prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Lsm10 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,267 | Knockout | Lsm10 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Lsm10 (U7 snRNP-specific Sm-like protein LSM10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, positive regulation of G1/S transition of mitotic cell cycle; MF: RNA binding, U7... |
Does Knockout of Arhgap32 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Arhgap32 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Arhgap32 (Rho GTPase activating protein 32)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, positive regulation of axon extension, positive regulation of neuron migration, signal transduction, small GTPase-mediated signal transductio... |
Does Knockout of Tssk1 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Tssk1 | cell cycle progression | breast epithelium | Gene: Tssk1 (testis-specific serine kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, peptidyl-serine phosphorylation, protein phosphorylation, spermatid development, spermatogenesis; MF: ATP binding, kinase activity, magnesium ion binding, m... |
Does Knockout of Ddost in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Ddost | protein/peptide distribution | Microglial Cell Line | Gene: Ddost (dolichyl-di-phosphooligosaccharide-protein glycotransferase)
Type: protein-coding
Summary: Predicted to enable enzyme activator activity. Predicted to be involved in several processes, including T cell activation; protein N-linked glycosylation via asparagine; and regulation of protein stab... |
Does Knockout of Gcsh in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Gcsh | cell proliferation | Mouse kidney carcinoma cell | Gene: Gcsh (glycine cleavage system protein H (aminomethyl carrier))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycine catabolic process, glycine decarboxylation via glycine cleavage system; MF: aminomethyltransferase activity, enzyme binding; CC: glycine cleavage c... |
Does Knockout of Scly in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Scly | protein/peptide distribution | Microglial Cell Line | Gene: Scly (selenocysteine lyase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, negative regulation of cellular response to oxidative stress, response to insulin, selenium compound metabolic process, selenocysteine catabolic process; MF: amino a... |
Does Knockout of Igf2r in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Igf2r | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Igf2r (insulin-like growth factor 2 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, animal organ regeneration, host-mediated activation of viral process, liver development, lysosomal transport, positive regulat... |
Does Knockout of Sdcbp2 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Sdcbp2 | response to bacteria | renal medulla cell line | Gene: Sdcbp2 (syndecan binding protein (syntenin) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation; MF: identical protein binding, lipid binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein heterodimerization act... |
Does Knockout of Pfkm in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Pfkm | protein/peptide accumulation | Embryonic Cell Line | Gene: Pfkm (phosphofructokinase, muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, carbohydrate phosphorylation, fructose 1,6-bisphosphate metabolic process, fructose 6-phosphate metabolic process, glucose homeostasis, glycogen catabolic proces... |
Does Knockout of Rgmb in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Rgmb | cell proliferation | Mouse kidney carcinoma cell | Gene: Rgmb (repulsive guidance molecule family member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, cell adhesion, positive regulation of DNA-templated transcription, positive regulation of macromolecule metabolic process, regulation of primary... |
Does Knockout of Sdhc in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,264 | Knockout | Sdhc | cell proliferation | Colonic Cancer Cell Line | Gene: Sdhc (succinate dehydrogenase complex, subunit C, integral membrane protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, tricarboxylic acid cycle; ... |
Does Knockout of Teddm2 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Teddm2 | cell proliferation | Embryonic Stem Cell Line | Gene: Teddm2 (transmembrane epididymal family member 2)
Type: protein-coding
Summary: Orthologous to human TEDDM2P (transmembrane epididymal protein 2, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
... |
Does Knockout of Csrnp2 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,682 | Knockout | Csrnp2 | protein/peptide distribution | myoblast cell line | Gene: Csrnp2 (cysteine-serine-rich nuclear protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription... |
Does Knockout of Kctd19 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Kctd19 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Kctd19 (potassium channel tetramerisation domain containing 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, male meiotic nuclear division, meiotic cell cycle, protein homooligomerization; CC: cellular_component, nucleus
Pathways:
... |
Does Knockout of Bicdl2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Bicdl2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Bicdl2 (BICD family like cargo adaptor 2)
Type: protein-coding
Summary: Enables small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and vesicle transport along microtubule. Orthologous to human BICDL2 (BICD family like cargo adaptor 2). [provided by Alli... |
Does Knockout of Slc35c1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Slc35c1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Slc35c1 (solute carrier family 35, member C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' GDP-L-fucose biosynthetic process, GDP-L-fucose salvage, GDP-fucose import into Golgi lumen, glycolipid biosynthetic process, negative regulation of Notch signali... |
