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Does Knockout of Ppp2cb in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
688
Knockout
Ppp2cb
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Ppp2cb (protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic mitochondrial changes, mitotic cell cycle, negative regulation of Ras protein signal transduction, negative regulation of canonica...
Does Knockout of Smpd3 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,285
Knockout
Smpd3
cell proliferation
Mouse kidney carcinoma cell
Gene: Smpd3 (sphingomyelin phosphodiesterase 3, neutral) Type: protein-coding Summary: No summary available. Gene Ontology: BP: BMP signaling pathway, DNA biosynthetic process, G1 to G0 transition, artery smooth muscle contraction, bone development, bone growth, bone mineralization, cartilage d...
Does Knockout of Cfap45 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,278
Knockout
Cfap45
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Cfap45 (cilia and flagella associated protein 45) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cerebrospinal fluid circulation, epithelial cilium movement involved in determination of left/right asymmetry, establishment of left/right asymmetry, flagellated sperm ...
Does Knockout of C1qa in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,174
Knockout
C1qa
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: C1qa (complement component 1, q subcomponent, alpha polypeptide) Type: protein-coding Summary: No summary available. Gene Ontology: BP: astrocyte activation, complement activation, classical pathway, complement-mediated synapse pruning, immune system process, innate immune response, micro...
Does Knockout of Tpt1 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
2,403
Knockout
Tpt1
protein/peptide accumulation
Embryonic Cell Line
Gene: Tpt1 (tumor protein, translationally-controlled 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of ectoderm development, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, response to virus, spermatogenesis...
Does Knockout of Agrn in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,260
Knockout
Agrn
cell proliferation
Mouse kidney carcinoma cell
Gene: Agrn (agrin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, chemical synaptic transmission, circadian rhythm, enzyme-linked receptor protein signaling pathway, filopodium assembly, membrane organization, negative regulation of sodium ion expor...
Does Knockout of Chaf1b in Regulatory T cell causally result in cell proliferation?
0
2,127
Knockout
Chaf1b
cell proliferation
Regulatory T cell
Gene: Chaf1b (chromatin assembly factor 1, subunit B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin assembly, chromatin organization, nucleosome assembly; CC: CAF-1 complex, chromatin,...
Does Knockout of Polr3e in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,289
Knockout
Polr3e
cell proliferation
Mouse kidney carcinoma cell
Gene: Polr3e (polymerase (RNA) III (DNA directed) polypeptide E) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA-templated transcription, defense response to virus, immune system process, innate immune response; CC: DNA-directed RNA polymerase complex, RNA polymerase ...
Does Knockout of Prrx2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,266
Knockout
Prrx2
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Prrx2 (paired related homeobox 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: artery morphogenesis, cartilage development, embryonic cranial skeleton morphogenesis, embryonic limb morphogenesis, embryonic skeletal system morphogenesis, inner ear morphogenesis, m...
Does Knockout of Apip in Regulatory T cell causally result in protein/peptide accumulation?
0
1,481
Knockout
Apip
protein/peptide accumulation
Regulatory T cell
Gene: Apip (APAF1 interacting protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: L-methionine salvage from methylthioadenosine, amino acid biosynthetic process, apoptotic process, methionine biosynthetic process, negative regulation of apoptotic process, protein hom...
Does Knockout of Meioc in Lymphoma Cell Line causally result in response to chemicals?
0
1,550
Knockout
Meioc
response to chemicals
Lymphoma Cell Line
Gene: Meioc (meiosis specific with coiled-coil domain) Type: protein-coding Summary: Involved in several processes, including germ cell development; germline cell cycle switching, mitotic to meiotic cell cycle; and meiosis I. Located in cytoplasm and nucleus. Is expressed in several structures, includin...
Does Knockout of Snu13 in Colonic Cancer Cell Line causally result in cell proliferation?
