prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ostm1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Ostm1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ostm1 (osteopetrosis associated transmembrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: osteoclast differentiation, transepithelial chloride transport; CC: chloride channel complex, cytosol, lysosomal membrane, lysosome, membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q8BGT0
Entrez ID: 14628
|
Does Knockout of Col9a2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Col9a2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Col9a2 (collagen, type IX, alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: extracellular matrix structural constituent conferring tensile strength, protein homodimerization activity; CC: collagen trimer, collagen type IX trimer, extracellular matrix, extracellular region
Pathways: ECM-receptor interaction - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: I7HJR1
Entrez ID: 12840
|
Does Knockout of Taf2 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 1,716
|
Knockout
|
Taf2
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Taf2 (TATA-box binding protein associated factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, RNA polymerase II preinitiation complex assembly, mRNA transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA repair, regulation of transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: RNA polymerase II general transcription initiation factor activity, chromatin binding, transcription cis-regulatory region binding; CC: nucleus, transcription factor TFIID complex, transcription factor TFTC complex
Pathways: Basal transcription factors - Mus musculus (mouse)
UniProt: B9EJX5
Entrez ID: 319944
|
Does Knockout of Grk6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Grk6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Grk6 (G protein-coupled receptor kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, desensitization of G protein-coupled receptor signaling pathway, regulation of signal transduction, signal transduction; MF: ATP binding, G protein-coupled receptor kinase activity, beta-adrenergic receptor kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, membrane
Pathways: Chemokine signaling pathway - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), G alpha (s) signalling events, GPCR downstream signalling, Morphine addiction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: O70293
Entrez ID: 26385
|
Does Knockout of Acbd7 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Acbd7
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Acbd7 (acyl-Coenzyme A binding domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, energy homeostasis, fatty acid metabolic process, gene expression, leptin-mediated signaling pathway, response to food; MF: fatty-acyl-CoA binding, lipid binding
Pathways: Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation
UniProt: Q9D258
Entrez ID: 78245
|
Does Knockout of Arl9 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Arl9
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Arl9 (ADP-ribosylation factor-like 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, GTPase activity, molecular_function, nucleotide binding
Pathways:
UniProt:
Entrez ID: 384185
|
Does Knockout of Trim75 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Trim75
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Trim75 (tripartite motif-containing 75)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: female meiosis I, innate immune response, regulation of gene expression; MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytoskeleton, spindle
Pathways:
UniProt: Q3UWZ0
Entrez ID: 333307
|
Does Knockout of Nfxl1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Nfxl1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nfxl1 (nuclear transcription factor, X-box binding-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: membrane, nucleus
Pathways:
UniProt: Q3ULV1, E9Q8I7, E9Q3K1, E9PZN0
Entrez ID: 100978
|
Does Knockout of Snai2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Snai2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Snai2 (snail family zinc finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, cartilage morphogenesis, cell migration involved in endocardial cushion formation, cellular response to epidermal growth factor stimulus, cellular response to ionizing radiation, cellular response to platelet-derived growth factor stimulus, chromatin organization, desmosome disassembly, endothelial cell migration, epithelial cell migration, epithelial to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, epithelium development, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of anoikis, negative regulation of canonical Wnt signaling pathway, negative regulation of cell adhesion involved in substrate-bound cell migration, negative regulation of cell adhesion mediated by integrin, negative regulation of chondrocyte differentiation, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of hematopoietic stem cell proliferation, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of keratinocyte proliferation, negative regulation of myeloid cell apoptotic process, negative regulation of transcription by RNA polymerase II, negative regulation of vitamin D biosynthetic process, negative regulation of vitamin D receptor signaling pathway, neural crest cell development, osteoblast differentiation, pigmentation, positive regulation of cell migration, positive regulation of endothelial cell chemotaxis, positive regulation of fat cell differentiation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of bicellular tight junction assembly, regulation of branching involved in salivary gland morphogenesis, regulation of chemokine production, regulation of osteoblast differentiation, response to radiation, roof of mouth development, sensory perception of sound, substrate-dependent cell migration, white fat cell differentiation, wound healing, spreading of cells; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Adherens junction - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse)
UniProt: P97469
Entrez ID: 20583
|
Does Knockout of Nmu in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Nmu
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nmu (neuromedin U)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: eating behavior, energy homeostasis, gastric acid secretion, negative regulation of eating behavior, negative regulation of feeding behavior, negative regulation of gastric acid secretion, negative regulation of gastric emptying, neuropeptide signaling pathway, photoperiodism, positive regulation of cytosolic calcium ion concentration, positive regulation of heart rate, positive regulation of heat generation, positive regulation of hormone secretion, positive regulation of prolactin secretion, positive regulation of sensory perception of pain, positive regulation of smooth muscle contraction, positive regulation of stomach fundus smooth muscle contraction, positive regulation of synaptic transmission, positive regulation of systemic arterial blood pressure, regulation of circadian sleep/wake cycle, sleep, regulation of feeding behavior, regulation of grooming behavior, regulation of smooth muscle contraction, temperature homeostasis; MF: neuromedin U receptor binding, type 1 neuromedin U receptor binding, type 2 neuromedin U receptor binding; CC: extracellular region, terminal bouton
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9QXK8
Entrez ID: 56183
|
Does Knockout of Pdcd5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Pdcd5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pdcd5 (programmed cell death 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to transforming growth factor beta stimulus, negative regulation of protein folding, positive regulation of apoptotic process, positive regulation of gene expression, regulation of apoptotic process; MF: DNA binding, acetyltransferase activator activity, beta-tubulin binding, heparin binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: P56812
Entrez ID: 56330
|
Does Knockout of Zfp551 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Zfp551
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zfp551 (zinc finger protein 551)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: B2RUI1
Entrez ID: 619331
|
Does Knockout of Rab35 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Rab35
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rab35 (RAB35, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rab protein signal transduction, antigen processing and presentation, cellular response to nerve growth factor stimulus, endocytic recycling, endosomal transport, intracellular protein localization, mitotic cytokinesis, neuron projection development, plasma membrane to endosome transport, protein localization to endosome, protein transport; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: cell projection membrane, clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle, cytoplasmic vesicle, endosome, endosome membrane, intercellular bridge, melanosome, membrane, mitochondrion, plasma membrane, synaptic vesicle membrane
Pathways: Endocytosis - Mus musculus (mouse), Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q6PHN9
Entrez ID: 77407
|
Does Knockout of Pcyox1l in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Pcyox1l
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Pcyox1l (prenylcysteine oxidase 1 like)
Type: protein-coding
Summary: Predicted to enable prenylcysteine oxidase activity. Involved in neutrophil-mediated killing of bacterium. Predicted to be located in extracellular region. Orthologous to human PCYOX1L (prenylcysteine oxidase 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: neutrophil-mediated killing of bacterium, prenylated protein catabolic process, prenylcysteine catabolic process; MF: oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor, prenylcysteine oxidase activity
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q8C7K6
Entrez ID: 240334
|
Does Knockout of Chrng in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Chrng
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Chrng (cholinergic receptor, nicotinic, gamma polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine receptor signaling pathway, chemical synaptic transmission, excitatory postsynaptic potential, membrane depolarization, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of membrane potential, regulation of postsynaptic membrane potential, skeletal muscle contraction, synaptic transmission, cholinergic; MF: acetylcholine receptor activity, acetylcholine-gated monoatomic cation-selective channel activity, extracellular ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, protein binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: acetylcholine-gated channel complex, membrane, neuron projection, plasma membrane, postsynaptic membrane, synapse
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse)
UniProt: H8YHW6, F8VQK4, I0B502, A0A087WP27
Entrez ID: 11449
|
Does Knockout of Gja10 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Gja10
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Gja10 (gap junction protein, alpha 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, cell-cell signaling, detection of light stimulus involved in visual perception, gamete generation, response to light stimulus, synapse assembly, transmembrane transport; MF: gap junction channel activity; CC: anchoring junction, connexin complex, gap junction, membrane, plasma membrane
