prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Il1rl2 in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Il1rl2 | cell proliferation | Regulatory T cell | Gene: Il1rl2 (interleukin 1 receptor-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, cytokine-mediated signaling pathway, immune system process, inflammatory response, innate immune response, interleukin-1-mediated signalin... |
Does Knockout of Aoc2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Aoc2 | cell proliferation | Melanoma Cell Line | Gene: Aoc2 (amine oxidase copper containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amine metabolic process, catecholamine metabolic process; MF: copper ion binding, metal ion binding, oxidoreductase activity, primary methylamine oxidase activity, quinone bindi... |
Does Knockout of Mipep in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Mipep | protein/peptide distribution | myoblast cell line | Gene: Mipep (mitochondrial intermediate peptidase)
Type: protein-coding
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide metabolic process and protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in heart... |
Does Knockout of Reg4 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Reg4 | protein/peptide accumulation | Mouse cell | Gene: Reg4 (regenerating islet-derived family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, heparin binding, mannan binding, signaling receptor activity; CC: cytoplasm, extracellular region, extracellular space
Pathways: Gastric... |
Does Knockout of Gje1 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Gje1 | protein/peptide accumulation | Regulatory T cell | Gene: Gje1 (gap junction protein, epsilon 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, cell morphogenesis, cell-cell signaling, lens development in camera-type eye, organ growth, transmembrane transport; CC: connexin complex, membrane, plasma mem... |
Does Knockout of Sh3gl2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Sh3gl2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Sh3gl2 (SH3-domain GRB2-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to brain-derived neurotrophic factor stimulus, dendrite extension, endocytosis, lipid tube assembly, membrane bending, membrane tubulation, negative regulation of MAPK ... |
Does Knockout of Tmem130 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Tmem130 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Tmem130 (transmembrane protein 130)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, Golgi membrane, membrane, plasma membrane
Pathways:
UniProt: Q6NXM3
Entrez ID: 243339 |
Does Knockout of Sarnp in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Sarnp | cell proliferation | Regulatory T cell | Gene: Sarnp (SAP domain containing ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, negative regulation of transcription by RNA polymerase II, poly(A)+ mRNA export from nucleus, regulation of translation; MF: DNA... |
Does Knockout of Selenoi in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Selenoi | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Selenoi (selenoprotein I)
Type: protein-coding
Summary: The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethan... |
Does Knockout of Oas1c in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Oas1c | cell proliferation | Embryonic Stem Cell Line | Gene: Oas1c (2'-5' oligoadenylate synthetase 1C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to exogenous dsRNA, cellular response to interferon-alpha, cellular response to interferon-beta, defense response to bacter... |
Does Knockout of Cysltr1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Cysltr1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Cysltr1 (cysteinyl leukotriene receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium ion transport, cell surface receptor signaling pathway, cellular response to hypoxia, chemotaxis, endothelium development... |
Does Knockout of Cd300ld5 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Cd300ld5 | cell proliferation | Melanoma Cell Line | Gene: Cd300ld5 (CD300 molecule like family member D5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, immune system process; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: A2A7W1
Entrez ID: 100043125 |
Does Knockout of Msantd2 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Msantd2 | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Msantd2 (Myb/SANT-like DNA-binding domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6NZR2
Entrez ID: 235184 |
Does Knockout of Sgf29 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Sgf29 | cell cycle progression | breast epithelium | Gene: Sgf29 (SAGA complex associated factor 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of DNA repair, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regula... |
Does Knockout of Ctdp1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Ctdp1 | cell proliferation | Melanoma Cell Line | Gene: Ctdp1 (CTD phosphatase subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, exit from mitosis, host-mediated activation of viral transcription, negative regulation of cell growth involved in cardiac muscle cell development, protein dephosphoryla... |
Does Knockout of Rab3il1 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Rab3il1 | phagocytosis | macrophage | Gene: Rab3il1 (RAB3A interacting protein (rabin3)-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, identical protein binding, kinase binding
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, ... |
Does Knockout of Sdr9c7 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Sdr9c7 | cell proliferation | Regulatory T cell | Gene: Sdr9c7 (4short chain dehydrogenase/reductase family 9C, member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: retinol metabolic process, steroid metabolic process; MF: all-trans-retinol dehydrogenase (NAD+) activity, oxidoreductase activity; CC: cytoplasm, intra... |
Does Knockout of Prkra in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Prkra | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Prkra (protein kinase, interferon inducible double stranded RNA dependent activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RISC complex assembly, antiviral innate immune response, cellular response to oxidative stress, ear development, miRNA processing, mi... |