0
2,179
Knockout
Snu13
cell proliferation
Colonic Cancer Cell Line
Gene: Snu13 (SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)) Type: protein-coding Summary: Enables box C/D sno(s)RNA binding activity. Involved in box C/D snoRNP assembly. Acts upstream of or within single fertilization. Part of box C/D methylation guide snoRNP complex. Is expressed in head. ...
Does Knockout of Capn3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,277
Knockout
Capn3
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Capn3 (calpain 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G1 to G0 transition involved in cell differentiation, calcium-dependent self proteolysis, cellular response to calcium ion, cellular response to salt stress, muscle structure development, myofibril as...
Does Knockout of Cma1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
0
1,077
Knockout
Cma1
protein/peptide accumulation
Mouse Embryonic Stem Cell
Gene: Cma1 (chymase 1, mast cell) Type: protein-coding Summary: This gene encodes a serine protease that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the gene...
Does Knockout of Wdr53 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,308
Knockout
Wdr53
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Wdr53 (WD repeat domain 53) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q9DB94 Entrez ID: 68980
Does Knockout of Chn1 in Melanoma Cell Line causally result in protein/peptide accumulation?
0
1,839
Knockout
Chn1
protein/peptide accumulation
Melanoma Cell Line
Gene: Chn1 (chimerin 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ephrin receptor signaling pathway, motor neuron axon guidance, nervous system development, regulation of GTPase activity, regulation of axonogenesis, regulation of small GTPase mediated signal transdu...
Does Knockout of Wfdc6a in Regulatory T cell causally result in cell proliferation?
0
2,127
Knockout
Wfdc6a
cell proliferation
Regulatory T cell
Gene: Wfdc6a (WAP four-disulfide core domain 6A) Type: protein-coding Summary: No summary available. Gene Ontology: MF: molecular_function, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space Pathways: UniP...
Does Knockout of Dnase1l1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
Dnase1l1
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Dnase1l1 (deoxyribonuclease 1-like 1) Type: protein-coding Summary: Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to huma...
Does Knockout of 1600012H06Rik in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,263
Knockout
1600012H06Rik
cell proliferation
Colonic Cancer Cell Line
Gene: 1600012H06Rik (RIKEN cDNA 1600012H06 gene) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic process, biological_process Pathways: Immune System, Innate Immune System, Neutrophil degranulation UniProt: Q9DAY5 Entrez ID: 67912
Does Knockout of Wif1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,261
Knockout
Wif1
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Wif1 (Wnt inhibitory factor 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Wnt signaling pathway, negative regulation of Wnt signaling pathway, positive regulation of fat cell differentiation; MF: Wnt-protein binding, signaling receptor binding; CC: cell surface...
Does Knockout of Arhgap15 in Mouse cell causally result in protein/peptide accumulation?
0
1,047
Knockout
Arhgap15
protein/peptide accumulation
Mouse cell
Gene: Arhgap15 (Rho GTPase activating protein 15) Type: protein-coding Summary: The protein encoded by this gene is a RAC GTPase-activating protein that is regulated through its PH domain and by recruitment to the membrane. The protein accelerates hydrolysis of guanosine triphosphate to guanosine diphos...
Does Knockout of Dram1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
Dram1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Dram1 (DNA-damage regulated autophagy modulator 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic process, autophagy, cellular response to oxygen-glucose deprivation, regulation of autophagy; CC: cytoplasm, lysosomal membrane, lysosome, membrane ...
Does Knockout of Cenpi in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,286
Knockout
Cenpi
cell proliferation
Mouse kidney carcinoma cell
Gene: Cenpi (centromere protein I) Type: protein-coding Summary: This gene encodes a protein that may be constitutively associated with centromeres and might be involved in recruiting centromere protein A to the centromere for kinetochore assembly. A similar gene in human is involved in the response of ...
Does Knockout of Gm3543 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Gm3543
phagocytosis
macrophage
Gene: Gm3543 (predicted gene 3543) Type: Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID:
Does Knockout of Hsdl2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,265
Knockout
Hsdl2
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Hsdl2 (hydroxysteroid dehydrogenase like 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: biological_process, cholesterol homeostasis; MF: molecular_function, oxidoreductase activity; CC: mitochondrion, peroxisome Pathways: UniProt: Q2TPA8 ...
