prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Lce3e in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Lce3e
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lce3e (late cornified envelope 3E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, epidermis development, keratinization
Pathways:
UniProt: F8VQJ0
Entrez ID: 69514
|
Does Knockout of Nars2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Nars2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nars2 (asparaginyl-tRNA synthetase 2 (mitochondrial)(putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: asparaginyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, asparagine-tRNA ligase activity, ligase activity, nucleic acid binding, nucleotide binding; CC: cytosol, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8BGV0
Entrez ID: 244141
|
Does Knockout of Il22ra2 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Il22ra2
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Il22ra2 (interleukin 22 receptor, alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, interleukin-22-mediated signaling pathway, negative regulation of inflammatory response; MF: cytokine receptor activity, interleukin-22 binding, interleukin-22 receptor activity, protein binding; CC: cytosol, extracellular region, plasma membrane
Pathways: Cytokine Signaling in Immune system, Immune System, Interleukin-20 family signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Signaling by Interleukins
UniProt: Q80XF5
Entrez ID: 237310
|
Does Knockout of Nuak1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Nuak1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Nuak1 (NUAK family, SNF1-like kinase, 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cell adhesion, protein phosphorylation, regulation of cell adhesion, regulation of cellular senescence; MF: ATP binding, kinase activity, nucleotide binding, p53 binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, fibrillar center, microtubule cytoskeleton, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q641K5
Entrez ID: 77976
|
Does Knockout of Bcl2l12 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Bcl2l12
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bcl2l12 (BCL2 like 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, negative regulation of cellular senescence, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of transcription by RNA polymerase II, regulation of apoptotic process; CC: nucleus
Pathways:
UniProt: A0A140LHT8, Q9D3J3, A0A140LHC2, A0A140LIT0
Entrez ID: 75736
|
Does Knockout of Plk5 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Plk5
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Plk5 (polo like kinase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cell differentiation, cell division, cellular response to growth factor stimulus, defense response to tumor cell, mitotic spindle organization, negative regulation of cell population proliferation, positive regulation of neuron projection development, regulation of G1/S transition of mitotic cell cycle, regulation of apoptotic process; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding; CC: centrosome, cytoplasm, kinetochore, nucleolus, nucleus, spindle pole
Pathways:
UniProt: Q4FZD7
Entrez ID: 216166
|
Does Knockout of Lcn4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Lcn4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lcn4 (lipocalin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, odorant binding, pheromone binding, small molecule binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q62472
Entrez ID: 16821
|
Does Knockout of Csnk2a1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Csnk2a1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Csnk2a1 (casein kinase 2, alpha 1 polypeptide)
Type: protein-coding
Summary: Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: Wnt signaling pathway, apoptotic process, cerebral cortex development, double-strand break repair, liver regeneration, negative regulation of apoptotic signaling pathway, negative regulation of double-strand break repair via homologous recombination, positive regulation of Wnt signaling pathway, positive regulation of aggrephagy, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of protein catabolic process, regulation of cell cycle, regulation of chromosome separation, regulation of protein localization to plasma membrane, response to testosterone, rhythmic process; MF: ATP binding, beta-catenin binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein phosphatase regulator activity, protein serine kinase activity, protein serine/threonine kinase activity, ribonucleoprotein complex binding, transferase activity; CC: PML body, PcG protein complex, Sin3-type complex, chromatin, cytosol, nucleoplasm, nucleus, protein kinase CK2 complex
Pathways: Adaptive Immune System, Adherens junction - Mus musculus (mouse), Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Autophagy, Axon guidance, Cell Cycle, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chaperonin-mediated protein folding, Co-inhibition by PD-1, Condensation of Prometaphase Chromosomes, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Developmental Biology, Gene expression (Transcription), Generic Transcription Pathway, Glycerophospholipid biosynthesis, Immune System, Intracellular signaling by second messengers, L1CAM interactions, M Phase, Macroautophagy, Measles - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of proteins, Mitophagy, Mitophagy - animal - Mus musculus (mouse), Mitotic Prometaphase, NF-kappa B signaling pathway - Mus musculus (mouse), Nervous system development, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PIP3 activates AKT signaling, PTEN Regulation, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phospholipid metabolism, Prion disease - Mus musculus (mouse), Protein folding, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Receptor Mediated Mitophagy, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), SPOP-mediated proteasomal degradation of PD-L1(CD274), Selective autophagy, Signal Transduction, Signal transduction by L1, Signaling by WNT, Synthesis of PC, TCF dependent signaling in response to WNT, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, WNT mediated activation of DVL, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q60737
Entrez ID: 12995
|
Does Knockout of Tacr1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,185
|
Knockout
|
Tacr1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tacr1 (tachykinin receptor 1)
Type: protein-coding
Summary: This gene encodes the receptor for the tachykinin, substance P, also referred to as neurokinin 1. This gene belongs to a gene family of tachykinin receptors which are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This receptor has been associated with nitric oxide formation, and it has been localized to cholinergic and nitrergic neurons as well as on smooth muscle cells. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, aggressive behavior, angiotensin-mediated drinking behavior, associative learning, behavioral response to pain, eating behavior, learning or memory, long-term memory, operant conditioning, positive regulation of action potential, positive regulation of blood pressure, positive regulation of cytosolic calcium ion concentration, positive regulation of epithelial cell migration, positive regulation of epithelial cell proliferation, positive regulation of flagellated sperm motility, positive regulation of hormone secretion, positive regulation of leukocyte migration, positive regulation of lymphocyte proliferation, positive regulation of ossification, positive regulation of stress fiber assembly, positive regulation of synaptic transmission, GABAergic, positive regulation of synaptic transmission, cholinergic, positive regulation of uterine smooth muscle contraction, positive regulation of vascular permeability, positive regulation of vasoconstriction, regulation of blood pressure, regulation of smooth muscle cell migration, regulation of smooth muscle cell proliferation, regulation of uterine smooth muscle contraction, response to auditory stimulus, response to electrical stimulus, response to estradiol, response to ethanol, response to hormone, response to nicotine, response to ozone, response to pain, response to progesterone, signal transduction, smooth muscle contraction involved in micturition, sperm ejaculation, tachykinin receptor signaling pathway; MF: G protein-coupled receptor activity, substance P receptor activity, tachykinin receptor activity; CC: cell body, cell periphery, cell surface, dendrite, membrane, plasma membrane, postsynaptic membrane, sperm flagellum, sperm head, sperm midpiece
Pathways: Calcium signaling pathway - Mus musculus (mouse), Cargo recognition for clathrin-mediated endocytosis, Class A/1 (Rhodopsin-like receptors), Clathrin-mediated endocytosis, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Membrane Trafficking, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Tachykinin receptors bind tachykinins, Vesicle-mediated transport
UniProt: P30548
Entrez ID: 21336
|
Does Knockout of Fkbp6 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Fkbp6
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Fkbp6 (FK506 binding protein 6)
Type: protein-coding
Summary: This gene is a member of the FK506-binding protein (Fkbp) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to Hsp90 as a co-chaperone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: cell differentiation, meiotic cell cycle, piRNA processing, positive regulation of viral genome replication, protein folding, regulatory ncRNA-mediated gene silencing, spermatogenesis, transposable element silencing by piRNA-mediated DNA methylation; MF: Hsp90 protein binding, identical protein binding, peptidyl-prolyl cis-trans isomerase activity; CC: chromosome, cytoplasm, cytosol, fibrillar center, intercellular bridge, microtubule cytoskeleton, nucleoplasm, nucleus, synaptonemal complex
Pathways:
UniProt: Q91XW8
Entrez ID: 94244
|
Does Knockout of Mir763 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Mir763
