prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Lsm10 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Lsm10
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Lsm10 (U7 snRNP-specific Sm-like protein LSM10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, positive regulation of G1/S transition of mitotic cell cycle; MF: RNA binding, U7 snRNA binding, histone pre-mRNA DCP binding, snRNA binding; CC: Cajal body, U7 snRNP, cytoplasmic U snRNP body, nuclear body, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs
UniProt: Q8QZX5
Entrez ID: 116748
|
Does Knockout of Arhgap32 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Arhgap32
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Arhgap32 (Rho GTPase activating protein 32)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, positive regulation of axon extension, positive regulation of neuron migration, signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity, phosphatidylinositol binding, phosphatidylinositol phosphate binding, protein binding; CC: Golgi apparatus, Golgi membrane, actin cytoskeleton, cell cortex, cell projection, cytoplasm, dendritic spine, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, fibrillar center, glutamatergic synapse, membrane, nucleoplasm, postsynaptic density, synapse
Pathways: Adherens junctions interactions, CDC42 GTPase cycle, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, cyclic AMP biosynthesis
UniProt: Q811P8
Entrez ID: 330914
|
Does Knockout of Tssk1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Tssk1
|
cell cycle progression
|
breast epithelium
|
Gene: Tssk1 (testis-specific serine kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, peptidyl-serine phosphorylation, protein phosphorylation, spermatid development, spermatogenesis; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: acrosomal vesicle, cell projection, cilium, cytoplasm, cytoplasmic vesicle, motile cilium
Pathways:
UniProt: Q61241
Entrez ID: 22114
|
Does Knockout of Ddost in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Ddost
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Ddost (dolichyl-di-phosphooligosaccharide-protein glycotransferase)
Type: protein-coding
Summary: Predicted to enable enzyme activator activity. Predicted to be involved in several processes, including T cell activation; protein N-linked glycosylation via asparagine; and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ir. Orthologous to human DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: T cell activation, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, regulation of protein stability, response to cytokine; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, Innate Immune System, N-Glycan biosynthesis - Mus musculus (mouse), Neutrophil degranulation, PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: O54734
Entrez ID: 13200
|
Does Knockout of Gcsh in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Gcsh
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gcsh (glycine cleavage system protein H (aminomethyl carrier))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycine catabolic process, glycine decarboxylation via glycine cleavage system; MF: aminomethyltransferase activity, enzyme binding; CC: glycine cleavage complex, mitochondrion
Pathways: Glycine degradation, Glycine, serine and threonine metabolism - Mus musculus (mouse), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Glyoxylate metabolism and glycine degradation, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Post-translational protein modification, Protein lipoylation
UniProt: Q91WK5
Entrez ID: 68133
|
Does Knockout of Scly in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Scly
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Scly (selenocysteine lyase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, negative regulation of cellular response to oxidative stress, response to insulin, selenium compound metabolic process, selenocysteine catabolic process; MF: amino acid binding, lyase activity, protein homodimerization activity, selenocysteine lyase activity, transferase activity, vitamin B6 binding; CC: Golgi apparatus, catalytic complex, cytoplasm, cytosol
Pathways: Metabolism, Metabolism of amino acids and derivatives, Metabolism of ingested SeMet, Sec, MeSec into H2Se, Selenoamino acid metabolism, Selenocompound metabolism - Mus musculus (mouse)
UniProt: Q9JLI6
Entrez ID: 50880
|
Does Knockout of Igf2r in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Igf2r
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Igf2r (insulin-like growth factor 2 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, animal organ regeneration, host-mediated activation of viral process, liver development, lysosomal transport, positive regulation of apoptotic process, post-embryonic development, regulation of apoptotic process, response to retinoic acid, response to tetrachloromethane, spermatogenesis; MF: D-mannose binding, G-protein alpha-subunit binding, enzyme binding, identical protein binding, insulin-like growth factor II binding, insulin-like growth factor binding, phosphoprotein binding, protein binding, retinoic acid binding, retromer complex binding, signaling receptor activity; CC: Golgi apparatus, Golgi membrane, cell surface, clathrin coat, early endosome, endocytic vesicle, endomembrane system, endosome, endosome membrane, extracellular space, late endosome, membrane, nuclear envelope lumen, nucleus, perinuclear region of cytoplasm, plasma membrane, trans-Golgi network, trans-Golgi network transport vesicle
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Endocytosis - Mus musculus (mouse), Golgi Associated Vesicle Biogenesis, Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Lysosome - Mus musculus (mouse), Membrane Trafficking, Neutrophil degranulation, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q07113
Entrez ID: 16004
|
Does Knockout of Sdcbp2 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Sdcbp2
|
response to bacteria
|
renal medulla cell line
|
Gene: Sdcbp2 (syndecan binding protein (syntenin) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation; MF: identical protein binding, lipid binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein heterodimerization activity, protein homodimerization activity; CC: Golgi apparatus, cytoplasm, cytosol, membrane, nuclear speck, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q99JZ0
Entrez ID: 228765
|
Does Knockout of Pfkm in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Pfkm
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Pfkm (phosphofructokinase, muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, carbohydrate phosphorylation, fructose 1,6-bisphosphate metabolic process, fructose 6-phosphate metabolic process, glucose homeostasis, glycogen catabolic process, glycolysis from storage polysaccharide through glucose-1-phosphate, glycolytic process, glycolytic process through fructose-6-phosphate, muscle cell cellular homeostasis, positive regulation of insulin secretion, positive regulation of transcription by RNA polymerase II; MF: 6-phosphofructokinase activity, AMP binding, ATP binding, carbohydrate binding, catalytic activity, fructose binding, fructose-6-phosphate binding, identical protein binding, kinase activity, kinase binding, metal ion binding, nucleotide binding, phosphofructokinase activity, protein binding, transferase activity; CC: 6-phosphofructokinase complex, apical plasma membrane, cell projection, cilium, cytoplasm, cytosol, membrane, motile cilium, nucleus, sperm principal piece
Pathways: AMPK signaling pathway - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Fructose and mannose metabolism - Mus musculus (mouse), Galactose metabolism - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway - Mus musculus (mouse), RNA degradation - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), glycolysis I, glycolysis III
UniProt: P47857
Entrez ID: 18642
|
Does Knockout of Rgmb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Rgmb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rgmb (repulsive guidance molecule family member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, cell adhesion, positive regulation of DNA-templated transcription, positive regulation of macromolecule metabolic process, regulation of primary metabolic process, signal transduction; MF: coreceptor activity, identical protein binding; CC: endoplasmic reticulum-Golgi intermediate compartment, membrane, membrane raft, plasma membrane, side of membrane
Pathways: TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: Q7TQ33
Entrez ID: 68799
|
Does Knockout of Sdhc in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Sdhc
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sdhc (succinate dehydrogenase complex, subunit C, integral membrane protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, tricarboxylic acid cycle; MF: electron transfer activity, heme binding, metal ion binding; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex II (succinate dehydrogenase)
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II, aerobic respiration -- electron donors reaction list
UniProt: Q9CZB0
Entrez ID: 66052
|
Does Knockout of Teddm2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Teddm2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Teddm2 (transmembrane epididymal family member 2)
Type: protein-coding
Summary: Orthologous to human TEDDM2P (transmembrane epididymal protein 2, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: D3YXN9, Q208S0
Entrez ID: 240817
|
Does Knockout of Csrnp2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Csrnp2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Csrnp2 (cysteine-serine-rich nuclear protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, phosphatase binding, sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q8BGQ2
Entrez ID: 207785
|
Does Knockout of Kctd19 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Kctd19
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Kctd19 (potassium channel tetramerisation domain containing 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, male meiotic nuclear division, meiotic cell cycle, protein homooligomerization; CC: cellular_component, nucleus
Pathways:
UniProt: Q562E2
Entrez ID: 279499
|
Does Knockout of Bicdl2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Bicdl2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Bicdl2 (BICD family like cargo adaptor 2)
Type: protein-coding
Summary: Enables small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and vesicle transport along microtubule. Orthologous to human BICDL2 (BICD family like cargo adaptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi to secretory granule transport, vesicle transport along microtubule
Pathways:
UniProt: Q8CHW5
Entrez ID: 212733
|
Does Knockout of Slc35c1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Slc35c1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Slc35c1 (solute carrier family 35, member C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' GDP-L-fucose biosynthetic process, GDP-L-fucose salvage, GDP-fucose import into Golgi lumen, glycolipid biosynthetic process, negative regulation of Notch signaling pathway; MF: GDP-fucose transmembrane transporter activity, antiporter activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, GDP-fucose biosynthesis, Metabolism of proteins, Post-translational protein modification, SLC-mediated transmembrane transport, Synthesis of substrates in N-glycan biosythesis, Transport of nucleotide sugars, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q8BLX4
Entrez ID: 228368
|
Does Knockout of Wdr20rt in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Wdr20rt
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Wdr20rt (WD repeat domain 20, retrogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: deubiquitinase activator activity, molecular_function; CC: cellular_component, cytoplasm, nucleus
Pathways:
UniProt: Q9D5R2
Entrez ID: 70948
|
