prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Pcdhga9 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Pcdhga9
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcdhga9 (protocadherin gamma subfamily A, 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, metal ion binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q91XX9
Entrez ID: 93717
|
Does Knockout of Cavin3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Cavin3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cavin3 (caveolae associated 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian regulation of gene expression, cortical actin cytoskeleton organization, negative regulation of fermentation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of ERK1 and ERK2 cascade, rhythmic process; MF: protein binding, protein kinase C binding; CC: caveola, cytoplasm, cytosol, membrane, protein-containing complex
Pathways:
UniProt: Q91VJ2
Entrez ID: 109042
|
Does Knockout of Rnf26 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Rnf26
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rnf26 (ring finger protein 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome organization, negative regulation of defense response to virus, protein K11-linked ubiquitination, protein localization to perinuclear region of cytoplasm, protein ubiquitination, regulation of type I interferon production, ubiquitin-dependent protein catabolic process; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8BUH7
Entrez ID: 213211
|
Does Knockout of Gmeb1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Gmeb1
|
cell proliferation
|
Regulatory T cell
|
Gene: Gmeb1 (glucocorticoid modulatory element binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, Hsp27 protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q9JL60
Entrez ID: 56809
|
Does Knockout of Il4i1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Il4i1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Il4i1 (interleukin 4 induced 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-phenylalanine catabolic process, L-tryptophan catabolic process, L-tryptophan catabolic process to indole-3-acetate, L-tyrosine catabolic process, adaptive immune response, amino acid catabolic process, aromatic amino acid metabolic process, immune system process, negative regulation of T cell activation, negative regulation of T cell mediated immune response to tumor cell, negative regulation of T cell proliferation, positive regulation of regulatory T cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of B cell differentiation, regulation of adaptive immune response; MF: L-amino-acid oxidase activity, L-phenylalaine oxidase activity, oxidoreductase activity; CC: acrosomal vesicle, cytoplasm, cytoplasmic vesicle, extracellular region, immunological synapse, lysosome, sperm midpiece
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Cysteine and methionine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Phenylalanine and tyrosine metabolism, Phenylalanine metabolism, Phenylalanine metabolism - Mus musculus (mouse), Phenylalanine, tyrosine and tryptophan biosynthesis - Mus musculus (mouse), Tryptophan metabolism - Mus musculus (mouse), Tyrosine metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse)
UniProt: O09046
Entrez ID: 14204
|
Does Knockout of Sik2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Sik2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Sik2 (salt inducible kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, insulin receptor signaling pathway, intracellular signal transduction, lipid biosynthetic process, negative regulation of carbohydrate metabolic process, negative regulation of glycolytic process, negative regulation of lipid biosynthetic process, negative regulation of small molecule metabolic process, negative regulation of transcription from RNA polymerase II promoter by glucose, positive regulation of glycolytic process, positive regulation of transcription from RNA polymerase II promoter by glucose, protein autophosphorylation, protein phosphorylation, regulation of insulin receptor signaling pathway; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, endoplasmic reticulum membrane, nucleus
Pathways: Glucagon signaling pathway - Mus musculus (mouse)
UniProt: Q8CFH6
Entrez ID: 235344
|
Does Knockout of Senp5 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Senp5
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Senp5 (SUMO/sentrin specific peptidase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, protein desumoylation, proteolysis; MF: SUMO-specific endopeptidase activity, cysteine-type peptidase activity, deSUMOylase activity, hydrolase activity, peptidase activity; CC: nucleolus, nucleus, postsynaptic cytosol, presynaptic cytosol
Pathways: Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, SUMO is proteolytically processed, SUMOylation
UniProt: Q6NXL6
Entrez ID: 320213
|
Does Knockout of Prm3 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Prm3
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Prm3 (protamine 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chromosome condensation, flagellated sperm motility, spermatogenesis; CC: chromosome, cytoplasm, nucleosome, nucleus
Pathways:
UniProt: Q62100
Entrez ID: 19120
|
Does Knockout of Cenpc1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Cenpc1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cenpc1 (centromere protein C1)
Type: protein-coding
Summary: This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore assembly, mitotic cell cycle, spindle attachment to meiosis I kinetochore; MF: DNA binding, centromeric DNA binding, identical protein binding, protein binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, centromeric region, inner kinetochore, kinetochore, midbody, nuclear body, nucleoplasm, nucleus, pericentric heterochromatin
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P49452
Entrez ID: 12617
|
Does Knockout of Mtss1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Mtss1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mtss1 (MTSS I-BAR domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, actin filament polymerization, adherens junction maintenance, bone mineralization, cellular response to fluid shear stress, epithelial cell proliferation involved in renal tubule morphogenesis, glomerulus morphogenesis, in utero embryonic development, magnesium ion homeostasis, metanephric tubule development, muscle organ development, negative regulation of epithelial cell proliferation, nephron tubule epithelial cell differentiation, nervous system development, plasma membrane organization, positive regulation of actin filament bundle assembly, renal tubule morphogenesis; MF: actin binding, actin filament binding, actin monomer binding, identical protein binding, phospholipid binding, protein binding, signaling receptor binding; CC: actin cytoskeleton, adherens junction, cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton
Pathways:
UniProt: Q8R1S4
Entrez ID: 211401
|
Does Knockout of Kdm1a in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,666
|
Knockout
|
Kdm1a
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Kdm1a (lysine (K)-specific demethylase 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair-dependent chromatin remodeling, cell differentiation, cellular response to UV, cellular response to gamma radiation, chromatin organization, epigenetic regulation of gene expression, epithelial to mesenchymal transition, granulocyte differentiation, guanine metabolic process, muscle cell development, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of neurogenesis, negative regulation of transcription by RNA polymerase II, negative regulation of transcription initiation-coupled chromatin remodeling, neuron projection extension, neuron projection morphogenesis, pituitary gland development, positive regulation of cell differentiation, positive regulation of cold-induced thermogenesis, positive regulation of epithelial to mesenchymal transition, positive regulation of erythrocyte differentiation, positive regulation of megakaryocyte differentiation, positive regulation of multicellular organismal process, positive regulation of neural precursor cell proliferation, positive regulation of neuroblast proliferation, positive regulation of protein ubiquitination, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of double-strand break repair via homologous recombination, regulation of neurogenesis, regulation of primitive erythrocyte differentiation, regulation of protein localization, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor binding, FAD-dependent H3K4me/H3K4me3 demethylase activity, MRF binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, enzyme binding, flavin adenine dinucleotide binding, histone H3K4 demethylase activity, histone H3K9 demethylase activity, histone H3K9me2/H3K9me3 demethylase activity, histone demethylase activity, identical protein binding, lncRNA binding, nuclear androgen receptor binding, oxidoreductase activity, p53 binding, promoter-specific chromatin binding, protein binding, protein demethylase activity, telomeric repeat-containing RNA binding, transcription coactivator activity, transcription corepressor activity; CC: DNA repair complex, chromatin, chromosome, chromosome, telomeric region, histone methyltransferase complex, nucleoplasm, nucleus, protein-containing complex
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chromatin modifying enzymes, Chromatin organization, ESR-mediated signaling, Estrogen-dependent gene expression, Factors involved in megakaryocyte development and platelet production, HDACs deacetylate histones, HDMs demethylate histones, Hemostasis, Negative Regulation of CDH1 Gene Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signal Transduction, Signaling by Nuclear Receptors, Thermogenesis - Mus musculus (mouse)
UniProt: Q6ZQ88
Entrez ID: 99982
|
Does Knockout of Pus7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Pus7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pus7 (pseudouridylate synthase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, RNA splicing, mRNA processing, mRNA pseudouridine synthesis, negative regulation of translation, pseudouridine synthesis, regulation of hematopoietic stem cell differentiation, regulation of mesoderm development, tRNA processing, tRNA pseudouridine synthesis; MF: RNA binding, enzyme binding, isomerase activity, pseudouridine synthase activity, tRNA pseudouridine synthase activity, tRNA pseudouridine(13) synthase activity; CC: nucleus
Pathways:
UniProt: Q91VU7
Entrez ID: 78697
|
Does Knockout of Prpf40a in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Prpf40a
|
phagocytosis
|
macrophage
|
Gene: Prpf40a (pre-mRNA processing factor 40A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cell migration, cytoskeleton organization, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, regulation of cell shape, regulation of cytokinesis; MF: RNA binding, proline-rich region binding, protein binding; CC: U1 snRNP, U2-type prespliceosome, nuclear matrix, nuclear speck, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9R1C7
