prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Il1rl2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Il1rl2
|
cell proliferation
|
Regulatory T cell
|
Gene: Il1rl2 (interleukin 1 receptor-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, cytokine-mediated signaling pathway, immune system process, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, positive regulation of T cell differentiation, positive regulation of interleukin-6 production, regulation of inflammatory response, signal transduction; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, cytokine receptor activity, hydrolase activity, interleukin-1 receptor activity, interleukin-1, type I, activating receptor activity; CC: cell surface, cellular_component, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-1 family signaling, Interleukin-36 pathway, Interleukin-38 signaling, Signaling by Interleukins
UniProt: Q9ERS7
Entrez ID: 107527
|
Does Knockout of Aoc2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Aoc2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Aoc2 (amine oxidase copper containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amine metabolic process, catecholamine metabolic process; MF: copper ion binding, metal ion binding, oxidoreductase activity, primary methylamine oxidase activity, quinone binding; CC: cytoplasm, membrane, plasma membrane
Pathways: β-alanine biosynthesis I, Biological oxidations, Glycine, serine and threonine metabolism - Mus musculus (mouse), Metabolism, Phase I - Functionalization of compounds, Phenylalanine metabolism - Mus musculus (mouse), Tyrosine metabolism - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse)
UniProt: Q812C9
Entrez ID: 237940
|
Does Knockout of Mipep in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Mipep
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mipep (mitochondrial intermediate peptidase)
Type: protein-coding
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide metabolic process and protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in heart and tibialis anterior. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 31. Orthologous to human MIPEP (mitochondrial intermediate peptidase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: peptide metabolic process, protein processing involved in protein targeting to mitochondrion, proteolysis; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: A6H611
Entrez ID: 70478
|
Does Knockout of Reg4 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Reg4
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Reg4 (regenerating islet-derived family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, heparin binding, mannan binding, signaling receptor activity; CC: cytoplasm, extracellular region, extracellular space
Pathways: Gastric cancer - Mus musculus (mouse)
UniProt: Q9D8G5
Entrez ID: 67709
|
Does Knockout of Gje1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Gje1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Gje1 (gap junction protein, epsilon 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, cell morphogenesis, cell-cell signaling, lens development in camera-type eye, organ growth, transmembrane transport; CC: connexin complex, membrane, plasma membrane
Pathways:
UniProt: Q9CX92
Entrez ID: 76743
|
Does Knockout of Sh3gl2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Sh3gl2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Sh3gl2 (SH3-domain GRB2-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to brain-derived neurotrophic factor stimulus, dendrite extension, endocytosis, lipid tube assembly, membrane bending, membrane tubulation, negative regulation of MAPK cascade, negative regulation of blood-brain barrier permeability, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of gene expression, neuron projection development, positive regulation of membrane tubulation, postsynaptic actin cytoskeleton organization, regulation of clathrin-dependent endocytosis, regulation of receptor internalization, synaptic vesicle endocytosis, vesicle scission; MF: identical protein binding, lipid binding, protein binding, protein kinase binding, transmembrane transporter binding; CC: Schaffer collateral - CA1 synapse, cell projection, cytoplasm, early endosome, endosome, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane, perinuclear region of cytoplasm, photoreceptor ribbon synapse, postsynapse, presynapse, presynaptic cytosol, synapse, synaptic vesicle membrane
Pathways: Adaptive Immune System, Axon guidance, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, EGFR downregulation, Endocytosis - Mus musculus (mouse), Golgi Associated Vesicle Biogenesis, Immune System, L1CAM interactions, Lysosome Vesicle Biogenesis, MHC class II antigen presentation, Membrane Trafficking, Negative regulation of MET activity, Nervous system development, Recycling pathway of L1, Retrograde neurotrophin signalling, Signal Transduction, Signaling by EGFR, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q62420
Entrez ID: 20404
|
Does Knockout of Tmem130 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Tmem130
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tmem130 (transmembrane protein 130)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, Golgi membrane, membrane, plasma membrane
Pathways:
UniProt: Q6NXM3
Entrez ID: 243339
|
Does Knockout of Sarnp in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Sarnp
|
cell proliferation
|
Regulatory T cell
|
Gene: Sarnp (SAP domain containing ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, negative regulation of transcription by RNA polymerase II, poly(A)+ mRNA export from nucleus, regulation of translation; MF: DNA binding, RNA binding, chromatin binding; CC: cytoplasmic ribonucleoprotein granule, nuclear speck, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q9D1J3
Entrez ID: 66118
|
Does Knockout of Selenoi in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Selenoi
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Selenoi (selenoprotein I)
Type: protein-coding
Summary: The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: ether lipid biosynthetic process, lipid biosynthetic process, lipid metabolic process, myelination, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process; MF: ethanolaminephosphotransferase activity, metal ion binding, phosphotransferase activity, for other substituted phosphate groups, transferase activity; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Ether lipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Phosphonate and phosphinate metabolism - Mus musculus (mouse), Synthesis of PE, phosphatidylethanolamine biosynthesis II
UniProt: Q80TA1
Entrez ID: 28042
|
Does Knockout of Oas1c in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Oas1c
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Oas1c (2'-5' oligoadenylate synthetase 1C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to exogenous dsRNA, cellular response to interferon-alpha, cellular response to interferon-beta, defense response to bacterium, defense response to virus, glucose homeostasis, glucose metabolic process, interleukin-27-mediated signaling pathway, negative regulation of IP-10 production, negative regulation of chemokine (C-X-C motif) ligand 2 production, negative regulation of type I interferon-mediated signaling pathway, negative regulation of viral genome replication, positive regulation of cellular respiration, positive regulation of interferon-beta production, positive regulation of monocyte chemotactic protein-1 production, positive regulation of tumor necrosis factor production, protein complex oligomerization, response to virus, surfactant homeostasis, toll-like receptor 3 signaling pathway, toll-like receptor 4 signaling pathway, type I interferon-mediated signaling pathway; MF: 2'-5'-oligoadenylate synthetase activity, RNA binding, double-stranded RNA binding, nucleotidyltransferase activity; CC: cytoplasm, cytosol, membrane, mitochondrion, nucleoplasm, nucleus, ribosome
Pathways:
UniProt: Q924S2
Entrez ID: 114643
|
Does Knockout of Cysltr1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Cysltr1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cysltr1 (cysteinyl leukotriene receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium ion transport, cell surface receptor signaling pathway, cellular response to hypoxia, chemotaxis, endothelium development, establishment of localization in cell, inflammatory response to antigenic stimulus, leukotriene signaling pathway, neuropeptide signaling pathway, positive regulation of angiogenesis, positive regulation of glial cell proliferation, positive regulation of vasoconstriction, reactive oxygen species biosynthetic process, signal transduction; MF: G protein-coupled receptor activity, cysteinyl leukotriene receptor activity, galanin receptor activity, leukotriene receptor activity, protein binding; CC: membrane, plasma membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Leukotriene receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q99JA4
Entrez ID: 58861
|
Does Knockout of Cd300ld5 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Cd300ld5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cd300ld5 (CD300 molecule like family member D5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, immune system process; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: A2A7W1
Entrez ID: 100043125
|
Does Knockout of Msantd2 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Msantd2
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Msantd2 (Myb/SANT-like DNA-binding domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6NZR2
Entrez ID: 235184
|
Does Knockout of Sgf29 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Sgf29
|
cell cycle progression
|
breast epithelium
|
Gene: Sgf29 (SAGA complex associated factor 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of DNA repair, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of macromolecule metabolic process, regulation of nucleobase-containing compound metabolic process, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, transcription initiation-coupled chromatin remodeling; MF: histone H3K36me3 reader activity, histone H3K4me3 reader activity, methylation-dependent protein binding; CC: ATAC complex, SAGA complex, SAGA-type complex, mitotic spindle, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q9DA08
Entrez ID: 75565
|
Does Knockout of Ctdp1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Ctdp1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ctdp1 (CTD phosphatase subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, exit from mitosis, host-mediated activation of viral transcription, negative regulation of cell growth involved in cardiac muscle cell development, protein dephosphorylation, regulation of transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat phosphatase activity, TFIIF-class transcription factor complex binding, Tat protein binding, hydrolase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity; CC: centrosome, cytoplasm, cytoskeleton, midbody, nucleoplasm, nucleus, protein-containing complex, spindle, spindle midzone, spindle pole
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q7TSG2
Entrez ID: 67655
|
Does Knockout of Rab3il1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Rab3il1
|
phagocytosis
|
macrophage
|
Gene: Rab3il1 (RAB3A interacting protein (rabin3)-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, identical protein binding, kinase binding
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q8VDV3
Entrez ID: 74760
|
Does Knockout of Sdr9c7 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Sdr9c7
|
cell proliferation
|
Regulatory T cell
|
Gene: Sdr9c7 (4short chain dehydrogenase/reductase family 9C, member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: retinol metabolic process, steroid metabolic process; MF: all-trans-retinol dehydrogenase (NAD+) activity, oxidoreductase activity; CC: cytoplasm, intracellular membrane-bounded organelle
Pathways: Sensory Perception, The canonical retinoid cycle in rods (twilight vision), Visual phototransduction
UniProt: Q8K3P0
Entrez ID: 70061
|
Does Knockout of Prkra in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Prkra
