prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Prss3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Prss3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Prss3 (serine protease 3)
Type: protein-coding
Summary: Enables serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS1 (serine protease 1) and PRSS2 (serine protease 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: proteolysis; MF: calcium ion binding, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Activation of Matrix Metalloproteinases, Alpha-defensins, Antimicrobial peptides, Defensins, Degradation of the extracellular matrix, Extracellular matrix organization, Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neutrophil degranulation, Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q792Z0
Entrez ID: 22073
|
Does Knockout of Tsc1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Tsc1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tsc1 (TSC complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import, TORC1 signaling, adaptive immune response, adult locomotory behavior, associative learning, cardiac muscle cell differentiation, cell projection organization, cell-matrix adhesion, cellular response to decreased oxygen levels, cellular response to starvation, cerebral cortex development, hippocampus development, kidney development, memory T cell differentiation, myelination, negative regulation of ATP-dependent activity, negative regulation of TOR signaling, negative regulation of TORC1 signaling, negative regulation of cell population proliferation, negative regulation of cell size, negative regulation of cellular response to oxidative stress, negative regulation of macroautophagy, negative regulation of neuron projection development, nervous system development, neural tube closure, positive regulation of TORC1 signaling, positive regulation of focal adhesion assembly, positive regulation of macroautophagy, positive regulation of stress fiber assembly, potassium ion transport, protein folding, protein stabilization, regulation of cell cycle, regulation of cell-matrix adhesion, regulation of focal adhesion assembly, regulation of stress fiber assembly, response to insulin, synapse organization; MF: ATPase inhibitor activity, Hsp70 protein binding, Hsp90 protein binding, protein binding, protein folding chaperone, protein-folding chaperone binding; CC: TSC1-TSC2 complex, actin filament, cell cortex, cell projection, ciliary basal body, cytoplasm, cytosol, growth cone, lamellipodium, lipid droplet, lysosomal membrane, lysosome, membrane, nucleus, perinuclear region of cytoplasm, postsynaptic density, protein folding chaperone complex, protein-containing complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Inhibition of TSC complex formation by PKB, Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), MTOR signalling, Macroautophagy, Membrane Trafficking, PI3K-Akt signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Rab regulation of trafficking, Signal Transduction, TBC/RABGAPs, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, Vesicle-mediated transport, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9EP53
Entrez ID: 64930
|
Does Knockout of Ptpn7 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Ptpn7
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ptpn7 (protein tyrosine phosphatase, non-receptor type 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity; CC: cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, microtubule cytoskeleton, mitotic spindle
Pathways: MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, RAF/MAP kinase cascade, Signal Transduction
UniProt: Q8BUM3
Entrez ID: 320139
|
Does Knockout of Vezf1 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Vezf1
|
response to bacteria
|
macrophage
|
Gene: Vezf1 (vascular endothelial zinc finger 1)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within angiogenesis and endothelial cell development. Located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and liver. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human VEZF1 (vascular endothelial zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: angiogenesis, endothelial cell development, positive regulation of DNA-templated transcription, positive regulation of endothelial cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q5SXC3, Q5SXC4
Entrez ID: 22344
|
Does Knockout of Dll4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,683
|
Knockout
|
Dll4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dll4 (delta like canonical Notch ligand 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, T cell differentiation, angiogenesis, animal organ development, aortic valve morphogenesis, blood vessel lumenization, blood vessel remodeling, branching involved in blood vessel morphogenesis, cardiac atrium morphogenesis, cardiac ventricle morphogenesis, cell communication, cell differentiation, cellular response to fibroblast growth factor stimulus, cellular response to vascular endothelial growth factor stimulus, dorsal aorta morphogenesis, endothelium development, morphogenesis of an epithelium, negative regulation of Notch signaling pathway, negative regulation of blood vessel endothelial cell migration, negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of cell population proliferation, negative regulation of endothelial cell migration, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, nervous system development, pericardium morphogenesis, positive regulation of Notch signaling pathway, positive regulation of gene expression, positive regulation of neural precursor cell proliferation, regulation of neural retina development, regulation of neurogenesis, system development, ventral spinal cord interneuron fate commitment, ventricular trabecula myocardium morphogenesis, visual perception; MF: Notch binding, calcium ion binding, protein binding, receptor ligand activity; CC: membrane, plasma membrane
Pathways: Breast cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, Notch signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signal Transduction, Signaling by NOTCH, Signaling by NOTCH2, Signaling by NOTCH3, Th1 and Th2 cell differentiation - Mus musculus (mouse)
UniProt: Q9JI71
Entrez ID: 54485
|
Does Knockout of Ushbp1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Ushbp1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ushbp1 (USH1 protein network component harmonin binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: PDZ domain binding
Pathways:
UniProt: Q8R370
Entrez ID: 234395
|
Does Knockout of Usp30 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Usp30
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Usp30 (ubiquitin specific peptidase 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy of mitochondrion, mitochondrial fusion, negative regulation of mitophagy, protein K11-linked deubiquitination, protein K6-linked deubiquitination, protein deubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding; CC: cytosol, membrane, mitochondrial outer membrane, mitochondrion, nucleus
Pathways: Autophagy, Deubiquitination, Macroautophagy, Metabolism of proteins, Mitophagy - animal - Mus musculus (mouse), Pexophagy, Post-translational protein modification, Selective autophagy, Ub-specific processing proteases
UniProt: Q3UN04
Entrez ID: 100756
|
Does Knockout of B4galt6 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
B4galt6
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: B4galt6 (UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, central nervous system myelination, central nervous system neuron axonogenesis, ganglioside biosynthetic process via lactosylceramide, glycosphingolipid biosynthetic process, glycosylation, lactosylceramide biosynthetic process, lipid metabolic process, neuron maturation, protein glycosylation, sphingolipid biosynthetic process, sphingolipid metabolic process; MF: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity, galactosyltransferase activity, glycosyltransferase activity, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane
Pathways: Asparagine N-linked glycosylation, Glycosaminoglycan metabolism, Glycosphingolipid biosynthesis, Glycosphingolipid metabolism, Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of lipids, Metabolism of proteins, N-Glycan antennae elongation, N-glycan antennae elongation in the medial/trans-Golgi, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Transport to the Golgi and subsequent modification
UniProt: Q9WVK5
Entrez ID: 56386
|
Does Knockout of Rgs2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Rgs2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rgs2 (regulator of G-protein signaling 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, brown fat cell differentiation, maternal process involved in female pregnancy, negative regulation of G protein-coupled receptor signaling pathway, negative regulation of JNK cascade, negative regulation of cardiac muscle hypertrophy, negative regulation of cell growth involved in cardiac muscle cell development, negative regulation of glycine import across plasma membrane, negative regulation of signal transduction, negative regulation of translation, positive regulation of cardiac muscle contraction, positive regulation of neuron projection development, positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway, regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway, regulation of translation, relaxation of cardiac muscle, relaxation of vascular associated smooth muscle, response to amphetamine, response to ethanol, spermatogenesis; MF: G-protein alpha-subunit binding, GTPase activator activity, adenylate cyclase inhibitor activity, beta-tubulin binding, protein binding; CC: cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane, nucleolus, nucleus, plasma membrane
Pathways: G alpha (q) signalling events, GPCR downstream signalling, Olfactory transduction - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: O08849
Entrez ID: 19735
|
Does Knockout of Fcho2 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Fcho2
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Fcho2 (FCH domain only 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: clathrin coat assembly, clathrin-dependent endocytosis, endocytosis, membrane invagination, protein localization to plasma membrane, synaptic vesicle endocytosis; MF: identical protein binding, phosphatidylinositol binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylserine binding, protein binding; CC: clathrin-coated pit, clathrin-coated vesicle, cytoplasm, membrane, plasma membrane, presynapse, synapse
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q3UQN2
Entrez ID: 218503
|
Does Knockout of Natd1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Natd1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Natd1 (N-acetyltransferase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DBW3
Entrez ID: 24083
|
Does Knockout of Kremen1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Kremen1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kremen1 (kringle containing transmembrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, apoptotic process, limb development, negative regulation of axon regeneration, negative regulation of canonical Wnt signaling pathway, negative regulation of ossification, signal transduction; CC: membrane, neuronal cell body, plasma membrane
Pathways: Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q99N43
Entrez ID: 84035
|
Does Knockout of Phkg2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Phkg2
|
response to virus
|
Microglial Cell Line
|
Gene: Phkg2 (phosphorylase kinase, gamma 2 (testis))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycogen catabolic process, glycogen metabolic process, positive regulation of glycogen catabolic process, signal transduction; MF: ATP binding, calmodulin binding, enzyme binding, kinase activity, nucleotide binding, phosphorylase kinase activity, protein kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, phosphorylase kinase complex
Pathways: Calcium signaling pathway - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glycogen breakdown (glycogenolysis), Glycogen metabolism, Insulin signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q9DB30
