prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Scrib in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Scrib
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Scrib (scribbled planar cell polarity)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of GTPase activity, apoptotic process involved in morphogenesis, astrocyte cell migration, auditory receptor cell morphogenesis, auditory receptor cell stereocilium organization, camera-type eye morphogenesis, cell differentiation, cell migration, cell population proliferation, cell-cell adhesion, cochlear nucleus development, epithelial cell morphogenesis, epithelial structure maintenance, establishment of T cell polarity, establishment of apical/basal cell polarity, establishment of cell polarity, establishment or maintenance of apical/basal cell polarity, establishment or maintenance of epithelial cell apical/basal polarity, inner ear receptor cell stereocilium organization, intracellular protein localization, mammary gland duct morphogenesis, morphogenesis of embryonic epithelium, negative regulation of activated T cell proliferation, negative regulation of mitotic cell cycle, negative regulation of translational initiation, neural tube closure, neurotransmitter receptor transport, endosome to postsynaptic membrane, polarized epithelial cell differentiation, positive chemotaxis, positive regulation of apoptotic process, positive regulation of epithelial cell migration, positive regulation of epithelial to mesenchymal transition, positive regulation of receptor recycling, positive regulation of type II interferon production, post-anal tail morphogenesis, protein localization to adherens junction, receptor clustering, regulation of postsynaptic neurotransmitter receptor internalization, synaptic vesicle endocytosis, synaptic vesicle targeting, vesicle-mediated transport in synapse, wound healing; MF: protein binding, protein kinase binding, signaling adaptor activity; CC: Scrib-APC-beta-catenin complex, adherens junction, anchoring junction, apical plasma membrane, basolateral plasma membrane, cell junction, cell leading edge, cell projection, cell-cell contact zone, cell-cell junction, cytoplasm, cytosol, extrinsic component of postsynaptic density membrane, glutamatergic synapse, immunological synapse, lamellipodium, membrane, myelin sheath abaxonal region, nucleoplasm, plasma membrane, postsynapse, postsynaptic density, postsynaptic membrane, presynapse, presynaptic membrane, synapse
Pathways: Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), RHO GTPase cycle, RHOQ GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q80U72
Entrez ID: 105782
|
Does Knockout of Tmem126b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Tmem126b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmem126b (transmembrane protein 126B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly, mitochondrion organization, response to food; CC: membrane, mitochondrial membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport
UniProt: Q9D1R1
Entrez ID: 68472
|
Does Knockout of Tmem114 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Tmem114
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmem114 (transmembrane protein 114)
Type: protein-coding
Summary: Located in apical plasma membrane and apicolateral plasma membrane. Is expressed in several structures, including gut; heart; liver; male reproductive gland or organ; and metanephros. Orthologous to human TMEM114 (transmembrane protein 114). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: anchoring junction, apical plasma membrane, apicolateral plasma membrane, bicellular tight junction, lateral plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q9D563
Entrez ID: 74720
|
Does Knockout of Usp36 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 578
|
Knockout
|
Usp36
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Usp36 (ubiquitin specific peptidase 36)
Type: protein-coding
Summary: Predicted to enable K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and histone H2B deubiquitinase activity. Involved in several processes, including nucleolus organization; protein stabilization; and regulation of rRNA processing. Predicted to be located in cytoplasm; nuclear speck; and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human USP36 (ubiquitin specific peptidase 36). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of macroautophagy, nucleolus organization, protein deubiquitination, protein stabilization, proteolysis, regulation of apoptotic process, regulation of protein stability, regulation of rRNA processing; MF: K48-linked deubiquitinase activity, RNA binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2B deubiquitinase activity, hydrolase activity, peptidase activity, transferase activity; CC: cytoplasm, cytosol, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: B1AQJ2
Entrez ID: 72344
|
Does Knockout of Smoc2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Smoc2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Smoc2 (SPARC related modular calcium binding 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extracellular matrix organization, positive regulation of DNA biosynthetic process, positive regulation of angiogenesis, positive regulation of cell-substrate adhesion, positive regulation of endothelial cell chemotaxis, positive regulation of endothelial cell migration, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of mitotic cell cycle, positive regulation of vascular endothelial growth factor signaling pathway, positive regulation of vascular wound healing; MF: calcium ion binding, extracellular matrix binding, glycosaminoglycan binding, heparin binding, metal ion binding; CC: basement membrane, cell periphery, extracellular matrix, extracellular region, extracellular space, interstitial matrix
Pathways:
UniProt: Q8CD91
Entrez ID: 64074
|
Does Knockout of Rxfp3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Rxfp3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Rxfp3 (relaxin family peptide receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of cytokinesis, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, galanin receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Relaxin receptors, Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q8BGE9
Entrez ID: 239336
|
Does Knockout of Abhd5 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Abhd5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Abhd5 (abhydrolase domain containing 5)
Type: protein-coding
Summary: Enables lipase activator activity. Involved in negative regulation of triglyceride storage and positive regulation of triglyceride catabolic process. Located in cytosol and lipid droplet. Is expressed in central nervous system; dorsal root ganglion; heart; retina; and skin. Used to study Chanarin-Dorfman syndrome. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to human ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell differentiation, fatty acid metabolic process, lipid homeostasis, lipid metabolic process, negative regulation of triglyceride storage, phosphatidic acid biosynthetic process, phospholipid biosynthetic process, positive regulation of lipid catabolic process, positive regulation of triglyceride catabolic process; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, acyltransferase activity, carboxylic ester hydrolase activity, lipase activator activity, lysophosphatidic acid acyltransferase activity, protein binding, transferase activity, triacylglycerol lipase activity; CC: cytoplasm, cytosol, lipid droplet, nucleoplasm
Pathways: Regulation of lipolysis in adipocytes - Mus musculus (mouse)
UniProt: Q9DBL9
Entrez ID: 67469
|
Does Knockout of Cadm4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Cadm4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cadm4 (cell adhesion molecule 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of peptidyl-threonine phosphorylation, negative regulation of peptidyl-tyrosine phosphorylation, negative regulation of protein phosphorylation, negative regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of vascular endothelial growth factor signaling pathway, regulation of Rac protein signal transduction, regulation of cell motility, regulation of cell population proliferation, regulation of protein phosphorylation, regulation of wound healing, synaptic membrane adhesion; MF: protein phosphatase binding, receptor tyrosine kinase binding, vascular endothelial growth factor receptor 1 binding, vascular endothelial growth factor receptor 2 binding; CC: cell leading edge, cell-cell contact zone, membrane, synaptic membrane
Pathways:
UniProt: Q8R464
Entrez ID: 260299
|
Does Knockout of Rhox9 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Rhox9
|
phagocytosis
|
macrophage
|
Gene: Rhox9 (reproductive homeobox 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: A4FTZ4, Q9EQM5
Entrez ID: 104384
|
Does Knockout of Mpz in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 2,187
|
Knockout
|
Mpz
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Mpz (myelin protein zero)
Type: protein-coding
Summary: This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: cell aggregation, cell-cell adhesion via plasma-membrane adhesion molecules, cell-cell junction maintenance, myelination, negative regulation of apoptotic process; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: Cell adhesion molecules - Mus musculus (mouse)
UniProt: P27573
Entrez ID: 17528
|
Does Knockout of B3gnt9 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
B3gnt9
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: B3gnt9 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: poly-N-acetyllactosamine biosynthetic process, protein O-linked glycosylation, protein glycosylation; MF: UDP-glycosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification
UniProt: Q8VI16
Entrez ID: 97440
|
Does Knockout of Ddt in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Ddt
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ddt (D-dopachrome tautomerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: melanin biosynthetic process, positive regulation of inflammatory response; MF: D-dopachrome decarboxylase activity, cytokine receptor binding, lyase activity, phenylpyruvate tautomerase activity, protease binding; CC: cytoplasm, extracellular space
Pathways:
UniProt: O35215
Entrez ID: 13202
|
Does Knockout of Trim54 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Trim54
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trim54 (tripartite motif-containing 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, innate immune response, negative regulation of microtubule depolymerization; MF: metal ion binding, microtubule binding, protein binding, ubiquitin protein ligase activity, zinc ion binding; CC: Z disc, cytoplasm, cytoskeleton, microtubule, microtubule associated complex
Pathways:
UniProt: Q9ERP3
Entrez ID: 58522
|
Does Knockout of Cd3e in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Cd3e
