prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ppp2cb in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Ppp2cb
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ppp2cb (protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic mitochondrial changes, mitotic cell cycle, negative regulation of Ras protein signal transduction, negative regulation of canonical NF-kappaB signal transduction, negative regulation of gene expression, negative regulation of tumor necrosis factor-mediated signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of gene expression, regulation of microtubule polymerization, response to antibiotic, response to endoplasmic reticulum stress, response to hydrogen peroxide, response to lead ion; MF: hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, transmembrane transporter binding; CC: FAR/SIN/STRIPAK complex, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, nucleus, protein phosphatase type 2A complex, spindle pole
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Antiviral mechanism by IFN-stimulated genes, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Beta-catenin phosphorylation cascade, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chagas disease - Mus musculus (mouse), Co-inhibition by CTLA4, Co-stimulation by CD28, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin D associated events in G1, Cytokine Signaling in Immune system, DARPP-32 events, Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Dopaminergic synapse - Mus musculus (mouse), E2F mediated regulation of DNA replication, EML4 and NUDC in mitotic spindle formation, ERK/MAPK targets, ERKs are inactivated, G alpha (i) signalling events, G1 Phase, G1/S Transition, G2/M Transition, GPCR downstream signalling, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, Hepatitis C - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Innate Immune System, Interferon Signaling, Interleukin-17 signaling, Intracellular signaling by second messengers, Long-term depression - Mus musculus (mouse), M Phase, MAP kinase activation, MAPK family signaling cascades, MAPK targets/ Nuclear events mediated by MAP kinases, MAPK1/MAPK3 signaling, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of MAPK pathway, Negative regulation of the PI3K/AKT network, Nuclear Events (kinase and transcription factor activation), Oocyte meiosis - Mus musculus (mouse), Opioid Signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PKR-mediated signaling, Platelet homeostasis, Platelet sensitization by LDL, RAF activation, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Sphingolipid signaling pathway - Mus musculus (mouse), Spry regulation of FGF signaling, TCF dependent signaling in response to WNT, TGF-beta signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Tight junction - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcriptional Regulation by TP53, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P62715
Entrez ID: 19053
|
Does Knockout of Smpd3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Smpd3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Smpd3 (sphingomyelin phosphodiesterase 3, neutral)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, DNA biosynthetic process, G1 to G0 transition, artery smooth muscle contraction, bone development, bone growth, bone mineralization, cartilage development, cellular response to hydrogen peroxide, cellular response to magnesium ion, cellular response to oxidised low-density lipoprotein particle stimulus, cellular response to peptide, cellular response to reactive oxygen species, cellular response to redox state, cellular response to tumor necrosis factor, ceramide metabolic process, chondrocyte development, chondrocyte development involved in endochondral bone morphogenesis, collagen metabolic process, dentinogenesis, dopamine uptake, endochondral ossification, extracellular matrix assembly, hematopoietic progenitor cell differentiation, lipid metabolic process, lung alveolus development, lung development, mitotic nuclear division, multicellular organism growth, negative regulation of cytosolic calcium ion concentration, negative regulation of hyaluronan biosynthetic process, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, ossification, peptide hormone secretion, platelet-derived growth factor receptor signaling pathway, polysaccharide transport, positive regulation of ceramide biosynthetic process, positive regulation of exosomal secretion, positive regulation of mitotic nuclear division, positive regulation of nitric oxide biosynthetic process, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of smooth muscle cell proliferation, regulation of cartilage development, regulation of hyaluronan biosynthetic process, regulation of leukocyte migration, respiratory system development, signal transduction, skeletal system development, sphingolipid mediated signaling pathway, sphingolipid metabolic process, sphingomyelin catabolic process, sphingomyelin metabolic process; MF: catalytic activity, hydrolase activity, identical protein binding, metal ion binding, neutral sphingomyelin phosphodiesterase activity, phosphatidic acid binding, phosphatidylserine binding, phosphoric diester hydrolase activity, protein binding, sphingomyelin phosphodiesterase activity; CC: Golgi apparatus, Golgi cis cisterna, Golgi membrane, cytoplasm, extracellular region, membrane, plasma membrane
Pathways: Death Receptor Signaling, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Signal Transduction, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), TNF signaling, TNFR1-mediated ceramide production, sphingomyelin metabolism
UniProt: Q9JJY3
Entrez ID: 58994
|
Does Knockout of Cfap45 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Cfap45
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cfap45 (cilia and flagella associated protein 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebrospinal fluid circulation, epithelial cilium movement involved in determination of left/right asymmetry, establishment of left/right asymmetry, flagellated sperm motility, regulation of cilium beat frequency involved in ciliary motility; MF: AMP binding, protein binding; CC: 9+0 motile cilium, 9+2 motile cilium, axonemal B tubule inner sheath, axonemal microtubule, axoneme, cell projection, cilium, cytoplasm, cytoskeleton, extracellular region, motile cilium, polymeric cytoskeletal fiber, sperm flagellum
Pathways:
UniProt: Q9D9U9
Entrez ID: 71870
|
Does Knockout of C1qa in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
C1qa
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: C1qa (complement component 1, q subcomponent, alpha polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: astrocyte activation, complement activation, classical pathway, complement-mediated synapse pruning, immune system process, innate immune response, microglial cell activation, neuron remodeling, synapse organization, synapse pruning, vertebrate eye-specific patterning; MF: IgG binding, IgM binding, metal ion binding, phosphatidylserine binding, protein binding; CC: cell surface, collagen trimer, complement component C1 complex, complement component C1q complex, extracellular region, extracellular space, extrinsic component of postsynaptic membrane, extrinsic component of presynaptic membrane, glutamatergic synapse, postsynapse, symbiont cell surface, synapse
Pathways: Alcoholic liver disease - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Classical antibody-mediated complement activation, Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Coronavirus disease - COVID-19 - Mus musculus (mouse), Creation of C4 and C2 activators, Immune System, Initial triggering of complement, Innate Immune System, Pertussis - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Regulation of Complement cascade, Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse)
UniProt: P98086
Entrez ID: 12259
|
Does Knockout of Tpt1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Tpt1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tpt1 (tumor protein, translationally-controlled 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of ectoderm development, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, response to virus, spermatogenesis, stem cell population maintenance; MF: DNA-binding transcription factor binding, calcium ion binding, protein binding; CC: cytoplasm, cytoplasmic microtubule, cytosol, extracellular space, multivesicular body, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: P63028
Entrez ID: 22070
|
Does Knockout of Agrn in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Agrn
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Agrn (agrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chemical synaptic transmission, circadian rhythm, enzyme-linked receptor protein signaling pathway, filopodium assembly, membrane organization, negative regulation of sodium ion export across plasma membrane, neuromuscular junction development, neurotransmitter receptor localization to postsynaptic specialization membrane, plasma membrane organization, positive regulation of Rac protein signal transduction, positive regulation of cellular component biogenesis, positive regulation of cellular component organization, positive regulation of filopodium assembly, positive regulation of motor neuron apoptotic process, positive regulation of protein binding, positive regulation of protein geranylgeranylation, positive regulation of protein phosphorylation, positive regulation of skeletal muscle acetylcholine-gated channel clustering, positive regulation of synaptic assembly at neuromuscular junction, positive regulation of transcription by RNA polymerase II, protein transport, receptor clustering, regulation of GTPase activity, regulation of axon guidance, regulation of cardiac muscle cell membrane potential, regulation of cardiac muscle contraction, regulation of microtubule cytoskeleton organization, regulation of synapse organization, regulation of synaptic activity, skeletal muscle acetylcholine-gated channel clustering, synapse assembly; MF: ATPase inhibitor activity, BMP binding, acetylcholine receptor regulator activity, calcium ion binding, chondroitin sulfate binding, dystroglycan binding, extracellular matrix structural constituent, heparan sulfate proteoglycan binding, metal ion binding, protein binding, receptor ligand activity, sialic acid binding, transforming growth factor beta binding, transmembrane transporter binding, transporter inhibitor activity; CC: Golgi lumen, axonal growth cone, basement membrane, cell surface, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, membrane, plasma membrane, sarcolemma, synapse