Entrez ID: 68961
|
Does Knockout of Cntrob in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Cntrob
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cntrob (centrobin, centrosomal BRCA2 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centriole replication, centrosome separation, mitotic cytokinetic process, regulation of cilium assembly; MF: protein domain specific binding; CC: centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol
Pathways:
UniProt: Q8CB62
Entrez ID: 216846
|
Does Knockout of Ccdc170 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Ccdc170
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Ccdc170 (coiled-coil domain containing 170)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization; MF: microtubule binding; CC: Golgi apparatus, cell junction, ciliary basal body
Pathways:
UniProt: F6ST92, D3YXL0, D3Z4M1
Entrez ID: 100504234
|
Does Knockout of Cetn2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Cetn2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cetn2 (centrin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cell division, centriole replication, mRNA transport, microtubule cytoskeleton organization, nucleotide-excision repair, protein transport, regulation of cytokinesis, spermatogenesis; MF: G-protein beta/gamma-subunit complex binding, calcium ion binding, heterotrimeric G-protein binding, metal ion binding, microtubule binding; CC: 9+2 motile cilium, XPC complex, apical part of cell, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, glial cell projection, microtubule organizing center, nuclear envelope, nuclear pore, nuclear pore nuclear basket, nucleus, photoreceptor connecting cilium, transcription export complex 2
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, DNA Damage Recognition in GG-NER, DNA Repair, Formation of Incision Complex in GG-NER, G2/M Transition, Global Genome Nucleotide Excision Repair (GG-NER), Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Organelle biogenesis and maintenance, Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q9R1K9
Entrez ID: 26370
|
Does Knockout of Trmt44 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Trmt44
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Trmt44 (tRNA methyltransferase 44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, tRNA methylation, tRNA processing; MF: metal ion binding, methyltransferase activity, tRNA (uridine) methyltransferase activity, tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity, transferase activity, zinc ion binding; CC: cellular_component, cytoplasm
Pathways:
UniProt: Q9D2Q2
Entrez ID: 78890
|
Does Knockout of Mfap4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Mfap4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mfap4 (microfibrillar-associated protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UV protection, cell adhesion, cellular response to UV-B, elastic fiber assembly, regulation of collagen metabolic process, supramolecular fiber organization; CC: elastic fiber, extracellular matrix, extracellular region, extracellular space, microfibril
Pathways: Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres
UniProt: Q9D1H9
Entrez ID: 76293
|
Does Knockout of Set in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Set
|
cell proliferation
|
Regulatory T cell
|
Gene: Set (SET nuclear oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of neuron apoptotic process, nucleosome assembly; MF: DNA binding, chromatin binding, histone binding; CC: chromatin, cytoplasm, cytosol, endoplasmic reticulum, lipid droplet, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Condensation of Prophase Chromosomes, HuR (ELAVL1) binds and stabilizes mRNA, M Phase, Metabolism of RNA, Mitotic Prophase, Regulation of mRNA stability by proteins that bind AU-rich elements
UniProt: Q9EQU5
Entrez ID: 56086
|
Does Knockout of Plscr3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Plscr3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Plscr3 (phospholipid scramblase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to lipopolysaccharide, cholesterol homeostasis, glucose homeostasis, lipid transport, mitochondrial membrane organization, plasma membrane phospholipid scrambling, regulation of apoptotic process, regulation of release of cytochrome c from mitochondria; MF: SH3 domain binding, calcium ion binding, calcium-dependent protein binding, lead ion binding, magnesium ion binding, mercury ion binding, phospholipid scramblase activity; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleus, plasma membrane
Pathways:
UniProt: Q9JIZ9
Entrez ID: 70310
|
Does Knockout of Fbxo10 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Fbxo10
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fbxo10 (F-box protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, protein ubiquitination, regulation of apoptotic process, ubiquitin-dependent protein catabolic process; CC: cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q7TQF2
Entrez ID: 269529
|
Does Knockout of Smarcd3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Smarcd3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Smarcd3 (SWI/SNF related BAF chromatin remodeling complex subunit D3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac right ventricle formation, chromatin organization, chromatin remodeling, heart morphogenesis, muscle cell differentiation, nervous system development, neural retina development, nucleosome disassembly, positive regulation of DNA-templated transcription, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of neuroblast proliferation, positive regulation of smooth muscle cell differentiation, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, secondary heart field specification; MF: DNA-binding transcription factor binding, chromatin binding, nuclear receptor binding, protein binding, signaling receptor binding, transcription coactivator activity, transcription coregulator activity, transcription coregulator binding; CC: SWI/SNF complex, brahma complex, chromatin, cytoplasm, nBAF complex, npBAF complex, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Cytoprotection by HMOX1, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of lipids, RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Regulation of lipid metabolism by PPARalpha, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: Q6P9Z1
Entrez ID: 66993
|
Does Knockout of Elavl1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Elavl1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Elavl1 (ELAV like RNA binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, cell population proliferation, lncRNA-mediated post-transcriptional gene silencing, mRNA destabilization, mRNA stabilization, negative regulation of miRNA-mediated gene silencing, positive regulation of autophagosome size, positive regulation of autophagy, positive regulation of superoxide anion generation, positive regulation of translation, post-transcriptional gene silencing, protein homooligomerization, protein import into nucleus, regulation of mRNA stability, regulation of stem cell population maintenance, response to glucose; MF: RNA binding, double-stranded RNA binding, lncRNA binding, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, mRNA binding, miRNA binding, nucleic acid binding, protein binding, protein homodimerization activity, protein kinase binding; CC: P-body, cytoplasm, cytoplasmic stress granule, cytoplasmic vesicle, cytosol, endoplasmic reticulum, glutamatergic synapse, nucleoplasm, nucleus, postsynapse, ribonucleoprotein complex, sarcoplasm
Pathways: AMPK signaling pathway - Mus musculus (mouse), HuR (ELAVL1) binds and stabilizes mRNA, IL-17 signaling pathway - Mus musculus (mouse), Metabolism of RNA, Regulation of mRNA stability by proteins that bind AU-rich elements
UniProt: P70372
Entrez ID: 15568
|
Does Knockout of Cyp2d12 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Cyp2d12
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cyp2d12 (cytochrome P450, family 2, subfamily d, polypeptide 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, xenobiotic metabolic process; MF: anandamide 11,12 epoxidase activity, anandamide 14,15 epoxidase activity, anandamide 8,9 epoxidase activity, aromatase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, mitochondrion
Pathways: Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse)
UniProt: Q8BVD2, B7ZP10, A0A2R8VHA2, A0A2R8VJY6
Entrez ID: 380997
|
Does Knockout of Palb2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Palb2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Palb2 (partner and localizer of BRCA2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, animal organ morphogenesis, double-strand break repair via homologous recombination, embryonic organ development, in utero embryonic development, inner cell mass cell proliferation, mesoderm development, multicellular organism growth, negative regulation of apoptotic process, post-anal tail morphogenesis, somitogenesis; MF: DNA binding; CC: DNA repair complex, nuclear speck, nucleoplasm, nucleus, protein-containing complex
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q3U0P1
Entrez ID: 233826
|
Does Knockout of Phf10 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Phf10
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Phf10 (PHD finger protein 10)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity; histone acetyltransferase activity; and transcription coregulator activity. Involved in nervous system development. Part of npBAF complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and tooth. Orthologous to human PHF10 (PHD finger protein 10). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromatin remodeling, nervous system development, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: chromatin binding, histone acetyltransferase activity, metal ion binding, protein binding, transcription coregulator activity, zinc ion binding; CC: RSC-type complex, SWI/SNF complex, chromatin, kinetochore, npBAF complex, nuclear matrix, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Hepatocellular carcinoma - Mus musculus (mouse), SWI/SNF chromatin remodelers
UniProt: Q9D8M7
Entrez ID: 72057
|
Does Knockout of Fbxw11 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Fbxw11
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Fbxw11 (F-box and WD-40 domain protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, Wnt signaling pathway, brain morphogenesis, establishment of mitotic spindle orientation, germ cell development, microtubule organizing center organization, negative regulation of canonical NF-kappaB signal transduction, negative regulation of non-canonical NF-kappaB signal transduction, nuclear migration, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of circadian rhythm, positive regulation of proteolysis, proteasome-mediated ubiquitin-dependent protein catabolic process, protein dephosphorylation, protein destabilization, protein polyubiquitination, protein ubiquitination, regulation of circadian rhythm, retrograde axonal transport, rhythmic process, vesicle transport along microtubule; MF: dynein complex binding, microtubule plus-end binding, protein binding, protein dimerization activity, ubiquitin protein ligase activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activity; CC: SCF ubiquitin ligase complex, axon cytoplasm, centrosome, cytoplasm, cytoplasmic microtubule, cytosol, kinetochore, microtubule associated complex, neuron projection, neuronal cell body, nuclear envelope, nucleus
Pathways: Activation of NF-kappaB in B cells, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular senescence - Mus musculus (mouse), Circadian rhythm - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G2/M Transition, Hedgehog signaling pathway - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, Metabolism of proteins, Mitotic G2-G2/M phases, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NIK-->noncanonical NF-kB signaling, Neddylation, Oocyte meiosis - Mus musculus (mouse), Post-translational protein modification, Regulation of PLK1 Activity at G2/M Transition, Signaling by Interleukins, Signaling by the B Cell Receptor (BCR), TCR signaling, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ubiquitin mediated proteolysis - Mus musculus (mouse), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Wnt signaling pathway - Mus musculus (mouse), p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q5SRY7
