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Does Knockout of Zhx3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
83
Knockout
Zhx3
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Zhx3 (zinc fingers and homeoboxes 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of osteoblast differentiatio...
Does Knockout of Oosp1 in Melanoma Cell Line causally result in cell proliferation?
0
2,488
Knockout
Oosp1
cell proliferation
Melanoma Cell Line
Gene: Oosp1 (oocyte secreted protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: blastocyst development, in utero embryonic development; CC: extracellular region Pathways: UniProt: Q925U0 Entrez ID: 170834
Does Knockout of Fbxw22 in myoblast cell line causally result in protein/peptide distribution?
1
1,679
Knockout
Fbxw22
protein/peptide distribution
myoblast cell line
Gene: Fbxw22 (F-box and WD-40 domain protein 22) Type: protein-coding Summary: Predicted to be active in cytoplasm. Orthologous to human FBXW12 (F-box and WD repeat domain containing 12). [provided by Alliance of Genome Resources, Jul 2025] Gene Ontology: CC: cellular_component, cytoplasm ...
Does Knockout of Rab8a in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,263
Knockout
Rab8a
cell proliferation
Colonic Cancer Cell Line
Gene: Rab8a (RAB8A, member RAS oncogene family) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Golgi organization, Golgi vesicle fusion to target membrane, autophagy, axonogenesis, cell projection organization, cellular response to insulin stimulus, cilium assembly, endo...
Does Knockout of Cenpc1 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,275
Knockout
Cenpc1
cell proliferation
Colonic Cancer Cell Line
Gene: Cenpc1 (centromere protein C1) Type: protein-coding Summary: This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA...
Does Knockout of Ubr5 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,174
Knockout
Ubr5
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Ubr5 (ubiquitin protein ligase E3 component n-recognin 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, cytoplasm protein quality control, cytoplasm protein quality control by the ubiquiti...
Does Knockout of Tigar in Melanoma Cell Line causally result in cell proliferation?
0
2,492
Knockout
Tigar
cell proliferation
Melanoma Cell Line
Gene: Tigar (Trp53 induced glycolysis regulatory phosphatase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, apoptotic process, autophagy, cellular response to cobalt ion, cellular response to hypoxia, fructose 2,6-bisphosphate metabolic process, int...
Does Knockout of Hook1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
161
Knockout
Hook1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Hook1 (hook microtubule tethering protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Golgi organization, cell differentiation, cytoplasmic microtubule organization, cytoskeleton-dependent intracellular transport, early endosome to late endosome transport, en...
Does Knockout of Wfdc3 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
0
1,077
Knockout
Wfdc3
protein/peptide accumulation
Mouse Embryonic Stem Cell
Gene: Wfdc3 (WAP four-disulfide core domain 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: antibacterial humoral response, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular s...
Does Knockout of Tbx22 in Microglial Cell Line causally result in response to virus?
0
2,429
Knockout
Tbx22
response to virus
Microglial Cell Line
Gene: Tbx22 (T-box 22) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell fate specification, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of...
Does Knockout of Slc18a3 in Colonic Cancer Cell Line causally result in tumorigenicity?
0
2,181
Knockout
Slc18a3
tumorigenicity
Colonic Cancer Cell Line
Gene: Slc18a3 (solute carrier family 18 (vesicular monoamine), member 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: acetylcholine transport, acetylcholine uptake, chemical synaptic transmission, monoamine transport, neurotransmitter loading into synaptic vesicle, neu...
Does Knockout of Exoc5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,261
Knockout
Exoc5
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Exoc5 (exocyst complex component 5) Type: protein-coding Summary: Predicted to enable small GTPase binding activity. Involved in protein localization to plasma membrane. Acts upstream of or within with a positive effect on establishment of planar polarity. Acts upstream of or within with a negativ...
Does Knockout of Ly6c1 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,398
Knockout
Ly6c1
protein/peptide accumulation
Microglial Cell Line
Gene: Ly6c1 (lymphocyte antigen 6 family member C1) Type: protein-coding Summary: Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Located in external side of plasma membrane. ...
