prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ostm1 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Ostm1 | cell proliferation | Embryonic Stem Cell Line | Gene: Ostm1 (osteopetrosis associated transmembrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: osteoclast differentiation, transepithelial chloride transport; CC: chloride channel complex, cytosol, lysosomal membrane, lysosome, membrane
Pathways: ... |
Does Knockout of Col9a2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Col9a2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Col9a2 (collagen, type IX, alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: extracellular matrix structural constituent conferring tensile strength, protein homodimerization activity; CC: collagen trimer, collagen type IX trimer, extracellular matrix, extrac... |
Does Knockout of Taf2 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 1 | 1,716 | Knockout | Taf2 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Taf2 (TATA-box binding protein associated factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, RNA polymerase II preinitiation complex assembly, mRNA transcription by RNA polymerase II, positive regulation of DNA-templated... |
Does Knockout of Grk6 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,684 | Knockout | Grk6 | protein/peptide distribution | myoblast cell line | Gene: Grk6 (G protein-coupled receptor kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, desensitization of G protein-coupled receptor signaling pathway, regulation of signal transduction, signal transduction; MF: ATP binding, G protein-coup... |
Does Knockout of Acbd7 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Acbd7 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Acbd7 (acyl-Coenzyme A binding domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, energy homeostasis, fatty acid metabolic process, gene expression, leptin-mediated signaling pathway, response to food; ... |
Does Knockout of Arl9 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Arl9 | cell viability | Immortal mouse chromaffin cells | Gene: Arl9 (ADP-ribosylation factor-like 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, GTPase activity, molecular_function, nucleotide binding
Pathways:
UniProt:
Entrez ID: 384185 |
Does Knockout of Trim75 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Trim75 | cell proliferation | Embryonic Stem Cell Line | Gene: Trim75 (tripartite motif-containing 75)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: female meiosis I, innate immune response, regulation of gene expression; MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytoskeleton, ... |
Does Knockout of Nfxl1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Nfxl1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Nfxl1 (nuclear transcription factor, X-box binding-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, DNA-binding transcr... |
Does Knockout of Snai2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Snai2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Snai2 (snail family zinc finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, cartilage morphogenesis, cell migration involved in endocardial cushion formation, cellular response to epidermal growth factor stimulus, cellular response to... |
Does Knockout of Nmu in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Nmu | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Nmu (neuromedin U)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: eating behavior, energy homeostasis, gastric acid secretion, negative regulation of eating behavior, negative regulation of feeding behavior, negative regulation of gastric acid secretion, negative r... |
Does Knockout of Pdcd5 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Pdcd5 | cell proliferation | Mouse kidney carcinoma cell | Gene: Pdcd5 (programmed cell death 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to transforming growth factor beta stimulus, negative regulation of protein folding, positive regulation of apoptotic process, positive regulation of... |
Does Knockout of Zfp551 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Zfp551 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Zfp551 (zinc finger protein 551)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor act... |
Does Knockout of Rab35 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Rab35 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Rab35 (RAB35, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rab protein signal transduction, antigen processing and presentation, cellular response to nerve growth factor stimulus, endocytic recycling, endosomal transport, intracellular... |
Does Knockout of Pcyox1l in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Pcyox1l | protein/peptide accumulation | Mouse cell | Gene: Pcyox1l (prenylcysteine oxidase 1 like)
Type: protein-coding
Summary: Predicted to enable prenylcysteine oxidase activity. Involved in neutrophil-mediated killing of bacterium. Predicted to be located in extracellular region. Orthologous to human PCYOX1L (prenylcysteine oxidase 1 like). [provided ... |
Does Knockout of Chrng in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Chrng | protein/peptide distribution | myoblast cell line | Gene: Chrng (cholinergic receptor, nicotinic, gamma polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine receptor signaling pathway, chemical synaptic transmission, excitatory postsynaptic potential, membrane depolarization, monoatomic cation transpo... |
Does Knockout of Gja10 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Gja10 | response to chemicals | pro-B-lymphocyte | Gene: Gja10 (gap junction protein, alpha 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, cell-cell signaling, detection of light stimulus involved in visual perception, gamete generation, response to light stimulus, synapse assembly, transmembrane ... |