Entrez ID: 103583
|
Does Knockout of 2700062C07Rik in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
2700062C07Rik
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: 2700062C07Rik (RIKEN cDNA 2700062C07 gene)
Type: protein-coding
Summary: Orthologous to human C18orf21 (chromosome 18 open reading frame 21). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA processing, biological_process; CC: cellular_component, nucleus, ribonuclease MRP complex
Pathways:
UniProt: Q5XFZ0
Entrez ID: 68046
|
Does Knockout of Top2b in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Top2b
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Top2b (topoisomerase (DNA) II beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, DNA metabolic process, DNA topological change, axonogenesis, cellular response to ATP, cellular response to hydrogen peroxide, cellular senescence, forebrain development, neuron migration, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of single stranded viral RNA replication via double stranded DNA intermediate, resolution of meiotic recombination intermediates, sister chromatid segregation; MF: ATP binding, DNA binding, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, chromatin binding, isomerase activity, metal ion binding, nucleotide binding, protein binding, ribonucleoprotein complex binding; CC: cytosol, heterochromatin, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: Q64511
Entrez ID: 21974
|
Does Knockout of Trim40 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Trim40
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Trim40 (tripartite motif-containing 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: innate immune response, negative regulation of cell growth, negative regulation of protein catabolic process, negative regulation of protein localization to nucleus, protein neddylation; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: IkappaB kinase complex, cytoplasm
Pathways:
UniProt: Q3UWA4
Entrez ID: 195359
|
Does Knockout of Rab23 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Rab23
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rab23 (RAB23, member RAS oncogene family)
Type: protein-coding
Summary: Predicted to enable GTPase activity. Involved in dorsal/ventral neural tube patterning and neural tube closure. Acts upstream of or within several processes, including embryonic digit morphogenesis; regulation of smoothened signaling pathway; and spinal cord dorsal/ventral patterning. Located in endosome membrane and plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in Carpenter syndrome 1. Orthologous to human RAB23 (RAB23, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: GTP metabolic process, anatomical structure morphogenesis, autophagosome assembly, cellular defense response, cilium assembly, craniofacial suture morphogenesis, dorsal/ventral neural tube patterning, embryonic digit morphogenesis, intracellular protein transport, negative regulation of protein import into nucleus, negative regulation of proteolysis, nervous system development, neural tube closure, protein transport, regulation of smoothened signaling pathway, signal transduction, spinal cord dorsal/ventral patterning, system development; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding; CC: autophagosome, cell junction, centrosome, ciliary basal body, cilium, cytoplasm, cytoplasmic vesicle, cytosol, endomembrane system, endosome, endosome membrane, membrane, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane
Pathways:
UniProt: M0QWL7, Q9D4I9
Entrez ID: 19335
|
Does Knockout of Nlrp14 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Nlrp14
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Nlrp14 (NLR family, pyrin domain containing 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, regulation of inflammatory response, spermatogenesis; MF: ATP binding, molecular_function, nucleotide binding; CC: cellular_component, cytoplasm
Pathways:
UniProt: Q6B966
Entrez ID: 76858
|
Does Knockout of Epg5 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Epg5
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Epg5 (ectopic P-granules 5 autophagy tethering factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure homeostasis, apoptotic process, autophagosome maturation, autophagy, cellular response to dsDNA, defense response to virus, endocytic recycling, endosome to lysosome transport, gene expression, homeostasis of number of cells, homeostasis of number of retina cells, host-mediated modulation of intestinal microbiota composition, inclusion body assembly, inflammatory response, innate immune response, interferon-mediated signaling pathway, intracellular receptor signaling pathway, maintenance of protein complex location, mucosal immune response, neuron apoptotic process, nucleotide transport, photoreceptor cell differentiation, protein aggregate center assembly, protein catabolic process, response to type III interferon, response to unfolded protein, response to virus, toll-like receptor 9 signaling pathway, ubiquitin-dependent protein catabolic process; CC: cytoplasm, lysosome, perinuclear region of cytoplasm
Pathways:
UniProt: Q80TA9
Entrez ID: 100502841
|
Does Knockout of Tctn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Tctn1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tctn1 (tectonic family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, central nervous system interneuron axonogenesis, cilium assembly, dorsal/ventral neural tube patterning, in utero embryonic development, neural tube formation, protein localization to ciliary transition zone, regulation of smoothened signaling pathway, somatic motor neuron differentiation, telencephalon development; CC: MKS complex, cell projection, ciliary transition zone, cytoplasm, cytoskeleton, extracellular region, extracellular space, membrane
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8BZ64
Entrez ID: 654470
|
Does Knockout of Ccdc183 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Ccdc183
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ccdc183 (coiled-coil domain containing 183)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2AJB1
Entrez ID: 77058
|
Does Knockout of Ifng in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Ifng
|
response to virus
|
Microglial Cell Line
|
Gene: Ifng (interferon gamma)
Type: protein-coding
Summary: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: CD8-positive, alpha-beta T cell differentiation involved in immune response, Fc-gamma receptor signaling pathway involved in phagocytosis, T cell receptor signaling pathway, adaptive immune response, antigen processing and presentation, apoptotic process, astrocyte activation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, cellular response to interleukin-18, cellular response to lipopolysaccharide, creatinine metabolic process, defense response to Gram-positive bacterium, defense response to bacterium, defense response to protozoan, defense response to virus, endoplasmic reticulum unfolded protein response, extrinsic apoptotic signaling pathway, host-mediated activation of viral process, humoral immune response, immune response, inflammatory cell apoptotic process, interleukin-2-mediated signaling pathway, macrophage activation involved in immune response, macrophage differentiation, microglial cell activation, negative regulation of DNA-templated transcription, negative regulation of amyloid-beta clearance, negative regulation of cell population proliferation, negative regulation of epithelial cell differentiation, negative regulation of fibroblast proliferation, negative regulation of gene expression, negative regulation of glomerular mesangial cell proliferation, negative regulation of interleukin-17 production, negative regulation of myelination, negative regulation of osteoclast differentiation, negative regulation of smooth muscle cell proliferation, negative regulation of transcription by RNA polymerase II, neuroinflammatory response, neutrophil apoptotic process, neutrophil chemotaxis, positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response, positive regulation of DNA-templated transcription, positive regulation of MHC class II biosynthetic process, positive regulation of T cell cytokine production, positive regulation of T cell proliferation, positive regulation of amyloid-beta formation, positive regulation of apoptotic process, positive regulation of autophagy, positive regulation of cell adhesion, positive regulation of cell population proliferation, positive regulation of cellular respiration, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of epithelial cell migration, positive regulation of fructose 1,6-bisphosphate metabolic process, positive regulation of gene expression, positive regulation of glutamate receptor signaling pathway, positive regulation of glycolytic process, positive regulation of inflammatory response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-12 production, positive regulation of interleukin-23 production, positive regulation of interleukin-6 production, positive regulation of iron ion import across plasma membrane, positive regulation of isotype switching to IgG isotypes, positive regulation of macrophage cytokine production, positive regulation of membrane protein ectodomain proteolysis, positive regulation of monoatomic ion transmembrane transport, positive regulation of neurogenesis, positive regulation of neuron differentiation, positive regulation of nitric oxide biosynthetic process, positive regulation of osteoclast differentiation, positive regulation of phagocytosis, positive regulation of protein deacetylation, positive regulation of protein import into nucleus, positive regulation of protein-containing complex assembly, positive regulation of receptor signaling pathway via STAT, positive regulation of smooth muscle cell apoptotic process, positive regulation of synaptic transmission, cholinergic, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor (ligand) superfamily member 11 production, positive regulation of tumor necrosis factor production, positive regulation of vitamin D biosynthetic process, regulation of DNA-templated transcription, regulation of defense response to virus by host, regulation of glial cell proliferation, regulation of hepatocyte proliferation, regulation of immune response, regulation of insulin secretion, regulation of nervous system process, regulation of neuronal action potential, regulation of the force of heart contraction, response to sodium arsenite, response to virus, sensory perception of mechanical stimulus, type II interferon-mediated signaling pathway, type III interferon-mediated signaling pathway, urea metabolic process; MF: cytokine activity, protein binding, type II interferon receptor binding; CC: external side of plasma membrane, extracellular region, extracellular space, perikaryon
Pathways: African trypanosomiasis - Mus musculus (mouse), Allograft rejection - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), IFNG signaling activates MAPKs, IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Malaria - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Regulation of IFNG signaling, Rheumatoid arthritis - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse)
UniProt: P01580
Entrez ID: 15978
|
Does Knockout of Taar7a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Taar7a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Taar7a (trace amine-associated receptor 7A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled amine receptor activity, G protein-coupled receptor activity, trace-amine receptor activity; CC: membrane, plasma membrane
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse)
UniProt: Q5QD12
Entrez ID: 215856
|
Does Knockout of Dgki in Microglial Cell Line causally result in phagocytosis?