Does Knockout of Ptbp3 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
2,403
Knockout
Ptbp3
protein/peptide accumulation
Embryonic Cell Line
Gene: Ptbp3 (polypyrimidine tract binding protein 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA splicing, cell differentiation, erythrocyte maturation, mRNA processing, negative regulation of RNA splicing, negative regulation of mRNA splicing, via spliceosome, re...
Does Knockout of Ccnd1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
1
1,565
Knockout
Ccnd1
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Ccnd1 (cyclin D1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, G1/S transition of mitotic cell cycle, Leydig cell differentiation, Wnt signaling pathway, animal organ regeneration, cell division, cell population proliferation, cellular respon...
Does Knockout of Mcm8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,277
Knockout
Mcm8
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Mcm8 (minichromosome maintenance 8 homologous recombination repair factor) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, double-strand break repair via homologous recombination, female gamete generation, male gamet...
Does Knockout of Polg2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
163
Knockout
Polg2
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Polg2 (polymerase (DNA directed), gamma 2, accessory subunit) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA biosynthetic process, DNA repair, DNA replication, DNA-templated DNA replication, in utero embryonic development, mitochondrial DNA metabolic process, m...
Does Knockout of Zfp790 in Melanoma Cell Line causally result in cell proliferation?
0
1,838
Knockout
Zfp790
cell proliferation
Melanoma Cell Line
Gene: Zfp790 (zinc finger protein 790) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA ...
Does Knockout of Aggf1 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,481
Knockout
Aggf1
protein/peptide accumulation
Regulatory T cell
Gene: Aggf1 (angiogenic factor with G patch and FHA domains 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: angiogenesis, cell adhesion, cell differentiation, positive regulation of angiogenesis, positive regulation of endothelial cell proliferation; MF: identical prot...
Does Knockout of Adora3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
1,130
Knockout
Adora3
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Adora3 (adenosine A3 receptor) Type: protein-coding Summary: This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by ...
Does Knockout of Neurod6 in Pancreatic Cell Line causally result in protein/peptide accumulation?
0
2,195
Knockout
Neurod6
protein/peptide accumulation
Pancreatic Cell Line
Gene: Neurod6 (neurogenic differentiation 6) Type: protein-coding Summary: No summary available. Gene Ontology: BP: axon development, cell differentiation, central nervous system development, dentate gyrus development, nervous system development, positive regulation of transcription by RNA poly...
Does Knockout of Atf5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,280
Knockout
Atf5
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Atf5 (activating transcription factor 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cerebellar granule cell precursor proliferation, circadian rhythm, fat cell differentiation, multicellular organism growth, negative regulation of DNA-templated transcription, n...
Does Knockout of Cttnbp2 in Mouse cell causally result in protein/peptide accumulation?
0
1,047
Knockout
Cttnbp2
protein/peptide accumulation
Mouse cell
Gene: Cttnbp2 (cortactin binding protein 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of modification of postsynaptic actin cytoskeleton, regulation of synapse organization; MF: SH3 domain binding, protein binding; CC: FAR/SIN/STRIPAK complex, cell cortex...
Does Knockout of Gdap2 in breast epithelium causally result in cell cycle progression?
0
1,470
Knockout
Gdap2
cell cycle progression
breast epithelium
Gene: Gdap2 (ganglioside-induced differentiation-associated-protein 2) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q9DBL2 Entrez ID: 14547
Does Knockout of Ndel1 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,399
Knockout
Ndel1
protein/peptide accumulation
Microglial Cell Line
Gene: Ndel1 (nudE neurodevelopment protein 1 like 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: canonical Wnt signaling pathway, cell differentiation, cell migration, central nervous system neuron axonogenesis, centrosome localization, cerebral cortex radially orient...
Does Knockout of Ankrd13d in Neuroblastoma Cell Line causally result in response to virus?