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cd3e (CD3 antigen, epsilon polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell costimulation, T cell receptor signaling pathway, adaptive immune response, apoptotic signaling pathway, cell surface receptor signaling pathway, cerebellum development, dendrite development, immune system process, lymphocyte activation, negative regulation of gene expression, negative regulation of smoothened signaling pathway, negative thymic T cell selection, positive regulation of CD4-positive, alpha-beta T cell proliferation, positive regulation of MAPK cascade, positive regulation of T cell activation, positive regulation of T cell anergy, positive regulation of T cell proliferation, positive regulation of calcium-mediated signaling, positive regulation of cell-cell adhesion mediated by integrin, positive regulation of cell-matrix adhesion, positive regulation of gene expression, positive regulation of interleukin-2 production, positive regulation of interleukin-4 production, positive regulation of type II interferon production, positive thymic T cell selection, regulation of signal transduction, response to nutrient; MF: SH3 domain binding, identical protein binding, protein binding, transmembrane signaling receptor activity; CC: Golgi apparatus, T cell receptor complex, alpha-beta T cell receptor complex, cell body, cell-cell junction, dendritic spine, endoplasmic reticulum, external side of plasma membrane, immunological synapse, membrane, plasma membrane
Pathways: Adaptive Immune System, Chagas disease - Mus musculus (mouse), Co-inhibition by PD-1, Downstream TCR signaling, Epstein-Barr virus infection - Mus musculus (mouse), Generation of second messenger molecules, Hematopoietic cell lineage - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Measles - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Phosphorylation of CD3 and TCR zeta chains, Primary immunodeficiency - Mus musculus (mouse), Regulation of T cell activation by CD28 family, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Translocation of ZAP-70 to Immunological synapse
UniProt: P22646
Entrez ID: 12501
|
Does Knockout of Mtif2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Mtif2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mtif2 (mitochondrial translational initiation factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translational initiation, ribosome disassembly, translation, translational initiation; MF: GTP binding, GTPase activity, nucleotide binding, ribosomal small subunit binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, intracellular organelle lumen, mitochondrion, nucleoplasm
Pathways:
UniProt: Q91YJ5
Entrez ID: 76784
|
Does Knockout of Twnk in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Twnk
|
cell proliferation
|
Regulatory T cell
|
Gene: Twnk (twinkle mtDNA helicase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, mitochondrial DNA replication, mitochondrial transcription, protein hexamerization; MF: 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA helicase activity, helicase activity, hydrolase activity, identical protein binding, isomerase activity, lipid binding, nucleotide binding, protease binding, single-stranded DNA binding; CC: membrane, mitochondrial chromosome, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrion
Pathways: DNA Replication, Metabolism of proteins, Mitochondrial protein degradation, Spinocerebellar ataxia - Mus musculus (mouse), Strand-asynchronous mitochondrial DNA replication
UniProt: Q8CIW5
Entrez ID: 226153
|
Does Knockout of Zfr2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Zfr2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfr2 (zinc finger RNA binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: double-stranded RNA binding, molecular_function, nucleic acid binding, single-stranded RNA binding, zinc ion binding
Pathways:
UniProt: F6VRB4, E9Q5M4, D3YXQ2
Entrez ID: 103406
|
Does Knockout of Epyc in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Epyc
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Epyc (epiphycan)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: articular cartilage development, bone development, sensory perception of sound; CC: extracellular matrix, extracellular region
Pathways:
UniProt: P70186
Entrez ID: 13516
|
Does Knockout of Lgalsl in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Lgalsl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lgalsl (galectin like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, molecular_function
Pathways:
UniProt: Q8VED9
Entrez ID: 216551
|
Does Knockout of Sfxn5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Sfxn5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sfxn5 (sideroflexin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, citrate transport, mitochondrial transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of cold-induced thermogenesis, transmembrane transport; MF: citrate transmembrane transporter activity, monoatomic ion transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q925N0
Entrez ID: 94282
|
Does Knockout of Sec62 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Sec62
|
cell cycle progression
|
breast epithelium
|
Gene: Sec62 (SEC62 homolog, preprotein translocation)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: post-translational protein targeting to endoplasmic reticulum membrane, post-translational protein targeting to membrane, translocation, protein transport; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Protein export - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q8BU14
Entrez ID: 69276
|
Does Knockout of Slc4a2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Slc4a2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Slc4a2 (solute carrier family 4 (anion exchanger), member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amelogenesis, bicarbonate transport, cell differentiation, chloride transmembrane transport, chloride transport, monoatomic anion transmembrane transport, monoatomic anion transport, monoatomic ion transport, negative regulation of CD8-positive, alpha-beta T cell differentiation, negative regulation of CD8-positive, alpha-beta T cell proliferation, osteoclast differentiation, positive regulation of enamel mineralization, regulation of actin cytoskeleton organization, regulation of bone resorption, regulation of intracellular pH, spermatogenesis, transmembrane transport; MF: antiporter activity, chloride transmembrane transporter activity, chloride:bicarbonate antiporter activity, enzyme binding, monoatomic anion transmembrane transporter activity, solute:inorganic anion antiporter activity, transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane
Pathways: Bicarbonate transporters, Bile secretion - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Salivary secretion - Mus musculus (mouse), Transport of small molecules
UniProt: P13808
Entrez ID: 20535
|
Does Knockout of Ruvbl1 in Lung Cancer Cell Line causally result in tumorigenicity?
| 1
| 1,089
|
Knockout
|
Ruvbl1
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Ruvbl1 (RuvB-like AAA ATPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, box C/D snoRNP assembly, cell division, chromatin organization, chromatin remodeling, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of canonical Wnt signaling pathway, positive regulation of double-strand break repair via homologous recombination, positive regulation of telomere maintenance in response to DNA damage, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of chromosome organization, regulation of double-strand break repair, regulation of embryonic development, regulation of transcription by RNA polymerase II, telomere maintenance; MF: 3'-5' DNA helicase activity, ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATPase binding, DNA helicase activity, TBP-class protein binding, TFIID-class transcription factor complex binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, transcription coactivator activity; CC: Ino80 complex, MLL1 complex, NuA4 histone acetyltransferase complex, R2TP complex, RPAP3/R2TP/prefoldin-like complex, Swr1 complex, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, dynein axonemal particle, membrane, nuclear matrix, nuclear speck, nucleoplasm, nucleosome, nucleus, protein folding chaperone complex, protein-containing complex, ribonucleoprotein complex
Pathways: Cell Cycle, Chromosome Maintenance, DNA Damage Recognition in GG-NER, DNA Repair, Deposition of new CENPA-containing nucleosomes at the centromere, Deubiquitination, Formation of the beta-catenin:TCF transactivating complex, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleosome assembly, Nucleotide Excision Repair, Post-translational protein modification, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, UCH proteinases, Ub-specific processing proteases, Wnt signaling pathway - Mus musculus (mouse)
UniProt: P60122
Entrez ID: 56505
|
Does Knockout of Atp8b5 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Atp8b5
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Atp8b5 (ATPase, class I, type 8B, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, lipid transport, phospholipid translocation, phospholipid transport; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, magnesium ion binding, metal ion binding, nucleotide binding, phosphatidylcholine flippase activity, phosphatidylethanolamine flippase activity; CC: acrosomal membrane, acrosomal vesicle, cytoplasm, cytoplasmic vesicle, endomembrane system, membrane, plasma membrane, trans-Golgi network
Pathways:
UniProt: A3FIN4
Entrez ID: 320571
|
Does Knockout of 2310022B05Rik in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
2310022B05Rik
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: 2310022B05Rik (RIKEN cDNA 2310022B05 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol
Pathways:
UniProt: Q8C3W1
Entrez ID: 69551
|
Does Knockout of Apol10b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Apol10b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Apol10b (apolipoprotein L 10B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lipid transport, lipoprotein metabolic process; MF: chloride channel activity, lipid binding, molecular_function; CC: extracellular region, extracellular space, high-density lipoprotein particle, membrane, very-low-density lipoprotein particle
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Scavenging of heme from plasma, Vesicle-mediated transport
UniProt: G3X9K7, Q8BZS1
Entrez ID: 328561
|
Does Knockout of Cdh1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Cdh1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cdh1 (cadherin 1)
Type: protein-coding
Summary: This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: actin cytoskeleton organization, adherens junction organization, bicellular tight junction assembly, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell junction assembly, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, cellular response to amino acid stimulus, cellular response to indole-3-methanol, cellular response to lithium ion, cochlea development, decidualization, desmosome assembly, embryo implantation, epithelial cell morphogenesis, establishment of skin barrier, homophilic cell adhesion via plasma membrane adhesion molecules, in utero embryonic development, intestinal epithelial cell development, negative regulation of axon extension, negative regulation of canonical Wnt signaling pathway, negative regulation of cell migration, negative regulation of cell-cell adhesion, negative regulation of epithelial cell proliferation, negative regulation of protein localization to plasma membrane, negative regulation of protein processing, positive regulation of DNA-templated transcription, positive regulation of cell-cell adhesion, positive regulation of protein import into nucleus, positive regulation of protein localization, protein localization to plasma membrane, regulation of branching involved in salivary gland morphogenesis, regulation of gene expression, regulation of neuron migration, regulation of protein catabolic process at postsynapse, modulating synaptic transmission, regulation of protein localization, regulation of protein localization to cell surface, salivary gland cavitation, sensory perception of sound, synapse assembly, trophectodermal cell differentiation, uterine epithelium development; MF: GTPase activating protein binding, alpha-catenin binding, ankyrin binding, beta-catenin binding, cadherin binding, calcium ion binding, cell adhesion molecule binding, cell-cell adhesion mediator activity, cytoskeletal protein binding, gamma-catenin binding, identical protein binding, metal ion binding, molecular adaptor activity, protein binding, protein domain specific binding, protein phosphatase binding, protein tyrosine kinase binding; CC: Golgi apparatus, Schmidt-Lanterman incisure, actin cytoskeleton, adherens junction, anchoring junction, apical junction complex, apical part of cell, axon, axon terminus, basolateral plasma membrane, catenin complex, cell junction, cell periphery, cell surface, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytoplasmic side of plasma membrane, desmosome, endosome, flotillin complex, glutamatergic synapse, lamellipodium, lateral loop, lateral plasma membrane, membrane, microvillus, node of Ranvier, perinuclear region of cytoplasm, plasma membrane, postsynapse, trans-Golgi network