| 0
| 1,587
|
Knockout
|
Dgki
|
phagocytosis
|
Microglial Cell Line
|
Gene: Dgki (diacylglycerol kinase, iota)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, diacylglycerol metabolic process, excitatory postsynaptic potential, glycerolipid metabolic process, habituation, intracellular signal transduction, lipid metabolic process, lipid phosphorylation, neurotransmitter secretion, phosphatidic acid biosynthetic process, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of Ras protein signal transduction, presynaptic modulation of chemical synaptic transmission, regulation of Ras protein signal transduction, regulation of long-term synaptic depression, regulation of synaptic transmission, glutamatergic, signal transduction; MF: ATP binding, ATP-dependent diacylglycerol kinase activity, GTPase inhibitor activity, kinase activity, nucleotide binding, small GTPase binding, transferase activity; CC: Schaffer collateral - CA1 synapse, axon, axon terminus, cell projection, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, dendritic spine, excitatory synapse, extrinsic component of postsynaptic density membrane, extrinsic component of presynaptic active zone membrane, glutamatergic synapse, guanyl-nucleotide exchange factor complex, membrane, neuronal cell body, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynapse, postsynaptic density, presynapse, presynaptic active zone, protein-containing complex, synapse, synaptic membrane, synaptic vesicle, synaptic vesicle membrane
Pathways: Choline metabolism in cancer - Mus musculus (mouse), Effects of PIP2 hydrolysis, G alpha (q) signalling events, GPCR downstream signalling, Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid metabolism - Mus musculus (mouse), Hemostasis, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation, signaling and aggregation, Signal Transduction, Signaling by GPCR
UniProt: D3YWQ0
Entrez ID: 320127
|
Does Knockout of Dact3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Dact3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dact3 (dishevelled-binding antagonist of beta-catenin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of epithelial to mesenchymal transition; MF: delta-catenin binding, identical protein binding, protein binding, protein kinase A binding, protein kinase C binding; CC: cytoplasm
Pathways:
UniProt: Q0PHV7
Entrez ID: 629378
|
Does Knockout of G430095P16Rik in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
G430095P16Rik
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: G430095P16Rik (RIKEN cDNA G430095P16 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 619292
|
Does Knockout of Actrt2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Actrt2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Actrt2 (actin-related protein T2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: actin cytoskeleton, cytoplasm, cytoskeleton
Pathways:
UniProt: Q9D9L5
Entrez ID: 73353
|
Does Knockout of Sowahc in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Sowahc
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Sowahc (sosondowah ankyrin repeat domain family member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOF GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8C0J6
Entrez ID: 268301
|
Does Knockout of Rnf157 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Rnf157
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rnf157 (ring finger protein 157)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of apoptotic process, positive regulation of dendrite extension, protein ubiquitination; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cell body, cytoplasm
Pathways:
UniProt: F6XBS7, A2AAN9, A2AAP0, F7D0T8
Entrez ID: 217340
|
Does Knockout of Eci3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Eci3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Eci3 (enoyl-Coenzyme A delta isomerase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid beta-oxidation, fatty acid catabolic process; MF: delta(3)-delta(2)-enoyl-CoA isomerase activity, fatty-acyl-CoA binding, intramolecular oxidoreductase activity, transposing C=C bonds, isomerase activity; CC: mitochondrion, peroxisomal matrix, peroxisome
Pathways: Fatty acid degradation - Mus musculus (mouse), Peroxisome - Mus musculus (mouse)
UniProt: Q78JN3
Entrez ID: 69123
|
Does Knockout of C8a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
C8a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: C8a (complement component 8, alpha polypeptide)
Type: protein-coding
Summary: This gene encodes the alpha subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the alpha subunit, which associates with the beta and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the beta subunit. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: complement activation, complement activation, GZMK pathway, complement activation, alternative pathway, complement activation, classical pathway, immune response, immune system process, innate immune response, killing of cells of another organism, positive regulation of immune response; MF: complement binding, metal ion binding, protein-containing complex binding; CC: extracellular region, extracellular space, membrane, membrane attack complex, other organism cell membrane, plasma membrane, transmembrane transporter complex
Pathways: Amoebiasis - Mus musculus (mouse), Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Coronavirus disease - COVID-19 - Mus musculus (mouse), Immune System, Innate Immune System, Prion disease - Mus musculus (mouse), Regulation of Complement cascade, Systemic lupus erythematosus - Mus musculus (mouse), Terminal pathway of complement
UniProt: Q8K182
Entrez ID: 230558
|
Does Knockout of Dzip1l in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Dzip1l
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dzip1l (DAZ interacting protein 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ciliary transition zone assembly, cilium assembly, floor plate development, neural tube patterning, protein localization to cilium, regulation of protein localization, smoothened signaling pathway; MF: metal ion binding, protein binding, zinc ion binding; CC: axoneme, cell projection, centriole, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, intercellular bridge, microtubule cytoskeleton, mitotic spindle, nucleoplasm
Pathways:
UniProt: Q499E4
Entrez ID: 72507
|
Does Knockout of Zfp65 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Zfp65
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp65 (zinc finger protein 65)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8BY64, Q91W94, B8JJX9, A0A286YD24, B8JJY0
Entrez ID: 235907
|
Does Knockout of Ccl24 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ccl24
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ccl24 (C-C motif chemokine ligand 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, chemokine-mediated signaling pathway, chemotaxis, cytoskeleton organization, eosinophil chemotaxis, immune response, inflammatory response, positive regulation of actin filament polymerization, positive regulation of angiogenesis, positive regulation of cell migration, positive regulation of endothelial cell proliferation, positive regulation of eosinophil migration, positive regulation of inflammatory response, regulation of cell shape; MF: CCR chemokine receptor binding, CCR3 chemokine receptor binding, chemokine activity, cytokine activity, receptor ligand activity; CC: extracellular region, extracellular space
Pathways: Chemokine signaling pathway - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q9JKC0
Entrez ID: 56221
|
Does Knockout of Psmd14 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Psmd14
|
response to virus
|
Microglial Cell Line
|
Gene: Psmd14 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked deubiquitination, proteolysis, regulation of proteasomal protein catabolic process, response to ethanol; MF: endopeptidase activator activity, endopeptidase activity, hydrolase activity, metal ion binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, proteasome binding, protein binding; CC: cytosolic proteasome complex, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, lid subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Metalloprotease DUBs, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: O35593
Entrez ID: 59029
|
Does Knockout of Abce1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,170
|
Knockout
|
Abce1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Abce1 (ATP-binding cassette, sub-family E member 1)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: CAT tailing, protein ufmylation, regulation of macromolecule metabolic process, regulation of translation, rescue of stalled ribosome, ribosome disassembly, ribosome-associated ubiquitin-dependent protein catabolic process, translation, translational initiation, translational termination; MF: 4 iron, 4 sulfur cluster binding, ATP binding, ATP hydrolysis activity, CTPase activity, GTPase activity, endoribonuclease inhibitor activity, hydrolase activity, iron ion binding, iron-sulfur cluster binding, metal ion binding, nucleotide binding, ribonucleoside triphosphate phosphatase activity, ribosomal small subunit binding; CC: cytoplasm, cytosol, cytosolic ribosome, mitochondrion
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Immune System, Interferon Signaling, Interferon alpha/beta signaling, Metabolism of proteins, OAS antiviral response, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome-associated quality control, Translation
UniProt: P61222
Entrez ID: 24015
|
Does Knockout of Gm9945 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Gm9945
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gm9945 (predicted gene 9945)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Lin28a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Lin28a