0
1,422
Knockout
Ankrd13d
response to virus
Neuroblastoma Cell Line
Gene: Ankrd13d (ankyrin repeat domain 13 family, member D) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of receptor internalization; MF: ubiquitin-modified protein reader activity; CC: cytoplasm, endosome, late endosome, membrane, perinuclear region...
Does Knockout of Arpc3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,174
Knockout
Arpc3
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Arpc3 (actin related protein 2/3 complex, subunit 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, regulation of actin filament polymerization, regulation of synaptic vesicle endocytosis; MF: actin binding, actin filament ...
Does Knockout of Abcb4 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,172
Knockout
Abcb4
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Abcb4 (ATP-binding cassette, sub-family B member 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: bile acid secretion, cellular response to bile acid, lipid homeostasis, lipid transport, phospholipid translocation, positive regulation of cholesterol transport, pos...
Does Knockout of Atp2a2 in Regulatory T cell causally result in protein/peptide accumulation?
1
1,481
Knockout
Atp2a2
protein/peptide accumulation
Regulatory T cell
Gene: Atp2a2 (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ER-nucleus signaling pathway, T-tubule organization, autophagosome assembly, autophagosome membrane docking, calcium ion import into sarcoplasmic reticu...
Does Knockout of Efhd2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,308
Knockout
Efhd2
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Efhd2 (EF hand domain containing 2) Type: protein-coding Summary: Enables calcium ion binding activity. Predicted to be located in membrane raft. Is expressed in brain; embryo endoderm; extraembryonic component; gut; and heart. Orthologous to human EFHD2 (EF-hand domain family member D2). [provide...
Does Knockout of A630073D07Rik in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
A630073D07Rik
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: A630073D07Rik (RIKEN cDNA A630073D07 gene) Type: protein-coding Summary: RIKEN cDNA A630073D07 gene Gene Ontology: CC: cellular_component, extracellular region Pathways: UniProt: E9PWS6 Entrez ID: 381819
Does Knockout of Tmem161b in Pancreatic Cancer Cell Line causally result in response to chemicals?
0
2,359
Knockout
Tmem161b
response to chemicals
Pancreatic Cancer Cell Line
Gene: Tmem161b (transmembrane protein 161B) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of cardiac muscle cell action potential, regulation of heart rate; CC: cellular_component, membrane, plasma membrane Pathways: UniProt: Q8C2L6 ...
Does Knockout of Rhobtb2 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Rhobtb2
protein/peptide accumulation
Embryonic Cell Line
Gene: Rhobtb2 (Rho-related BTB domain containing 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: actin filament organization, cortical cytoskeleton organization, establishment or maintenance of cell polarity, protein ubiquitination, regulation of actin cytoskeleton org...
Does Knockout of Togaram2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,272
Knockout
Togaram2
cell proliferation
Mouse kidney carcinoma cell
Gene: Togaram2 (TOG array regulator of axonemal microtubules 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: microtubule cytoskeleton organization, negative regulation of cytoskeleton organization, negative regulation of supramolecular fiber organization; MF: microtubu...
Does Knockout of Cnppd1 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
2,403
Knockout
Cnppd1
protein/peptide accumulation
Embryonic Cell Line
Gene: Cnppd1 (cyclin Pas1/PHO80 domain containing 1) Type: protein-coding Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be located in membrane. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be act...
Does Knockout of Hhatl in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,264
Knockout
Hhatl
cell proliferation
Colonic Cancer Cell Line
Gene: Hhatl (hedgehog acyltransferase-like) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of N-terminal protein palmitoylation, regulation of protein modification process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, perinucle...
Does Knockout of Cpz in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Cpz
cell cycle progression
breast epithelium
Gene: Cpz (carboxypeptidase Z) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Wnt signaling pathway, peptide metabolic process, protein processing, proteolysis; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metall...
Does Knockout of Tshz2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,285
Knockout
Tshz2
cell proliferation
Mouse kidney carcinoma cell
Gene: Tshz2 (teashirt zinc finger family member 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, meta...