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Prkra (protein kinase, interferon inducible double stranded RNA dependent activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RISC complex assembly, antiviral innate immune response, cellular response to oxidative stress, ear development, miRNA processing, middle ear morphogenesis, outer ear morphogenesis, positive regulation of cell population proliferation, positive regulation of intrinsic apoptotic signaling pathway, pre-miRNA processing, protein stabilization, regulation of regulatory ncRNA processing, regulatory ncRNA-mediated gene silencing, siRNA processing, skeletal system morphogenesis; MF: RNA binding, double-stranded RNA binding, enzyme binding, identical protein binding, pre-miRNA binding, protein binding, protein homodimerization activity, protein kinase activator activity, protein kinase binding, siRNA binding; CC: RISC complex, RISC-loading complex, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Gene Silencing by RNA, Gene expression (Transcription), Immune System, Interferon Signaling, MicroRNA (miRNA) biogenesis, PKR-mediated signaling, Small interfering RNA (siRNA) biogenesis
UniProt: Q9WTX2
Entrez ID: 23992
|
Does Knockout of Iqcc in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Iqcc
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Iqcc (IQ motif containing C)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2ADZ8
Entrez ID: 230767
|
Does Knockout of Lig4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Lig4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Lig4 (ligase IV, DNA, ATP-dependent)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DN2 thymocyte differentiation, DNA biosynthetic process, DNA damage response, DNA recombination, DNA repair, T cell receptor V(D)J recombination, V(D)J recombination, base-excision repair, cell division, cellular response to ionizing radiation, cellular response to lithium ion, central nervous system development, chromosome organization, double-strand break repair, double-strand break repair via classical nonhomologous end joining, double-strand break repair via nonhomologous end joining, fibroblast proliferation, immunoglobulin V(D)J recombination, in utero embryonic development, isotype switching, negative regulation of neuron apoptotic process, neuron apoptotic process, nucleotide-excision repair, DNA gap filling, positive regulation of chromosome organization, positive regulation of fibroblast proliferation, positive regulation of neurogenesis, pro-B cell differentiation, response to X-ray, response to gamma radiation, response to ionizing radiation, single strand break repair, somatic stem cell population maintenance, stem cell proliferation; MF: AMP binding, ATP binding, DNA binding, DNA ligase (ATP) activity, DNA ligase activity, ligase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding; CC: DNA ligase IV complex, DNA-dependent protein kinase-DNA ligase 4 complex, condensed chromosome, nonhomologous end joining complex, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ)
UniProt: Q8BTF7
Entrez ID: 319583
|
Does Knockout of Serpina9 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Serpina9
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Serpina9 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9D7D2
Entrez ID: 71907
|
Does Knockout of Pdzk1ip1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Pdzk1ip1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pdzk1ip1 (PDZK1 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: apical plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q9CQH0
Entrez ID: 67182
|
Does Knockout of Tubb6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Tubb6
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tubb6 (tubulin, beta 6 class V)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, GTPase activity, metal ion binding, nucleotide binding, structural constituent of cytoskeleton; CC: cytoplasm, cytoskeleton, intercellular bridge, microtubule, microtubule cytoskeleton, mitotic spindle
Pathways: Adaptive Immune System, Aggrephagy, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Asparagine N-linked glycosylation, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Cilium Assembly, Cytokine Signaling in Immune system, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, G2/M Transition, Gap junction - Mus musculus (mouse), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Mus musculus (mouse), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q922F4
Entrez ID: 67951
|
Does Knockout of Eif2ak2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Eif2ak2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to amino acid starvation, defense response to virus, endoplasmic reticulum unfolded protein response, immune system process, innate immune response, negative regulation of apoptotic process, negative regulation of osteoblast proliferation, negative regulation of translation, negative regulation of viral genome replication, positive regulation of MAPK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of apoptotic process, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of stress-activated MAPK cascade, protein autophosphorylation, regulation of NLRP3 inflammasome complex assembly, regulation of hematopoietic progenitor cell differentiation, regulation of hematopoietic stem cell differentiation, regulation of hematopoietic stem cell proliferation, regulation of translational initiation, response to interferon-alpha, response to lipopolysaccharide, response to toxic substance, response to virus, response to vitamin E, translation, translational initiation; MF: ATP binding, RNA binding, double-stranded RNA binding, eukaryotic translation initiation factor 2alpha kinase activity, identical protein binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleus, perinuclear region of cytoplasm
Pathways: Alzheimer disease - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), ISG15 antiviral mechanism, Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), PKR-mediated signaling, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q03963
Entrez ID: 19106
|
Does Knockout of Kiss1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Kiss1
|
phagocytosis
|
macrophage
|
Gene: Kiss1 (KiSS-1 metastasis-suppressor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, decidualization, generation of ovulation cycle rhythm, negative regulation of cell population proliferation, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of cytosolic calcium ion concentration, positive regulation of growth hormone secretion, positive regulation of luteinizing hormone secretion, positive regulation of synaptic transmission; MF: kisspeptin receptor binding, protein binding; CC: apical plasma membrane, extracellular region, extracellular space, neuronal cell body
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GnRH secretion - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q6Y4S4
Entrez ID: 280287
|
Does Knockout of Fgr in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Fgr
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fgr (FGR proto-oncogene, Src family tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, cell differentiation, cell surface receptor protein tyrosine kinase signaling pathway, defense response to Gram-positive bacterium, immune system process, innate immune response, integrin-mediated signaling pathway, negative regulation of natural killer cell activation, peptidyl-tyrosine phosphorylation, positive regulation of cell migration, positive regulation of cytokine production, positive regulation of mast cell degranulation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of actin cytoskeleton organization, regulation of cell shape, regulation of innate immune response, regulation of phagocytosis, regulation of protein kinase activity, skeletal system morphogenesis; MF: ATP binding, Fc-gamma receptor I complex binding, immunoglobulin receptor binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphotyrosine residue binding, protein binding, protein kinase activity, protein kinase binding, protein tyrosine kinase activity, signaling receptor binding, transferase activity; CC: actin cytoskeleton, aggresome, cell projection, cytoplasm, cytoskeleton, cytosol, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, plasma membrane, ruffle membrane
Pathways: Chemokine signaling pathway - Mus musculus (mouse), FCGR activation, Fcgamma receptor (FCGR) dependent phagocytosis, Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation, Platelet homeostasis, Platelet sensitization by LDL
UniProt: P14234
Entrez ID: 14191
|
Does Knockout of Tdrd1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Tdrd1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tdrd1 (tudor domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P granule organization, cell differentiation, germ cell development, meiotic cell cycle, piRNA processing, regulatory ncRNA-mediated gene silencing, spermatogenesis, transposable element silencing by piRNA-mediated DNA methylation; MF: metal ion binding, protein binding, zinc ion binding; CC: P granule, chromatoid body, cytoplasm, cytosol, pi-body, ribonucleoprotein complex, synapse
Pathways:
UniProt: Q99MV1
Entrez ID: 83561
|
Does Knockout of Trp73 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Trp73
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Trp73 (transformation related protein 73)
Type: protein-coding
Summary: This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, apoptotic process, cerebrospinal fluid secretion, digestive tract morphogenesis, forebrain development, hippocampus development, inflammatory response, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, kidney development, negative regulation of cardiac muscle cell proliferation, negative regulation of cell population proliferation, negative regulation of neuron apoptotic process, negative regulation of neuron differentiation, neuron development, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, positive regulation of cell size, positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of lung ciliated cell differentiation, positive regulation of oligodendrocyte differentiation, positive regulation of transcription by RNA polymerase II, post-embryonic development, protein tetramerization, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of gene expression, regulation of mitotic cell cycle, regulation of neuron apoptotic process, release of cytochrome c from mitochondria, response to xenobiotic stimulus; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, MDM2/MDM4 family protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, identical protein binding, metal ion binding, p53 binding, promoter-specific chromatin binding, protein binding, protein kinase binding, sequence-specific DNA binding, transcription cis-regulatory region binding, transcription corepressor binding; CC: Golgi apparatus, cell junction, centrosome, chromatin, ciliary basal body, cytoplasm, nucleoplasm, nucleus, plasma membrane
Pathways: Hippo signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: Q9JJP2
Entrez ID: 22062
|
Does Knockout of Epm2a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Epm2a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Epm2a (epilepsy, progressive myoclonic epilepsy, type 2 gene alpha)
Type: protein-coding
Summary: Enables several functions, including alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity; phosphatase activity; and starch binding activity. Involved in carbohydrate phosphorylation and glycogen biosynthetic process. Acts upstream of or within several processes, including habituation; regulation of protein localization; and regulation of protein metabolic process. Located in several cellular components, including cytoplasmic side of endoplasmic reticulum membrane; dendrite; and perikaryon. Is active in cytosol. Is expressed in several structures, including brain. Used to study Lafora disease and lymphoma. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to human EPM2A (EPM2A glucan phosphatase, laforin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: L-glutamate transmembrane transport, Wnt signaling pathway, autophagosome assembly, autophagy, calcium ion transport, carbohydrate phosphorylation, glial cell proliferation, glycogen biosynthetic process, glycogen metabolic process, habituation, mitochondrion organization, negative regulation of TOR signaling, negative regulation of cell cycle, negative regulation of dephosphorylation, negative regulation of gene expression, negative regulation of metabolic process, nervous system development, phosphate-containing compound metabolic process, positive regulation of macroautophagy, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of cell growth, regulation of gene expression, regulation of proteasomal protein catabolic process, regulation of protein import into nucleus, regulation of protein localization to plasma membrane, regulation of protein ubiquitination; MF: carbohydrate binding, carbohydrate phosphatase activity, glycogen binding, hydrolase activity, identical protein binding, phosphatase activity, phosphoprotein phosphatase activity, polysaccharide binding, protein binding, protein dimerization activity, protein homodimerization activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, starch binding; CC: cytoplasm, cytoplasmic side of endoplasmic reticulum membrane, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm, nucleus, perikaryon, plasma membrane