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Lin28a (lin-28 homolog A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, cellular response to glucose stimulus, germ cell development, miRNA catabolic process, miRNA metabolic process, negative regulation of glial cell differentiation, negative regulation of pre-miRNA processing, negative regulation of translation, positive regulation of TOR signaling, positive regulation of cell proliferation involved in kidney development, positive regulation of cytoplasmic translation, positive regulation of neuron differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of translation, post-transcriptional regulation of gene expression, pre-miRNA processing, regulation of miRNA-mediated gene silencing, regulatory ncRNA-mediated gene silencing, stem cell differentiation, stem cell population maintenance; MF: G-quadruplex RNA binding, RNA binding, mRNA binding, metal ion binding, miRNA binding, nucleic acid binding, pre-miRNA binding, protein binding, protein-RNA adaptor activity, sequence-specific mRNA binding, translation initiation factor binding, zinc ion binding; CC: P-body, cytoplasm, cytoplasmic stress granule, cytosol, endoplasmic reticulum, nucleolus, nucleus, rough endoplasmic reticulum
Pathways:
UniProt: Q8K3Y3
Entrez ID: 83557
|
Does Knockout of Lmntd1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Lmntd1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lmntd1 (lamin tail domain containing 1)
Type: protein-coding
Summary: Acts upstream of or within cell population proliferation. Located in cytoplasm and nuclear envelope. Orthologous to human LMNTD1 (lamin tail domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cytoplasm, intermediate filament, nuclear envelope, nucleus
Pathways:
UniProt: Q9D4C1
Entrez ID: 74071
|
Does Knockout of Tbc1d30 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Tbc1d30
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tbc1d30 (TBC1 domain family, member 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cilium assembly; MF: GTPase activator activity, small GTPase binding; CC: ciliary basal body, cilium, cytosol, membrane, nuclear body, plasma membrane
Pathways:
UniProt: Q69ZT9
Entrez ID: 74694
|
Does Knockout of Vmn1r87 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Vmn1r87
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn1r87 (vomeronasal 1 receptor 87)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R255
Entrez ID: 171261
|
Does Knockout of Gria1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Gria1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gria1 (glutamate receptor, ionotropic, AMPA1 (alpha 1))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: behavioral response to pain, calcium-mediated signaling, cellular response to L-glutamate, cellular response to amine stimulus, cellular response to amino acid stimulus, cellular response to ammonium ion, cellular response to brain-derived neurotrophic factor stimulus, cellular response to dsRNA, cellular response to growth factor stimulus, cellular response to peptide hormone stimulus, cerebral cortex development, chemical synaptic transmission, conditioned place preference, ionotropic glutamate receptor signaling pathway, long-term memory, long-term synaptic depression, long-term synaptic potentiation, modulation of chemical synaptic transmission, monoatomic ion transmembrane transport, monoatomic ion transport, neuronal action potential, positive regulation of excitatory postsynaptic potential, positive regulation of gene expression, positive regulation of locomotion involved in locomotory behavior, positive regulation of membrane potential, positive regulation of synaptic transmission, receptor internalization, regulation of monoatomic ion transmembrane transport, regulation of postsynaptic membrane potential, regulation of presynaptic membrane potential, regulation of receptor recycling, regulation of synaptic plasticity, response to arsenic-containing substance, response to cocaine, response to electrical stimulus, response to estradiol, response to ethanol, response to fungicide, response to lithium ion, response to morphine, response to nutrient levels, response to peptide hormone, response to psychosocial stress, response to sucrose, response to toxic substance, response to xenobiotic stimulus, spinal cord development, synapse assembly, synaptic transmission, glutamatergic; MF: AMPA glutamate receptor activity, G-protein alpha-subunit binding, G-protein beta-subunit binding, PDZ domain binding, adenylate cyclase binding, amyloid-beta binding, beta-2 adrenergic receptor binding, glutamate receptor binding, glutamate-gated calcium ion channel activity, glutamate-gated receptor activity, identical protein binding, immunoglobulin binding, ionotropic glutamate receptor binding, ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, monoatomic ion channel activity, myosin V binding, peptide hormone receptor binding, protein binding, protein domain specific binding, protein kinase A binding, protein kinase binding, scaffold protein binding, signaling receptor activity, small GTPase binding, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: AMPA glutamate receptor complex, asymmetric synapse, axonal spine, cell body, cell projection, cell surface, cell-cell junction, cytosol, dendrite, dendrite membrane, dendritic shaft, dendritic spine, dendritic spine membrane, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, excitatory synapse, external side of plasma membrane, glutamatergic synapse, ionotropic glutamate receptor complex, membrane, neuromuscular junction, neuron projection, neuron spine, neuronal cell body, neuronal cell body membrane, perisynaptic space, plasma membrane, postsynapse, postsynaptic density, postsynaptic density membrane, postsynaptic density, intracellular component, postsynaptic membrane, presynapse, presynaptic active zone membrane, presynaptic membrane, protein-containing complex, proximal dendrite, recycling endosome, recycling endosome membrane, somatodendritic compartment, synapse, synaptic membrane, synaptic vesicle, synaptic vesicle membrane
Pathways: Activation of AMPA receptors, Activation of NMDA receptors and postsynaptic events, Amphetamine addiction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, Circadian entrainment - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), ER to Golgi Anterograde Transport, Glutamate binding, activation of AMPA receptors and synaptic plasticity, Glutamatergic synapse - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Membrane Trafficking, Metabolism of proteins, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Protein-protein interactions at synapses, Retrograde endocannabinoid signaling - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Synaptic adhesion-like molecules, Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses, Transport to the Golgi and subsequent modification, Unblocking of NMDA receptors, glutamate binding and activation, Vesicle-mediated transport, cAMP signaling pathway - Mus musculus (mouse)
UniProt: P23818
Entrez ID: 14799
|
Does Knockout of Asxl1 in Non-Small Cell Lung Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,190
|
Knockout
|
Asxl1
|
tumorigenicity
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: Asxl1 (ASXL transcriptional regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, bone development, bone marrow development, cell morphogenesis, chromatin organization, heart morphogenesis, hematopoietic or lymphoid organ development, hemopoiesis, homeostasis of number of cells, lung saccule development, negative regulation of fat cell differentiation, negative regulation of lipid storage, negative regulation of peroxisome proliferator activated receptor signaling pathway, podocyte development, positive regulation of retinoic acid receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of kidney size, response to retinoic acid, thymus development; MF: DNA binding, chromatin binding, metal ion binding, nuclear retinoic acid receptor binding, peroxisome proliferator activated receptor binding, protein binding, transcription coactivator activity, zinc ion binding; CC: PR-DUB complex, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, UCH proteinases
UniProt: P59598
Entrez ID: 228790
|
Does Knockout of Slc35d3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Slc35d3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc35d3 (solute carrier family 35, member D3)
Type: protein-coding
Summary: Enables UDP-glucose transmembrane transporter activity and protein-macromolecule adaptor activity. Involved in UDP-glucose transmembrane transport; platelet dense granule organization; and positive regulation of autophagy. Acts upstream of or within energy homeostasis and positive regulation of protein exit from endoplasmic reticulum. Located in early endosome and endoplasmic reticulum. Is active in early endosome membrane. Is expressed in midbrain mantle layer and thymus primordium. Orthologous to human SLC35D3 (solute carrier family 35 member D3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: UDP-glucose transmembrane transport, energy homeostasis, platelet dense granule organization, positive regulation of autophagy, positive regulation of protein exit from endoplasmic reticulum, transmembrane transport; MF: UDP-glucose transmembrane transporter activity, antiporter activity, protein binding, protein-macromolecule adaptor activity; CC: Golgi apparatus, cytoplasmic vesicle, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, membrane, synapse, synaptic vesicle membrane
Pathways:
UniProt: Q8BGF8
Entrez ID: 76157
|
Does Knockout of Disp3 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Disp3
|
cell proliferation
|
Regulatory T cell
|
Gene: Disp3 (dispatched RND transporter family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cholesterol metabolic process, lipid metabolic process, negative regulation of neuron differentiation, positive regulation of lipid metabolic process, positive regulation of neural precursor cell proliferation, steroid metabolic process; CC: cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus
Pathways:
UniProt: E9QL24
Entrez ID: 242748
|
Does Knockout of Asb4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Asb4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Asb4 (ankyrin repeat and SOCS box-containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, positive regulation of vasculogenesis, protein autoubiquitination, protein ubiquitination; MF: enzyme binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity; CC: Cul2-RING ubiquitin ligase complex, Cul5-RING ubiquitin ligase complex, cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9WV71