Does Knockout of Gm5111 in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Gm5111
cell cycle progression
breast epithelium
Gene: Gm5111 (predicted gene 5111) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q3SXC8, Q8C9M4 Entrez ID: 330305
Does Knockout of Slk in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,290
Knockout
Slk
cell proliferation
Mouse kidney carcinoma cell
Gene: Slk (STE20-like kinase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic process, cellular response to type II interferon, cytoplasmic microtubule organization, intracellular signal transduction, positive regulation of apoptotic process, protein autophospho...
Does Knockout of Gm44140 in Microglial Cell Line causally result in protein/peptide distribution?
0
1,585
Knockout
Gm44140
protein/peptide distribution
Microglial Cell Line
Gene: Gm44140 (predicted gene, 44140) Type: ncRNA Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID: 108169174
Does Knockout of Sphkap in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Sphkap
protein/peptide accumulation
Embryonic Cell Line
Gene: Sphkap (SPHK1 interactor, AKAP domain containing) Type: protein-coding Summary: No summary available. Gene Ontology: MF: protein kinase A binding; CC: Z disc, cytoplasm, mitochondrion Pathways: UniProt: A0A0R4J1Y6, E9PUC4 Entrez ID: 77629
Does Knockout of Usp2 in pro-B-lymphocyte causally result in response to chemicals?
0
1,720
Knockout
Usp2
response to chemicals
pro-B-lymphocyte
Gene: Usp2 (ubiquitin specific peptidase 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: circadian behavior, circadian regulation of gene expression, entrainment of circadian clock by photoperiod, locomotor rhythm, muscle organ development, negative regulation of calci...
Does Knockout of Rps19 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,286
Knockout
Rps19
cell proliferation
Mouse kidney carcinoma cell
Gene: Rps19 (ribosomal protein S19) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Notch signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, cytoplasmic translation, defense response to Gram-negative bacterium, erythrocyte differen...
Does Knockout of Pwwp2b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,278
Knockout
Pwwp2b
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Pwwp2b (PWWP domain containing 2B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: chromatin remodeling, positive regulation of transcription elongation by RNA polymerase II, regulation of cold-induced thermogenesis; MF: NuRD complex binding, protein binding; CC: nu...
Does Knockout of Shd in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,259
Knockout
Shd
cell proliferation
Mouse kidney carcinoma cell
Gene: Shd (src homology 2 domain-containing transforming protein D) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: O88834 Entrez ID: 20420
Does Knockout of Cacng5 in Colonic Cancer Cell Line causally result in cell proliferation?
0
2,179
Knockout
Cacng5
cell proliferation
Colonic Cancer Cell Line
Gene: Cacng5 (calcium channel, voltage-dependent, gamma subunit 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, positive regulation of synaptic transmission, glutamatergic, postsynaptic neurotransmitter recept...
Does Knockout of Plekha2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Plekha2
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Plekha2 (pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: positive regulation of cell-matrix adhesion; MF: PDZ domain binding, fibronectin binding, laminin binding, lipid bi...
Does Knockout of Actn2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,290
Knockout
Actn2
cell proliferation
Mouse kidney carcinoma cell
Gene: Actn2 (actinin alpha 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: actin cytoskeleton organization, actin filament uncapping, cardiac muscle cell development, focal adhesion assembly, microspike assembly, muscle cell development, muscle contraction, negative re...
Does Knockout of Scgb1b24 in Microglial Cell Line causally result in protein/peptide distribution?
0
1,585
Knockout
Scgb1b24
protein/peptide distribution
Microglial Cell Line
Gene: Scgb1b24 (secretoglobin, family 1B, member 24) Type: protein-coding Summary: No summary available. Gene Ontology: MF: molecular_function, steroid binding; CC: extracellular region Pathways: UniProt: B1B0N6 Entrez ID: 100043860
Does Knockout of Csnk1e in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,267
Knockout
Csnk1e
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Csnk1e (casein kinase 1, epsilon) Type: protein-coding Summary: The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replicatio...