Does Knockout of Ddit3 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,152
Knockout
Ddit3
protein/peptide accumulation
Embryonic Cell Line
Gene: Ddit3 (DNA-damage inducible transcript 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ER overload response, GDF15-GFRAL signaling pathway, HRI-mediated signaling, Wnt signaling pathway, anterior/posterior axis specification, apoptotic process, artery development...
Does Knockout of Lpar4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
167
Knockout
Lpar4
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Lpar4 (lysophosphatidic acid receptor 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, lipid binding, lysophosphatidic acid binding, lysophosphatidic acid r...
Does Knockout of Tbp in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
688
Knockout
Tbp
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Tbp (TATA box binding protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase I preinitiation complex assembly, RNA polymerase II preinitiation complex assembly, mRNA transcription by RNA polymerase II, positiv...
Does Knockout of Defb43 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,259
Knockout
Defb43
cell proliferation
Mouse kidney carcinoma cell
Gene: Defb43 (defensin beta 43) Type: protein-coding Summary: No summary available. Gene Ontology: BP: defense response, defense response to bacterium, innate immune response; CC: extracellular region, extracellular space Pathways: Antimicrobial peptides, Beta defensins, Defensins, Imm...
Does Knockout of Ubr1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,174
Knockout
Ubr1
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Ubr1 (ubiquitin protein ligase E3 component n-recognin 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular response to L-leucine, negative regulation of TOR signaling, proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic proce...
Does Knockout of Itih5 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,289
Knockout
Itih5
cell proliferation
Mouse kidney carcinoma cell
Gene: Itih5 (inter-alpha-trypsin inhibitor, heavy chain 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: biological_process, hyaluronan metabolic process, uterus development; MF: molecular_function, peptidase inhibitor activity, serine-type endopeptidase inhibitor activ...
Does Knockout of Rnf122 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
2,403
Knockout
Rnf122
protein/peptide accumulation
Embryonic Cell Line
Gene: Rnf122 (ring finger protein 122) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of mitochondrial membrane potential, positive regulation of apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autoubiquit...
Does Knockout of Ttpa in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
Ttpa
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Ttpa (tocopherol (alpha) transfer protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: embryonic placenta development, intermembrane lipid transfer, intracellular pH reduction, negative regulation of epithelial cell apoptotic process, negative regulation of esta...
Does Knockout of Tstd2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,278
Knockout
Tstd2
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Tstd2 (thiosulfate sulfurtransferase (rhodanese)-like domain containing 2) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q3U269 Entrez ID: 272027
Does Knockout of Mlf2 in myoblast cell line causally result in protein/peptide distribution?
0
1,680
Knockout
Mlf2
protein/peptide distribution
myoblast cell line
Gene: Mlf2 (myeloid leukemia factor 2) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cytoplasm, glutamatergic synapse, nucleus, synapse Pathways: UniProt: Q99KX1 Entrez ID: 30853
Does Knockout of Tat in breast epithelium causally result in cell cycle progression?
0
1,469
Knockout
Tat
cell cycle progression
breast epithelium
Gene: Tat (tyrosine aminotransferase) Type: protein-coding Summary: This gene encodes a liver-specific mitochondrial enzyme that catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Regulated by glucocorticoid and polypeptide hormones, this gene's expression is affected by deletion of a ...
Does Knockout of Cst13 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,285
Knockout
Cst13
cell proliferation
Mouse kidney carcinoma cell
Gene: Cst13 (cystatin 13) Type: protein-coding Summary: No summary available. Gene Ontology: MF: cysteine-type endopeptidase inhibitor activity, peptidase inhibitor activity; CC: cytoplasm, extracellular region Pathways: UniProt: Q80ZN5 Entrez ID: 69294
Does Knockout of Fam3a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
82
Knockout
Fam3a
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Fam3a (FAM3 metabolism regulating signaling molecule A) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ATP biosynthetic process, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, calcium ion homeostasis, gene expr...