Does Knockout of Tmem127 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,275 | Knockout | Tmem127 | cell proliferation | Colonic Cancer Cell Line | Gene: Tmem127 (transmembrane protein 127)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome organization, negative regulation of TOR signaling, negative regulation of cell population proliferation, regulation of TOR signaling; MF: small GTPase binding; CC: cytoplas... |
Does Knockout of Lrg1 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Lrg1 | cell proliferation | Regulatory T cell | Gene: Lrg1 (leucine-rich alpha-2-glycoprotein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brown fat cell differentiation, keratinocyte migration, leukocyte adhesion to vascular endothelial cell, positive regulation of angiogenesis, positive regulation of endothelia... |
Does Knockout of Polr2m in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 83 | Knockout | Polr2m | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Polr2m (polymerase (RNA) II (DNA directed) polypeptide M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of ER location, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, molecular_function, transcription elongation f... |
Does Knockout of Gm21835 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Gm21835 | phagocytosis | macrophage | Gene: Gm21835 (predicted gene, 21835)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Zfp524 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Zfp524 | protein/peptide distribution | myoblast cell line | Gene: Zfp524 (zinc finger protein 524)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA b... |
Does Knockout of Tnks2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 165 | Knockout | Tnks2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Tnks2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)
Type: protein-coding
Summary: Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Acts upstream of or within regulation of growth. ... |
Does Knockout of Ythdf2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Ythdf2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Ythdf2 (YTH N6-methyladenosine RNA binding protein 2)
Type: protein-coding
Summary: Enables N6-methyladenosine-containing RNA reader activity. Involved in several processes, including hematopoietic stem cell proliferation; negative regulation of gene expression; and spermatogonial cell division. L... |
Does Knockout of Nsmce3 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Nsmce3 | response to virus | Embryonic Fibroblast Cell Line | Gene: Nsmce3 (NSE3 homolog, SMC5-SMC6 complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cellular response to UV, cellular response to hydroxyurea, cellular response to radiation, negative regulation of t... |
Does Knockout of Ppp3r2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Ppp3r2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Ppp3r2 (protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcineurin-mediated signaling, negative regulation of calcium ion import across plasma membrane, penetration of zona pelluci... |
Does Knockout of Cd177 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Cd177 | cell proliferation | Colonic Cancer Cell Line | Gene: Cd177 (CD177 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, cell-cell junction maintenance, immune system process, innate immune response, leukocyte cell-cell adhesion, neutrophil ex... |
Does Knockout of Kank2 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Kank2 | cell cycle progression | breast epithelium | Gene: Kank2 (KN motif and ankyrin repeat domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, kidney epithelium development, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of actin filament polymerization, negati... |
Does Knockout of Naa30 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Naa30 | response to virus | Embryonic Fibroblast Cell Line | Gene: Naa30 (N(alpha)-acetyltransferase 30, NatC catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization; MF: acyltransferase activity, acyltransferase activity, transferri... |
Does Knockout of Bysl in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Bysl | cell proliferation | Melanoma Cell Line | Gene: Bysl (bystin-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, in utero embryonic development, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis, stem cell prolife... |
Does Knockout of Polk in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Polk | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Polk (polymerase (DNA directed), kappa)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, cellular response to UV, error-prone translesion synthesis, nucleotide-excision repair, DNA gap fillin... |
Does Knockout of Gm13090 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Gm13090 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Gm13090 (predicted gene 13090)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 105704528 |
Does Knockout of Gm16253 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Gm16253 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Gm16253 (predicted gene 16253)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Alg2 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Alg2 | phagocytosis | macrophage | Gene: Alg2 (ALG2 alpha-1,3/1,6-mannosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferas... |
Does Knockout of Eepd1 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Eepd1 | phagocytosis | macrophage | Gene: Eepd1 (endonuclease/exonuclease/phosphatase family domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, positive regulation of cholesterol efflux; MF: DNA binding, catalytic activity; CC: plasma membrane
Pathways:
UniPr... |
Does Knockout of Trim72 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Trim72 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Trim72 (tripartite motif-containing 72)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, innate immune response, muscle organ development, muscle system process, negative regulation of insulin receptor signaling pathway, negative regulation of insulin-lik... |