Does Knockout of Cd83 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,481
Knockout
Cd83
protein/peptide accumulation
Regulatory T cell
Gene: Cd83 (CD83 antigen) Type: protein-coding Summary: No summary available. Gene Ontology: BP: immune system process, negative regulation of interleukin-4 production, positive regulation of CD4-positive, alpha-beta T cell differentiation, positive regulation of interleukin-10 production, posi...
Does Knockout of Kctd16 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
83
Knockout
Kctd16
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Kctd16 (potassium channel tetramerisation domain containing 16) Type: protein-coding Summary: Predicted to enable G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and G protein-coupled neurotransmitter receptor activity involved in regu...
Does Knockout of Amigo3 in Mouse cell causally result in protein/peptide accumulation?
0
1,047
Knockout
Amigo3
protein/peptide accumulation
Mouse cell
Gene: Amigo3 (adhesion molecule with Ig like domain 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: brain development, cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, negative regulation of neuron projection development, nerv...
Does Knockout of Zfp474 in Melanoma Cell Line causally result in cell proliferation?
0
2,488
Knockout
Zfp474
cell proliferation
Melanoma Cell Line
Gene: Zfp474 (zinc finger protein 474) Type: protein-coding Summary: No summary available. Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding Pathways: UniProt: Q6V5K9 Entrez ID: 66758
Does Knockout of Gsta3 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
0
1,077
Knockout
Gsta3
protein/peptide accumulation
Mouse Embryonic Stem Cell
Gene: Gsta3 (glutathione S-transferase, alpha 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: aflatoxin catabolic process, glutathione metabolic process, lipid metabolic process, ureteric bud development, xenobiotic metabolic process; MF: dinitrosyl-iron complex bindin...
Does Knockout of Dcdc2b in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,288
Knockout
Dcdc2b
cell proliferation
Mouse kidney carcinoma cell
Gene: Dcdc2b (doublecortin domain containing 2b) Type: protein-coding Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. ...
Does Knockout of Barx1 in Embryonic Stem Cell Line causally result in cell proliferation?
0
578
Knockout
Barx1
cell proliferation
Embryonic Stem Cell Line
Gene: Barx1 (BarH-like homeobox 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: animal organ development, anterior/posterior pattern specification, cell-cell signaling, digestive system development, endothelial cell differentiation, negative regulation of Wnt signaling...
Does Knockout of Cep135 in myoblast cell line causally result in protein/peptide distribution?
0
1,680
Knockout
Cep135
protein/peptide distribution
myoblast cell line
Gene: Cep135 (centrosomal protein 135) Type: protein-coding Summary: No summary available. Gene Ontology: BP: centriole replication, centriole-centriole cohesion, positive regulation of establishment of protein localization, positive regulation of non-motile cilium assembly; MF: identical prote...
Does Knockout of Fam169a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,266
Knockout
Fam169a
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Fam169a (family with sequence similarity 169, member A) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cellular_component, membrane, nuclear envelope, nuclear inner membrane, nucleus Pathways: RHO GTPase cycle, RHOF GTPase cycle, Signal Transduction, Signa...
Does Knockout of Papss1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
1,565
Knockout
Papss1
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Papss1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) Type: protein-coding Summary: Enables adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process. Predicted to be part of sulfate adenylyltransferas...
Does Knockout of Eif2s1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
Eif2s1
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha) Type: protein-coding Summary: No summary available. Gene Ontology: BP: HRI-mediated signaling, PERK-mediated unfolded protein response, cellular response to UV, cellular response to amino acid starvation, cellular respon...
Does Knockout of Arhgap30 in Melanoma Cell Line causally result in cell proliferation?
0
1,281
Knockout
Arhgap30
cell proliferation
Melanoma Cell Line
Gene: Arhgap30 (Rho GTPase activating protein 30) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of Rho protein signal transduction, signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity Pathways: CDC42...