Pathways:
UniProt:
Entrez ID: 14610
|
Does Knockout of Tmem127 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Tmem127
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tmem127 (transmembrane protein 127)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome organization, negative regulation of TOR signaling, negative regulation of cell population proliferation, regulation of TOR signaling; MF: small GTPase binding; CC: cytoplasm, early endosome, membrane, plasma membrane
Pathways:
UniProt: Q8BGP5
Entrez ID: 69470
|
Does Knockout of Lrg1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Lrg1
|
cell proliferation
|
Regulatory T cell
|
Gene: Lrg1 (leucine-rich alpha-2-glycoprotein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brown fat cell differentiation, keratinocyte migration, leukocyte adhesion to vascular endothelial cell, positive regulation of angiogenesis, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell proliferation involved in wound healing, positive regulation of epithelial to mesenchymal transition, positive regulation of keratinocyte proliferation, positive regulation of transforming growth factor beta receptor signaling pathway, potassium ion transmembrane transport, response to bacterium, wound healing, spreading of epidermal cells; MF: potassium channel activator activity, protein binding, transforming growth factor beta receptor binding, transmembrane transporter binding, type I transforming growth factor beta receptor binding, type II transforming growth factor beta receptor binding, voltage-gated potassium channel activity; CC: extracellular space, voltage-gated potassium channel complex
Pathways:
UniProt: Q91XL1
Entrez ID: 76905
|
Does Knockout of Polr2m in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Polr2m
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Polr2m (polymerase (RNA) II (DNA directed) polypeptide M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of ER location, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, molecular_function, transcription elongation factor activity; CC: DNA-directed RNA polymerase complex, I band, RNA polymerase II, core complex, neuronal cell body, nuclear envelope, nucleus, transcription preinitiation complex
Pathways:
UniProt: Q6P6I6
Entrez ID: 28015
|
Does Knockout of Gm21835 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm21835
|
phagocytosis
|
macrophage
|
Gene: Gm21835 (predicted gene, 21835)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Zfp524 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Zfp524
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp524 (zinc finger protein 524)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: Q9D0B1
Entrez ID: 66056
|
Does Knockout of Tnks2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Tnks2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tnks2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)
Type: protein-coding
Summary: Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Acts upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; eye; and genitourinary system. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, multicellular organism growth, negative regulation of telomere maintenance via telomere lengthening, positive regulation of canonical Wnt signaling pathway, positive regulation of telomere capping, protein auto-ADP-ribosylation, protein localization to chromosome, telomeric region, protein poly-ADP-ribosylation, protein polyubiquitination, regulation of multicellular organism growth, telomere maintenance; MF: NAD+ poly-ADP-ribosyltransferase activity, NAD+-protein mono-ADP-ribosyltransferase activity, NAD+-protein-aspartate ADP-ribosyltransferase activity, NAD+-protein-glutamate ADP-ribosyltransferase activity, enzyme binding, glycosyltransferase activity, metal ion binding, nucleotidyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, chromosome, chromosome, telomeric region, cytoplasm, membrane, nuclear envelope, nucleus, pericentriolar material, perinuclear region of cytoplasm
Pathways: Degradation of AXIN, Deubiquitination, Intracellular signaling by second messengers, Metabolism of proteins, PIP3 activates AKT signaling, PTEN Regulation, Post-translational protein modification, Regulation of PTEN stability and activity, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Ub-specific processing proteases
UniProt: Q3UES3
Entrez ID: 74493
|
Does Knockout of Ythdf2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Ythdf2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ythdf2 (YTH N6-methyladenosine RNA binding protein 2)
Type: protein-coding
Summary: Enables N6-methyladenosine-containing RNA reader activity. Involved in several processes, including hematopoietic stem cell proliferation; negative regulation of gene expression; and spermatogonial cell division. Located in cytoplasm and nucleus. Is expressed in brain; intestine; and liver. Orthologous to human YTHDF2 (YTH N6-methyladenosine RNA binding protein F2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, cell division, embryonic morphogenesis, endothelial to hematopoietic transition, gamete generation, hematopoietic stem cell proliferation, immune system process, innate immune response, mRNA catabolic process, mRNA destabilization, negative regulation of Notch signaling pathway, negative regulation of stem cell differentiation, negative regulation of type I interferon-mediated signaling pathway, oocyte maturation, oogenesis, organelle assembly, positive regulation of cap-independent translational initiation, positive regulation of translational initiation, regulation of cell adhesion, regulation of hematopoietic stem cell differentiation, regulation of mRNA stability, regulation of meiotic cell cycle process involved in oocyte maturation, regulation of neurogenesis, regulation of rRNA processing, spermatogenesis, spermatogonial cell division, stress granule assembly; MF: C5-methylcytidine-containing RNA reader activity, N6-methyladenosine-containing RNA reader activity, RNA binding, mRNA binding; CC: P-body, centriolar satellite, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, nucleus
Pathways:
UniProt: Q91YT7
Entrez ID: 213541
|
Does Knockout of Nsmce3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Nsmce3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Nsmce3 (NSE3 homolog, SMC5-SMC6 complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cellular response to UV, cellular response to hydroxyurea, cellular response to radiation, negative regulation of transcription by RNA polymerase II, positive regulation of protein ubiquitination, regulation of DNA-templated transcription, regulation of macromolecule metabolic process, regulation of primary metabolic process; MF: protein binding, protein dimerization activity; CC: Smc5-Smc6 complex, chromosome, chromosome, telomeric region, cytoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q9CPR8
Entrez ID: 66647
|
Does Knockout of Ppp3r2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Ppp3r2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ppp3r2 (protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcineurin-mediated signaling, negative regulation of calcium ion import across plasma membrane, penetration of zona pellucida, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of calcium ion import across plasma membrane; MF: calcium ion binding, calcium-dependent protein serine/threonine phosphatase regulator activity, metal ion binding, phosphatase binding, protein binding; CC: calcineurin complex, cytosol, mitochondrion, protein serine/threonine phosphatase complex, sperm flagellum, sperm midpiece, sperm mitochondrial sheath
Pathways: Alzheimer disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q63811
Entrez ID: 19059
|
Does Knockout of Cd177 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Cd177
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cd177 (CD177 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, cell-cell junction maintenance, immune system process, innate immune response, leukocyte cell-cell adhesion, neutrophil extravasation, neutrophil migration, positive regulation of neutrophil degranulation, positive regulation of superoxide anion generation, protein localization to cell surface, regulation of endocytosis, regulation of integrin-mediated signaling pathway; MF: calcium-dependent protein binding, integrin binding, protease binding; CC: membrane, plasma membrane, plasma membrane raft, secretory granule membrane, tertiary granule membrane
Pathways: Cell surface interactions at the vascular wall, Common Pathway of Fibrin Clot Formation, Formation of Fibrin Clot (Clotting Cascade), Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q8R2S8
Entrez ID: 68891
|
Does Knockout of Kank2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Kank2
|
cell cycle progression
|
breast epithelium
|
Gene: Kank2 (KN motif and ankyrin repeat domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, kidney epithelium development, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of actin filament polymerization, negative regulation of cell population proliferation, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of programmed cell death, negative regulation of stress fiber assembly, negative regulation of transcription by RNA polymerase II, negative regulation of vitamin D receptor signaling pathway, podocyte cell migration, regulation of Rho protein signal transduction; CC: cytoplasm, mitochondrion
Pathways:
UniProt: Q8BX02
Entrez ID: 235041
|
Does Knockout of Naa30 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Naa30
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Naa30 (N(alpha)-acetyltransferase 30, NatC catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, protein N-terminal-methionine acetyltransferase activity, protein-N-terminal amino-acid acetyltransferase activity, transferase activity; CC: NatC complex, cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8CES0
Entrez ID: 70646
|
Does Knockout of Bysl in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Bysl
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Bysl (bystin-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, in utero embryonic development, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis, stem cell proliferation, trophectodermal cell differentiation; CC: apical part of cell, cell projection, chromosome, cytoplasm, cytoplasmic microtubule, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O54825
Entrez ID: 53414
|
Does Knockout of Polk in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Polk
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Polk (polymerase (DNA directed), kappa)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, cellular response to UV, error-prone translesion synthesis, nucleotide-excision repair, DNA gap filling; MF: DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, damaged DNA binding, metal ion binding, molecular adaptor activity, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: nuclear body, nucleoplasm, nucleus, site of DNA damage
Pathways: Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Fanconi anemia pathway - Mus musculus (mouse), Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatocellular carcinoma - Mus musculus (mouse), Homology Directed Repair, Melanoma - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Nucleotide Excision Repair, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Termination of translesion DNA synthesis, Thyroid cancer - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional misregulation in cancer - Mus musculus (mouse), Translesion synthesis by POLK, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9QUG2