Pathways:
UniProt: Q9WUA5
Entrez ID: 13853
|
Does Knockout of Dynlt3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Dynlt3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Dynlt3 (dynein light chain Tctex-type 3)
Type: protein-coding
Summary: Predicted to enable dynein intermediate chain binding activity and identical protein binding activity. Predicted to be involved in microtubule-based movement and positive regulation of mitotic cell cycle. Predicted to be located in mitotic spindle astral microtubule. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Predicted to colocalize with kinetochore. Is expressed in several structures, including central nervous system; gut; lower urinary tract; nose; and submandibular gland primordium. Orthologous to human DYNLT3 (dynein light chain Tctex-type 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, microtubule-based movement, positive regulation of mitotic cell cycle, regulation of mitotic cell cycle; MF: dynein intermediate chain binding, identical protein binding, protein binding; CC: chromosome, chromosome, centromeric region, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, kinetochore, microtubule, mitotic spindle astral microtubule, nucleus
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: P56387
Entrez ID: 67117
|
Does Knockout of Ell3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Ell3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ell3 (elongation factor RNA polymerase II-like 3)
Type: protein-coding
Summary: Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of epithelial to mesenchymal transition; and transcription by RNA polymerase II. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of cell population proliferation; and positive regulation of neurogenesis. Located in nucleus. Is expressed in embryo endoderm and olfactory epithelium. Orthologous to human ELL3 (elongation factor for RNA polymerase II 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA-templated transcription elongation, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of signal transduction by p53 class mediator, positive regulation of DNA-templated transcription, elongation, positive regulation of neural precursor cell proliferation, positive regulation of neurogenesis, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of epithelial to mesenchymal transition, snRNA transcription by RNA polymerase II, stem cell differentiation, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: cis-regulatory region sequence-specific DNA binding, protein binding; CC: cell junction, chromosome, cytosol, nuclear speck, nucleolus, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q80VR2
Entrez ID: 269344
|
Does Knockout of Atp13a2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Atp13a2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Atp13a2 (ATPase type 13A2)
Type: protein-coding
Summary: Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; phospholipid binding activity; and polyamine transmembrane transporter activity. Involved in several processes, including autophagosome-lysosome fusion; intracellular zinc ion homeostasis; and positive regulation of exosomal secretion. Located in neuron projection; neuronal cell body; and vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study Kufor-Rakeb syndrome. Human ortholog(s) of this gene implicated in Kufor-Rakeb syndrome; Parkinson's disease; and hereditary spastic paraplegia 78. Orthologous to human ATP13A2 (ATPase cation transporting 13A2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: autophagosome organization, autophagosome-lysosome fusion, autophagy, cellular response to manganese ion, cellular response to oxidative stress, extracellular exosome biogenesis, intracellular calcium ion homeostasis, intracellular iron ion homeostasis, intracellular zinc ion homeostasis, lipid homeostasis, lysosomal transport, monoatomic cation transmembrane transport, polyamine transmembrane transport, positive regulation of exosomal secretion, positive regulation of gene expression, positive regulation of protein secretion, protein localization to lysosome, regulation of autophagosome size, regulation of intracellular protein transport, regulation of lysosomal protein catabolic process, regulation of macroautophagy, regulation of mitochondrion organization, regulation of protein localization to nucleus, spermine transmembrane transport; MF: ABC-type polyamine transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled monoatomic cation transmembrane transporter activity, P-type ion transporter activity, P-type transmembrane transporter activity, metal ion binding, nucleotide binding, phosphatidic acid binding, phosphatidylinositol-3,5-bisphosphate binding, polyamine transmembrane transporter activity; CC: autophagosome, autophagosome membrane, cytoplasmic vesicle, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, multivesicular body, multivesicular body membrane, neuron projection, neuronal cell body, transport vesicle, vesicle, vesicle membrane
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: Q9CTG6
Entrez ID: 74772
|
Does Knockout of Ifng in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Ifng
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ifng (interferon gamma)
Type: protein-coding
Summary: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: CD8-positive, alpha-beta T cell differentiation involved in immune response, Fc-gamma receptor signaling pathway involved in phagocytosis, T cell receptor signaling pathway, adaptive immune response, antigen processing and presentation, apoptotic process, astrocyte activation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, cellular response to interleukin-18, cellular response to lipopolysaccharide, creatinine metabolic process, defense response to Gram-positive bacterium, defense response to bacterium, defense response to protozoan, defense response to virus, endoplasmic reticulum unfolded protein response, extrinsic apoptotic signaling pathway, host-mediated activation of viral process, humoral immune response, immune response, inflammatory cell apoptotic process, interleukin-2-mediated signaling pathway, macrophage activation involved in immune response, macrophage differentiation, microglial cell activation, negative regulation of DNA-templated transcription, negative regulation of amyloid-beta clearance, negative regulation of cell population proliferation, negative regulation of epithelial cell differentiation, negative regulation of fibroblast proliferation, negative regulation of gene expression, negative regulation of glomerular mesangial cell proliferation, negative regulation of interleukin-17 production, negative regulation of myelination, negative regulation of osteoclast differentiation, negative regulation of smooth muscle cell proliferation, negative regulation of transcription by RNA polymerase II, neuroinflammatory response, neutrophil apoptotic process, neutrophil chemotaxis, positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response, positive regulation of DNA-templated transcription, positive regulation of MHC class II biosynthetic process, positive regulation of T cell cytokine production, positive regulation of T cell proliferation, positive regulation of amyloid-beta formation, positive regulation of apoptotic process, positive regulation of autophagy, positive regulation of cell adhesion, positive regulation of cell population proliferation, positive regulation of cellular respiration, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of epithelial cell migration, positive regulation of fructose 1,6-bisphosphate metabolic process, positive regulation of gene expression, positive regulation of glutamate receptor signaling pathway, positive regulation of glycolytic process, positive regulation of inflammatory response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-12 production, positive regulation of interleukin-23 production, positive regulation of interleukin-6 production, positive regulation of iron ion import across plasma membrane, positive regulation of isotype switching to IgG isotypes, positive regulation of macrophage cytokine production, positive regulation of membrane protein ectodomain proteolysis, positive regulation of monoatomic ion transmembrane transport, positive regulation of neurogenesis, positive regulation of neuron differentiation, positive regulation of nitric oxide biosynthetic process, positive regulation of osteoclast differentiation, positive regulation of phagocytosis, positive regulation of protein deacetylation, positive regulation of protein import into nucleus, positive regulation of protein-containing complex assembly, positive regulation of receptor signaling pathway via STAT, positive regulation of smooth muscle cell apoptotic process, positive regulation of synaptic transmission, cholinergic, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor (ligand) superfamily member 11 production, positive regulation of tumor necrosis factor production, positive regulation of vitamin D biosynthetic process, regulation of DNA-templated transcription, regulation of defense response to virus by host, regulation of glial cell proliferation, regulation of hepatocyte proliferation, regulation of immune response, regulation of insulin secretion, regulation of nervous system process, regulation of neuronal action potential, regulation of the force of heart contraction, response to sodium arsenite, response to virus, sensory perception of mechanical stimulus, type II interferon-mediated signaling pathway, type III interferon-mediated signaling pathway, urea metabolic process; MF: cytokine activity, protein binding, type II interferon receptor binding; CC: external side of plasma membrane, extracellular region, extracellular space, perikaryon
Pathways: African trypanosomiasis - Mus musculus (mouse), Allograft rejection - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), IFNG signaling activates MAPKs, IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Malaria - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Regulation of IFNG signaling, Rheumatoid arthritis - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse)
UniProt: P01580
Entrez ID: 15978
|
Does Knockout of Mtmr4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Mtmr4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mtmr4 (myotubularin related protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: midbody abscission, negative regulation of BMP signaling pathway, negative regulation of endocytic recycling, negative regulation of transforming growth factor beta receptor signaling pathway, phagosome maturation, phosphatidylinositol biosynthetic process, phosphatidylinositol dephosphorylation, response to denervation involved in regulation of muscle adaptation; MF: R-SMAD binding, hydrolase activity, metal ion binding, molecular adaptor activity, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity, protein phosphatase binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, cytosol, early endosome membrane, early phagosome membrane, endosome, endosome membrane, late endosome membrane, membrane, phagocytic vesicle membrane, recycling endosome membrane
Pathways: Autophagy - animal - Mus musculus (mouse), Downregulation of TGF-beta receptor signaling, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, TGF-beta receptor signaling activates SMADs
UniProt: Q91XS1
Entrez ID: 170749
|
Does Knockout of Pafah1b2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,185
|
Knockout
|