Does Knockout of Gltp in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,263
Knockout
Gltp
cell proliferation
Colonic Cancer Cell Line
Gene: Gltp (glycolipid transfer protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ceramide 1-phosphate transport, ceramide transport, intermembrane lipid transfer, lipid transport, response to immobilization stress; MF: ceramide 1-phosphate binding, ceramide 1-phos...
Does Knockout of Calcoco2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
688
Knockout
Calcoco2
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Calcoco2 (calcium binding and coiled-coil domain 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: autophagy, positive regulation of autophagosome maturation, response to type II interferon, xenophagy; CC: PML body, autophagosome, autophagosome membrane, cytoplasm,...
Does Knockout of Gdf15 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,286
Knockout
Gdf15
cell proliferation
Mouse kidney carcinoma cell
Gene: Gdf15 (growth differentiation factor 15) Type: protein-coding Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcri...
Does Knockout of Slc36a2 in Melanoma Cell Line causally result in protein/peptide accumulation?
0
1,839
Knockout
Slc36a2
protein/peptide accumulation
Melanoma Cell Line
Gene: Slc36a2 (solute carrier family 36 (proton/amino acid symporter), member 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: L-alanine transport, amino acid export across plasma membrane, glycine transport, positive regulation of glycine import across plasma membrane,...
Does Knockout of Inca1 in pro-B-lymphocyte causally result in response to chemicals?
0
1,720
Knockout
Inca1
response to chemicals
pro-B-lymphocyte
Gene: Inca1 (inhibitor of CDK, cyclin A1 interacting protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic signaling pathway, negative regulation of cell population proliferation, negative regulation of fibroblast proliferation, positive regulation of apopt...
Does Knockout of Cldn11 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
83
Knockout
Cldn11
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Cldn11 (claudin 11) Type: protein-coding Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the para...
Does Knockout of 4930522H14Rik in Pancreatic Cancer Cell Line causally result in response to chemicals?
0
2,359
Knockout
4930522H14Rik
response to chemicals
Pancreatic Cancer Cell Line
Gene: 4930522H14Rik (RIKEN cDNA 4930522H14 gene) Type: protein-coding Summary: Predicted to be located in membrane. Orthologous to human C1orf185 (chromosome 1 open reading frame 185). [provided by Alliance of Genome Resources, Jul 2025] Gene Ontology: CC: cellular_component, membrane ...
Does Knockout of Cts3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,279
Knockout
Cts3
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Cts3 (cathepsin 3) Type: protein-coding Summary: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in extraembryonic component; head; laby...
Does Knockout of Plat in Colonic Cancer Cell Line causally result in tumorigenicity?
0
2,177
Knockout
Plat
tumorigenicity
Colonic Cancer Cell Line
Gene: Plat (plasminogen activator, tissue) Type: protein-coding Summary: This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a pr...
Does Knockout of Prop1 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,399
Knockout
Prop1
protein/peptide accumulation
Microglial Cell Line
Gene: Prop1 (paired like homeodomain factor 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: adenohypophysis development, animal organ morphogenesis, blood vessel development, cell migration, dorsal/ventral pattern formation, gland development, hypophysis morphogenesis,...
Does Knockout of Lrrc51 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
163
Knockout
Lrrc51
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Lrrc51 (leucine rich repeat containing 51) Type: protein-coding Summary: Predicted to be located in cytoplasm. Predicted to be active in axoneme. Is expressed in brain; gut gland; nasal cavity respiratory epithelium; respiratory system; and testis. Human ortholog(s) of this gene implicated in auto...
Does Knockout of Usp49 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,265
Knockout
Usp49
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Usp49 (ubiquitin specific peptidase 49) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA splicing, chromatin organization, chromatin remodeling, mRNA processing, mRNA splicing, via spliceosome, negative regulation of phosphatidylinositol 3-kinase/protein kinase B...
Does Knockout of Ube2h in macrophage causally result in phagocytosis?