Pathways: ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, HS-GAG biosynthesis, HS-GAG degradation, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Non-integrin membrane-ECM interactions, Retinoid metabolism and transport, Sensory Perception, Visual phototransduction
UniProt: A2ASQ1
Entrez ID: 11603
|
Does Knockout of Chaf1b in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Chaf1b
|
cell proliferation
|
Regulatory T cell
|
Gene: Chaf1b (chromatin assembly factor 1, subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin assembly, chromatin organization, nucleosome assembly; CC: CAF-1 complex, chromatin, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q9D0N7
Entrez ID: 110749
|
Does Knockout of Polr3e in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Polr3e
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Polr3e (polymerase (RNA) III (DNA directed) polypeptide E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, defense response to virus, immune system process, innate immune response; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q9CZT4
Entrez ID: 26939
|
Does Knockout of Prrx2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Prrx2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Prrx2 (paired related homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: artery morphogenesis, cartilage development, embryonic cranial skeleton morphogenesis, embryonic limb morphogenesis, embryonic skeletal system morphogenesis, inner ear morphogenesis, mesenchymal cell proliferation, middle ear morphogenesis, positive regulation of mesenchymal cell proliferation, positive regulation of smoothened signaling pathway, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, stem cell proliferation, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, HMG box domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q06348
Entrez ID: 20204
|
Does Knockout of Apip in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Apip
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Apip (APAF1 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-methionine salvage from methylthioadenosine, amino acid biosynthetic process, apoptotic process, methionine biosynthetic process, negative regulation of apoptotic process, protein homotetramerization, pyroptotic inflammatory response, regulation of ERK1 and ERK2 cascade; MF: identical protein binding, lyase activity, metal ion binding, methylthioribulose 1-phosphate dehydratase activity, zinc ion binding; CC: cytoplasm
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse)
UniProt: Q9WVQ5
Entrez ID: 56369
|
Does Knockout of Meioc in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,550
|
Knockout
|
Meioc
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Meioc (meiosis specific with coiled-coil domain)
Type: protein-coding
Summary: Involved in several processes, including germ cell development; germline cell cycle switching, mitotic to meiotic cell cycle; and meiosis I. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; liver; lung; reproductive system; and spleen. Orthologous to human MEIOC (meiosis specific with coiled-coil domain). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromosome organization involved in meiotic cell cycle, double-strand break repair, female meiosis I, germline cell cycle switching, mitotic to meiotic cell cycle, mRNA stabilization, male meiosis I, meiotic cell cycle, metaphase chromosome alignment, oocyte development, spermatid development, spermatogenesis, synaptonemal complex assembly; CC: cytoplasm, nucleus
Pathways:
UniProt: A2AG06
Entrez ID: 268491
|
Does Knockout of Snu13 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Snu13
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Snu13 (SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5))
Type: protein-coding
Summary: Enables box C/D sno(s)RNA binding activity. Involved in box C/D snoRNP assembly. Acts upstream of or within single fertilization. Part of box C/D methylation guide snoRNP complex. Is expressed in head. Orthologous to human SNU13 (small nuclear ribonucleoprotein 13). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, box C/D snoRNP assembly, mRNA processing, mRNA splicing, via spliceosome, maturation of SSU-rRNA, ribosomal small subunit biogenesis, ribosome biogenesis, single fertilization; MF: ATPase binding, RNA binding, U3 snoRNA binding, U4 snRNA binding, U4atac snRNA binding, box C/D sno(s)RNA binding, snoRNA binding; CC: U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U4atac snRNP, box C/D methylation guide snoRNP complex, dense fibrillar component, nucleolus, nucleus, plasma membrane, precatalytic spliceosome, protein-containing complex, ribonucleoprotein complex, small-subunit processome, spliceosomal complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D0T1
Entrez ID: 20826
|
Does Knockout of Capn3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Capn3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Capn3 (calpain 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1 to G0 transition involved in cell differentiation, calcium-dependent self proteolysis, cellular response to calcium ion, cellular response to salt stress, muscle structure development, myofibril assembly, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of protein sumoylation, negative regulation of skeletal muscle cell differentiation, positive regulation of DNA-templated transcription, positive regulation of proteolysis, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of satellite cell activation involved in skeletal muscle regeneration, programmed cell death, protein catabolic process, protein destabilization, protein localization to membrane, protein-containing complex assembly, proteolysis, regulation of canonical NF-kappaB signal transduction, regulation of myoblast differentiation, response to calcium ion, response to muscle activity, sarcomere organization, self proteolysis, sodium-dependent self proteolysis; MF: calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, catalytic activity, cysteine-type peptidase activity, enzyme binding, hydrolase activity, identical protein binding, ligase regulator activity, metal ion binding, molecular adaptor activity, peptidase activity, protein binding, signaling receptor binding, sodium ion binding, structural constituent of muscle, titin binding; CC: T-tubule, Z disc, cytoplasm, cytosol, myofibril, nucleolus, nucleus, plasma membrane, protein-containing complex
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization
UniProt: Q64691
Entrez ID: 12335
|
Does Knockout of Cma1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Cma1
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Cma1 (chymase 1, mast cell)
Type: protein-coding
Summary: This gene encodes a serine protease that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. The encoded preproprotein undergoes proteolytic processing to generate a functional enzyme with elastase-like activity. Mice lacking the encoded protein exhibit significant attenuation of ischemia-reperfusion injury of the skeletal muscle. This gene is located in a cluster of related mast cell protease genes on chromosome 14. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: basement membrane disassembly, cytokine precursor processing, extracellular matrix disassembly, positive regulation of angiogenesis, protein catabolic process, protein maturation, protein processing, proteolysis, regulation of inflammatory response; MF: endopeptidase activity, hydrolase activity, peptidase activity, peptide binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasmic ribonucleoprotein granule, cytosol, extracellular region, extracellular space, secretory granule
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Diabetic cardiomyopathy - Mus musculus (mouse), Extracellular matrix organization, Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Peptide hormone metabolism, Renin-angiotensin system - Mus musculus (mouse), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT
UniProt: P21844
Entrez ID: 17228
|
Does Knockout of Wdr53 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Wdr53
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Wdr53 (WD repeat domain 53)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DB94
Entrez ID: 68980
|
Does Knockout of Chn1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Chn1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Chn1 (chimerin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ephrin receptor signaling pathway, motor neuron axon guidance, nervous system development, regulation of GTPase activity, regulation of axonogenesis, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity, ephrin receptor binding, metal ion binding, protein binding, zinc ion binding
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q91V57
Entrez ID: 108699
|
Does Knockout of Wfdc6a in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Wfdc6a
|
cell proliferation
|
Regulatory T cell
|
Gene: Wfdc6a (WAP four-disulfide core domain 6A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q3UW55
Entrez ID: 209351
|
Does Knockout of Dnase1l1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Dnase1l1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Dnase1l1 (deoxyribonuclease 1-like 1)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human DNASE1L1 (deoxyribonuclease 1 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA catabolic process, DNA metabolic process; MF: DNA binding, DNA nuclease activity, catalytic activity, deoxyribonuclease I activity, endonuclease activity, hydrolase activity, nuclease activity; CC: endoplasmic reticulum, nucleus
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q9D7J6
Entrez ID: 69537
|
Does Knockout of 1600012H06Rik in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
1600012H06Rik
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: 1600012H06Rik (RIKEN cDNA 1600012H06 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, biological_process
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q9DAY5