Does Knockout of Tbc1d9 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,175
Knockout
Tbc1d9
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Tbc1d9 (TBC1 domain family, member 9) Type: protein-coding Summary: No summary available. Gene Ontology: MF: GTPase activator activity, calcium ion binding Pathways: UniProt: Q3UYK3 Entrez ID: 71310
Does Knockout of Ripply3 in myoblast cell line causally result in protein/peptide distribution?
0
1,682
Knockout
Ripply3
protein/peptide distribution
myoblast cell line
Gene: Ripply3 (ripply transcriptional repressor 3) Type: protein-coding Summary: Involved in heart development; negative regulation of transcription by RNA polymerase II; and pharyngeal system development. Acts upstream of or within negative regulation of cell population proliferation. Predicted to be a...
Does Knockout of Slc4a11 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,279
Knockout
Slc4a11
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Slc4a11 (solute carrier family 4, sodium bicarbonate transporter-like, member 11) Type: protein-coding Summary: No summary available. Gene Ontology: BP: bicarbonate transport, borate transmembrane transport, borate transport, cellular hypotonic response, cellular response to oxidative str...
Does Knockout of Ypel4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,279
Knockout
Ypel4
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Ypel4 (yippee like 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of erythrocyte clearance, negative regulation of erythrocyte differentiation, protein localization to plasma membrane, regulation of cell shape; MF: metal ion binding, protein ...
Does Knockout of Snx4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
2,170
Knockout
Snx4
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Snx4 (sorting nexin 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: endocytic recycling, positive regulation of autophagosome assembly, positive regulation of histamine secretion by mast cell, protein transport; MF: epidermal growth factor receptor binding, insul...
Does Knockout of Btk in macrophage causally result in phagocytosis?
0
1,890
Knockout
Btk
phagocytosis
macrophage
Gene: Btk (Bruton agammaglobulinemia tyrosine kinase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: B cell activation, B cell affinity maturation, B cell receptor signaling pathway, T cell receptor signaling pathway, adaptive immune response, apoptotic process, cGAS/STI...
Does Knockout of Zp1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
0
1,077
Knockout
Zp1
protein/peptide accumulation
Mouse Embryonic Stem Cell
Gene: Zp1 (zona pellucida glycoprotein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: binding of sperm to zona pellucida, prevention of polyspermy, single fertilization; MF: acrosin binding, structural constituent of egg coat; CC: egg coat, extracellular matrix, extra...
Does Knockout of Prr5l in pro-B-lymphocyte causally result in response to chemicals?
0
1,720
Knockout
Prr5l
response to chemicals
pro-B-lymphocyte
Gene: Prr5l (proline rich 5 like) Type: protein-coding Summary: No summary available. Gene Ontology: BP: TORC2 signaling, cellular response to oxidative stress, negative regulation of protein phosphorylation, negative regulation of signal transduction, positive regulation of intracellular prote...
Does Knockout of Clcn4 in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Clcn4
cell cycle progression
breast epithelium
Gene: Clcn4 (chloride channel, voltage-sensitive 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: chloride transmembrane transport, chloride transport, monoatomic ion transport, non-motile cilium assembly, transmembrane transport; MF: ATP binding, antiporter activity, c...
Does Knockout of Cfap73 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Cfap73
protein/peptide accumulation
Embryonic Cell Line
Gene: Cfap73 (cilia and flagella associated protein 73) Type: protein-coding Summary: No summary available. Gene Ontology: BP: biological_process, cilium movement, inner dynein arm assembly; MF: dynein complex binding, molecular_function; CC: axonemal doublet microtubule, cell projection, cellu...
Does Knockout of Arhgef12 in Melanoma Cell Line causally result in cell proliferation?
0
1,838
Knockout
Arhgef12
cell proliferation
Melanoma Cell Line
Gene: Arhgef12 (Rho guanine nucleotide exchange factor 12) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho protein signal transduction, Rho-activating G protein-coupled receptor signaling pathway, intracellular signal tran...
Does Knockout of Atp13a1 in Colonic Cancer Cell Line causally result in cell proliferation?