Does Knockout of Gpr174 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 1 | 2,174 | Knockout | Gpr174 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Gpr174 (G protein-coupled receptor 174)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, T cell homeostasis, adenylate cyclase-activating G protein-coupled receptor signaling pathway, negative regulation of interleukin-2 ... |
Does Knockout of Hcst in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Hcst | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Hcst (hematopoietic cell signal transducer)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: natural killer cell mediated cytotoxicity, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of immune response; MF: phosp... |
Does Knockout of Sgce in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Sgce | cell proliferation | Melanoma Cell Line | Gene: Sgce (sarcoglycan, epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, cell projection, cytoplasm, cytoskeleton, dendrite, dendrite membrane, dystrophin-associated glycoprotein complex, membrane, plasma membrane, sarcoglycan complex, sarcolemma... |
Does Knockout of Pif1 in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,539 | Knockout | Pif1 | response to chemicals | Lymphoma Cell Line | Gene: Pif1 (PIF1 5'-to-3' DNA helicase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, negative regulation of telomere maintenance via telomerase, protein-DNA-RNA complex disassembly, telomere maintenance; MF: 5'-3' DNA... |
Does Knockout of Atp6v1b1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Atp6v1b1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Atp6v1b1 (ATPase, H+ transporting, lysosomal V1 subunit B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, adult behavior, calcium ion homeostasis, chloride ion homeostasis, inner ear morphogenesis, monoatomic ion transport, olfactory behavio... |
Does Knockout of Slc5a3 in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Slc5a3 | response to bacteria | macrophage | Gene: Slc5a3 (solute carrier family 5 (inositol transporters), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate transmembrane transport, hexose transmembrane transport, inositol metabolic process, monoatomic ion transport, myo-inositol transport, per... |
Does Knockout of Trip4 in cardiac muscle cell line causally result in protein/peptide accumulation? | 0 | 1,662 | Knockout | Trip4 | protein/peptide accumulation | cardiac muscle cell line | Gene: Trip4 (thyroid hormone receptor interactor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen receptor signaling pathway, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of myoblast differentiation, ... |
Does Knockout of Serpinf1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Serpinf1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Serpinf1 (serine (or cysteine) peptidase inhibitor, clade F, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to cobalt ion, cellular response to dexamethasone stimulus, cellular response to glucose stimulus, cellular response to retinoic ... |
Does Knockout of Spef2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Spef2 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Spef2 (sperm flagellar 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain morphogenesis, cell differentiation, cerebrospinal fluid circulation, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, mucocili... |
Does Knockout of Rassf1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Rassf1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Rassf1 (Ras association (RalGDS/AF-6) domain family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, Ras protein signal transduction, positive regulation of protein ubiquitination, protein stabilization, regulation of cell cycle, regula... |
Does Knockout of Asphd2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Asphd2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Asphd2 (aspartate beta-hydroxylase domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: dioxygenase activity, metal ion binding, molecular_function, oxidoreductase activity
Pathways:
UniProt: Q80VP9
Entrez ID: 72898 |
Does Knockout of Rrm1 in Microglial Cell Line causally result in response to virus? | 1 | 1,908 | Knockout | Rrm1 | response to virus | Microglial Cell Line | Gene: Rrm1 (ribonucleotide reductase M1)
Type: protein-coding
Summary: Enables disordered domain specific binding activity; purine nucleotide binding activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in several processes, including nucleoside phosph... |
Does Knockout of Zwint in Immortal mouse chromaffin cells causally result in cell viability? | 1 | 2,469 | Knockout | Zwint | cell viability | Immortal mouse chromaffin cells | Gene: Zwint (ZW10 interactor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, establishment of localization in cell, homologous chromosome orientation in meiotic metaphase I, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signalin... |
Does Knockout of Cdc45 in Lymphoma Cell Line causally result in response to chemicals? | 1 | 1,551 | Knockout | Cdc45 | response to chemicals | Lymphoma Cell Line | Gene: Cdc45 (cell division cycle 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication initiation, double-strand break repair via break-induced replication, mitotic DNA replication preinitiation complex assembly; MF: DNA replication origin b... |
Does Knockout of Ptch1 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Ptch1 | response to chemicals | pro-B-lymphocyte | Gene: Ptch1 (patched 1)
Type: protein-coding
Summary: Enables cyclin binding activity; heparin binding activity; and patched binding activity. Involved in several processes, including cellular response to cholesterol; chordate embryonic development; and regulation of DNA-templated transcription. Acts up... |