Entrez ID: 67912
|
Does Knockout of Wif1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Wif1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Wif1 (Wnt inhibitory factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of Wnt signaling pathway, positive regulation of fat cell differentiation; MF: Wnt-protein binding, signaling receptor binding; CC: cell surface, extracellular region
Pathways: Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q9WUA1
Entrez ID: 24117
|
Does Knockout of Arhgap15 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Arhgap15
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Arhgap15 (Rho GTPase activating protein 15)
Type: protein-coding
Summary: The protein encoded by this gene is a RAC GTPase-activating protein that is regulated through its PH domain and by recruitment to the membrane. The protein accelerates hydrolysis of guanosine triphosphate to guanosine diphosphate to repress Rac activity. Knock-out of Arhgap15 function demonstrates that this gene is required to regulate multiple functions in macrophages and neutrophils. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: regulation of cell shape, signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity; CC: cytoplasm, membrane, nucleoplasm, plasma membrane
Pathways: RAC1 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q811M1
Entrez ID: 76117
|
Does Knockout of Dram1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Dram1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dram1 (DNA-damage regulated autophagy modulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, autophagy, cellular response to oxygen-glucose deprivation, regulation of autophagy; CC: cytoplasm, lysosomal membrane, lysosome, membrane
Pathways:
UniProt: Q9DC58
Entrez ID: 71712
|
Does Knockout of Cenpi in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Cenpi
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cenpi (centromere protein I)
Type: protein-coding
Summary: This gene encodes a protein that may be constitutively associated with centromeres and might be involved in recruiting centromere protein A to the centromere for kinetochore assembly. A similar gene in human is involved in the response of gonadal tissues to follicle-stimulating hormone. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: CENP-A containing chromatin assembly, biological_process, centromere complex assembly, chromosome segregation, mitotic sister chromatid segregation; CC: chromosome, chromosome, centromeric region, inner kinetochore, kinetochore, nuclear body, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8K1K4
Entrez ID: 102920
|
Does Knockout of Gm3543 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm3543
|
phagocytosis
|
macrophage
|
Gene: Gm3543 (predicted gene 3543)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Hsdl2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Hsdl2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Hsdl2 (hydroxysteroid dehydrogenase like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cholesterol homeostasis; MF: molecular_function, oxidoreductase activity; CC: mitochondrion, peroxisome
Pathways:
UniProt: Q2TPA8
Entrez ID: 72479
|
Does Knockout of Ptbp3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Ptbp3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ptbp3 (polypyrimidine tract binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cell differentiation, erythrocyte maturation, mRNA processing, negative regulation of RNA splicing, negative regulation of mRNA splicing, via spliceosome, regulation of RNA splicing, regulation of cell differentiation; MF: RNA binding, mRNA binding, nucleic acid binding; CC: nucleus
Pathways:
UniProt: Q8BHD7
Entrez ID: 230257
|
Does Knockout of Ccnd1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,565
|
Knockout
|
Ccnd1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ccnd1 (cyclin D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, G1/S transition of mitotic cell cycle, Leydig cell differentiation, Wnt signaling pathway, animal organ regeneration, cell division, cell population proliferation, cellular response to hypoxia, endoplasmic reticulum unfolded protein response, fat cell differentiation, lactation, liver development, liver regeneration, mammary gland alveolus development, mammary gland epithelial cell proliferation, mitotic G1 DNA damage checkpoint signaling, negative regulation of epithelial cell differentiation, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, neuron differentiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of mammary gland epithelial cell proliferation, re-entry into mitotic cell cycle, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, response to UV-A, response to X-ray, response to calcium ion, response to corticosterone, response to estradiol, response to estrogen, response to ethanol, response to glucocorticoid, response to iron ion, response to leptin, response to magnesium ion, response to steroid hormone, response to vitamin E, response to xenobiotic stimulus; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, histone deacetylase binding, kinase activity, proline-rich region binding, protein binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activator activity, protein-containing complex binding, transcription corepressor activity; CC: bicellular tight junction, cyclin D1-CDK4 complex, cyclin D1-CDK6 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, membrane, microtubule organizing center, nuclear membrane, nucleoplasm, nucleus, transcription repressor complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Alcoholic liver disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chromatin modifying enzymes, Chromatin organization, Chronic myeloid leukemia - Mus musculus (mouse), Co-inhibition by PD-1, Colorectal cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Drug-mediated inhibition of CDK4/CDK6 activity, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G1 Phase, G1/S Transition, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glioma - Mus musculus (mouse), Hedgehog signaling pathway - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Non-small cell lung cancer - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PTK6 Regulates Cell Cycle, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX3 regulates p14-ARF, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of RUNX1 Expression and Activity, Regulation of T cell activation by CD28 family, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Small cell lung cancer - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Ubiquitin-dependent degradation of Cyclin D, Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P25322
Entrez ID: 12443
|
Does Knockout of Mcm8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Mcm8
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mcm8 (minichromosome maintenance 8 homologous recombination repair factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, double-strand break repair via homologous recombination, female gamete generation, male gamete generation, protein localization to chromatin, protein stabilization, recombinational interstrand cross-link repair; MF: ATP binding, ATP hydrolysis activity, DNA binding, MutLbeta complex binding, MutSalpha complex binding, MutSbeta complex binding, chromatin binding, enzyme binding, helicase activity, hydrolase activity, nucleotide binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: MCM complex, MCM8-MCM9 complex, chromosome, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, CDC6 association with the ORC:origin complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: Q9CWV1
Entrez ID: 66634
|
Does Knockout of Polg2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 163
|
Knockout
|
Polg2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Polg2 (polymerase (DNA directed), gamma 2, accessory subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA repair, DNA replication, DNA-templated DNA replication, in utero embryonic development, mitochondrial DNA metabolic process, mitochondrial DNA replication, mitochondrion organization; MF: DNA binding, DNA polymerase binding, DNA polymerase processivity factor activity, DNA-directed DNA polymerase activity, double-stranded DNA binding, identical protein binding; CC: cytoplasm, gamma DNA polymerase complex, mitochondrial matrix, mitochondrial nucleoid, mitochondrion
Pathways: DNA Replication, Strand-asynchronous mitochondrial DNA replication
UniProt: Q9QZM2
Entrez ID: 50776
|
Does Knockout of Zfp790 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Zfp790
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp790 (zinc finger protein 790)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q80ZX2
Entrez ID: 233056
|
Does Knockout of Aggf1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Aggf1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Aggf1 (angiogenic factor with G patch and FHA domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell adhesion, cell differentiation, positive regulation of angiogenesis, positive regulation of endothelial cell proliferation; MF: identical protein binding, nucleic acid binding; CC: cytoplasm, extracellular region, perinuclear region of cytoplasm
Pathways:
UniProt: Q7TN31
Entrez ID: 66549
|
Does Knockout of Adora3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Adora3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Adora3 (adenosine A3 receptor)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. This gene shares its 3' terminal exon with a transcript variant from overlapping GeneID:69296, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: G protein-coupled adenosine receptor signaling pathway, G protein-coupled receptor signaling pathway, histamine secretion by mast cell, negative regulation of cell migration, negative regulation of cell population proliferation, positive regulation of calcium-mediated signaling, positive regulation of inflammatory response, positive regulation of leukocyte migration, positive regulation of mast cell degranulation, positive regulation of mucus secretion, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, presynaptic modulation of chemical synaptic transmission, regulation of cell communication, regulation of norepinephrine secretion, regulation of signaling, signal transduction; MF: G protein-coupled adenosine receptor activity, G protein-coupled receptor activity; CC: Schaffer collateral - CA1 synapse, dendrite, membrane, neuromuscular junction, plasma membrane, presynaptic membrane, synapse