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Mir763 (microRNA 763)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 791076
|
Does Knockout of Steap1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Steap1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Steap1 (six transmembrane epithelial antigen of the prostate 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: heme binding, metal ion binding; CC: endosome, endosome membrane, membrane, plasma membrane
Pathways: Mineral absorption - Mus musculus (mouse)
UniProt: Q9CWR7
Entrez ID: 70358
|
Does Knockout of Hus1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,531
|
Knockout
|
Hus1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Hus1 (HUS1 checkpoint clamp component)
Type: protein-coding
Summary: This gene encodes a component of a cell cycle checkpoint complex that causes cell cycle arrest in response to bulky DNA lesions and DNA replication blockage. Together with the proteins Rad9 and Rad1, the encoded protein forms a heterotrimeric complex known as the 9-1-1 complex. Mice lacking the encoded protein develop spontaneous chromosomal abnormalities resulting in embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, cellular response to ionizing radiation, double-strand break repair via homologous recombination, embryo development ending in birth or egg hatching, meiotic DNA integrity checkpoint signaling, mitotic DNA replication checkpoint signaling, mitotic intra-S DNA damage checkpoint signaling, nucleotide-excision repair, regulation of protein phosphorylation, response to UV, response to radiation, telomere maintenance; CC: checkpoint clamp complex, cytoplasm, cytosol, nucleolus, nucleus, site of double-strand break
Pathways: Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, Cellular senescence - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q8BQY8
Entrez ID: 15574
|
Does Knockout of Ptbp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Ptbp1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ptbp1 (polypyrimidine tract binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRES-dependent viral translational initiation, RNA splicing, gene expression, mRNA processing, negative regulation of RNA splicing, negative regulation of gene expression, negative regulation of mRNA metabolic process, negative regulation of mRNA splicing, via spliceosome, negative regulation of muscle cell differentiation, negative regulation of neuron differentiation, neurogenesis, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of transcription by RNA polymerase II, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, regulation of cell differentiation; MF: RNA binding, mRNA binding, nucleic acid binding, pre-mRNA binding, protein binding, regulatory region RNA binding, sequence-specific DNA binding, single-stranded DNA binding, single-stranded DNA endodeoxyribonuclease activity; CC: neuron projection terminus, nucleus
Pathways: FGFR2 alternative splicing, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P17225
Entrez ID: 19205
|
Does Knockout of Cct8 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Cct8
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cct8 (chaperonin containing TCP1 subunit 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, cell projection, centrosome, chaperonin-containing T-complex, cilium, cytoplasm, cytoskeleton, microtubule, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Protein folding
UniProt: P42932
Entrez ID: 12469
|
Does Knockout of Gpm6b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Gpm6b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gpm6b (glycoprotein m6b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, central nervous system myelination, extracellular matrix assembly, negative regulation of protein localization to cell surface, negative regulation of serotonin uptake, ossification, positive regulation of bone mineralization, protein transport, regulation of actin cytoskeleton organization, regulation of focal adhesion assembly; CC: membrane, membrane raft, myelin sheath, plasma membrane
Pathways:
UniProt: P35803
Entrez ID: 14758
|
Does Knockout of Hmgcl in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 1,521
|
Knockout
|
Hmgcl
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Hmgcl (3-hydroxy-3-methylglutaryl-Coenzyme A lyase)
Type: protein-coding
Summary: Predicted to enable several functions, including anion binding activity; hydroxymethylglutaryl-CoA lyase activity; and metal ion binding activity. Acts upstream of or within mitochondrion organization. Located in mitochondrion. Is expressed in alimentary system; cranium; and liver. Human ortholog(s) of this gene implicated in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency and amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: L-leucine catabolic process, acyl-CoA metabolic process, ketone body biosynthetic process, lipid metabolic process, mitochondrion organization; MF: carboxylic acid binding, catalytic activity, fatty-acyl-CoA binding, hydroxymethylglutaryl-CoA lyase activity, lyase activity, magnesium ion binding, manganese ion binding, metal ion binding, oxo-acid-lyase activity, structural molecule activity; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrion, peroxisome, protein-containing complex
Pathways: Butanoate metabolism - Mus musculus (mouse), Ketone body metabolism, Leucine Catabolism, Metabolism, Metabolism of lipids, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization, Synthesis of Ketone Bodies, Valine, leucine and isoleucine degradation - Mus musculus (mouse), ketogenesis, leucine degradation I
UniProt: P38060
Entrez ID: 15356
|
Does Knockout of Cdc42ep4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Cdc42ep4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cdc42ep4 (CDC42 effector protein 4)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Acts upstream of or within Rho protein signal transduction and cellular response to type II interferon. Located in phagocytic vesicle. Is expressed in several structures, including central nervous system; forelimb bud; heart valve; lung; and retina. Orthologous to human CDC42EP4 (CDC42 effector protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Rho protein signal transduction, cellular response to type II interferon, positive regulation of actin filament polymerization, positive regulation of pseudopodium assembly, regulation of cell shape; MF: protein binding, small GTPase binding; CC: actin cytoskeleton, adherens junction, cytoplasm, cytoskeleton, endomembrane system, membrane, microtubule cytoskeleton, phagocytic vesicle, plasma membrane
Pathways: RAC1 GTPase cycle, RAC2 GTPase cycle, RHO GTPase cycle, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9JM96
Entrez ID: 56699
|
Does Knockout of Cd200r1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Cd200r1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Cd200r1 (CD200 receptor 1)
Type: protein-coding
Summary: Enables signaling receptor activity. Predicted to be involved in several processes, including negative regulation of interleukin-6 production; negative regulation of mononuclear cell migration; and negative regulation of neuroinflammatory response. Located in external side of plasma membrane. Is expressed in central nervous system; liver lobe; retina; and thymus primordium. Orthologous to several human genes including CD200R1 (CD200 receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: heterotypic cell-cell adhesion, negative regulation of T cell migration, negative regulation of interleukin-6 production, negative regulation of macrophage migration, negative regulation of neuroinflammatory response, regulation of neuroinflammatory response; MF: protein binding, protein binding involved in heterotypic cell-cell adhesion, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, receptor complex
Pathways: Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse)
UniProt: Q9ES57
Entrez ID: 57781
|
Does Knockout of Gabrg1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Gabrg1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gabrg1 (gamma-aminobutyric acid type A receptor subunit gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemical synaptic transmission, chloride transmembrane transport, chloride transport, gamma-aminobutyric acid signaling pathway, inhibitory synapse assembly, monoatomic ion transmembrane transport, monoatomic ion transport, synaptic transmission, GABAergic; MF: GABA receptor binding, GABA-A receptor activity, GABA-gated chloride ion channel activity, benzodiazepine receptor activity, chloride channel activity, extracellular ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, transmembrane signaling receptor activity; CC: GABA-A receptor complex, chloride channel complex, dendrite membrane, membrane, plasma membrane, postsynapse, postsynaptic membrane, receptor complex, synapse
Pathways: GABAergic synapse - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nicotine addiction - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse)
UniProt: Q9R0Y8
Entrez ID: 14405
|
Does Knockout of Zfp141 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Zfp141
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp141 (zinc finger protein 141)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: A0A0U1RNI1, G3UY09
Entrez ID: 434178
|
Does Knockout of Zc3h12b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Zc3h12b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zc3h12b (zinc finger CCCH-type containing 12B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA endonuclease activity, endonuclease activity, hydrolase activity, mRNA binding, metal ion binding, nuclease activity, zinc ion binding; CC: cytoplasmic ribonucleoprotein granule, nucleus
Pathways:
UniProt: Q3UYJ7, G3X9I7, A2BE29, S4R1K0
Entrez ID: 547176
|
Does Knockout of Adcy9 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Adcy9
|
cell cycle progression
|
breast epithelium
|
Gene: Adcy9 (adenylate cyclase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating adrenergic receptor signaling pathway, cAMP biosynthetic process, cyclic nucleotide biosynthetic process, in utero embryonic development, intracellular signal transduction; MF: ATP binding, adenylate cyclase activity, lyase activity, metal ion binding, nucleotide binding, phosphorus-oxygen lyase activity; CC: axon, ciliary basal body, cilium, cytosol, dendrite, membrane, plasma membrane
