prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Chsy1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Chsy1
|
cell proliferation
|
Regulatory T cell
|
Gene: Chsy1 (chondroitin sulfate synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone morphogenesis, cartilage development, chondrocyte development, chondroitin sulfate proteoglycan biosynthetic process, negative regulation of ossification, positive regulation of smoothened signaling pathway, proximal/distal pattern formation, response to nutrient levels, sulfation; MF: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity, acetylgalactosaminyltransferase activity, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, glycosyltransferase activity, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, extracellular region, membrane
Pathways: CS-GAG biosynthesis, Chondroitin sulfate/dermatan sulfate metabolism, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, chondroitin and dermatan biosynthesis, chondroitin sulfate biosynthesis, chondroitin sulfate biosynthesis (late stages), dermatan sulfate biosynthesis
UniProt: Q6ZQ11
Entrez ID: 269941
|
Does Knockout of Cd46 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Cd46
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cd46 (CD46 antigen, complement regulatory protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell mediated immunity, negative regulation of complement activation, classical pathway, negative regulation of gene expression, positive regulation of T cell proliferation, positive regulation of gene expression, positive regulation of interleukin-10 production, positive regulation of memory T cell differentiation, positive regulation of proteolysis, positive regulation of regulatory T cell differentiation, positive regulation of transforming growth factor beta production, regulation of Notch signaling pathway, sequestering of extracellular ligand from receptor, single fertilization; MF: cadherin binding, endopeptidase activity; CC: acrosomal vesicle, basolateral plasma membrane, cell surface, cytoplasmic vesicle, extracellular region, extracellular space, inner acrosomal membrane, membrane, plasma membrane
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Immune System, Innate Immune System, Measles - Mus musculus (mouse), Regulation of Complement cascade
UniProt: O88174
Entrez ID: 17221
|
Does Knockout of Copz2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Copz2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Copz2 (coatomer protein complex, subunit zeta 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intra-Golgi vesicle-mediated transport, intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; CC: COPI vesicle coat, COPI-coated vesicle, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9JHH9
Entrez ID: 56358
|
Does Knockout of Letm1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Letm1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Letm1 (leucine zipper-EF-hand containing transmembrane protein 1)
Type: protein-coding
Summary: Enables calcium:proton antiporter activity. Involved in calcium export from the mitochondrion; mitochondrial calcium ion homeostasis; and protein complex oligomerization. Located in mitochondrial inner membrane. Is expressed in brain; embryo; gonad; liver; and seminiferous cord. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: calcium export from the mitochondrion, calcium ion transport, cristae formation, inner mitochondrial membrane organization, mitochondrial calcium ion homeostasis, mitochondrial calcium ion transmembrane transport, mitochondrial potassium ion transmembrane transport, mitochondrion organization, monoatomic ion transport, negative regulation of mitochondrial calcium ion concentration, potassium ion transport, protein hexamerization, protein homooligomerization, proton transmembrane transport, regulation of cellular hyperosmotic salinity response; MF: antiporter activity, calcium:proton antiporter activity, metal ion binding, ribosome binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: RHO GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Z2I0
Entrez ID: 56384
|
Does Knockout of Idh2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Idh2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial)
Type: protein-coding
Summary: Enables isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in several processes, including NADP biosynthetic process; carboxylic acid metabolic process; and negative regulation of matrix metallopeptidase secretion. Located in cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study bone remodeling disease. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: 2-oxoglutarate metabolic process, NADP+ biosynthetic process, NADP+ metabolic process, glyoxylate cycle, isocitrate metabolic process, negative regulation of glial cell migration, negative regulation of glial cell proliferation, negative regulation of matrix metallopeptidase secretion, tricarboxylic acid cycle; MF: NAD binding, isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: cytosol, mitochondrial inner membrane, mitochondrion, peroxisome