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q497R5, Q3U4C5
Entrez ID: 11542
|
Does Knockout of Neurod6 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,195
|
Knockout
|
Neurod6
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Neurod6 (neurogenic differentiation 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, cell differentiation, central nervous system development, dentate gyrus development, nervous system development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, sensory organ development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity; CC: nucleus
Pathways:
UniProt: P48986
Entrez ID: 11922
|
Does Knockout of Atf5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Atf5
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Atf5 (activating transcription factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellar granule cell precursor proliferation, circadian rhythm, fat cell differentiation, multicellular organism growth, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of astrocyte differentiation, negative regulation of cell cycle G2/M phase transition, negative regulation of cell population proliferation, negative regulation of neurogenesis, olfactory bulb interneuron development, olfactory bulb interneuron differentiation, olfactory lobe development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, post-embryonic development, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of centrosome cycle, regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, heat shock protein binding, kinase binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding, tubulin binding; CC: RNA polymerase II transcription regulator complex, centrosome, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: O70191
Entrez ID: 107503
|
Does Knockout of Cttnbp2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Cttnbp2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Cttnbp2 (cortactin binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of modification of postsynaptic actin cytoskeleton, regulation of synapse organization; MF: SH3 domain binding, protein binding; CC: FAR/SIN/STRIPAK complex, cell cortex, cell projection, cytoplasm, dendritic spine, glutamatergic synapse, postsynaptic actin cytoskeleton, synapse, synaptic vesicle
Pathways:
UniProt: B9EJA2
Entrez ID: 30785
|
Does Knockout of Gdap2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Gdap2
|
cell cycle progression
|
breast epithelium
|
Gene: Gdap2 (ganglioside-induced differentiation-associated-protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DBL2
Entrez ID: 14547
|
Does Knockout of Ndel1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Ndel1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Ndel1 (nudE neurodevelopment protein 1 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical Wnt signaling pathway, cell differentiation, cell migration, central nervous system neuron axonogenesis, centrosome localization, cerebral cortex radially oriented cell migration, chromosome localization, chromosome segregation, establishment of mitotic spindle orientation, inner cell mass cell proliferation, insulin receptor signaling pathway, lysosome localization, microtubule cytoskeleton organization, microtubule nucleation, mitotic centrosome separation, nervous system development, neurofilament cytoskeleton organization, neuron migration, neuron projection development, neuron projection extension, nuclear membrane disassembly, positive regulation of axon extension, positive regulation of axon regeneration, positive regulation of ruffle assembly, radial glia-guided pyramidal neuron migration, regulation of intracellular protein transport, regulation of neuron projection development, retrograde axonal transport, vesicle transport along microtubule; MF: alpha-tubulin binding, beta-tubulin binding, identical protein binding, microtubule binding, oligopeptidase activity, protein binding, protein-containing complex binding; CC: axon, axon cytoplasm, axon hillock, cell body, cell leading edge, central region of growth cone, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, kinesin complex, kinetochore, microtubule, microtubule associated complex, microtubule organizing center, neurofilament cytoskeleton, nuclear envelope, spindle, synaptic vesicle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9ERR1
Entrez ID: 83431
|
Does Knockout of Ankrd13d in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Ankrd13d
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Ankrd13d (ankyrin repeat domain 13 family, member D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of receptor internalization; MF: ubiquitin-modified protein reader activity; CC: cytoplasm, endosome, late endosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q6PD24
Entrez ID: 68423
|
Does Knockout of Arpc3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Arpc3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Arpc3 (actin related protein 2/3 complex, subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, regulation of actin filament polymerization, regulation of synaptic vesicle endocytosis; MF: actin binding, actin filament binding, protein binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, cell leading edge, cell projection, cytoplasm, cytoskeleton, filamentous actin, growth cone leading edge, lamellipodium, nucleus, site of double-strand break
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: Q9JM76
Entrez ID: 56378
|
Does Knockout of Abcb4 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Abcb4
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Abcb4 (ATP-binding cassette, sub-family B member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid secretion, cellular response to bile acid, lipid homeostasis, lipid transport, phospholipid translocation, positive regulation of cholesterol transport, positive regulation of phospholipid translocation, positive regulation of phospholipid transport, response to fenofibrate, transmembrane transport, xenobiotic transmembrane transport; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, ATPase-coupled transmembrane transporter activity, nucleotide binding, phosphatidylcholine floppase activity; CC: Golgi membrane, apical plasma membrane, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, focal adhesion, intercellular canaliculus, membrane, membrane raft, nucleoplasm, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC-family proteins mediated transport, Bile secretion - Mus musculus (mouse), Transport of small molecules
UniProt: P21440
Entrez ID: 18670
|
Does Knockout of Atp2a2 in Regulatory T cell causally result in protein/peptide accumulation?
| 1
| 1,481
|
Knockout
|
Atp2a2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Atp2a2 (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ER-nucleus signaling pathway, T-tubule organization, autophagosome assembly, autophagosome membrane docking, calcium ion import into sarcoplasmic reticulum, calcium ion transmembrane transport, calcium ion transport, calcium ion transport from cytosol to endoplasmic reticulum, cardiac muscle hypertrophy in response to stress, cellular response to oxidative stress, endoplasmic reticulum calcium ion homeostasis, intracellular calcium ion homeostasis, mitochondrion-endoplasmic reticulum membrane tethering, monoatomic ion transport, muscle system process, negative regulation of heart contraction, neuron cellular homeostasis, organelle localization by membrane tethering, positive regulation of cardiac muscle cell apoptotic process, positive regulation of endoplasmic reticulum calcium ion concentration, regulation of calcium ion-dependent exocytosis of neurotransmitter, regulation of cardiac muscle cell action potential involved in regulation of contraction, regulation of cardiac muscle cell membrane potential, regulation of cardiac muscle contraction by calcium ion signaling, regulation of heart contraction, regulation of muscle contraction, regulation of the force of heart contraction, relaxation of cardiac muscle, response to peptide hormone, sarcoplasmic reticulum calcium ion transport, transition between fast and slow fiber; MF: ATP binding, ATP hydrolysis activity, P-type calcium transporter activity, P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential, S100 protein binding, calcium channel regulator activity, calcium ion binding, enzyme binding, lncRNA binding, lutropin-choriogonadotropic hormone receptor binding, metal ion binding, nucleotide binding, protein binding, transmembrane transporter binding; CC: apical ectoplasmic specialization, calcium ion-transporting ATPase complex, endoplasmic reticulum, endoplasmic reticulum membrane, extrinsic component of cytoplasmic side of plasma membrane, intercalated disc, longitudinal sarcoplasmic reticulum, membrane, perinuclear region of cytoplasm, plasma membrane bounded cell projection, protein-containing complex, ribbon synapse, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hemostasis, Hypertrophic cardiomyopathy - Mus musculus (mouse), Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Muscle contraction, Pancreatic secretion - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Platelet calcium homeostasis, Platelet homeostasis, Reduction of cytosolic Ca++ levels, Spinocerebellar ataxia - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Transport of small molecules, cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: O55143
Entrez ID: 11938
|
Does Knockout of Efhd2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Efhd2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Efhd2 (EF hand domain containing 2)
Type: protein-coding
Summary: Enables calcium ion binding activity. Predicted to be located in membrane raft. Is expressed in brain; embryo endoderm; extraembryonic component; gut; and heart. Orthologous to human EFHD2 (EF-hand domain family member D2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: calcium ion binding, metal ion binding, protein binding; CC: membrane, membrane raft
Pathways:
UniProt: Q8C845
Entrez ID: 27984
|
Does Knockout of A630073D07Rik in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