Pathways: Adherens junction - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Endometrial cancer - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse)
UniProt: P09803
Entrez ID: 12550
|
Does Knockout of 2310009B15Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
2310009B15Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: 2310009B15Rik (RIKEN cDNA 2310009B15 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A0A6YWI4, D3Z1T2
Entrez ID: 69549
|
Does Knockout of Stab2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Stab2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Stab2 (stabilin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, defense response to Gram-positive bacterium, defense response to bacterium, endocytosis, hyaluronan catabolic process, receptor-mediated endocytosis; MF: calcium ion binding, cargo receptor activity, hyaluronic acid binding, low-density lipoprotein particle binding, low-density lipoprotein particle receptor activity, scavenger receptor activity; CC: cytoplasm, cytosol, external side of plasma membrane, membrane, plasma membrane
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Glycosaminoglycan metabolism, Hyaluronan degradation, Hyaluronan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Scavenging by Class H Receptors, Vesicle-mediated transport
UniProt: Q8R4U0
Entrez ID: 192188
|
Does Knockout of Zfp960 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Zfp960
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp960 (zinc finger protein 960)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: Q3ULR3, L7N267
Entrez ID: 449000
|
Does Knockout of Tsku in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Tsku
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tsku (tsukushi, small leucine rich proteoglycan)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, anterior commissure morphogenesis, camera-type eye development, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, ciliary body morphogenesis, corpus callosum morphogenesis, energy homeostasis, hippocampus development, inner ear receptor cell stereocilium organization, lateral ventricle development, negative regulation of Wnt signaling pathway, negative regulation of myofibroblast differentiation, negative regulation of neuron projection development, negative regulation of transforming growth factor beta1 production, nervous system development, positive regulation of hair cycle, regulation of gene expression, wound healing; MF: cytokine binding, protein binding, signaling receptor activity, transforming growth factor beta binding; CC: extracellular region, extracellular space, plasma membrane
Pathways:
UniProt: Q8CBR6
Entrez ID: 244152
|
Does Knockout of Fgf17 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Fgf17
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Fgf17 (fibroblast growth factor 17)
Type: protein-coding
Summary: Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including arterial system; central nervous system; embryo mesenchyme; nose; and skeleton. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 20 with or without anosmia. Orthologous to human FGF17 (fibroblast growth factor 17). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: fibroblast growth factor receptor signaling pathway, neurogenesis, positive regulation of MAPK cascade, positive regulation of cell population proliferation, regulation of cell migration; MF: growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, FGFR1 ligand binding and activation, FGFR1c ligand binding and activation, FGFR2 ligand binding and activation, FGFR2c ligand binding and activation, FGFR3 ligand binding and activation, FGFR3b ligand binding and activation, FGFR3c ligand binding and activation, FGFR4 ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Gastric cancer - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, Phospholipase C-mediated cascade; FGFR3, Phospholipase C-mediated cascade; FGFR4, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: P63075
Entrez ID: 14171
|
Does Knockout of Adam5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Adam5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adam5 (a disintegrin and metallopeptidase domain 5)
Type: protein-coding
Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016].
Gene Ontology: BP: binding of sperm to zona pellucida, cell adhesion, male gonad development, proteolysis; MF: metalloendopeptidase activity, metallopeptidase activity, protein binding; CC: cell surface, membrane, plasma membrane
Pathways:
UniProt: Q3TTE0
Entrez ID: 11499
|
Does Knockout of Arpc5 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Arpc5
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Arpc5 (actin related protein 2/3 complex, subunit 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin filament network formation, cell migration, lamellipodium organization, maintenance of cell polarity, microtubule organizing center localization, regulation of actin filament polymerization, smooth muscle cell migration; MF: actin binding, actin filament binding, protein-macromolecule adaptor activity, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cytoskeleton, cell projection, cortical cytoskeleton, cytoplasm, cytoskeleton, endosome, glutamatergic synapse, growth cone, lamellipodium, nucleus, postsynaptic density, site of double-strand break
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, Neutrophil degranulation, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: Q9CPW4
Entrez ID: 67771
|
Does Knockout of Clca2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Clca2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Clca2 (chloride channel accessory 2)
Type: protein-coding
Summary: This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. Mice lacking a functional copy of this gene exhibit increased liver weight and hepatocyte hypertrophy. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: cell adhesion, chloride transmembrane transport, chloride transport, monoatomic ion transmembrane transport, monoatomic ion transport, proteolysis; MF: chloride channel activity, hydrolase activity, intracellularly calcium-gated chloride channel activity, ligand-gated monoatomic ion channel activity, metal ion binding, metallopeptidase activity, peptidase activity; CC: anchoring junction, basal plasma membrane, cell junction, cytosol, membrane, nuclear membrane, nucleoplasm, plasma membrane
Pathways: Ion channel transport, Pancreatic secretion - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Stimuli-sensing channels, Transport of small molecules
UniProt: Q8BG22
Entrez ID: 229933
|
Does Knockout of Dkkl1 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Dkkl1
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Dkkl1 (dickkopf-like 1)
Type: protein-coding
Summary: Predicted to enable co-receptor binding activity and receptor antagonist activity. Involved in negative regulation of testosterone biosynthetic process; penetration of zona pellucida; and positive regulation of apoptotic process. Acts upstream of or within canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Located in acrosomal vesicle. Is expressed in several structures, including dorsal root ganglion; extraembryonic component; reproductive system; and sensory organ. Orthologous to human DKKL1 (dickkopf like acrosomal protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: canonical Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of testosterone biosynthetic process, penetration of zona pellucida, positive regulation of apoptotic process, positive regulation of fat cell differentiation; MF: co-receptor binding, protein binding, receptor antagonist activity; CC: acrosomal vesicle, cytoplasmic vesicle, extracellular region, extracellular space
Pathways:
UniProt: Q9QZL9
Entrez ID: 50722
|
Does Knockout of Far2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Far2
|
cell proliferation
|
Regulatory T cell
|
Gene: Far2 (fatty acyl CoA reductase 2)
Type: protein-coding
Summary: Enables alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to act upstream of or within wax biosynthetic process. Located in peroxisome. Is expressed in alveolar sulcus; anterior naris; brain; ovary; and skin. Used to study alopecia and dry eye syndrome. Orthologous to human FAR2 (fatty acyl-CoA reductase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lipid metabolic process, long-chain fatty-acyl-CoA metabolic process, wax biosynthetic process; MF: alcohol-forming long-chain fatty acyl-CoA reductase activity, alcohol-forming very long-chain fatty acyl-CoA reductase activity, oxidoreductase activity; CC: membrane, peroxisomal membrane, peroxisome
Pathways: Metabolism, Metabolism of lipids, Peroxisome - Mus musculus (mouse), Wax and plasmalogen biosynthesis, Wax biosynthesis
UniProt: Q7TNT2
Entrez ID: 330450
|
Does Knockout of Apbb1ip in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Apbb1ip
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Apbb1ip (amyloid beta precursor protein binding family B member 1 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, positive regulation of cell adhesion, signal transduction; CC: T cell receptor complex, anchoring junction, cell projection, cytoplasm, cytoskeleton, cytosol, focal adhesion, lamellipodium, membrane, plasma membrane
Pathways: GRB2:SOS provides linkage to MAPK signaling for Integrins , Hemostasis, Integrin signaling, MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Platelet Aggregation (Plug Formation), Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Signal Transduction, p130Cas linkage to MAPK signaling for integrins
UniProt: Q8R5A3
Entrez ID: 54519
|