Does Knockout of Pfn1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Pfn1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pfn1 (profilin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, modification of postsynaptic actin cytoskeleton, modulation of chemical synaptic transmission, negative regulation of actin filament bundle assembly, negative regulation of stress fiber assembly, neural tube closure, positive regulation of DNA metabolic process, positive regulation of actin filament bundle assembly, positive regulation of actin filament polymerization, positive regulation of epithelial cell migration, positive regulation of ruffle assembly, positive regulation of stress fiber assembly, positive regulation of transcription by RNA polymerase II, positive regulation of viral transcription, protein stabilization, regulation of actin filament organization, regulation of actin filament polymerization, regulation of actin polymerization or depolymerization, regulation of transcription by RNA polymerase II, synapse maturation; MF: actin binding, actin monomer binding, actin monomer sequestering activity, adenyl-nucleotide exchange factor activity, phosphatidylinositol-4,5-bisphosphate binding, phosphotyrosine residue binding, proline-rich region binding, protein binding, signaling receptor binding, small GTPase binding; CC: Schaffer collateral - CA1 synapse, cell cortex, cytoplasm, cytoskeleton, cytosol, extracellular region, glutamatergic synapse, nucleus, parallel fiber to Purkinje cell synapse, postsynapse, presynapse
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Axon guidance, Beta-catenin independent WNT signaling, Developmental Biology, Nervous system development, PCP/CE pathway, RHO GTPase Effectors, RHO GTPases Activate Formins, Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT
UniProt: P62962
Entrez ID: 18643
|
Does Knockout of Ccdc14 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Ccdc14
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ccdc14 (coiled-coil domain containing 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein localization to centrosome; CC: centriolar satellite, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule cytoskeleton
Pathways:
UniProt: Q8K2J4
Entrez ID: 239839
|
Does Knockout of Lect2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Lect2
|
cell cycle progression
|
breast epithelium
|
Gene: Lect2 (leukocyte cell-derived chemotaxin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemotaxis, negative regulation of Wnt signaling pathway; MF: identical protein binding, metal ion binding
Pathways:
UniProt: O88803
Entrez ID: 16841
|
Does Knockout of Sh2d1b2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Sh2d1b2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sh2d1b2 (SH2 domain containing 1B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune system process, innate immune response, natural killer cell mediated cytotoxicity, negative regulation of natural killer cell mediated cytotoxicity, positive regulation of natural killer cell mediated cytotoxicity, regulation of natural killer cell activation; CC: cellular_component, cytoplasm
Pathways: Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: Q45HK4
Entrez ID: 545378
|
Does Knockout of Ltn1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Ltn1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ltn1 (listerin E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein autoubiquitination, protein ubiquitination, rescue of stalled ribosome, ribosome-associated ubiquitin-dependent protein catabolic process; MF: metal ion binding, ribosomal large subunit binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: RQC complex, cytoplasm, cytosol, cytosolic ribosome
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation
UniProt: Q6A009
Entrez ID: 78913
|
Does Knockout of Haao in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Haao
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Haao (3-hydroxyanthranilate 3,4-dioxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' NAD+ biosynthetic process from L-tryptophan, L-tryptophan catabolic process, NAD+ biosynthetic process, anthranilate metabolic process, dicarboxylic acid metabolic process, neuron cellular homeostasis, pyridine nucleotide biosynthetic process, quinolinate biosynthetic process, quinolinate metabolic process, response to cadmium ion, response to zinc ion; MF: 3-hydroxyanthranilate 3,4-dioxygenase activity, dioxygenase activity, ferrous iron binding, iron ion binding, metal ion binding, oxidoreductase activity, oxygen binding; CC: cytoplasm, cytosol, mitochondrial membrane
Pathways: Metabolism, Metabolism of amino acids and derivatives, NAD biosynthesis II (from tryptophan), Tryptophan catabolism, Tryptophan metabolism - Mus musculus (mouse), tryptophan degradation III (eukaryotic), tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
UniProt: Q78JT3
Entrez ID: 107766
|
Does Knockout of Smco4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Smco4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Smco4 (single-pass membrane protein with coiled-coil domains 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q9JIS3
Entrez ID: 170748
|
Does Knockout of Spryd7 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Spryd7
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Spryd7 (SPRY domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3TFQ1
Entrez ID: 66674
|
Does Knockout of Pnpla8 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Pnpla8
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Pnpla8 (patatin-like phospholipase domain containing 8)
Type: protein-coding
Summary: Enables calcium-independent phospholipase A2 activity. Involved in cardiolipin metabolic process; regulation of cellular response to oxidative stress; and triglyceride homeostasis. Located in mitochondrion and peroxisome. Orthologous to human PNPLA8 (patatin like phospholipase domain containing 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: arachidonate metabolic process, arachidonate secretion, cardiolipin metabolic process, fatty acid metabolic process, intracellular signal transduction, linoleic acid metabolic process, lipid catabolic process, lipid homeostasis, lipid metabolic process, phosphatidylcholine catabolic process, phosphatidylethanolamine catabolic process, prostaglandin biosynthetic process, regulation of cellular response to oxidative stress, triglyceride homeostasis; MF: calcium-independent phospholipase A2 activity, hydrolase activity, phosphatidylcholine lysophospholipase activity, phospholipase A1 activity, phospholipase A2 activity, phospholipase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial membrane, mitochondrion, peroxisomal membrane, peroxisome
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism
UniProt: Q8K1N1
Entrez ID: 67452
|
Does Knockout of Gm14399 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Gm14399
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gm14399 (predicted gene 14399)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: Q8CFP2, A2ARW8, A2ARW7
Entrez ID: 100043761
|
Does Knockout of Fn3k in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Fn3k
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Fn3k (fructosamine 3 kinase)
Type: protein-coding
Summary: Enables protein-fructosamine 3-kinase activity. Involved in peptidyl-lysine deglycation. Acts upstream of or within fructosamine metabolic process. Is active in cytosol. Orthologous to human FN3K (fructosamine 3 kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: epithelial cell differentiation, fructosamine metabolic process, protein deglycation; MF: ATP binding, kinase activity, nucleotide binding, protein-fructosamine 3-kinase activity, protein-ribulosamine 3-kinase activity, transferase activity; CC: cytosol, mitochondrion
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification
UniProt: Q9ER35
Entrez ID: 63828
|
Does Knockout of Dsg1a in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Dsg1a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dsg1a (desmoglein 1 alpha)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: cell adhesion, cell-cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, protein stabilization; MF: calcium ion binding, gamma-catenin binding, metal ion binding, protein binding; CC: anchoring junction, apical plasma membrane, cell-cell junction, cytoplasm, cytoplasmic side of plasma membrane, desmosome, lateral plasma membrane, membrane, nucleus, plasma membrane
Pathways: Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Q61495
Entrez ID: 13510
|
Does Knockout of Capzb in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Capzb
|
cell proliferation
|
Regulatory T cell
|
Gene: Capzb (capping actin protein of muscle Z-line subunit beta)
Type: protein-coding
Summary: This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein with the barbed end of the actin filament occurs through binding of the amphipathic helix at the C-terminus to the hydrophobic cleft on the actin molecule. This gene is required for a variety of dynamic actin-mediated processes including organization of lamellipodia and filopodia, growth cone morphology and neurite outgrowth in hippocampal neurons, and asymmetric spindle migration and polar body extrusion during oocyte maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: actin cytoskeleton organization, actin filament capping, actin polymerization or depolymerization, barbed-end actin filament capping, cell morphogenesis, cell projection organization, cytoskeleton organization, lamellipodium assembly, muscle cell development, negative regulation of filopodium assembly, negative regulation of microtubule polymerization, neuron projection development, regulation of cell morphogenesis, regulation of lamellipodium assembly, regulation of protein kinase C signaling; MF: actin binding, actin filament binding, beta-tubulin binding, protein binding; CC: F-actin capping protein complex, Schaffer collateral - CA1 synapse, WASH complex, Z disc, asymmetric synapse, brush border, cortical cytoskeleton, cytoplasm, cytoskeletal calyx, cytoskeleton, cytosol, dendritic spine, hippocampal mossy fiber to CA3 synapse, intercalated disc, lamellipodium, membrane, neuronal cell body, postsynaptic density, sarcomere, sperm head, sperm head-tail coupling apparatus
Pathways: Adaptive Immune System, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Endocytosis - Mus musculus (mouse), Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P47757
Entrez ID: 12345
|
Does Knockout of Cntn4 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Cntn4
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Cntn4 (contactin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cell adhesion, negative regulation of neuron differentiation, nervous system development, neuron projection development; CC: extracellular region, membrane, neuron projection, plasma membrane, side of membrane
Pathways:
UniProt: Q69Z26
Entrez ID: 269784
|
Does Knockout of Twnk in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Twnk
|
response to bacteria
|
macrophage
|
Gene: Twnk (twinkle mtDNA helicase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, mitochondrial DNA replication, mitochondrial transcription, protein hexamerization; MF: 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA helicase activity, helicase activity, hydrolase activity, identical protein binding, isomerase activity, lipid binding, nucleotide binding, protease binding, single-stranded DNA binding; CC: membrane, mitochondrial chromosome, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrion
Pathways: DNA Replication, Metabolism of proteins, Mitochondrial protein degradation, Spinocerebellar ataxia - Mus musculus (mouse), Strand-asynchronous mitochondrial DNA replication
UniProt: Q8CIW5
Entrez ID: 226153
|
Does Knockout of 1700034E13Rik in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
1700034E13Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 1700034E13Rik (RIKEN cDNA 1700034E13 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q9D2T6
Entrez ID: 78414