Pafah1b2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pafah1b2 (platelet-activating factor acetylhydrolase, isoform 1b, subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid catabolic process, lipid metabolic process, positive regulation of macroautophagy, spermatogenesis; MF: 1-alkyl-2-acetylglycerophosphocholine esterase activity, hydrolase activity, identical protein binding, platelet-activating factor acetyltransferase activity, protein binding, protein heterodimerization activity, protein homodimerization activity, protein-containing complex binding; CC: 1-alkyl-2-acetylglycerophosphocholine esterase complex, cytoplasm, cytosol, fibrillar center, nucleolus, plasma membrane
Pathways: COPI-independent Golgi-to-ER retrograde traffic, Ether lipid metabolism - Mus musculus (mouse), Golgi-to-ER retrograde transport, Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Neutrophil degranulation, Vesicle-mediated transport
UniProt: Q61206
Entrez ID: 18475
|
Does Knockout of Rnf7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Rnf7
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Rnf7 (ring finger protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, apoptotic mitochondrial changes, cGAS/STING signaling pathway, cerebral cortex radially oriented cell migration, defense response to virus, endoplasmic reticulum unfolded protein response, epithelial to mesenchymal transition, erythropoietin-mediated signaling pathway, growth hormone receptor signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, innate immune response, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to oxidative stress, negative regulation of apoptotic process, negative regulation of focal adhesion assembly, negative regulation of growth hormone receptor signaling pathway, phosphocreatine biosynthetic process, positive regulation of focal adhesion assembly, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein neddylation, protein ubiquitination, radial glia guided migration of Purkinje cell, reelin-mediated signaling pathway, regulation of neuron migration, ubiquitin-dependent protein catabolic process; MF: NEDD8 ligase activity, cullin family protein binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: Cul5-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of CSF3 (G-CSF) signaling, Metabolism of proteins, Neddylation, Post-translational protein modification, Signaling by CSF3 (G-CSF), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9WTZ1
Entrez ID: 19823
|
Does Knockout of Enho in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Enho
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Enho (energy homeostasis associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, energy homeostasis, positive regulation of Notch signaling pathway; MF: hormone activity, protein binding; CC: extracellular region, extracellular space, plasma membrane
Pathways:
UniProt: Q8K1D8
Entrez ID: 69638
|
Does Knockout of Cspp1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Cspp1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Cspp1 (centrosome and spindle pole associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell division, positive regulation of cytokinesis; CC: cell projection, centriolar satellite, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule, nucleoplasm, spindle, spindle pole
Pathways:
UniProt: B2RX88
Entrez ID: 211660
|
Does Knockout of Bcl6 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,541
|
Knockout
|
Bcl6
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Bcl6 (B cell leukemia/lymphoma 6)
Type: protein-coding
Summary: Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of lymphocyte activation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell differentiation, DNA damage response, Rho protein signal transduction, actin cytoskeleton organization, cell morphogenesis, erythrocyte development, germinal center formation, heterochromatin formation, immune system process, inflammatory response, intracellular protein localization, memory T cell proliferation, negative regulation of DNA-templated transcription, negative regulation of Notch signaling pathway, negative regulation of Rho protein signal transduction, negative regulation of T-helper 2 cell differentiation, negative regulation of apoptotic process, negative regulation of cell growth, negative regulation of cell-matrix adhesion, negative regulation of cellular senescence, negative regulation of isotype switching to IgE isotypes, negative regulation of mast cell cytokine production, negative regulation of mononuclear cell proliferation, negative regulation of plasma cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of type 2 immune response, positive regulation of B cell proliferation, positive regulation of apoptotic process, positive regulation of cell differentiation, positive regulation of cell motility, positive regulation of lymphocyte activation, positive regulation of neuron differentiation, positive regulation of regulatory T cell differentiation, pyramidal neuron differentiation, regulation of T cell differentiation, regulation of T cell proliferation, regulation of apoptotic process, regulation of cell differentiation, regulation of cell population proliferation, regulation of cytokine production, regulation of immune system process, regulation of inflammatory response, regulation of leukocyte cell-cell adhesion, regulation of memory T cell differentiation, regulation of transcription by RNA polymerase II, spermatogenesis, type 2 immune response; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, identical protein binding, intronic transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription corepressor binding, zinc ion binding; CC: Golgi apparatus, nucleolus, nucleoplasm, nucleus, paraspeckles, replication fork
Pathways: Chemical carcinogenesis - receptor activation - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P41183
Entrez ID: 12053
|
Does Knockout of Ndufs8 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Ndufs8
|
response to virus
|
Microglial Cell Line
|
Gene: Ndufs8 (NADH:ubiquinone oxidoreductase core subunit S8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 4 iron, 4 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q8K3J1
Entrez ID: 225887
|
Does Knockout of Sla in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Sla
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sla (src-like adaptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of MAPK cascade, signal transduction; MF: epidermal growth factor receptor binding, phosphotyrosine residue binding, protein binding; CC: COP9 signalosome, cytoplasm, endosome, nucleoplasm, plasma membrane
Pathways: Cytokine Signaling in Immune system, FLT3 Signaling, Immune System, Negative regulation of FLT3
UniProt: Q60898
Entrez ID: 20491
|
Does Knockout of Usp9y in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Usp9y
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Usp9y (ubiquitin specific peptidase 9, Y chromosome)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, protein deubiquitination, protein ubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity; CC: cytosol, nucleus
Pathways:
UniProt: F8VPU6
Entrez ID: 107868
|
Does Knockout of Vmn2r98 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Vmn2r98
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn2r98 (vomeronasal 2, receptor 98)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: E9PZ56
Entrez ID: 224552
|
Does Knockout of Acvr1c in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Acvr1c
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Acvr1c (activin A receptor, type IC)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SMAD protein signal transduction, activin receptor signaling pathway, apoptotic nuclear changes, apoptotic process, apoptotic signaling pathway, cell communication, cell differentiation, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to growth factor stimulus, lipid storage, negative regulation of chorionic trophoblast cell proliferation, negative regulation of insulin secretion, negative regulation of trophoblast cell migration, nervous system development, nodal signaling pathway, positive regulation of apoptotic process, regulation of apoptotic process, response to dietary excess, response to glucose, response to insulin, signaling, transforming growth factor beta receptor complex assembly, trophectodermal cell proliferation; MF: ATP binding, BMP receptor binding, SMAD binding, activin binding, activin receptor activity, activin receptor activity, type I, growth factor binding, kinase activity, metal ion binding, nodal binding, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transmembrane receptor protein serine/threonine kinase activity; CC: activin receptor complex, cell surface, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by Activin, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: Q8K348
Entrez ID: 269275
|
Does Knockout of Hapln3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Hapln3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Hapln3 (hyaluronan and proteoglycan link protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, central nervous system development, skeletal system development; CC: extracellular matrix, extracellular region, extracellular space, perineuronal net, synapse
Pathways:
UniProt: Q80WM5
Entrez ID: 67666
|
Does Knockout of Sfxn2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Sfxn2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sfxn2 (sideroflexin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, mitochondrial transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, serine import into mitochondrion, transmembrane transport; MF: monoatomic ion transmembrane transporter activity, transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q925N2
Entrez ID: 94279
|
Does Knockout of A830005F24Rik in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
A830005F24Rik
|
phagocytosis
|
macrophage
|
Gene: A830005F24Rik (RIKEN cDNA A830005F24 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Nucks1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Nucks1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nucks1 (nuclear casein kinase and cyclin-dependent kinase substrate 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to X-ray, chromatin organization, double-strand break repair via homologous recombination, glucose homeostasis, host-mediated activation of viral genome replication, host-mediated activation of viral transcription, host-mediated perturbation of viral genome replication, interstrand cross-link repair, intracellular glucose homeostasis, positive regulation of insulin receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA replication, regulation of DNA strand elongation, regulation of insulin receptor signaling pathway, regulation of transcription by RNA polymerase II, replication fork processing; MF: DNA-binding transcription factor binding, chromatin binding, double-stranded DNA binding, single-stranded DNA binding, transcription coactivator activity; CC: chromatin, chromosome, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q80XU3
Entrez ID: 98415
|
Does Knockout of F2rl2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
F2rl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: F2rl2 (coagulation factor II thrombin receptor like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, blood coagulation, hemostasis, ligand-gated ion channel signaling pathway, positive regulation of insulin secretion, regulation of biological quality, regulation of protein secretion, signal transduction, thrombin-activated receptor signaling pathway; MF: G protein-coupled receptor activity, proteinase-activated receptor activity, receptor ligand activity, thrombin-activated receptor activity; CC: apical plasma membrane, membrane, plasma membrane, protein-containing complex
Pathways: Class A/1 (Rhodopsin-like receptors), Complement and coagulation cascades - Mus musculus (mouse), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Hemostasis, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Platelet activation, signaling and aggregation, Signal Transduction, Signaling by GPCR, Thrombin signalling through proteinase activated receptors (PARs)
UniProt: O08675
Entrez ID: 14064
|
Does Knockout of Fxyd3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Fxyd3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Fxyd3 (FXYD domain-containing ion transport regulator 3)
Type: protein-coding
Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The encoded protein is a transmembrane protein that functions as a specific regulator of Na,K-ATPase. [provided by RefSeq, Aug 2009].