Does Knockout of Grin2b in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Grin2b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Grin2b (glutamate receptor, ionotropic, NMDA2B (epsilon 2))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, associative learning, behavioral fear response, behavioral response to pain, calcium ion transmembrane import into cytosol, calcium ion transport, calcium-mediated signaling, chemical synaptic transmission, detection of mechanical stimulus involved in sensory perception of pain, excitatory postsynaptic potential, fear response, in utero embryonic development, intracellular calcium ion homeostasis, ionotropic glutamate receptor signaling pathway, learning, learning or memory, long-term synaptic potentiation, memory, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of dendritic spine maintenance, neuromuscular process, positive regulation of excitatory postsynaptic potential, positive regulation of glutamate secretion, positive regulation of inhibitory postsynaptic potential, positive regulation of synaptic transmission, positive regulation of synaptic transmission, glutamatergic, protein heterotetramerization, receptor clustering, regulation of ARF protein signal transduction, regulation of MAPK cascade, regulation of cAMP/PKA signal transduction, regulation of long-term neuronal synaptic plasticity, regulation of long-term synaptic depression, regulation of monoatomic cation transmembrane transport, regulation of neuronal synaptic plasticity, regulation of postsynaptic membrane potential, regulation of synaptic plasticity, response to ethanol, response to hypoxia, response to mechanical stimulus, rhythmic process, sensitization, sensory organ development, startle response, suckling behavior, synaptic transmission, glutamatergic; MF: D2 dopamine receptor binding, NMDA glutamate receptor activity, beta-catenin binding, calcium channel activity, cell adhesion molecule binding, extracellularly glutamate-gated ion channel activity, glutamate binding, glutamate receptor binding, glutamate-gated calcium ion channel activity, glutamate-gated receptor activity, glycine binding, heterocyclic compound binding, interleukin-1 receptor binding, ionotropic glutamate receptor binding, ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, metal ion binding, monoatomic cation channel activity, monoatomic ion channel activity, protein binding, protein serine/threonine kinase binding, protein tyrosine kinase binding, protein-containing complex binding, scaffold protein binding, signaling receptor activity, signaling receptor binding, small molecule binding, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential, zinc ion binding; CC: NMDA selective glutamate receptor complex, Z disc, apical dendrite, cell projection, cell surface, cytoplasm, cytoskeleton, dendrite, dendritic branch, dendritic spine, endoplasmic reticulum membrane, endosome, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, late endosome, lysosome, membrane, neuron projection, neuronal cell body, parallel fiber to Purkinje cell synapse, plasma membrane, postsynapse, postsynaptic density, postsynaptic density membrane, postsynaptic density, intracellular component, postsynaptic membrane, presynaptic active zone membrane, presynaptic membrane, synapse, synaptic cleft, synaptic membrane, synaptic vesicle, terminal bouton, transport vesicle membrane
Pathways: Activation of NMDA receptors and postsynaptic events, Alcoholism - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Assembly and cell surface presentation of NMDA receptors, Axon guidance, Circadian entrainment - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Developmental Biology, Dopaminergic synapse - Mus musculus (mouse), EPH-Ephrin signaling, EPHB-mediated forward signaling, Glutamatergic synapse - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Nervous system development, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein-protein interactions at synapses, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Signal Transduction, Spinocerebellar ataxia - Mus musculus (mouse), Synaptic adhesion-like molecules, Systemic lupus erythematosus - Mus musculus (mouse), Transmission across Chemical Synapses, Unblocking of NMDA receptors, glutamate binding and activation, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q01097
Entrez ID: 14812
|
Does Knockout of Snx10 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Snx10
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Snx10 (sorting nexin 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization involved in bone maturation, bone remodeling, bone resorption, calcium ion homeostasis, cell projection organization, cellular homeostasis, cellular response to leukemia inhibitory factor, cilium assembly, endocytosis, endosome organization, establishment of localization in cell, gastric acid secretion, intracellular protein transport, osteoclast differentiation, protein localization to centrosome, protein localization to cilium, protein transport, ruffle assembly, tooth eruption, vesicle organization; MF: 1-phosphatidylinositol binding, ATPase binding, lipid binding, phosphatidylinositol binding, phosphatidylinositol phosphate binding; CC: apical cytoplasm, centrosome, cytoplasm, cytoskeleton, endoplasmic reticulum, endosome, endosome membrane, extrinsic component of endosome membrane, membrane, nucleus, secretory granule
Pathways:
UniProt: Q9CWT3
Entrez ID: 71982
|
Does Knockout of Cdk17 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Cdk17
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cdk17 (cyclin dependent kinase 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8K0D0
Entrez ID: 237459
|
Does Knockout of Umodl1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Umodl1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Umodl1 (uromodulin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, cellular response to gonadotropin-releasing hormone, ectopic germ cell programmed cell death, regulation of apoptotic process, regulation of developmental process, regulation of gene expression, regulation of granulosa cell apoptotic process, regulation of ovarian follicle development, single fertilization; MF: calcium ion binding, peptidase inhibitor activity; CC: cell periphery, cell surface, external side of plasma membrane, extracellular region, extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q5DID3
Entrez ID: 52020
|
Does Knockout of Cib2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Cib2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cib2 (calcium and integrin binding family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion homeostasis, cellular response to ATP, photoreceptor cell maintenance, positive regulation of cytosolic calcium ion concentration; MF: calcium ion binding, integrin binding, magnesium ion binding, metal ion binding, protein binding, protein homodimerization activity, protein-containing complex binding; CC: cell periphery, cell projection, cuticular plate, cytoplasm, cytosol, membrane, muscle tendon junction, neuromuscular junction, photoreceptor inner segment, photoreceptor outer segment, plasma membrane, sarcolemma, stereocilium
Pathways:
UniProt: Q9Z309
Entrez ID: 56506
|
Does Knockout of Mrps35 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Mrps35
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mrps35 (mitochondrial ribosomal protein S35)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: cytosol, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q8BJZ4
Entrez ID: 232536
|
Does Knockout of Rgs13 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Rgs13
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rgs13 (regulator of G-protein signaling 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, negative regulation of G protein-coupled receptor signaling pathway, negative regulation of signal transduction; CC: cytosol, nucleus, plasma membrane
Pathways: G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q8K443
Entrez ID: 246709
|
Does Knockout of Nudt2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Nudt2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nudt2 (nudix hydrolase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMP biosynthetic process, ATP biosynthetic process, apoptotic process; MF: GTP binding, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity, bis(5'-nucleosyl)-tetraphosphatase activity, hydrolase activity, nucleotide binding
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse)
UniProt: P56380
Entrez ID: 66401
|
Does Knockout of Zbtb34 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Zbtb34
|
cell cycle progression
|
breast epithelium
|
Gene: Zbtb34 (zinc finger and BTB domain containing 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: A2ATY4
Entrez ID: 241311
|
Does Knockout of Ncapd2 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Ncapd2
|
phagocytosis
|
macrophage
|
Gene: Ncapd2 (non-SMC condensin I complex, subunit D2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromosome condensation, meiotic chromosome condensation, mitotic cell cycle, mitotic chromosome condensation, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation; MF: histone binding; CC: centriolar satellite, chromosome, ciliary basal body, condensed chromosome, condensed chromosome, centromeric region, condensed nuclear chromosome, condensin complex, cytoplasm, cytosol, nuclear chromosome, nucleoplasm, nucleus, pronucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Condensation of Prometaphase Chromosomes, M Phase, Mitotic Prometaphase
UniProt: Q8K2Z4
Entrez ID: 68298
|
Does Knockout of T in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
T
|
cell proliferation
|
Melanoma Cell Line
|
Gene: T (brachyury, T-box transcription factor T)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, anterior/posterior pattern specification, bone morphogenesis, cardiac muscle cell differentiation, cardiac muscle cell myoblast differentiation, cell fate specification, cellular response to retinoic acid, determination of heart left/right asymmetry, embryonic skeletal system development, heart morphogenesis, mesoderm development, mesoderm formation, mesoderm migration involved in gastrulation, negative regulation of transcription by RNA polymerase II, neural plate morphogenesis, neural tube closure, notochord development, notochord formation, penetration of zona pellucida, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, post-anal tail morphogenesis, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, signal transduction involved in regulation of gene expression, somitogenesis, vasculogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription corepressor activity; CC: chromatin, cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: P20293
Entrez ID: 20997
|
Does Knockout of Arsb in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Arsb
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Arsb (arylsulfatase B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior head development, autophagy, chondroitin sulfate proteoglycan catabolic process, colon epithelial cell migration, dermatan sulfate proteoglycan catabolic process, positive regulation of neuron projection development, regulation of epithelial cell migration, response to estrogen, response to methylmercury, response to nutrient, response to pH; MF: N-acetylgalactosamine-4-sulfatase activity, N-acetylgalactosamine-6-sulfatase activity, arylsulfatase activity, hydrolase activity, metal ion binding, sulfuric ester hydrolase activity; CC: cell surface, lysosome
Pathways: CS/DS degradation, Chondroitin sulfate/dermatan sulfate metabolism, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Immune System, Innate Immune System, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of lipids, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, Sphingolipid metabolism, The activation of arylsulfatases, chondroitin sulfate degradation (metazoa)
UniProt: P50429
Entrez ID: 11881
|
Does Knockout of Clic1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Clic1
|
cell cycle progression
|
breast epithelium
|