A630073D07Rik
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: A630073D07Rik (RIKEN cDNA A630073D07 gene)
Type: protein-coding
Summary: RIKEN cDNA A630073D07 gene
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: E9PWS6
Entrez ID: 381819
|
Does Knockout of Tmem161b in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Tmem161b
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Tmem161b (transmembrane protein 161B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of cardiac muscle cell action potential, regulation of heart rate; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q8C2L6
Entrez ID: 72745
|
Does Knockout of Rhobtb2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Rhobtb2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rhobtb2 (Rho-related BTB domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, cortical cytoskeleton organization, establishment or maintenance of cell polarity, protein ubiquitination, regulation of actin cytoskeleton organization, regulation of cell shape, signal transduction, small GTPase-mediated signal transduction, ubiquitin-dependent protein catabolic process; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cell projection, cytoplasmic vesicle, cytoskeleton, endosome membrane, plasma membrane
Pathways: RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q91V93
Entrez ID: 246710
|
Does Knockout of Togaram2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Togaram2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Togaram2 (TOG array regulator of axonemal microtubules 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, negative regulation of cytoskeleton organization, negative regulation of supramolecular fiber organization; MF: microtubule binding; CC: cilium, cytoplasmic microtubule, microtubule cytoskeleton
Pathways:
UniProt: Q3TYG6
Entrez ID: 320159
|
Does Knockout of Cnppd1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Cnppd1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cnppd1 (cyclin Pas1/PHO80 domain containing 1)
Type: protein-coding
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be located in membrane. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human CNPPD1 (cyclin Pas1/PHO80 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: cyclin-dependent protein serine/threonine kinase regulator activity, protein kinase binding; CC: cyclin-dependent protein kinase holoenzyme complex, membrane, nucleus
Pathways:
UniProt: Q8K158
Entrez ID: 69171
|
Does Knockout of Hhatl in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Hhatl
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Hhatl (hedgehog acyltransferase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of N-terminal protein palmitoylation, regulation of protein modification process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, perinuclear region of cytoplasm
Pathways: Hedgehog signaling pathway - Mus musculus (mouse)
UniProt: Q9D1G3
Entrez ID: 74770
|
Does Knockout of Cpz in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Cpz
|
cell cycle progression
|
breast epithelium
|
Gene: Cpz (carboxypeptidase Z)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, peptide metabolic process, protein processing, proteolysis; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: Q8R4V4
Entrez ID: 242939
|
Does Knockout of Tshz2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Tshz2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tshz2 (teashirt zinc finger family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q68FE9
Entrez ID: 228911
|
Does Knockout of Ddit3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Ddit3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ddit3 (DNA-damage inducible transcript 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ER overload response, GDF15-GFRAL signaling pathway, HRI-mediated signaling, Wnt signaling pathway, anterior/posterior axis specification, apoptotic process, artery development, blood vessel maturation, calcium ion import, cell redox homeostasis, diaphragm contraction, endoplasmic reticulum unfolded protein response, establishment of protein localization to mitochondrion, gene expression, integrated stress response signaling, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, intrinsic apoptotic signaling pathway in response to nitrosative stress, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, negative regulation of cold-induced thermogenesis, negative regulation of determination of dorsal identity, negative regulation of fat cell differentiation, negative regulation of interleukin-17 production, negative regulation of interleukin-4 production, negative regulation of myoblast differentiation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of transcription by RNA polymerase II, negative regulation of type II interferon production, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of autophagy in response to ER overload, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of interleukin-8 production, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of neuron apoptotic process, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of DNA-templated transcription, regulation of autophagy, regulation of cell cycle, regulation of transcription by RNA polymerase II, release of sequestered calcium ion into cytosol, response to caloric restriction, response to endoplasmic reticulum stress, response to platelet-derived growth factor, response to starvation, response to unfolded protein, response to wounding, sensory perception of sound, vascular associated smooth muscle cell migration, vascular associated smooth muscle cell proliferation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding protein binding, identical protein binding, leucine zipper domain binding, protein binding, protein heterodimerization activity, protein homodimerization activity, sequence-specific DNA binding, transcription cis-regulatory region binding, transcription corepressor activity, transcription regulator activator activity, transcription regulator inhibitor activity; CC: CHOP-ATF3 complex, CHOP-ATF4 complex, CHOP-C/EBP complex, RNA polymerase II transcription regulator complex, cytoplasm, late endosome, nucleoplasm, nucleus, protein-DNA complex
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P35639
Entrez ID: 13198
|
Does Knockout of Lpar4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Lpar4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lpar4 (lysophosphatidic acid receptor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, lipid binding, lysophosphatidic acid binding, lysophosphatidic acid receptor activity; CC: membrane, nuclear body, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nucleotide-like (purinergic) receptors, P2Y receptors, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q8BLG2
Entrez ID: 78134
|
Does Knockout of Tbp in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Tbp
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tbp (TATA box binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase I preinitiation complex assembly, RNA polymerase II preinitiation complex assembly, mRNA transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription initiation by RNA polymerase II, transcription by RNA polymerase II, transcription by RNA polymerase III; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase I core promoter sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, RNA polymerase III general transcription initiation factor activity, TFIIB-class transcription factor binding, aryl hydrocarbon receptor binding, core promoter sequence-specific DNA binding, enzyme binding, protein binding, transcription cis-regulatory region binding; CC: RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, chromatin, cytoplasm, cytosol, euchromatin, female germ cell nucleus, female pronucleus, male germ cell nucleus, male pronucleus, nucleoplasm, nucleus, pronucleus, protein-containing complex, transcription factor TFIIA complex, transcription factor TFIID complex
Pathways: B-WICH complex positively regulates rRNA expression, Basal transcription factors - Mus musculus (mouse), ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Signaling by Nuclear Receptors, Spinocerebellar ataxia - Mus musculus (mouse), Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse)
UniProt: P29037
Entrez ID: 21374
|
Does Knockout of Defb43 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Defb43
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Defb43 (defensin beta 43)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response, defense response to bacterium, innate immune response; CC: extracellular region, extracellular space
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q30KM9
Entrez ID: 654458
|
Does Knockout of Ubr1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Ubr1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ubr1 (ubiquitin protein ligase E3 component n-recognin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to L-leucine, negative regulation of TOR signaling, proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic process, protein ubiquitination, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the N-end rule pathway; MF: L-leucine binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, proteasome complex, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: O70481
Entrez ID: 22222
|
Does Knockout of Itih5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Itih5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Itih5 (inter-alpha-trypsin inhibitor, heavy chain 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, hyaluronan metabolic process, uterus development; MF: molecular_function, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular matrix, extracellular region
Pathways:
UniProt: Q8BJD1
Entrez ID: 209378
|
Does Knockout of Rnf122 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Rnf122
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rnf122 (ring finger protein 122)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of mitochondrial membrane potential, positive regulation of apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autoubiquitination; MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, endoplasmic reticulum, membrane
Pathways:
UniProt: Q8BP31
Entrez ID: 68867
|