Pathways: Aerobic respiration and respiratory electron transport, Central carbon metabolism in cancer - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Glutathione metabolism - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Metabolism of proteins, Mitochondrial biogenesis, Mitochondrial protein degradation, Organelle biogenesis and maintenance, Peroxisome - Mus musculus (mouse), TCA cycle, Transcriptional activation of mitochondrial biogenesis
UniProt: P54071
Entrez ID: 269951
|
Does Knockout of Zfp964 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Zfp964
|
cell cycle progression
|
breast epithelium
|
Gene: Zfp964 (zinc finger protein 964)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: B2RR88
Entrez ID: 636741
|
Does Knockout of Unc13a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Unc13a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Unc13a (unc-13 homolog A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SNARE complex assembly, amyloid-beta metabolic process, cell differentiation, chemical synaptic transmission, dense core granule docking, dense core granule priming, exocytosis, innervation, long-term synaptic potentiation, neuromuscular junction development, neuronal dense core vesicle exocytosis, neurotransmitter secretion, positive regulation of dendrite extension, positive regulation of glutamate receptor signaling pathway, positive regulation of neurotransmitter secretion, positive regulation of synaptic plasticity, positive regulation of vesicle fusion, regulation of amyloid precursor protein catabolic process, regulation of calcium-dependent activation of synaptic vesicle fusion, regulation of short-term neuronal synaptic plasticity, regulation of synaptic vesicle priming, synaptic transmission, glutamatergic, synaptic vesicle docking, synaptic vesicle exocytosis, synaptic vesicle maturation, synaptic vesicle priming; MF: SNARE binding, calcium ion binding, calmodulin binding, diacylglycerol binding, identical protein binding, metal ion binding, phospholipid binding, protein binding, protein domain specific binding, protein-containing complex binding, spectrin binding, syntaxin binding, syntaxin-1 binding, zinc ion binding; CC: Golgi-associated vesicle, axon, calyx of Held, cell projection, cytoplasm, excitatory synapse, glutamatergic synapse, membrane, neuromuscular junction, neuron projection, plasma membrane, presynapse, presynaptic active zone, presynaptic membrane, protein-containing complex, synapse, synaptic membrane, synaptic vesicle membrane, terminal bouton
Pathways: Synaptic vesicle cycle - Mus musculus (mouse)
UniProt: Q4KUS2
Entrez ID: 382018
|
Does Knockout of 4833420G17Rik in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
4833420G17Rik
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: 4833420G17Rik (RIKEN cDNA 4833420G17 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UJC8
Entrez ID: 67392
|
Does Knockout of Egr2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Egr2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Egr2 (early growth response 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell differentiation, aorta development, brain segmentation, facial nerve structural organization, fat cell differentiation, gene expression, motor neuron axon guidance, myelination, positive regulation of DNA-templated transcription, positive regulation of Schwann cell differentiation, positive regulation of myelination, positive regulation of transcription by RNA polymerase II, protein export from nucleus, protein sumoylation, regulation of DNA-templated transcription, regulation of ossification, regulation of transcription by RNA polymerase II, response to insulin, rhombomere 3 development, rhombomere 3 formation, rhombomere 3 structural organization, rhombomere 5 formation, rhombomere 5 structural organization, rhythmic behavior, skeletal muscle cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, HMG box domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, SUMO ligase activity, chromatin binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transferase activity, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), NGF-stimulated transcription, Nuclear Events (kinase and transcription factor activation), Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Viral carcinogenesis - Mus musculus (mouse)
UniProt: P08152
Entrez ID: 13654
|
Does Knockout of Gm21734 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Gm21734
|
phagocytosis
|
macrophage
|
Gene: Gm21734 (predicted gene, 21734)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of M6pr in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
M6pr
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: M6pr (mannose-6-phosphate receptor, cation dependent)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, lysosomal transport, protein targeting to lysosome, secretion of lysosomal enzymes; MF: protein binding, protein domain specific binding, retromer complex binding; CC: Golgi apparatus, cytoplasm, endomembrane system, endosome, late endosome, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm, trans-Golgi network
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Intra-Golgi and retrograde Golgi-to-ER traffic, Lysosome - Mus musculus (mouse), Lysosome Vesicle Biogenesis, Membrane Trafficking, Metabolism, Metabolism of lipids, Phagosome - Mus musculus (mouse), Retrograde transport at the Trans-Golgi-Network, Salmonella infection - Mus musculus (mouse), Sphingolipid metabolism, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: P24668