Entrez ID: 27015
|
Does Knockout of Gm13090 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Gm13090
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gm13090 (predicted gene 13090)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 105704528
|
Does Knockout of Gm16253 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Gm16253
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gm16253 (predicted gene 16253)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Alg2 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Alg2
|
phagocytosis
|
macrophage
|
Gene: Alg2 (ALG2 alpha-1,3/1,6-mannosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity, GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity, alpha-1,3-mannosyltransferase activity, glycosyltransferase activity, transferase activity; CC: cytoplasmic side of endoplasmic reticulum membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q9DBE8
Entrez ID: 56737
|
Does Knockout of Eepd1 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Eepd1
|
phagocytosis
|
macrophage
|
Gene: Eepd1 (endonuclease/exonuclease/phosphatase family domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, positive regulation of cholesterol efflux; MF: DNA binding, catalytic activity; CC: plasma membrane
Pathways:
UniProt: Q3TGW2
Entrez ID: 67484
|
Does Knockout of Trim72 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Trim72
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Trim72 (tripartite motif-containing 72)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, innate immune response, muscle organ development, muscle system process, negative regulation of insulin receptor signaling pathway, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of myotube differentiation, plasma membrane repair, proteasome-mediated ubiquitin-dependent protein catabolic process, protein homooligomerization, vesicle budding from membrane; MF: identical protein binding, metal ion binding, mitogen-activated protein kinase kinase kinase binding, phosphatidylserine binding, protein binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, plasma membrane, sarcolemma
Pathways:
UniProt: Q1XH17
Entrez ID: 434246
|
Does Knockout of Gpr174 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,174
|
Knockout
|
Gpr174
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Gpr174 (G protein-coupled receptor 174)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, T cell homeostasis, adenylate cyclase-activating G protein-coupled receptor signaling pathway, negative regulation of interleukin-2 production, signal transduction; MF: G protein-coupled receptor activity, bioactive lipid receptor activity; CC: centriolar satellite, membrane, plasma membrane
Pathways:
UniProt: Q3U507
Entrez ID: 213439
|
Does Knockout of Hcst in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Hcst
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hcst (hematopoietic cell signal transducer)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: natural killer cell mediated cytotoxicity, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of immune response; MF: phosphatidylinositol 3-kinase binding, protein binding, protein-macromolecule adaptor activity, signaling receptor binding; CC: cell surface, membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: Q9QUJ0
Entrez ID: 23900
|
Does Knockout of Sgce in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Sgce
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sgce (sarcoglycan, epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, cell projection, cytoplasm, cytoskeleton, dendrite, dendrite membrane, dystrophin-associated glycoprotein complex, membrane, plasma membrane, sarcoglycan complex, sarcolemma
Pathways: Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Non-integrin membrane-ECM interactions
UniProt: O70258
Entrez ID: 20392
|
Does Knockout of Pif1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,539
|
Knockout
|
Pif1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Pif1 (PIF1 5'-to-3' DNA helicase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, negative regulation of telomere maintenance via telomerase, protein-DNA-RNA complex disassembly, telomere maintenance; MF: 5'-3' DNA helicase activity, 5'-3' DNA/RNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, G-quadruplex DNA binding, helicase activity, hydrolase activity, isomerase activity, magnesium ion binding, nucleotide binding, protein binding, single-stranded DNA helicase activity, telomerase inhibitor activity, telomeric DNA binding; CC: chromosome, telomeric region, mitochondrial nucleoid, mitochondrion, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q80SX8
Entrez ID: 208084
|
Does Knockout of Atp6v1b1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Atp6v1b1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atp6v1b1 (ATPase, H+ transporting, lysosomal V1 subunit B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, adult behavior, calcium ion homeostasis, chloride ion homeostasis, inner ear morphogenesis, monoatomic ion transport, olfactory behavior, ossification, pH reduction, potassium ion homeostasis, prostaglandin metabolic process, proton transmembrane transport, regulation of gene expression, regulation of pH, renal sodium excretion, renal sodium ion transport, renal tubular secretion, renal water homeostasis, sensory perception of sound, synaptic vesicle lumen acidification, vacuolar acidification, vacuolar proton-transporting V-type ATPase complex assembly; MF: ATP binding, nucleotide binding, protein-containing complex binding, proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, basolateral plasma membrane, cytoplasm, cytosol, extrinsic component of synaptic vesicle membrane, lateral plasma membrane, membrane, microvillus, plasma membrane, proton-transporting V-type ATPase, V1 domain, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q91YH6
Entrez ID: 110935
|
Does Knockout of Slc5a3 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Slc5a3
|
response to bacteria
|
macrophage
|
Gene: Slc5a3 (solute carrier family 5 (inositol transporters), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate transmembrane transport, hexose transmembrane transport, inositol metabolic process, monoatomic ion transport, myo-inositol transport, peripheral nervous system development, positive regulation of protein localization to membrane, positive regulation of reactive oxygen species biosynthetic process, regulation of respiratory gaseous exchange, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: D-glucose:sodium symporter activity, myo-inositol:sodium symporter activity, potassium channel regulator activity, protein binding, symporter activity, transmembrane transporter activity, transmembrane transporter binding; CC: apical plasma membrane, basolateral plasma membrane, membrane, perinuclear region of cytoplasm, plasma membrane, voltage-gated potassium channel complex
Pathways: Inositol transporters, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q9JKZ2
Entrez ID: 53881
|
Does Knockout of Trip4 in cardiac muscle cell line causally result in protein/peptide accumulation?
| 0
| 1,662
|
Knockout
|
Trip4
|
protein/peptide accumulation
|
cardiac muscle cell line
|
Gene: Trip4 (thyroid hormone receptor interactor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen receptor signaling pathway, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of myoblast differentiation, rescue of stalled ribosome, ribosome disassembly, ribosome-associated ubiquitin-dependent protein catabolic process; MF: histone acetyltransferase binding, metal ion binding, nuclear estrogen receptor binding, nuclear receptor binding, protease binding, protein kinase binding, transcription coactivator activity, ubiquitin-like protein ligase binding, zinc ion binding; CC: RQC-trigger complex, centrosome, cytoplasm, cytoskeleton, cytosol, neuromuscular junction, nuclear body, nucleoplasm, nucleus, protein-containing complex
Pathways: Metabolism of proteins, Ribosome-associated quality control, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
UniProt: Q9QXN3
Entrez ID: 56404
|
Does Knockout of Serpinf1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Serpinf1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Serpinf1 (serine (or cysteine) peptidase inhibitor, clade F, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to cobalt ion, cellular response to dexamethasone stimulus, cellular response to glucose stimulus, cellular response to retinoic acid, kidney development, negative regulation of angiogenesis, negative regulation of endothelial cell migration, negative regulation of epithelial cell proliferation involved in prostate gland development, negative regulation of gene expression, ovulation cycle, positive regulation of neurogenesis, positive regulation of neuron projection development, response to acidic pH, response to arsenic-containing substance, response to peptide, retina development in camera-type eye, short-term memory; MF: serine-type endopeptidase inhibitor activity; CC: axon, axon hillock, basement membrane, extracellular region, extracellular space, melanosome, neuronal cell body, perinuclear region of cytoplasm
Pathways: Wnt signaling pathway - Mus musculus (mouse)
UniProt: P97298
Entrez ID: 20317
|
Does Knockout of Spef2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Spef2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Spef2 (sperm flagellar 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain morphogenesis, cell differentiation, cerebrospinal fluid circulation, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, mucociliary clearance, respiratory system development, skeletal system morphogenesis, sperm axoneme assembly, sperm flagellum assembly, spermatogenesis; CC: Golgi apparatus, cell projection, cilium, cytoplasm, cytoskeleton, cytosol, extracellular region, manchette, motile cilium, nuclear body, sperm flagellum, sperm midpiece
Pathways:
UniProt: Q8C9J3
Entrez ID: 320277
|
Does Knockout of Rassf1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Rassf1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rassf1 (Ras association (RalGDS/AF-6) domain family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, Ras protein signal transduction, positive regulation of protein ubiquitination, protein stabilization, regulation of cell cycle, regulation of cell cycle G1/S phase transition, signal transduction; MF: identical protein binding, metal ion binding, protein binding, small GTPase binding, zinc ion binding; CC: centrosome, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, nucleus, spindle, spindle pole
Pathways: Bladder cancer - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Hippo signaling pathway - multiple species - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse)
UniProt: Q99MK9
Entrez ID: 56289
|
Does Knockout of Asphd2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Asphd2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Asphd2 (aspartate beta-hydroxylase domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: dioxygenase activity, metal ion binding, molecular_function, oxidoreductase activity
Pathways:
UniProt: Q80VP9
Entrez ID: 72898
|
Does Knockout of Rrm1 in Microglial Cell Line causally result in response to virus?