Pathways: Activation of GABAB receptors, Adenylate cyclase activating pathway, Adenylate cyclase inhibitory pathway, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Bile secretion - Mus musculus (mouse), Ca-dependent events, CaM pathway, Calcium signaling pathway - Mus musculus (mouse), Calmodulin induced events, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), DAG and IP3 signaling, Dilated cardiomyopathy - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), G alpha (i) signalling events, G alpha (z) signalling events, G-protein mediated events, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hedgehog 'off' state, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Intracellular signaling by second messengers, Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Oocyte meiosis - Mus musculus (mouse), Opioid Signalling, Ovarian steroidogenesis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PKA activation, PKA-mediated phosphorylation of CREB, PLC beta mediated events, Pancreatic secretion - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by Hedgehog, Thermogenesis - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Transmission across Chemical Synapses, Vascular smooth muscle contraction - Mus musculus (mouse), Vasopressin-regulated water reabsorption - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), cyclic AMP biosynthesis
UniProt: P51830
Entrez ID: 11515
|
Does Knockout of Slc7a1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Slc7a1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc7a1 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-amino acid transport, L-arginine import across plasma membrane, L-arginine transmembrane transport, L-histidine import across plasma membrane, L-lysine transmembrane transport, L-ornithine transmembrane transport, amino acid import across plasma membrane, amino acid transport, lysine transport, ornithine transport, positive regulation of T cell proliferation, regulation of TOR signaling, symbiont entry into host cell, transmembrane transport; MF: L-arginine transmembrane transporter activity, L-histidine transmembrane transporter activity, L-lysine transmembrane transporter activity, L-ornithine transmembrane transporter activity, amino acid transmembrane transporter activity, basic amino acid transmembrane transporter activity, protein binding, transmembrane transporter activity, virus receptor activity; CC: apical plasma membrane, basal plasma membrane, basolateral plasma membrane, membrane, plasma membrane, protein-containing complex
Pathways: Amino acid transport across the plasma membrane, MicroRNAs in cancer - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules
UniProt: Q09143
Entrez ID: 11987
|
Does Knockout of Zfp710 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Zfp710
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp710 (zinc finger protein 710)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q3U288
Entrez ID: 209225
|
Does Knockout of Ssrp1 in Lung Cancer Cell Line causally result in tumorigenicity?
| 0
| 1,781
|
Knockout
|
Ssrp1
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Ssrp1 (structure specific recognition protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, nucleosome assembly, nucleosome disassembly, regulation of chromatin organization; MF: DNA binding, chromatin binding, histone binding, nucleosome binding; CC: FACT complex, chromosome, nucleolus, nucleus
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q08943
Entrez ID: 20833
|
Does Knockout of Cyb5d2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Cyb5d2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cyb5d2 (cytochrome b5 domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development, positive regulation of neuron differentiation; CC: endomembrane system, extracellular region, membrane
Pathways:
UniProt: Q5SSH8
Entrez ID: 192986
|
Does Knockout of Pof1b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Pof1b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pof1b (premature ovarian failure 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament organization, bicellular tight junction assembly, epithelial cell morphogenesis; MF: actin binding, actin filament binding; CC: actin filament, adherens junction, anchoring junction, bicellular tight junction, desmosome
Pathways:
UniProt: Q8K4L4
Entrez ID: 69693
|
Does Knockout of Casc3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Casc3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Casc3 (exon junction complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, intracellular mRNA localization, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translation; MF: RNA binding, enzyme binding, identical protein binding, mRNA binding, protein binding, ubiquitin protein ligase binding; CC: U2-type catalytic step 1 spliceosome, cell projection, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, dendrite, exon-exon junction complex, nuclear membrane, nuclear speck, nucleus, perinuclear region of cytoplasm, ribonucleoprotein complex, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8K3W3
Entrez ID: 192160
|
Does Knockout of Tgm2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Tgm2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tgm2 (transglutaminase 2, C polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, apoptotic cell clearance, blood vessel remodeling, bone development, branching involved in salivary gland morphogenesis, cellular response to cocaine, cellular response to dopamine, cellular response to serotonin, chromatin remodeling, dopamine secretion, gene expression, negative regulation of endoplasmic reticulum calcium ion concentration, peptide cross-linking, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of GTPase activity, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell adhesion, positive regulation of mitochondrial calcium ion concentration, positive regulation of neurogenesis, positive regulation of small GTPase mediated signal transduction, positive regulation of smooth muscle cell proliferation, positive regulation of sprouting angiogenesis, protein deamination, protein homooligomerization, proteolysis, regulation of apoptotic cell clearance, regulation of apoptotic process, salivary gland cavitation; MF: GTP binding, acyltransferase activity, calcium ion binding, histone dopaminyltransferase activity, histone serotonyltransferase activity, hydrolase activity, identical protein binding, metal ion binding, nucleotide binding, peptidase activity, peptide dopaminyltransferase activity, peptide histaminyltransferase activity, peptide noradrenalinyltransferase activity, peptide serotonyltransferase activity, phospholipase binding, protein domain specific binding, protein-glutamine gamma-glutamyltransferase activity, protein-glutamine glutaminase activity, transaminase activity, transferase activity; CC: chromatin, chromosome, cytoplasm, cytosol, endoplasmic reticulum, extracellular matrix, extracellular region, membrane, mitochondrion, nucleosome, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Huntington disease - Mus musculus (mouse)
UniProt: P21981
Entrez ID: 21817
|
Does Knockout of Disp1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Disp1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Disp1 (dispatched RND transporter family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: determination of left/right symmetry, diaphragm development, dorsal/ventral pattern formation, embryonic pattern specification, patched ligand maturation, peptide transport, smoothened signaling pathway; CC: membrane
Pathways: Hedgehog signaling pathway - Mus musculus (mouse)
UniProt: Q3TDN0
Entrez ID: 68897
|
Does Knockout of Acin1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Acin1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Acin1 (apoptotic chromatin condensation inducer 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic chromosome condensation, apoptotic process, erythrocyte differentiation, mRNA processing, negative regulation of mRNA splicing, via spliceosome, positive regulation of apoptotic process, positive regulation of monocyte differentiation; CC: ASAP complex, cytosol, exon-exon junction complex, nuclear lumen, nuclear speck, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9JIX8
Entrez ID: 56215
|
Does Knockout of Bcl2l12 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Bcl2l12
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Bcl2l12 (BCL2 like 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, negative regulation of cellular senescence, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of transcription by RNA polymerase II, regulation of apoptotic process; CC: nucleus
Pathways:
UniProt: A0A140LHT8, Q9D3J3, A0A140LHC2, A0A140LIT0
Entrez ID: 75736
|
Does Knockout of Iqcm in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Iqcm
|
response to bacteria
|
renal medulla cell line
|
Gene: Iqcm (IQ motif containing M)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DAN0, Q149I8
Entrez ID: 71831
|
Does Knockout of Kiss1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Kiss1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Kiss1 (KiSS-1 metastasis-suppressor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, decidualization, generation of ovulation cycle rhythm, negative regulation of cell population proliferation, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of cytosolic calcium ion concentration, positive regulation of growth hormone secretion, positive regulation of luteinizing hormone secretion, positive regulation of synaptic transmission; MF: kisspeptin receptor binding, protein binding; CC: apical plasma membrane, extracellular region, extracellular space, neuronal cell body
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GnRH secretion - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q6Y4S4
Entrez ID: 280287
|