Gene Ontology: BP: monoatomic ion transport, positive regulation of sodium ion export across plasma membrane, potassium ion transport, regulation of monoatomic ion transport, sodium ion transport; MF: ATPase binding, ion channel regulator activity, protein binding, sodium channel regulator activity; CC: endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Cardiac conduction, Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Muscle contraction, Transport of small molecules
UniProt: Q61835
Entrez ID: 17178
|
Does Knockout of Gm1123 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Gm1123
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gm1123 (predicted gene 1123)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: adherens junction, anchoring junction, basolateral plasma membrane, bicellular tight junction, intercalated disc
Pathways:
UniProt: Q1RME4
Entrez ID: 382097
|
Does Knockout of Adrm1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Adrm1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Adrm1 (adhesion regulating molecule 1 26S proteasome ubiquitin receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Sertoli cell development, adipose tissue development, follicle-stimulating hormone signaling pathway, oogenesis, ovarian follicle development, positive regulation of growth hormone receptor signaling pathway, proteasome assembly, regulation of T cell differentiation in thymus, seminiferous tubule development, spermatid development, thymus development, transcription elongation by RNA polymerase II; MF: endopeptidase activator activity, molecular function inhibitor activity, protease binding, proteasome binding, protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane, proteasome complex, proteasome regulatory particle, lid subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9JKV1
Entrez ID: 56436
|
Does Knockout of Arhgap17 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Arhgap17
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arhgap17 (Rho GTPase activating protein 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, calcium-ion regulated exocytosis, negative regulation of small GTPase mediated signal transduction, regulation of Rac protein signal transduction, regulation of actin cytoskeleton organization, signal transduction; MF: GTPase activator activity, SH3 domain binding, protein binding; CC: anchoring junction, bicellular tight junction, cytoplasm, cytosol, membrane, plasma membrane
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOD GTPase cycle, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse)
UniProt: Q3UIA2
Entrez ID: 70497
|
Does Knockout of Vmn1r49 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Vmn1r49
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn1r49 (vomeronasal 1, receptor 49)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q9WUF1
Entrez ID: 24112
|
Does Knockout of Zfas1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Zfas1
|
phagocytosis
|
macrophage
|
Gene: Zfas1 (zinc finger, NFX1-type containing 1, antisense RNA 1)
Type: ncRNA
Summary: No summary available.
Gene Ontology: BP: cardiac muscle contraction, mammary gland epithelial cell differentiation, negative regulation of calcium ion transmembrane transport, negative regulation of mammary gland epithelial cell proliferation, positive regulation of cardiac muscle cell apoptotic process, regulation of hypoxia-induced intrinsic apoptotic signaling pathway; MF: molecular function inhibitor activity, transmembrane transporter binding; CC: cytoplasm, nucleus, sarcoplasm, sarcoplasmic reticulum
Pathways:
UniProt:
Entrez ID: 68949
|
Does Knockout of Zfp354c in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Zfp354c
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp354c (zinc finger protein 354C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, negative regulation of sprouting angiogenesis, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: cytoplasm, membrane, nuclear membrane, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q571J5
Entrez ID: 30944
|
Does Knockout of Akr1c12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Akr1c12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Akr1c12 (aldo-keto reductase family 1, member C12)
Type: protein-coding
Summary: Predicted to enable several functions, including ketosteroid monooxygenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Predicted to be involved in several processes, including cellular response to jasmonic acid stimulus; glycoside metabolic process; and prostaglandin metabolic process. Predicted to act upstream of or within xenobiotic metabolic process. Predicted to be active in cytosol. Is expressed in gut; male reproductive system; and mesonephros. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: daunorubicin metabolic process, doxorubicin metabolic process, progesterone metabolic process, prostaglandin metabolic process, xenobiotic metabolic process; MF: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity, Delta4-3-oxosteroid 5beta-reductase activity, alcohol dehydrogenase (NADP+) activity, aldose reductase (NADPH) activity, all-trans-retinol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, bile acid binding, carboxylic acid binding, chlordecone reductase activity, geranylgeranyl reductase activity, ketoreductase activity, ketosteroid monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, prostaglandin D2 11-ketoreductase activity, prostaglandin H2 endoperoxidase reductase activity, retinal dehydrogenase (NAD+) activity, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q9JLI0
Entrez ID: 622402
|
Does Knockout of Prdm2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Prdm2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Prdm2 (PR domain containing 2, with ZNF domain)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within determination of adult lifespan. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in nucleus. Is expressed in forelimb cartilage condensation; forelimb long bone; and tendon. Orthologous to human PRDM2 (PR/SET domain 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromatin remodeling, determination of adult lifespan, methylation, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, response to estradiol; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, histone methyltransferase activity, metal ion binding, methyltransferase activity, sequence-specific DNA binding, transferase activity, zinc ion binding; CC: Golgi apparatus, nucleoplasm, nucleus
Pathways: Lysine degradation - Mus musculus (mouse)
UniProt: A2A7B5, Q8C2W5, B9EKQ3, A2A7B7
Entrez ID: 110593
|
Does Knockout of Pdcl in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,269
|
Knockout
|
Pdcl
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pdcl (phosducin-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, heterotrimeric G-protein complex assembly, negative regulation of protein refolding, positive regulation of smoothened signaling pathway, protein folding, regulation of G protein-coupled receptor signaling pathway, visual perception; CC: cell projection, cilium, cytoplasm
Pathways: Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: Q9DBX2
Entrez ID: 67466
|
Does Knockout of Acer2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Acer2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Acer2 (alkaline ceramidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, cellular response to xenobiotic stimulus, ceramide catabolic process, ceramide metabolic process, lipid metabolic process, negative regulation of cell adhesion mediated by integrin, negative regulation of cell-matrix adhesion, positive regulation of cell population proliferation, regulation of apoptotic process, regulation of autophagy, regulation of protein glycosylation, response to retinoic acid, sphingolipid metabolic process, sphingosine biosynthetic process; MF: N-acylsphingosine amidohydrolase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, metal ion binding; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism, Metabolism of lipids, Sphingolipid catabolism, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), sphingosine and sphingosine-1-phosphate metabolism
UniProt: Q8VD53
Entrez ID: 230379
|
Does Knockout of Ackr1 in Microglial Cell Line causally result in cell proliferation?