| 1
| 1,908
|
Knockout
|
Rrm1
|
response to virus
|
Microglial Cell Line
|
Gene: Rrm1 (ribonucleotide reductase M1)
Type: protein-coding
Summary: Enables disordered domain specific binding activity; purine nucleotide binding activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in several processes, including nucleoside phosphate metabolic process; positive regulation of G0 to G1 transition; and protein heterotetramerization. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: 2'-deoxyribonucleotide biosynthetic process, DNA repair, DNA synthesis involved in DNA repair, cell proliferation in forebrain, deoxyribonucleotide biosynthetic process, male gonad development, mitochondrial DNA replication, positive regulation of G0 to G1 transition, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of G2/M transition of mitotic cell cycle, protein heterotetramerization, pyrimidine nucleobase metabolic process, response to ionizing radiation, retina development in camera-type eye, ribonucleoside diphosphate metabolic process; MF: ATP binding, catalytic activity, disordered domain specific binding, identical protein binding, nucleotide binding, oxidoreductase activity, protein binding, purine nucleotide binding, ribonucleoside-diphosphate reductase activity, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; CC: cell projection, centriolar satellite, ciliary basal body, cytoplasm, cytosol, mitochondrion, neuronal cell body, nuclear envelope, ribonucleoside-diphosphate reductase complex
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse), Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), adenosine nucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis I
UniProt: P07742
Entrez ID: 20133
|
Does Knockout of Zwint in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Zwint
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Zwint (ZW10 interactor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, establishment of localization in cell, homologous chromosome orientation in meiotic metaphase I, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, regulation of meiosis I spindle assembly checkpoint; CC: Knl1/Spc105 complex, chromosome, chromosome, centromeric region, cytoplasm, cytosol, dendrite, kinetochore, nuclear body, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CQU5
Entrez ID: 52696
|
Does Knockout of Cdc45 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,551
|
Knockout
|
Cdc45
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Cdc45 (cell division cycle 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication initiation, double-strand break repair via break-induced replication, mitotic DNA replication preinitiation complex assembly; MF: DNA replication origin binding, chromatin binding, single-stranded DNA binding; CC: CMG complex, DNA replication preinitiation complex, centrosome, ciliary basal body, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition
UniProt: Q9Z1X9
Entrez ID: 12544
|
Does Knockout of Ptch1 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Ptch1
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Ptch1 (patched 1)
Type: protein-coding
Summary: Enables cyclin binding activity; heparin binding activity; and patched binding activity. Involved in several processes, including cellular response to cholesterol; chordate embryonic development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including chordate embryonic development; epithelial tube morphogenesis; and limb morphogenesis. Located in cilium; midbody; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Used to study basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in carcinoma (multiple); holoprosencephaly (multiple); nevoid basal cell carcinoma syndrome (multiple); and stomach cancer. Orthologous to human PTCH1 (patched 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: animal organ morphogenesis, brain development, branching involved in ureteric bud morphogenesis, cell differentiation involved in kidney development, cell fate determination, cell proliferation involved in metanephros development, cellular response to cholesterol, commissural neuron axon guidance, dorsal/ventral neural tube patterning, dorsal/ventral pattern formation, embryonic limb morphogenesis, embryonic organ development, epidermal cell fate specification, epidermis development, glucose homeostasis, heart morphogenesis, hindlimb morphogenesis, in utero embryonic development, keratinocyte proliferation, limb morphogenesis, liver regeneration, mammary gland development, mammary gland duct morphogenesis, mammary gland epithelial cell differentiation, metanephric collecting duct development, negative regulation of DNA-templated transcription, negative regulation of cell division, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation, negative regulation of keratinocyte proliferation, negative regulation of multicellular organism growth, negative regulation of osteoblast differentiation, negative regulation of smoothened signaling pathway, negative regulation of stem cell proliferation, negative regulation of transcription by RNA polymerase II, neural plate axis specification, neural tube closure, neural tube formation, neural tube patterning, pattern specification process, pharyngeal system development, positive regulation of DNA-templated transcription, positive regulation of cholesterol efflux, positive regulation of epidermal cell differentiation, prostate gland development, protein localization to plasma membrane, protein processing, regulation of cell population proliferation, regulation of growth, regulation of mitotic cell cycle, regulation of protein localization, response to alkaloid, response to chlorate, response to estradiol, response to mechanical stimulus, response to retinoic acid, response to xenobiotic stimulus, signal transduction, smooth muscle tissue development, somite development, spermatid development, spinal cord motor neuron differentiation, stem cell proliferation; MF: cholesterol binding, cyclin binding, hedgehog family protein binding, hedgehog receptor activity, heparin binding, patched binding, protein binding, protein-containing complex binding, smoothened binding, zinc ion binding; CC: Golgi apparatus, apical part of cell, axonal growth cone, caveola, cilium, dendritic growth cone, extracellular region, membrane, midbody, perinuclear region of cytoplasm, plasma membrane, postsynaptic membrane
Pathways: Activation of SMO, Axon guidance - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog signaling pathway - Mus musculus (mouse), Ligand-receptor interactions, Pathways in cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signal Transduction, Signaling by Hedgehog, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q61115
Entrez ID: 19206
|
Does Knockout of Sorbs1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Sorbs1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Sorbs1 (sorbin and SH3 domain containing 1)
Type: protein-coding
Summary: Enables enzyme binding activity; insulin receptor binding activity; and signaling receptor complex adaptor activity. Involved in several processes, including focal adhesion assembly; insulin receptor signaling pathway; and positive regulation of biosynthetic process. Acts upstream of or within acetylcholine receptor signaling pathway and regulation of skeletal muscle acetylcholine-gated channel clustering. Located in several cellular components, including adherens junction; nuclear matrix; and stress fiber. Part of flotillin complex. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; central nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human SORBS1 (sorbin and SH3 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: acetylcholine receptor signaling pathway, cell-substrate adhesion, cellular response to insulin stimulus, focal adhesion assembly, insulin receptor signaling pathway, positive regulation of D-glucose import, positive regulation of glycogen biosynthetic process, positive regulation of insulin receptor signaling pathway, positive regulation of lipid biosynthetic process, positive regulation of protein localization to plasma membrane, regulation of skeletal muscle acetylcholine-gated channel clustering, stress fiber assembly; MF: insulin receptor binding, protein binding, protein kinase binding, signaling receptor complex adaptor activity, ubiquitin protein ligase binding; CC: adherens junction, anchoring junction, cell-substrate junction, centrosome, cytoplasm, cytoskeleton, cytosol, flotillin complex, focal adhesion, membrane, membrane raft, nuclear matrix, nucleus, plasma membrane, stress fiber, synapse
Pathways: Adherens junction - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), PPAR signaling pathway - Mus musculus (mouse)
UniProt: Q62417
Entrez ID: 20411
|
Does Knockout of Cyp27b1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Cyp27b1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cyp27b1 (cytochrome P450, family 27, subfamily b, polypeptide 1)
Type: protein-coding
Summary: Enables calcidiol 1-monooxygenase activity. Involved in calcitriol biosynthetic process from calciol; response to vitamin D; and vitamin D catabolic process. Acts upstream of or within calcium ion transport. Located in mitochondrion. Is expressed in several structures, including extraembryonic component; lower jaw molar; metanephros; and reproductive system. Used to study rickets. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G1 to G0 transition, bone mineralization, calcitriol biosynthetic process from calciol, calcium ion homeostasis, calcium ion transport, cellular response to vitamin D, decidualization, lipid metabolic process, negative regulation of bone trabecula formation, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of ossification, positive regulation of keratinocyte differentiation, positive regulation of parathyroid hormone secretion, positive regulation of vitamin D receptor signaling pathway, regulation of bone mineralization, response to cAMP, response to copper ion, response to estrogen, response to insulin, response to lipopolysaccharide, response to prostaglandin E, response to type II interferon, response to vitamin D, response to xenobiotic stimulus, vitamin D biosynthetic process, vitamin D catabolic process, vitamin D metabolic process; MF: calcidiol 1-monooxygenase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, secalciferol 1-monooxygenase activity; CC: cytoplasm, membrane, mitochondrial membrane, mitochondrion
Pathways: 1,25-dihydroxyvitamin D<sub>3</sub> biosynthesis, Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolism, Metabolism of lipids, Metabolism of steroids, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Phase I - Functionalization of compounds, Steroid biosynthesis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Vitamin D (calciferol) metabolism, Vitamins
UniProt: O35084
Entrez ID: 13115
|
Does Knockout of Myh13 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Myh13
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Myh13 (myosin, heavy polypeptide 13, skeletal muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to starvation, muscle contraction; MF: ATP binding, actin binding, actin filament binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding; CC: cytoplasm, myofibril, myosin II complex, myosin complex, myosin filament
Pathways:
UniProt: M0QWL0, B1AR69
Entrez ID: 544791
|
Does Knockout of Fmo5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Fmo5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fmo5 (flavin containing monooxygenase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, regulation of cholesterol metabolic process, xenobiotic metabolic process; MF: N,N-dimethylaniline monooxygenase activity, NAD(P)H oxidase H2O2-forming activity, NADP binding, flavin adenine dinucleotide binding, monooxygenase activity, oxidoreductase activity; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Drug metabolism - cytochrome P450 - Mus musculus (mouse), nicotine degradation II
UniProt: P97872
Entrez ID: 14263
|
Does Knockout of Stoml2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Stoml2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Stoml2 (stomatin (Epb7.2)-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD4-positive, alpha-beta T cell activation, T cell receptor signaling pathway, intracellular calcium ion homeostasis, lipid localization, mitochondrial protein processing, mitochondrion localization, mitochondrion organization, positive regulation of interleukin-2 production, protein complex oligomerization, proton motive force-driven mitochondrial ATP synthesis, stress-induced mitochondrial fusion; MF: GTPase binding, T cell receptor binding, cardiolipin binding, lipid binding; CC: actin cytoskeleton, cytoplasm, cytoskeleton, immunological synapse, membrane, membrane raft, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, plasma membrane
Pathways: Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Mitochondrial calcium ion transport, Processing of SMDT1, Transport of small molecules
UniProt: Q99JB2
Entrez ID: 66592