Entrez ID: 65255
|
Does Knockout of Zc3h7a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Zc3h7a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zc3h7a (zinc finger CCCH type containing 7 A)
Type: protein-coding
Summary: Predicted to enable miRNA binding activity. Predicted to be involved in miRNA processing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Is expressed in Meckel's cartilage; embryo mesenchyme; and skeleton. Orthologous to human ZC3H7A (zinc finger CCCH-type containing 7A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: miRNA processing, post-transcriptional regulation of gene expression; MF: metal ion binding, miRNA binding, zinc ion binding; CC: cellular_component, nucleus
Pathways:
UniProt: E9PWW6, Q3UBH9, Q8C6Z3, D3YVH9, F6X2N3, D6RI42, D3Z5I3, D3YZY2, E9Q8M5
Entrez ID: 106205
|
Does Knockout of H2-M2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
H2-M2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: H2-M2 (histocompatibility 2, M region locus 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, antigen processing and presentation of peptide antigen via MHC class I, immune response, immune system process, positive regulation of T cell mediated cytotoxicity; MF: 14-3-3 protein binding, TAP binding, TAP1 binding, TAP2 binding, beta-2-microglobulin binding, peptide antigen binding, protein-folding chaperone binding, receptor ligand activity, signaling receptor binding; CC: Golgi apparatus, Golgi membrane, MHC class I protein complex, MHC class Ib protein complex, cell surface, early endosome membrane, endoplasmic reticulum, external side of plasma membrane, extracellular space, lumenal side of endoplasmic reticulum membrane, lysosomal membrane, membrane, phagocytic vesicle membrane, plasma membrane
Pathways: Adaptive Immune System, Allograft rejection - Mus musculus (mouse), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, DAP12 interactions, ER-Phagosome pathway, Endocytosis - Mus musculus (mouse), Endosomal/Vacuolar pathway, Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Neutrophil degranulation, Phagosome - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: Q6W9J6, Q6W9L1
Entrez ID: 14990
|
Does Knockout of Pcdha12 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Pcdha12
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pcdha12 (protocadherin alpha 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q91Y18
Entrez ID: 192164
|
Does Knockout of Thop1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Thop1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Thop1 (thimet oligopeptidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, peptide catabolic process, peptide metabolic process, proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, peptide binding; CC: cytoplasm, mitochondrial intermembrane space
Pathways: Adaptive Immune System, African trypanosomiasis - Mus musculus (mouse), Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Renin-angiotensin system - Mus musculus (mouse)
UniProt: Q8C1A5
Entrez ID: 50492
|
Does Knockout of Bicdl2 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Bicdl2
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Bicdl2 (BICD family like cargo adaptor 2)
Type: protein-coding
Summary: Enables small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and vesicle transport along microtubule. Orthologous to human BICDL2 (BICD family like cargo adaptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi to secretory granule transport, vesicle transport along microtubule
Pathways:
UniProt: Q8CHW5
Entrez ID: 212733
|
Does Knockout of Cln6 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Cln6
|
cell proliferation
|
Regulatory T cell
|
Gene: Cln6 (ceroid-lipofuscinosis, neuronal 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol metabolic process, ganglioside metabolic process, glycosaminoglycan metabolic process, locomotion involved in locomotory behavior, lysosomal lumen acidification, lysosome organization, positive regulation of proteolysis, visual perception; MF: lysophosphatidic acid binding, protein homodimerization activity, sulfatide binding; CC: early endosome, endoplasmic reticulum, endoplasmic reticulum lumen, membrane, membrane raft, nucleolus
Pathways:
UniProt: F6SXC2, Q3U466, F6YAC1, D6RE34
Entrez ID: 76524
|
Does Knockout of Tnip1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Tnip1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tnip1 (TNFAIP3 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MyD88-dependent toll-like receptor signaling pathway, cellular response to lipopolysaccharide, glycoprotein biosynthetic process, inflammatory response, leukocyte cell-cell adhesion, negative regulation of ERK1 and ERK2 cascade, negative regulation of canonical NF-kappaB signal transduction, positive regulation of inflammatory response, positive regulation of macromolecule metabolic process, positive regulation of protein deubiquitination, positive regulation of transcription by RNA polymerase II, regulation of primary metabolic process, regulation of transcription by RNA polymerase II; MF: identical protein binding, mitogen-activated protein kinase binding, polyubiquitin modification-dependent protein binding, protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Ovarian tumor domain proteases, Post-translational protein modification
UniProt: Q9WUU8
Entrez ID: 57783
|
Does Knockout of Msmb in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Msmb
|
response to virus
|
Microglial Cell Line
|
Gene: Msmb (beta-microseminoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: O08540
Entrez ID: 17695
|
Does Knockout of Rab44 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Rab44
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rab44 (RAB44, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: histamine secretion by mast cell, histamine secretion mediated by IgE immunoglobulin, mast cell degranulation, negative regulation of osteoclast differentiation, positive regulation of osteoclast differentiation, vesicle-mediated transport; MF: G protein activity, GTP binding, GTPase activity, nucleotide binding, protein binding; CC: Golgi membrane, early endosome membrane, endoplasmic reticulum membrane, late endosome membrane, lysosomal membrane, membrane, plasma membrane
Pathways: Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB geranylgeranylation
UniProt: Q8CB87
Entrez ID: 442827
|
Does Knockout of Pcdh17 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Pcdh17
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pcdh17 (protocadherin 17)
Type: protein-coding
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: adult behavior, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of synaptic transmission, presynaptic active zone assembly, regulation of synaptic vesicle clustering, synaptic membrane adhesion; MF: calcium ion binding, cell adhesion molecule binding; CC: GABA-ergic synapse, glutamatergic synapse, membrane, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways:
UniProt: Q5HZI5, Q3UTP0, E9PXF0
Entrez ID: 219228
|
Does Knockout of Grap in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Grap
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Grap (GRB2-related adaptor protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, regulation of MAPK cascade, sensory perception of sound, signal transduction; MF: epidermal growth factor receptor binding, phosphotyrosine residue binding; CC: COP9 signalosome, cytoplasm, membrane, nucleoplasm, plasma membrane, presynapse, synapse
Pathways: Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT
UniProt: Q9CX99
Entrez ID: 71520
|
Does Knockout of Paqr8 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Paqr8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Paqr8 (progestin and adipoQ receptor family member VIII)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, nuclear receptor-mediated steroid hormone signaling pathway, oogenesis, response to steroid hormone; MF: lipid binding, nuclear steroid receptor activity, steroid binding; CC: Golgi apparatus, membrane, plasma membrane
Pathways: Chemical carcinogenesis - receptor activation - Mus musculus (mouse)
UniProt: Q80ZE5
Entrez ID: 74229
|
Does Knockout of Smim1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Smim1
|
cell proliferation
|
Regulatory T cell
|
Gene: Smim1 (small integral membrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein homodimerization activity; CC: cell surface, membrane, plasma membrane
Pathways:
UniProt: P0C8K7
Entrez ID: 68859
|
Does Knockout of Galnt9 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Galnt9
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Galnt9 (polypeptide N-acetylgalactosaminyltransferase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein O-linked glycosylation, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, molecular_function, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification
UniProt: G3X942, Q3TB05, A0A0G2JGP7
Entrez ID: 231605
|
Does Knockout of Cdk2ap2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Cdk2ap2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cdk2ap2 (cyclin dependent kinase 2 associated protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of G1/S transition of mitotic cell cycle, regulation of microtubule cytoskeleton organization, regulation of stem cell division; CC: NuRD complex, cytoplasm, microtubule, nucleus
Pathways:
UniProt: Q9CPY4
Entrez ID: 52004
|
Does Knockout of Serpinb9b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Serpinb9b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Serpinb9b (serine (or cysteine) peptidase inhibitor, clade B, member 9b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell mediated cytotoxicity, immune response, negative regulation of apoptotic process, protection from natural killer cell mediated cytotoxicity; MF: cysteine-type endopeptidase inhibitor activity involved in apoptotic process, peptidase inhibitor activity, protease binding, protein binding, serine-type endopeptidase inhibitor activity; CC: Golgi apparatus, cytoplasm, cytosol, extracellular space, nucleoplasm, nucleus