Does Knockout of Iqcc in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Iqcc | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Iqcc (IQ motif containing C)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2ADZ8
Entrez ID: 230767 |
Does Knockout of Lig4 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Lig4 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Lig4 (ligase IV, DNA, ATP-dependent)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DN2 thymocyte differentiation, DNA biosynthetic process, DNA damage response, DNA recombination, DNA repair, T cell receptor V(D)J recombination, V(D)J recombination, base-excision ... |
Does Knockout of Serpina9 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Serpina9 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Serpina9 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extrace... |
Does Knockout of Pdzk1ip1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Pdzk1ip1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Pdzk1ip1 (PDZK1 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: apical plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q9CQH0
Entrez ID: 67182 |
Does Knockout of Tubb6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Tubb6 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Tubb6 (tubulin, beta 6 class V)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, GTPase activity, metal ion binding, nucleotide binding, structural constituent of c... |
Does Knockout of Eif2ak2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Eif2ak2 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to amino acid starvation, defense response to virus, endoplasmic reticulum unfolded protein respon... |
Does Knockout of Kiss1 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Kiss1 | phagocytosis | macrophage | Gene: Kiss1 (KiSS-1 metastasis-suppressor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, decidualization, generation of ovulation cycle rhythm, negative regulation of cell population proliferation, phospholipase C-activating... |
Does Knockout of Fgr in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Fgr | protein/peptide distribution | myoblast cell line | Gene: Fgr (FGR proto-oncogene, Src family tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, cell differentiation, cell surface receptor protein tyrosine kinase signaling pathway, defense response to Gram-positive bacterium, immune syste... |
Does Knockout of Tdrd1 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Tdrd1 | cell proliferation | Embryonic Stem Cell Line | Gene: Tdrd1 (tudor domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P granule organization, cell differentiation, germ cell development, meiotic cell cycle, piRNA processing, regulatory ncRNA-mediated gene silencing, spermatogenesis, transposable eleme... |
Does Knockout of Trp73 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,180 | Knockout | Trp73 | tumorigenicity | Colonic Cancer Cell Line | Gene: Trp73 (transformation related protein 73)
Type: protein-coding
Summary: This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence si... |
Does Knockout of Epm2a in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,176 | Knockout | Epm2a | cell proliferation | Colonic Cancer Cell Line | Gene: Epm2a (epilepsy, progressive myoclonic epilepsy, type 2 gene alpha)
Type: protein-coding
Summary: Enables several functions, including alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity; phosphatase activity; and starch binding activity. Involved in carbohydrate phosphorylation and ... |
Does Knockout of Dynlt3 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Dynlt3 | response to virus | Embryonic Fibroblast Cell Line | Gene: Dynlt3 (dynein light chain Tctex-type 3)
Type: protein-coding
Summary: Predicted to enable dynein intermediate chain binding activity and identical protein binding activity. Predicted to be involved in microtubule-based movement and positive regulation of mitotic cell cycle. Predicted to be locate... |
Does Knockout of Ell3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Ell3 | protein/peptide distribution | myoblast cell line | Gene: Ell3 (elongation factor RNA polymerase II-like 3)
Type: protein-coding
Summary: Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of epithelial to mesenchymal transiti... |
Does Knockout of Atp13a2 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Atp13a2 | protein/peptide accumulation | Embryonic Cell Line | Gene: Atp13a2 (ATPase type 13A2)
Type: protein-coding
Summary: Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; phospholipid binding activity; and polyamine transmembrane transporter activity. Involved in several processes, including autophagosome-lysosome fusion;... |
Does Knockout of Ifng in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Ifng | cell proliferation | Mouse kidney carcinoma cell | Gene: Ifng (interferon gamma)
Type: protein-coding
Summary: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma... |
Does Knockout of Mtmr4 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Mtmr4 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Mtmr4 (myotubularin related protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: midbody abscission, negative regulation of BMP signaling pathway, negative regulation of endocytic recycling, negative regulation of transforming growth factor beta receptor signa... |
Does Knockout of Pafah1b2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,185 | Knockout | Pafah1b2 | cell proliferation | Melanoma Cell Line | Gene: Pafah1b2 (platelet-activating factor acetylhydrolase, isoform 1b, subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid catabolic process, lipid metabolic process, positive regulation of macroautophagy, spermatogenesis; MF: 1-alkyl-2-acetylglycerophosphoc... |
Does Knockout of Rnf7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Rnf7 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Rnf7 (ring finger protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, apoptotic mitochondrial changes, cGAS/STING signaling pathway, cerebral cortex radially oriented cell migration, def... |