Does Knockout of Ttpa in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Ttpa
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ttpa (tocopherol (alpha) transfer protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: embryonic placenta development, intermembrane lipid transfer, intracellular pH reduction, negative regulation of epithelial cell apoptotic process, negative regulation of establishment of blood-brain barrier, placenta development, positive regulation of amyloid-beta clearance, response to pH, response to toxic substance, vitamin E metabolic process, vitamin transport; MF: lipid binding, lipid transfer activity, phosphatidylinositol bisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-4,5-bisphosphate binding, vitamin E binding, vitamin binding; CC: cytoplasm, late endosome
Pathways: Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Vitamin E transport
UniProt: Q8BWP5
Entrez ID: 50500
|
Does Knockout of Tstd2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Tstd2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tstd2 (thiosulfate sulfurtransferase (rhodanese)-like domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3U269
Entrez ID: 272027
|
Does Knockout of Mlf2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Mlf2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mlf2 (myeloid leukemia factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, glutamatergic synapse, nucleus, synapse
Pathways:
UniProt: Q99KX1
Entrez ID: 30853
|
Does Knockout of Tat in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Tat
|
cell cycle progression
|
breast epithelium
|
Gene: Tat (tyrosine aminotransferase)
Type: protein-coding
Summary: This gene encodes a liver-specific mitochondrial enzyme that catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Regulated by glucocorticoid and polypeptide hormones, this gene's expression is affected by deletion of a regulatory region near the albino locus on chromosome 7. Mutations in this gene cause tyrosinemia type II in humans. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: 2-oxoglutarate metabolic process, L-phenylalanine catabolic process, L-tyrosine catabolic process, amino acid metabolic process, aromatic amino acid family catabolic process, aromatic amino acid metabolic process, cellular response to insulin stimulus, cellular response to retinoic acid, glutamate metabolic process, liver regeneration, response to cAMP, response to cortisol, response to dexamethasone, response to ethanol, response to glucocorticoid, response to mercury ion, response to oxidative stress; MF: L-tyrosine-2-oxoglutarate transaminase activity, amino acid binding, catalytic activity, identical protein binding, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytosol, mitochondrion
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Phenylalanine and tyrosine metabolism, Phenylalanine metabolism - Mus musculus (mouse), Phenylalanine, tyrosine and tryptophan biosynthesis - Mus musculus (mouse), Tyrosine catabolism, Tyrosine metabolism - Mus musculus (mouse), Ubiquinone and other terpenoid-quinone biosynthesis - Mus musculus (mouse), phenylalanine degradation III, tyrosine degradation I
UniProt: Q8QZR1
Entrez ID: 234724
|
Does Knockout of Cst13 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Cst13
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cst13 (cystatin 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: cysteine-type endopeptidase inhibitor activity, peptidase inhibitor activity; CC: cytoplasm, extracellular region
Pathways:
UniProt: Q80ZN5
Entrez ID: 69294
|
Does Knockout of Fam3a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Fam3a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fam3a (FAM3 metabolism regulating signaling molecule A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP biosynthetic process, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, calcium ion homeostasis, gene expression, glucose metabolic process, insulin secretion, mitochondrion organization, negative regulation of antifungal innate immune response, response to glucose; MF: carbohydrate binding, molecular_function; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9D8T0
Entrez ID: 66294
|
Does Knockout of Gltp in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Gltp
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gltp (glycolipid transfer protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide 1-phosphate transport, ceramide transport, intermembrane lipid transfer, lipid transport, response to immobilization stress; MF: ceramide 1-phosphate binding, ceramide 1-phosphate transfer activity, glycolipid binding, identical protein binding, lipid binding, lipid transfer activity; CC: cytoplasm, cytosol
Pathways: Glycosphingolipid transport, Transport of small molecules
UniProt: Q9JL62
Entrez ID: 56356
|
Does Knockout of Calcoco2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Calcoco2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Calcoco2 (calcium binding and coiled-coil domain 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, positive regulation of autophagosome maturation, response to type II interferon, xenophagy; CC: PML body, autophagosome, autophagosome membrane, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, membrane, perinuclear region of cytoplasm
Pathways: Influenza A - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse)
UniProt: A2A6M5
Entrez ID: 76815
|
Does Knockout of Gdf15 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Gdf15
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gdf15 (growth differentiation factor 15)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: GDF15-GFRAL signaling pathway, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to chemical stress, energy homeostasis, negative regulation of SMAD protein signal transduction, negative regulation of appetite, negative regulation of growth hormone receptor signaling pathway, negative regulation of leukocyte migration, negative regulation of multicellular organism growth, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of fatty acid oxidation, positive regulation of myoblast fusion, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, reduction of food intake in response to dietary excess, response to metformin; MF: cytokine activity, growth factor activity, hormone activity, protein homodimerization activity; CC: Golgi apparatus, cytoplasm, extracellular region, extracellular space, nucleus
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse)
UniProt: Q9Z0J7
Entrez ID: 23886
|
Does Knockout of Slc36a2 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Slc36a2
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Slc36a2 (solute carrier family 36 (proton/amino acid symporter), member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alanine transport, amino acid export across plasma membrane, glycine transport, positive regulation of glycine import across plasma membrane, proline transmembrane transport, proline transport, proton transmembrane transport, regulation of proline transport, regulation of proton transport; MF: L-alanine transmembrane transporter activity, L-proline transmembrane transporter activity, amino acid:proton symporter activity, glycine transmembrane transporter activity, proline:proton symporter activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endosome, membrane, plasma membrane, recycling endosome membrane, vacuolar membrane
Pathways: Amino acid transport across the plasma membrane, Protein digestion and absorption - Mus musculus (mouse), Proton-coupled neutral amino acid transporters, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules
UniProt: Q8BHK3
Entrez ID: 246049
|
Does Knockout of Inca1 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Inca1
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Inca1 (inhibitor of CDK, cyclin A1 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic signaling pathway, negative regulation of cell population proliferation, negative regulation of fibroblast proliferation, positive regulation of apoptotic signaling pathway; MF: cyclin binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, identical protein binding, protein binding, protein kinase inhibitor activity, protein-containing complex binding; CC: cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q6PKN7
Entrez ID: 103844
|
Does Knockout of Cldn11 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Cldn11
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cldn11 (claudin 11)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of CNS (central nervous system) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. The basal cell tight junctions in stria vascularis are primarily composed of this protein, and the gene-null mice suffer severe deafness. This protein is also an obligatory protein for tight junction formation and barrier integrity in the testis and the gene deficiency results in loss of the Sertoli cell epithelial phenotype in the testis. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: axon ensheathment, bicellular tight junction assembly, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion, spermatogenesis, tight junction assembly; MF: identical protein binding, protein binding, structural molecule activity; CC: anchoring junction, axon, basal part of cell, bicellular tight junction, cell junction, lipid droplet, membrane, myelin sheath, neurofilament, plasma membrane, tight junction
Pathways: Cell adhesion molecules - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: Q60771
Entrez ID: 18417
|
Does Knockout of 4930522H14Rik in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
4930522H14Rik
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: 4930522H14Rik (RIKEN cDNA 4930522H14 gene)
Type: protein-coding
Summary: Predicted to be located in membrane. Orthologous to human C1orf185 (chromosome 1 open reading frame 185). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q9CPZ3
Entrez ID: 67646
|
Does Knockout of Cts3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Cts3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cts3 (cathepsin 3)
Type: protein-coding