Entrez ID: 17113
|
Does Knockout of Prr19 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Prr19
|
cell proliferation
|
Regulatory T cell
|
Gene: Prr19 (proline rich 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, meiotic cell cycle; CC: chromosome, nucleus
Pathways:
UniProt: B2RW88
Entrez ID: 623131
|
Does Knockout of Alkbh7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Alkbh7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Alkbh7 (alkB homolog 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, fatty acid metabolic process, oxidative RNA demethylation, programmed cell death, regulation of lipid storage, regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; MF: dioxygenase activity, metal ion binding, oxidative RNA demethylase activity, oxidoreductase activity, tRNA demethylase activity; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q9D6Z0
Entrez ID: 66400
|
Does Knockout of Pla2g4d in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Pla2g4d
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Pla2g4d (phospholipase A2, group IVD)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, glycerophospholipid catabolic process, lipid catabolic process, lipid metabolic process, phospholipid catabolic process; MF: calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding, hydrolase activity, metal ion binding, phospholipase A2 activity, phospholipase activity; CC: cytoplasm, cytosol, membrane
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PG, Acyl chain remodelling of PI, Acyl chain remodelling of PS, Arachidonic acid metabolism - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Ether lipid metabolism - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Hydrolysis of LPC, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of lipids, Necroptosis - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Platelet activation - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Synthesis of PA, VEGF signaling pathway - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), phospholipases
UniProt: Q50L43
Entrez ID: 78390
|
Does Knockout of Kctd5 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Kctd5
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Kctd5 (potassium channel tetramerisation domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein homooligomerization; MF: cullin family protein binding, identical protein binding, protein binding, protein-containing complex binding; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8VC57
Entrez ID: 69259
|
Does Knockout of Flrt3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Flrt3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Flrt3 (fibronectin leucine rich transmembrane protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, embryonic morphogenesis, fibroblast growth factor receptor signaling pathway, head development, heart development, negative chemotaxis, neuron projection development, neuron projection extension, positive regulation of synapse assembly, proepicardium cell migration involved in pericardium morphogenesis, response to axon injury, synapse assembly, synaptic membrane adhesion; MF: chemorepellent activity, fibroblast growth factor receptor binding, protein binding, protein homodimerization activity; CC: anchoring junction, axon, axon terminus, axonal growth cone, cell junction, cell projection, cell-cell junction, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular region, extracellular space, focal adhesion, glutamatergic synapse, growth cone membrane, membrane, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse, synaptic membrane
Pathways: Downstream signaling of activated FGFR1, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by Receptor Tyrosine Kinases
UniProt: Q8BGT1
Entrez ID: 71436
|
Does Knockout of Nyx in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Nyx
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nyx (nyctalopin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: visual perception; MF: protein binding, signaling receptor activity; CC: dendrite, extracellular matrix, extracellular region, postsynapse
Pathways:
UniProt: P83503
Entrez ID: 236690
|
Does Knockout of Msantd3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Msantd3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Msantd3 (Myb/SANT-like DNA-binding domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9CR78
Entrez ID: 66665
|
Does Knockout of Smtn in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Smtn
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Smtn (smoothelin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of systemic arterial blood pressure, positive regulation of cardiac muscle contraction; CC: cytoplasm, cytoskeleton
Pathways:
UniProt: Q921U8
Entrez ID: 29856
|
Does Knockout of Uqcr11 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Uqcr11
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Uqcr11 (ubiquinol-cytochrome c reductase, complex III subunit XI)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex III
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CPX8
Entrez ID: 66594
|
Does Knockout of Cnbd2 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Cnbd2