Does Knockout of Enho in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Enho | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Enho (energy homeostasis associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, energy homeostasis, positive regulation of Notch signaling pathway; MF: hormone activity, protein binding; CC: extracellular region, ex... |
Does Knockout of Cspp1 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Cspp1 | protein/peptide accumulation | Melanoma Cell Line | Gene: Cspp1 (centrosome and spindle pole associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell division, positive regulation of cytokinesis; CC: cell projection, centriolar satellite, centrosome, ciliary basal body, cilium, cyto... |
Does Knockout of Bcl6 in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,541 | Knockout | Bcl6 | response to chemicals | Lymphoma Cell Line | Gene: Bcl6 (B cell leukemia/lymphoma 6)
Type: protein-coding
Summary: Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including ... |
Does Knockout of Ndufs8 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Ndufs8 | response to virus | Microglial Cell Line | Gene: Ndufs8 (NADH:ubiquinone oxidoreductase core subunit S8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochon... |
Does Knockout of Sla in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Sla | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Sla (src-like adaptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of MAPK cascade, signal transduction; MF: epidermal growth factor receptor binding, phosphotyrosine residue binding, protein binding; CC: COP9 signalosome, cytoplasm, endosome, nucleop... |
Does Knockout of Usp9y in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Usp9y | cell proliferation | Mouse kidney carcinoma cell | Gene: Usp9y (ubiquitin specific peptidase 9, Y chromosome)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, protein deubiquitination, protein ubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-t... |
Does Knockout of Vmn2r98 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Vmn2r98 | protein/peptide distribution | myoblast cell line | Gene: Vmn2r98 (vomeronasal 2, receptor 98)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: E9PZ5... |
Does Knockout of Acvr1c in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Acvr1c | protein/peptide accumulation | Regulatory T cell | Gene: Acvr1c (activin A receptor, type IC)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SMAD protein signal transduction, activin receptor signaling pathway, apoptotic nuclear changes, apoptotic process, apoptotic signaling pathway, cell communication, cell differentia... |
Does Knockout of Hapln3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Hapln3 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Hapln3 (hyaluronan and proteoglycan link protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, central nervous system development, skeletal system development; CC: extracellular matrix, extracellular region, extracellular space, perineuronal net,... |
Does Knockout of Sfxn2 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Sfxn2 | protein/peptide distribution | myoblast cell line | Gene: Sfxn2 (sideroflexin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, mitochondrial transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, serine import into mitochondrion, transmembrane transport; MF: monoa... |
Does Knockout of A830005F24Rik in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | A830005F24Rik | phagocytosis | macrophage | Gene: A830005F24Rik (RIKEN cDNA A830005F24 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Nucks1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Nucks1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Nucks1 (nuclear casein kinase and cyclin-dependent kinase substrate 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to X-ray, chromatin organization, double-strand break repair via homologous recombination, gluco... |
Does Knockout of F2rl2 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | F2rl2 | protein/peptide distribution | myoblast cell line | Gene: F2rl2 (coagulation factor II thrombin receptor like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, blood coagulation, hemostasis, ligand-gated ion channel signaling pathway, positive regulation of insulin secretion, ... |
Does Knockout of Fxyd3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 1,664 | Knockout | Fxyd3 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Fxyd3 (FXYD domain-containing ion transport regulator 3)
Type: protein-coding
Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino a... |
Does Knockout of Gm1123 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 165 | Knockout | Gm1123 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Gm1123 (predicted gene 1123)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: adherens junction, anchoring junction, basolateral plasma membrane, bicellular tight junction, intercalated disc
Pathways:
UniProt: Q1RME4
Entrez ID: 382097 |
Does Knockout of Adrm1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Adrm1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Adrm1 (adhesion regulating molecule 1 26S proteasome ubiquitin receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Sertoli cell development, adipose tissue development, follicle-stimulating hormone signaling pathway, oogenesis, ovarian follicle development, po... |
Does Knockout of Arhgap17 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | Arhgap17 | protein/peptide distribution | myoblast cell line | Gene: Arhgap17 (Rho GTPase activating protein 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, calcium-ion regulated exocytosis, negative regulation of small GTPase mediated signal transduction, regulation of Rac protein signal transduction... |
Does Knockout of Vmn1r49 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Vmn1r49 | cell proliferation | Mouse kidney carcinoma cell | Gene: Vmn1r49 (vomeronasal 1, receptor 49)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone... |
Does Knockout of Zfas1 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Zfas1 | phagocytosis | macrophage | Gene: Zfas1 (zinc finger, NFX1-type containing 1, antisense RNA 1)
Type: ncRNA
Summary: No summary available.