|
Does Knockout of Zfp27 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Zfp27
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfp27 (zinc finger protein 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: metal ion binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: P10077
Entrez ID: 22689
|
Does Knockout of Tagln in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Tagln
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tagln (transgelin)
Type: protein-coding
Summary: This gene encodes a smooth muscle cell-specific cytoskeletal protein. The encoded protein is structurally similar to calponin, an actin-binding protein. In mouse models of atherosclerosis the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: epithelial cell differentiation
Pathways:
UniProt: P37804
Entrez ID: 21345
|
Does Knockout of Klf5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Klf5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Klf5 (Kruppel-like transcription factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cellular response to endothelin, cellular response to leukemia inhibitory factor, intestinal epithelial cell development, microvillus assembly, myotube differentiation involved in skeletal muscle regeneration, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of fat cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by transcription factor localization, regulation of gene expression, regulation of microvillus assembly, regulation of transcription by RNA polymerase II, satellite cell activation involved in skeletal muscle regeneration, skeletal muscle cell differentiation, skeletal muscle satellite cell differentiation, skeletal muscle tissue regeneration; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, MRF binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: Golgi apparatus, nucleoplasm, nucleus, transcription regulator complex
Pathways: Chemical carcinogenesis - receptor activation - Mus musculus (mouse)
UniProt: Q9Z0Z7
Entrez ID: 12224
|
Does Knockout of Smok3c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Smok3c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Smok3c (sperm motility kinase 3C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: A0A087WSF2
Entrez ID: 622486
|
Does Knockout of Elmod2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Elmod2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Elmod2 (ELMO/CED-12 domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of defense response to virus; MF: GTPase activator activity
Pathways:
UniProt: Q8BGF6
Entrez ID: 244548
|
Does Knockout of Rhox1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Rhox1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rhox1 (reproductive homeobox 1)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: Q4TU92, B1APN4
Entrez ID: 385343
|
Does Knockout of Ubash3b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Ubash3b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ubash3b (ubiquitin associated and SH3 domain containing, B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen-activated signaling pathway, collagen-activated tyrosine kinase receptor signaling pathway, establishment of localization in cell, negative regulation of bone resorption, negative regulation of immune system process, negative regulation of osteoclast differentiation, negative regulation of platelet aggregation, negative regulation of signal transduction, platelet activation, platelet aggregation, regulation of osteoclast differentiation, regulation of release of sequestered calcium ion into cytosol; MF: hydrolase activity, identical protein binding, phosphoprotein binding, phosphoprotein phosphatase activity, protein binding, protein tyrosine phosphatase activity, ubiquitin protein ligase binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8BGG7
Entrez ID: 72828
|
Does Knockout of Stmn1 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Stmn1
|
response to virus
|
Microglial Cell Line
|
Gene: Stmn1 (stathmin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, cell differentiation, establishment of skin barrier, hepatocyte growth factor receptor signaling pathway, microtubule depolymerization, mitotic cytokinesis, mitotic spindle organization, negative regulation of Rho protein signal transduction, negative regulation of microtubule polymerization, negative regulation of stress fiber assembly, negative regulation of thrombin-activated receptor signaling pathway, nervous system development, neuron projection development, regulation of cell migration, regulation of microtubule polymerization or depolymerization, response to virus; MF: protein binding, tubulin binding; CC: cytoplasm, cytoskeleton, cytosol, membrane, microtubule, neuron projection
Pathways: MAPK signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse)
UniProt: P54227
Entrez ID: 16765
|
Does Knockout of Nup160 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Nup160
|
cell cycle progression
|
breast epithelium
|
Gene: Nup160 (nucleoporin 160)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, nephron development, nucleocytoplasmic transport, protein transport; MF: structural constituent of nuclear pore; CC: kinetochore, nuclear envelope, nuclear pore, nuclear pore outer ring, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q9Z0W3
Entrez ID: 59015
|
Does Knockout of Enpp2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Enpp2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Enpp2 (ectonucleotide pyrophosphatase/phosphodiesterase 2)
Type: protein-coding
Summary: This gene encodes a member of the phosphodiesterase and nucleotide pyrophosphatase family of bifunctional enzymes that hydrolize phosphodiester bonds of various nucleotides. The encoded protein undergoes proteolytic processing to generate a mature protein with lysophospholipase D activity, catalyzing the cleavage of the choline group from lysophosphatidylcholine to produce lysophosphatidic acid. This gene is expressed in numerous tissues and participates in neural development, obesity, inflammation and oncogenesis. A complete lack of the encoded protein in mice results in aberrant vascular and neuronal development leading to embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cell chemotaxis, chemotaxis, estrous cycle, immune response, lipid catabolic process, lipid metabolic process, negative regulation of cell-matrix adhesion, phosphatidylcholine catabolic process, phospholipid catabolic process, phospholipid metabolic process, positive regulation of cell population proliferation, positive regulation of epithelial cell migration, positive regulation of focal adhesion assembly, positive regulation of lamellipodium morphogenesis, positive regulation of oligodendrocyte differentiation, positive regulation of substrate adhesion-dependent cell spreading, regulation of cell migration, sphingolipid catabolic process, vesicle-mediated transport; MF: alkylglycerophosphoethanolamine phosphodiesterase activity, calcium ion binding, dinucleotide phosphatase activity, hydrolase activity, metal ion binding, nucleic acid binding, phosphatidylcholine lysophospholipase activity, phosphodiesterase I activity, phospholipase D activity, polysaccharide binding, scavenger receptor activity, zinc ion binding; CC: extracellular region, extracellular space, plasma membrane
Pathways: Ether lipid metabolism - Mus musculus (mouse)
UniProt: Q9R1E6
Entrez ID: 18606
|
Does Knockout of Megf6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Megf6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Megf6 (multiple EGF-like-domains 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, vesicle-mediated transport; MF: calcium ion binding, molecular_function, scavenger receptor activity; CC: extracellular matrix, extracellular region
Pathways:
UniProt: F6YCL7, A0A0A0MQ83, B1ASH4
Entrez ID: 230971
|
Does Knockout of Hsd3b3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Hsd3b3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Hsd3b3 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: C21-steroid hormone biosynthetic process, C21-steroid hormone metabolic process, androgen biosynthetic process, negative regulation of iron ion transport, steroid biosynthetic process; MF: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity, catalytic activity, isomerase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, steroid Delta-isomerase activity; CC: cilium, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intercellular bridge, intracellular membrane-bounded organelle, membrane, microtubule cytoskeleton, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion, nucleolus
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Androgen biosynthesis, Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Glucocorticoid biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Mineralocorticoid biosynthesis, Ovarian steroidogenesis - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), biosynthesis of androgens, biosynthesis of corticosteroids
UniProt: P26150
Entrez ID: 15494
|
Does Knockout of Slc16a8 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Slc16a8
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc16a8 (solute carrier family 16 (monocarboxylic acid transporters), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lactate transmembrane transport, monocarboxylic acid transport, transmembrane transport; MF: monocarboxylic acid transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: apical plasma membrane, basal plasma membrane, basolateral plasma membrane, membrane, plasma membrane
Pathways: Basigin interactions, Cell surface interactions at the vascular wall, Hemostasis, Proton-coupled monocarboxylate transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: O35308
Entrez ID: 57274
|
Does Knockout of Glis2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Glis2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Glis2 (GLIS family zinc finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell differentiation involved in kidney development, central nervous system development, hematopoietic stem cell homeostasis, kidney development, negative regulation of DNA-templated transcription, negative regulation of smoothened signaling pathway, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of DNA-templated transcription, positive regulation of protein localization to nucleus, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: cytoplasm, non-motile cilium, nuclear speck, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q8VDL9
Entrez ID: 83396
|
Does Knockout of Aqp11 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Aqp11
|
phagocytosis
|
macrophage
|
Gene: Aqp11 (aquaporin 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosomal lumen acidification, glycerol transmembrane transport, hydrogen peroxide transmembrane transport, intracellular oxygen homeostasis, intracellular water homeostasis, kidney development, negative regulation of ERAD pathway, negative regulation of epithelial cell proliferation, negative regulation of response to endoplasmic reticulum stress, positive regulation of cell population proliferation, protein glycosylation, protein homooligomerization, protein targeting to membrane, proximal tubule development, transmembrane transport, water transport; MF: channel activity, glycerol channel activity, hydrogen peroxide channel activity, identical protein binding, water channel activity; CC: cell surface, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Aquaporin-mediated transport, Passive transport by Aquaporins, Transport of small molecules
UniProt: Q8BHH1
Entrez ID: 66333
|
Does Knockout of Gm17330 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Gm17330
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gm17330 (predicted gene, 17330)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Jund in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Jund
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Jund (jun D proto-oncogene)
Type: protein-coding
Summary: The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013].