Does Knockout of Ip6k3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Ip6k3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ip6k3 (inositol hexaphosphate kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inositol phosphate biosynthetic process, locomotion, phosphatidylinositol metabolic process, phosphatidylinositol phosphate biosynthetic process; MF: ATP binding, inositol hexakisphosphate 5-kinase activity, inositol hexakisphosphate 6-kinase activity, inositol hexakisphosphate kinase activity, kinase activity, nucleotide binding, transferase activity; CC: cytoplasm, nucleus
Pathways: Phosphatidylinositol signaling system - Mus musculus (mouse)
UniProt: Q8BWD2
Entrez ID: 271424
|
Does Knockout of Ing3 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Ing3
|
phagocytosis
|
macrophage
|
Gene: Ing3 (inhibitor of growth family, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of apoptotic process, regulation of cell cycle, regulation of chromatin organization, regulation of double-strand break repair; MF: histone H2A acetyltransferase activity, histone H3K4me3 reader activity, histone H4 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, metal ion binding, zinc ion binding; CC: NuA4 histone acetyltransferase complex, Swr1 complex, nucleoplasm, nucleosome, nucleus, piccolo histone acetyltransferase complex
Pathways:
UniProt: Q8VEK6
Entrez ID: 71777
|
Does Knockout of Zfp112 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Zfp112
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Zfp112 (zinc finger protein 112)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q0VAW7
Entrez ID: 57745
|
Does Knockout of Acad8 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 2,474
|
Knockout
|
Acad8
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Acad8 (acyl-Coenzyme A dehydrogenase family, member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-valine catabolic process, branched-chain amino acid catabolic process, fatty acid beta-oxidation, lipid metabolic process; MF: acyl-CoA dehydrogenase activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, short-chain 2-methyl fatty acyl-CoA dehydrogenase activity; CC: mitochondrion
Pathways: Branched-chain amino acid catabolism, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitochondrial protein degradation, Valine, leucine and isoleucine degradation - Mus musculus (mouse), fatty acid β-oxidation I, valine degradation, valine degradation I
UniProt: Q9D7B6
Entrez ID: 66948
|
Does Knockout of Svop in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Svop
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Svop (SV2 related protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasmic vesicle, membrane, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways:
UniProt: Q8BFT9
Entrez ID: 68666
|
Does Knockout of Zkscan16 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Zkscan16
|
phagocytosis
|
macrophage
|
Gene: Zkscan16 (zinc finger with KRAB and SCAN domains 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: A2ALW2
Entrez ID: 100041581
|
Does Knockout of Ccl12 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Ccl12
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ccl12 (C-C motif chemokine ligand 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, antimicrobial humoral immune response mediated by antimicrobial peptide, chemokine-mediated signaling pathway, chemotaxis, eosinophil chemotaxis, immune response, inflammatory response, monocyte chemotaxis, negative regulation of leukocyte proliferation, positive regulation of cell migration, positive regulation of leukocyte migration; MF: CCR chemokine receptor binding, CCR1 chemokine receptor binding, CCR2 chemokine receptor binding, chemokine activity, cytokine activity, phospholipase activator activity, protein kinase activity; CC: extracellular region, extracellular space
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), GPCR ligand binding, Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Malaria - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Peptide ligand-binding receptors, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, TNF signaling pathway - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: Q62401
Entrez ID: 20293
|
Does Knockout of Mir6916 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Mir6916
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mir6916 (microRNA 6916)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465552
|
Does Knockout of Ndst3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Ndst3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ndst3 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3)
Type: protein-coding
Summary: Enables N-acetylglucosamine deacetylase activity and heparan sulfate N-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including exocrine system; future brain; genitourinary system; nervous system; and retina. Orthologous to human NDST3 (N-deacetylase and N-sulfotransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: heparan sulfate proteoglycan biosynthetic process, heparin proteoglycan biosynthetic process; MF: N-acetylglucosamine deacetylase activity, catalytic activity, deacetylase activity, heparan sulfate N-deacetylase activity, heparan sulfate N-sulfotransferase activity, hydrolase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q9EQH7
Entrez ID: 83398
|
Does Knockout of Zyg11a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Zyg11a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zyg11a (zyg-11 family member A, cell cycle regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A1Y7VNL1, A0A217FL76, F8WHU3
Entrez ID: 230590
|
Does Knockout of Slc39a14 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Slc39a14
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc39a14 (solute carrier family 39 (zinc transporter), member 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, cadmium ion transmembrane transport, cellular response to glucose stimulus, cellular response to insulin stimulus, chondrocyte differentiation, gluconeogenesis, import across plasma membrane, inorganic cation transmembrane transport, insulin receptor signaling pathway, intracellular monoatomic cation homeostasis, intracellular zinc ion homeostasis, iron import into cell, iron ion transmembrane transport, iron ion transport, manganese ion homeostasis, manganese ion transmembrane transport, metal ion transport, monoatomic anion transmembrane transport, monoatomic ion transport, positive regulation of G protein-coupled receptor signaling pathway, regulation of hormone levels, transmembrane transport, zinc ion import across plasma membrane, zinc ion transmembrane transport, zinc ion transport; MF: cadmium ion transmembrane transporter activity, ferrous iron transmembrane transporter activity, iron ion transmembrane transporter activity, manganese ion transmembrane transporter activity, metal ion transmembrane transporter activity, monoatomic anion:monoatomic cation symporter activity, monoatomic cation:bicarbonate symporter activity, zinc ion transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, early endosome membrane, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Ferroptosis - Mus musculus (mouse), Metal ion SLC transporters, Parkinson disease - Mus musculus (mouse), SLC-mediated transmembrane transport, Transport of small molecules, Zinc influx into cells by the SLC39 gene family, Zinc transporters
UniProt: Q75N73
Entrez ID: 213053
|
Does Knockout of Xkr7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Xkr7
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Xkr7 (X-linked Kx blood group related 7)
Type: protein-coding
Summary: Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Is active in plasma membrane. Orthologous to human XKR7 (XK related 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface; CC: membrane, plasma membrane
Pathways:
UniProt: Q5GH64
Entrez ID: 228787
|
Does Knockout of Sycp3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Sycp3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Sycp3 (synaptonemal complex protein 3)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in female meiosis sister chromatid cohesion; meiotic chromosome segregation; and spermatogenesis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; meiosis I cell cycle process; and sperm DNA condensation. Located in condensed chromosome and germ cell nucleus. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and primordial germ cell. Used to study azoospermia. Human ortholog(s) of this gene implicated in spermatogenic failure 4. Orthologous to human SYCP3 (synaptonemal complex protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, cellular response to leukemia inhibitory factor, chiasma assembly, female meiosis chromosome segregation, female meiosis chromosome separation, female meiosis sister chromatid cohesion, homologous chromosome pairing at meiosis, lateral element assembly, meiotic DNA repair synthesis, meiotic cell cycle, mitotic cell cycle, sperm DNA condensation, spermatid development, spermatogenesis, synaptonemal complex assembly; MF: DNA binding, protein binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, condensed chromosome, centromeric region, condensed nuclear chromosome, female germ cell nucleus, lateral element, male germ cell nucleus, nucleoplasm, nucleus, synaptonemal complex, transverse filament
Pathways: Homologous recombination - Mus musculus (mouse)
UniProt: P70281
Entrez ID: 20962
|
Does Knockout of Ptov1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Ptov1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ptov1 (prostate tumor over expressed gene 1)
Type: protein-coding
Summary: Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of transcription regulator complex. Is expressed in several structures, including central nervous system; gonad; lung; retina nuclear layer; and skeletal muscle. Orthologous to human PTOV1 (PTOV1 extended AT-hook containing adaptor protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cytoplasm, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, transcription regulator complex
Pathways:
UniProt: Q91VU8
Entrez ID: 84113
|
Does Knockout of Nipsnap2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Nipsnap2
|
cell proliferation
|
Regulatory T cell
|