Gene: Clic1 (chloride intracellular channel 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, chloride transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of osteoblast differentiation, regulation of mitochondrial membrane potential; MF: chloride channel activity, oxidoreductase activity; CC: chloride channel complex, cytoplasm, endoplasmic reticulum, extracellular exosome, membrane, mitochondrial membrane, mitochondrion, monoatomic ion channel complex, nuclear envelope, nuclear membrane, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q9Z1Q5
Entrez ID: 114584
|
Does Knockout of Gast in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Gast
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Gast (gastrin)
Type: protein-coding
Summary: This gene encodes the peptide hormone gastrin, which stimulates gastric acid secretion, proliferation, cell migration and angiogenesis, as well as inhibits apoptosis. The encoded preproprotein undergoes proteolytic processing to generate multiple gastrin peptides differing in size. Mice lacking the encoded protein exhibit a decrease in the number of parietal cells, achlorohydria and a decrease in the colonic proliferation. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to food; MF: hormone activity, protein binding; CC: extracellular region, extracellular space
Pathways: G alpha (q) signalling events, GPCR downstream signalling, Gastric acid secretion - Mus musculus (mouse), Gastrin-CREB signalling pathway via PKC and MAPK, Signal Transduction, Signaling by GPCR
UniProt: P48757
Entrez ID: 14459
|
Does Knockout of Magee2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Magee2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Magee2 (MAGE family member E2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, brain morphogenesis, negative regulation of transcription by RNA polymerase II
Pathways:
UniProt: Q8CBC3, Q52KG3
Entrez ID: 272790
|
Does Knockout of Myo1c in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Myo1c
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Myo1c (myosin IC)
Type: protein-coding
Summary: This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin filament organization, actin filament-based movement, cellular response to type II interferon, chromatin remodeling, endocytosis, positive regulation of actin filament polymerization, positive regulation of cell migration, positive regulation of cellular response to insulin stimulus, positive regulation of protein targeting to membrane, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, protein targeting to membrane, regulation of bicellular tight junction assembly, vascular endothelial growth factor signaling pathway, vesicle transport along actin filament; MF: ATP binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding, phospholipid binding, protein binding, signaling receptor binding, small GTPase binding; CC: B-WICH complex, actin cytoskeleton, basal plasma membrane, brush border, cell cortex, cell projection, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, filamentous actin, lateral plasma membrane, membrane, membrane raft, microvillus, myosin complex, nuclear body, nucleolus, nucleoplasm, nucleus, phagocytic vesicle, plasma membrane, plasma membrane bounded cell projection, ruffle membrane, stereocilium, stereocilium bundle, stereocilium membrane
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Fcgamma receptor (FCGR) dependent phagocytosis, Gene expression (Transcription), Immune System, Innate Immune System, Positive epigenetic regulation of rRNA expression, Regulation of actin dynamics for phagocytic cup formation
UniProt: Q9WTI7
Entrez ID: 17913
|
Does Knockout of Gnat1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Gnat1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gnat1 (G protein subunit alpha transducin 1)
Type: protein-coding
Summary: Enables G-protein beta/gamma-subunit complex binding activity and GTPase activity. Acts upstream of or within several processes, including cellular response to electrical stimulus; detection of light stimulus; and eye photoreceptor cell differentiation. Located in photoreceptor connecting cilium; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in brain; eye; photoreceptor layer outer segment; retina; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1G; congenital stationary night blindness autosomal dominant 3; and night blindness. Orthologous to human GNAT1 (G protein subunit alpha transducin 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled opsin signaling pathway, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, background adaptation, cell population proliferation, cellular response to electrical stimulus, detection of chemical stimulus involved in sensory perception of bitter taste, detection of light stimulus, detection of light stimulus involved in visual perception, dopamine secretion, eye photoreceptor cell development, neural tissue regeneration, phototransduction, phototransduction, visible light, response to light intensity, response to light stimulus, retina development in camera-type eye, retinal cone cell differentiation, retinal rod cell differentiation, sensory perception of umami taste, signal transduction, visual behavior, visual perception; MF: G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, guanyl nucleotide binding, metal ion binding, nucleotide binding, protein binding; CC: apical plasma membrane, cell projection, cytoplasm, heterotrimeric G-protein complex, membrane, neuronal cell body, photoreceptor connecting cilium, photoreceptor inner segment, photoreceptor outer segment
Pathways: Activation of the phototransduction cascade, G alpha (i) signalling events, GPCR downstream signalling, Inactivation, recovery and regulation of the phototransduction cascade, Phototransduction - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by GPCR, The phototransduction cascade, Visual phototransduction, cyclic AMP biosynthesis
UniProt: P20612
Entrez ID: 14685
|
Does Knockout of Apcdd1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Apcdd1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Apcdd1 (adenomatosis polyposis coli down-regulated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, astrocyte cell migration, hair follicle development, negative regulation of Wnt signaling pathway, regulation of odontogenesis of dentin-containing tooth; MF: Wnt-protein binding, identical protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q3U128
Entrez ID: 494504
|
Does Knockout of Htr1b in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,308
|
Knockout
|
Htr1b
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Htr1b (5-hydroxytryptamine (serotonin) receptor 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting serotonin receptor signaling pathway, bone remodeling, cellular response to alkaloid, cellular response to xenobiotic stimulus, chemical synaptic transmission, drinking behavior, feeding behavior, negative regulation of gamma-aminobutyric acid secretion, negative regulation of serotonin secretion, negative regulation of synaptic transmission, GABAergic, negative regulation of synaptic transmission, glutamatergic, phospholipase C-activating serotonin receptor signaling pathway, positive regulation of vascular associated smooth muscle cell proliferation, presynaptic modulation of chemical synaptic transmission, regulation of behavior, regulation of dopamine secretion, regulation of synaptic vesicle exocytosis, response to cocaine, response to ethanol, signal transduction, vasoconstriction; MF: G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, Gi/o-coupled serotonin receptor activity, heterocyclic compound binding, neurotransmitter receptor activity, serotonin binding, serotonin receptor activity, voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; CC: G protein-coupled serotonin receptor complex, calyx of Held, cytoplasm, dendrite, endoplasmic reticulum, membrane, plasma membrane, presynaptic membrane, serotonergic synapse
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Serotonin receptors, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: P28334
Entrez ID: 15551
|
Does Knockout of Mocs3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Mocs3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mocs3 (molybdenum cofactor synthesis 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Mo-molybdopterin cofactor biosynthetic process, molybdopterin cofactor biosynthetic process, protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: ATP binding, URM1 activating enzyme activity, adenylyltransferase activity, catalytic activity, metal ion binding, molybdopterin-synthase adenylyltransferase activity, molybdopterin-synthase sulfurtransferase activity, nucleotide binding, nucleotidyltransferase activity, sulfurtransferase activity, thiosulfate-cyanide sulfurtransferase activity, transferase activity, ubiquitin-like modifier activating enzyme activity; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Molybdenum cofactor biosynthesis, Sulfur relay system - Mus musculus (mouse)
UniProt: A2BDX3
Entrez ID: 69372
|
Does Knockout of Car15 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Car15
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Car15 (carbonic anhydrase 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbonate dehydratase activity, lyase activity, metal ion binding, zinc ion binding; CC: extracellular region, membrane, plasma membrane
Pathways: Nitrogen metabolism - Mus musculus (mouse)
UniProt: Q99N23
Entrez ID: 80733
|
Does Knockout of Dysf in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Dysf
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Dysf (dysferlin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-tubule organization, angiogenesis, cellular response to osmotic stress, fat cell differentiation, glycerol metabolic process, lipid storage, macrophage activation involved in immune response, membrane fusion, monocyte activation involved in immune response, muscle cell development, negative regulation of gene expression, negative regulation of phagocytosis, negative regulation of protein catabolic process, negative regulation of protein polyubiquitination, plasma membrane repair, positive regulation of cell adhesion, positive regulation of endothelial cell proliferation, positive regulation of neutrophil chemotaxis, regulation of calcium ion import, skeletal muscle tissue regeneration, vesicle fusion; MF: alpha-tubulin binding, calcium ion binding, calcium-dependent phospholipid binding, lipid binding, metal ion binding, microtubule binding, phospholipid binding, protein binding; CC: Golgi apparatus, T-tubule, centriolar satellite, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, early endosome, endocytic vesicle, endomembrane system, endosome, lamellipodium, late endosome, late endosome membrane, membrane, membrane microdomain, microtubule, microtubule cytoskeleton, nucleus, plasma membrane, sarcolemma
Pathways:
UniProt: Q9ESD7
Entrez ID: 26903
|
Does Knockout of Ctdsp2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Ctdsp2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ctdsp2 (CTD small phosphatase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of G1/S transition of mitotic cell cycle, regulation of transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat phosphatase activity, hydrolase activity, metal ion binding, phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cellular_component, nucleus
Pathways:
UniProt: Q8BX07
Entrez ID: 52468
|
Does Knockout of Tkfc in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Tkfc