0
2,176
Knockout
Atp13a1
cell proliferation
Colonic Cancer Cell Line
Gene: Atp13a1 (ATPase type 13A1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: extraction of mislocalized protein from ER membrane, intracellular calcium ion homeostasis, monoatomic cation transmembrane transport, protein transport, transmembrane transport; MF: ATP bind...
Does Knockout of Gosr2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Gosr2
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Gosr2 (golgi SNAP receptor complex member 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: intra-Golgi vesicle-mediated transport, protein transport, vesicle fusion, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding; CC: ER to Golgi transport v...
Does Knockout of Sgpp2 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,398
Knockout
Sgpp2
protein/peptide accumulation
Microglial Cell Line
Gene: Sgpp2 (sphingosine-1-phosphate phosphatase 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: lipid metabolic process, phospholipid dephosphorylation, regulation of type B pancreatic cell proliferation, sphingosine metabolic process; MF: dihydrosphingosine-1-phospha...
Does Knockout of Yme1l1 in breast epithelium causally result in cell cycle progression?
0
1,470
Knockout
Yme1l1
cell cycle progression
breast epithelium
Gene: Yme1l1 (YME1-like 1 (S. cerevisiae)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell population proliferation, cellular response to starvation, mitochondrial protein catabolic process, mitochondrial protein processing, mitochondrion organization, negative regul...
Does Knockout of Ptms in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,152
Knockout
Ptms
protein/peptide accumulation
Embryonic Cell Line
Gene: Ptms (parathymosin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: immune system process, negative regulation of apoptotic process, positive regulation of transcription by RNA polymerase II; MF: histone binding, zinc ion binding Pathways: UniProt...
Does Knockout of Dsc1 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Dsc1
protein/peptide accumulation
Embryonic Cell Line
Gene: Dsc1 (desmocollin 1) Type: protein-coding Summary: This gene encodes a member of the cadherin family of proteins that mediates adhesion in desmosomes. The encoded preproprotein undergoes proteolytic processing to generate the mature, functional protein. Mice lacking the encoded protein exhibit epi...
Does Knockout of Sfswap in Pancreatic Cancer Cell Line causally result in response to chemicals?
0
2,359
Knockout
Sfswap
response to chemicals
Pancreatic Cancer Cell Line
Gene: Sfswap (splicing factor SWAP) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA processing, RNA splicing, alternative mRNA splicing, via spliceosome, mRNA 5'-splice site recognition, mRNA processing, negative regulation of mRNA splicing, via spliceosome; MF: RNA b...
Does Knockout of Pon1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,175
Knockout
Pon1
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Pon1 (paraoxonase 1) Type: protein-coding Summary: Enables arylesterase activity. Acts upstream of or within cholesterol metabolic process and response to toxic substance. Predicted to be part of spherical high-density lipoprotein particle. Predicted to be active in extracellular space. Is express...
Does Knockout of Mbp in Microglial Cell Line causally result in response to virus?
0
1,439
Knockout
Mbp
response to virus
Microglial Cell Line
Gene: Mbp (myelin basic protein) Type: protein-coding Summary: The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. ...
Does Knockout of Zfp839 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
Zfp839
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Zfp839 (zinc finger protein 839) Type: protein-coding Summary: No summary available. Gene Ontology: MF: molecular_function, zinc ion binding Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription UniProt: Q9CSB3, E9PUU5,...
Does Knockout of Pomt1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,266
Knockout
Pomt1
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Pomt1 (protein-O-mannosyltransferase 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: extracellular matrix organization, protein O-linked glycosylation, protein O-linked glycosylation via mannose, protein glycosylation; MF: dolichyl-phosphate-mannose-protein manno...
Does Knockout of Il15 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,280
Knockout
Il15
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Il15 (interleukin 15) Type: protein-coding Summary: This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing t...
Does Knockout of Evx2 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Evx2
phagocytosis
macrophage
Gene: Evx2 (even-skipped homeobox 2) Type: protein-coding Summary: This gene is located at the 5' end of the Hoxd gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-ru...