Gene Ontology: BP: cellular response to calcium ion, cellular response to fatty acid, cellular response to hypoxia, circadian rhythm, gene expression, negative regulation of transcription by RNA polymerase II, osteoblast development, positive regulation of macrophage activation, positive regulation of osteoblast differentiation, positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell population proliferation, response to forskolin, response to light stimulus, response to lipopolysaccharide, response to mechanical stimulus, response to peptide hormone, response to steroid hormone, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, enzyme binding, nuclear receptor binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coactivator activity, transcription coregulator binding; CC: RNA polymerase II transcription regulator complex, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, transcription factor AP-1 complex, transcription regulator complex, transcription repressor complex
Pathways: IL-17 signaling pathway - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse)
UniProt: P15066
Entrez ID: 16478
|
Does Knockout of Ormdl3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Ormdl3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ormdl3 (ORM1-like 3 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide metabolic process, intracellular sphingolipid homeostasis, motor behavior, myelination, negative regulation of B cell apoptotic process, negative regulation of ceramide biosynthetic process, positive regulation of autophagy, positive regulation of protein localization to nucleus, regulation of ceramide biosynthetic process, regulation of smooth muscle contraction, regulation of sphingolipid biosynthetic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingomyelin biosynthetic process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Immune System, Innate Immune System, Metabolism, Metabolism of lipids, Neutrophil degranulation, Sphingolipid de novo biosynthesis, Sphingolipid metabolism
UniProt: Q9CPZ6
Entrez ID: 66612
|
Does Knockout of D630033O11Rik in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
D630033O11Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: D630033O11Rik (RIKEN cDNA D630033O11 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Imp4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Imp4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Imp4 (IMP4, U3 small nucleolar ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: rRNA binding, rRNA primary transcript binding, snoRNA binding; CC: Mpp10 complex, fibrillar center, nucleolus, nucleoplasm, nucleus, preribosome, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8VHZ7
Entrez ID: 27993
|
Does Knockout of Islr2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Islr2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Islr2 (immunoglobulin superfamily containing leucine-rich repeat 2)
Type: protein-coding
Summary: Involved in positive regulation of axon extension. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: nervous system development, positive regulation of axon extension; CC: cell surface, membrane, plasma membrane
Pathways:
UniProt: Q5RKR3
Entrez ID: 320563
|
Does Knockout of Selenbp2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Selenbp2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Selenbp2 (selenium binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: methanethiol oxidase activity, selenium binding; CC: cytoplasm, cytosol, fibrillar center, membrane, nucleolus, nucleus
Pathways: Sulfur metabolism - Mus musculus (mouse)
UniProt: Q63836
Entrez ID: 20342
|
Does Knockout of Tecr in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Tecr
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tecr (trans-2,3-enoyl-CoA reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid elongation, fatty acid metabolic process, lipid metabolic process, sphingolipid metabolic process, steroid biosynthetic process, very long-chain fatty acid biosynthetic process; MF: oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, very-long-chain enoyl-CoA reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs
UniProt: Q9CY27
Entrez ID: 106529
|
Does Knockout of Marcks in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Marcks
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Marcks (myristoylated alanine rich protein kinase C substrate)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin crosslink formation, actin filament bundle assembly, actin filament organization, apoptotic process, cell-substrate adhesion, central nervous system development, intracellular protein transport, mitochondrion organization, neural tube development, neurogenesis, positive regulation of dendritic spine morphogenesis, positive regulation of insulin receptor signaling pathway, positive regulation of neuron projection development, regulation of modification of postsynaptic actin cytoskeleton, response to endoplasmic reticulum stress; MF: actin binding, actin filament binding, calmodulin binding, identical protein binding, phosphatidylserine binding, phospholipid binding, protein kinase C binding; CC: actin filament bundle, axon terminus, bleb, cell cortex, cell junction, centrosome, chromatoid body, cilium, cytoplasm, cytoskeleton, cytosol, dendritic branch, dendritic spine, endoplasmic reticulum, germinal vesicle, glutamatergic synapse, growth cone, membrane, microtubule, nuclear speck, nucleoplasm, organelle, outer dense fiber, plasma membrane, postsynaptic cytoskeleton, postsynaptic membrane, presynaptic cytosol, presynaptic membrane
Pathways: Acetylcholine regulates insulin secretion, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Integration of energy metabolism, Metabolism, MicroRNAs in cancer - Mus musculus (mouse), Regulation of insulin secretion
UniProt: P26645
Entrez ID: 17118
|
Does Knockout of Alg11 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Alg11
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Alg11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation; MF: GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity, glycosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: N-Glycan biosynthesis - Mus musculus (mouse), Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q3TZM9
Entrez ID: 207958
|
Does Knockout of Serpine1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Serpine1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Serpine1 (serine (or cysteine) peptidase inhibitor, clade E, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to transforming growth factor beta stimulus, cellular response to xenobiotic stimulus, defense response to Gram-negative bacterium, dentinogenesis, female gonad development, negative regulation of blood coagulation, negative regulation of cell adhesion mediated by integrin, negative regulation of cell migration, negative regulation of endothelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of fibrinolysis, negative regulation of gene expression, negative regulation of integrin-mediated signaling pathway, negative regulation of plasminogen activation, negative regulation of proteolysis, negative regulation of smooth muscle cell migration, negative regulation of smooth muscle cell-matrix adhesion, negative regulation of thrombin-activated receptor signaling pathway, negative regulation of vascular wound healing, negative regulation of wound healing, placenta development, positive regulation of angiogenesis, positive regulation of blood coagulation, positive regulation of calcium ion import, positive regulation of coagulation, positive regulation of collagen biosynthetic process, positive regulation of epithelium regeneration, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of inflammatory response, positive regulation of interleukin-8 production, positive regulation of keratinocyte migration, positive regulation of leukotriene production involved in inflammatory response, positive regulation of monocyte chemotaxis, positive regulation of odontoblast differentiation, positive regulation of receptor-mediated endocytosis, regulation of angiogenesis, regulation of cell population proliferation, replicative senescence, response to bacterium; MF: endopeptidase inhibitor activity, peptidase inhibitor activity, protease binding, protein binding, serine-type endopeptidase inhibitor activity, signaling receptor binding; CC: chromaffin granule, extracellular exosome, extracellular matrix, extracellular region, extracellular space, peptidase inhibitor complex, serine protease inhibitor complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Complement and coagulation cascades - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: G5E899
Entrez ID: 18787
|
Does Knockout of Pira2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Pira2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pira2 (paired-Ig-like receptor A2)
Type: protein-coding
Summary: Predicted to enable several functions, including IgM binding activity; coreceptor activity; and inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be part of Fc-epsilon receptor I complex. Predicted to be active in plasma membrane. Orthologous to several human genes including LILRA4 (leukocyte immunoglobulin like receptor A4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell surface receptor signaling pathway, cytokine-mediated signaling pathway, immune response-regulating signaling pathway; MF: IgM binding, coreceptor activity, inhibitory MHC class I receptor activity, signaling receptor binding; CC: Fc-epsilon receptor I complex, plasma membrane
Pathways: B cell receptor signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation, Osteoclast differentiation - Mus musculus (mouse)
UniProt: D3Z3W9, F8VQ94
Entrez ID: 18725
|
Does Knockout of Ccbe1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Ccbe1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ccbe1 (collagen and calcium binding EGF domains 1)
Type: protein-coding