|
Does Knockout of Jag1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Jag1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Jag1 (jagged 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, Sertoli cell proliferation, T cell mediated immunity, animal organ morphogenesis, aorta morphogenesis, blood vessel remodeling, camera-type eye development, cardiac neural crest cell development involved in outflow tract morphogenesis, cardiac right ventricle morphogenesis, cardiac septum morphogenesis, cell communication, cell development, ciliary body morphogenesis, distal tubule development, endocardial cushion cell development, inhibition of neuroepithelial cell differentiation, inner ear auditory receptor cell differentiation, inner ear development, loop of Henle development, morphogenesis of an epithelial sheet, morphogenesis of an epithelium, negative regulation of cell differentiation, negative regulation of cell migration, negative regulation of cell-cell adhesion, negative regulation of cell-matrix adhesion, negative regulation of endothelial cell differentiation, negative regulation of fat cell differentiation, negative regulation of neuron differentiation, negative regulation of stem cell differentiation, nephron development, neuroendocrine cell differentiation, neuronal stem cell population maintenance, podocyte development, positive regulation of Notch signaling pathway, positive regulation of cardiac epithelial to mesenchymal transition, positive regulation of cell differentiation, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of myeloid cell differentiation, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, pulmonary artery morphogenesis, pulmonary valve morphogenesis, regulation of cell population proliferation, regulation of epithelial cell proliferation, regulation of gene expression, regulation of multicellular organismal process, response to muramyl dipeptide, sensory organ morphogenesis, tube morphogenesis; MF: Notch binding, calcium ion binding, molecular adaptor activity, phospholipid binding, protein binding, receptor ligand activity; CC: adherens junction, apical part of cell, apical plasma membrane, membrane, plasma membrane
Pathways: Apelin signaling pathway - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, Notch signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TNF signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse)
UniProt: Q9QXX0
Entrez ID: 16449
|
Does Knockout of Rab15 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Rab15
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Rab15 (RAB15, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rab protein signal transduction, exocytosis, positive regulation of regulated secretory pathway, protein transport; MF: GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: cilium, cytoplasm, endomembrane system, endosome membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q3TYH2, D3YTZ8, Q3TYB1, D3YWS1, D3Z1A7, D3YYX5
Entrez ID: 104886
|
Does Knockout of Arid1b in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Arid1b
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Arid1b (AT-rich interaction domain 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, dendritic cell dendrite assembly, dendritic spine development, nervous system development, neuron-neuron synaptic transmission, positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, nucleosome binding, protein binding; CC: SWI/SNF complex, brahma complex, cytosol, nBAF complex, nucleoplasm, nucleus, plasma membrane, synapse
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: E9Q4N7
Entrez ID: 239985
|
Does Knockout of Ppp1ca in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Ppp1ca
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ppp1ca (protein phosphatase 1 catalytic subunit alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, branching morphogenesis of an epithelial tube, cell division, cell-cell adhesion, circadian regulation of gene expression, double-strand break repair via alternative nonhomologous end joining, entrainment of circadian clock by photoperiod, glycogen metabolic process, lung development, negative regulation of transcription elongation by RNA polymerase II, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of glycogen biosynthetic process, positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled, positive regulation of transcription elongation by RNA polymerase II, protein dephosphorylation, protein stabilization, regulation of circadian rhythm, regulation of glycogen biosynthetic process, regulation of glycogen catabolic process, regulation of translation, response to lead ion, rhythmic process, telomere maintenance, telomere maintenance in response to DNA damage, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity, cadherin binding involved in cell-cell adhesion, hydrolase activity, iron ion binding, metal ion binding, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein phosphatase 1 binding, protein serine/threonine phosphatase activity, protein-containing complex binding, ribonucleoprotein complex binding, transition metal ion binding; CC: PTW/PP1 phosphatase complex, adherens junction, chromosome, telomeric region, cytoplasm, cytosol, dendritic spine, glutamatergic synapse, glycogen granule, neuronal cell body, nucleolus, nucleoplasm, nucleus, perikaryon, plasma membrane, postsynapse, presynapse, protein phosphatase type 1 complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), DARPP-32 events, Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, Herpes simplex virus 1 infection - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Opioid Signalling, Oxytocin signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P62137
Entrez ID: 19045
|
Does Knockout of Hpse in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Hpse
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hpse (heparanase)
Type: protein-coding
Summary: This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: angiogenesis involved in wound healing, cell adhesion, cell-matrix adhesion, establishment of endothelial barrier, heparan sulfate proteoglycan catabolic process, heparin proteoglycan metabolic process, positive regulation of blood coagulation, positive regulation of hair follicle development, positive regulation of osteoblast proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of vascular endothelial growth factor production, protein transmembrane transport, receptor-mediated endocytosis, regulation of hair follicle development, response to antibiotic, vascular wound healing, wound healing; MF: cargo receptor ligand activity, heparanase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, syndecan binding; CC: extracellular matrix, extracellular region, extracellular space, heparanase complex, lysosomal lumen, lysosomal membrane, lysosome, membrane, membrane raft, nucleoplasm, nucleus, plasma membrane
Pathways: Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG degradation, Heparan sulfate/heparin (HS-GAG) metabolism, Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Proteoglycans in cancer - Mus musculus (mouse)
UniProt: Q6YGZ1
Entrez ID: 15442
|
Does Knockout of Pin1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Pin1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pin1 (peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, cellular response to hypoxia, negative regulation of ERK1 and ERK2 cascade, negative regulation of SMAD protein signal transduction, negative regulation of amyloid-beta formation, negative regulation of brown fat cell differentiation, negative regulation of cell motility, negative regulation of neuron apoptotic process, negative regulation of protein catabolic process, negative regulation of transforming growth factor beta receptor signaling pathway, neuron differentiation, positive regulation of canonical Wnt signaling pathway, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of neuron apoptotic process, positive regulation of transcription by RNA polymerase II, protein destabilization, protein peptidyl-prolyl isomerization, protein stabilization, protein targeting to mitochondrion, regulation of cell population proliferation, regulation of cytokinesis, regulation of gene expression, regulation of protein localization to nucleus, regulation of protein stability, regulation protein catabolic process at postsynapse, response to hypoxia, synapse organization; MF: GTPase activating protein binding, beta-catenin binding, cis-trans isomerase activity, cytoskeletal motor activity, isomerase activity, mitogen-activated protein kinase kinase binding, peptidyl-prolyl cis-trans isomerase activity, phosphoprotein binding, phosphoserine residue binding, phosphothreonine residue binding, protein binding, ubiquitin ligase activator activity; CC: cytoplasm, cytosol, glutamatergic synapse, midbody, nuclear speck, nucleoplasm, nucleus, postsynapse, postsynaptic cytosol
Pathways: DDX58/IFIH1-mediated induction of interferon-alpha/beta, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Negative regulators of DDX58/IFIH1 signaling, PI5P Regulates TP53 Acetylation, RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, RIG-I-like receptor signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional Regulation by TP53
UniProt: Q9QUR7
Entrez ID: 23988
|
Does Knockout of Psmb11 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Psmb11
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Psmb11 (proteasome (prosome, macropain) subunit, beta type, 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, alpha-beta T cell differentiation, T cell differentiation in thymus, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: endopeptidase activity, hydrolase activity, peptidase activity, protein binding, threonine-type endopeptidase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex
Pathways: Metabolism of proteins, Post-translational protein modification, Proteasome - Mus musculus (mouse), Proteasome assembly, Targeted protein degradation
UniProt: Q8BG41
Entrez ID: 73902
|
Does Knockout of Atad2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Atad2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Atad2 (ATPase family, AAA domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly, nucleosome disassembly, positive regulation of DNA-templated transcription, transcription initiation-coupled chromatin remodeling; MF: ATP binding, ATP hydrolysis activity, chromatin binding, histone binding, hydrolase activity, nucleotide binding, protein binding; CC: nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: Q8CDM1
Entrez ID: 70472
|
Does Knockout of Nkx6-3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Nkx6-3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nkx6-3 (NK6 homeobox 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell fate determination, enteroendocrine cell differentiation, glandular epithelial cell differentiation, negative regulation of stomach neuroendocrine cell differentiation, negative regulation of transcription by RNA polymerase II, neuroendocrine cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q3UHX8
Entrez ID: 74561
|
Does Knockout of Naprt in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Naprt
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Naprt (nicotinate phosphoribosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway, pyridine nucleotide biosynthetic process, response to oxidative stress; MF: ligase activity, metal ion binding, nicotinate phosphoribosyltransferase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Immune System, Innate Immune System, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Neutrophil degranulation, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nicotinate metabolism, pyridine nucleotide cycling
UniProt: Q8CC86
Entrez ID: 223646
|
Does Knockout of Mpdz in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Mpdz
|
cell proliferation
|
Regulatory T cell
|
Gene: Mpdz (multiple PDZ domain crumbs cell polarity complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, dendrite development, intracellular protein transport, myelination, tight junction assembly; CC: Schmidt-Lanterman incisure, anchoring junction, apical part of cell, apical plasma membrane, apicolateral plasma membrane, bicellular tight junction, cell projection, cytoplasm, cytoplasmic vesicle, dendrite, glutamatergic synapse, membrane, neuron projection, plasma membrane, postsynaptic density, subapical complex, synapse
Pathways: Tight junction - Mus musculus (mouse)
UniProt: Q8VBX6
Entrez ID: 17475
|
Does Knockout of Eno3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Eno3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eno3 (enolase 3, beta muscle)
Type: protein-coding
Summary: This gene encodes one of the three enolase isoenzymes found in vertebrates. Enolase is a dimeric enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate as part of the glycolytic pathway. This isozyme is found in skeletal muscle where it is involved in muscle development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: canonical glycolysis, glycolytic process; MF: identical protein binding, lyase activity, magnesium ion binding, metal ion binding, phosphopyruvate hydratase activity, protein-containing complex binding; CC: cytoplasm, cytosol, membrane, phosphopyruvate hydratase complex, plasma membrane