Summary: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in extraembryonic component; head; labyrinthine zone; and placenta. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: collagen catabolic process, fusion of virus membrane with host endosome membrane, fusion of virus membrane with host plasma membrane, protein autoprocessing, proteolysis, proteolysis involved in protein catabolic process, receptor-mediated endocytosis of virus by host cell, symbiont entry into host cell, zymogen activation; MF: collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, fibronectin binding, histone binding, hydrolase activity, peptidase activity, proteoglycan binding, serpin family protein binding; CC: Golgi apparatus, extracellular space, lysosome, multivesicular body, plasma membrane
Pathways:
UniProt: Q9DAZ8, Q91ZD5, A0A286YE21
Entrez ID: 117066
|
Does Knockout of Plat in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Plat
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Plat (plasminogen activator, tissue)
Type: protein-coding
Summary: This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: negative regulation of fibrinolysis, negative regulation of plasminogen activation, negative regulation of proteolysis, plasminogen activation, platelet-derived growth factor receptor signaling pathway, prevention of polyspermy, proteolysis, response to hypoxia, smooth muscle cell migration, synaptic transmission, glutamatergic, trans-synaptic signaling by BDNF, modulating synaptic transmission; MF: hydrolase activity, peptidase activity, phosphoprotein binding, serine-type endopeptidase activity, serine-type peptidase activity, signaling receptor binding; CC: Schaffer collateral - CA1 synapse, apical part of cell, cell surface, cytoplasm, extracellular region, extracellular space, glutamatergic synapse, neuronal dense core vesicle, perisynaptic space, postsynapse, secretory granule, serine protease inhibitor complex
Pathways: Apelin signaling pathway - Mus musculus (mouse), Complement and coagulation cascades - Mus musculus (mouse), Dissolution of Fibrin Clot, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hemostasis, Prostate cancer - Mus musculus (mouse), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P11214
Entrez ID: 18791
|
Does Knockout of Prop1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Prop1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Prop1 (paired like homeodomain factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenohypophysis development, animal organ morphogenesis, blood vessel development, cell migration, dorsal/ventral pattern formation, gland development, hypophysis morphogenesis, hypothalamus cell differentiation, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, nervous system development, pituitary gland development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, somatotropin secreting cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, beta-catenin binding, chromatin binding, protein binding, sequence-specific double-stranded DNA binding; CC: nucleus, transcription regulator complex
Pathways:
UniProt: P97458
Entrez ID: 19127
|
Does Knockout of Lrrc51 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Lrrc51
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lrrc51 (leucine rich repeat containing 51)
Type: protein-coding
Summary: Predicted to be located in cytoplasm. Predicted to be active in axoneme. Is expressed in brain; gut gland; nasal cavity respiratory epithelium; respiratory system; and testis. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to several human genes including LRRC51 (leucine rich repeat containing 51). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: axoneme, cellular_component, cytoplasm
Pathways:
UniProt: Q9DAK8
Entrez ID: 69358
|
Does Knockout of Usp49 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Usp49
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Usp49 (ubiquitin specific peptidase 49)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, chromatin organization, chromatin remodeling, mRNA processing, mRNA splicing, via spliceosome, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol 3-kinase/protein kinase B signal transduction, protein deubiquitination, proteolysis; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, histone H2B deubiquitinase activity, histone binding, hydrolase activity, metal ion binding, peptidase activity, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q6P9L4
Entrez ID: 224836
|
Does Knockout of Ube2h in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Ube2h
|
phagocytosis
|
macrophage
|
Gene: Ube2h (ubiquitin-conjugating enzyme E2H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P62257
Entrez ID: 22214
|
Does Knockout of Tm6sf2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Tm6sf2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tm6sf2 (transmembrane 6 superfamily member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid homeostasis, regulation of lipid metabolic process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane
Pathways:
UniProt: Q8R1J1
Entrez ID: 107770
|
Does Knockout of Nek4 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Nek4
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Nek4 (NIMA (never in mitosis gene a)-related expressed kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cell division, mitotic cell cycle, positive regulation of DNA-templated transcription, protein phosphorylation, regulation of cellular senescence; MF: ATP binding, kinase activity, manganese ion binding, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, ciliary basal body, ciliary plasm, ciliary rootlet, ciliary transition zone, cilium, cytoplasm, cytosol
Pathways:
UniProt: Q9Z1J2
Entrez ID: 23955
|
Does Knockout of Klhl20 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Klhl20
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Klhl20 (kelch-like 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to endosome transport, negative regulation of apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K33-linked ubiquitination, protein transport, protein ubiquitination; MF: actin binding, type II interferon binding, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activity; CC: Cul3-RING ubiquitin ligase complex, Golgi apparatus, PML body, axon, cell projection, cytoplasm, cytosol, dendrite, nucleus, perinuclear region of cytoplasm, trans-Golgi network
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q8VCK5
Entrez ID: 226541
|
Does Knockout of Smim13 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Smim13
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Smim13 (small integral membrane protein 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: E9Q942
Entrez ID: 108934
|
Does Knockout of Abcf3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Abcf3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Abcf3 (ATP-binding cassette, sub-family F member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, nucleotide binding, protein binding
Pathways:
UniProt: Q8K268
Entrez ID: 27406
|
Does Knockout of Vmn2r9 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Vmn2r9
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Vmn2r9 (vomeronasal 2, receptor 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2W817, K7N6Z8
Entrez ID: 435864
|
Does Knockout of Qsox2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Qsox2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Qsox2 (quiescin Q6 sulfhydryl oxidase 2)
Type: protein-coding
Summary: This gene encodes a member of the sulfhydryl oxidase protein family. Members of this family catalyze formation of disulfide bonds. A similar protein in humans may sensitize neuroblastoma cells to interferon gamma-induced cell death. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Gene Ontology: MF: flavin-dependent sulfhydryl oxidase activity, oxidoreductase activity, protein disulfide isomerase activity, thiol oxidase activity; CC: Golgi apparatus, Golgi membrane, extracellular space, membrane, nucleoplasm
Pathways:
UniProt: Q3TMX7
Entrez ID: 227638
|
Does Knockout of Ppdpf in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Ppdpf
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ppdpf (pancreatic progenitor cell differentiation and proliferation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TOR signaling, TORC1 signaling, cell differentiation, liver development
Pathways:
UniProt: Q9CR37
Entrez ID: 66496
|
Does Knockout of Tmem62 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Tmem62
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmem62 (transmembrane protein 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, molecular_function; CC: cellular_component, membrane
Pathways:
UniProt: Q8BXJ9
Entrez ID: 96957
|
Does Knockout of Icam5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Icam5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Icam5 (intercellular adhesion molecule 5, telencephalin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion, phagocytosis, regulation of synapse assembly; MF: integrin binding, protein binding; CC: glutamatergic synapse, membrane, plasma membrane, postsynapse
Pathways: Adaptive Immune System, Extracellular matrix organization, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Integrin cell surface interactions
UniProt: Q60625
Entrez ID: 15898
|
Does Knockout of Ino80 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,411
|
Knockout
|
Ino80
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Ino80 (INO80 complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA recombination, DNA repair, DNA-templated transcription, UV-damage excision repair, cell division, cellular response to UV, cellular response to ionizing radiation, chromatin remodeling, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, mitotic sister chromatid segregation, positive regulation of DNA metabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of cell growth, positive regulation of nuclear cell cycle DNA replication, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, spindle assembly, telomere maintenance; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent chromatin remodeler activity, DNA binding, actin binding, alpha-tubulin binding, histone binding, hydrolase activity, nucleotide binding; CC: Ino80 complex, chromosome, cytoplasm, cytoskeleton, cytosol, microtubule, nuclear body, nucleoplasm, nucleus, spindle
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q6ZPV2
Entrez ID: 68142
|
Does Knockout of Gm15103 in Microglial Cell Line causally result in cell proliferation?