Pathways: Amoebiasis - Mus musculus (mouse)
UniProt: Q9DAV6
Entrez ID: 20706
|
Does Knockout of Fkbp14 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Fkbp14
|
cell cycle progression
|
breast epithelium
|
Gene: Fkbp14 (FK506 binding protein 14)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat P3 isomerase activity; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity; and calcium ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum lumen. Is expressed in cerebral cortex ventricular layer; cranium; jaw; and thoracic segment skeleton. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: MF: calcium ion binding, isomerase activity, metal ion binding, peptidyl-prolyl cis-trans isomerase activity; CC: endoplasmic reticulum, endoplasmic reticulum lumen
Pathways:
UniProt: P59024
Entrez ID: 231997
|
Does Knockout of Tbc1d10a in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Tbc1d10a
|
response to bacteria
|
macrophage
|
Gene: Tbc1d10a (TBC1 domain family, member 10a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteolysis, retrograde transport, endosome to Golgi; MF: GTPase activator activity, PDZ domain binding, guanyl-nucleotide exchange factor activity; CC: cell projection, cytosol, microvillus, plasma membrane
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: P58802
Entrez ID: 103724
|
Does Knockout of Rasal1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Rasal1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rasal1 (RAS protein activator like 1 (GAP1 like))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cellular response to calcium ion, intracellular signal transduction, negative regulation of Ras protein signal transduction, positive regulation of dendrite extension, regulation of intracellular signal transduction; MF: GTPase activator activity, metal ion binding, zinc ion binding; CC: cytosol, plasma membrane
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Regulation of RAS by GAPs, Signal Transduction
UniProt: Q9Z268
Entrez ID: 19415
|
Does Knockout of Pnma3 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Pnma3
|
phagocytosis
|
macrophage
|
Gene: Pnma3 (paraneoplastic antigen MA3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, nucleic acid binding, zinc ion binding; CC: cellular_component, nucleolus, nucleus
Pathways:
UniProt: Q8JZW8
Entrez ID: 245468
|
Does Knockout of Piga in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Piga
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Piga (phosphatidylinositol glycan anchor biosynthesis, class A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, cellular response to leukemia inhibitory factor, lipid metabolic process; MF: glycosyltransferase activity, phosphatidylinositol N-acetylglucosaminyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, membrane
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Synthesis of glycosylphosphatidylinositol (GPI)
UniProt: Q64323
Entrez ID: 18700
|
Does Knockout of Acaa2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Acaa2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Acaa2 (acetyl-CoA acyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA metabolic process, cellular response to hypoxia, fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process, negative regulation of mitochondrial membrane permeability involved in apoptotic process, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; MF: acetyl-CoA C-acetyltransferase activity, acetyl-CoA C-acyltransferase activity, acetyl-CoA hydrolase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, fatty acyl-CoA hydrolase activity, hydrolase activity, transferase activity; CC: ciliary basal body, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nuclear body
Pathways: Fatty acid degradation - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, Valine, leucine and isoleucine degradation - Mus musculus (mouse), fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway)
UniProt: Q8BWT1
Entrez ID: 52538
|
Does Knockout of Fat4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Fat4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fat4 (FAT atypical cadherin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, axonogenesis, branching involved in ureteric bud morphogenesis, cell adhesion, cell-cell adhesion mediated by cadherin, cerebral cortex development, condensed mesenchymal cell proliferation, digestive tract development, epithelial cell differentiation, establishment of planar polarity, fibroblast growth factor receptor signaling pathway, heart morphogenesis, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, hippo signaling, homophilic cell adhesion via plasma membrane adhesion molecules, inner ear receptor cell stereocilium organization, kidney development, nephron development, neurogenesis, ossification involved in bone maturation, plasma membrane organization, regulation of developmental process, regulation of metanephric nephron tubule epithelial cell differentiation, regulation of multicellular organismal process; MF: calcium ion binding, protein binding; CC: adherens junction, apical part of cell, membrane, plasma membrane
Pathways: Hippo signaling pathway - multiple species - Mus musculus (mouse)
UniProt: Q2PZL6
Entrez ID: 329628
|
Does Knockout of Lamc3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Lamc3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lamc3 (laminin gamma 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, astrocyte development, axon guidance, cell adhesion, cell morphogenesis, radial glial cell differentiation, retina development in camera-type eye, sensory organ development, tissue development, visual perception; CC: basement membrane, extracellular region
Pathways: Amoebiasis - Mus musculus (mouse), ECM-receptor interaction - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse)
UniProt: Q9R0B6
Entrez ID: 23928
|
Does Knockout of Mmp25 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Mmp25
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mmp25 (matrix metallopeptidase 25)
Type: protein-coding
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded precursor undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: collagen catabolic process, extracellular matrix organization, hard palate development, proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activator activity, peptidase activity, zinc ion binding; CC: cell surface, extracellular matrix, extracellular space, membrane, plasma membrane, side of membrane
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, Immune System, Innate Immune System, Neutrophil degranulation, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse)
UniProt: Q3U435
Entrez ID: 240047
|
Does Knockout of Fbxo4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Fbxo4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Fbxo4 (F-box protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cellular homeostasis, cellular response to ionizing radiation, cellular senescence, common myeloid progenitor cell proliferation, cytoplasmic translational initiation, negative regulation of fibroblast proliferation, negative regulation of protein localization to nucleus, positive regulation of protein polyubiquitination, positive regulation of protein ubiquitination, positive regulation of telomere maintenance via telomerase, positive regulation of translation, post-transcriptional regulation of gene expression, protein destabilization, protein polyubiquitination, protein ubiquitination, regulation of DNA damage checkpoint, regulation of macromolecule biosynthetic process, regulation of protein stability, telomere maintenance, ubiquitin-dependent protein catabolic process; MF: protein binding, protein homodimerization activity, ubiquitin protein ligase activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activity; CC: SCF ubiquitin ligase complex, cytoplasm, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8CHQ0
Entrez ID: 106052
|
Does Knockout of Naa16 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Naa16
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Naa16 (N(alpha)-acetyltransferase 16, NatA auxiliary subunit)
Type: protein-coding
Summary: Predicted to enable acetyltransferase activator activity and ribosome binding activity. Predicted to be involved in N-terminal protein amino acid acetylation; negative regulation of apoptotic process; and protein stabilization. Predicted to be located in cytosol. Predicted to be part of NatA complex. Predicted to be active in cytoplasm. Orthologous to human NAA16 (N-alpha-acetyltransferase 16, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of apoptotic process, protein stabilization; MF: acetyltransferase activator activity, ribosome binding; CC: NatA complex, cytoplasm, cytosol
Pathways:
UniProt: Q9DBB4
Entrez ID: 66897
|
Does Knockout of Zfp523 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Zfp523
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Zfp523 (zinc finger protein 523)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; limb mesenchyme; oocyte; and urinary system. Orthologous to human ZNF76 (zinc finger protein 76). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8BMU0
Entrez ID: 224656
|
Does Knockout of Pilrb2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Pilrb2
|
cell proliferation
|
Regulatory T cell
|
Gene: Pilrb2 (paired immunoglobin-like type 2 receptor beta 2)
Type: protein-coding
Summary: Predicted to enable MHC class I protein binding activity. Predicted to be located in cell periphery and membrane. Orthologous to human PILRB (paired immunoglobin like type 2 receptor beta). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: CC: membrane, plasma membrane
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q2YFS1
Entrez ID: 545812
|
Does Knockout of Efna2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Efna2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Efna2 (ephrin A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, bone remodeling, ephrin receptor signaling pathway, olfactory bulb development, osteoclast differentiation; MF: ephrin receptor binding, protein binding; CC: membrane, neuromuscular junction, perikaryon, plasma membrane, side of membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, MAPK signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Nervous system development, PI3K-Akt signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse)