Entrez ID: 56194
|
Does Knockout of Defb37 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Defb37
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Defb37 (defensin beta 37)
Type: protein-coding
Summary: Predicted to enable CCR6 chemokine receptor binding activity and identical protein binding activity. Predicted to be involved in calcium-mediated signaling; defense response to other organism; and positive regulation of flagellated sperm motility involved in capacitation. Predicted to be located in membrane; microvesicle; and sperm midpiece. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, innate immune response in mucosa, response to bacterium; CC: extracellular region, extracellular space
Pathways:
UniProt: Q7TMD2
Entrez ID: 353320
|
Does Knockout of Nol8 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Nol8
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nol8 (nucleolar protein 8)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in chromosome. Predicted to be active in nucleolus. Is expressed in central nervous system and sensory organ. Orthologous to human NOL8 (nucleolar protein 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to leukemia inhibitory factor, protein localization to nucleolus, rRNA processing; MF: RNA binding, nucleic acid binding; CC: chromosome, nucleolus, nucleus
Pathways:
UniProt: Q3UHX0
Entrez ID: 70930
|
Does Knockout of Pitpnc1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Pitpnc1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Pitpnc1 (phosphatidylinositol transfer protein, cytoplasmic 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermembrane lipid transfer, lipid transport, phosphatidylinositol metabolic process, phospholipid transport, signal transduction; MF: lipid binding, phosphatidic acid binding, phosphatidic acid transfer activity, phosphatidylglycerol binding, phosphatidylinositol binding, phosphatidylinositol transfer activity, phospholipid transporter activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8K4R4
Entrez ID: 71795
|
Does Knockout of Onecut2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Onecut2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Onecut2 (one cut domain, family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, cell fate commitment, cilium assembly, endocrine pancreas development, epithelial cell development, liver development, negative regulation of transforming growth factor beta receptor signaling pathway, pancreas development, peripheral nervous system neuron development, positive regulation of mesenchymal stem cell migration, positive regulation of transcription by RNA polymerase II, regulation of cell-matrix adhesion, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: actin cytoskeleton, nucleoplasm, nucleus
Pathways:
UniProt: Q6XBJ3
Entrez ID: 225631
|
Does Knockout of Cacna1c in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Cacna1c
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit)
Type: protein-coding
Summary: Enables enzyme binding activity and voltage-gated calcium channel activity involved in cardiac muscle cell action potential. Involved in positive regulation of adenylate cyclase activity. Acts upstream of or within several processes, including adult walking behavior; regulation of blood circulation; and secretion by cell. Located in several cellular components, including T-tubule; Z disc; and dendritic shaft. Part of caveolar macromolecular signaling complex and voltage-gated calcium channel complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and heart. Used to study Timothy syndrome. Human ortholog(s) of this gene implicated in Brugada syndrome 3; Timothy syndrome; long QT syndrome 8; and neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: adult walking behavior, calcium ion import, calcium ion import across plasma membrane, calcium ion transmembrane import into cytosol, calcium ion transmembrane transport, calcium ion transmembrane transport via high voltage-gated calcium channel, calcium ion transport, calcium ion transport into cytosol, calcium-ion regulated exocytosis, camera-type eye development, cardiac conduction, cardiac muscle cell action potential involved in contraction, cell communication, cell communication involved in cardiac conduction, chemical synaptic transmission, embryonic forelimb morphogenesis, establishment of localization in cell, exocytosis, glucose homeostasis, growth hormone secretion, heart development, immune system development, insulin secretion, intracellular calcium ion homeostasis, membrane depolarization during AV node cell action potential, membrane depolarization during atrial cardiac muscle cell action potential, membrane depolarization during cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of adenylate cyclase activity, positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, positive regulation of cytosolic calcium ion concentration, positive regulation of insulin secretion, positive regulation of membrane depolarization, positive regulation of muscle contraction, regulation of blood pressure, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of heart contraction, regulation of heart rate by cardiac conduction, regulation of membrane potential, regulation of organ growth, regulation of vasoconstriction, regulation of ventricular cardiac muscle cell action potential, signaling, smooth muscle contraction, smooth muscle contraction involved in micturition, system process, transmembrane transport, visual learning; MF: alpha-actinin binding, calcium channel activity, calmodulin binding, enzyme binding, high voltage-gated calcium channel activity, metal ion binding, monoatomic ion channel activity, protein binding, protein domain specific binding, protein phosphatase 2A binding, translation initiation factor binding, transmembrane transporter binding, voltage-gated calcium channel activity, voltage-gated calcium channel activity involved in AV node cell action potential, voltage-gated calcium channel activity involved in cardiac muscle cell action potential; CC: L-type voltage-gated calcium channel complex, T-tubule, Z disc, axon, caveolar macromolecular signaling complex, cell projection, cell surface, cilium, cytoplasm, dendrite, dendritic shaft, glutamatergic synapse, membrane, monoatomic ion channel complex, neuronal cell body, nucleoplasm, perikaryon, plasma membrane, plasma membrane protein complex, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, presynaptic membrane, protein-containing complex, sarcolemma, synapse, transmembrane transporter complex, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), GABAergic synapse - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Long-term potentiation - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism, Muscle contraction, Oxytocin signaling pathway - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phase 0 - rapid depolarisation, Phase 2 - plateau phase, Prion disease - Mus musculus (mouse), Regulation of insulin secretion, Renin secretion - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Taste transduction - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q01815
Entrez ID: 12288
|
Does Knockout of Cic in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Cic
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Cic (capicua transcriptional repressor)
Type: protein-coding
Summary: Enables chromatin binding activity. Involved in several processes, including learning or memory; negative regulation of DNA-templated transcription; and social behavior. Acts upstream of or within lung alveolus development and negative regulation of transcription by RNA polymerase II. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; hemolymphoid system; and urinary system. Used to study disease of mental health. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 45. Orthologous to human CIC (capicua transcriptional repressor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: brain development, learning, lung alveolus development, memory, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, social behavior; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, protein binding; CC: nucleoplasm, nucleus, protein-containing complex
Pathways: Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q924A2
Entrez ID: 71722
|
Does Knockout of Cinp in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Cinp
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cinp (cyclin dependent kinase 2 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, biological_process, cell division, ribosomal large subunit biogenesis, ribosome biogenesis; MF: molecular_function, preribosome binding; CC: cellular_component, nucleus
Pathways:
UniProt: Q9D0V8
Entrez ID: 67236
|
Does Knockout of Ifna11 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Ifna11
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Ifna11 (interferon alpha 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to virus, humoral immune response, natural killer cell activation, natural killer cell activation involved in immune response, negative regulation of cell population proliferation, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Alcoholic liver disease - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Cytosolic DNA-sensing pathway - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of IFNA/IFNB signaling, Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q61716
Entrez ID: 15964
|
Does Knockout of Tal1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Tal1
|
cell proliferation
|
Regulatory T cell
|
Gene: Tal1 (T cell acute lymphocytic leukemia 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, astrocyte fate commitment, basophil differentiation, cell differentiation, cell fate commitment, central nervous system neuron differentiation, definitive hemopoiesis, embryonic hemopoiesis, erythrocyte differentiation, erythrocyte maturation, generation of neurons, hemangioblast cell differentiation, hematopoietic stem cell differentiation, hemopoiesis, locomotory behavior, megakaryocyte development, megakaryocyte differentiation, myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, platelet formation, positive regulation of DNA-templated transcription, positive regulation of cell division, positive regulation of chromatin organization, positive regulation of erythrocyte differentiation, positive regulation of mitotic cell cycle, positive regulation of protein-containing complex assembly, positive regulation of transcription by RNA polymerase II, regulation of cell population proliferation, regulation of mast cell differentiation, regulation of myeloid cell differentiation, regulation of somatic stem cell population maintenance, regulation of transcription by RNA polymerase II, spinal cord association neuron differentiation, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, enzyme binding, histone deacetylase binding, protein binding, protein dimerization activity, transcription cis-regulatory region binding; CC: chromatin, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Transcriptional regulation by RUNX1