| 0
| 1,358
|
Knockout
|
Gm15103
|
cell proliferation
|
Microglial Cell Line
|
Gene: Gm15103 (ovary testis transcribed pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100039669
|
Does Knockout of Trim24 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Trim24
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Trim24 (tripartite motif-containing 24)
Type: protein-coding
Summary: The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: calcium ion homeostasis, cellular response to estrogen stimulus, chromatin organization, negative regulation of DNA-templated transcription, negative regulation of epithelial cell proliferation, positive regulation of DNA-templated transcription, positive regulation of gene expression, protein catabolic process, protein ubiquitination, regulation of apoptotic process, regulation of protein stability, regulation of signal transduction by p53 class mediator, regulation of vitamin D receptor signaling pathway, response to peptide hormone; MF: DNA binding, chromatin binding, estrogen response element binding, histone H3K23ac reader activity, metal ion binding, nuclear receptor binding, p53 binding, protein binding, protein kinase activity, sequence-specific DNA binding, transcription coactivator activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: chromatin, cytoplasm, euchromatin, male germ cell nucleus, nuclear lumen, nucleoplasm, nucleus, perichromatin fibrils
Pathways:
UniProt: Q64127
Entrez ID: 21848
|
Does Knockout of Nt5e in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Nt5e
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nt5e (5' nucleotidase, ecto)
Type: protein-coding
Summary: This gene encodes a membrane-bound nucleotidase that hydrolyzes extracellular nucleoside monophosphates. The encoded preproprotein undergoes proteolytic processing to generate to a functional, homodimeric enzyme that preferentially uses adenosine monophosphate as a substrate to generate free adenosine. Mice lacking the encoded protein exhibit a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: ADP catabolic process, AMP catabolic process, ATP metabolic process, adenosine biosynthetic process, adenosine metabolic process, calcium ion homeostasis, inhibition of non-skeletal tissue mineralization, leukocyte cell-cell adhesion, negative regulation of inflammatory response, nucleotide catabolic process, response to ATP; MF: 5'-deoxynucleotidase activity, 5'-nucleotidase activity, ferrous iron binding, hydrolase activity, hydrolase activity, acting on ester bonds, identical protein binding, metal ion binding, nucleotide binding, zinc ion binding; CC: cell surface, cytosol, external side of plasma membrane, membrane, nucleoplasm, plasma membrane, side of membrane, synaptic membrane
Pathways: Metabolism, Metabolism of nucleotides, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nicotinate metabolism, Nucleotide catabolism, Purine catabolism, Purine metabolism - Mus musculus (mouse), Pyrimidine catabolism, Pyrimidine metabolism - Mus musculus (mouse), purine nucleotides degradation II (aerobic), urate biosynthesis/inosine 5,-phosphate degradation, ureide biosynthesis
UniProt: Q61503
Entrez ID: 23959
|
Does Knockout of Gm5544 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Gm5544
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gm5544 (predicted gene 5544)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UQK6
Entrez ID: 433632
|
Does Knockout of Lrch1 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Lrch1
|
response to bacteria
|
macrophage
|
Gene: Lrch1 (leucine-rich repeats and calponin homology (CH) domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to chemokine, negative regulation of GTPase activity, negative regulation of T cell migration; CC: cytoplasm
Pathways:
UniProt: P62046
Entrez ID: 380916
|
Does Knockout of Sh3bp5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Sh3bp5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sh3bp5 (SH3-domain binding protein 5 (BTK-associated))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, negative regulation of protein kinase activity; MF: SH3 domain binding, guanyl-nucleotide exchange factor activity, protein kinase inhibitor activity; CC: cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, mitochondrion, nuclear body, nucleoplasm
Pathways:
UniProt: Q9Z131
Entrez ID: 24056
|
Does Knockout of Slc7a11 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Slc7a11
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc7a11 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-cystine transport, L-glutamate import across plasma membrane, L-glutamate transmembrane transport, L-kynurenine transmembrane transport, adult behavior, amino acid transmembrane transport, amino acid transport, brain development, cellular response to oxidative stress, cellular response to stress, dipeptide import across plasma membrane, glutathione metabolic process, glutathione transmembrane transport, intracellular glutamate homeostasis, limb development, lung alveolus development, lysosomal lumen pH elevation, modulation of chemical synaptic transmission, negative regulation of ferroptosis, platelet aggregation, proton transmembrane transport, regulation of AMPA glutamate receptor clustering, regulation of cell population proliferation, regulation of cellular response to oxidative stress, regulation of cysteine metabolic process, regulation of glutamate metabolic process, regulation of glutathione biosynthetic process, regulation of melanin biosynthetic process, regulation of neutrophil apoptotic process, regulation of programmed cell death, regulation of protein transport, regulation of synapse organization, response to redox state, response to toxic substance, striatum development, transmembrane transport, ventricular system development, visual learning; MF: L-amino acid transmembrane transporter activity, L-kynurenine transmembrane transporter activity, cystine:glutamate antiporter activity, leak channel activity, proton channel activity, transmembrane transporter activity; CC: apical part of cell, astrocyte projection, brush border membrane, cell projection, cell surface, lysosomal membrane, membrane, microvillus membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, Basigin interactions, Cell surface interactions at the vascular wall, Ferroptosis - Mus musculus (mouse), Hemostasis, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules
UniProt: Q9WTR6
Entrez ID: 26570
|
Does Knockout of Mup20 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Mup20
|
phagocytosis
|
macrophage
|
Gene: Mup20 (major urinary protein 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: olfactory learning, positive regulation of neural precursor cell proliferation, positive regulation of neurogenesis, signal transduction, vocalization behavior; MF: mating pheromone activity, odorant binding, pheromone activity, pheromone binding, small molecule binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q5FW60
Entrez ID: 381530
|
Does Knockout of Dhx34 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Dhx34
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dhx34 (DExH-box helicase 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of phosphorylation; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein-containing complex binding
Pathways:
UniProt: Q9DBV3
Entrez ID: 71723
|
Does Knockout of Awat2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Awat2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Awat2 (acyl-CoA wax alcohol acyltransferase 2)
Type: protein-coding
Summary: Enables retinol O-fatty-acyltransferase activity. Acts upstream of or within wax biosynthetic process. Located in endoplasmic reticulum membrane. Used to study dry eye syndrome. Orthologous to human AWAT2 (acyl-CoA wax alcohol acyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lipid metabolic process, monoacylglycerol biosynthetic process, retinol metabolic process, wax biosynthetic process; MF: 2-acylglycerol O-acyltransferase activity, O-acyltransferase activity, acyltransferase activity, diacylglycerol O-acyltransferase activity, long-chain-alcohol O-fatty-acyltransferase activity, retinol O-fatty-acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Acyl chain remodeling of DAG and TAG, Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Retinol metabolism - Mus musculus (mouse), Sensory Perception, The retinoid cycle in cones (daylight vision), Visual phototransduction, Vitamin digestion and absorption - Mus musculus (mouse), Wax and plasmalogen biosynthesis, Wax biosynthesis, wax esters biosynthesis I
UniProt: Q6E1M8
Entrez ID: 245532
|
Does Knockout of Prr18 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Prr18
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Prr18 (proline rich 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6PAN7
Entrez ID: 320111
|
Does Knockout of Trim61 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Trim61
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Trim61 (tripartite motif-containing 61)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. Is expressed in central nervous system; early conceptus; secondary oocyte; and testis. Orthologous to human TRIM61 (tripartite motif containing 61). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: innate immune response, regulation of gene expression; MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: Q6P242, Q8JZK6, A0A1B0GSJ5
Entrez ID: 260296
|
Does Knockout of Nek5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Nek5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nek5 (NIMA (never in mitosis gene a)-related expressed kinase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, cellular_component, cilium, motile cilium, sperm flagellum
Pathways:
UniProt: Q7TSC3
Entrez ID: 330721
|
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