| 0
| 1,359
|
Knockout
|
Ackr1
|
cell proliferation
|
Microglial Cell Line
|
Gene: Ackr1 (atypical chemokine receptor 1 (Duffy blood group))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, chemokine-mediated signaling pathway, inflammatory response, regulation of chemokine production, signal transduction; MF: C-C chemokine binding, G protein-coupled receptor activity, chemokine binding; CC: early endosome, endosome, membrane, recycling endosome
Pathways: Malaria - Mus musculus (mouse)
UniProt: Q9QUI6
Entrez ID: 13349
|
Does Knockout of Htr5b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Htr5b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Htr5b (5-hydroxytryptamine (serotonin) receptor 5B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-inhibiting serotonin receptor signaling pathway, chemical synaptic transmission, signal transduction; MF: G protein-coupled receptor activity, G protein-coupled receptor binding, G protein-coupled serotonin receptor activity, Gi/o-coupled serotonin receptor activity, neurotransmitter receptor activity; CC: dendrite, membrane, plasma membrane, synapse
Pathways: Calcium signaling pathway - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse)
UniProt: G3X9C6
Entrez ID: 15564
|
Does Knockout of Tacr2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Tacr2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tacr2 (tachykinin receptor 2)
Type: protein-coding
Summary: Predicted to enable substance K receptor activity. Involved in regulation of uterine smooth muscle contraction. Predicted to be located in sperm flagellum and sperm head. Predicted to be active in plasma membrane and sperm midpiece. Is expressed in adrenal gland and renal vasculature. Human ortholog(s) of this gene implicated in asthma. Orthologous to human TACR2 (tachykinin receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, intestine smooth muscle contraction, negative regulation of luteinizing hormone secretion, operant conditioning, positive regulation of acetylcholine secretion, neurotransmission, positive regulation of flagellated sperm motility, positive regulation of monoatomic ion transport, positive regulation of uterine smooth muscle contraction, positive regulation of vascular permeability, prolactin secretion, regulation of uterine smooth muscle contraction, response to electrical stimulus, signal transduction, tachykinin receptor signaling pathway; MF: G protein-coupled receptor activity, substance K receptor activity, tachykinin receptor activity; CC: membrane, plasma membrane, sperm flagellum, sperm head, sperm midpiece
Pathways: Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Tachykinin receptors bind tachykinins
UniProt: P30549
Entrez ID: 21337
|
Does Knockout of Zfp82 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Zfp82
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Zfp82 (zinc finger protein 82)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q6P9Y7
Entrez ID: 330502
|
Does Knockout of Ceacam1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Ceacam1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ceacam1 (CEA cell adhesion molecule 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid and bile salt transport, blood vessel development, cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, cell-cell junction organization, cellular response to insulin stimulus, common myeloid progenitor cell proliferation, granulocyte colony-stimulating factor signaling pathway, homophilic cell adhesion via plasma membrane adhesion molecules, insulin catabolic process, insulin receptor internalization, negative regulation of JNK cascade, negative regulation of T cell mediated cytotoxicity, negative regulation of T cell proliferation, negative regulation of T cell receptor signaling pathway, negative regulation of bone resorption, negative regulation of cell population proliferation, negative regulation of cytokine production, negative regulation of cytotoxic T cell degranulation, negative regulation of fatty acid biosynthetic process, negative regulation of granulocyte differentiation, negative regulation of hepatocyte proliferation, negative regulation of interleukin-1 production, negative regulation of interleukin-2 production, negative regulation of lipid biosynthetic process, negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, negative regulation of osteoclast differentiation, negative regulation of platelet aggregation, negative regulation of protein kinase activity, negative regulation of vascular permeability, positive regulation of JNK cascade, positive regulation of homophilic cell adhesion, positive regulation of vasculogenesis, regulation of ERK1 and ERK2 cascade, regulation of blood vessel remodeling, regulation of cell growth, regulation of cell migration, regulation of endothelial cell differentiation, regulation of endothelial cell migration, regulation of epidermal growth factor receptor signaling pathway, regulation of homophilic cell adhesion, regulation of immune system process, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of sprouting angiogenesis, signal transduction, symbiont entry into host cell, wound healing, spreading of cells; MF: Toll-like receptor binding, actin binding, bile acid transmembrane transporter activity, calmodulin binding, filamin binding, granulocyte colony-stimulating factor receptor binding, identical protein binding, kinase binding, protein binding, protein dimerization activity, protein homodimerization activity, protein kinase binding, protein phosphatase binding, protein tyrosine kinase binding, virus receptor activity; CC: T cell receptor complex, adherens junction, anchoring junction, apical plasma membrane, basal plasma membrane, cell junction, cell projection, cell surface, cell-cell junction, ciliary membrane, cytoplasmic vesicle, external side of plasma membrane, lateral plasma membrane, membrane, microvillus membrane, plasma membrane, transport vesicle
Pathways: Cell surface interactions at the vascular wall, Extracellular matrix organization, Fibronectin matrix formation, Hemostasis, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: P31809
Entrez ID: 26365
|
Does Knockout of Vav1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Vav1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vav1 (vav 1 oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell proliferation, G protein-coupled receptor signaling pathway, T cell activation, T cell costimulation, T cell differentiation, cell migration, cell surface receptor signaling pathway, immune response, immune response-regulating cell surface receptor signaling pathway, integrin-mediated signaling pathway, intracellular signal transduction, natural killer cell activation, natural killer cell mediated cytotoxicity, neutrophil chemotaxis, phagocytosis, positive regulation of cell adhesion, positive regulation of natural killer cell mediated cytotoxicity, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, reactive oxygen species metabolic process, regulation of immune response, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, metal ion binding, phosphorylation-dependent protein binding, phosphotyrosine residue binding, protein binding, zinc ion binding; CC: cell-cell junction, cytoplasm, cytosol
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Azathioprine ADME, B cell receptor signaling pathway - Mus musculus (mouse), CD28 dependent Vav1 pathway, Cell death signalling via NRAGE, NRIF and NADE, Chemokine signaling pathway - Mus musculus (mouse), Co-stimulation by CD28, Cytokine Signaling in Immune system, Death Receptor Signaling, Drug ADME, Erythropoietin activates RAS, FCERI mediated Ca+2 mobilization, FCERI mediated MAPK activation, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Focal adhesion - Mus musculus (mouse), G alpha (12/13) signalling events, GPCR downstream signalling, GPVI-mediated activation cascade, Hemostasis, Immune System, Innate Immune System, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), NRAGE signals death through JNK, Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Platelet activation, signaling and aggregation, Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOG GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Regulation of signaling by CBL, Signal Transduction, Signaling by Erythropoietin, Signaling by GPCR, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by VEGF, Signaling by the B Cell Receptor (BCR), T cell receptor signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: P27870
Entrez ID: 22324
|
Does Knockout of Tchh in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Tchh
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tchh (trichohyalin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermediate filament organization; MF: calcium ion binding, metal ion binding, protein-macromolecule adaptor activity, transition metal ion binding
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: A0A0B4J1F9
Entrez ID: 99681
|
Does Knockout of 4930596D02Rik in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
4930596D02Rik
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: 4930596D02Rik (RIKEN cDNA 4930596D02 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways:
UniProt: Q3V0H9
Entrez ID: 239036
|
Does Knockout of Hip1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Hip1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hip1 (huntingtin interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, apoptotic process, apoptotic signaling pathway, cell differentiation, clathrin coat assembly, endocytosis, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of platelet-derived growth factor receptor-beta signaling pathway, positive regulation of receptor-mediated endocytosis, presynaptic modulation of chemical synaptic transmission, protein stabilization, regulation of apoptotic process, regulation of biological quality, regulation of cell communication, regulation of postsynaptic neurotransmitter receptor internalization, regulation of signaling; MF: AP-2 adaptor complex binding, actin binding, actin filament binding, clathrin adaptor activity, clathrin binding, clathrin light chain binding, phosphatidylinositol binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phospholipid binding, protein binding, protein heterodimerization activity, protein homodimerization activity; CC: Golgi apparatus, Schaffer collateral - CA1 synapse, clathrin-coated vesicle, clathrin-coated vesicle membrane, cortical actin cytoskeleton, cytoplasm, cytoplasmic vesicle, endomembrane system, glutamatergic synapse, membrane, nucleus, plasma membrane, postsynaptic membrane, presynapse, presynaptic membrane, synapse
Pathways: Clathrin-mediated endocytosis, Huntington disease - Mus musculus (mouse), Membrane Trafficking, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q8VD75
Entrez ID: 215114
|
Does Knockout of Dnm2 in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 616
|
Knockout
|
Dnm2
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Dnm2 (dynamin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, Golgi to plasma membrane transport, actin filament bundle organization, aorta development, autophagy, cellular response to dopamine, centrosome cycle, coronary vasculature development, endocytosis, macropinocytosis, membrane tubulation, negative regulation of membrane tubulation, negative regulation of non-motile cilium assembly, negative regulation of transforming growth factor beta receptor signaling pathway, neuron projection morphogenesis, phagocytosis, positive regulation of clathrin-dependent endocytosis, positive regulation of endocytosis, positive regulation of lamellipodium assembly, positive regulation of nitric oxide biosynthetic process, positive regulation of phagocytosis, positive regulation of substrate adhesion-dependent cell spreading, postsynaptic endocytosis, protein polymerization, receptor internalization, receptor-mediated endocytosis, regulation of Golgi organization, regulation of Rac protein signal transduction, regulation of axon extension, stress fiber assembly, synaptic vesicle budding from presynaptic endocytic zone membrane, synaptic vesicle endocytosis, transferrin transport, ventricular septum development, vesicle scission; MF: D2 dopamine receptor binding, GTP binding, GTPase activity, SH3 domain binding, WW domain binding, hydrolase activity, microtubule binding, nitric-oxide synthase binding, nucleotide binding, phosphatidylinositol 3-kinase regulatory subunit binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein kinase binding, protein serine/threonine kinase binding, protein-containing complex binding; CC: Golgi apparatus, Golgi membrane, anchoring junction, cell junction, cell projection, centriole, centrosome, clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endosome, glutamatergic synapse, growth cone, lamellipodium, membrane, microtubule, midbody, neuron projection, perinuclear region of cytoplasm, phagocytic cup, phagocytic vesicle membrane, photoreceptor inner segment, plasma membrane, podosome, postsynaptic density, postsynaptic density, intracellular component, postsynaptic endocytic zone, postsynaptic membrane, presynapse, protein-containing complex, recycling endosome, ruffle membrane, synapse, trans-Golgi network, uropod