Does Knockout of Wdr20rt in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Wdr20rt | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Wdr20rt (WD repeat domain 20, retrogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: deubiquitinase activator activity, molecular_function; CC: cellular_component, cytoplasm, nucleus
Pathways:
UniProt: Q9D5R2
Entrez ID: 70948 |
Does Knockout of Pfn1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Pfn1 | protein/peptide distribution | myoblast cell line | Gene: Pfn1 (profilin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, modification of postsynaptic actin cytoskeleton, modulation of chemical synaptic transmission, negative regulation of actin filament bundle assembly, negative regulati... |
Does Knockout of Ccdc14 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 165 | Knockout | Ccdc14 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ccdc14 (coiled-coil domain containing 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein localization to centrosome; CC: centriolar satellite, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule cytoskeleton
Pathways:
... |
Does Knockout of Lect2 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Lect2 | cell cycle progression | breast epithelium | Gene: Lect2 (leukocyte cell-derived chemotaxin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemotaxis, negative regulation of Wnt signaling pathway; MF: identical protein binding, metal ion binding
Pathways:
UniProt: O88803
Entrez ID: 168... |
Does Knockout of Sh2d1b2 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Sh2d1b2 | protein/peptide accumulation | Embryonic Cell Line | Gene: Sh2d1b2 (SH2 domain containing 1B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune system process, innate immune response, natural killer cell mediated cytotoxicity, negative regulation of natural killer cell mediated cytotoxicity, ... |
Does Knockout of Ltn1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Ltn1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Ltn1 (listerin E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein autoubiquitination, protein ubiquitination, rescue of stalled ribosome, ribosome-associated ubiquitin-dependent protein catabolic process; MF: metal ion binding, ri... |
Does Knockout of Haao in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Haao | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Haao (3-hydroxyanthranilate 3,4-dioxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' NAD+ biosynthetic process from L-tryptophan, L-tryptophan catabolic process, NAD+ biosynthetic process, anthranilate metabolic process, dicarboxylic acid metabolic... |
Does Knockout of Smco4 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Smco4 | cell proliferation | Colonic Cancer Cell Line | Gene: Smco4 (single-pass membrane protein with coiled-coil domains 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q9JIS3
Entrez ID: 170748 |
Does Knockout of Spryd7 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Spryd7 | response to virus | Neuroblastoma Cell Line | Gene: Spryd7 (SPRY domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3TFQ1
Entrez ID: 66674 |
Does Knockout of Pnpla8 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,178 | Knockout | Pnpla8 | tumorigenicity | Colonic Cancer Cell Line | Gene: Pnpla8 (patatin-like phospholipase domain containing 8)
Type: protein-coding
Summary: Enables calcium-independent phospholipase A2 activity. Involved in cardiolipin metabolic process; regulation of cellular response to oxidative stress; and triglyceride homeostasis. Located in mitochondrion and pe... |
Does Knockout of Gm14399 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Gm14399 | cell proliferation | Melanoma Cell Line | Gene: Gm14399 (predicted gene 14399)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II c... |
Does Knockout of Fn3k in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,178 | Knockout | Fn3k | tumorigenicity | Colonic Cancer Cell Line | Gene: Fn3k (fructosamine 3 kinase)
Type: protein-coding
Summary: Enables protein-fructosamine 3-kinase activity. Involved in peptidyl-lysine deglycation. Acts upstream of or within fructosamine metabolic process. Is active in cytosol. Orthologous to human FN3K (fructosamine 3 kinase). [provided by Allia... |
Does Knockout of Dsg1a in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Dsg1a | cell proliferation | Embryonic Stem Cell Line | Gene: Dsg1a (desmoglein 1 alpha)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signali... |
Does Knockout of Capzb in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Capzb | cell proliferation | Regulatory T cell | Gene: Capzb (capping actin protein of muscle Z-line subunit beta)
Type: protein-coding
Summary: This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein ... |
Does Knockout of Cntn4 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,177 | Knockout | Cntn4 | tumorigenicity | Colonic Cancer Cell Line | Gene: Cntn4 (contactin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cell adhesion, negative regulation of neuron differentiation, nervous system development, neuron projection development; CC: extracellular region, membrane, neuron projection, pla... |
Does Knockout of Twnk in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Twnk | response to bacteria | macrophage | Gene: Twnk (twinkle mtDNA helicase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, mitochondrial DNA replication, mitochondrial transcription, protein hexamerization; MF: 5'-3' DNA helicase activity, ATP binding, ATP hydrol... |
Does Knockout of 1700034E13Rik in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | 1700034E13Rik | protein/peptide distribution | myoblast cell line | Gene: 1700034E13Rik (RIKEN cDNA 1700034E13 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q9D2T6