Gene Ontology: BP: cardiac muscle contraction, mammary gland epithelial cell differentiation, negative regulation of calcium ion transmembrane transport, negative regulation of mammary ... |
Does Knockout of Zfp354c in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Zfp354c | cell proliferation | Melanoma Cell Line | Gene: Zfp354c (zinc finger protein 354C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, negative regulation of sprouting angiogenesis, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transc... |
Does Knockout of Akr1c12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Akr1c12 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Akr1c12 (aldo-keto reductase family 1, member C12)
Type: protein-coding
Summary: Predicted to enable several functions, including ketosteroid monooxygenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Predicted... |
Does Knockout of Prdm2 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Prdm2 | response to virus | Neuroblastoma Cell Line | Gene: Prdm2 (PR domain containing 2, with ZNF domain)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory regio... |
Does Knockout of Pdcl in Melanoma Cell Line causally result in cell proliferation? | 1 | 1,269 | Knockout | Pdcl | cell proliferation | Melanoma Cell Line | Gene: Pdcl (phosducin-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, heterotrimeric G-protein complex assembly, negative regulation of protein refolding, positive regulation of smoothened signaling pathway, protein folding, regulation ... |
Does Knockout of Acer2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Acer2 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Acer2 (alkaline ceramidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, cellular response to xenobiotic stimulus, ceramide catabolic process, ceramide metabolic process, lipid... |
Does Knockout of Ackr1 in Microglial Cell Line causally result in cell proliferation? | 0 | 1,359 | Knockout | Ackr1 | cell proliferation | Microglial Cell Line | Gene: Ackr1 (atypical chemokine receptor 1 (Duffy blood group))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, chemokine-mediated signaling pathway, inflammatory response, regulation of chemokine production, signal transducti... |
Does Knockout of Htr5b in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | Htr5b | protein/peptide distribution | myoblast cell line | Gene: Htr5b (5-hydroxytryptamine (serotonin) receptor 5B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-inhibitin... |
Does Knockout of Tacr2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Tacr2 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Tacr2 (tachykinin receptor 2)
Type: protein-coding
Summary: Predicted to enable substance K receptor activity. Involved in regulation of uterine smooth muscle contraction. Predicted to be located in sperm flagellum and sperm head. Predicted to be active in plasma membrane and sperm midpiece. Is ex... |
Does Knockout of Zfp82 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Zfp82 | protein/peptide accumulation | Mouse cell | Gene: Zfp82 (zinc finger protein 82)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA po... |
Does Knockout of Ceacam1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Ceacam1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Ceacam1 (CEA cell adhesion molecule 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid and bile salt transport, blood vessel development, cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, cell-cell junction organization, cellular re... |
Does Knockout of Vav1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Vav1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Vav1 (vav 1 oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell proliferation, G protein-coupled receptor signaling pathway, T cell activation, T cell costimulation, T cell differentiation, cell migration, cell surface receptor signaling pathway, immune... |
Does Knockout of Tchh in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Tchh | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Tchh (trichohyalin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermediate filament organization; MF: calcium ion binding, metal ion binding, protein-macromolecule adaptor activity, transition metal ion binding
Pathways: Developmental Biology, Formati... |
Does Knockout of 4930596D02Rik in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | 4930596D02Rik | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: 4930596D02Rik (RIKEN cDNA 4930596D02 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways:
UniProt: Q3V0H9
Entrez ID: 239036 |
Does Knockout of Hip1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Hip1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Hip1 (huntingtin interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, apoptotic process, apoptotic signaling pathway, cell differentiation, clathrin coat assembly, endocytosis, positive regulation of epidermal growth fa... |
Does Knockout of Dnm2 in Melanoma Cell Line causally result in tumorigenicity? | 0 | 616 | Knockout | Dnm2 | tumorigenicity | Melanoma Cell Line | Gene: Dnm2 (dynamin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, Golgi to plasma membrane transport, actin filament bundle organization, aorta development, autophagy, cellular response to dopamine, centrosome cycle, corona... |