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Cnbd2 (cyclic nucleotide binding domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: spermatogenesis; MF: cAMP binding, nucleotide binding; CC: cytoplasm, cytosol
Pathways:
UniProt: Q9D5U8
Entrez ID: 70873
|
Does Knockout of Gadd45gip1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,266
|
Knockout
|
Gadd45gip1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gadd45gip1 (growth arrest and DNA-damage-inducible, gamma interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CR59
Entrez ID: 102060
|
Does Knockout of Capn10 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Capn10
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Capn10 (calpain 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy of mitochondrion, cellular response to insulin stimulus, mitochondrion organization, positive regulation of D-glucose import, positive regulation of apoptotic process, positive regulation of insulin secretion, positive regulation of type B pancreatic cell apoptotic process, protein catabolic process, proteolysis, regulation of actin cytoskeleton organization, response to nutrient levels, type B pancreatic cell apoptotic process, vesicle-mediated transport to the plasma membrane; MF: SNARE binding, calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity, cytoskeletal protein binding, hydrolase activity, peptidase activity; CC: cytoplasm, cytoskeleton, cytosol, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial outer membrane, mitochondrion, plasma membrane
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization
UniProt: Q9ESK3
Entrez ID: 23830
|
Does Knockout of C2cd4c in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
C2cd4c
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: C2cd4c (C2 calcium-dependent domain containing 4C)
Type: protein-coding
Summary: Is active in cytosol. Is expressed in several structures, including pancreas. Orthologous to human C2CD4C (C2 calcium dependent domain containing 4C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q5HZI2
Entrez ID: 237397
|
Does Knockout of Inpp5b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Inpp5b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Inpp5b (inositol polyphosphate-5-phosphatase B)
Type: protein-coding
Summary: This gene encodes a member of the inositol polyphosphate-5-phosphatase (INPP5) family. This protein hydrolyzes the 5' phosphate from phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol-1,4,5-trisphosphate, which results in changes to multiple signaling pathways. This protein may be involved in protein trafficking and secretion. Homozygous knockout mice exhibit impaired spermatogenesis and male sterility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: flagellated sperm motility, in utero embryonic development, lipid metabolic process, phosphatidylinositol dephosphorylation, regulation of protein processing, signal transduction, spermatogenesis; MF: hydrolase activity, inositol phosphate phosphatase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity, inositol-polyphosphate 5-phosphatase activity, metal ion binding, phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; CC: cytoplasm, cytoplasmic vesicle, cytosol, early endosome membrane, endoplasmic reticulum-Golgi intermediate compartment, endosome, membrane, neuron projection, phagocytic vesicle membrane
Pathways: D-<i>myo</i>-inositol (1,4,5)-trisphosphate degradation, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Synthesis of IP2, IP, and Ins in the cytosol, Synthesis of IP3 and IP4 in the cytosol, superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism
UniProt: Q8K337
Entrez ID: 16330
|
Does Knockout of Gemin4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Gemin4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gemin4 (gem nuclear organelle associated protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, spliceosomal snRNP assembly; MF: ribonucleoprotein complex binding; CC: Cajal body, SMN complex, SMN-Sm protein complex, cytosol, nuclear body, nucleolus
Pathways: Metabolism of RNA, Metabolism of non-coding RNA, snRNP Assembly
UniProt: Q6P6L6
Entrez ID: 276919
|
Does Knockout of Raver2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Raver2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Raver2 (ribonucleoprotein, PTB-binding 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q7TPD6
Entrez ID: 242570
|
Does Knockout of Gm4847 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Gm4847
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Gm4847 (predicted gene 4847)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: N,N-dimethylaniline monooxygenase activity, NADP binding, flavin adenine dinucleotide binding, hypotaurine monooxygenase activity, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen, trimethylamine monooxygenase activity; CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Drug metabolism - cytochrome P450 - Mus musculus (mouse)
UniProt: G3X946
Entrez ID: 226604
|
Does Knockout of F3 in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 617
|
Knockout
|
F3
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: F3 (coagulation factor III, tissue factor)
Type: protein-coding