Summary: Predicted to enable collagen binding activity and protease binding activity. Involved in positive regulation of angiogenesis and positive regulation of lymphangiogenesis. Acts upstream of or within several processes, including lymphangiogenesis; positive regulation of endothelial cell migration; and respiratory system process. Predicted to be located in extracellular matrix and extracellular space. Predicted to be part of collagen trimer. Is expressed in several structures, including anterior cardinal vein; branchial arch; embryo mesenchyme; heart; and intraembryonic coelom. Human ortholog(s) of this gene implicated in Hennekam syndrome. Orthologous to human CCBE1 (collagen and calcium binding EGF domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: angiogenesis, lung development, lymph vessel development, lymphangiogenesis, lymphatic endothelial cell migration, positive regulation of angiogenesis, positive regulation of endothelial cell migration, positive regulation of lymphangiogenesis, positive regulation of protein processing, positive regulation of vascular endothelial growth factor production, positive regulation of vascular endothelial growth factor signaling pathway, respiratory gaseous exchange by respiratory system, respiratory system process, sprouting angiogenesis, venous blood vessel morphogenesis; MF: calcium ion binding, collagen binding, protease binding; CC: collagen trimer, extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: Q3MI99
Entrez ID: 320924
|
Does Knockout of Slx4 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Slx4
|
response to virus
|
Microglial Cell Line
|
Gene: Slx4 (SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae))
Type: protein-coding
Summary: This gene encodes a protein containing a BTB (POZ) domain that comprises a subunit of structure-specific endonucleases. The encoded protein aids in the resolution of DNA secondary structures that arise during the processes of DNA repair and recombination. Knock out of this gene in mouse recapitulates the phenotype of the human disease Fanconi anemia, including blood cytopenia and susceptibility to genomic instability. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: DNA damage response, DNA double-strand break processing involved in repair via single-strand annealing, DNA recombination, DNA repair, DNA replication, double-strand break repair via homologous recombination, negative regulation of telomere maintenance via telomere lengthening, nucleotide-excision repair, positive regulation of t-circle formation, positive regulation of telomere maintenance, resolution of meiotic recombination intermediates, response to intra-S DNA damage checkpoint signaling, t-circle formation, telomeric D-loop disassembly; MF: DNA binding, enzyme activator activity, metal ion binding, zinc ion binding; CC: ERCC4-ERCC1 complex, Holliday junction resolvase complex, Slx1-Slx4 complex, chromatin, chromosome, telomeric region, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q6P1D7
Entrez ID: 52864
|
Does Knockout of Shroom1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Shroom1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Shroom1 (shroom family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle assembly, cell morphogenesis; MF: actin binding, actin filament binding, myosin II binding; CC: adherens junction, apical junction complex, apical plasma membrane, cortical actin cytoskeleton, cytoplasm, cytoskeleton, microtubule
Pathways:
UniProt: Q5SX79
Entrez ID: 71774
|
Does Knockout of Fxr2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 163
|
Knockout
|
Fxr2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fxr2 (FMR1 autosomal homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, dentate gyrus development, mRNA destabilization, mRNA transport, negative regulation of gene expression, positive regulation of long-term neuronal synaptic plasticity, positive regulation of translation, post-transcriptional regulation of gene expression, regulation of mRNA stability, regulation of translation, regulation of translation at presynapse, modulating synaptic transmission; MF: RNA binding, identical protein binding, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding, protein binding, protein heterodimerization activity, protein homodimerization activity, translation regulator activity; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, dendrite, glutamatergic synapse, neuron projection, nucleus, postsynapse, presynapse, ribosome, synapse
Pathways:
UniProt: A0A991EKZ2, Q6P5B5
Entrez ID: 23879
|
Does Knockout of Ccdc183 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Ccdc183
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ccdc183 (coiled-coil domain containing 183)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2AJB1
Entrez ID: 77058
|
Does Knockout of Gclm in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Gclm
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gclm (glutamate-cysteine ligase, modifier subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic mitochondrial changes, blood vessel diameter maintenance, cellular response to fibroblast growth factor stimulus, cellular response to follicle-stimulating hormone stimulus, cellular response to glucose stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to leukemia inhibitory factor, cellular response to thyroxine stimulus, cysteine metabolic process, glutamate metabolic process, glutathione biosynthetic process, glutathione metabolic process, hepatic stellate cell activation, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of neuron apoptotic process, regulation of mitochondrial depolarization, response to activity, response to human chorionic gonadotropin, response to nitrosative stress, response to nutrient, response to oxidative stress, response to xenobiotic stimulus; MF: glutamate-cysteine ligase activity, glutamate-cysteine ligase catalytic subunit binding, glutamate-cysteine ligase regulator activity, protein binding, protein-containing complex binding; CC: glutamate-cysteine ligase complex
Pathways: γ-glutamyl cycle, Biological oxidations, Cysteine and methionine metabolism - Mus musculus (mouse), Ferroptosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Glutathione synthesis and recycling, Metabolism, Phase II - Conjugation of compounds, glutathione biosynthesis
UniProt: O09172
Entrez ID: 14630
|
Does Knockout of Pla2g10 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Pla2g10
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pla2g10 (phospholipase A2, group X)
Type: protein-coding
Summary: This gene encodes a member of the phospholipase A2 family of lipolytic enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate a calcium-dependent enzyme that plays pivotal roles in the liberation of arachidonic acid from membrane phospholipids leading to the production of various inflammatory lipid mediators, such as prostaglandins. In response to myocardial ischemia/reperfusion, mice lacking the encoded protein display a reduction in myocardial infarct size partly through the suppression of neutorphil cytotoxic activities. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: arachidonate secretion, axon guidance, cellular response to leukemia inhibitory factor, cholesterol homeostasis, defense response to virus, erythrocyte maturation, fertilization, hair follicle morphogenesis, intestinal stem cell homeostasis, lipid catabolic process, lipid metabolic process, low-density lipoprotein particle remodeling, lysophospholipid transport, macrophage activation, negative regulation of cholesterol efflux, negative regulation of cytokine production involved in inflammatory response, negative regulation of inflammatory response, negative regulation of transcription by RNA polymerase II, nuclear receptor-mediated signaling pathway, phosphatidic acid metabolic process, phosphatidylcholine catabolic process, phosphatidylcholine metabolic process, phosphatidylethanolamine metabolic process, phosphatidylglycerol metabolic process, phosphatidylserine metabolic process, phospholipid metabolic process, platelet activating factor catabolic process, positive regulation of acrosome reaction, positive regulation of arachidonate secretion, positive regulation of lipid storage, positive regulation of prostaglandin secretion, positive regulation of protein metabolic process, production of molecular mediator involved in inflammatory response, prostaglandin biosynthetic process, regulation of macrophage activation, signal transduction involved in regulation of gene expression; MF: 1-alkyl-2-acetylglycerophosphocholine esterase activity, calcium ion binding, calcium-dependent phospholipase A2 activity, hydrolase activity, metal ion binding, phospholipase A2 activity, phospholipase activity, phospholipid binding; CC: acrosomal vesicle, cytoplasmic vesicle, extracellular region, extracellular space, lysosome
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PG, Acyl chain remodelling of PI, Acyl chain remodelling of PS, Arachidonic acid metabolism - Mus musculus (mouse), Ether lipid metabolism - Mus musculus (mouse), Fat digestion and absorption - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Pancreatic secretion - Mus musculus (mouse), Phospholipid metabolism, Ras signaling pathway - Mus musculus (mouse), Synthesis of PA, Vascular smooth muscle contraction - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), phospholipases
UniProt: Q9QXX3
Entrez ID: 26565
|
Does Knockout of Zfp773 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Zfp773
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp773 (zinc finger protein 773)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q149T8, Q9CZ29, Q3V3V8, A0A1B0GRS1
Entrez ID: 76373
|
Does Knockout of Heph in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Heph
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Heph (hephaestin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intestinal iron absorption, iron ion transport, monoatomic ion transport, multicellular organismal-level iron ion homeostasis, positive regulation of iron export across plasma membrane; MF: copper ion binding, ferroxidase activity, metal ion binding, oxidoreductase activity; CC: basolateral plasma membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Iron uptake and transport, Metal ion SLC transporters, Mineral absorption - Mus musculus (mouse), Porphyrin and chlorophyll metabolism - Mus musculus (mouse), SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q9Z0Z4
Entrez ID: 15203
|
Does Knockout of Mon2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Mon2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mon2 (MON2 homolog, regulator of endosome to Golgi trafficking)
Type: protein-coding