UniProt: P22091
Entrez ID: 21349
|
Does Knockout of Vat1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Vat1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Vat1 (vesicle amine transport 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermembrane phospholipid transfer, negative regulation of mitochondrial fusion; MF: NADPH dehydrogenase (quinone) activity, oxidoreductase activity, phospholipid transfer activity, zinc ion binding; CC: cytoplasm, membrane, mitochondrial outer membrane, mitochondrion
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q62465
Entrez ID: 26949
|
Does Knockout of Cd3d in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Cd3d
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Cd3d (CD3 antigen, delta polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, adaptive immune response, cell surface receptor signaling pathway, immune system process, positive thymic T cell selection, protein-containing complex assembly; MF: identical protein binding, protein binding, transmembrane signaling receptor activity; CC: T cell receptor complex, alpha-beta T cell receptor complex, external side of plasma membrane, membrane, plasma membrane
Pathways: Adaptive Immune System, Cargo recognition for clathrin-mediated endocytosis, Chagas disease - Mus musculus (mouse), Clathrin-mediated endocytosis, Co-inhibition by PD-1, Downstream TCR signaling, Epstein-Barr virus infection - Mus musculus (mouse), Generation of second messenger molecules, Hematopoietic cell lineage - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Measles - Mus musculus (mouse), Membrane Trafficking, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Phosphorylation of CD3 and TCR zeta chains, Primary immunodeficiency - Mus musculus (mouse), Regulation of T cell activation by CD28 family, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Translocation of ZAP-70 to Immunological synapse, Vesicle-mediated transport
UniProt: P04235
Entrez ID: 12500
|
Does Knockout of N4bp2l1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
N4bp2l1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: N4bp2l1 (NEDD4 binding protein 2-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3V2Q8
Entrez ID: 100637
|
Does Knockout of Txn1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Txn1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Txn1 (thioredoxin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell redox homeostasis, cellular detoxification of hydrogen peroxide, cellular homeostasis, negative regulation of protein export from nucleus, negative regulation of transcription by RNA polymerase II, positive regulation of DNA binding, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, response to nitric oxide, response to radiation; MF: enzyme binding, protein binding, protein homodimerization activity, protein-disulfide reductase [NAD(P)H] activity, protein-disulfide reductase activity; CC: axon, cytoplasm, cytosol, dendrite, extracellular region, mitochondrion, neuronal cell body, nucleoplasm, nucleus
Pathways: Cellular Senescence, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Immune System, Inflammasomes, Innate Immune System, Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Metabolism of proteins, NOD-like receptor signaling pathway - Mus musculus (mouse), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oxidative Stress Induced Senescence, Parkinson disease - Mus musculus (mouse), Protein repair, RNA Polymerase II Transcription, Salmonella infection - Mus musculus (mouse), TP53 Regulates Metabolic Genes, The NLRP3 inflammasome, Transcriptional Regulation by TP53
UniProt: P10639
Entrez ID: 22166
|
Does Knockout of Rpl37 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Rpl37
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Rpl37 (ribosomal protein L37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, positive regulation of signal transduction by p53 class mediator, translation, translation at postsynapse, translation at presynapse; MF: MDM2/MDM4 family protein binding, RNA binding, growth factor binding, metal ion binding, rRNA binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity, zinc ion binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D823
Entrez ID: 67281
|
Does Knockout of Kmt2a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Kmt2a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Kmt2a (lysine (K)-specific methyltransferase 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 2 cell differentiation, anterior/posterior pattern specification, cellular response to transforming growth factor beta stimulus, chromatin organization, circadian regulation of gene expression, cognition, definitive hemopoiesis, embryonic hemopoiesis, epigenetic regulation of gene expression, exploration behavior, homeostasis of number of cells within a tissue, immune system process, membrane depolarization, methylation, negative regulation of DNA methylation-dependent heterochromatin formation, negative regulation of fibroblast proliferation, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, post-embryonic development, protein-containing complex assembly, regulation of DNA-templated transcription, regulation of gene expression, regulation of short-term neuronal synaptic plasticity, response to light stimulus, response to potassium ion, rhythmic process, spleen development, transcription initiation-coupled chromatin remodeling, visual learning; MF: DNA binding, DNA-binding transcription factor binding, chromatin binding, histone H3K4 methyltransferase activity, histone H3K4 monomethyltransferase activity, histone H3K4 trimethyltransferase activity, identical protein binding, metal ion binding, methyltransferase activity, protein binding, protein homodimerization activity, protein-cysteine methyltransferase activity, transferase activity, unmethylated CpG binding, zinc ion binding; CC: MLL1 complex, cytosol, histone methyltransferase complex, nucleoplasm, nucleus
Pathways: Cushing syndrome - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt:
Entrez ID: 214162
|
Does Knockout of Tmem91 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Tmem91
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tmem91 (transmembrane protein 91)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: intracellular membrane-bounded organelle, membrane
Pathways:
UniProt: Q8C581
Entrez ID: 320208
|
Does Knockout of Ubqln2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Ubqln2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ubqln2 (ubiquilin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, autophagosome assembly, autophagy, negative regulation of G protein-coupled receptor internalization, negative regulation of clathrin-dependent endocytosis, positive regulation of ERAD pathway, regulation of autophagosome assembly, regulation of macroautophagy, ubiquitin-dependent protein catabolic process; MF: identical protein binding, molecular condensate scaffold activity, polyubiquitin modification-dependent protein binding, protein binding; CC: autophagosome, cytoplasm, cytoplasmic vesicle, cytosol, membrane, nucleus, plasma membrane
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q9QZM0
Entrez ID: 54609
|
Does Knockout of Kcnk6 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Kcnk6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kcnk6 (potassium inwardly-rectifying channel, subfamily K, member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of systemic arterial blood pressure, positive regulation of NLRP3 inflammasome complex assembly, potassium ion transmembrane transport, potassium ion transport, regulation of lysosome size, regulation of resting membrane potential, regulation of systemic arterial blood pressure; MF: metal ion binding, outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity; CC: endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: Cardiac conduction, Muscle contraction, Neuronal System, Phase 4 - resting membrane potential, Potassium Channels, Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), Tandem pore domain potassium channels
UniProt: Q3TBV4
Entrez ID: 52150
|
Does Knockout of Ighv1-73 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Ighv1-73
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Ighv1-73 (immunoglobulin heavy variable 1-73)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of 1700102P08Rik in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
1700102P08Rik
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: 1700102P08Rik (RIKEN cDNA 1700102P08 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, spermatogenesis
Pathways:
UniProt: Q9D9C7
Entrez ID: 112418
|
Does Knockout of Med12 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Med12
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Med12 (mediator complex subunit 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell development, Wnt signaling pathway, planar cell polarity pathway, axis elongation involved in somitogenesis, embryonic brain development, embryonic neurocranium morphogenesis, embryonic organ development, endoderm development, heart development, neural tube closure, neural tube development, oligodendrocyte development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, post-anal tail morphogenesis, protein ubiquitination, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance, somitogenesis, spinal cord development; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, beta-catenin binding, chromatin binding, nuclear thyroid hormone receptor binding, protein binding, transcription coactivator activity, transcription coregulator activity, ubiquitin protein ligase activity; CC: CKM complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: A2AGH6
Entrez ID: 59024
|
Does Knockout of Rps6ka4 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Rps6ka4
|
cell cycle progression
|
breast epithelium
|
Gene: Rps6ka4 (ribosomal protein S6 kinase, polypeptide 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, chromatin remodeling, inflammatory response, interleukin-1-mediated signaling pathway, intracellular signal transduction, positive regulation of transcription by RNA polymerase II, post-translational protein modification, protein phosphorylation, regulation of DNA-templated transcription; MF: ATP binding, histone H3S10 kinase activity, histone H3S28 kinase activity, kinase activity, magnesium ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, synapse
Pathways: MAPK signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: Q9Z2B9
Entrez ID: 56613
|
Does Knockout of Zfp462 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Zfp462
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Zfp462 (zinc finger protein 462)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: B1AWL2
Entrez ID: 242466
|
Does Knockout of Snx33 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Snx33
|
cell cycle progression
|
breast epithelium
|