Summary: This gene encodes a membrane-bound glycoprotein that forms the primary physiological initiator of the blood coagulation process following vascular damage. The encoded protein binds to coagulation factor VIIa and the ensuing complex catalyzes the proteolytic activation of coagulation factors IX and X. Mice lacking encoded protein die in utero resulting from massive hemorrhaging in both extraembryonic and embryonic vessels. A severe deficiency of the encoded protein in mice results in impaired uterine homeostasis, shorter life spans due to spontaneous fatal hemorrhages and cardiac fibrosis. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: activation of blood coagulation via clotting cascade, activation of plasma proteins involved in acute inflammatory response, blood coagulation, cytokine-mediated signaling pathway, hemostasis, positive regulation of TOR signaling, positive regulation of angiogenesis, positive regulation of endothelial cell apoptotic process, positive regulation of endothelial cell proliferation, positive regulation of gene expression, positive regulation of interleukin-8 production, positive regulation of platelet-derived growth factor receptor signaling pathway, positive regulation of positive chemotaxis, positive regulation of smooth muscle cell migration, protein processing, response to stress; MF: cytokine receptor activity, phospholipid binding, protease binding, serine-type endopeptidase activity; CC: cell surface, external side of plasma membrane, extracellular matrix, extracellular space, membrane, plasma membrane, serine-type peptidase complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Complement and coagulation cascades - Mus musculus (mouse), Extrinsic Pathway of Fibrin Clot Formation, Formation of Fibrin Clot (Clotting Cascade), Hemostasis
UniProt: P20352
Entrez ID: 14066
|
Does Knockout of Eif4a1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Eif4a1
|
cell cycle progression
|
breast epithelium
|
Gene: Eif4a1 (eukaryotic translation initiation factor 4A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, positive regulation of transcription by RNA polymerase II, translation, translational initiation; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, membrane, nuclear stress granule, perinuclear region of cytoplasm, plasma membrane
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, Cytokine Signaling in Immune system, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Eukaryotic Translation Initiation, GTP hydrolysis and joining of the 60S ribosomal subunit, ISG15 antiviral mechanism, Immune System, Interferon Signaling, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of RNA, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: P60843
Entrez ID: 13681
|
Does Knockout of Dll1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Dll1
|
phagocytosis
|
macrophage
|
Gene: Dll1 (delta like canonical Notch ligand 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, Notch signaling pathway involved in arterial endothelial cell fate commitment, animal organ morphogenesis, astrocyte development, auditory receptor cell fate commitment, cell communication, cell differentiation, cell fate commitment, cell-cell signaling, cerebellar Purkinje cell layer structural organization, cerebellar molecular layer formation, clathrin-dependent endocytosis, compartment pattern specification, determination of left/right symmetry, embryo development ending in birth or egg hatching, embryonic morphogenesis, endothelial tip cell fate specification, endothelium development, energy homeostasis, epithelial cell development, epithelial tube morphogenesis, eye morphogenesis, heart looping, in utero embryonic development, inhibition of neuroepithelial cell differentiation, inner ear auditory receptor cell differentiation, inner ear development, inner ear morphogenesis, lateral inhibition, left/right axis specification, loop of Henle development, marginal zone B cell differentiation, multicellular organismal-level homeostasis, negative regulation of Notch signaling pathway, negative regulation of cardiac muscle cell differentiation, negative regulation of cell differentiation, negative regulation of cell population proliferation, negative regulation of developmental process, negative regulation of epidermal cell differentiation, negative regulation of epithelial cell differentiation, negative regulation of glial cell apoptotic process, negative regulation of hemocyte differentiation, negative regulation of inner ear auditory receptor cell differentiation, negative regulation of interleukin-10 production, negative regulation of multicellular organismal process, negative regulation of myeloid cell differentiation, negative regulation of myoblast differentiation, negative regulation of neuron differentiation, nephron development, nervous system development, neuron differentiation, neuron fate specification, neuronal stem cell population maintenance, odontogenesis of dentin-containing tooth, organ growth, positive regulation of Notch signaling pathway, positive regulation of cell population proliferation, positive regulation of endocytosis, positive regulation of gene expression, positive regulation of skeletal muscle tissue growth, positive regulation of sprouting angiogenesis, positive regulation of transcription by RNA polymerase II, proximal tubule development, proximal/distal pattern formation, regionalization, regulation of biological quality, regulation of blood pressure, regulation of