Summary: Predicted to be involved in Golgi to endosome transport. Predicted to be located in early endosome membrane. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: Golgi to endosome transport, protein transport; CC: cytosol, early endosome membrane, endosome, membrane
Pathways:
UniProt: Q80TL7
Entrez ID: 67074
|
Does Knockout of Csrp3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Csrp3
|
cell cycle progression
|
breast epithelium
|
Gene: Csrp3 (cysteine and glycine-rich protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-tubule organization, cardiac muscle contraction, cardiac muscle hypertrophy, cardiac muscle tissue development, cardiac myofibril assembly, cell differentiation, detection of muscle stretch, establishment of protein localization to organelle, glucose homeostasis, heart development, inflammatory response, insulin receptor signaling pathway, intracellular calcium ion homeostasis, muscle cell cellular homeostasis, muscle organ development, muscle tissue development, negative regulation of actin filament severing, negative regulation of myoblast differentiation, phospholipase C/protein kinase C signal transduction, positive regulation of actin filament severing, positive regulation of myoblast differentiation, positive regulation of myotube differentiation, positive regulation of transcription by RNA polymerase II, regulation of protein localization to plasma membrane, regulation of the force of heart contraction, sarcomere organization; MF: MRF binding, RNA polymerase II-specific DNA-binding transcription factor binding, actin binding, actinin binding, identical protein binding, metal ion binding, protein binding, structural constituent of muscle, telethonin binding; CC: Z disc, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, sarcomere
Pathways:
UniProt: P50462
Entrez ID: 13009
|
Does Knockout of Dpy19l3 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Dpy19l3
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Dpy19l3 (dpy-19 like C-mannosyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q71B07
Entrez ID: 233115
|
Does Knockout of Cacna1g in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Cacna1g
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cacna1g (calcium channel, voltage-dependent, T type, alpha 1G subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, artery smooth muscle contraction, calcium ion import, calcium ion transmembrane transport, calcium ion transport, calcium ion transport into cytosol, chemical synaptic transmission, membrane depolarization during action potential, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of calcium ion-dependent exocytosis, positive regulation of cytosolic calcium ion concentration, regulation of atrial cardiac muscle cell membrane depolarization, regulation of biological quality, regulation of calcium ion transport, regulation of heart rate, regulation of membrane potential, response to nickel cation, sodium ion transmembrane transport, system process, transmembrane transport; MF: calcium channel activity, low voltage-gated calcium channel activity, metal ion binding, monoatomic ion channel activity, protein binding, scaffold protein binding, voltage-gated calcium channel activity, voltage-gated sodium channel activity; CC: cell body, cytoplasm, dendrite, membrane, monoatomic ion channel complex, neuron projection, neuronal cell body, perinuclear region of cytoplasm, plasma membrane, synapse, voltage-gated calcium channel complex, voltage-gated sodium channel complex
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse)
UniProt: Q5SUF5, Q5SUG0, Q5SUF6, Q5SUG4, Q5SUG3, Q6PFV8, E9PWL1, Q27YN9, Q6ZPX4, Q9WUT2, Q5SUG1, Q5SUF8, Q5SUF9, Q5SUF7, Q5SUG2
Entrez ID: 12291
|
Does Knockout of Mucl1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mucl1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mucl1 (mucin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q62265
Entrez ID: 20771
|
Does Knockout of Ifi27 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ifi27
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ifi27 (interferon, alpha-inducible protein 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intrinsic apoptotic signaling pathway, negative regulation of transcription by RNA polymerase II, regulation of protein export from nucleus; MF: RNA polymerase II-specific DNA-binding transcription factor binding, identical protein binding, lamin binding, molecular adaptor activity; CC: membrane, mitochondrial membrane, mitochondrion, nuclear envelope, nuclear inner membrane
Pathways:
UniProt: Q9D1E1, Q70LN0, Q70LM9, Q8C6G0, E9Q1C5, D3Z4L8
Entrez ID: 52668
|
Does Knockout of Hdhd5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Hdhd5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hdhd5 (haloacid dehalogenase like hydrolase domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: Q91WM2
Entrez ID: 214932
|
Does Knockout of Lpcat1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Lpcat1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Lpcat1 (lysophosphatidylcholine acyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycerolipid metabolic process, lipid metabolic process, negative regulation of phosphatidylcholine biosynthetic process, phosphatidylcholine acyl-chain remodeling, phospholipid biosynthetic process, phospholipid metabolic process, positive regulation of protein catabolic process, retina development in camera-type eye, surfactant homeostasis; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, 1-acylglycerophosphocholine O-acyltransferase activity, 1-alkylglycerophosphocholine O-acetyltransferase activity, 1-alkylglycerophosphocholine O-acyltransferase activity, O-acyltransferase activity, acyltransferase activity, calcium ion binding, lysophosphatidic acid acyltransferase activity, metal ion binding, plasmalogen synthase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane, plasma membrane
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PG, Ether lipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of lipids, Neutrophil degranulation, Phospholipid metabolism, Synthesis of PA, Synthesis of PC
UniProt: Q3TFD2
Entrez ID: 210992
|
Does Knockout of Syne3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Syne3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Syne3 (spectrin repeat containing, nuclear envelope family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, establishment of protein localization to membrane, nuclear migration, regulation of cell shape; MF: actin filament binding, cytoskeleton-nuclear membrane anchor activity, protein binding; CC: cytoplasm, endoplasmic reticulum, meiotic nuclear membrane microtubule tethering complex, membrane, nuclear envelope, nuclear membrane, nuclear outer membrane, nucleus, rough endoplasmic reticulum
Pathways:
UniProt: Q4FZC9
Entrez ID: 212073
|
Does Knockout of Stkld1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Stkld1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Stkld1 (serine/threonine kinase-like domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity
Pathways:
UniProt: Q80YS9
Entrez ID: 279029
|
Does Knockout of Lilra6 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Lilra6
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Lilra6 (leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, cytokine-mediated signaling pathway, immune response-regulating signaling pathway; MF: IgM binding, coreceptor activity, inhibitory MHC class I receptor activity, signaling receptor binding; CC: Fc-epsilon receptor I complex, plasma membrane
Pathways: B cell receptor signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation, Osteoclast differentiation - Mus musculus (mouse)
UniProt: E9Q6M9, A0A0B4J1F3, A0A0U1RP96
Entrez ID: 18726
|
Does Knockout of Tmco3 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,411
|
Knockout
|
Tmco3
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Tmco3 (transmembrane and coiled-coil domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, monoatomic cation transport, monoatomic ion transport, potassium ion transmembrane transport, proton transmembrane transport, transmembrane transport; MF: antiporter activity, molecular_function, potassium:proton antiporter activity
Pathways:
UniProt: Q8BH01
Entrez ID: 234076
|
Does Knockout of Adam8 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Adam8
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Adam8 (a disintegrin and metallopeptidase domain 8)
Type: protein-coding
Summary: This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: angiogenesis, blood vessel endothelial cell migration, canonical NF-kappaB signal transduction, cell morphogenesis, cell-cell adhesion, cell-matrix adhesion, cellular response to hypoxia, inflammatory response, leukocyte migration involved in inflammatory response, lymphocyte chemotaxis, membrane fusion, negative regulation of neuron apoptotic process, negative regulation of thymocyte aggregation, osteoclast fusion, positive regulation of MAPK cascade, positive regulation of T cell differentiation in thymus, positive regulation of T cell migration, positive regulation of acute inflammatory response, positive regulation of bone resorption, positive regulation of cell adhesion, positive regulation of cellular extravasation, positive regulation of eosinophil migration, positive regulation of epithelial to mesenchymal transition, positive regulation of fibronectin-dependent thymocyte migration, positive regulation of inflammatory response, positive regulation of innate immune response, positive regulation of membrane protein ectodomain proteolysis, positive regulation of neutrophil extravasation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of thymocyte apoptotic process, positive regulation of tumor necrosis factor (ligand) superfamily member 11 production, proteolysis, regulation of cell-cell adhesion, regulation of osteoclast differentiation, signal release, tissue morphogenesis; MF: calcium ion binding, cell adhesion molecule binding, hydrolase activity, immunoglobulin receptor binding, integrin binding, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein binding, tumor necrosis factor receptor superfamily binding, zinc ion binding; CC: alpha9-beta1 integrin-ADAM8 complex, cell surface, cytoplasm, dense core granule membrane, membrane, phagolysosome, plasma membrane, podosome, specific granule, tertiary granule
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization, Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q05910
Entrez ID: 11501
|