Gene: Snx33 (sorting nexin 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cleavage furrow formation, endocytosis, endosomal transport, endosome organization, intracellular protein transport, macropinocytosis, mitotic cell cycle, mitotic cytokinesis, negative regulation of endocytosis, negative regulation of protein localization to cell surface, plasma membrane tubulation, positive regulation of membrane protein ectodomain proteolysis, positive regulation of protein localization to cell surface, protein import, protein transport; MF: identical protein binding, phosphatidylinositol binding; CC: cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, membrane, plasma membrane
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q4VAA7
Entrez ID: 235406
|
Does Knockout of Glis2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Glis2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Glis2 (GLIS family zinc finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell differentiation involved in kidney development, central nervous system development, hematopoietic stem cell homeostasis, kidney development, negative regulation of DNA-templated transcription, negative regulation of smoothened signaling pathway, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of DNA-templated transcription, positive regulation of protein localization to nucleus, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: cytoplasm, non-motile cilium, nuclear speck, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q8VDL9
Entrez ID: 83396
|
Does Knockout of Cib1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Cib1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cib1 (calcium and integrin binding 1)
Type: protein-coding
Summary: Enables protein-membrane adaptor activity and transmembrane transporter binding activity. Involved in several processes, including negative regulation of megakaryocyte differentiation; regulation of intracellular signal transduction; and regulation of protein phosphorylation. Located in cytoplasm and sarcolemma. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human CIB1 (calcium and integrin binding 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA damage response, angiogenesis, apoptotic process, cell adhesion, cell differentiation, cell division, cellular response to growth factor stimulus, cellular response to nerve growth factor stimulus, cellular response to tumor necrosis factor, cytoplasmic microtubule organization, endomitotic cell cycle, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of megakaryocyte differentiation, negative regulation of microtubule depolymerization, negative regulation of neuron projection development, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of protein phosphorylation, platelet formation, positive regulation of ERK1 and ERK2 cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of catalytic activity, positive regulation of cell adhesion mediated by integrin, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cell population proliferation, positive regulation of cell-matrix adhesion, positive regulation of male germ cell proliferation, positive regulation of protein localization to plasma membrane, positive regulation of protein phosphorylation, positive regulation of protein serine/threonine kinase activity, positive regulation of protein targeting to membrane, positive regulation of substrate adhesion-dependent cell spreading, regulation of cell division, regulation of cell population proliferation, response to ischemia, spermatid development, spermatogenesis, thrombopoietin-mediated signaling pathway; MF: calcium ion binding, calcium-dependent protein kinase inhibitor activity, magnesium ion binding, metal ion binding, protein binding, protein kinase binding, protein serine/threonine kinase inhibitor activity, protein-membrane adaptor activity, small GTPase binding, transmembrane transporter binding; CC: apical plasma membrane, axon, cell periphery, cell projection, centrosome, cytoplasm, cytoskeleton, dendrite, endoplasmic reticulum, filopodium tip, growth cone, lamellipodium, membrane, neuron projection, neuronal cell body, nuclear body, nucleoplasm, nucleus, perikaryon, perinuclear region of cytoplasm, plasma membrane, ruffle membrane, sarcolemma
Pathways:
UniProt: Q9Z0F4
Entrez ID: 23991
|
Does Knockout of Rbm6 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Rbm6
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Rbm6 (RNA binding motif protein 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: S4R1W5, Q3ULB0, S4R1I5, S4R1D1, A0A0A6YWN4, A0A0A6YXE2, A0A0A6YY54
Entrez ID: 19654
|
Does Knockout of Gcat in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Gcat
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Gcat (glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-threonine catabolic process, L-threonine catabolic process to glycine, biological_process; MF: 5-aminolevulinate synthase activity, acyltransferase activity, glycine C-acetyltransferase activity, molecular_function, pyridoxal phosphate binding, transferase activity; CC: cytoplasm, mitochondrial inner membrane, mitochondrion, nuclear speck, nucleoplasm, nucleus
Pathways: Glycine, serine and threonine metabolism - Mus musculus (mouse)
UniProt: O88986
Entrez ID: 26912
|
Does Knockout of Rps6kb1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Rps6kb1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Rps6kb1 (ribosomal protein S6 kinase, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, TOR signaling, TORC1 signaling, TORC2 signaling, apoptotic process, autophagosome assembly, behavioral fear response, cellular response to dexamethasone stimulus, cellular response to growth factor stimulus, cellular response to hormone stimulus, cellular response to insulin stimulus, cellular response to nutrient, cellular response to nutrient levels, cellular response to type II interferon, cytoplasmic translation, germ cell development, insulin receptor signaling pathway, long-chain fatty acid import into cell, modulation of chemical synaptic transmission, negative regulation of TORC1 signaling, negative regulation of TORC2 signaling, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of insulin receptor signaling pathway, peptidyl-serine phosphorylation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of mitotic cell cycle, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of skeletal muscle tissue growth, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of translation, positive regulation of translational initiation, regulation of D-glucose import, regulation of translation, response to glucocorticoid, response to insulin, response to ketone, response to nutrient levels, response to other organism, response to tumor necrosis factor, signal transduction, ubiquitin-dependent protein catabolic process; MF: ATP binding, PDZ domain binding, identical protein binding, kinase activity, nucleotide binding, peptide binding, protein binding, protein kinase activity, protein phosphatase 2A binding, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, ribosomal protein S6 kinase activity, transferase activity; CC: cell surface, cytoplasm, glutamatergic synapse, membrane, mitochondrial outer membrane, mitochondrion, neuron projection, nucleoplasm, nucleus, perinuclear region of cytoplasm, postsynapse, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MTOR signalling, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signal Transduction, TGF-beta signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q8BSK8
Entrez ID: 72508
|
Does Knockout of Gapdh in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Gapdh
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gapdh (glyceraldehyde-3-phosphate dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, apoptotic process, canonical glycolysis, cellular response to type II interferon, defense response to fungus, gluconeogenesis, glucose metabolic process, glyceraldehyde-3-phosphate biosynthetic process, glycolytic process, immune system process, innate immune response, killing by host of symbiont cells, killing of cells of another organism, microtubule cytoskeleton organization, negative regulation of translation, neuron apoptotic process, peptidyl-cysteine S-trans-nitrosylation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cytokine production, positive regulation of type I interferon production, protein stabilization, regulation of translation; MF: NAD binding, NADP binding, aspartic-type endopeptidase inhibitor activity, disordered domain specific binding, enzyme binding, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, identical protein binding, microtubule binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, peptidyl-cysteine S-nitrosylase activity, protein binding, transferase activity; CC: GAIT complex, cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, late endosome lumen, lipid droplet, microtubule cytoskeleton, mitochondrion, myelin sheath, nuclear membrane, nucleus, plasma membrane, postsynaptic density, intracellular component, ribonucleoprotein complex
Pathways: Alzheimer disease - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Salmonella infection - Mus musculus (mouse), gluconeogenesis I, glycolysis I, glycolysis III
UniProt: P16858
Entrez ID: 14433
|
Does Knockout of Zfp706 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Zfp706
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Zfp706 (zinc finger protein 706)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of stem cell population maintenance, regulation of translation; MF: metal ion binding, molecular_function, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q9D115
Entrez ID: 68036
|
Does Knockout of Sowaha in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Sowaha
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sowaha (sosondowah ankyrin repeat domain family member A)
Type: protein-coding
Summary: Is expressed in brain; liver lobe; and sensory organ. Orthologous to human SOWAHA (sosondowah ankyrin repeat domain family member A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q8BLS7
Entrez ID: 237761
|
Does Knockout of Mrfap1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Mrfap1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mrfap1 (Morf4 family associated protein 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be located in nucleoplasm. Is expressed in brain; genitourinary system; liver; lung; and spleen. Orthologous to several human genes including MRFAP1 (Morf4 family associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: identical protein binding, protein binding; CC: cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q9CQL7
Entrez ID: 67568
|
Does Knockout of Ccnc in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Ccnc
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Ccnc (cyclin C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G0 to G1 transition, negative regulation of Notch signaling pathway, negative regulation of triglyceride metabolic process, positive regulation of transcription by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II; MF: cyclin-dependent protein serine/threonine kinase regulator activity, identical protein binding, ubiquitin protein ligase activity; CC: CKM complex, cyclin-dependent protein kinase holoenzyme complex, mediator complex, nucleoplasm, nucleus, protein-containing complex, ubiquitin ligase complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: Q62447