UniProt: P52801
Entrez ID: 13637
|
Does Knockout of Clec2h in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Clec2h
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Clec2h (C-type lectin domain family 2, member h)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, natural killer cell lectin-like receptor binding, transmembrane signaling receptor activity; CC: cell surface, endoplasmic reticulum, external side of plasma membrane, membrane, plasma membrane
Pathways: Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse)
UniProt: Q8C1T8
Entrez ID: 94071
|
Does Knockout of Rapgef1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Rapgef1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rapgef1 (Rap guanine nucleotide exchange factor (GEF) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rap protein signal transduction, Ras protein signal transduction, blood vessel development, cell-cell adhesion, cellular response to cAMP, cellular response to nerve growth factor stimulus, establishment of endothelial barrier, negative regulation of ERK1 and ERK2 cascade, negative regulation of Ras protein signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of neural precursor cell proliferation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, nerve growth factor signaling pathway, platelet-derived growth factor receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of Fc receptor mediated stimulatory signaling pathway, positive regulation of neuron projection development, positive regulation of phagocytosis, regulation of JNK cascade, regulation of cell junction assembly, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, protein binding; CC: cytoplasm, early endosome, perinuclear region of cytoplasm, phagocytic vesicle membrane, plasma membrane, protein-containing complex
Pathways: Cytokine Signaling in Immune system, Downstream signal transduction, Erythropoietin activates RAS, Focal adhesion - Mus musculus (mouse), Frs2-mediated activation, Immune System, Insulin signaling pathway - Mus musculus (mouse), Interleukin-3, Interleukin-5 and GM-CSF signaling, MET activates RAP1 and RAC1, MET promotes cell motility, Neurotrophin signaling pathway - Mus musculus (mouse), Prolonged ERK activation events, RAC3 GTPase cycle, RHO GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Regulation of signaling by CBL, Renal cell carcinoma - Mus musculus (mouse), Signal Transduction, Signaling by Erythropoietin, Signaling by Interleukins, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signalling to ERKs
UniProt: A1L338, Q91ZZ2, Q3UHC1, Q3UGX8, A0A5F8MPI9, Q8C5V7, F6ZDE5
Entrez ID: 107746
|
Does Knockout of Slc6a4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Slc6a4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, behavioral response to cocaine, brain morphogenesis, cellular response to cGMP, cellular response to retinoic acid, circadian rhythm, conditioned place preference, enteric nervous system development, male mating behavior, membrane depolarization, memory, monoamine transport, negative regulation of cerebellar granule cell precursor proliferation, negative regulation of neuron differentiation, negative regulation of organ growth, negative regulation of synaptic transmission, dopaminergic, neurotransmitter reuptake, neurotransmitter transport, platelet aggregation, positive regulation of cell cycle, positive regulation of gene expression, positive regulation of serotonin secretion, regulation of thalamus size, response to estradiol, response to hypoxia, response to nutrient, response to toxic substance, response to xenobiotic stimulus, serotonin transport, serotonin uptake, sodium ion transmembrane transport, vasoconstriction; MF: actin filament binding, antiporter activity, cocaine binding, identical protein binding, integrin binding, metal ion binding, monoamine transmembrane transporter activity, monoatomic cation channel activity, neurotransmitter transmembrane transporter activity, nitric-oxide synthase binding, protein binding, serotonin binding, serotonin:sodium:chloride symporter activity, sodium ion binding, syntaxin-1 binding; CC: anchoring junction, cell projection, endomembrane system, endosome, endosome membrane, focal adhesion, membrane, membrane raft, neuron projection, plasma membrane, postsynaptic membrane, presynaptic membrane, serotonergic synapse, synapse
Pathways: Neuronal System, Neurotransmitter clearance, SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Serotonergic synapse - Mus musculus (mouse), Serotonin clearance from the synaptic cleft, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules
UniProt: Q60857
Entrez ID: 15567
|
Does Knockout of Sgca in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Sgca
|
phagocytosis
|
macrophage
|
Gene: Sgca (sarcoglycan, alpha (dystrophin-associated glycoprotein))
Type: protein-coding
Summary: This gene encodes a member of the sarcoglycan alpha/epsilon family of transmembrane proteins. The encoded protein is part of the dystrophin-glycoprotein complex which links the extracellular matrix to the cytoskeleton in muscle fibers. Disruption of this gene results in progressive muscular dystrophy and is associated with the development of embryonal rhabdomysarcoma. [provided by RefSeq, Dec 2012].
Gene Ontology: CC: cell-cell junction, cytoplasm, cytoskeleton, dystroglycan complex, dystrophin-associated glycoprotein complex, membrane, membrane raft, plasma membrane, sarcoglycan complex, sarcolemma
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Hypertrophic cardiomyopathy - Mus musculus (mouse), Non-integrin membrane-ECM interactions, Viral myocarditis - Mus musculus (mouse)
UniProt: P82350
Entrez ID: 20391
|
Does Knockout of Sytl4 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Sytl4
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Sytl4 (synaptotagmin-like 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, intracellular protein transport, lysosome localization, multivesicular body sorting pathway, negative regulation of insulin secretion, plasma membrane repair, positive regulation of exocytosis, positive regulation of protein secretion, regulation of plasma membrane repair; MF: metal ion binding, neurexin family protein binding, phospholipid binding, protein binding, small GTPase binding, zinc ion binding; CC: apical plasma membrane, cytoplasmic vesicle, endosome, exocytic vesicle, membrane, plasma membrane, secretory granule, transport vesicle membrane
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q9R0Q1
Entrez ID: 27359
|
Does Knockout of Mst1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Mst1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mst1 (macrophage stimulating 1 (hepatocyte growth factor-like))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: embryo implantation, mammary duct terminal end bud growth, mammary gland development, negative regulation of epithelial cell apoptotic process, negative regulation of gluconeogenesis, positive regulation of apoptotic process, positive regulation of gene expression, positive regulation of mammary gland epithelial cell proliferation, proteolysis, regulation of cAMP-dependent protein kinase activity, regulation of macromolecule metabolic process, regulation of macrophage chemotaxis, regulation of receptor signaling pathway via JAK-STAT; MF: endopeptidase activity, enzyme binding, histone kinase activity, receptor tyrosine kinase binding; CC: extracellular region, extracellular space, vacuole
Pathways: Calcium signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by MST1, Signaling by Receptor Tyrosine Kinases
UniProt: P26928
Entrez ID: 15235
|
Does Knockout of Gp2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Gp2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gp2 (glycoprotein 2 zymogen granule membrane)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen transcytosis by M cells in mucosal-associated lymphoid tissue, establishment of localization in cell, immune system process, innate immune response, neutrophil migration, organ or tissue specific immune response; MF: antigen binding; CC: apical plasma membrane, cell surface, cytoplasmic vesicle, endosome, external side of plasma membrane, extracellular region, extracellular space, membrane, membrane raft, plasma membrane, side of membrane, zymogen granule membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q9D733
Entrez ID: 67133
|
Does Knockout of Rcsd1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Rcsd1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rcsd1 (RCSD domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular hyperosmotic response, protein localization to endosome, retrograde transport, endosome to Golgi, skeletal muscle contraction; MF: actin filament binding, phosphatidylinositol phosphate binding, retromer complex binding; CC: WASH complex, cellular_component, cytosol, early endosome
Pathways:
UniProt: Q3UZA1
Entrez ID: 226594
|
Does Knockout of Iqcb1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Iqcb1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Iqcb1 (IQ calmodulin-binding motif containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, cytosolic ciliogenesis, maintenance of animal organ identity, photoreceptor cell maintenance; MF: BBSome binding, calmodulin binding, enzyme binding, protein binding, protein-macromolecule adaptor activity; CC: centrosome, cilium, cytoplasm, cytoskeleton, photoreceptor connecting cilium, photoreceptor outer segment
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8BP00
Entrez ID: 320299
|
Does Knockout of Ddx47 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Ddx47
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ddx47 (DEAD box helicase 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic process, extrinsic apoptotic signaling pathway via death domain receptors, mRNA processing, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CWX9
Entrez ID: 67755
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.