0
1,890
Knockout
Ube2h
phagocytosis
macrophage
Gene: Ube2h (ubiquitin-conjugating enzyme E2H) Type: protein-coding Summary: No summary available. Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein polyubiquitination, protein ubiq...
Does Knockout of Tm6sf2 in Melanoma Cell Line causally result in cell proliferation?
0
1,838
Knockout
Tm6sf2
cell proliferation
Melanoma Cell Line
Gene: Tm6sf2 (transmembrane 6 superfamily member 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: lipid homeostasis, regulation of lipid metabolic process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment me...
Does Knockout of Nek4 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,175
Knockout
Nek4
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Nek4 (NIMA (never in mitosis gene a)-related expressed kinase 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, cell division, mitotic cell cycle, positive regulation of DNA-templated transcription, protein phosphorylation, regulation of cellul...
Does Knockout of Klhl20 in Melanoma Cell Line causally result in cell proliferation?
0
1,270
Knockout
Klhl20
cell proliferation
Melanoma Cell Line
Gene: Klhl20 (kelch-like 20) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Golgi to endosome transport, negative regulation of apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K33-linked ubiquitination, protein transport, pro...
Does Knockout of Smim13 in Embryonic Fibroblast Cell Line causally result in response to virus?
0
1,133
Knockout
Smim13
response to virus
Embryonic Fibroblast Cell Line
Gene: Smim13 (small integral membrane protein 13) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cellular_component, membrane Pathways: UniProt: E9Q942 Entrez ID: 108934
Does Knockout of Abcf3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,279
Knockout
Abcf3
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Abcf3 (ATP-binding cassette, sub-family F member 3) Type: protein-coding Summary: No summary available. Gene Ontology: MF: ATP binding, ATP hydrolysis activity, nucleotide binding, protein binding Pathways: UniProt: Q8K268 Entrez ID: 27406
Does Knockout of Vmn2r9 in Melanoma Cell Line causally result in cell proliferation?
0
2,492
Knockout
Vmn2r9
cell proliferation
Melanoma Cell Line
Gene: Vmn2r9 (vomeronasal 2, receptor 9) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane Pathways: UniProt: A0A3B2W...
Does Knockout of Qsox2 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,276
Knockout
Qsox2
cell proliferation
Colonic Cancer Cell Line
Gene: Qsox2 (quiescin Q6 sulfhydryl oxidase 2) Type: protein-coding Summary: This gene encodes a member of the sulfhydryl oxidase protein family. Members of this family catalyze formation of disulfide bonds. A similar protein in humans may sensitize neuroblastoma cells to interferon gamma-induced cell d...
Does Knockout of Ppdpf in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,267
Knockout
Ppdpf
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Ppdpf (pancreatic progenitor cell differentiation and proliferation factor) Type: protein-coding Summary: No summary available. Gene Ontology: BP: TOR signaling, TORC1 signaling, cell differentiation, liver development Pathways: UniProt: Q9CR37 Entrez ID: 66496
Does Knockout of Tmem62 in myoblast cell line causally result in protein/peptide distribution?
0
1,682
Knockout
Tmem62
protein/peptide distribution
myoblast cell line
Gene: Tmem62 (transmembrane protein 62) Type: protein-coding Summary: No summary available. Gene Ontology: MF: hydrolase activity, molecular_function; CC: cellular_component, membrane Pathways: UniProt: Q8BXJ9 Entrez ID: 96957
Does Knockout of Icam5 in Embryonic Stem Cell Line causally result in cell proliferation?
0
578
Knockout
Icam5
cell proliferation
Embryonic Stem Cell Line
Gene: Icam5 (intercellular adhesion molecule 5, telencephalin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell adhesion, cell-cell adhesion, phagocytosis, regulation of synapse assembly; MF: integrin binding, protein binding; CC: glutamatergic synapse, membrane, plas...
Does Knockout of Ino80 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
1
2,411
Knockout
Ino80
cell proliferation
Cytotoxic T-lymphocyte (CD8+ T cells)
Gene: Ino80 (INO80 complex subunit) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA recombination, DNA repair, DNA-templated transcription, UV-damage excision repair, cell division, cellular response to UV, cellular response...