Entrez ID: 51813
|
Does Knockout of Paf1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Paf1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Paf1 (Paf1, RNA polymerase II complex component)
Type: protein-coding
Summary: Enables chromatin binding activity. Involved in several processes, including cellular response to lipopolysaccharide; endodermal cell fate commitment; and negative regulation of transcription by RNA polymerase II. Part of Cdc73/Paf1 complex. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human PAF1 (PAF1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, cellular response to lipopolysaccharide, endodermal cell fate commitment, mRNA 3'-end processing, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of cell cycle G1/S phase transition, positive regulation of transcription by RNA polymerase II, protein localization to nucleus, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, chromatin binding, protein binding; CC: Cdc73/Paf1 complex, cytoplasm, fibrillar center, membrane, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q8K2T8
Entrez ID: 54624
|
Does Knockout of Cd2bp2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Cd2bp2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cd2bp2 (CD2 cytoplasmic tail binding protein 2)
Type: protein-coding
Summary: Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of U5 snRNP. Predicted to colocalize with nuclear speck. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; immune system; and lung. Orthologous to human CD2BP2 (CD2 cytoplasmic tail binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing; MF: ribonucleoprotein complex binding; CC: U5 snRNP, cytoplasm, cytosol, fibrillar center, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q9CWK3
Entrez ID: 70233
|
Does Knockout of Gnal in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Gnal
|
cell cycle progression
|
breast epithelium
|
Gene: Gnal (guanine nucleotide binding protein, alpha stimulating, olfactory type)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, cellular response to dopamine, regulation of long-term synaptic depression, response to amphetamine, response to caffeine, sensory perception of chemical stimulus, sensory perception of smell, signal transduction; MF: G protein activity, G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, guanyl nucleotide binding, hydrolase activity, metal ion binding, nucleotide binding; CC: acrosomal vesicle, apical cytoplasm, ciliary necklace, cilium, cytoplasm, heterotrimeric G-protein complex, membrane, plasma membrane, sperm midpiece
Pathways: Activation of GABAB receptors, Adenylate cyclase activating pathway, Adenylate cyclase inhibitory pathway, Amoebiasis - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), G alpha (i) signalling events, G-protein mediated events, GABA B receptor activation, GABA receptor activation, GPCR downstream signalling, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Olfactory Signaling Pathway, Olfactory transduction - Mus musculus (mouse), Opioid Signalling, Parkinson disease - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by GPCR, Transmission across Chemical Synapses
UniProt: Q8CGK7
Entrez ID: 14680
|
Does Knockout of Tmem88 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Tmem88
|
response to virus
|
Microglial Cell Line
|
Gene: Tmem88 (transmembrane protein 88)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, protein localization to plasma membrane, protein stabilization; MF: PDZ domain binding, protein binding; CC: cytosol, membrane, plasma membrane
Pathways:
UniProt: Q9D0N8
Entrez ID: 67020
|
Does Knockout of Inca1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Inca1
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Inca1 (inhibitor of CDK, cyclin A1 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic signaling pathway, negative regulation of cell population proliferation, negative regulation of fibroblast proliferation, positive regulation of apoptotic signaling pathway; MF: cyclin binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, identical protein binding, protein binding, protein kinase inhibitor activity, protein-containing complex binding; CC: cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q6PKN7
Entrez ID: 103844
|
Does Knockout of Rgs3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Rgs3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rgs3 (regulator of G-protein signaling 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, negative regulation of signal transduction; MF: GTPase activator activity; CC: cytoplasm, membrane, nucleus, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q9DC04
Entrez ID: 50780
|
Does Knockout of Alkbh7 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Alkbh7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Alkbh7 (alkB homolog 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, fatty acid metabolic process, oxidative RNA demethylation, programmed cell death, regulation of lipid storage, regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; MF: dioxygenase activity, metal ion binding, oxidative RNA demethylase activity, oxidoreductase activity, tRNA demethylase activity; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q9D6Z0
Entrez ID: 66400
|
Does Knockout of Npy4r in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Npy4r
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Npy4r (neuropeptide Y receptor Y4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity, neuropeptide binding, pancreatic polypeptide receptor activity, peptide YY receptor activity, peptide binding; CC: membrane, neuron projection, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q61041
Entrez ID: 19065
|
Does Knockout of Psapl1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Psapl1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Psapl1 (prosaposin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, epithelial cell differentiation involved in prostate gland development, lipid metabolic process, prostate gland growth, regulation of lipid metabolic process, sphingolipid metabolic process; CC: cytoplasm, cytosol, extracellular region, extracellular space, lysosome, membrane
Pathways: Lysosome - Mus musculus (mouse), Sphingolipid metabolism - Mus musculus (mouse)
UniProt: Q8C1C1
Entrez ID: 76943
|
Does Knockout of Pcdhb5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Pcdhb5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcdhb5 (protocadherin beta 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8CEA8, Q91XZ5
Entrez ID: 93876
|
Does Knockout of Sned1 in cardiac muscle cell line causally result in protein/peptide accumulation?
| 0
| 1,662
|
Knockout
|
Sned1
|
protein/peptide accumulation
|
cardiac muscle cell line
|
Gene: Sned1 (sushi, nidogen and EGF-like domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell-matrix adhesion; MF: Notch binding, calcium ion binding, molecular_function; CC: extracellular matrix, extracellular region
Pathways:
UniProt: Q70E20
Entrez ID: 208777
|
Does Knockout of Irf1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Irf1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Irf1 (interferon regulatory factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, alpha-beta T cell differentiation, apoptotic process, canonical NF-kappaB signal transduction, cellular response to interferon-beta, cellular response to interleukin-1, cellular response to mechanical stimulus, cellular response to peptide hormone stimulus, cellular response to tumor necrosis factor, defense response to virus, immune system process, innate immune response, negative regulation of DNA-templated transcription, negative regulation of T-helper 2 cell differentiation, negative regulation of regulatory T cell differentiation, positive regulation of DNA-templated transcription, positive regulation of T-helper 1 cell differentiation, positive regulation of apoptotic process, positive regulation of interferon-beta production, positive regulation of interleukin-12 production, positive regulation of natural killer cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of type I interferon production, regulation of CD8-positive, alpha-beta T cell proliferation, regulation of DNA-templated transcription, regulation of MyD88-dependent toll-like receptor signaling pathway, regulation of adaptive immune response, regulation of cell cycle, regulation of gene expression, regulation of innate immune response, regulation of transcription by RNA polymerase II, response to growth hormone, toll-like receptor 3 signaling pathway, type II interferon-mediated signaling pathway; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, nucleus
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: P15314
Entrez ID: 16362
|
Does Knockout of Ctdsp2 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Ctdsp2
|
response to bacteria
|
renal medulla cell line
|
Gene: Ctdsp2 (CTD small phosphatase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of G1/S transition of mitotic cell cycle, regulation of transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat phosphatase activity, hydrolase activity, metal ion binding, phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cellular_component, nucleus
Pathways:
UniProt: Q8BX07
Entrez ID: 52468
|
Does Knockout of Agpat1 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 1,521
|
Knockout
|
Agpat1
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Agpat1 (1-acylglycerol-3-phosphate O-acyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, lipid metabolic process, phosphatidic acid biosynthetic process, phospholipid biosynthetic process, positive regulation of cytokine production; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, Fat digestion and absorption - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PA, phosphatidylglycerol biosynthesis I (plastidic), phosphatidylglycerol biosynthesis II (non-plastidic), phospholipid biosynthesis I, triacylglycerol biosynthesis
UniProt: O35083
Entrez ID: 55979
|
Does Knockout of Bahd1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Bahd1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Bahd1 (bromo adjacent homology domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, heterochromatin formation, negative regulation of DNA-templated transcription; MF: chromatin binding, transcription cis-regulatory region binding; CC: chromatin silencing complex, chromosome, nucleoplasm, nucleus
Pathways:
UniProt: Z4YMJ8, Z4YJL0
Entrez ID: 228536
|
Does Knockout of Mrpl40 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Mrpl40
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mrpl40 (mitochondrial ribosomal protein L40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, nucleolus, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9Z2Q5
Entrez ID: 18100
|
Does Knockout of Rps15a in small cell lung cancer causally result in cell proliferation?