Pathways: Adaptive Immune System, Adherens junctions interactions, Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Clathrin-mediated endocytosis, Degradation of CDH1, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Golgi Associated Vesicle Biogenesis, Immune System, Innate Immune System, L1CAM interactions, Lysosome Vesicle Biogenesis, MHC class II antigen presentation, Membrane Trafficking, Metabolism, Metabolism of nitric oxide: NOS3 activation and regulation, NOSTRIN mediated eNOS trafficking, Nervous system development, Phospholipase D signaling pathway - Mus musculus (mouse), Recycling pathway of L1, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Salmonella infection - Mus musculus (mouse), Synaptic vesicle cycle - Mus musculus (mouse), Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Vesicle-mediated transport, cyclic AMP biosynthesis, trans-Golgi Network Vesicle Budding
UniProt: P39054
Entrez ID: 13430
|
Does Knockout of Gusb in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 2,187
|
Knockout
|
Gusb
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Gusb (glucuronidase, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, aorta development, articular cartilage development, autophagy, bone development, bone growth, bone morphogenesis, bone resorption, canonical NF-kappaB signal transduction, carbohydrate metabolic process, cell population proliferation, chondrocyte hypertrophy, chondroitin sulfate proteoglycan catabolic process, cranial skeletal system development, endochondral ossification, energy homeostasis, gene expression, growth plate cartilage development, growth plate cartilage morphogenesis, heparan sulfate proteoglycan catabolic process, homeostasis of number of cells, hyaluronan catabolic process, in utero embryonic development, inflammatory response, lysosome organization, multicellular organism growth, muscle system process, ossification, phosphatidylinositol-3-phosphate biosynthetic process, protein catabolic process, protein localization to nucleus, protein secretion, response to peptide hormone, retinoid metabolic process, skeletal system development, toll-like receptor 4 signaling pathway, tumor necrosis factor-mediated signaling pathway; MF: beta-glucuronidase activity, carbohydrate binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, protein domain specific binding, signaling receptor binding; CC: endoplasmic reticulum, extracellular space, lysosomal lumen, lysosome
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), CS/DS degradation, Chondroitin sulfate/dermatan sulfate metabolism, Drug metabolism - other enzymes - Mus musculus (mouse), Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, Hyaluronan degradation, Hyaluronan metabolism, Immune System, Innate Immune System, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Pentose and glucuronate interconversions - Mus musculus (mouse), Porphyrin and chlorophyll metabolism - Mus musculus (mouse)
UniProt: P12265
Entrez ID: 110006
|
Does Knockout of Rsph1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Rsph1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rsph1 (radial spoke head 1 homolog (Chlamydomonas))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axoneme assembly, epithelial cilium movement involved in extracellular fluid movement, flagellated sperm motility, mating, meiotic cell cycle, microtubule-based process, spermatid development; CC: 9+2 motile cilium, axoneme, cell projection, chromosome, cilium, condensed nuclear chromosome, cytoplasm, cytoskeleton, extracellular region, meiotic spindle, motile cilium, nucleus, outer dense fiber, radial spoke, radial spoke head, radial spoke head 1, radial spoke head 3, sperm flagellum
Pathways:
UniProt: Q8VIG3
Entrez ID: 22092
|
Does Knockout of Nell2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Nell2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Nell2 (NEL-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: commissural neuron axon guidance, development of secondary female sexual characteristics, fertilization, neurogenesis, neuron cellular homeostasis, positive regulation of hormone secretion, regulation of growth; MF: calcium ion binding, heparin binding, identical protein binding, metal ion binding, protein binding, protein kinase C binding; CC: cytoplasm, dendrite, extracellular region, extracellular space, perikaryon
Pathways:
UniProt: Q61220
Entrez ID: 54003
|
Does Knockout of Vmn1r174 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Vmn1r174
|
response to virus
|
Microglial Cell Line
|
Gene: Vmn1r174 (vomeronasal 1 receptor 174)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: E9PYW5
Entrez ID: 404291
|
Does Knockout of Diaph2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Diaph2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Diaph2 (diaphanous related formin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament polymerization, axon midline choice point recognition, cell differentiation, ephrin receptor signaling pathway, intracellular protein localization, multicellular organismal locomotion, negative regulation of cellular component organization, negative regulation of neuron projection regeneration, neuron projection retraction, oogenesis; MF: actin binding, protein binding, small GTPase binding; CC: actin filament, endoplasmic reticulum, nucleolus
Pathways: RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHOD GTPase cycle, RHOF GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O70566
Entrez ID: 54004
|
Does Knockout of Pqbp1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Pqbp1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Pqbp1 (polyglutamine binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, activation of innate immune response, alternative mRNA splicing, via spliceosome, cellular response to exogenous dsRNA, defense response to virus, immune system process, innate immune response, mRNA processing, neuron projection development, positive regulation of defense response to virus by host, positive regulation of non-motile cilium assembly, positive regulation of type I interferon production, regulation of RNA splicing, regulation of dendrite morphogenesis; MF: GTPase binding, double-stranded DNA binding, ribonucleoprotein complex binding; CC: centrosome, ciliary basal body, ciliary base, cilium, cytoplasm, cytoplasmic stress granule, cytosol, microtubule cytoskeleton, neuronal ribonucleoprotein granule, nuclear body, nuclear speck, nucleoplasm, nucleus, plasma membrane bounded cell projection
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q91VJ5
Entrez ID: 54633
|
Does Knockout of Cops5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,268
|
Knockout
|
Cops5
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cops5 (COP9 signalosome subunit 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exosomal secretion, negative regulation of apoptotic process, positive regulation of DNA-binding transcription factor activity, positive regulation of transcription by RNA polymerase II, protein deneddylation, proteolysis, regulation of DNA-templated transcription, regulation of IRE1-mediated unfolded protein response, regulation of JNK cascade, regulation of cell cycle; MF: deNEDDylase activity, enzyme binding, hydrolase activity, macrophage migration inhibitory factor binding, metal ion binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, protein binding, transcription coactivator activity; CC: COP9 signalosome, chromatin, cytoplasm, cytoplasmic vesicle, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm, synapse, synaptic vesicle, transcription regulator complex
Pathways: Adaptive Immune System, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Co-inhibition by PD-1, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Global Genome Nucleotide Excision Repair (GG-NER), Immune System, Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: O35864
Entrez ID: 26754
|
Does Knockout of Ice1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Ice1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ice1 (interactor of little elongation complex ELL subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of intracellular protein transport, positive regulation of protein-containing complex assembly, positive regulation of transcription by RNA polymerase III, snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III; MF: protein-macromolecule adaptor activity; CC: Cajal body, euchromatin, histone locus body, nuclear body, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: E9Q286
Entrez ID: 218333
|
Does Knockout of Gm28465 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Gm28465
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm28465 (predicted gene 28465)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Vmn2r18 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Vmn2r18
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Vmn2r18 (vomeronasal 2, receptor 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2W3Z9, A0A8V5KY92, A0A3B2WCD9, A0A3B2WB67, A0A3B2WDC6
Entrez ID: 632671
|
Does Knockout of Mrps22 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Mrps22
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Mrps22 (mitochondrial ribosomal protein S22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CXW2
Entrez ID: 64655
|
Does Knockout of Cdk7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Cdk7
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Cdk7 (cyclin dependent kinase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II promoter clearance, RNA polymerase II transcription initiation surveillance, cell division, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription pausing by RNA polymerase II; MF: ATP binding, ATP-dependent activity, acting on DNA, RNA polymerase II CTD heptapeptide repeat S5 kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: CAK-ERCC2 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, fibrillar center, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, transcription factor TFIIH core complex, transcription factor TFIIH holo complex, transcription factor TFIIK complex
Pathways: Basal transcription factors - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Repair, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, G1 Phase, G1/S Transition, G2/M Transition, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, RUNX1 regulates transcription of genes involved in differentiation of HSCs, S Phase, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, mRNA Capping
UniProt: Q03147
Entrez ID: 12572
|
Does Knockout of Ccr10 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Ccr10
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Ccr10 (C-C motif chemokine receptor 10)
Type: protein-coding
Summary: Enables C-C chemokine receptor activity. Acts upstream of or within chemotaxis and positive regulation of cytosolic calcium ion concentration. Predicted to be located in cell surface; endoplasmic reticulum; and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CCR10 (C-C motif chemokine receptor 10). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, immune response, positive regulation of cytosolic calcium ion concentration, signal transduction; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, chemokine receptor activity, protein binding; CC: cell surface, endoplasmic reticulum, external side of plasma membrane, membrane, plasma membrane