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tkfc (triokinase, FMN cyclase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, carbohydrate phosphorylation, fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate, glycerol catabolic process, glycerol metabolic process, glycolytic process through fructose-1-phosphate, negative regulation of MDA-5 signaling pathway, regulation of innate immune response; MF: ATP binding, FAD-AMP lyase (cyclizing) activity, catalytic activity, glycerone kinase activity, kinase activity, lyase activity, metal ion binding, nucleotide binding, protein binding, transferase activity, triokinase activity; CC: cytosol
Pathways: Fructose and mannose metabolism - Mus musculus (mouse), Fructose catabolism, Fructose metabolism, Glycerolipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, RIG-I-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q8VC30
Entrez ID: 225913
|
Does Knockout of Cdc7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Cdc7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cdc7 (cell division cycle 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell cycle phase transition, cell division, double-strand break repair via break-induced replication, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of nuclear cell cycle DNA replication, signal transduction; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, intercellular bridge, mitotic spindle, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition
UniProt: Q9Z0H0
Entrez ID: 12545
|
Does Knockout of Chuk in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Chuk
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Chuk (conserved helix-loop-helix ubiquitous kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical NF-kappaB signal transduction, cellular response to tumor necrosis factor, cellular response to virus, defense response to virus, integrin-mediated signaling pathway, lactation, mammary gland alveolus development, mammary gland epithelial cell proliferation, morphogenesis of an epithelial sheet, negative regulation of autophagy, negative regulation of canonical NF-kappaB signal transduction, non-canonical NF-kappaB signal transduction, odontogenesis of dentin-containing tooth, osteoclast differentiation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of interferon-alpha production, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, response to cholecystokinin, response to muscle stretch, skin development, striated muscle cell differentiation, toll-like receptor 4 signaling pathway, tumor necrosis factor-mediated signaling pathway; MF: ATP binding, IkappaB kinase activity, kinase activity, nucleotide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, scaffold protein binding, transferase activity, transferrin receptor binding; CC: CD40 receptor complex, IkappaB kinase complex, cytoplasm, cytoplasmic side of plasma membrane, cytosol, nucleoplasm, nucleus
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytosolic DNA-sensing pathway - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: E9Q605, Q3UDK0, Q3TPN9, Q8CBT3, E9QNL4
Entrez ID: 12675
|
Does Knockout of Pou5f1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Pou5f1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Pou5f1 (POU domain, class 5, transcription factor 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein plays a key role in embryonic development and stem cell pluripotency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: blastocyst development, blastocyst growth, cell fate commitment, cellular response to leukemia inhibitory factor, chromatin organization, ectodermal cell fate commitment, endodermal cell fate commitment, endodermal cell fate specification, gene expression, germ-line stem cell population maintenance, intracellular receptor signaling pathway, mesodermal cell fate commitment, negative regulation of DNA-templated transcription, negative regulation of calcium ion-dependent exocytosis, negative regulation of cell differentiation, negative regulation of gene expression, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA-templated transcription, regulation of asymmetric cell division, regulation of transcription by RNA polymerase II, response to benzoic acid, response to cytokine, response to retinoic acid, somatic stem cell population maintenance, stem cell differentiation, stem cell population maintenance, telomere maintenance, transcription by RNA polymerase II, trophectodermal cell differentiation, trophectodermal cell fate commitment; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, HMG box domain binding, POU domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, cytokine binding, histone H3K56ac reader activity, miRNA binding, nuclear receptor activity, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, ubiquitin protein ligase binding; CC: chromatin, cytoplasm, cytosol, female germ cell nucleus, germ cell nucleus, male germ cell nucleus, mitochondrion, nucleolus, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: P20263
Entrez ID: 18999
|
Does Knockout of Rbm11 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Rbm11
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rbm11 (RNA binding motif protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cell differentiation, cellular response to oxidative stress, mRNA processing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, nucleic acid binding, poly(U) RNA binding, protein homodimerization activity, single-stranded RNA binding; CC: nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q80YT9
Entrez ID: 224344
|
Does Knockout of Coro1c in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Coro1c
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Coro1c (coronin, actin binding protein 1C)
Type: protein-coding
Summary: Enables small GTPase binding activity. Involved in several processes, including activation of GTPase activity; regulation of fibroblast migration; and regulation of ruffle assembly. Acts upstream of or within corpus callosum development and ventricular system development. Located in cytoskeleton. Part of flotillin complex. Is expressed in several structures, including brain; dorsal root ganglion; genitourinary system; liver; and spleen. Orthologous to human CORO1C (coronin 1C). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: actin cytoskeleton organization, actin filament organization, activation of GTPase activity, corpus callosum development, endosomal transport, endosome fission, endosome membrane tubulation, establishment of protein localization, macrophage chemotaxis, membrane fission, negative regulation of epithelial cell migration, negative regulation of focal adhesion assembly, negative regulation of substrate adhesion-dependent cell spreading, neural crest cell migration, phagocytosis, positive regulation of lamellipodium morphogenesis, positive regulation of osteoclast differentiation, regulation of epithelial cell migration, regulation of fibroblast migration, regulation of focal adhesion assembly, regulation of ruffle assembly, regulation of substrate adhesion-dependent cell spreading, ventricular system development; MF: actin binding, actin filament binding, protein binding, small GTPase binding; CC: actin cytoskeleton, cell cortex, cell projection, cytoplasm, cytoskeleton, endosome, endosome membrane, flotillin complex, lamellipodium, lateral plasma membrane, membrane, plasma membrane, ruffle membrane, vesicle
Pathways:
UniProt: Q9WUM4
Entrez ID: 23790
|
Does Knockout of Rell2 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Rell2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Rell2 (RELT-like 2)
Type: protein-coding
Summary: Enables collagen binding activity. Acts upstream of or within positive regulation of cell-substrate adhesion. Located in basement membrane. Is expressed in lip; lower jaw molar dental lamina; lower jaw molar enamel organ; and oral epithelium. Orthologous to human RELL2 (RELT like 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: positive regulation of cell-substrate adhesion, positive regulation of p38MAPK cascade; CC: basement membrane, extracellular matrix, membrane, plasma membrane
Pathways:
UniProt: Q8BRJ3
Entrez ID: 225392
|
Does Knockout of Ppbp in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Ppbp
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ppbp (pro-platelet basic protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cellular response to lipopolysaccharide, chemotaxis, defense response, immune response, inflammatory response, killing of cells of another organism, leukocyte migration involved in inflammatory response, neutrophil chemotaxis, positive regulation of granulocyte chemotaxis, signal transduction; MF: CXCR chemokine receptor binding, chemokine activity, cytokine activity; CC: extracellular region, extracellular space, platelet alpha granule
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation, Peptide ligand-binding receptors, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q9EQI5
Entrez ID: 57349
|
Does Knockout of R3hdml in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
R3hdml
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: R3hdml (R3H domain containing-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, peptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: A2A5I3
Entrez ID: 100043899
|
Does Knockout of Rtca in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Rtca
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rtca (RNA 3'-terminal phosphate cyclase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, negative regulation of optical nerve axon regeneration; MF: ATP binding, RNA-3'-phosphate cyclase activity, catalytic activity, ligase activity, nucleotide binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q9D7H3
Entrez ID: 66368
|
Does Knockout of Flot1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Flot1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Flot1 (flotillin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adherens junction organization, axon guidance, axonogenesis, caveola assembly, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, endocytosis, extracellular matrix disassembly, intracellular signal transduction, plasma membrane raft assembly, plasma membrane raft organization, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell junction assembly, positive regulation of cell-cell adhesion mediated by cadherin, positive regulation of endocytosis, positive regulation of synaptic transmission, dopaminergic, protein localization to plasma membrane, regulation of Rho protein signal transduction, regulation of neurotransmitter uptake, regulation of receptor internalization; MF: ionotropic glutamate receptor binding, protease binding, protein binding; CC: COP9 signalosome, GABA-ergic synapse, adherens junction, basolateral plasma membrane, caveola, cell-cell contact zone, cell-cell junction, centriolar satellite, cortical actin cytoskeleton, cytoplasmic vesicle, dopaminergic synapse, early endosome, endosome, external side of plasma membrane, flotillin complex, glutamatergic synapse, lamellipodium, melanosome, membrane, membrane raft, microtubule organizing center, plasma membrane, plasma membrane raft, presynapse, presynaptic active zone, sarcolemma, synapse, uropod
Pathways: Insulin signaling pathway - Mus musculus (mouse)
UniProt: O08917
Entrez ID: 14251
|