Entrez ID: 78414 |
Does Knockout of Zfp27 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Zfp27 | cell proliferation | Colonic Cancer Cell Line | Gene: Zfp27 (zinc finger protein 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: metal ion binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Gene expres... |
Does Knockout of Tagln in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Tagln | cell proliferation | Melanoma Cell Line | Gene: Tagln (transgelin)
Type: protein-coding
Summary: This gene encodes a smooth muscle cell-specific cytoskeletal protein. The encoded protein is structurally similar to calponin, an actin-binding protein. In mouse models of atherosclerosis the gene product may be involved in plaque cell and atheroscl... |
Does Knockout of Klf5 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Klf5 | cell proliferation | Mouse kidney carcinoma cell | Gene: Klf5 (Kruppel-like transcription factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cellular response to endothelin, cellular response to leukemia inhibitory factor, intestinal epithelial cell development, microvillus assembly, myotube different... |
Does Knockout of Smok3c in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Smok3c | cell proliferation | Mouse kidney carcinoma cell | Gene: Smok3c (sperm motility kinase 3C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: A0A087WS... |
Does Knockout of Elmod2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Elmod2 | cell proliferation | Colonic Cancer Cell Line | Gene: Elmod2 (ELMO/CED-12 domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of defense response to virus; MF: GTPase activator activity
Pathways:
UniProt: Q8BGF6
Entrez ID: 244548 |
Does Knockout of Rhox1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Rhox1 | protein/peptide distribution | myoblast cell line | Gene: Rhox1 (reproductive homeobox 1)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain. [provi... |
Does Knockout of Ubash3b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Ubash3b | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Ubash3b (ubiquitin associated and SH3 domain containing, B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen-activated signaling pathway, collagen-activated tyrosine kinase receptor signaling pathway, establishment of localization in cell, negative regulatio... |
Does Knockout of Stmn1 in Microglial Cell Line causally result in response to virus? | 0 | 1,438 | Knockout | Stmn1 | response to virus | Microglial Cell Line | Gene: Stmn1 (stathmin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, cell differentiation, establishment of skin barrier, hepatocyte growth factor receptor signaling pathway, microtubule depolymerization, mitotic cytokinesis, mitotic spindle organization... |
Does Knockout of Nup160 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Nup160 | cell cycle progression | breast epithelium | Gene: Nup160 (nucleoporin 160)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, nephron development, nucleocytoplasmic transport, protein transport; MF: structural constituent of nuclear pore; CC: kinetochore, nuclear envelope, nuc... |
Does Knockout of Enpp2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Enpp2 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Enpp2 (ectonucleotide pyrophosphatase/phosphodiesterase 2)
Type: protein-coding
Summary: This gene encodes a member of the phosphodiesterase and nucleotide pyrophosphatase family of bifunctional enzymes that hydrolize phosphodiester bonds of various nucleotides. The encoded protein undergoes prote... |
Does Knockout of Megf6 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Megf6 | cell proliferation | Mouse kidney carcinoma cell | Gene: Megf6 (multiple EGF-like-domains 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, vesicle-mediated transport; MF: calcium ion binding, molecular_function, scavenger receptor activity; CC: extracellular matrix, extracellular region
Path... |
Does Knockout of Hsd3b3 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Hsd3b3 | cell proliferation | Melanoma Cell Line | Gene: Hsd3b3 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: C21-steroid hormone biosynthetic process, C21-steroid hormone metabolic process, androgen biosynthetic process, negative regulation ... |
Does Knockout of Slc16a8 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,174 | Knockout | Slc16a8 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Slc16a8 (solute carrier family 16 (monocarboxylic acid transporters), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lactate transmembrane transport, monocarboxylic acid transport, transmembrane transport; MF: monocarboxylic acid transmembrane transporter... |
Does Knockout of Glis2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Glis2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Glis2 (GLIS family zinc finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell differentiation involved in kidney development, central nervous system development, hematopoietic stem cell homeostasis, kidney development, negative regulat... |
Does Knockout of Aqp11 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Aqp11 | phagocytosis | macrophage | Gene: Aqp11 (aquaporin 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosomal lumen acidification, glycerol transmembrane transport, hydrogen peroxide transmembrane transport, intracellular oxygen homeostasis, intracellular water homeostasis, kidney development, ne... |
Does Knockout of Gm17330 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Gm17330 | cell proliferation | Colonic Cancer Cell Line | Gene: Gm17330 (predicted gene, 17330)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Jund in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | Jund | protein/peptide distribution | myoblast cell line | Gene: Jund (jun D proto-oncogene)