Does Knockout of Susd2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
84
Knockout
Susd2
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Susd2 (sushi domain containing 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of cell cycle G1/S phase transition, negative regulation of cell division; CC: extracellular space, membrane, plasma membrane Pathways: UniProt: ...
Does Knockout of Slco1c1 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Slco1c1
phagocytosis
macrophage
Gene: Slco1c1 (solute carrier organic anion transporter family, member 1c1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: bile acid and bile salt transport, lipid transport, monoatomic ion transport, positive regulation of thyroid hormone generation, sodium-independent ...
Does Knockout of Rprm in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
1,130
Knockout
Rprm
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Rprm (reprimo, TP53 dependent G2 arrest mediator candidate) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of cell cycle, regulation of mitotic cell cycle; CC: cytoplasm, membrane Pathways: p53 signaling pathway - Mus musculus (mouse) U...
Does Knockout of Gzmg in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,290
Knockout
Gzmg
cell proliferation
Mouse kidney carcinoma cell
Gene: Gzmg (granzyme G) Type: protein-coding Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, inc...
Does Knockout of Daam1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,274
Knockout
Daam1
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Daam1 (dishevelled associated activator of morphogenesis 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Wnt signaling pathway, actin cytoskeleton organization, presynaptic actin cytoskeleton organization; MF: actin binding, identical protein binding, protein bin...
Does Knockout of Klra4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
1,565
Knockout
Klra4
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Klra4 (killer cell lectin-like receptor, subfamily A, member 4) Type: protein-coding Summary: Predicted to enable signaling receptor activity. Predicted to be involved in cell adhesion. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] Gene ...
Does Knockout of Ddx47 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
1
2,411
Knockout
Ddx47
cell proliferation
Cytotoxic T-lymphocyte (CD8+ T cells)
Gene: Ddx47 (DEAD box helicase 47) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA splicing, apoptotic process, extrinsic apoptotic signaling pathway via death domain receptors, mRNA processing, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis act...
Does Knockout of Pxdn in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,265
Knockout
Pxdn
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Pxdn (peroxidasin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: angiogenesis, basement membrane assembly, basement membrane organization, cell adhesion, cellular oxidant detoxification, collagen fibril organization, extracellular matrix organization, eye developm...
Does Knockout of Fto in Lymphoma Cell Line causally result in response to chemicals?
0
1,545
Knockout
Fto
response to chemicals
Lymphoma Cell Line
Gene: Fto (FTO alpha-ketoglutarate dependent dioxygenase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA alkylation repair, RNA repair, adipose tissue development, mRNA destabilization, negative regulation of eating behavior, osteoblast differentiation, positive regu...
Does Knockout of Lhb in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,273
Knockout
Lhb
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Lhb (luteinizing hormone beta) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, luteinizing hormone signaling pathway involved in ovarian follicle development, ovarian follicle development; MF: hormone activity; CC: cytop...
Does Knockout of Cul2 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,152
Knockout
Cul2
protein/peptide accumulation
Embryonic Cell Line
Gene: Cul2 (cullin 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, protein catabolic process, protein ubiquitination, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein cat...
Does Knockout of Ccdc27 in Mouse cell causally result in protein/peptide accumulation?
0
1,047
Knockout
Ccdc27
protein/peptide accumulation
Mouse cell
Gene: Ccdc27 (coiled-coil domain containing 27) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q3V036 Entrez ID: 381580
Does Knockout of Dscam in Microglial Cell Line causally result in response to virus?
0
2,429
Knockout
Dscam
response to virus
Microglial Cell Line
Gene: Dscam (DS cell adhesion molecule) Type: protein-coding Summary: No summary available. Gene Ontology: BP: axon guidance, camera-type eye photoreceptor cell differentiation, cell adhesion, central nervous system development, dendrite morphogenesis, dendrite self-avoidance, dendritic spine d...
Does Knockout of Recql in Microglial Cell Line causally result in response to virus?