Does Knockout of Emp2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Emp2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Emp2 (epithelial membrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell mediated cytotoxicity, actin filament organization, actin-mediated cell contraction, apoptotic process, bleb assembly, blood vessel endothelial cell migration, caveola assembly, cell adhesion, cell-matrix adhesion, early endosome to late endosome transport, embryo implantation, embryonic process involved in female pregnancy, heart formation, membrane raft assembly, natural killer cell proliferation, neutrophil migration, plasma membrane raft assembly, positive regulation of angiogenesis, positive regulation of cardiac epithelial to mesenchymal transition, positive regulation of cell population proliferation, positive regulation of cell-matrix adhesion, positive regulation of integrin-mediated signaling pathway, protein localization to cell surface, protein localization to plasma membrane, regulation of angiogenesis, regulation of cell-matrix adhesion, regulation of endothelial cell migration, regulation of glomerular filtration, regulation of kinase activity, regulation of vasculogenesis; MF: integrin binding, kinase binding; CC: Golgi apparatus, Golgi membrane, apical part of cell, apical plasma membrane, caveola, cell surface, cytoplasm, cytoplasmic vesicle, membrane, membrane raft, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: O88662
Entrez ID: 13731
|
Does Knockout of App in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
App
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: App (amyloid beta precursor protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Notch signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adult locomotory behavior, amyloid fibril formation, antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, apoptotic process, associative learning, astrocyte activation, astrocyte activation involved in immune response, axo-dendritic transport, axon midline choice point recognition, axonogenesis, calcium ion transport, calcium-mediated signaling, cell adhesion, cellular response to amyloid-beta, cellular response to norepinephrine stimulus, central nervous system development, central nervous system neuron differentiation, cholesterol metabolic process, cognition, collateral sprouting in absence of injury, cytosolic mRNA polyadenylation, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, dendrite development, endocytosis, extracellular matrix organization, forebrain development, gene expression, hippocampal neuron apoptotic process, innate immune response, intracellular copper ion homeostasis, ionotropic glutamate receptor signaling pathway, learning, learning or memory, locomotory behavior, long-term synaptic potentiation, low-density lipoprotein particle mediated signaling, mating behavior, memory, microglia development, microglial cell activation, modulation of excitatory postsynaptic potential, negative regulation of blood circulation, negative regulation of canonical Wnt signaling pathway, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of long-term synaptic potentiation, negative regulation of miRNA transcription, negative regulation of neuron differentiation, negative regulation of presynapse assembly, negative regulation of protein localization to nucleus, negative regulation of transcription by RNA polymerase II, neuromuscular process controlling balance, neuron apoptotic process, neuron cellular homeostasis, neuron projection development, neuron projection maintenance, neuron remodeling, phospholipase D-activating G protein-coupled receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of G protein-coupled receptor internalization, positive regulation of G protein-coupled receptor signaling pathway, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of T cell migration, positive regulation of Toll signaling pathway, positive regulation of amyloid fibril formation, positive regulation of amyloid precursor protein catabolic process, positive regulation of apoptotic process, positive regulation of cAMP/PKA signal transduction, positive regulation of calcium-mediated signaling, positive regulation of chemokine production, positive regulation of endothelin production, positive regulation of excitatory postsynaptic potential, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of gene expression, positive regulation of gene expression, epigenetic, positive regulation of glycolytic process, positive regulation of inflammatory response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of long-term synaptic potentiation, positive regulation of macromolecule metabolic process, positive regulation of membrane protein ectodomain proteolysis, positive regulation of mitotic cell cycle, positive regulation of monocyte chemotaxis, positive regulation of neuron apoptotic process, positive regulation of neuron differentiation, positive regulation of nitric oxide biosynthetic process, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of protein import, positive regulation of protein metabolic process, positive regulation of response to endoplasmic reticulum stress, positive regulation of superoxide anion generation, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, protein homooligomerization, protein tetramerization, protein trimerization, regulation of amyloid fibril formation, regulation of amyloid-beta clearance, regulation of dendritic spine maintenance, regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, regulation of gene expression, regulation of long-term neuronal synaptic plasticity, regulation of multicellular organism growth, regulation of neurotransmitter uptake, regulation of presynapse assembly, regulation of protein metabolic process, regulation of response to calcium ion, regulation of spontaneous synaptic transmission, regulation of synapse structure or activity, regulation of toll-like receptor signaling pathway, regulation of transcription by RNA polymerase II, regulation of translation, response to interleukin-1, response to oxidative stress, response to yeast, smooth endoplasmic reticulum calcium ion homeostasis, suckling behavior, synapse organization, synaptic assembly at neuromuscular junction, visual learning; MF: G protein-coupled receptor binding, PTB domain binding, RAGE receptor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, acetylcholine receptor binding, apolipoprotein binding, chemoattractant activity, chromatin binding, enzyme binding, ephrin receptor binding, frizzled binding, growth factor receptor binding, heparan sulfate proteoglycan binding, heparin binding, identical protein binding, insulin receptor binding, integrin binding, low-density lipoprotein particle receptor binding, metal ion binding, molecular function activator activity, peptidase activator activity, peptidase inhibitor activity, protein binding, protein domain specific binding, protein heterodimerization activity, protein homodimerization activity, protein kinase binding, protein serine/threonine kinase binding, protein-folding chaperone binding, receptor ligand activity, serine-type endopeptidase inhibitor activity, signaling receptor activator activity, signaling receptor binding, transition metal ion binding; CC: COPII-coated ER to Golgi transport vesicle, Golgi apparatus, Golgi-associated vesicle, amyloid-beta complex, apical part of cell, astrocyte projection, axon, cell body, cell projection, cell surface, cell-cell junction, ciliary rootlet, clathrin-coated pit, cytoplasm, cytoplasmic vesicle, dendrite, early endosome, early endosome membrane, endomembrane system, endoplasmic reticulum, endosome, endosome to plasma membrane transport vesicle, extracellular region, extracellular space, growth cone, growth cone filopodium, growth cone lamellipodium, high-density lipoprotein particle, intermediate-density lipoprotein particle, intracellular vesicle, lipoprotein particle, low-density lipoprotein particle, lysosome, main axon, membrane, membrane raft, mitochondrion, neuromuscular junction, neuron projection, neuronal dense core vesicle, nuclear envelope lumen, nucleus, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynapse, presynapse, presynaptic active zone, protein-containing complex, receptor complex, recycling endosome, secretory vesicle, smooth endoplasmic reticulum, spindle midzone, synaptic vesicle, very-low-density lipoprotein particle
Pathways: Alzheimer disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse)
UniProt: P12023
Entrez ID: 11820
|
Does Knockout of Arhgap9 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Arhgap9
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Arhgap9 (Rho GTPase activating protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity, phosphatidylinositol-3,4,5-trisphosphate binding; CC: cytoplasm, plasma membrane
Pathways: CDC42 GTPase cycle, Immune System, Innate Immune System, Neutrophil degranulation, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, cyclic AMP biosynthesis
UniProt: Q8QZW8, Q1HDU4, Q78T58
Entrez ID: 216445
|
Does Knockout of Cenpq in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Cenpq
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cenpq (centromere protein Q)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, metaphase chromosome alignment, positive regulation of protein localization to kinetochore; CC: actin cytoskeleton, chromosome, chromosome, centromeric region, inner kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CPQ5
Entrez ID: 83815
|
Does Knockout of Eny2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Eny2
|
cell cycle progression
|
breast epithelium
|
Gene: Eny2 (ENY2 transcription and export complex 2 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, mRNA export from nucleus, mRNA transport, negative regulation of insulin secretion involved in cellular response to glucose stimulus, poly(A)+ mRNA export from nucleus, positive regulation of DNA-templated transcription, protein transport, regulation of DNA repair, regulation of RNA splicing, regulation of transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: chromatin binding, transcription coactivator activity; CC: DUBm complex, SAGA complex, mitochondrion, nuclear pore, nuclear pore nuclear basket, nucleoplasm, nucleus, transcription export complex 2, transcription factor TFTC complex
Pathways:
UniProt: Q9JIX0
Entrez ID: 223527
|