Type: protein-coding
Summary: The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alte... |
Does Knockout of Ormdl3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Ormdl3 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ormdl3 (ORM1-like 3 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide metabolic process, intracellular sphingolipid homeostasis, motor behavior, myelination, negative regulation of B cell apoptotic process, negative regulation of ceramide bio... |
Does Knockout of D630033O11Rik in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | D630033O11Rik | protein/peptide distribution | myoblast cell line | Gene: D630033O11Rik (RIKEN cDNA D630033O11 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Imp4 in Melanoma Cell Line causally result in cell proliferation? | 1 | 1,270 | Knockout | Imp4 | cell proliferation | Melanoma Cell Line | Gene: Imp4 (IMP4, U3 small nucleolar ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: rRNA binding, rRNA primary transcript binding, snoRNA binding; CC: Mpp10 complex, fibrilla... |
Does Knockout of Islr2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Islr2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Islr2 (immunoglobulin superfamily containing leucine-rich repeat 2)
Type: protein-coding
Summary: Involved in positive regulation of axon extension. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary syste... |
Does Knockout of Selenbp2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Selenbp2 | cell proliferation | Melanoma Cell Line | Gene: Selenbp2 (selenium binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: methanethiol oxidase activity, selenium binding; CC: cytoplasm, cytosol, fibrillar center, membrane, nucleolus, nucleus
Pathways: Sulfur metabolism - Mus musculus (mouse)
... |
Does Knockout of Tecr in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Tecr | protein/peptide accumulation | Embryonic Cell Line | Gene: Tecr (trans-2,3-enoyl-CoA reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid elongation, fatty acid metabolic process, lipid metabolic process, sphingolipid metabolic process, steroid biosynthetic process, very lon... |
Does Knockout of Marcks in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Marcks | cell proliferation | Mouse kidney carcinoma cell | Gene: Marcks (myristoylated alanine rich protein kinase C substrate)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin crosslink formation, actin filament bundle assembly, actin filament organization, apoptotic process, cell-substrate adhesion, central nervous system ... |
Does Knockout of Alg11 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,171 | Knockout | Alg11 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Alg11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation; MF: GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity, glycosyltrans... |
Does Knockout of Serpine1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Serpine1 | cell proliferation | Melanoma Cell Line | Gene: Serpine1 (serine (or cysteine) peptidase inhibitor, clade E, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to transforming growth factor beta stimulus, cellula... |
Does Knockout of Pira2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Pira2 | cell proliferation | Colonic Cancer Cell Line | Gene: Pira2 (paired-Ig-like receptor A2)
Type: protein-coding
Summary: Predicted to enable several functions, including IgM binding activity; coreceptor activity; and inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating ... |
Does Knockout of Ccbe1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Ccbe1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Ccbe1 (collagen and calcium binding EGF domains 1)
Type: protein-coding
Summary: Predicted to enable collagen binding activity and protease binding activity. Involved in positive regulation of angiogenesis and positive regulation of lymphangiogenesis. Acts upstream of or within several processes, ... |
Does Knockout of Slx4 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Slx4 | response to virus | Microglial Cell Line | Gene: Slx4 (SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae))
Type: protein-coding
Summary: This gene encodes a protein containing a BTB (POZ) domain that comprises a subunit of structure-specific endonucleases. The encoded protein aids in the resolution of DNA secondary structures t... |
Does Knockout of Shroom1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 163 | Knockout | Shroom1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Shroom1 (shroom family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle assembly, cell morphogenesis; MF: actin binding, actin filament binding, myosin II binding; CC: adherens junction, apical junction complex, apical plasma membrane,... |
Does Knockout of Fxr2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 163 | Knockout | Fxr2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Fxr2 (FMR1 autosomal homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, dentate gyrus development, mRNA destabilization, mRNA transport, negative regulation of gene expression, positive regulation of long-term neuronal synaptic plas... |
Does Knockout of Ccdc183 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Ccdc183 | cell proliferation | Melanoma Cell Line | Gene: Ccdc183 (coiled-coil domain containing 183)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2AJB1
Entrez ID: 77058 |
Does Knockout of Gclm in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Gclm | cell proliferation | Embryonic Stem Cell Line | Gene: Gclm (glutamate-cysteine ligase, modifier subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic mitochondrial changes, blood vessel diameter maintenance, cellular response to fibroblast growth factor stimulus, cellular response to follicle-stimulating h... |