0
1,439
Knockout
Recql
response to virus
Microglial Cell Line
Gene: Recql (RecQ protein-like) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA recombination, DNA repair, DNA replication, double-strand break repair via homologous recombination, replication fork processing; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolys...
Does Knockout of Ranbp17 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
167
Knockout
Ranbp17
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Ranbp17 (RAN binding protein 17) Type: protein-coding Summary: No summary available. Gene Ontology: BP: intracellular protein transport, mRNA transport, nuclear transport, nucleocytoplasmic transport, protein export from nucleus, protein transport; MF: nuclear export signal receptor activ...
Does Knockout of Wee2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,285
Knockout
Wee2
cell proliferation
Mouse kidney carcinoma cell
Gene: Wee2 (WEE1 homolog 2 (S. pombe)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: female meiotic nuclear division, female pronucleus assembly, meiotic cell cycle, mitotic cell cycle, negative regulation of cyclin-dependent protein serine/threonine kinase activity, ne...
Does Knockout of Klhl33 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,280
Knockout
Klhl33
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Klhl33 (kelch-like 33) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: G3UW92, A0A2I3BRZ3, B7ZMY3 Entrez ID: 546611
Does Knockout of Chfr in breast epithelium causally result in cell cycle progression?
0
1,469
Knockout
Chfr
cell cycle progression
breast epithelium
Gene: Chfr (checkpoint with forkhead and ring finger domains) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell division, meiotic spindle checkpoint signaling, mitotic G2/M transition checkpoint, mitotic cell cycle, positive regulation of proteasomal ubiquitin-dependen...
Does Knockout of Clhc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
82
Knockout
Clhc1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Clhc1 (clathrin heavy chain linker domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q5M6W3 Entrez ID: 73324
Does Knockout of Zcwpw1 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,264
Knockout
Zcwpw1
cell proliferation
Colonic Cancer Cell Line
Gene: Zcwpw1 (zinc finger, CW type with PWWP domain 1) Type: protein-coding Summary: Enables histone H3K4me3 reader activity and methylated histone binding activity. Involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Acts upstream of or within homologous chromosome...
Does Knockout of Pamr1 in Regulatory T cell causally result in cell proliferation?
0
1,484
Knockout
Pamr1
cell proliferation
Regulatory T cell
Gene: Pamr1 (peptidase domain containing associated with muscle regeneration 1) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q8BU25 Entrez ID: 210622
Does Knockout of Aicda in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,280
Knockout
Aicda
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Aicda (activation-induced cytidine deaminase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA cytosine deamination, cellular response to lipopolysaccharide, cytidine to uridine editing, defense response to bacterium, defense response to virus, isotype switching,...
Does Knockout of Zfp747 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,276
Knockout
Zfp747
cell proliferation
Colonic Cancer Cell Line
Gene: Zfp747 (zinc finger protein 747) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular response to glucocorticoid stimulus, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription fac...
Does Knockout of Idh3b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,273
Knockout
Idh3b
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Idh3b (isocitrate dehydrogenase 3 (NAD+) beta) Type: protein-coding Summary: No summary available. Gene Ontology: BP: isocitrate metabolic process, tricarboxylic acid cycle; MF: NAD binding, magnesium ion binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP a...
Does Knockout of 4933427D14Rik in Microglial Cell Line causally result in protein/peptide distribution?
0
1,585
Knockout
4933427D14Rik
protein/peptide distribution
Microglial Cell Line
Gene: 4933427D14Rik (RIKEN cDNA 4933427D14 gene) Type: protein-coding Summary: No summary available. Gene Ontology: BP: centriole replication, cilium assembly, cytosolic ciliogenesis, protein localization to centrosome; CC: centriolar satellite, centrosome, ciliary basal body, cilium, cytoplasm...
Does Knockout of Acr in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,271
Knockout
Acr
cell proliferation
Mouse kidney carcinoma cell
Gene: Acr (acrosin prepropeptide) Type: protein-coding Summary: No summary available. Gene Ontology: BP: acrosome matrix dispersal, acrosome reaction, activation of adenylate cyclase activity, binding of sperm to zona pellucida, penetration of zona pellucida, protein catabolic process, proteoly...