Does Knockout of Hcar2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Hcar2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hcar2 (hydroxycarboxylic acid receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, apoptotic process, negative regulation of lipid catabolic process, positive regulation of adiponectin secretion, positive regulation of neutrophil apoptotic process, purinergic nucleotide receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, GTP binding, nicotinic acid receptor activity, purinergic nucleotide receptor activity; CC: cell junction, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Hydroxycarboxylic acid-binding receptors, Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q9EP66
Entrez ID: 80885
|
Does Knockout of Gabra6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Gabra6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gabra6 (gamma-aminobutyric acid type A receptor subunit alpha 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, chloride transport, gamma-aminobutyric acid signaling pathway, inhibitory synapse assembly, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of postsynaptic membrane potential, synaptic transmission, GABAergic; MF: GABA-A receptor activity, GABA-gated chloride ion channel activity, benzodiazepine receptor activity, chloride channel activity, diazepam binding, extracellular ligand-gated monoatomic ion channel activity, heterocyclic compound binding, inhibitory extracellular ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, protein-containing complex binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: GABA-A receptor complex, GABA-ergic synapse, cerebellar Golgi cell to granule cell synapse, chloride channel complex, dendrite, dendrite membrane, hippocampal mossy fiber to CA3 synapse, membrane, neuronal cell body membrane, plasma membrane, postsynapse, postsynaptic membrane, postsynaptic specialization membrane, presynaptic membrane, receptor complex, synapse
Pathways: GABA receptor activation, GABAergic synapse - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Taste transduction - Mus musculus (mouse), Transmission across Chemical Synapses
UniProt: P16305
Entrez ID: 14399
|
Does Knockout of Syce2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Syce2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Syce2 (synaptonemal complex central element protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, meiotic cell cycle, synaptonemal complex assembly; CC: central element, chromosome, nucleoplasm, nucleus, synaptonemal complex
Pathways:
UniProt: Q505B8
Entrez ID: 71846
|
Does Knockout of Gm17175 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Gm17175
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Gm17175 (predicted gene 17175)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102641463
|
Does Knockout of Gpr88 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Gpr88
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gpr88 (G-protein coupled receptor 88)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, adrenergic receptor signaling pathway, cellular response to light stimulus, detection of visible light, locomotory behavior, motor learning, neuromuscular process controlling balance, neuronal action potential, phototransduction, signal transduction; MF: G protein-coupled photoreceptor activity, G protein-coupled receptor activity, beta2-adrenergic receptor activity, cytoskeletal motor activity, transmembrane signaling receptor activity; CC: cell projection, ciliary membrane, cilium, cytoplasm, membrane, nucleus, plasma membrane
Pathways:
UniProt: Q9EPB7
Entrez ID: 64378
|
Does Knockout of Epha3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Epha3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Epha3 (Eph receptor A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, cellular response to follicle-stimulating hormone stimulus, cellular response to retinoic acid, endocardial cushion development, ephrin receptor signaling pathway, fasciculation of motor neuron axon, fasciculation of sensory neuron axon, motor neuron axon guidance, negative regulation of endocytosis, negative regulation of neuron projection development, positive regulation of neuron projection development, positive regulation of protein localization to plasma membrane, regulation of GTPase activity, regulation of actin cytoskeleton organization, regulation of cell migration, regulation of developmental process, regulation of epithelial to mesenchymal transition, regulation of focal adhesion assembly, regulation of microtubule cytoskeleton organization, synapse organization, synaptic membrane adhesion; MF: ATP binding, GPI-linked ephrin receptor activity, ephrin receptor activity, growth factor binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity; CC: GABA-ergic synapse, actin cytoskeleton, cytosol, dendrite, early endosome, extracellular region, membrane, nuclear membrane, nucleoplasm, plasma membrane, presynapse
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q8BRB1, B7ZNN5, Q8C9K6, A0A338P6A7, A0A338P7J9
Entrez ID: 13837
|
Does Knockout of Mplkip in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Mplkip
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mplkip (M-phase specific PLK1 intereacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, centrosome, cytoplasm, cytoskeleton, midbody, nucleoplasm, nucleus
Pathways:
UniProt: Q9D011
Entrez ID: 66308
|
Does Knockout of Ercc8 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,559
|
Knockout
|
Ercc8
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ercc8 (excision repaiross-complementing rodent repair deficiency, complementation group 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via classical nonhomologous end joining, positive regulation of DNA repair, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of transcription-coupled nucleotide-excision repair, response to UV, response to X-ray, response to auditory stimulus, response to oxidative stress, single strand break repair, transcription-coupled nucleotide-excision repair; MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, chromosome, nuclear matrix, nucleotide-excision repair complex, nucleus, perikaryon, protein-containing complex, site of DNA damage
Pathways: DNA Repair, Dual incision in TC-NER, Formation of TC-NER Pre-Incision Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8CFD5
Entrez ID: 71991
|
Does Knockout of Hmbox1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Hmbox1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Hmbox1 (homeobox containing 1)
Type: protein-coding
Summary: Enables telomeric DNA binding activity. Involved in telomere maintenance via telomerase. Located in chromosome, telomeric region and nucleus. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; limb mesenchyme; and urinary system. Orthologous to human HMBOX1 (homeobox containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, telomere maintenance via telomerase, telomere-telomerase complex assembly; MF: DNA binding, double-stranded telomeric DNA binding, identical protein binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, telomeric DNA binding; CC: Cajal body, PML body, centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q8BJA3
Entrez ID: 219150
|
Does Knockout of Cobll1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Cobll1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cobll1 (Cobl-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cell cortex, membrane
Pathways:
UniProt: Q3UMF0
Entrez ID: 319876
|
Does Knockout of Tubal3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Tubal3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tubal3 (tubulin, alpha-like 3)
Type: protein-coding
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be active in cytoplasm and microtubule. Orthologous to human TUBAL3 (tubulin alpha like 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cytoskeleton organization, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, hydrolase activity, metal ion binding, nucleotide binding, structural constituent of cytoskeleton; CC: cytoplasm, cytoskeleton, microtubule
Pathways: Adaptive Immune System, Aggrephagy, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Mus musculus (mouse), Asparagine N-linked glycosylation, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Cilium Assembly, Cytokine Signaling in Immune system, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, G2/M Transition, Gap junction - Mus musculus (mouse), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Mus musculus (mouse), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Mus musculus (mouse), Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q3UX10
Entrez ID: 238463
|
Does Knockout of Tmem132d in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Tmem132d
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tmem132d (transmembrane protein 132D)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q76HP3
Entrez ID: 243274
|
Does Knockout of Tppp2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tppp2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tppp2 (tubulin polymerization-promoting protein family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, microtubule bundle formation, microtubule polymerization, positive regulation of protein polymerization, regulation of flagellated sperm motility, spermatogenesis; MF: tubulin binding; CC: cell projection, cilium, cytoplasm, cytosol, microtubule, motile cilium, sperm flagellum
Pathways:
UniProt: Q0P5Y3
Entrez ID: 219038
|
Does Knockout of Vmn2r15 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Vmn2r15
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Vmn2r15 (vomeronasal 2, receptor 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2WD13, L7N2A0, A0A3B2WCV8, A0A3B2WCC6, A0A3B2WCA7
Entrez ID: 211223
|
Does Knockout of Tbc1d21 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Tbc1d21
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tbc1d21 (TBC1 domain family, member 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, flagellated sperm motility, plasma membrane to endosome transport, sperm axoneme assembly, sperm mitochondrial sheath assembly, spermatogenesis; MF: GTPase activator activity, actin binding, protein binding, small GTPase binding; CC: acrosomal vesicle, cytoplasm, cytoplasmic vesicle, cytoskeleton, sperm midpiece
Pathways:
UniProt: Q9D9D3
Entrez ID: 74286
|
Does Knockout of Spats2l in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Spats2l
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Spats2l (spermatogenesis associated, serine-rich 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q91WJ7
Entrez ID: 67198
|
Does Knockout of Prl3b1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Prl3b1
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Prl3b1 (prolactin family 3, subfamily b, member 1)
Type: protein-coding
Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Is expressed in several structures, including brain; extraembryonic component; and genitourinary system. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels; MF: hormone activity, prolactin receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: P09586
Entrez ID: 18776
|
Does Knockout of Serpinb9c in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Serpinb9c
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Serpinb9c (serine (or cysteine) peptidase inhibitor, clade B, member 9c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, extracellular space
Pathways: Amoebiasis - Mus musculus (mouse)
UniProt: I7HJI5, Q9D6A7, Q80WW4, J3JSA2
Entrez ID: 20707
|
Does Knockout of Slc6a11 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Slc6a11
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc6a11 (solute carrier family 6 (neurotransmitter transporter, GABA), member 11)
Type: protein-coding