Does Knockout of Pla2g10 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Pla2g10 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Pla2g10 (phospholipase A2, group X)
Type: protein-coding
Summary: This gene encodes a member of the phospholipase A2 family of lipolytic enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate ... |
Does Knockout of Zfp773 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Zfp773 | cell proliferation | Melanoma Cell Line | Gene: Zfp773 (zinc finger protein 773)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA ... |
Does Knockout of Heph in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Heph | cell proliferation | Colonic Cancer Cell Line | Gene: Heph (hephaestin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intestinal iron absorption, iron ion transport, monoatomic ion transport, multicellular organismal-level iron ion homeostasis, positive regulation of iron export across plasma membrane; MF: copper ion... |
Does Knockout of Mon2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Mon2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Mon2 (MON2 homolog, regulator of endosome to Golgi trafficking)
Type: protein-coding
Summary: Predicted to be involved in Golgi to endosome transport. Predicted to be located in early endosome membrane. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided... |
Does Knockout of Csrp3 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Csrp3 | cell cycle progression | breast epithelium | Gene: Csrp3 (cysteine and glycine-rich protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-tubule organization, cardiac muscle contraction, cardiac muscle hypertrophy, cardiac muscle tissue development, cardiac myofibril assembly, cell differentiation, detection ... |
Does Knockout of Dpy19l3 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Dpy19l3 | response to virus | Neuroblastoma Cell Line | Gene: Dpy19l3 (dpy-19 like C-mannosyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
... |
Does Knockout of Cacna1g in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Cacna1g | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Cacna1g (calcium channel, voltage-dependent, T type, alpha 1G subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, artery smooth muscle contraction, calcium ion import, calcium ion transmembrane transport, calcium ion transport, calcium ion tra... |
Does Knockout of Mucl1 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Mucl1 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Mucl1 (mucin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q62265
Entrez ID: 20771 |
Does Knockout of Ifi27 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Ifi27 | protein/peptide accumulation | Embryonic Cell Line | Gene: Ifi27 (interferon, alpha-inducible protein 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intrinsic apoptotic signaling pathway, negative regulation of transcription by RNA polymerase II, regulation of protein export from nucleus; MF: RNA polymerase II-specific... |
Does Knockout of Hdhd5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Hdhd5 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Hdhd5 (haloacid dehalogenase like hydrolase domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: Q91WM2
Entrez ID: 214932 |
Does Knockout of Lpcat1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Lpcat1 | cell proliferation | Melanoma Cell Line | Gene: Lpcat1 (lysophosphatidylcholine acyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycerolipid metabolic process, lipid metabolic process, negative regulation of phosphatidylcholine biosynthetic process, phosphatidylcholine acyl-chain remodeling, ph... |
Does Knockout of Syne3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Syne3 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Syne3 (spectrin repeat containing, nuclear envelope family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, establishment of protein localization to membrane, nuclear migration, regulation of cell shape; MF: actin filament binding... |
Does Knockout of Stkld1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Stkld1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Stkld1 (serine/threonine kinase-like domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity
Pathways:
UniProt: Q80YS9
Entrez I... |
Does Knockout of Lilra6 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,175 | Knockout | Lilra6 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Lilra6 (leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, cytokine-mediated signaling pathway, immune response-regulating signaling pathway; MF: Ig... |
Does Knockout of Tmco3 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation? | 1 | 2,411 | Knockout | Tmco3 | cell proliferation | Cytotoxic T-lymphocyte (CD8+ T cells) | Gene: Tmco3 (transmembrane and coiled-coil domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, monoatomic cation transport, monoatomic ion transport, potassium ion transmembrane transport, proton transmembrane transport, transmembrane transport;... |
Does Knockout of Adam8 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,181 | Knockout | Adam8 | tumorigenicity | Colonic Cancer Cell Line | Gene: Adam8 (a disintegrin and metallopeptidase domain 8)
Type: protein-coding
Summary: This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extr... |
Does Knockout of Emp2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Emp2 | cell proliferation | Melanoma Cell Line | Gene: Emp2 (epithelial membrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell mediated cytotoxicity, actin filament organization, actin-mediated cell contraction, apoptotic process, bleb assembly, blood vessel endothelial cell migration, caveola assemb... |