| 1
| 1,714
|
Knockout
|
Rps15a
|
cell proliferation
|
small cell lung cancer
|
Gene: Rps15a (ribosomal protein S15A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, positive regulation of cell cycle, positive regulation of cell population proliferation, response to virus, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, mitochondrion, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62245
Entrez ID: 267019
|
Does Knockout of Tmprss11e in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Tmprss11e
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tmprss11e (transmembrane protease, serine 11e)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cognition, proteolysis; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: Q5S248
Entrez ID: 243084
|
Does Knockout of Ogfr in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Ogfr
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ogfr (opioid growth factor receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: opioid growth factor receptor activity, signaling receptor activity; CC: cytoplasm, membrane, nucleus
Pathways:
UniProt: Q99PG2
Entrez ID: 72075
|
Does Knockout of Rad51c in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,539
|
Knockout
|
Rad51c
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rad51c (RAD51 paralog C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, double-strand break repair via homologous recombination, female meiosis sister chromatid cohesion, male meiosis I, meiotic DNA recombinase assembly, positive regulation of G2/M transition of mitotic cell cycle, reciprocal meiotic recombination, sister chromatid cohesion, spermatogenesis, telomere maintenance via recombination; MF: ATP binding, ATP-dependent DNA damage sensor activity, DNA binding, crossover junction DNA endonuclease activity, four-way junction DNA binding, nucleotide binding, protein binding; CC: Holliday junction resolvase complex, Rad51B-Rad51C-Rad51D-XRCC2 complex, Rad51C-XRCC3 complex, cell junction, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, perinuclear region of cytoplasm, replication fork
Pathways: DNA Double-Strand Break Repair, DNA Repair, Factors involved in megakaryocyte development and platelet production, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hemostasis, Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Presynaptic phase of homologous DNA pairing and strand exchange, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q924H5
Entrez ID: 114714
|
Does Knockout of Fcrl1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Fcrl1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Fcrl1 (Fc receptor-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: coreceptor activity, protein phosphatase binding, signaling adaptor activity; CC: cell surface, membrane, plasma membrane
Pathways:
UniProt: Q8R4Y0
Entrez ID: 229499
|
Does Knockout of Zranb1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Zranb1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zranb1 (zinc finger, RAN-binding domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, autophagosome assembly, cell migration, cytoskeleton organization, phosphatidylinositol phosphate biosynthetic process, positive regulation of Wnt signaling pathway, protein K29-linked deubiquitination, protein K33-linked deubiquitination, protein K63-linked deubiquitination, protein deubiquitination, protein deubiquitination involved in ubiquitin-dependent protein catabolic process, proteolysis, regulation of cell morphogenesis; MF: K63-linked polyubiquitin modification-dependent protein binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, metal ion binding, peptidase activity, polyubiquitin modification-dependent protein binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Degradation of beta-catenin by the destruction complex, Deubiquitination, Metabolism of proteins, Ovarian tumor domain proteases, Post-translational protein modification, Signal Transduction, Signaling by WNT
UniProt: Q7M760
Entrez ID: 360216
|
Does Knockout of Ggps1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,261
|
Knockout
|
Ggps1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ggps1 (geranylgeranyl diphosphate synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: farnesyl diphosphate biosynthetic process, geranyl diphosphate biosynthetic process, geranylgeranyl diphosphate biosynthetic process, isoprenoid biosynthetic process, isoprenoid metabolic process, lipid metabolic process; MF: (2E,6E)-farnesyl diphosphate synthase activity, dimethylallyltranstransferase activity, geranylgeranyl diphosphate synthase activity, identical protein binding, metal ion binding, prenyl diphosphate synthase activity, prenyltransferase activity, transferase activity; CC: Z disc, cytoplasm, cytosol, nucleoplasm, perinuclear region of cytoplasm
Pathways: <i>trans, trans</i>-farnesyl diphosphate biosynthesis, Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, Terpenoid backbone biosynthesis - Mus musculus (mouse), superpathway of cholesterol biosynthesis
UniProt: Q9WTN0
Entrez ID: 14593
|
Does Knockout of Smarcd1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 1
| 2,181
|
Knockout
|
Smarcd1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Smarcd1 (SWI/SNF related BAF chromatin remodeling complex subunit D1)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity; signaling receptor binding activity; and transcription coregulator activity. Predicted to be involved in nucleosome disassembly; regulation of transcription by RNA polymerase II; and transcription initiation-coupled chromatin remodeling. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and retina layer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 11. Orthologous to human SMARCD1 (SWI/SNF related BAF chromatin remodeling complex subunit D1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to fatty acid, chromatin organization, chromatin remodeling, negative regulation of cell differentiation, nervous system development, nucleosome disassembly, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription initiation-coupled chromatin remodeling; MF: chromatin binding, molecular adaptor activity, protein binding, signaling receptor binding, transcription coregulator activity; CC: GBAF complex, RSC-type complex, SWI/SNF complex, brahma complex, chromatin, kinetochore, nBAF complex, npBAF complex, nuclear matrix, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin modifying enzymes, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SWI/SNF chromatin remodelers, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: Q61466
Entrez ID: 83797
|
Does Knockout of Cox6b2 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Cox6b2
|
phagocytosis
|
macrophage
|
Gene: Cox6b2 (cytochrome c oxidase subunit 6B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, oxidative phosphorylation; CC: membrane, mitochondrial crista, mitochondrial inner membrane, mitochondrion, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: Q80ZN9
Entrez ID: 333182
|
Does Knockout of Atat1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Atat1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Atat1 (alpha tubulin acetyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-tubulin acetylation, dentate gyrus development, microtubule cytoskeleton organization, neuron development, positive regulation of NLRP3 inflammasome complex assembly, regulation of fat cell differentiation, regulation of microtubule cytoskeleton organization, response to mechanical stimulus, response to pain, spermatogenesis; MF: L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, acetyltransferase activity, acyltransferase activity, transferase activity, tubulin N-acetyltransferase activity; CC: Golgi apparatus, anchoring junction, axon, cell projection, clathrin-coated pit, cytoplasm, cytoskeleton, cytosol, focal adhesion, membrane, microtubule, microtubule bundle, mitotic spindle, spindle
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8K341
Entrez ID: 73242
|
Does Knockout of Stip1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Stip1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Stip1 (stress-induced phosphoprotein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: Hsp70 protein binding, Hsp90 protein binding, protein binding, protein-folding chaperone binding; CC: cytoplasm, cytosol, dynein axonemal particle, myelin sheath, nucleus, protein folding chaperone complex, protein-containing complex
Pathways: Cellular responses to stimuli, Cellular responses to stress, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Prion disease - Mus musculus (mouse), RHO GTPase cycle, RND1 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q60864
Entrez ID: 20867
|
Does Knockout of Psmd11 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Psmd11
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Psmd11 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome assembly, stem cell differentiation, ubiquitin-dependent protein catabolic process; MF: protein binding, structural molecule activity; CC: proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q8BG32
Entrez ID: 69077
|
Does Knockout of Prrt2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Prrt2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prrt2 (proline-rich transmembrane protein 2)
Type: protein-coding
Summary: Enables syntaxin-1 binding activity. Involved in negative regulation of short-term synaptic potentiation; regulation of vesicle fusion; and synaptic vesicle fusion to presynaptic active zone membrane. Located in axon terminus; plasma membrane; and synaptic vesicle. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in brain and spinal cord. Used to study episodic kinesigenic dyskinesia 1. Human ortholog(s) of this gene implicated in benign familial infantile seizures 2 and episodic kinesigenic dyskinesia 1. Orthologous to human PRRT2 (proline rich transmembrane protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of SNARE complex assembly, negative regulation of short-term synaptic potentiation, neuromuscular process controlling posture, regulation of calcium-dependent activation of synaptic vesicle fusion, synaptic vesicle fusion to presynaptic active zone membrane; MF: SH3 domain binding, protein binding, syntaxin-1 binding; CC: axon, axon terminus, cell projection, cytoplasmic vesicle, dendritic spine, glutamatergic synapse, membrane, neuron projection, plasma membrane, postsynaptic density membrane, postsynaptic membrane, presynapse, presynaptic membrane, synapse, synaptic vesicle, synaptic vesicle membrane, vesicle
Pathways:
UniProt: E9PUL5
Entrez ID: 69017
|
Does Knockout of Rabep2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Rabep2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rabep2 (rabaptin, RAB GTPase binding effector protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, endocytosis, protein transport, regulation of cilium assembly, signal transduction; MF: GTPase activator activity, growth factor activity; CC: Golgi apparatus, cell projection, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, early endosome, endosome, intracellular membrane-bounded organelle
Pathways: cyclic AMP biosynthesis
UniProt: Q91WG2
Entrez ID: 70314
|
Does Knockout of Catsper3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Catsper3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Catsper3 (cation channel, sperm associated 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, cell differentiation, establishment of localization in cell, flagellated sperm motility, monoatomic ion transmembrane transport, monoatomic ion transport, sodium ion transport, sperm capacitation, spermatogenesis, transmembrane transport; MF: calcium channel activity, monoatomic ion channel activity, protein binding, voltage-gated calcium channel activity; CC: CatSper complex, acrosomal vesicle, cell projection, cilium, endoplasmic reticulum, membrane, monoatomic ion channel complex, motile cilium, plasma membrane
Pathways: Fertilization, Reproduction, Sperm Motility And Taxes
UniProt: Q80W99
Entrez ID: 76856
|
Does Knockout of Gm5916 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Gm5916
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gm5916 (predicted gene 5916)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: G5E8W5
Entrez ID: 546123
|
Does Knockout of Gstm3 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Gstm3
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Gstm3 (glutathione S-transferase, mu 3)
Type: protein-coding
Summary: Predicted to enable several functions, including glutathione binding activity; glutathione transferase activity; and protein homodimerization activity. Acts upstream of or within cellular response to xenobiotic stimulus and response to bacterium. Predicted to be located in cytosol and intercellular bridge. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1) and GSTM5 (glutathione S-transferase mu 5). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cellular response to xenobiotic stimulus, glutathione metabolic process, response to bacterium; MF: enzyme binding, glutathione binding, glutathione transferase activity, identical protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: P19639
Entrez ID: 14864
|
Does Knockout of Ctxn3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ctxn3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ctxn3 (cortexin 3)
Type: protein-coding
Summary: Predicted to be located in membrane. Is expressed in genitourinary system and otocyst. Orthologous to human CTXN3 (cortexin 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8BXZ0
Entrez ID: 629147
|
Does Knockout of Tmem268 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Tmem268
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Tmem268 (transmembrane protein 268)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q8R239
Entrez ID: 230279
|
Does Knockout of Ears2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Ears2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Ears2 (glutamyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in a similar gene in human have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). [provided by RefSeq, Mar 2015].
Gene Ontology: BP: glutamyl-tRNA aminoacylation, tRNA aminoacylation, tRNA aminoacylation for mitochondrial protein translation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, RNA binding, aminoacyl-tRNA ligase activity, glutamate-tRNA ligase activity, glutamate-tRNA(Gln) ligase activity, ligase activity, nucleotide binding, tRNA binding, zinc ion binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), Porphyrin and chlorophyll metabolism - Mus musculus (mouse), tRNA charging pathway
UniProt: Q9CXJ1
Entrez ID: 67417
|
Does Knockout of Csf2ra in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Csf2ra
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Csf2ra (colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cytokine-mediated signaling pathway, granulocyte-macrophage colony-stimulating factor signaling pathway, positive regulation of leukocyte proliferation; MF: cytokine receptor activity, granulocyte colony-stimulating factor binding, granulocyte colony-stimulating factor receptor activity; CC: granulocyte macrophage colony-stimulating factor receptor complex, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: Q00941
Entrez ID: 12982
|
Does Knockout of Synpo in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Synpo
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Synpo (synaptopodin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cortical cytoskeleton organization, positive regulation of actin filament bundle assembly, postsynaptic modulation of chemical synaptic transmission, regulation of long-term neuronal synaptic plasticity, regulation of postsynaptic cytosolic calcium ion concentration, regulation of stress fiber assembly, spine apparatus assembly, visual learning; MF: actin binding, protein binding; CC: Schaffer collateral - CA1 synapse, Z disc, actin cytoskeleton, anchoring junction, bicellular tight junction, cell periphery, cell projection, cytoplasm, cytoskeleton, cytosol, dendrite, dendritic spine, glutamatergic synapse, nucleus, organelle, perikaryon, plasma membrane, postsynaptic density, spine apparatus, stress fiber, synapse
Pathways: Tight junction - Mus musculus (mouse)
UniProt: Q8CC35
Entrez ID: 104027
|
Does Knockout of Pced1b in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,838
|
Knockout
|
Pced1b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pced1b (PC-esterase domain containing 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BGX1
Entrez ID: 239647
|
Does Knockout of Nkg7 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Nkg7
|
phagocytosis
|
macrophage
|
Gene: Nkg7 (natural killer cell group 7 sequence)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD4-positive, alpha-beta T cell activation, defense response to protozoan, granzyme-mediated programmed cell death signaling pathway, inflammatory response, killing of cells of another organism, natural killer cell degranulation, natural killer cell mediated cytotoxicity, natural killer cell mediated cytotoxicity directed against tumor cell target, positive regulation of inflammatory response; CC: cytolytic granule, cytolytic granule membrane, lysosome, membrane, plasma membrane
Pathways:
UniProt: Q8C2L9, Q9CY55
Entrez ID: 72310
|
Does Knockout of Lats2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Lats2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lats2 (large tumor suppressor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, hippo signaling, hormone-mediated signaling pathway, inner cell mass cell fate commitment, inner cell mass cellular morphogenesis, intracellular protein localization, intracellular signal transduction, keratinocyte differentiation, negative regulation of canonical Wnt signaling pathway, negative regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of protein localization to nucleus, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of apoptotic process, positive regulation of hippo signaling, protein phosphorylation, regulation of organ growth, regulation of transforming growth factor beta receptor signaling pathway; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centriolar satellite, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton, nucleus, spindle pole
Pathways: Hippo signaling pathway - Mus musculus (mouse), Hippo signaling pathway - multiple species - Mus musculus (mouse), Signal Transduction, Signaling by Hippo
UniProt: Q7TSJ6
Entrez ID: 50523
|
Does Knockout of Rap2b in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Rap2b
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Rap2b (RAP2B, member of RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rap protein signal transduction, negative regulation of cell migration, platelet activation, platelet aggregation, regulation of protein tyrosine kinase activity, signal transduction; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein domain specific binding; CC: bicellular tight junction, bounding membrane of organelle, cell-cell contact zone, cytoplasmic vesicle membrane, cytosol, endomembrane system, endosome, extracellular exosome, membrane, membrane raft, plasma membrane, recycling endosome, recycling endosome membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P61226
Entrez ID: 74012
|
Does Knockout of Ptk2b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Ptk2b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ptk2b (PTK2 protein tyrosine kinase 2 beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, MAPK cascade, actin filament organization, adaptive immune response, angiogenesis, blood vessel endothelial cell migration, bone resorption, cell adhesion, cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway, cellular defense response, cellular response to fluid shear stress, cellular response to retinoic acid, chemokine-mediated signaling pathway, cortical cytoskeleton organization, cytoskeleton organization, endothelin receptor signaling pathway, epidermal growth factor receptor signaling pathway, focal adhesion assembly, immune system process, integrin-mediated signaling pathway, ionotropic glutamate receptor signaling pathway, long-term synaptic depression, long-term synaptic potentiation, marginal zone B cell differentiation, negative regulation of apoptotic process, negative regulation of bone mineralization, negative regulation of cell population proliferation, negative regulation of muscle cell apoptotic process, negative regulation of myeloid cell differentiation, negative regulation of neuron apoptotic process, negative regulation of ossification, negative regulation of potassium ion transport, neuron migration, neuron projection development, oocyte maturation, peptidyl-tyrosine phosphorylation, positive regulation of B cell chemotaxis, positive regulation of DNA biosynthetic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of actin filament polymerization, positive regulation of angiogenesis, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell-matrix adhesion, positive regulation of cytosolic calcium ion