Pathways: Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, RNA degradation - Mus musculus (mouse), gluconeogenesis I, glycolysis I, glycolysis III, glycolysis V (Pyrococcus)
UniProt: P21550
Entrez ID: 13808
|
Does Knockout of Tepsin in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Tepsin
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Tepsin (TEPSIN, adaptor related protein complex 4 accessory protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein-containing complex binding; CC: AP-4 adaptor complex, Golgi apparatus, coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, membrane, organelle membrane, trans-Golgi network membrane
Pathways:
UniProt: Q3U3N6
Entrez ID: 78777
|
Does Knockout of Zswim1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Zswim1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Zswim1 (zinc finger SWIM-type containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q9CWV7
Entrez ID: 71971
|
Does Knockout of Gm5435 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Gm5435
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gm5435 (general transcription factor II A, 1 pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 432675
|
Does Knockout of Vkorc1l1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Vkorc1l1
|
cell cycle progression
|
breast epithelium
|
Gene: Vkorc1l1 (vitamin K epoxide reductase complex, subunit 1-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, peptidyl-glutamic acid carboxylation, vitamin K metabolic process; MF: oxidoreductase activity, quinone binding, vitamin-K-epoxide reductase (warfarin-sensitive) activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamin K, Metabolism of vitamins and cofactors, Ubiquinone and other terpenoid-quinone biosynthesis - Mus musculus (mouse)
UniProt: Q6TEK5
Entrez ID: 69568
|
Does Knockout of Trappc1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Trappc1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Trappc1 (trafficking protein particle complex 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, cytoplasm, endoplasmic reticulum
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q5NCF2
Entrez ID: 245828
|
Does Knockout of Gm5431 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Gm5431
|
cell proliferation
|
Regulatory T cell
|
Gene: Gm5431 (predicted gene 5431)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, cellular response to interferon-beta, innate immune response; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding; CC: endoplasmic reticulum membrane, membrane
Pathways: TNF signaling pathway - Mus musculus (mouse)
UniProt: Q3TMS7, A6PWD6, Q5NCB3
Entrez ID: 432555
|
Does Knockout of Qtrt2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Qtrt2
|
phagocytosis
|
macrophage
|
Gene: Qtrt2 (queuine tRNA-ribosyltransferase accessory subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA modification, tRNA processing, tRNA wobble guanine modification; MF: metal ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity, tRNA binding, tRNA-guanosine(34) queuine transglycosylase activity, zinc ion binding; CC: cytoplasm, cytoplasmic side of mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion, protein-containing complex, tRNA-guanine transglycosylase complex, transferase complex
Pathways:
UniProt: B8ZXI1
Entrez ID: 106248
|
Does Knockout of Mcts1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Mcts1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mcts1 (malignant T cell amplified sequence 1)
Type: protein-coding
Summary: Predicted to enable RNA cap binding activity; ribosomal small subunit binding activity; and translation factor activity, non-nucleic acid binding. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Human ortholog(s) of this gene implicated in immunodeficiency 118. Orthologous to human MCTS1 (MCTS1 re-initiation and release factor). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA damage response, IRES-dependent viral translational initiation, formation of translation preinitiation complex, ribosome disassembly, translation, translation reinitiation, translational initiation; MF: RNA binding, RNA cap binding, ribosomal small subunit binding, translation initiation factor activity; CC: cytoplasm
Pathways:
UniProt: Q9DB27
Entrez ID: 68995
|
Does Knockout of Lmbr1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Lmbr1
|
cell proliferation
|
Regulatory T cell
|
Gene: Lmbr1 (limb region 1)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Wnt1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Wnt1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Wnt1 (wingless-type MMTV integration site family, member 1)
Type: protein-coding
Summary: Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including astrocyte-dopaminergic neuron signaling; central nervous system development; and embryonic brain development. Acts upstream of or within several processes, including hemopoiesis; nervous system development; and regulation of protein metabolic process. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Used to study breast cancer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: BMP signaling pathway, Spemann organizer formation, T cell differentiation in thymus, Wnt signaling pathway, animal organ morphogenesis, animal organ regeneration, astrocyte-dopaminergic neuron signaling, bone development, branching involved in ureteric bud morphogenesis, canonical Wnt signaling pathway, cell fate commitment, cell proliferation in midbrain, cell-cell signaling, cellular response to peptide hormone stimulus, central nervous system morphogenesis, cerebellum development, cerebellum formation, diencephalon development, dopaminergic neuron differentiation, embryonic axis specification, embryonic brain development, forebrain anterior/posterior pattern specification, hematopoietic stem cell proliferation, hepatocyte differentiation, inner ear morphogenesis, metencephalon development, midbrain development, midbrain dopaminergic neuron differentiation, midbrain-hindbrain boundary development, midbrain-hindbrain boundary maturation during brain development, myoblast fusion, myotube differentiation, negative regulation of BMP signaling pathway, negative regulation of apoptotic process, negative regulation of cell differentiation, negative regulation of cell-cell adhesion, negative regulation of cell-substrate adhesion, negative regulation of cellular senescence, negative regulation of fat cell differentiation, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of ubiquitin-dependent protein catabolic process, neurogenesis, neuron differentiation, neuron fate commitment, neuron fate determination, positive regulation of DNA-templated transcription, positive regulation of Notch signaling pathway, positive regulation of cell population proliferation, positive regulation of dermatome development, positive regulation of fibroblast proliferation, positive regulation of hematopoietic stem cell proliferation, positive regulation of insulin-like growth factor receptor signaling pathway, positive regulation of lamellipodium assembly, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, response to wounding, signal transduction, signal transduction in response to DNA damage, spinal cord association neuron differentiation; MF: cytokine activity, frizzled binding, protein binding, protein domain specific binding, receptor ligand activity, signaling receptor binding; CC: Wnt signalosome, cell surface, cytoplasm, endoplasmic reticulum lumen, extracellular region, extracellular space
Pathways: Alzheimer disease - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Beta-catenin independent WNT signaling, Breast cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Disassembly of the destruction complex and recruitment of AXIN to the membrane, Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), PCP/CE pathway, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TCF dependent signaling in response to WNT, WNT ligand biogenesis and trafficking, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P04426
Entrez ID: 22408
|
Does Knockout of Vwa3a in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Vwa3a
|
phagocytosis
|
macrophage
|
Gene: Vwa3a (von Willebrand factor A domain containing 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UVV9
Entrez ID: 233813
|
Does Knockout of Mylk2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Mylk2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mylk2 (myosin, light polypeptide kinase 2, skeletal muscle)
Type: protein-coding
Summary: Predicted to enable myosin light chain binding activity and myosin light chain kinase activity. Involved in skeletal muscle satellite cell differentiation. Acts upstream of or within neuromuscular synaptic transmission. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to human MYLK2 (myosin light chain kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cardiac muscle cell differentiation, cardiac muscle tissue morphogenesis, neuromuscular synaptic transmission, positive regulation of fast-twitch skeletal muscle fiber contraction, positive regulation of gene expression, regulation of MAPK cascade, regulation of muscle filament sliding, regulation of neuronal synaptic plasticity, signal transduction, skeletal muscle cell differentiation, skeletal muscle satellite cell differentiation, striated muscle contraction, synaptic vesicle transport, water transport; MF: ATP binding, calmodulin binding, kinase activity, myosin light chain binding, myosin light chain kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, dendrite, dendritic spine, neuronal cell body, nucleus, synapse, synaptic vesicle, terminal bouton
Pathways: Apelin signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q8VCR8
Entrez ID: 228785
|
Does Knockout of Ccdc174 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Ccdc174
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ccdc174 (coiled-coil domain containing 174)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleoplasm, nucleus
Pathways:
UniProt: Q3U155
Entrez ID: 232236
|
Does Knockout of Aif1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Aif1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Aif1 (allograft inflammatory factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, actin crosslink formation, actin filament bundle assembly, actin filament polymerization, cellular response to oxidative stress, cellular response to type II interferon, inflammatory response, microglial cell activation, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of smooth muscle cell chemotaxis, negative regulation of smooth muscle cell proliferation, parallel actin filament bundle assembly, phagocytosis, engulfment, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of T cell migration, positive regulation of T cell proliferation, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of chemokine production, positive regulation of chemotaxis, positive regulation of fibroblast growth factor production, positive regulation of interleukin-6 production, positive regulation of monocyte chemotaxis, positive regulation of mononuclear cell migration, positive regulation of muscle hyperplasia, positive regulation of nitric oxide biosynthetic process, positive regulation of smooth muscle cell chemotaxis, positive regulation of smooth muscle cell proliferation, ruffle assembly; MF: actin binding, actin filament binding, calcium ion binding, metal ion binding, protein binding; CC: actin filament, cell projection, cytoplasm, cytoskeleton, cytosol, glial cell projection, lamellipodium, membrane, nucleus, perikaryon, perinuclear region of cytoplasm, phagocytic cup, plasma membrane, ruffle, ruffle membrane
Pathways:
UniProt: O70200
Entrez ID: 11629
|
Does Knockout of Vcl in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Vcl
|
cell cycle progression
|
breast epithelium
|
Gene: Vcl (vinculin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adherens junction assembly, apical junction assembly, axon extension, cell adhesion, epithelial cell-cell adhesion, lamellipodium assembly, morphogenesis of an epithelium, protein localization to cell surface, regulation of cell migration, regulation of establishment of endothelial barrier, regulation of focal adhesion assembly, regulation of protein localization to adherens junction; MF: actin binding, actin filament binding, alpha-catenin binding, beta-catenin binding, dystroglycan binding, molecular adaptor activity, protein binding, small GTPase binding, structural molecule activity, ubiquitin protein ligase binding; CC: Z disc, actin cytoskeleton, actin filament, adherens junction, anchoring junction, brush border, cell projection, cell-cell contact zone, cell-cell junction, costamere, cytoplasm, cytoskeleton, fascia adherens, focal adhesion, inner dense plaque of desmosome, intercalated disc, membrane, membrane raft, myofibril, outer dense plaque of desmosome, perinuclear region of cytoplasm, plasma membrane, podosome, podosome ring, protein-containing complex, sarcolemma, stress fiber, terminal web, zonula adherens