Does Knockout of App in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | App | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: App (amyloid beta precursor protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Notch signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G prot... |
Does Knockout of Arhgap9 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Arhgap9 | cell proliferation | Colonic Cancer Cell Line | Gene: Arhgap9 (Rho GTPase activating protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity, phosphatidylinositol-3,4,5-trisphosphate binding; CC: cytoplasm, plasma membrane
... |
Does Knockout of Cenpq in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Cenpq | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Cenpq (centromere protein Q)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, metaphase chromosome alignment, positive regulation of protein localization to kinetochore; CC: actin cytoskeleton, chromosome, chromosome, centromeric region, inner... |
Does Knockout of Eny2 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Eny2 | cell cycle progression | breast epithelium | Gene: Eny2 (ENY2 transcription and export complex 2 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, mRNA export from nucleus, mRNA transport, negative regulation of insulin secretion involved in cellular response to glucose stimulus, poly(... |
Does Knockout of Slc44a3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Slc44a3 | protein/peptide distribution | myoblast cell line | Gene: Slc44a3 (solute carrier family 44, member 3)
Type: protein-coding
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in gut and olfactory epithelium. Orthologous to human SLC44A3 (so... |
Does Knockout of Gm20831 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Gm20831 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Gm20831 (predicted gene, 20831)
Type: protein-coding
Summary: predicted gene, 20831
Gene Ontology:
Pathways:
UniProt: Q3TTD8
Entrez ID: 100040223 |
Does Knockout of Sfn in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Sfn | protein/peptide accumulation | Embryonic Cell Line | Gene: Sfn (stratifin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cAMP/PKA signal transduction, cytolysis in another organism, defense response to bacterium, establishment of protein localization, establishment of skin barrier, intracellular protein localization, intr... |
Does Knockout of Defb33 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Defb33 | cell proliferation | Colonic Cancer Cell Line | Gene: Defb33 (defensin beta 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response, defense response to bacterium, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity; CC: extracellular region, extracellular sp... |
Does Knockout of Ms4a10 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Ms4a10 | cell proliferation | Melanoma Cell Line | Gene: Ms4a10 (membrane-spanning 4-domains, subfamily A, member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q99N03
Entrez ID: 69826 |
Does Knockout of Trim52 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Trim52 | protein/peptide distribution | myoblast cell line | Gene: Trim52 (tripartite motif-containing 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, innate immune response, positive regulation of canonical NF-kappaB signal transduction, protein autoubiquitination, protein ubiquitination; MF: metal i... |
Does Knockout of Rhox2h in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Rhox2h | cell cycle progression | breast epithelium | Gene: Rhox2h (reproductive homeobox 2H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding... |
Does Knockout of Sez6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Sez6 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Sez6 (seizure related gene 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult locomotory behavior, cerebellar Purkinje cell layer development, excitatory postsynaptic potential, negative regulation of dendrite development, positive regulation of dendrite devel... |
Does Knockout of Nyap1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Nyap1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Nyap1 (neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuron projection morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction
Pathways:
UniProt: Q6P... |
Does Knockout of Oxsr1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Oxsr1 | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Oxsr1 (oxidative-stress responsive 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell volume homeostasis, cellular hyperosmotic response, cellular hypotonic response, cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, chemokine (... |
Does Knockout of Ube3b in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Ube3b | protein/peptide accumulation | Regulatory T cell | Gene: Ube3b (ubiquitin protein ligase E3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein polyubiquitination, protein ubiquitination, regulation of postsynapse assembly, ubiquitin-dependent protein catabolic process; MF: transferase activity, ubiquitin protein li... |
Does Knockout of Bbx in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Bbx | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Bbx (bobby sox HMG box containing)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within bone development. Pred... |
Does Knockout of P2ry1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | P2ry1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: P2ry1 (purinergic receptor P2Y, G-protein coupled 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled adenosine receptor signaling pathway, G protein-coupled purinergic nucleotide receptor signaling pathway, G protein-coupled receptor signaling path... |
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