Does Knockout of Gm15103 in Microglial Cell Line causally result in cell proliferation?
0
1,358
Knockout
Gm15103
cell proliferation
Microglial Cell Line
Gene: Gm15103 (ovary testis transcribed pseudogene) Type: pseudo Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID: 100039669
Does Knockout of Trim24 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
82
Knockout
Trim24
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Trim24 (tripartite motif-containing 24) Type: protein-coding Summary: The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC f...
Does Knockout of Nt5e in Embryonic Cell Line causally result in protein/peptide accumulation?
0
2,403
Knockout
Nt5e
protein/peptide accumulation
Embryonic Cell Line
Gene: Nt5e (5' nucleotidase, ecto) Type: protein-coding Summary: This gene encodes a membrane-bound nucleotidase that hydrolyzes extracellular nucleoside monophosphates. The encoded preproprotein undergoes proteolytic processing to generate to a functional, homodimeric enzyme that preferentially uses ad...
Does Knockout of Gm5544 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
84
Knockout
Gm5544
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Gm5544 (predicted gene 5544) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q3UQK6 Entrez ID: 433632
Does Knockout of Lrch1 in macrophage causally result in response to bacteria?
0
2,211
Knockout
Lrch1
response to bacteria
macrophage
Gene: Lrch1 (leucine-rich repeats and calponin homology (CH) domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular response to chemokine, negative regulation of GTPase activity, negative regulation of T cell migration; CC: cytoplasm Pathwa...
Does Knockout of Sh3bp5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
163
Knockout
Sh3bp5
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Sh3bp5 (SH3-domain binding protein 5 (BTK-associated)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: intracellular signal transduction, negative regulation of protein kinase activity; MF: SH3 domain binding, guanyl-nucleotide exchange factor activity, protein kina...
Does Knockout of Slc7a11 in Melanoma Cell Line causally result in cell proliferation?
0
2,488
Knockout
Slc7a11
cell proliferation
Melanoma Cell Line
Gene: Slc7a11 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 11) Type: protein-coding Summary: No summary available. Gene Ontology: BP: L-cystine transport, L-glutamate import across plasma membrane, L-glutamate transmembrane transport, L-kynurenine transmembrane ...
Does Knockout of Mup20 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Mup20
phagocytosis
macrophage
Gene: Mup20 (major urinary protein 20) Type: protein-coding Summary: No summary available. Gene Ontology: BP: olfactory learning, positive regulation of neural precursor cell proliferation, positive regulation of neurogenesis, signal transduction, vocalization behavior; MF: mating pheromone act...
Does Knockout of Dhx34 in myoblast cell line causally result in protein/peptide distribution?
0
1,681
Knockout
Dhx34
protein/peptide distribution
myoblast cell line
Gene: Dhx34 (DExH-box helicase 34) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-...
Does Knockout of Awat2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,283
Knockout
Awat2
cell proliferation
Mouse kidney carcinoma cell
Gene: Awat2 (acyl-CoA wax alcohol acyltransferase 2) Type: protein-coding Summary: Enables retinol O-fatty-acyltransferase activity. Acts upstream of or within wax biosynthetic process. Located in endoplasmic reticulum membrane. Used to study dry eye syndrome. Orthologous to human AWAT2 (acyl-CoA wax al...
Does Knockout of Prr18 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,278
Knockout
Prr18
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Prr18 (proline rich 18) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q6PAN7 Entrez ID: 320111
Does Knockout of Trim61 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
161
Knockout
Trim61
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Trim61 (tripartite motif-containing 61) Type: protein-coding Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. Is expressed in central nervous system; early conc...
Does Knockout of Nek5 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,290
Knockout
Nek5
cell proliferation
Mouse kidney carcinoma cell
Gene: Nek5 (NIMA (never in mitosis gene a)-related expressed kinase 5) Type: protein-coding Summary: No summary available. Gene Ontology: MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine ki...