Pathways: Adherens junction - Mus musculus (mouse), Adherens junctions interactions, Amoebiasis - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Focal adhesion - Mus musculus (mouse), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Immune System, Innate Immune System, Leukocyte transendothelial migration - Mus musculus (mouse), MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Muscle contraction, Neutrophil degranulation, Platelet activation, signaling and aggregation, Platelet degranulation , RAF/MAP kinase cascade, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of actin cytoskeleton - Mus musculus (mouse), Response of endothelial cells to shear stress, Response to elevated platelet cytosolic Ca2+, Signal Transduction, Smooth Muscle Contraction, Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
UniProt: Q64727
Entrez ID: 22330
|
Does Knockout of Upf1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Upf1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Upf1 (UPF1 RNA helicase and ATPase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, DNA repair, DNA replication, cell cycle phase transition, cellular response to interleukin-1, cellular response to lipopolysaccharide, histone mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of mRNA catabolic process, positive regulation of mRNA cis splicing, via spliceosome, positive regulation of mRNA metabolic process, random inactivation of X chromosome, regulation of gene expression, regulation of telomere maintenance, regulation of translational termination, telomere maintenance via semi-conservative replication; MF: ATP binding, ATP hydrolysis activity, DNA binding, RNA binding, RNA helicase activity, chromatin binding, double-stranded DNA helicase activity, helicase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein-containing complex binding, telomeric DNA binding, zinc ion binding; CC: P-body, chromatin, chromosome, telomeric region, cytoplasm, cytosol, exon-exon junction complex, nucleoplasm, nucleus, perinuclear region of cytoplasm, supraspliceosomal complex
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9EPU0
Entrez ID: 19704
|
Does Knockout of Wfdc3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Wfdc3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Wfdc3 (WAP four-disulfide core domain 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q14AE4
Entrez ID: 71856
|
Does Knockout of Gpr34 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Gpr34
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gpr34 (G protein-coupled receptor 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled purinergic nucleotide receptor signaling pathway, G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled purinergic nucleotide receptor activity, G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q9R1K6
Entrez ID: 23890
|
Does Knockout of Pold3 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,542
|
Knockout
|
Pold3
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Pold3 (polymerase (DNA-directed), delta 3, accessory subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA synthesis involved in UV-damage excision repair, DNA-templated DNA replication, error-prone translesion synthesis, nucleotide-excision repair, DNA gap filling; MF: DNA-directed DNA polymerase activity, protein-macromolecule adaptor activity; CC: cytoplasm, delta DNA polymerase complex, nucleoplasm, nucleus, zeta DNA polymerase complex
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9EQ28
Entrez ID: 67967
|
Does Knockout of Pcf11 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Pcf11
|
response to bacteria
|
renal medulla cell line
|
Gene: Pcf11 (PCF11 cleavage and polyadenylation factor subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA 3'-end processing, mRNA processing, termination of RNA polymerase II transcription; MF: RNA polymerase II complex binding, mRNA binding; CC: cytoplasm, mRNA cleavage factor complex, mitochondrion, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, RNA polymerase II transcribes snRNA genes, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: G3X9Z4
Entrez ID: 74737
|
Does Knockout of Col11a1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Col11a1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Col11a1 (collagen, type XI, alpha 1)
Type: protein-coding
Summary: This gene encodes the alpha-1 subunit of type XI collagen, one of the low abundance fibrillar collagens that is essential for normal embryonic skeletal development and the cohesive properties of cartilage. The encoded protein, in association with the alpha-1 subunit of type II collagen, forms a heterotrimeric type XI procollagen that undergoes proteolytic processing. Mice lacking the encoded protein develop severe chondrodysplasia and die at birth. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: cartilage condensation, cartilage development, chondrocyte development, collagen fibril organization, detection of mechanical stimulus involved in sensory perception of sound, embryonic skeletal system morphogenesis, endodermal cell differentiation, heart morphogenesis, inner ear morphogenesis, proteoglycan metabolic process, sensory perception of sound, skeletal system morphogenesis, tendon development, ventricular cardiac muscle tissue morphogenesis, visual perception; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, heparan sulfate binding, heparin binding, metal ion binding; CC: collagen trimer, collagen type II trimer, collagen type XI trimer, extracellular matrix, extracellular region, extracellular space
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Extracellular matrix organization, MET activates PTK2 signaling, MET promotes cell motility, Non-integrin membrane-ECM interactions, Protein digestion and absorption - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: Q61245
Entrez ID: 12814
|
Does Knockout of 2200002J24Rik in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
2200002J24Rik
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: 2200002J24Rik (RIKEN cDNA 2200002J24 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D807
Entrez ID: 69147
|
Does Knockout of Magi1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Magi1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Magi1 (membrane associated guanylate kinase, WW and PDZ domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endothelial cell morphogenesis, positive regulation of cell-cell adhesion, signal transduction; MF: ATP binding, alpha-actinin binding, nucleotide binding, protein binding; CC: adherens junction, anchoring junction, bicellular tight junction, cell junction, cell periphery, cell projection, cell-cell junction, cytoplasm, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: Q6RHR9
Entrez ID: 14924
|
Does Knockout of Plac1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Plac1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Plac1 (placental specific protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: placenta development, spongiotrophoblast layer developmental growth; CC: extracellular region
Pathways:
UniProt: Q9JI83
Entrez ID: 56096
|
Does Knockout of Acot6 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Acot6
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Acot6 (acyl-CoA thioesterase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acyl-CoA metabolic process, fatty acid metabolic process, lipid metabolic process; MF: carboxylic ester hydrolase activity, fatty acyl-CoA hydrolase activity, hydrolase activity, thiolester hydrolase activity; CC: cytosol, peroxisome
Pathways: acyl-CoA hydrolysis
UniProt: Q32Q92
Entrez ID: 217700
|
Does Knockout of Yrdc in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Yrdc
|
phagocytosis
|
macrophage
|
Gene: Yrdc (yrdC domain containing (E.coli))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transport, regulation of translational fidelity, tRNA threonylcarbamoyladenosine modification; MF: L-threonylcarbamoyladenylate synthase, double-stranded RNA binding, nucleotidyltransferase activity, protein binding, tRNA binding, transferase activity; CC: cytoplasm, membrane, mitochondrion, plasma membrane
Pathways: Metabolism of RNA, tRNA modification in the mitochondrion, tRNA processing
UniProt: Q3U5F4
Entrez ID: 230734
|
Does Knockout of Slc27a3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Slc27a3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Slc27a3 (solute carrier family 27 (fatty acid transporter), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acyl-CoA metabolic process, fatty acid metabolic process, fatty acid transport, lipid metabolic process, lipid transport, long-chain fatty acid metabolic process, small molecule metabolic process; MF: ATP binding, arachidonate-CoA ligase activity, fatty-acyl-CoA synthase activity, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, very long-chain fatty acid-CoA ligase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, plasma membrane
Pathways: Insulin resistance - Mus musculus (mouse)
UniProt: O88561
Entrez ID: 26568
|
Does Knockout of Myh1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Myh1
|
phagocytosis
|
macrophage
|
Gene: Myh1 (myosin, heavy polypeptide 1, skeletal muscle, adult)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: muscle contraction, sensory perception of sound; MF: ATP binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding; CC: A band, cytoplasm, cytoplasmic ribonucleoprotein granule, intercalated disc, muscle myosin complex, myofibril, myosin II complex, myosin complex, myosin filament
Pathways:
UniProt: Q5SX40
Entrez ID: 17879
|
Does Knockout of Agap2 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Agap2
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Agap2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the centaurin GTPase family. This gene product regulates the activity of multiple kinases, including PI3K. Reduced expression of this gene results in multiple defects, including neural deficiencies, while increased expression of this gene has been observed in some tumors. Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: actin cytoskeleton organization, cellular response to glycine, endosomal transport, mammary gland alveolus development, negative regulation of apoptotic process, negative regulation of epithelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of neuron apoptotic process, negative regulation of protein catabolic process, phosphatidylinositol metabolic process, positive regulation of mammary gland epithelial cell proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to cell surface, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of transcription by RNA polymerase II; MF: ATP binding, GTP binding, GTPase activator activity, GTPase activity, ionotropic glutamate receptor binding, metal ion binding, nucleotide binding, phosphatidylinositol 3-kinase regulator activity, protein binding, protein kinase activator activity, protein kinase binding, protein-containing complex binding, zinc ion binding; CC: Flemming body, cytoplasm, cytosol, dendrite, endosome, external side of plasma membrane, glutamatergic synapse, membrane, nucleoplasm, nucleus, postsynapse
Pathways: Endocytosis - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), cyclic AMP biosynthesis
UniProt: Q3UHD9
Entrez ID: 216439
|
Does Knockout of B020004C17Rik in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
B020004C17Rik
|
cell proliferation
|
Melanoma Cell Line
|
Gene: B020004C17Rik (RIKEN cDNA B020004C17 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 432860
|
Does Knockout of Tcl1 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Tcl1
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Tcl1 (T cell lymphoma breakpoint 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of protein kinase B activity, intracellular signal transduction, negative regulation of gene expression, regulation of stem cell population maintenance, somatic stem cell population maintenance; MF: identical protein binding, protein kinase binding, protein serine/threonine kinase activator activity; CC: cell cortex, cytoplasm, cytosol, endoplasmic reticulum, nucleoplasm, nucleus, ooplasm, pronucleus
Pathways: PI3K-Akt signaling pathway - Mus musculus (mouse)
UniProt: P56280
Entrez ID: 21432
|
Does Knockout of Prkca in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Prkca
|
cell cycle progression
|
breast epithelium
|