Gene: Nipsnap2 (nipsnap homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, mitochondrion organization, mitophagy, positive regulation of high voltage-gated calcium channel activity; MF: molecular_function, protein-macromolecule adaptor activity; CC: cytoplasm, mitochondrial matrix, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: A0A0G2JEV1, Q7TMG8
Entrez ID: 14467
|
Does Knockout of Gabbr1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Gabbr1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gabbr1 (gamma-aminobutyric acid type B receptor subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, gamma-aminobutyric acid signaling pathway, negative regulation of cell population proliferation, negative regulation of dopamine secretion, negative regulation of epinephrine secretion, negative regulation of gamma-aminobutyric acid secretion, negative regulation of synaptic transmission, neuron-glial cell signaling, osteoblast differentiation, positive regulation of glutamate secretion, positive regulation of growth hormone secretion, regulation of glutamate secretion, regulation of postsynaptic membrane potential, regulation of presynaptic membrane potential, response to ethanol, response to nicotine, signal transduction, synaptic transmission, GABAergic; MF: G protein-coupled GABA receptor activity, G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential, G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential, G protein-coupled receptor activity, extracellular matrix protein binding, protein binding, protein heterodimerization activity; CC: G protein-coupled GABA receptor complex, G protein-coupled receptor dimeric complex, G protein-coupled receptor heterodimeric complex, GABA receptor complex, GABA-ergic synapse, Schaffer collateral - CA1 synapse, axolemma, cell projection, cytoplasm, dendrite, dendritic shaft, dendritic spine, endoplasmic reticulum membrane, extracellular space, glutamatergic synapse, membrane, mitochondrial membrane, neuronal cell body, plasma membrane, postsynaptic membrane, presynapse, presynaptic membrane, synapse, synaptic membrane, synaptic vesicle
Pathways: Activation of G protein gated Potassium channels, Activation of GABAB receptors, Class C/3 (Metabotropic glutamate/pheromone receptors), Estrogen signaling pathway - Mus musculus (mouse), G alpha (i) signalling events, G protein gated Potassium channels, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, GPCR ligand binding, GnRH secretion - Mus musculus (mouse), Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Inwardly rectifying K+ channels, Morphine addiction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Potassium Channels, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse), Transmission across Chemical Synapses, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q9WV18
Entrez ID: 54393
|
Does Knockout of Klhl33 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Klhl33
|
cell cycle progression
|
breast epithelium
|
Gene: Klhl33 (kelch-like 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: G3UW92, A0A2I3BRZ3, B7ZMY3
Entrez ID: 546611
|
Does Knockout of Pfn4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Pfn4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pfn4 (profilin family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acrosome assembly, cell differentiation, flagellated sperm motility, manchette assembly, sperm flagellum assembly, spermatogenesis; MF: actin binding, actin monomer binding, lipid binding; CC: cell cortex, cytoplasm
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse)
UniProt: Q9D6I3
Entrez ID: 382562
|
Does Knockout of Saa1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Saa1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Saa1 (serum amyloid A 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acute-phase response, cholesterol metabolic process, response to bacterium; MF: G protein-coupled receptor binding, heparin binding, protein binding; CC: cytoplasmic microtubule, extracellular region, extracellular space, high-density lipoprotein particle
Pathways:
UniProt: P05366
Entrez ID: 20208
|
Does Knockout of Fkbp5 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Fkbp5
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Fkbp5 (FK506 binding protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol 3-kinase/protein kinase B signal transduction, protein folding, response to alcohol, response to bacterium, response to cocaine; MF: heat shock protein binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity, protein binding, protein-macromolecule adaptor activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, ESR-mediated signaling, Estrogen signaling pathway - Mus musculus (mouse), HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Immune System, Interferon Signaling, Modulation of host responses by IFN-stimulated genes, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q64378
Entrez ID: 14229
|
Does Knockout of Kctd18 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Kctd18
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kctd18 (potassium channel tetramerisation domain containing 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein homooligomerization
Pathways:
UniProt: E9Q945, E0CZ26, Q6DI85, E9PYP3, E0CXJ5
Entrez ID: 51960
|
Does Knockout of Dab1 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Dab1
|
response to bacteria
|
renal medulla cell line
|
Gene: Dab1 (disabled 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi localization, adult walking behavior, cell differentiation, cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration, central nervous system development, central nervous system neuron differentiation, cerebellum structural organization, cerebral cortex cell migration, cerebral cortex radially oriented cell migration, dendrite development, hippocampus development, intracellular signal transduction, lateral motor column neuron migration, motor neuron migration, negative regulation of astrocyte differentiation, negative regulation of axonogenesis, negative regulation of cell adhesion, negative regulation of receptor signaling pathway via JAK-STAT, nervous system development, neuron migration, positive regulation of neuron differentiation, radial glia guided migration of Purkinje cell, radial glia-guided pyramidal neuron migration, reelin-mediated signaling pathway, regulation of synapse maturation, small GTPase-mediated signal transduction, ventral spinal cord development; MF: SH2 domain binding, phosphatidylinositol 3-kinase binding, phospholipid binding, protein binding, signaling adaptor activity; CC: apical part of cell, brush border, cytoplasm, glutamatergic synapse, intracellular membrane-bounded organelle, neuronal cell body, perinuclear region of cytoplasm, synapse
Pathways: Axon guidance, Developmental Biology, Nervous system development, Reelin signalling pathway, Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: P97318
Entrez ID: 13131
|
Does Knockout of Ugt1a6b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Ugt1a6b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ugt1a6b (UDP glucuronosyltransferase 1 family, polypeptide A6B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 4-chlorobiphenyl metabolic process, cellular response to glucocorticoid stimulus, xenobiotic metabolic process; MF: UDP-glycosyltransferase activity, enzyme binding, glucuronosyltransferase activity, glycosyltransferase activity, protein heterodimerization activity, protein homodimerization activity, protein-containing complex binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, protein-containing complex
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), Bile secretion - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pentose and glucuronate interconversions - Mus musculus (mouse), Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse)
UniProt: K9J7B2
Entrez ID: 394435
|
Does Knockout of Acadvl in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Acadvl
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Acadvl (acyl-Coenzyme A dehydrogenase, very long chain)
Type: protein-coding
Summary: This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: epithelial cell differentiation, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid catabolic process, fatty acid metabolic process, lipid metabolic process, negative regulation of fatty acid biosynthetic process, negative regulation of fatty acid oxidation, regulation of cholesterol metabolic process, response to cold, temperature homeostasis; MF: acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, flavin adenine dinucleotide binding, identical protein binding, long-chain fatty acyl-CoA dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, very-long-chain fatty acyl-CoA dehydrogenase activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrial nucleoid, mitochondrion, nucleolus, nucleoplasm
Pathways: Alcoholic liver disease - Mus musculus (mouse), Beta oxidation of palmitoyl-CoA to myristoyl-CoA, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, fatty acid β-oxidation I, mitochondrial fatty acid beta-oxidation of saturated fatty acids
UniProt: P50544
Entrez ID: 11370
|
Does Knockout of Celf1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Celf1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Celf1 (CUGBP, Elav-like family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cerebral cortex development, cerebral cortex neuron differentiation, mRNA destabilization, mRNA processing, mRNA splice site recognition, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation, negative regulation of gene expression, negative regulation of translation, positive regulation of gene expression, positive regulation of multicellular organism growth, post-transcriptional gene silencing, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, regulation of cell cycle, regulation of inflammatory response, spermatid development; MF: BRE binding, RNA binding, lncRNA binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, mRNA binding, nucleic acid binding, pre-mRNA binding, translation initiation factor binding; CC: cytoplasm, cytoplasmic stress granule, male germ cell nucleus, nucleoplasm, nucleus, perinucleolar compartment, ribonucleoprotein complex