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Intestinal immune network for IgA production - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q9JL21
Entrez ID: 12777
|
Does Knockout of Anpep in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Anpep
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Anpep (alanyl aminopeptidase, membrane)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, angiotensin maturation, cell differentiation, peptide catabolic process, protein processing, proteolysis; MF: alanyl aminopeptidase activity, aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, peptide binding, zinc ion binding; CC: brush border membrane, endoplasmic reticulum-Golgi intermediate compartment, external side of plasma membrane, extracellular exosome, extracellular space, membrane, plasma membrane
Pathways: γ-glutamyl cycle, Glutathione metabolism - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation, Renin-angiotensin system - Mus musculus (mouse), glutathione-mediated detoxification
UniProt: P97449
Entrez ID: 16790
|
Does Knockout of Nwd2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,683
|
Knockout
|
Nwd2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nwd2 (NACHT and WD repeat domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, synapse
Pathways:
UniProt: Q6P5U7
Entrez ID: 319807
|
Does Knockout of Pds5a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Pds5a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pds5a (PDS5 cohesin associated factor A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, cell division, embryonic skeletal system morphogenesis, enteric nervous system development, heart morphogenesis, lens development in camera-type eye, metanephros development, mitotic sister chromatid cohesion, negative regulation of DNA replication, neuroblast migration, roof of mouth development; CC: chromatin, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: A0A0J9YV33, E9QPI5
Entrez ID: 71521
|
Does Knockout of Mbnl2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Mbnl2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mbnl2 (muscleblind like splicing factor 2)
Type: protein-coding
Summary: Predicted to enable RNA binding activity and sequence-specific double-stranded DNA binding activity. Acts upstream of or within regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and retina. Used to study myotonic disease. Orthologous to human MBNL2 (muscleblind like splicing regulator 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q8C181
Entrez ID: 105559
|
Does Knockout of Slc25a2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Slc25a2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc25a2 (solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-arginine transmembrane transport, L-lysine transmembrane transport, L-ornithine transmembrane transport, mitochondrial L-ornithine transmembrane transport, ornithine metabolic process; MF: L-arginine transmembrane transporter activity, L-lysine transmembrane transporter activity, L-ornithine transmembrane transporter activity, antiporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Metabolism, Metabolism of amino acids and derivatives, Urea cycle
UniProt: Q99ML6
Entrez ID: 83885
|
Does Knockout of Clk2 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,411
|
Knockout
|
Clk2
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Clk2 (CDC-like kinase 2)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in negative regulation of gluconeogenesis and protein autophosphorylation. Acts upstream of or within peptidyl-tyrosine phosphorylation and response to retinoic acid. Located in nucleus. Is expressed in several structures, including brain; genitourinary system; liver; retina; and thyroid gland. Orthologous to human CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of gluconeogenesis, protein autophosphorylation, protein phosphorylation, regulation of RNA splicing, response to ionizing radiation, response to retinoic acid; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: O35491
Entrez ID: 12748
|
Does Knockout of Itpr3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Itpr3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Itpr3 (inositol 1,4,5-triphosphate receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium ion homeostasis, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cellular response to cAMP, long-term synaptic potentiation, memory, monoatomic ion transmembrane transport, monoatomic ion transport, platelet activation, positive regulation of cytosolic calcium ion concentration, protein homotetramerization, release of sequestered calcium ion into cytosol, response to calcium ion, sensory perception of bitter taste, sensory perception of sweet taste, sensory perception of umami taste, transmembrane transport; MF: ATP binding, calcium channel activity, calcium ion binding, identical protein binding, inositol 1,3,4,5 tetrakisphosphate binding, inositol 1,4,5 trisphosphate binding, inositol 1,4,5-trisphosphate-gated calcium channel activity, inositol hexakisphosphate binding, intracellularly gated calcium channel activity, metal ion binding, monoatomic ion channel activity, nucleotide binding, phosphatidylinositol binding, protein binding, protein-containing complex binding, zinc ion binding; CC: apical part of cell, apical plasma membrane, brush border, cytoplasm, cytoplasmic side of endoplasmic reticulum membrane, cytoplasmic vesicle, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, neuronal cell body, nuclear envelope, nuclear outer membrane, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, presynapse, receptor complex, sarcoplasmic reticulum, secretory granule membrane, transport vesicle membrane
Pathways: Adaptive Immune System, Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Apelin signaling pathway - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cellular senescence - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Effects of PIP2 hydrolysis, Elevation of cytosolic Ca2+ levels, Estrogen signaling pathway - Mus musculus (mouse), G alpha (q) signalling events, GPCR downstream signalling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glutamatergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Ion homeostasis, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Metabolism, Muscle contraction, NOD-like receptor signaling pathway - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet calcium homeostasis, Platelet homeostasis, Prion disease - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of insulin secretion, Renin secretion - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Taste transduction - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P70227
Entrez ID: 16440
|
Does Knockout of Pde6a in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Pde6a
|
cell cycle progression
|
breast epithelium
|
Gene: Pde6a (phosphodiesterase 6A, cGMP-specific, rod, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cAMP/PKA signal transduction, photoreceptor cell maintenance, retina development in camera-type eye, signal transduction, visual perception; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity; CC: cell projection, membrane, photoreceptor outer segment, photoreceptor outer segment membrane, plasma membrane
Pathways: Phototransduction - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), cyclic GMP biosynthesis
UniProt: F6UDG9, Q8K0A8
Entrez ID: 225600
|
Does Knockout of Dnajc19 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Dnajc19
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dnajc19 (DnaJ heat shock protein family (Hsp40) member C19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: genitalia development, protein import into mitochondrial matrix, protein transport, regulation of cardiolipin metabolic process, visual perception; MF: ATPase activator activity, protein binding; CC: PAM complex, Tim23 associated import motor, inner mitochondrial membrane protein complex, matrix side of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CQV7
Entrez ID: 67713
|
Does Knockout of Wrap73 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Wrap73
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Wrap73 (WD repeat containing, antisense to Trp73)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, mitotic spindle assembly, positive regulation of non-motile cilium assembly; CC: MWP complex, centrosome, ciliary basal body, cytoplasm, cytoskeleton, microtubule organizing center
Pathways:
UniProt: Q9JM98
Entrez ID: 59002
|
Does Knockout of Defb38 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Defb38
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Defb38 (defensin beta 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, innate immune response in mucosa, response to bacterium; CC: extracellular region, extracellular space
Pathways:
UniProt: Q7TNV7
Entrez ID: 360212
|
Does Knockout of Slc25a18 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Slc25a18
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc25a18 (solute carrier family 25 (mitochondrial carrier), member 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-aspartate transmembrane transport, L-glutamate transmembrane transport, aspartate transmembrane transport, malate-aspartate shuttle, proton transmembrane transport, transmembrane transport; MF: L-aspartate transmembrane transporter activity, L-glutamate transmembrane transporter activity, amino acid:proton symporter activity, symporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Malate-aspartate shuttle, Metabolism, Respiratory electron transport, SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Transport of small molecules
UniProt: Q9DB41
Entrez ID: 71803
|
Does Knockout of Ccdc187 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Ccdc187
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ccdc187 (coiled-coil domain containing 187)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, microtubule anchoring; MF: microtubule binding, molecular_function
Pathways:
UniProt: Q8C5V8
Entrez ID: 329366
|
Does Knockout of Hibadh in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Hibadh
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Hibadh (3-hydroxyisobutyrate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-valine catabolic process, branched-chain amino acid catabolic process; MF: 3-hydroxyisobutyrate dehydrogenase activity, NAD binding, NADP binding, oxidoreductase activity; CC: mitochondrion
Pathways: Branched-chain amino acid catabolism, Metabolism, Metabolism of amino acids and derivatives, Valine, leucine and isoleucine degradation - Mus musculus (mouse), valine degradation, valine degradation I
UniProt: Q99L13
Entrez ID: 58875
|
Does Knockout of Tmem52b in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Tmem52b
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Tmem52b (transmembrane protein 52B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q0VBF2
Entrez ID: 330428
|
Does Knockout of Bfar in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Bfar
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Bfar (bifunctional apoptosis regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRE1-mediated unfolded protein response, apoptotic process, negative regulation of IRE1-mediated unfolded protein response, negative regulation of apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein K63-linked ubiquitination, protein autoubiquitination, protein polyubiquitination, ubiquitin-dependent protein catabolic process; MF: caspase binding, metal ion binding, protein-macromolecule adaptor activity, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8R079
Entrez ID: 67118
|
Does Knockout of Cnnm1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Cnnm1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cnnm1 (cyclin M1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: magnesium ion homeostasis, monoatomic ion transport, transmembrane transport; CC: dendrite, membrane, neuronal cell body, plasma membrane
Pathways:
UniProt: Q0GA42
Entrez ID: 83674
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.