Gene: Prkca (protein kinase C, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, apoptotic process, cell adhesion, cellular response to carbohydrate stimulus, central nervous system neuron axonogenesis, chondrocyte differentiation, desmosome assembly, induction of positive chemotaxis, intracellular calcium ion homeostasis, intracellular signal transduction, intrinsic apoptotic signaling pathway, learning or memory, muscle cell cellular homeostasis, negative regulation of D-glucose import, negative regulation of D-glucose transmembrane transport, negative regulation of MAPK cascade, negative regulation of cell population proliferation, negative regulation of cytokine production involved in inflammatory response, negative regulation of glial cell apoptotic process, negative regulation of insulin receptor signaling pathway, negative regulation of translation, neutrophil chemotaxis, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of ERK1 and ERK2 cascade, positive regulation of angiogenesis, positive regulation of angiotensin-activated signaling pathway, positive regulation of blood vessel endothelial cell migration, positive regulation of bone resorption, positive regulation of cardiac muscle hypertrophy, positive regulation of cell adhesion, positive regulation of cell migration, positive regulation of cytokine production involved in inflammatory response, positive regulation of dense core granule biogenesis, positive regulation of developmental process, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of exocytosis, positive regulation of inflammatory response, positive regulation of lipopolysaccharide-mediated signaling pathway, positive regulation of macrophage differentiation, positive regulation of mitotic cell cycle, positive regulation of multicellular organismal process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of signal transduction, positive regulation of smooth muscle cell proliferation, positive regulation of synapse assembly, presynaptic modulation of chemical synaptic transmission, proteasome-mediated ubiquitin-dependent protein catabolic process, protein kinase C signaling, protein phosphorylation, regulation of muscle contraction, regulation of platelet aggregation, regulation of synaptic vesicle exocytosis, regulation of the force of heart contraction, renal sodium ion absorption, response to estradiol, response to ethanol, response to interleukin-1, response to phorbol 13-acetate 12-myristate, response to reactive oxygen species, signal transduction involved in regulation of gene expression, stem cell differentiation; MF: ATP binding, calcium,diacylglycerol-dependent serine/threonine kinase activity, diacylglycerol-dependent serine/threonine kinase activity, enzyme binding, histone H3T6 kinase activity, integrin binding, kinase activity, lipid binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, signaling receptor binding, transferase activity, zinc ion binding; CC: alphav-beta3 integrin-PKCalpha complex, apical part of cell, axon, calyx of Held, ciliary basal body, cone photoreceptor outer segment, cytoplasm, cytosol, dendrite, endoplasmic reticulum, intercalated disc, membrane, mitochondrial membrane, mitochondrion, neuronal cell body, nucleus, ooplasm, perinuclear region of cytoplasm, plasma membrane, presynaptic cytosol, protein-containing complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Acetylcholine regulates insulin secretion, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), African trypanosomiasis - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), Beta-catenin independent WNT signaling, Ca-dependent events, CaM pathway, Calcium signaling pathway - Mus musculus (mouse), Calmodulin induced events, Cell Cycle, Cell Cycle, Mitotic, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), DAG and IP3 signaling, Depolymerization of the Nuclear Lamina, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Disinhibition of SNARE formation, Dopaminergic synapse - Mus musculus (mouse), EGFR Transactivation by Gastrin, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Extracellular matrix organization, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), G alpha (i) signalling events, G alpha (q) signalling events, G-protein mediated events, GABAergic synapse - Mus musculus (mouse), GPCR downstream signalling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Gastrin-CREB signalling pathway via PKC and MAPK, Glioma - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Glutamatergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), HuR (ELAVL1) binds and stabilizes mRNA, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Intracellular signaling by second messengers, Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), M Phase, MAPK signaling pathway - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Metabolism, Metabolism of RNA, MicroRNAs in cancer - Mus musculus (mouse), Mitotic Prophase, Morphine addiction - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neutrophil extracellular trap formation - Mus musculus (mouse), Non-integrin membrane-ECM interactions, Non-small cell lung cancer - Mus musculus (mouse), Nuclear Envelope Breakdown, Opioid Signalling, Oxytocin signaling pathway - Mus musculus (mouse), PCP/CE pathway, PI3K-Akt signaling pathway - Mus musculus (mouse), PLC beta mediated events, Pancreatic secretion - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation, signaling and aggregation, Proteoglycans in cancer - Mus musculus (mouse), RET signaling, RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of KIT signaling, Regulation of insulin secretion, Regulation of mRNA stability by proteins that bind AU-rich elements, Relaxin signaling pathway - Mus musculus (mouse), Response to elevated platelet cytosolic Ca2+, Retrograde endocannabinoid signaling - Mus musculus (mouse), SHC1 events in ERBB2 signaling, Salivary secretion - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by ERBB2, Signaling by GPCR, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by VEGF, Signaling by WNT, Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Syndecan interactions, Thyroid hormone signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses, VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated cell proliferation, Vascular smooth muscle contraction - Mus musculus (mouse), WNT5A-dependent internalization of FZD4, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P20444
Entrez ID: 18750
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Does Knockout of Ubb in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
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Knockout
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Ubb
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cell proliferation
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Pre-B-Lymphocyte Cell Line
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Gene: Ubb (ubiquitin B)
Type: protein-coding
Summary: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: adipose tissue development, energy homeostasis, fat pad development, female gonad development, female meiosis I, hypothalamus gonadotrophin-releasing hormone neuron development, male gonad development, male meiosis I, mitochondrion transport along microtubule, modification-dependent protein catabolic process, neuron projection morphogenesis, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of protein monoubiquitination, positive regulation of protein ubiquitination, protein ubiquitination, regulation of mitochondrial membrane potential, regulation of neuron apoptotic process, regulation of proteasomal protein catabolic process, seminiferous tubule development; MF: protein binding, protein tag activity, structural constituent of ribosome, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, membrane, mitochondrial outer membrane, mitochondrion, myelin sheath, neuron projection, neuronal cell body, nucleoplasm, nucleus
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activated NOTCH1 Transmits Signal to the Nucleus, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Aerobic respiration and respiratory electron transport, Aggrephagy, Alpha-protein kinase 1 signaling pathway, Antigen processing: Ubiquitination & Proteasome degradation, Asparagine N-linked glycosylation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Autophagy, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Calnexin/calreticulin cycle, Cargo recognition for clathrin-mediated endocytosis, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell death signalling via NRAGE, NRIF and NADE, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Clathrin-mediated endocytosis, Co-inhibition by PD-1, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, Deactivation of the beta-catenin transactivating complex, Death Receptor Signaling, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Downregulation of ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, Downregulation of ERBB4 signaling, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Downregulation of TGF-beta receptor signaling, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, EGFR downregulation, ER Quality Control Compartment (ERQC), Endosomal Sorting Complex Required For Transport (ESCRT), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, FLT3 Signaling, Fanconi Anemia Pathway, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, G1 Phase, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Homology Directed Repair, IKK complex recruitment mediated by RIP1, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, IRAK2 mediated activation of TAK1 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, Immune System, Inactivation of CSF3 (G-CSF) signaling, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Ion channel transport, Iron uptake and transport, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), M Phase, MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Macroautophagy, Membrane Trafficking, Metabolism, Metabolism of RNA, Metabolism of proteins, Metalloprotease DUBs, Mitophagy, Mitophagy - animal - Mus musculus (mouse), Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, NF-kB is activated and signals survival, NIK-->noncanonical NF-kB signaling, NOD1/2 Signaling Pathway, NOTCH3 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Neddylation, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of FLT3, Negative regulation of MAPK pathway, Negative regulation of MET activity, Negative regulators of DDX58/IFIH1 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oncogene Induced Senescence, Orc1 removal from chromatin, Ovarian tumor domain proteases, Oxidative Stress Induced Senescence, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PD-L1(CD274) glycosylation and translocation to plasma membrane, PINK1-PRKN Mediated Mitophagy, PIP3 activates AKT signaling, PTEN Regulation, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Peroxisomal protein import, Pexophagy, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Post-translational protein modification, Processing of DNA double-strand break ends, Programmed Cell Death, Protein localization, Protein ubiquitination, Pyruvate metabolism, RAF/MAP kinase cascade, RAS processing, RIPK1-mediated regulated necrosis, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Recognition of DNA damage by PCNA-containing replication complex, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulated Necrosis, Regulation of APC/C activators between G1/S and early anaphase, Regulation of BACH1 activity, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of FZD by ubiquitination, Regulation of Homotypic Cell-Cell Adhesion, Regulation of NF-kappa B signaling, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PLK1 Activity at G2/M Transition, Regulation of PTEN localization, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TNFR1 signaling, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of expression of SLITs and ROBOs, Regulation of innate immune responses to cytosolic DNA, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of necroptotic cell death, Regulation of pyruvate metabolism, Regulation of signaling by CBL, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, SPOP-mediated proteasomal degradation of PD-L1(CD274), Selective autophagy, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Hedgehog, Signaling by Interleukins, Signaling by MET, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH3, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spry regulation of FGF signaling, Stabilization of p53, Stimuli-sensing channels, Switching of origins to a post-replicative state, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, TAK1-dependent IKK and NF-kappa-B activation , TCF dependent signaling in response to WNT, TCR signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , Termination of translesion DNA synthesis, The role of GTSE1 in G2/M progression after G2 checkpoint, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Mus musculus (mouse), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, VLDLR internalisation and degradation, Vesicle-mediated transport, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, activated TAK1 mediates p38 MAPK activation, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, p75 NTR receptor-mediated signalling, p75NTR recruits signalling complexes, p75NTR signals via NF-kB
UniProt: P0CG49
Entrez ID: 22187
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