Pathways:
UniProt: P28659
Entrez ID: 13046
|
Does Knockout of Tpsb2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Tpsb2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tpsb2 (tryptase beta 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inflammatory response, proteolysis; MF: heparin binding, hydrolase activity, identical protein binding, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region, extracellular space
Pathways: Influenza A - Mus musculus (mouse)
UniProt: A0AAA9WUV3, E9QJW9, A0AAA9WW04, A0AAA9WUU9, A0AAA9WUV2, A0A3Q4L2Q9, A0AAA9WWF7
Entrez ID: 17229
|
Does Knockout of Plekha6 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Plekha6
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Plekha6 (pleckstrin homology domain containing, family A member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism, Synthesis of PIPs at the plasma membrane
UniProt: Q7TQG1
Entrez ID: 240753
|
Does Knockout of Kif21a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Kif21a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kif21a (kinesin family member 21A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal transport, cortical microtubule organization, microtubule-based movement, regulation of axon guidance, regulation of microtubule depolymerization, regulation of microtubule polymerization; MF: ATP binding, ATP hydrolysis activity, ankyrin repeat binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity; CC: axon, axon cytoplasm, axonal growth cone, cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, dendrite, growth cone, kinesin complex, microtubule, presynapse
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9QXL2
Entrez ID: 16564
|
Does Knockout of Lyz1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Lyz1
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Lyz1 (lysozyme 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, killing of cells of another organism; MF: catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, identical protein binding, lysozyme activity; CC: Golgi cis cisterna, Golgi stack, endoplasmic reticulum lumen, extracellular region, extracellular space, microvillus, rough endoplasmic reticulum lumen, secretory granule, trans-Golgi network transport vesicle
Pathways: Salivary secretion - Mus musculus (mouse)
UniProt: P17897
Entrez ID: 17110
|
Does Knockout of Rps6kl1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Rps6kl1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rps6kl1 (ribosomal protein S6 kinase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: ribonucleoprotein complex, ribosome
Pathways:
UniProt: Q8R2S1
Entrez ID: 238323
|
Does Knockout of Gm20867 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Gm20867
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gm20867 (predicted gene, 20867)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5FWD4
Entrez ID: 100041256
|
Does Knockout of Scgb2b12 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Scgb2b12
|
cell cycle progression
|
breast epithelium
|
Gene: Scgb2b12 (secretoglobin, family 2B, member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region, extracellular space
Pathways:
UniProt: S4R2L0
Entrez ID: 668379
|
Does Knockout of Rab3a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Rab3a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rab3a (RAB3A, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acrosomal vesicle exocytosis, axonogenesis, calcium-ion regulated exocytosis, establishment of localization in cell, evoked neurotransmitter secretion, exocytosis, insulin secretion, lung development, lysosome localization, maintenance of presynaptic active zone structure, mitochondrion organization, neuromuscular synaptic transmission, plasma membrane repair, positive regulation of regulated secretory pathway, post-embryonic development, protein transport, regulated exocytosis, regulation of dopamine secretion, regulation of exocytosis, regulation of long-term synaptic potentiation, regulation of plasma membrane repair, regulation of presynaptic dense core granule exocytosis, regulation of short-term neuronal synaptic plasticity, regulation of synaptic vesicle exocytosis, regulation of synaptic vesicle fusion to presynaptic active zone membrane, regulation of synaptic vesicle priming, respiratory system process, response to electrical stimulus, sensory perception of touch, synaptic vesicle clustering, synaptic vesicle exocytosis, synaptic vesicle maturation, synaptic vesicle recycling, synaptic vesicle transport; MF: ATPase activator activity, ATPase binding, G protein activity, GDP-dissociation inhibitor binding, GTP binding, GTP-dependent protein binding, GTPase activity, hydrolase activity, metal ion binding, myosin V binding, nucleotide binding, protein binding, protein-macromolecule adaptor activity; CC: acrosomal vesicle, axon, cell projection, clathrin-sculpted glutamate transport vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endosome, lysosome, membrane, perinuclear region of cytoplasm, plasma membrane, postsynapse, presynapse, presynaptic active zone, protein-containing complex, secretory granule, synapse, synaptic vesicle, synaptic vesicle membrane, terminal bouton, transport vesicle
Pathways: Acetylcholine Neurotransmitter Release Cycle, Dopamine Neurotransmitter Release Cycle, GABA synthesis, release, reuptake and degradation, Glutamate Neurotransmitter Release Cycle, Immune System, Innate Immune System, Insulin secretion - Mus musculus (mouse), Membrane Trafficking, Metabolism of proteins, Neuronal System, Neurotransmitter release cycle, Neutrophil degranulation, Norepinephrine Neurotransmitter Release Cycle, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Serotonin Neurotransmitter Release Cycle, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Vesicle-mediated transport
UniProt: P63011
Entrez ID: 19339
|
Does Knockout of Nampt in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Nampt
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Nampt (nicotinamide phosphoribosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway, NADP+ biosynthetic process, circadian regulation of gene expression, circadian rhythm, inflammatory response, microglial cell activation, negative regulation of autophagy, negative regulation of cellular senescence, nicotinamide metabolic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of gene expression, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, pyridine nucleotide biosynthetic process, regulation of lung blood pressure, rhythmic process, signal transduction; MF: cytokine activity, glycosyltransferase activity, heterocyclic compound binding, identical protein binding, nicotinamide phosphoribosyltransferase activity, nucleotide binding, transferase activity; CC: cell junction, cytoplasm, cytosol, extracellular region, extracellular space, mitochondrial matrix, nuclear speck, nucleus
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NAD biosynthesis III, NOD-like receptor signaling pathway - Mus musculus (mouse), Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nicotinate metabolism
UniProt: Q99KQ4
Entrez ID: 59027
|
Does Knockout of Akr1b8 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Akr1b8
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Akr1b8 (aldo-keto reductase family 1, member B8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, polyol metabolic process, retinal metabolic process, retinol metabolic process; MF: NADP+ binding, NADPH binding, alcohol dehydrogenase (NADP+) activity, aldose reductase (NADPH) activity, all-trans-retinol dehydrogenase (NADP+) activity, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, geranylgeranyl reductase activity, indanol dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, retinal binding, retinal dehydrogenase (NAD+) activity; CC: cytoplasm, cytosol, extracellular region, lysosome, mitochondrion
Pathways: Estrogen biosynthesis, Folate biosynthesis - Mus musculus (mouse), Fructose and mannose metabolism - Mus musculus (mouse), Galactose metabolism - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), L-arabinose degradation II, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Pentose and glucuronate interconversions - Mus musculus (mouse)
UniProt: P45377
Entrez ID: 14187
|
Does Knockout of Lhx8 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Lhx8
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Lhx8 (LIM homeobox protein 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: female gonad development, forebrain neuron development, forebrain neuron differentiation, learning or memory, neuron differentiation, odontogenesis of dentin-containing tooth, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding; CC: female germ cell nucleus, nucleus
Pathways:
UniProt: O35652
Entrez ID: 16875
|
Does Knockout of Slc17a3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Slc17a3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc17a3 (solute carrier family 17 (sodium phosphate), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic anion transmembrane transport, monoatomic ion transport, organic anion transport, sodium ion transport, transmembrane transport, urate metabolic process, urate transport, xenobiotic detoxification by transmembrane export across the plasma membrane; MF: efflux transmembrane transporter activity, organic anion transmembrane transporter activity, symporter activity, toxin transmembrane transporter activity, transmembrane transporter activity, urate transmembrane transporter activity, voltage-gated monoatomic anion channel activity, xenobiotic transmembrane transporter activity; CC: apical plasma membrane, cytoplasm, endoplasmic reticulum membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q5SZ92, G3UWD9, Q5SZ93
Entrez ID: 105355
|
Does Knockout of Dmrtc1b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Dmrtc1b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dmrtc1b (DMRT-like family C1b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q2PMX7, A2AI93, Q2PMX6
Entrez ID: 632708
|
Does Knockout of Jmjd8 in cardiac muscle cell line causally result in protein/peptide accumulation?