Does Knockout of Slc44a3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Slc44a3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc44a3 (solute carrier family 44, member 3)
Type: protein-coding
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in gut and olfactory epithelium. Orthologous to human SLC44A3 (solute carrier family 44 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: organic cation transport, transmembrane transport; MF: organic cation transmembrane transporter activity, transmembrane transporter activity; CC: membrane
Pathways: Choline metabolism in cancer - Mus musculus (mouse), Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, SLC-mediated bile acid transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Synthesis of PC, Transport of small molecules
UniProt: Q921V7
Entrez ID: 213603
|
Does Knockout of Gm20831 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Gm20831
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Gm20831 (predicted gene, 20831)
Type: protein-coding
Summary: predicted gene, 20831
Gene Ontology:
Pathways:
UniProt: Q3TTD8
Entrez ID: 100040223
|
Does Knockout of Sfn in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Sfn
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sfn (stratifin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cAMP/PKA signal transduction, cytolysis in another organism, defense response to bacterium, establishment of protein localization, establishment of skin barrier, intracellular protein localization, intrinsic apoptotic signaling pathway in response to DNA damage, keratinization, keratinocyte development, keratinocyte differentiation, negative regulation of innate immune response, negative regulation of keratinocyte proliferation, negative regulation of protein localization to plasma membrane, negative regulation of stem cell proliferation, negative regulation of transcription by RNA polymerase II, non-canonical inflammasome complex assembly, positive regulation of cell adhesion, positive regulation of cell growth, positive regulation of epidermal cell differentiation, positive regulation of protein export from nucleus, positive regulation of protein localization, protein export from nucleus, regulation of cell cycle, regulation of cell-cell adhesion, regulation of epidermal cell division, regulation of protein localization, release of cytochrome c from mitochondria, signal transduction, skin development; MF: identical protein binding, phosphoprotein binding, phosphoserine residue binding, protein binding, protein kinase binding, protein sequestering activity; CC: cytoplasm, cytosol, extracellular region, nucleus
Pathways: Activation of BAD and translocation to mitochondria , Activation of BH3-only proteins, Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Apoptosis, Cell Cycle, Cell Cycle Checkpoints, Cell cycle - Mus musculus (mouse), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, FOXO-mediated transcription, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, Intrinsic Pathway for Apoptosis, Programmed Cell Death, RHO GTPase Effectors, RHO GTPases activate PKNs, RNA Polymerase II Transcription, Regulation of localization of FOXO transcription factors, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Metabolic Genes, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Transcriptional Regulation by TP53, p53 signaling pathway - Mus musculus (mouse)
UniProt: O70456
Entrez ID: 55948
|
Does Knockout of Defb33 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Defb33
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Defb33 (defensin beta 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response, defense response to bacterium, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q30KN3
Entrez ID: 654453
|
Does Knockout of Ms4a10 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Ms4a10
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ms4a10 (membrane-spanning 4-domains, subfamily A, member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q99N03
Entrez ID: 69826
|
Does Knockout of Trim52 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Trim52
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Trim52 (tripartite motif-containing 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, innate immune response, positive regulation of canonical NF-kappaB signal transduction, protein autoubiquitination, protein ubiquitination; MF: metal ion binding, transcription coactivator activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8CDV4
Entrez ID: 212085
|
Does Knockout of Rhox2h in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Rhox2h
|
cell cycle progression
|
breast epithelium
|
Gene: Rhox2h (reproductive homeobox 2H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: V9GXS0, K7N6P1
Entrez ID: 622301
|
Does Knockout of Sez6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Sez6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sez6 (seizure related gene 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult locomotory behavior, cerebellar Purkinje cell layer development, excitatory postsynaptic potential, negative regulation of dendrite development, positive regulation of dendrite development, regulation of dendrite development, synapse maturation; CC: apical dendrite, cell projection, cytoplasm, dendrite, dendritic shaft, dendritic spine, endoplasmic reticulum, extracellular region, extracellular space, membrane, neuronal cell body, perinuclear region of cytoplasm, plasma membrane, synapse
Pathways:
UniProt: Q7TSK2
Entrez ID: 20370
|
Does Knockout of Nyap1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Nyap1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nyap1 (neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuron projection morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction
Pathways:
UniProt: Q6PFX7
Entrez ID: 243300
|
Does Knockout of Oxsr1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Oxsr1
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Oxsr1 (oxidative-stress responsive 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell volume homeostasis, cellular hyperosmotic response, cellular hypotonic response, cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, chemokine (C-X-C motif) ligand 12 signaling pathway, intracellular signal transduction, negative regulation of potassium ion transmembrane transport, osmosensory signaling pathway, positive regulation of T cell chemotaxis, potassium ion transmembrane transport, protein autophosphorylation, protein phosphorylation, renal sodium ion absorption, response to oxidative stress, response to xenobiotic stimulus, signal transduction; MF: ATP binding, identical protein binding, ion channel regulator activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, potassium channel inhibitor activity, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, transmembrane transporter binding; CC: cytoplasm, cytosol
Pathways:
UniProt: Q6P9R2
Entrez ID: 108737
|
Does Knockout of Ube3b in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Ube3b
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ube3b (ubiquitin protein ligase E3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein polyubiquitination, protein ubiquitination, regulation of postsynapse assembly, ubiquitin-dependent protein catabolic process; MF: transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: glutamatergic synapse, mitochondrion, postsynapse, postsynaptic density, synapse
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9ES34
Entrez ID: 117146
|
Does Knockout of Bbx in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Bbx
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Bbx (bobby sox HMG box containing)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within bone development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and sensory organ. Orthologous to human BBX (BBX high mobility group box domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: bone development, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q8VBW5
Entrez ID: 70508
|
Does Knockout of P2ry1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
P2ry1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: P2ry1 (purinergic receptor P2Y, G-protein coupled 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled adenosine receptor signaling pathway, G protein-coupled purinergic nucleotide receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, blood vessel diameter maintenance, cellular response to purine-containing compound, eating behavior, establishment of localization in cell, glial cell migration, negative regulation of norepinephrine secretion, phospholipase C-activating G protein-coupled receptor signaling pathway, platelet activation, positive regulation of ERK1 and ERK2 cascade, positive regulation of cytosolic calcium ion concentration, positive regulation of hormone secretion, positive regulation of inositol trisphosphate biosynthetic process, positive regulation of monoatomic ion transport, positive regulation of penile erection, positive regulation of transcription by RNA polymerase II, protein localization to plasma membrane, regulation of cell shape, regulation of presynaptic cytosolic calcium ion concentration, regulation of synaptic vesicle exocytosis, relaxation of muscle, response to growth factor, response to mechanical stimulus, signal transduction, signal transduction involved in regulation of gene expression; MF: A1 adenosine receptor binding, ADP binding, ATP binding, G protein-coupled ADP receptor activity, G protein-coupled ATP receptor activity, G protein-coupled purinergic nucleotide receptor activity, G protein-coupled receptor activity, nucleotide binding, protein heterodimerization activity, scaffold protein binding, signaling receptor regulator activity; CC: apical plasma membrane, basolateral plasma membrane, cell body, cilium, dendrite, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic active zone membrane
Pathways: ADP signalling through P2Y purinoceptor 1, Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Hemostasis, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nucleotide-like (purinergic) receptors, P2Y receptors, Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Rap1 signaling pathway - Mus musculus (mouse), Signal Transduction, Signal amplification, Signaling by GPCR, Taste transduction - Mus musculus (mouse)
UniProt: P49650
Entrez ID: 18441
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.