Does Knockout of Sorbs1 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Sorbs1 | protein/peptide accumulation | Microglial Cell Line | Gene: Sorbs1 (sorbin and SH3 domain containing 1)
Type: protein-coding
Summary: Enables enzyme binding activity; insulin receptor binding activity; and signaling receptor complex adaptor activity. Involved in several processes, including focal adhesion assembly; insulin receptor signaling pathway; and p... |
Does Knockout of Cyp27b1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Cyp27b1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Cyp27b1 (cytochrome P450, family 27, subfamily b, polypeptide 1)
Type: protein-coding
Summary: Enables calcidiol 1-monooxygenase activity. Involved in calcitriol biosynthetic process from calciol; response to vitamin D; and vitamin D catabolic process. Acts upstream of or within calcium ion transp... |
Does Knockout of Myh13 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Myh13 | cell proliferation | Melanoma Cell Line | Gene: Myh13 (myosin, heavy polypeptide 13, skeletal muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to starvation, muscle contraction; MF: ATP binding, actin binding, actin filament binding, cytoskeletal motor activity, microfilament motor activi... |
Does Knockout of Fmo5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Fmo5 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Fmo5 (flavin containing monooxygenase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, regulation of cholesterol metabolic process, xenobiotic metabolic process; MF: N,N-dimethylaniline monooxygenase activity, NAD(P)H oxidase H2O2-forming ... |
Does Knockout of Stoml2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Stoml2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Stoml2 (stomatin (Epb7.2)-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD4-positive, alpha-beta T cell activation, T cell receptor signaling pathway, intracellular calcium ion homeostasis, lipid localization, mitochondrial protein processing, mitochondrio... |
Does Knockout of Jag1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Jag1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Jag1 (jagged 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, Sertoli cell proliferation, T cell mediated immunity, animal organ morphogenesis, aorta morphogenesis, blood vessel remodeling, camera-type eye development, cardiac neural crest... |
Does Knockout of Rab15 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Rab15 | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Rab15 (RAB15, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rab protein signal transduction, exocytosis, positive regulation of regulated secretory pathway, protein transport; MF: GTP binding, GTPase activity, hydrolase activity, metal ... |
Does Knockout of Arid1b in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Arid1b | protein/peptide accumulation | Embryonic Cell Line | Gene: Arid1b (AT-rich interaction domain 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, dendritic cell dendrite assembly, dendritic spine development, nervous system development, neuron-neuron synaptic transmission, posit... |
Does Knockout of Ppp1ca in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Ppp1ca | cell proliferation | Mouse kidney carcinoma cell | Gene: Ppp1ca (protein phosphatase 1 catalytic subunit alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, branching morphogenesis of an epithelial tube, cell division, cell-cell adhesion, circadian regulation of gene expression, do... |
Does Knockout of Hpse in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Hpse | cell proliferation | Mouse kidney carcinoma cell | Gene: Hpse (heparanase)
Type: protein-coding
Summary: This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteo... |
Does Knockout of Pin1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Pin1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Pin1 (peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, cellular response to hypoxia, negative regulation of ERK1 and ERK2 cascade, negative regulation of SMAD protein signal tra... |
Does Knockout of Psmb11 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,177 | Knockout | Psmb11 | tumorigenicity | Colonic Cancer Cell Line | Gene: Psmb11 (proteasome (prosome, macropain) subunit, beta type, 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, alpha-beta T cell differentiation, T cell differentiation in thymus, proteasome-mediated ubiquitin-dependent protein catabolic process, prot... |
Does Knockout of Atad2 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,178 | Knockout | Atad2 | tumorigenicity | Colonic Cancer Cell Line | Gene: Atad2 (ATPase family, AAA domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly, nucleosome disassembly, positive regulation of DNA-templated transcription, transcription initiation-coupled chromatin remodeling; MF: ATP binding, AT... |
Does Knockout of Nkx6-3 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Nkx6-3 | protein/peptide accumulation | Embryonic Cell Line | Gene: Nkx6-3 (NK6 homeobox 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell fate determination, enteroendocrine cell differentiation, glandular epithelial cell differentiation, negative regulation of stomach neuroendocrine cell differentiation... |
Does Knockout of Naprt in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Naprt | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Naprt (nicotinate phosphoribosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway, pyridine nucleotide biosynthetic process, response to oxidative stress; MF: ligase activity, me... |
Does Knockout of Mpdz in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Mpdz | cell proliferation | Regulatory T cell | Gene: Mpdz (multiple PDZ domain crumbs cell polarity complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, dendrite development, intracellular protein transport, myelination, tight junction assembly; CC: Schmidt-Lanterman incisure, anchoring ju... |