| 0
| 1,662
|
Knockout
|
Jmjd8
|
protein/peptide accumulation
|
cardiac muscle cell line
|
Gene: Jmjd8 (jumonji domain containing 8)
Type: protein-coding
Summary: Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular respiration and sprouting angiogenesis. Is active in cytoplasm. Is expressed in brain; gonad; lung; metanephros; and submandibular gland. Orthologous to human JMJD8 (jumonji domain containing 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular respiration, positive regulation of canonical NF-kappaB signal transduction, positive regulation of sprouting angiogenesis, regulation of glycolytic process, regulation of pyruvate kinase activity, sprouting angiogenesis; MF: cis-regulatory region sequence-specific DNA binding, molecular_function, protein binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum lumen, nucleus
Pathways:
UniProt: Q3TA59
Entrez ID: 72106
|
Does Knockout of Atp6v0a1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Atp6v0a1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Atp6v0a1 (ATPase, H+ transporting, lysosomal V0 subunit A1)
Type: protein-coding
Summary: Predicted to enable ATPase binding activity. Involved in synaptic vesicle lumen acidification. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 104. Orthologous to human ATP6V0A1 (ATPase H+ transporting V0 subunit a1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification, vacuolar acidification; MF: ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: Golgi apparatus, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, melanosome, membrane, nuclear speck, perinuclear region of cytoplasm, plasma membrane, proton-transporting V-type ATPase, V0 domain, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Mus musculus (mouse), Neutrophil degranulation, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Mus musculus (mouse)
UniProt: Q9Z1G4
Entrez ID: 11975
|
Does Knockout of Btbd35f11 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Btbd35f11
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Btbd35f11 (BTB domain containing 35, family member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, germ cell development
Pathways:
UniProt: A2BFZ7
Entrez ID: 668958
|
Does Knockout of Atp13a5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Atp13a5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atp13a5 (ATPase type 13A5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular calcium ion homeostasis, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, polyamine transmembrane transport; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled monoatomic cation transmembrane transporter activity, P-type ion transporter activity, P-type transmembrane transporter activity, metal ion binding, nucleotide binding, polyamine transmembrane transporter activity; CC: late endosome membrane, membrane
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: Q3TYU2
Entrez ID: 268878
|
Does Knockout of Kidins220 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Kidins220
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Kidins220 (kinase D-interacting substrate 220)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to nerve growth factor stimulus, dendrite morphogenesis, in utero embryonic development, nerve growth factor signaling pathway, nervous system development, positive regulation of neuron projection development; MF: PDZ domain binding, protein kinase binding, protein kinase regulator activity; CC: cytosol, endosome, glutamatergic synapse, late endosome, membrane, postsynapse, protein-containing complex
Pathways: ARMS-mediated activation, Neurotrophin signaling pathway - Mus musculus (mouse), Prolonged ERK activation events, RHO GTPase cycle, RND1 GTPase cycle, RND2 GTPase cycle, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signalling to ERKs
UniProt: E9Q9B7, A0A1Y7VME9, A0A1Y7VK25, A0A1Y7VNF8, A0A1Y7VMH7
Entrez ID: 77480
|
Does Knockout of Ly6g5b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Ly6g5b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ly6g5b (lymphocyte antigen 6 family member G5B)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Colocalizes with external side of plasma membrane. Is expressed in several structures, including brain; liver; lung; metanephros; and spleen. Orthologous to human LY6G5B (lymphocyte antigen 6 family member G5B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: identical protein binding; CC: external side of plasma membrane, extracellular region, protein-containing complex
Pathways:
UniProt: Q8K1T4
Entrez ID: 266614
|
Does Knockout of Mrgpra3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Mrgpra3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mrgpra3 (MAS-related GPR, member A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, acute-phase response, cell surface receptor signaling pathway, chemosensory behavior, response to chloroquine, signal transduction; MF: G protein-coupled receptor activity, neuropeptide binding, transmembrane signaling receptor activity; CC: axon, membrane, neuronal cell body membrane, plasma membrane
Pathways:
UniProt: Q91WW3
Entrez ID: 233222
|
Does Knockout of 4930423O20Rik in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
4930423O20Rik
|
phagocytosis
|
macrophage
|
Gene: 4930423O20Rik (RIKEN cDNA 4930423O20 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 73946
|
Does Knockout of Cd5 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Cd5
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Cd5 (CD5 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell costimulation, apoptotic signaling pathway; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Hematopoietic cell lineage - Mus musculus (mouse)
UniProt: P13379
Entrez ID: 12507
|
Does Knockout of Swsap1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Swsap1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Swsap1 (SWIM type zinc finger 7 associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, double-strand break repair via homologous recombination, protein stabilization; MF: ATP hydrolysis activity, DNA binding, single-stranded DNA binding; CC: Shu complex, nucleus
Pathways:
UniProt: Q8VCI7
Entrez ID: 66962
|
Does Knockout of Snrpb2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Snrpb2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Snrpb2 (U2 small nuclear ribonucleoprotein B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, U1 snRNA binding, nucleic acid binding, protein binding, snRNP binding; CC: U1 snRNP, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, cytoplasmic ribonucleoprotein granule, fibrillar center, nuclear speck, nucleus, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, spliceosomal snRNP complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9CQI7
Entrez ID: 20639
|
Does Knockout of Polr2j in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,268
|
Knockout
|
Polr2j
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Polr2j (polymerase (RNA) II (DNA directed) polypeptide J)
Type: protein-coding
Summary: Predicted to enable LRR domain binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II, core complex. Is expressed in several structures, including alimentary system; branchial arch; integumental system; limb; and nervous system. Orthologous to several human genes including POLR2J (RNA polymerase II subunit J). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription, transcription by RNA polymerase II; MF: DNA binding, DNA-directed RNA polymerase activity, LRR domain binding, protein binding, protein dimerization activity; CC: DNA-directed RNA polymerase complex, RNA polymerase II, core complex, nucleoplasm, nucleus
Pathways: Huntington disease - Mus musculus (mouse), RNA polymerase - Mus musculus (mouse)
UniProt: Q3TYI2, Q6PI63, D3YZ19, D3YZ20
Entrez ID: 20022
|
Does Knockout of Chst2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Chst2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Chst2 (carbohydrate sulfotransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-acetylglucosamine metabolic process, carbohydrate metabolic process, inflammatory response, positive regulation of leukocyte tethering or rolling, sulfur compound metabolic process; MF: N-acetylglucosamine 6-O-sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, cytosol, membrane, nucleoplasm, trans-Golgi network
Pathways: Glycosaminoglycan biosynthesis - keratan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q80WV3
Entrez ID: 54371
|
Does Knockout of Tsku in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Tsku
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tsku (tsukushi, small leucine rich proteoglycan)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, anterior commissure morphogenesis, camera-type eye development, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, ciliary body morphogenesis, corpus callosum morphogenesis, energy homeostasis, hippocampus development, inner ear receptor cell stereocilium organization, lateral ventricle development, negative regulation of Wnt signaling pathway, negative regulation of myofibroblast differentiation, negative regulation of neuron projection development, negative regulation of transforming growth factor beta1 production, nervous system development, positive regulation of hair cycle, regulation of gene expression, wound healing; MF: cytokine binding, protein binding, signaling receptor activity, transforming growth factor beta binding; CC: extracellular region, extracellular space, plasma membrane
Pathways:
UniProt: Q8CBR6
Entrez ID: 244152
|
Does Knockout of Cep350 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Cep350