cell adhesion, regulation of cell division, regulation of developmental growth, regulation of growth, regulation of macromolecule metabolic process, regulation of neurogenesis, regulation of primary metabolic process, regulation of skeletal muscle tissue growth, regulation of somitogenesis, regulation of transport, regulation of vascular endothelial growth factor receptor signaling pathway, regulation of vascular endothelial growth factor signaling pathway, renal tubule development, retina development in camera-type eye, retina morphogenesis in camera-type eye, skeletal muscle tissue growth, skin epidermis development, somite specification, somitogenesis, spinal cord development, type B pancreatic cell development, vasculature development; MF: Notch binding, Tat protein binding, calcium ion binding, protein binding, receptor ligand activity, scaffold protein binding; CC: adherens junction, anchoring junction, apical plasma membrane, cell-cell junction, cytoplasmic vesicle, membrane, membrane raft, nucleus, plasma membrane
Pathways: Breast cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, Notch signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signal Transduction, Signaling by NOTCH, Signaling by NOTCH2, Signaling by NOTCH3, Th1 and Th2 cell differentiation - Mus musculus (mouse)
UniProt: Q61483
Entrez ID: 13388
|
Does Knockout of Gpn1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Gpn1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gpn1 (GPN-loop GTPase 1)
Type: protein-coding
Summary: Predicted to enable GTPase activity. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Is expressed in embryo; sublingual gland primordium; and submandibular gland primordium. Orthologous to human GPN1 (GPN-loop GTPase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q8VCE2
Entrez ID: 74254
|
Does Knockout of Hspe1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Hspe1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Hspe1 (heat shock protein 1 (chaperonin 10))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein folding; MF: ATP binding, metal ion binding, protein folding chaperone, protein-folding chaperone binding, unfolded protein binding; CC: mitochondrial matrix, mitochondrion
Pathways: RHO GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q64433
Entrez ID: 15528
|
Does Knockout of Ube2m in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 685
|
Knockout
|
Ube2m
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Ube2m (ubiquitin-conjugating enzyme E2M)
Type: protein-coding
Summary: Predicted to enable NEDD8 transferase activity and ubiquitin-protein transferase activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse; postsynapse; and presynapse. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human UBE2M (ubiquitin conjugating enzyme E2 M). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: positive regulation of neuron apoptotic process, protein modification process, protein neddylation, regulation of postsynapse assembly; MF: ATP binding, NEDD8 conjugating enzyme activity, NEDD8 transferase activity, nucleotide binding, transferase activity, ubiquitin-protein transferase activity; CC: cytosol, glutamatergic synapse, nucleus, postsynapse, presynapse
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Immune System, Innate Immune System, Metabolism of proteins, NIK-->noncanonical NF-kB signaling, Neddylation, Post-translational protein modification, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, TNFR2 non-canonical NF-kB pathway, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P61082
Entrez ID: 22192
|
Does Knockout of Wdr18 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Wdr18
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Wdr18 (WD repeat domain 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated DNA replication, rRNA processing; CC: cytoplasm, dynein axonemal particle, nuclear pre-replicative complex, nucleolus, nucleoplasm, nucleus, rixosome complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q4VBE8
Entrez ID: 216156
|
Does Knockout of Tbcd in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Tbcd
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tbcd (tubulin-specific chaperone d)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adherens junction assembly, bicellular tight junction assembly, cell morphogenesis involved in neuron differentiation, microtubule cytoskeleton organization, mitotic cell cycle, negative regulation of cell-substrate adhesion, negative regulation of microtubule polymerization, post-chaperonin tubulin folding pathway, protein folding, tubulin complex assembly; MF: GTPase activator activity, beta-tubulin binding; CC: adherens junction, anchoring junction, bicellular tight junction, centrosome, cytoplasm, cytoskeleton, lateral plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q8BYA0
Entrez ID: 108903
|
Does Knockout of Mcm9 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Mcm9