Summary: Enables gamma-aminobutyric acid:sodium:chloride symporter activity and taurine:sodium symporter activity. Involved in neurotransmitter uptake. Is active in synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and liver and biliary system. Orthologous to human SLC6A11 (solute carrier family 6 member 11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: amino acid transmembrane transport, amino acid transport, gamma-aminobutyric acid transport, monocarboxylic acid transport, neurotransmitter transport, neurotransmitter uptake, response to xenobiotic stimulus, sodium ion transmembrane transport, taurine transmembrane transport; MF: amino acid binding, amino acid:sodium symporter activity, gamma-aminobutyric acid:sodium:chloride symporter activity, monocarboxylic acid transmembrane transporter activity, symporter activity, taurine:sodium symporter activity; CC: GABA-ergic synapse, cell projection, membrane, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse
Pathways: Creatine metabolism, GABA synthesis, release, reuptake and degradation, GABAergic synapse - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Neuronal System, Neurotransmitter release cycle, Reuptake of GABA, SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules
UniProt: P31650
Entrez ID: 243616
|
Does Knockout of Ube2t in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Ube2t
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ube2t (ubiquitin-conjugating enzyme E2T)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, protein K6-linked ubiquitination, protein K63-linked ubiquitination, protein autoubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination; MF: ATP binding, chromatin binding, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity; CC: nucleolus, nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes
UniProt: Q9CQ37
Entrez ID: 67196
|
Does Knockout of Ppp1r3c in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Ppp1r3c
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ppp1r3c (protein phosphatase 1, regulatory subunit 3C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycogen biosynthetic process, glycogen metabolic process, protein targeting, regulation of glycogen biosynthetic process, regulation of glycogen catabolic process; MF: [phosphorylase] phosphatase activity, enzyme binding, glycogen binding, molecular adaptor activity, phosphoprotein phosphatase activity, protein phosphatase 1 binding, protein phosphatase binding; CC: cytosol, glycogen granule, protein phosphatase type 1 complex
Pathways: Glycogen metabolism, Glycogen synthesis, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q7TMB3
Entrez ID: 53412
|
Does Knockout of Cln3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Cln3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cln3 (CLN3 lysosomal/endosomal transmembrane protein, battenin)
Type: protein-coding
Summary: This gene encodes a transmembrane protein called battenin that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis genes, cause a number of neurodegenerative diseases collectively known as neuronal ceroid lipofuscinoses, the most common of which is juvenile neuronal ceroid-lipofuscinosis (Batten disease). Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: Golgi to lysosome transport, L-arginine transmembrane transport, actin cytoskeleton organization, action potential, amino acid transport, amyloid precursor protein catabolic process, associative learning, autophagosome maturation, autophagosome-lysosome fusion, blood vessel endothelial cell migration, endocytosis, establishment of localization in cell, glycerophospholipid biosynthetic process, glycolipid transport, intracellular monoatomic cation homeostasis, intracellular water homeostasis, ionotropic glutamate receptor signaling pathway, learning or memory, lysosomal lumen acidification, lysosomal lumen pH elevation, lysosomal protein catabolic process, lysosome organization, macroautophagy, membrane organization, negative regulation of apoptotic process, negative regulation of neuron apoptotic process, negative regulation of proteolysis, neuromuscular process controlling balance, phagosome-lysosome docking, phagosome-lysosome fusion, plasma membrane raft organization, positive regulation of Golgi to plasma membrane protein transport, positive regulation of caveolin-mediated endocytosis, positive regulation of pinocytosis, protein localization to membrane, protein localization to plasma membrane, protein processing, receptor-mediated endocytosis, regulation of arginine biosynthetic process, regulation of autophagosome maturation, regulation of autophagosome size, regulation of autophagy, regulation of biological quality, regulation of cellular response to osmotic stress, regulation of cytoskeleton organization, regulation of cytosolic calcium ion concentration, regulation of fibroblast migration, regulation of filopodium assembly, regulation of gene expression, regulation of modification of synaptic structure, regulation of phagosome maturation, regulation of protein localization to plasma membrane, regulation of protein processing, regulation of proteolysis, regulation of short-term neuronal synaptic plasticity, regulation of synaptic transmission, GABAergic, regulation of synaptic transmission, glutamatergic, renal potassium excretion, vesicle transport along microtubule; MF: calcium-dependent protein binding, glycolipid binding, protein binding, sulfatide binding; CC: Golgi apparatus, Golgi membrane, Golgi stack, autolysosome, autophagosome, caveola, cytoplasm, cytoplasmic vesicle, cytosol, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, membrane raft, neuron projection, nucleus, plasma membrane, recycling endosome, synapse, synaptic vesicle, trans-Golgi network
Pathways: Glycosphingolipid transport, Lysosome - Mus musculus (mouse), Transport of small molecules
UniProt: Q61124
Entrez ID: 12752
|
Does Knockout of Tmem35b in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Tmem35b
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tmem35b (transmembrane protein 35B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q3U0Y2
Entrez ID: 100039968
|
Does Knockout of Bsn in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Bsn
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bsn (bassoon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axo-dendritic transport, maintenance of presynaptic active zone structure, modulation of chemical synaptic transmission, presynaptic active zone assembly, presynaptic active zone organization, protein localization to synapse, regulation of synaptic vesicle cycle, retrograde axonal transport, synapse organization, synaptic vesicle clustering; MF: dynein light chain binding, enzyme inhibitor activity, metal ion binding, protein binding, structural constituent of presynaptic active zone, transcription corepressor binding, zinc ion binding; CC: GABA-ergic synapse, Golgi-associated vesicle, Schaffer collateral - CA1 synapse, axon, axon cytoplasm, cell cortex, cell projection, cell surface, cochlear hair cell ribbon synapse, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytoskeleton of presynaptic active zone, cytosol, dendrite, excitatory synapse, extrinsic component of membrane, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, inhibitory synapse, neuron projection terminus, neuronal cell body, organelle, piccolo-bassoon transport vesicle, postsynaptic density, presynapse, presynaptic active zone, presynaptic active zone cytoplasmic component, ribbon synapse, synapse, synaptic membrane, synaptic vesicle, trans-Golgi network
Pathways:
UniProt: O88737
Entrez ID: 12217
|
Does Knockout of Slc11a1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Slc11a1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Slc11a1 (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-arginine transmembrane transport, MHC class II biosynthetic process, T cell proliferation involved in immune response, antigen processing and presentation of peptide antigen, cadmium ion transmembrane transport, cellular detoxification of cadmium ion, defense response to Gram-negative bacterium, defense response to bacterium, defense response to protozoan, establishment of localization in cell, inflammatory response, intracellular iron ion homeostasis, intracellular manganese ion homeostasis, iron ion transmembrane transport, iron ion transport, mRNA stabilization, macrophage activation, manganese ion transmembrane transport, manganese ion transport, metal ion transport, monoatomic ion transport, multicellular organismal-level iron ion homeostasis, negative regulation of cytokine production, nitrite transport, phagocytosis, positive regulation of T-helper 1 type immune response, positive regulation of cytokine production, positive regulation of dendritic cell antigen processing and presentation, positive regulation of gene expression, positive regulation of phagocytosis, positive regulation of transcription by RNA polymerase II, positive regulation of type II interferon production, proton transmembrane transport, respiratory burst, response to bacterium, response to lipopolysaccharide, response to type II interferon, vacuolar acidification, wound healing; MF: iron ion transmembrane transporter activity, manganese ion transmembrane transporter activity, metal cation:proton antiporter activity, metal ion transmembrane transporter activity, protein homodimerization activity, transition metal ion transmembrane transporter activity; CC: endosome, endosome membrane, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, phagocytic vesicle membrane, plasma membrane, tertiary granule membrane
Pathways: Antimicrobial peptides, Immune System, Innate Immune System, Ion influx/efflux at host-pathogen interface, Lysosome - Mus musculus (mouse), Metal ion SLC transporters, Neutrophil degranulation, ROS and RNS production in phagocytes, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: P41251
Entrez ID: 18173
|
Does Knockout of Mpzl2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Mpzl2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mpzl2 (myelin protein zero-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation in thymus, cell adhesion, cell-cell adhesion; CC: membrane, plasma membrane
Pathways:
UniProt: A0A1L1STN6, F6RG10, A0A1L1SST8
Entrez ID: 14012
|
Does Knockout of Rad54l2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Rad54l2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rad54l2 (RAD54 like 2 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of transcription by RNA polymerase II; MF: ATP binding, ATP hydrolysis activity, ATP-dependent chromatin remodeler activity, DNA binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, protein kinase binding, transcription coregulator activity; CC: nuclear body, nuclear speck, nucleus
Pathways:
UniProt: Q99NG0
Entrez ID: 81000
|
Does Knockout of Ift46 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Ift46
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ift46 (intraflagellar transport 46)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axoneme assembly, cilium assembly, cilium organization, cilium-dependent cell motility, intraciliary anterograde transport, intraciliary transport, protein transport, regulation of cilium assembly, regulation of protein stability, smoothened signaling pathway; CC: cell projection, centrosome, ciliary base, ciliary membrane, cilium, cytoplasm, cytoskeleton, intraciliary transport particle B, microtubule organizing center, motile cilium, plasma membrane bounded cell projection
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance
UniProt: Q9DB07
Entrez ID: 76568
|
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