Does Knockout of Eno3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Eno3 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Eno3 (enolase 3, beta muscle)
Type: protein-coding
Summary: This gene encodes one of the three enolase isoenzymes found in vertebrates. Enolase is a dimeric enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate as part of the glycolytic pathway. This isozyme is found in skeletal muscle wh... |
Does Knockout of Tepsin in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Tepsin | cell viability | Immortal mouse chromaffin cells | Gene: Tepsin (TEPSIN, adaptor related protein complex 4 accessory protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein-containing complex binding; CC: AP-4 adaptor complex, Golgi apparatus, coated vesicle membrane, cytoplasm, cytoplasmic ve... |
Does Knockout of Zswim1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Zswim1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Zswim1 (zinc finger SWIM-type containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q9CWV7
Entrez ID: 71971 |
Does Knockout of Gm5435 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Gm5435 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Gm5435 (general transcription factor II A, 1 pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 432675 |
Does Knockout of Vkorc1l1 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Vkorc1l1 | cell cycle progression | breast epithelium | Gene: Vkorc1l1 (vitamin K epoxide reductase complex, subunit 1-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, peptidyl-glutamic acid carboxylation, vitamin K metabolic process; MF: oxidoreductase activity, quinone binding, v... |
Does Knockout of Trappc1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Trappc1 | protein/peptide distribution | myoblast cell line | Gene: Trappc1 (trafficking protein particle complex 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TR... |
Does Knockout of Gm5431 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Gm5431 | cell proliferation | Regulatory T cell | Gene: Gm5431 (predicted gene 5431)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, cellular response to interferon-beta, innate immune response; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding; CC: endoplasmic reticulum mem... |
Does Knockout of Qtrt2 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Qtrt2 | phagocytosis | macrophage | Gene: Qtrt2 (queuine tRNA-ribosyltransferase accessory subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA modification, tRNA processing, tRNA wobble guanine modification; MF: metal ion binding, protein binding, protein heterodimerization activity, protein hom... |
Does Knockout of Mcts1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Mcts1 | cell proliferation | Melanoma Cell Line | Gene: Mcts1 (malignant T cell amplified sequence 1)
Type: protein-coding
Summary: Predicted to enable RNA cap binding activity; ribosomal small subunit binding activity; and translation factor activity, non-nucleic acid binding. Predicted to be involved in IRES-dependent viral translational initiation; ... |
Does Knockout of Lmbr1 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Lmbr1 | cell proliferation | Regulatory T cell | Gene: Lmbr1 (limb region 1)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Wnt1 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Wnt1 | protein/peptide accumulation | Regulatory T cell | Gene: Wnt1 (wingless-type MMTV integration site family, member 1)
Type: protein-coding
Summary: Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including astrocyte-dopaminergic neuron signaling; central nervous system development; and embryonic brai... |
Does Knockout of Vwa3a in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Vwa3a | phagocytosis | macrophage | Gene: Vwa3a (von Willebrand factor A domain containing 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UVV9
Entrez ID: 233813 |
Does Knockout of Mylk2 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Mylk2 | protein/peptide accumulation | Embryonic Cell Line | Gene: Mylk2 (myosin, light polypeptide kinase 2, skeletal muscle)
Type: protein-coding
Summary: Predicted to enable myosin light chain binding activity and myosin light chain kinase activity. Involved in skeletal muscle satellite cell differentiation. Acts upstream of or within neuromuscular synaptic tr... |
Does Knockout of Ccdc174 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Ccdc174 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Ccdc174 (coiled-coil domain containing 174)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleoplasm, nucleus
Pathways:
UniProt: Q3U155
Entrez ID: 232236 |
Does Knockout of Aif1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Aif1 | cell proliferation | Melanoma Cell Line | Gene: Aif1 (allograft inflammatory factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, actin crosslink formation, actin filament bundle assembly, actin filament polymerization, cellular response to oxidative stress, cellular response... |
Does Knockout of Vcl in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Vcl | cell cycle progression | breast epithelium | Gene: Vcl (vinculin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adherens junction assembly, apical junction assembly, axon extension, cell adhesion, epithelial cell-cell adhesion, lamellipodium assembly, morphogenesis of an epithelium, protein localization to cell su... |
Does Knockout of Upf1 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 579 | Knockout | Upf1 | cell proliferation | Embryonic Stem Cell Line | Gene: Upf1 (UPF1 RNA helicase and ATPase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, DNA repair, DNA replication, cell cycle phase transition, cellular response to interleukin-1, cellular response to lipopolysaccharide, histone m... |