concentration, positive regulation of endothelial cell migration, positive regulation of excitatory postsynaptic potential, positive regulation of neuron projection development, positive regulation of nitric oxide biosynthetic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein kinase activity, positive regulation of protein metabolic process, positive regulation of reactive oxygen species metabolic process, positive regulation of signal transduction, positive regulation of synaptic transmission, glutamatergic, positive regulation of translation, positive regulation of ubiquitin-dependent protein catabolic process, postsynaptic modulation of chemical synaptic transmission, regulation of actin cytoskeleton organization, regulation of biological quality, regulation of cell adhesion, regulation of cell shape, regulation of macrophage chemotaxis, regulation of postsynaptic density assembly, regulation of release of sequestered calcium ion into cytosol, regulation of ubiquitin-dependent protein catabolic process, response to cation stress, response to hydrogen peroxide, response to ischemia, signal complex assembly, sprouting angiogenesis, stress fiber assembly, tumor necrosis factor-mediated signaling pathway, vascular endothelial growth factor receptor signaling pathway; MF: 3-phosphoinositide-dependent protein kinase binding, ATP binding, calcium/calmodulin-dependent protein kinase activity, enzyme binding, glutamate receptor binding, ionotropic glutamate receptor binding, kinase activity, neurotransmitter receptor regulator activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, protein-containing complex binding, signaling receptor activator activity, transferase activity, ubiquitin protein ligase binding; CC: NMDA selective glutamate receptor complex, Schaffer collateral - CA1 synapse, anchoring junction, apical dendrite, axon, cell body, cell cortex, cell projection, cytoplasm, dendrite, focal adhesion, glutamatergic synapse, growth cone, lamellipodium, membrane, neuronal cell body, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynapse, postsynaptic density, postsynaptic density, intracellular component, presynapse
Pathways: Calcium signaling pathway - Mus musculus (mouse), Cell-Cell communication, Chemokine signaling pathway - Mus musculus (mouse), Cytokine Signaling in Immune system, GnRH signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Interleukin-2 family signaling, Interleukin-2 signaling, Leukocyte transendothelial migration - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), RHO GTPase cycle, RHOU GTPase cycle, Signal Transduction, Signal regulatory protein family interactions, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway, Yersinia infection - Mus musculus (mouse)
UniProt: Q9QVP9
Entrez ID: 19229
|
Does Knockout of Tldc2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Tldc2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tldc2 (TBC/LysM associated domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cellular response to oxidative stress, response to oxidative stress
Pathways:
UniProt: A2ACG1
Entrez ID: 383766
|
Does Knockout of Cfhr1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Cfhr1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cfhr1 (complement factor H-related 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood coagulation, complement activation; MF: complement component C3b binding, identical protein binding; CC: extracellular region, extracellular space, protein-containing complex
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Immune System, Innate Immune System, Regulation of Complement cascade
UniProt: A0A0A6YXP6, Q61406
Entrez ID: 50702
|
Does Knockout of Serpinb9f in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Serpinb9f
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Serpinb9f (serine (or cysteine) peptidase inhibitor, clade B, member 9f)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hematopoietic progenitor cell differentiation, immune response, negative regulation of apoptotic process, protection from natural killer cell mediated cytotoxicity; MF: cysteine-type endopeptidase inhibitor activity involved in apoptotic process, peptidase inhibitor activity, protease binding, serine-type endopeptidase inhibitor activity; CC: Golgi apparatus, cytoplasm, cytosol, extracellular space, nucleoplasm, nucleus
Pathways: Amoebiasis - Mus musculus (mouse)
UniProt: Q80UK5
Entrez ID: 20709
|
Does Knockout of Mrto4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Mrto4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Mrto4 (mRNA turnover 4, ribosome maturation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, rRNA processing, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis; CC: cytoplasm, nucleolus, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q9D0I8
Entrez ID: 69902
|
Does Knockout of Gal3st2b in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Gal3st2b
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Gal3st2b (galactose-3-O-sulfotransferase 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6XQH0
Entrez ID: 100041596
|
Does Knockout of Pfn2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Pfn2
|
response to virus
|
Microglial Cell Line
|
Gene: Pfn2 (profilin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, modification of postsynaptic actin cytoskeleton, modulation of chemical synaptic transmission, negative regulation of actin filament polymerization, negative regulation of epithelial cell migration, negative regulation of ruffle assembly, positive regulation of actin filament bundle assembly, positive regulation of actin filament polymerization, positive regulation of stress fiber assembly, presynaptic actin cytoskeleton organization, presynaptic modulation of chemical synaptic transmission, protein stabilization, regulation of actin filament polymerization, regulation of synaptic vesicle exocytosis; MF: ATP hydrolysis activity, actin binding, actin monomer binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: Schaffer collateral - CA1 synapse, cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, postsynapse, presynapse, terminal bouton
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Axon guidance, Developmental Biology, Nervous system development, RHO GTPase Effectors, RHO GTPases Activate Formins, Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9JJV2
Entrez ID: 18645
|
Does Knockout of Dynlrb1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Dynlrb1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Dynlrb1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule-based movement, visual behavior; MF: dynein intermediate chain binding, identical protein binding, protein binding; CC: centrosome, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, microtubule
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance, Salmonella infection - Mus musculus (mouse)
UniProt: P62627
Entrez ID: 67068
|
Does Knockout of Adrb1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Adrb1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Adrb1 (adrenergic receptor, beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho protein signal transduction, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating adrenergic receptor signaling pathway, brown fat cell differentiation, diet induced thermogenesis, fear response, glycogen catabolic process, heat generation, inhibitory postsynaptic potential, lipid homeostasis, memory, negative regulation of multicellular organism growth, negative regulation of smooth muscle contraction, negative regulation of urine volume, norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure, positive regulation of MAPK cascade, positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, positive regulation of apoptotic process, positive regulation of calcium ion import across plasma membrane, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of cold-induced thermogenesis, positive regulation of heart contraction, positive regulation of heart rate, positive regulation of heart rate by epinephrine-norepinephrine, positive regulation of long-term synaptic potentiation, positive regulation of systemic arterial blood pressure, positive regulation of the force of heart contraction by epinephrine-norepinephrine, positive regulation of the force of heart contraction by norepinephrine, regulation of calcium ion transport, regulation of cardiac muscle cell contraction, regulation of circadian sleep/wake cycle, sleep, regulation of postsynaptic membrane potential, regulation of system process, response to cold, signal transduction; MF: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential, G protein-coupled receptor activity, PDZ domain binding, adrenergic receptor activity, alpha-2A adrenergic receptor binding, amine binding, beta-adrenergic receptor activity, beta1-adrenergic receptor activity, protein binding, protein heterodimerization activity; CC: Schaffer collateral - CA1 synapse, early endosome, endosome, membrane, neuronal dense core vesicle, plasma membrane
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Adrenoceptors, Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Dilated cardiomyopathy - Mus musculus (mouse), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Gap junction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P34971
Entrez ID: 11554
|
Does Knockout of Ccdc18 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Ccdc18
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ccdc18 (coiled-coil domain containing 18)
Type: protein-coding
Summary: Predicted to be located in centriolar satellite. Orthologous to human CCDC18 (coiled-coil domain containing 18). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, positive regulation of adipose tissue development; CC: cellular_component, centriolar satellite, cytoplasm, cytoskeleton
Pathways:
UniProt: Q640L5
Entrez ID: 73254
|
Does Knockout of Esco1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Esco1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Esco1 (establishment of sister chromatid cohesion N-acetyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitotic sister chromatid cohesion, peptidyl-lysine acetylation, post-translational protein acetylation, regulation of DNA replication; MF: N-acetyltransferase activity, acetyltransferase activity, acyltransferase activity, identical protein binding, metal ion binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Establishment of Sister Chromatid Cohesion, S Phase
UniProt: Q69Z69
Entrez ID: 77805
|
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