Does Knockout of Gusb in Melanoma Cell Line causally result in tumorigenicity? | 0 | 2,187 | Knockout | Gusb | tumorigenicity | Melanoma Cell Line | Gene: Gusb (glucuronidase, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, aorta development, articular cartilage development, autophagy, bone development, bone growth, bone morphogenesis, bone resorption, canonical NF-kappaB signal transduction, ca... |
Does Knockout of Rsph1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Rsph1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Rsph1 (radial spoke head 1 homolog (Chlamydomonas))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axoneme assembly, epithelial cilium movement involved in extracellular fluid movement, flagellated sperm motility, mating, meiotic cell cycle, microtubule-based proce... |
Does Knockout of Nell2 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Nell2 | protein/peptide accumulation | Regulatory T cell | Gene: Nell2 (NEL-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: commissural neuron axon guidance, development of secondary female sexual characteristics, fertilization, neurogenesis, neuron cellular homeostasis, positive regulation of hormone secretion, regulatio... |
Does Knockout of Vmn1r174 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Vmn1r174 | response to virus | Microglial Cell Line | Gene: Vmn1r174 (vomeronasal 1 receptor 174)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled recepto... |
Does Knockout of Diaph2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Diaph2 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Diaph2 (diaphanous related formin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament polymerization, axon midline choice point recognition, cell differentiation, ephrin receptor signaling pathway, intracellular protein... |
Does Knockout of Pqbp1 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Pqbp1 | protein/peptide accumulation | Melanoma Cell Line | Gene: Pqbp1 (polyglutamine binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, activation of innate immune response, alternative mRNA splicing, via spliceosome, cellular response to exogenous dsRNA, defense response to virus, immune system pro... |
Does Knockout of Cops5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,268 | Knockout | Cops5 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Cops5 (COP9 signalosome subunit 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exosomal secretion, negative regulation of apoptotic process, positive regulation of DNA-binding transcription factor activity, positive regulation of transcription by RNA polymerase ... |
Does Knockout of Ice1 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 578 | Knockout | Ice1 | cell proliferation | Embryonic Stem Cell Line | Gene: Ice1 (interactor of little elongation complex ELL subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of intracellular protein transport, positive regulation of protein-containing complex assembly, positive regulation of transcription by R... |
Does Knockout of Gm28465 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Gm28465 | cell proliferation | Mouse kidney carcinoma cell | Gene: Gm28465 (predicted gene 28465)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Vmn2r18 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Vmn2r18 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Vmn2r18 (vomeronasal 2, receptor 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B... |
Does Knockout of Mrps22 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Mrps22 | response to virus | Embryonic Fibroblast Cell Line | Gene: Mrps22 (mitochondrial ribosomal protein S22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Path... |
Does Knockout of Cdk7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,565 | Knockout | Cdk7 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Cdk7 (cyclin dependent kinase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II promoter clearance, RNA polymerase II transcription initiation surveillance, cell division, positive regulation of transcription by RN... |
Does Knockout of Ccr10 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Ccr10 | protein/peptide accumulation | Melanoma Cell Line | Gene: Ccr10 (C-C motif chemokine receptor 10)
Type: protein-coding
Summary: Enables C-C chemokine receptor activity. Acts upstream of or within chemotaxis and positive regulation of cytosolic calcium ion concentration. Predicted to be located in cell surface; endoplasmic reticulum; and plasma membrane. ... |
Does Knockout of Anpep in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,178 | Knockout | Anpep | tumorigenicity | Colonic Cancer Cell Line | Gene: Anpep (alanyl aminopeptidase, membrane)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, angiotensin maturation, cell differentiation, peptide catabolic process, protein processing, proteolysis; MF: alanyl aminopeptidase activity, aminopeptidase activit... |
Does Knockout of Nwd2 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,683 | Knockout | Nwd2 | protein/peptide distribution | myoblast cell line | Gene: Nwd2 (NACHT and WD repeat domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, synapse
Pathways:
UniProt: Q6P5U7
Entrez ID: 319807 |