Does Knockout of Wfdc3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Wfdc3 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Wfdc3 (WAP four-disulfide core domain 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular s... |
Does Knockout of Gpr34 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Gpr34 | cell proliferation | Mouse kidney carcinoma cell | Gene: Gpr34 (G protein-coupled receptor 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled purinergic nucleotide receptor signaling pathway, G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled purinergic nucleotide r... |
Does Knockout of Pold3 in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,542 | Knockout | Pold3 | response to chemicals | Lymphoma Cell Line | Gene: Pold3 (polymerase (DNA-directed), delta 3, accessory subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA synthesis involved in UV-... |
Does Knockout of Pcf11 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Pcf11 | response to bacteria | renal medulla cell line | Gene: Pcf11 (PCF11 cleavage and polyadenylation factor subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA 3'-end processing, mRNA processing, termination of RNA polymerase II transcription; MF: RNA polymerase II complex binding, mRNA binding; CC: cytoplasm, mRN... |
Does Knockout of Col11a1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Col11a1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Col11a1 (collagen, type XI, alpha 1)
Type: protein-coding
Summary: This gene encodes the alpha-1 subunit of type XI collagen, one of the low abundance fibrillar collagens that is essential for normal embryonic skeletal development and the cohesive properties of cartilage. The encoded protein, in a... |
Does Knockout of 2200002J24Rik in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | 2200002J24Rik | cell proliferation | Embryonic Fibroblast Cell Line | Gene: 2200002J24Rik (RIKEN cDNA 2200002J24 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D807
Entrez ID: 69147 |
Does Knockout of Magi1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Magi1 | protein/peptide distribution | myoblast cell line | Gene: Magi1 (membrane associated guanylate kinase, WW and PDZ domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endothelial cell morphogenesis, positive regulation of cell-cell adhesion, signal transduction; MF: ATP binding, alpha-actinin binding, nucle... |
Does Knockout of Plac1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Plac1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Plac1 (placental specific protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: placenta development, spongiotrophoblast layer developmental growth; CC: extracellular region
Pathways:
UniProt: Q9JI83
Entrez ID: 56096 |
Does Knockout of Acot6 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Acot6 | protein/peptide accumulation | Mouse cell | Gene: Acot6 (acyl-CoA thioesterase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acyl-CoA metabolic process, fatty acid metabolic process, lipid metabolic process; MF: carboxylic ester hydrolase activity, fatty acyl-CoA hydrolase activity, hydrolase activity, thioles... |
Does Knockout of Yrdc in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Yrdc | phagocytosis | macrophage | Gene: Yrdc (yrdC domain containing (E.coli))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transport, regulation of translational fidelity, tRNA threonylcarbamoyladenosine modification; MF: L-threonylcarbamoyladenylate synthase, double-stranded RN... |
Does Knockout of Slc27a3 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Slc27a3 | protein/peptide accumulation | Embryonic Cell Line | Gene: Slc27a3 (solute carrier family 27 (fatty acid transporter), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acyl-CoA metabolic process, fatty acid metabolic process, fatty acid transport, lipid metabolic process, lipid transport, long-chain fatty acid meta... |
Does Knockout of Myh1 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Myh1 | phagocytosis | macrophage | Gene: Myh1 (myosin, heavy polypeptide 1, skeletal muscle, adult)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: muscle contraction, sensory perception of sound; MF: ATP binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, micro... |
Does Knockout of Agap2 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Agap2 | response to chemicals | pro-B-lymphocyte | Gene: Agap2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the centaurin GTPase family. This gene product regulates the activity of multiple kinases, including PI3K. Reduced expression of this gene results in mult... |
Does Knockout of B020004C17Rik in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | B020004C17Rik | cell proliferation | Melanoma Cell Line | Gene: B020004C17Rik (RIKEN cDNA B020004C17 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 432860 |
Does Knockout of Tcl1 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Tcl1 | response to virus | Neuroblastoma Cell Line | Gene: Tcl1 (T cell lymphoma breakpoint 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of protein kinase B activity, intracellular signal transduction, negative regulation of gene expression, regulation of stem cell population maintenance, somatic stem cell ... |
Does Knockout of Prkca in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Prkca | cell cycle progression | breast epithelium | Gene: Prkca (protein kinase C, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, apoptotic process, cell adhesion, cellular response to carbohydrate stimulus, central nervous system neuron axonogenesis, chondrocyte differentiation, desmosome assembly, i... |
Does Knockout of Ubb in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 81 | Knockout | Ubb | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Ubb (ubiquitin B)
Type: protein-coding
Summary: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of g... |
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