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cep350 (centrosomal protein 350)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule anchoring, non-motile cilium assembly, protein localization to centrosome; MF: microtubule binding, protein binding; CC: cell projection, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, spindle
Pathways:
UniProt: E9Q309
Entrez ID: 74081
|
Does Knockout of Gm5071 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Gm5071
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Gm5071 (predicted gene 5071)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 278087
|
Does Knockout of Hepacam2 in Non-Small Cell Lung Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,189
|
Knockout
|
Hepacam2
|
tumorigenicity
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: Hepacam2 (HEPACAM family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle; CC: Golgi apparatus, Golgi membrane, centrosome, cytoplasm, cytoskeleton, membrane, midbody, mitotic spindle, nucleoplasm, spindle
Pathways:
UniProt: Q4VAH7
Entrez ID: 101202
|
Does Knockout of Zfp712 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Zfp712
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Zfp712 (zinc finger protein 712)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of macromolecule biosynthetic process, regulation of DNA-templated transcription, regulation of anatomical structure morphogenesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: E9PXJ4
Entrez ID: 78251
|
Does Knockout of Cyp2e1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Cyp2e1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 4-nitrophenol metabolic process, epoxygenase P450 pathway, fatty acid metabolic process, lipid hydroxylation, lipid metabolic process, long-chain fatty acid metabolic process, monoterpenoid metabolic process, response to bacterium, steroid metabolic process, triglyceride metabolic process, xenobiotic metabolic process; MF: 4-nitrophenol 2-monooxygenase activity, Hsp70 protein binding, Hsp90 protein binding, arachidonate epoxygenase activity, enzyme binding, heme binding, iron ion binding, long-chain fatty acid omega-1 hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Alcoholic liver disease - Mus musculus (mouse), Arachidonic acid metabolism - Mus musculus (mouse), Aspirin ADME, Biological oxidations, Biosynthesis of DHA-derived SPMs, Biosynthesis of maresin-like SPMs, Biosynthesis of maresins, Biosynthesis of specialized proresolving mediators (SPMs), CYP2E1 reactions, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Cytochrome P450 - arranged by substrate type, Drug ADME, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Paracetamol ADME, Phase I - Functionalization of compounds, Steroid hormone biosynthesis - Mus musculus (mouse), Xenobiotics, bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q05421
Entrez ID: 13106
|
Does Knockout of Artn in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Artn
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Artn (artemin)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Mice lacking a functional copy of this gene exhibit ptosis and impaired development of the sympathetic nervous system. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: Peyer's patch morphogenesis, axon guidance, cell surface receptor signaling pathway, glial cell-derived neurotrophic factor receptor signaling pathway, induction of positive chemotaxis, lymphocyte migration into lymphoid organs, nervous system development, peripheral nervous system development; MF: glial cell-derived neurotrophic factor receptor binding, growth factor activity, protein binding, receptor tyrosine kinase binding, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Axon guidance, Developmental Biology, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Nervous system development, RAF/MAP kinase cascade, RET signaling, Signal Transduction
UniProt: Q9Z0L2
Entrez ID: 11876
|
Does Knockout of Nme7 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Nme7
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Nme7 (NME/NM23 family member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CTP biosynthetic process, DNA catabolic process, GTP biosynthetic process, UTP biosynthetic process, brain development, cellular response to leukemia inhibitory factor, cilium assembly, determination of left/right symmetry, epithelial cilium movement involved in extracellular fluid movement, flagellated sperm motility, intraciliary transport, left/right pattern formation, receptor clustering, regulation of microtubule nucleation, smoothened signaling pathway; MF: 3'-5'-DNA exonuclease activity, ATP binding, hydrolase activity, kinase activity, metal ion binding, nucleoside diphosphate kinase activity, protein kinase activity, transferase activity; CC: axonemal A tubule inner sheath, axonemal microtubule, cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, extracellular region, gamma-tubulin ring complex, motile cilium, nucleoplasm, nucleus, plasma membrane, sperm flagellum, spindle
Pathways: Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Drug metabolism - other enzymes - Mus musculus (mouse), G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, adenosine nucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis I, pyrimidine ribonucleotides <i>de novo</i> biosynthesis, pyrimidine ribonucleotides interconversion
UniProt: Q9QXL8
Entrez ID: 171567
|
Does Knockout of Gipr in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Gipr
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gipr (gastric inhibitory polypeptide receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, desensitization of G protein-coupled receptor signaling pathway, endocrine pancreas development, gastric inhibitory peptide signaling pathway, neuropeptide signaling pathway, positive regulation of cytosolic calcium ion concentration, positive regulation of insulin secretion, response to axon injury, response to calcium ion, response to fatty acid, response to glucose, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, gastric inhibitory peptide receptor activity, glucagon family peptide binding, peptide hormone binding, signaling receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Glucagon-type ligand receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q0P543
Entrez ID: 381853
|
Does Knockout of Vmn1r224 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Vmn1r224
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn1r224 (vomeronasal 1 receptor 224)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: A0A3B2W7L7, E9PWK2, A0A3B2WBL6
Entrez ID: 665525
|
Does Knockout of Rad23b in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,543
|
Knockout
|
Rad23b
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rad23b (RAD23 homolog B, nucleotide excision repair protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, UV-damage excision repair, cellular response to interleukin-7, embryonic organ development, nucleotide-excision repair, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of proteasomal ubiquitin-dependent protein catabolic process, spermatogenesis; MF: DNA damage sensor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, damaged DNA binding, polyubiquitin modification-dependent protein binding, proteasome binding, protein binding, transcription cis-regulatory region binding, ubiquitin binding; CC: XPC complex, cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex
Pathways: Asparagine N-linked glycosylation, DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), Josephin domain DUBs, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: P54728
Entrez ID: 19359
|
Does Knockout of Spaca4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Spaca4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Spaca4 (sperm acrosome associated 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, cell adhesion, fertilization, single fertilization, sperm-egg recognition; CC: acrosomal vesicle, cytoplasmic vesicle, inner acrosomal membrane, membrane, outer acrosomal membrane, plasma membrane, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q80ZQ0
Entrez ID: 69363
|
Does Knockout of Ankrd12 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Ankrd12
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ankrd12 (ankyrin repeat domain 12)
Type: protein-coding
Summary: Predicted to be located in cytosol. Predicted to be active in nucleoplasm. Orthologous to human ANKRD12 (ankyrin repeat domain 12). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cytosol, nucleoplasm
Pathways:
UniProt: Q05CM6, G5E893, Q80TP9, Q3U569, A0A3B2W7I2, A0A3B2W3X3, A0A3B2W470, A0A3B2WAN9
Entrez ID: 106585
|
Does Knockout of Dera in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Dera
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Dera (deoxyribose-phosphate aldolase)
Type: protein-coding
Summary: Predicted to enable deoxyribose-phosphate aldolase activity. Predicted to be involved in carbohydrate catabolic process; deoxyribonucleoside catabolic process; and deoxyribonucleotide catabolic process. Predicted to be located in nucleoplasm. Orthologous to human DERA (deoxyribose-phosphate aldolase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: carbohydrate catabolic process, deoxyribonucleoside catabolic process, deoxyribonucleotide catabolic process, deoxyribose phosphate catabolic process; MF: deoxyribose-phosphate aldolase activity, lyase activity; CC: cytoplasm, nucleoplasm, nucleus
Pathways: (deoxy)ribose phosphate degradation, Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), pyrimidine deoxyribonucleosides degradation
UniProt: Q91YP3
Entrez ID: 232449
|
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