Does Knockout of Gdi2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
81
Knockout
Gdi2
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Gdi2 (GDP dissociation inhibitor 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of cilium assembly, negative regulation of protein localization to cilium, protein transport, small GTPase-mediated signal transduction, vesicle-mediated transpor...
Does Knockout of Sh3tc1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,279
Knockout
Sh3tc1
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Sh3tc1 (SH3 domain and tetratricopeptide repeats 1) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q3TXV8, G3X9F6, Q3UDI4, F6QD49, F6UWL1, F6U4F1 Entrez ID: 231147
Does Knockout of Cep250 in Embryonic Fibroblast Cell Line causally result in response to virus?
0
1,133
Knockout
Cep250
response to virus
Embryonic Fibroblast Cell Line
Gene: Cep250 (centrosomal protein 250) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell projection organization, centriole-centriole cohesion, cilium assembly, detection of light stimulus involved in visual perception, intracellular protein localization, mitotic cell ...
Does Knockout of P3h4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
P3h4
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: P3h4 (prolyl 3-hydroxylase family member 4 (non-enzymatic)) Type: protein-coding Summary: Predicted to contribute to collagen binding activity. Involved in several processes, including collagen biosynthetic process; collagen fibril organization; and peptidyl-lysine hydroxylation. Part of catalytic...
Does Knockout of Psmd8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
Psmd8
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Psmd8 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 8) Type: protein-coding Summary: No summary available. Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis; CC: nucleus, proteasome accessory complex, proteasome complex, proteaso...
Does Knockout of Mib1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,175
Knockout
Mib1
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Mib1 (MIB E3 ubiquitin protein ligase 1) Type: protein-coding Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including Notch signaling pathway; chordate embryonic development; and circulatory system development. Located in cytoplasmic ...
Does Knockout of Fbxo25 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,287
Knockout
Fbxo25
cell proliferation
Mouse kidney carcinoma cell
Gene: Fbxo25 (F-box protein 25) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein ubiquitination; MF: actin binding, protein binding; CC: SCF ubiquitin ligase complex, cytoplasm, nucleus Pathways: FoxO signaling pathway - Mus musculus (mouse) UniPr...
Does Knockout of Tmem165 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,261
Knockout
Tmem165
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Tmem165 (transmembrane protein 165) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Golgi calcium ion homeostasis, Golgi calcium ion transport, calcium ion transmembrane transport, calcium ion transport, intracellular calcium ion homeostasis, manganese ion transmemb...
Does Knockout of Mt3 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,482
Knockout
Mt3
protein/peptide accumulation
Regulatory T cell
Gene: Mt3 (metallothionein 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: activation of protein kinase B activity, cellular detoxification, cellular response to cadmium ion, cellular response to copper ion, cellular response to hypoxia, cellular response to oxidative ...
Does Knockout of Bicd2 in Melanoma Cell Line causally result in cell proliferation?
0
1,281
Knockout
Bicd2
cell proliferation
Melanoma Cell Line
Gene: Bicd2 (BICD cargo adaptor 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: centrosome localization, mRNA transport, microtubule anchoring at microtubule organizing center, microtubule-based movement, minus-end-directed organelle transport along microtubule, protei...
Does Knockout of Furin in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
688
Knockout
Furin
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Furin (furin, paired basic amino acid cleaving enzyme) Type: protein-coding Summary: This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation d...
Does Knockout of Cyp3a13 in Colonic Cancer Cell Line causally result in tumorigenicity?
0
2,178
Knockout
Cyp3a13
tumorigenicity
Colonic Cancer Cell Line
Gene: Cyp3a13 (cytochrome P450, family 3, subfamily a, polypeptide 13) Type: protein-coding Summary: No summary available. Gene Ontology: BP: oxidative demethylation, positive regulation of gene expression, steroid metabolic process, xenobiotic transport; MF: 1-alpha,25-dihydroxyvitamin D3 23-h...