Does Knockout of Pds5a in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Pds5a | protein/peptide distribution | myoblast cell line | Gene: Pds5a (PDS5 cohesin associated factor A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, cell division, embryonic skeletal system morphogenesis, enteric nervous system development, heart morphogenesis, lens development in ca... |
Does Knockout of Mbnl2 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Mbnl2 | cell proliferation | Embryonic Stem Cell Line | Gene: Mbnl2 (muscleblind like splicing factor 2)
Type: protein-coding
Summary: Predicted to enable RNA binding activity and sequence-specific double-stranded DNA binding activity. Acts upstream of or within regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Pre... |
Does Knockout of Slc25a2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Slc25a2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Slc25a2 (solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-arginine transmembrane transport, L-lysine transmembrane transport, L-ornithine transmembrane transport, mitochondrial L-orni... |
Does Knockout of Clk2 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation? | 1 | 2,411 | Knockout | Clk2 | cell proliferation | Cytotoxic T-lymphocyte (CD8+ T cells) | Gene: Clk2 (CDC-like kinase 2)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in negative regulation of gluconeogenesis and protein autophosphorylation. Acts upstream of or within peptidyl-tyrosine phosphorylation and respons... |
Does Knockout of Itpr3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Itpr3 | protein/peptide distribution | myoblast cell line | Gene: Itpr3 (inositol 1,4,5-triphosphate receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium ion homeostasis, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cellular res... |
Does Knockout of Pde6a in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Pde6a | cell cycle progression | breast epithelium | Gene: Pde6a (phosphodiesterase 6A, cGMP-specific, rod, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cAMP/PKA signal transduction, photoreceptor cell maintenance, retina development in camera-type eye, signal transduction, visual perception... |
Does Knockout of Dnajc19 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Dnajc19 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Dnajc19 (DnaJ heat shock protein family (Hsp40) member C19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: genitalia development, protein import into mitochondrial matrix, protein transport, regulation of cardiolipin metabolic process, visual perception; MF: ATPase... |
Does Knockout of Wrap73 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,565 | Knockout | Wrap73 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Wrap73 (WD repeat containing, antisense to Trp73)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, mitotic spindle assembly, positive regulation of non-motile cilium assembly; CC: MWP complex, centrosome, ciliary basal body, cytoplasm, c... |
Does Knockout of Defb38 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Defb38 | cell proliferation | Melanoma Cell Line | Gene: Defb38 (defensin beta 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, innate immune response in mucosa, response to bacteri... |
Does Knockout of Slc25a18 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Slc25a18 | cell proliferation | Mouse kidney carcinoma cell | Gene: Slc25a18 (solute carrier family 25 (mitochondrial carrier), member 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-aspartate transmembrane transport, L-glutamate transmembrane transport, aspartate transmembrane transport, malate-aspartate shuttle, proton trans... |
Does Knockout of Ccdc187 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Ccdc187 | cell proliferation | Embryonic Stem Cell Line | Gene: Ccdc187 (coiled-coil domain containing 187)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, microtubule anchoring; MF: microtubule binding, molecular_function
Pathways:
UniProt: Q8C5V8
Entrez ID: 329366 |
Does Knockout of Hibadh in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Hibadh | protein/peptide accumulation | Microglial Cell Line | Gene: Hibadh (3-hydroxyisobutyrate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-valine catabolic process, branched-chain amino acid catabolic process; MF: 3-hydroxyisobutyrate dehydrogenase activity, NAD binding, NADP binding, oxidoreductase activity; ... |
Does Knockout of Tmem52b in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Tmem52b | protein/peptide distribution | Microglial Cell Line | Gene: Tmem52b (transmembrane protein 52B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q0VBF2
Entrez ID: 330428 |
Does Knockout of Bfar in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Bfar | cell proliferation | Melanoma Cell Line | Gene: Bfar (bifunctional apoptosis regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRE1-mediated unfolded protein response, apoptotic process, negative regulation of IRE1-mediated unfolded protein response, negative regulation of apoptotic process, proteasome-m... |
Does Knockout of Cnnm1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Cnnm1 | cell proliferation | Colonic Cancer Cell Line | Gene: Cnnm1 (cyclin M1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: magnesium ion homeostasis, monoatomic ion transport, transmembrane transport; CC: dendrite, membrane, neuronal cell body, plasma membrane
Pathways:
UniProt: Q0GA42
Entrez ID... |
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