding adapter protein complex AP-1 and is a member of the mu adaptin family. The AP-1 complex, which consists of 4 subunits (mu-adaptin, beta-prime adaptin, gamm... |
Does Knockout of Zfp568 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Zfp568 | cell cycle progression | breast epithelium | Gene: Zfp568 (zinc finger protein 568)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: convergent extension involved in axis elongation, convergent extension involved in neural plate elongation, embryonic placenta morphogenesis, in utero embryonic development, negative re... |
Does Knockout of Rhd in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Rhd | cell proliferation | Melanoma Cell Line | Gene: Rhd (Rh blood group, D antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ammonium homeostasis, ammonium transmembrane transport, erythrocyte development, multicellular organismal-level iron ion homeostasis; MF: ammonium channel activity; CC: ankyrin-1 complex... |
Does Knockout of Pstk in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Pstk | phagocytosis | macrophage | Gene: Pstk (phosphoseryl-tRNA kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: selenocysteine incorporation, translation; MF: ATP binding, L-seryl-tRNA(Sec) kinase activity, kinase activity, nucleotide binding, tRNA binding, transferase activity; CC: cytosol, mitoc... |
Does Knockout of Tal2 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Tal2 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Tal2 (T cell acute lymphocytic leukemia 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: midbrain development, multicellular organism growth, post-embryonic development, regulation of transcription by RNA polymerase II, thalamus development; MF: DNA binding, DNA-b... |
Does Knockout of Sgca in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Sgca | cell proliferation | Colonic Cancer Cell Line | Gene: Sgca (sarcoglycan, alpha (dystrophin-associated glycoprotein))
Type: protein-coding
Summary: This gene encodes a member of the sarcoglycan alpha/epsilon family of transmembrane proteins. The encoded protein is part of the dystrophin-glycoprotein complex which links the extracellular matrix to the ... |
Does Knockout of Mal2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Mal2 | cell proliferation | Melanoma Cell Line | Gene: Mal2 (mal, T cell differentiation protein 2)
Type: protein-coding
Summary: Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in membrane raft. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 s... |
Does Knockout of Sco1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Sco1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Sco1 (SCO1 cytochrome c oxidase assembly protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: copper ion homeostasis, cyclooxygenase pathway, gene expression, homeostasis of number of cells, immune response, intracellular copper ion homeostasis, intracellular ir... |
Does Knockout of Hgf in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Hgf | response to chemicals | Pancreatic Cancer Cell Line | Gene: Hgf (hepatocyte growth factor)
Type: protein-coding
Summary: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generat... |
Does Knockout of Lrrc28 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Lrrc28 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Lrrc28 (leucine rich repeat containing 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: PML body, cellular_component
Pathways:
UniProt: Q3TX51
Entrez ID: 67867 |
Does Knockout of Foxc1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Foxc1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Foxc1 (forkhead box C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, anatomical structure morphogenesis, angiogenesis, artery morphogenesis, blood vessel development, blood vessel diameter maintenance, blood vessel remodeling, brain devel... |
Does Knockout of Pex19 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Pex19 | cell proliferation | Mouse kidney carcinoma cell | Gene: Pex19 (peroxisomal biogenesis factor 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of protein localization to peroxisome, peroxisome fission, peroxisome membrane biogenesis, peroxisome organization, protein folding, protein import into peroxisome... |
Does Knockout of Rxfp2 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Rxfp2 | phagocytosis | macrophage | Gene: Rxfp2 (relaxin/insulin-like family peptide receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-cou... |
Does Knockout of Tuft1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Tuft1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Tuft1 (tuftelin 1)
Type: protein-coding
Summary: Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin n... |
Does Knockout of Mir6976 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Mir6976 | cell cycle progression | breast epithelium | Gene: Mir6976 (microRNA 6976)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of Gabrb3 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Gabrb3 | protein/peptide accumulation | Embryonic Cell Line | Gene: Gabrb3 (GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cellular response to histamine, cellular response to zinc ion, cerebellum development, chemical synaptic transmission, chloride... |
Does Knockout of Gm15114 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Gm15114 | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Gm15114 (predicted gene 15114)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: B1B0X6
Entrez ID: 100034729 |
Does Knockout of Tcerg1l in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Tcerg1l | phagocytosis | macrophage | Gene: Tcerg1l (transcription elongation regulator 1-like)
Type: protein-coding
Summary: Predicted to enable RNA polymerase binding activity and transcription coregulator activity. Predicted to be active in nucleus. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human TCE... |
Does Knockout of Tmprss2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Tmprss2 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Tmprss2 (transmembrane protease, serine 2)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Involved in proteolysis. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including brain; extraembryonic component; genit... |
Does Knockout of Tmc7 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Tmc7 | protein/peptide accumulation | Microglial Cell Line | Gene: Tmc7 (transmembrane channel-like gene family 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, sensory perception of mechanical stimulus; MF: ion channel inhibitor activity, mechanosensitive monoatomic ion channel activity, p... |
Does Knockout of Adgra1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Adgra1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Adgra1 (adhesion G protein-coupled receptor A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway; MF: G protein-coupled receptor activity, molecular_function, transmembrane signalin... |
Does Knockout of Spice1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | Spice1 | protein/peptide distribution | myoblast cell line | Gene: Spice1 (spindle and centriole associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, metaphase chromosome alignment, mitotic spindle assembly, regulation of centriole replication; CC: centriole, centrosome, ciliary basal body, cytoplasm... |
Does Knockout of Slc45a1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Slc45a1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Slc45a1 (solute carrier family 45, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose transmembrane transport, galactose transmembrane transport, sucrose transport, transmembrane transport; MF: D-glucose:proton symporter activity, galactose:proton s... |
Does Knockout of Mybl1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Mybl1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Mybl1 (myeloblastosis oncogene-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, male meiosis I, mitotic cell cycle, positive regulation of piRNA transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-... |
Does Knockout of Mecom in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 81 | Knockout | Mecom | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Mecom (MDS1 and EVI1 complex locus)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cell differentiation, chromatin remodeling, embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, forebrain development, hematopoietic stem cell prol... |
Does Knockout of Usp45 in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,523 | Knockout | Usp45 | response to chemicals | Lymphoma Cell Line | Gene: Usp45 (ubiquitin specific petidase 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, cell migration, neural retina development, photoreceptor cell maintenance, protein deubiquitination, proteolysis; MF: cysteine-type deubiquitinase activity, cysteine-t... |
Does Knockout of Gria2 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Gria2 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Gria2 (glutamate receptor, ionotropic, AMPA2 (alpha 2))
Type: protein-coding
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of g... |
Does Knockout of Rbm34 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Rbm34 | cell proliferation | Colonic Cancer Cell Line | Gene: Rbm34 (RNA binding motif protein 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: RNA binding, molecular_function, nucleic acid binding; CC: chromoso... |
Does Knockout of Il17a in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Il17a | protein/peptide accumulation | Regulatory T cell | Gene: Il17a (interleukin 17A)
Type: protein-coding
Summary: This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain ce... |
Does Knockout of Mex3d in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Mex3d | protein/peptide accumulation | Melanoma Cell Line | Gene: Mex3d (mex3 RNA binding family member D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA destabilization, mRNA catabolic process, mRNA destabilization; MF: RNA binding, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, metal ion binding, nucleic acid bind... |
Does Knockout of Btbd35f14 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Btbd35f14 | cell cycle progression | breast epithelium | Gene: Btbd35f14 (BTB domain containing 35, family member 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, germ cell development
Pathways:
UniProt: Q1LZI5
Entrez ID: 100040732 |
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