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Mcm9 (minichromosome maintenance 9 homologous recombination repair factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, double-strand break repair via homologous recombination, female gamete generation, gamete generation, mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication, protein localization to chromatin, recombinational interstrand cross-link repair; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, MutLbeta complex binding, MutSalpha complex binding, MutSbeta complex binding, chromatin binding, enzyme binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, protein-containing complex binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: MCM complex, MCM8-MCM9 complex, chromosome, nucleus
Pathways:
UniProt: Q2KHI9
Entrez ID: 71567
|
Does Knockout of Ddx5 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Ddx5
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Ddx5 (DEAD box helicase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, RNA splicing, alternative mRNA splicing, via spliceosome, androgen receptor signaling pathway, circadian rhythm, epithelial to mesenchymal transition, estrogen receptor signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, mRNA processing, mRNA transcription, miRNA transcription, myoblast differentiation, negative regulation of transcription by RNA polymerase II, nuclear-transcribed mRNA catabolic process, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of DNA-templated transcription, primary miRNA processing, protein import into nucleus, regulation of alternative mRNA splicing, via spliceosome, regulation of androgen receptor signaling pathway, regulation of osteoblast differentiation, regulation of skeletal muscle cell differentiation, regulation of transcription by RNA polymerase II, regulation of viral genome replication, rhythmic process; MF: ATP binding, ATP hydrolysis activity, MH2 domain binding, R-SMAD binding, RNA binding, RNA helicase activity, SMAD binding, calcium-dependent protein binding, calmodulin binding, enzyme binding, helicase activity, hydrolase activity, mRNA 3'-UTR binding, mRNA binding, nuclear androgen receptor binding, nucleic acid binding, nucleotide binding, pre-mRNA binding, primary miRNA binding, promoter-specific chromatin binding, protein binding, ribonucleoprotein complex binding, transcription coregulator activity; CC: catalytic step 2 spliceosome, cytoplasm, nuclear speck, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Proteoglycans in cancer - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: S4R1I6, Q8BTS0, B1ARB9, B1ARC0, S4R1E3
Entrez ID: 13207
|
Does Knockout of Nacc2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Nacc2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nacc2 (nucleus accumbens associated 2, BEN and BTB (POZ) domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage, protein homooligomerization, protein-containing complex localization, regulation of cell population proliferation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone deacetylase binding, protein homodimerization activity, protein-containing complex binding; CC: chromatin, mitochondrion, nuclear lumen, nucleolus, nucleus
Pathways:
UniProt: Q9DCM7
Entrez ID: 67991
|
Does Knockout of Mylk4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Mylk4
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mylk4 (myosin light chain kinase family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: sarcomere organization, signal transduction; MF: ATP binding, calcium/calmodulin-dependent protein kinase activity, kinase activity, myosin light chain kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways: Apelin signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt:
Entrez ID: 238564
|
Does Knockout of Zfp37 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Zfp37
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Zfp37 (zinc finger protein 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, germ cell development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: P17141
Entrez ID: 22696
|
Does Knockout of Tcfl5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Tcfl5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tcfl5 (transcription factor-like 5 (basic helix-loop-helix))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell differentiation, regulation of cell population proliferation, spermatogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: male germ cell nucleus, nucleus
Pathways:
UniProt: E9Q5K1, Q32NY8
Entrez ID: 277353
|
Does Knockout of Akr1b8 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Akr1b8
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Akr1b8 (aldo-keto reductase family 1, member B8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, polyol metabolic process, retinal metabolic process, retinol metabolic process; MF: NADP+ binding, NADPH binding, alcohol dehydrogenase (NADP+) activity, aldose reductase (NADPH) activity, all-trans-retinol dehydrogenase (NADP+) activity, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, geranylgeranyl reductase activity, indanol dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, retinal binding, retinal dehydrogenase (NAD+) activity; CC: cytoplasm, cytosol, extracellular region, lysosome, mitochondrion
Pathways: Estrogen biosynthesis, Folate biosynthesis - Mus musculus (mouse), Fructose and mannose metabolism - Mus musculus (mouse), Galactose metabolism - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), L-arabinose degradation II, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Pentose and glucuronate interconversions - Mus musculus (mouse)
UniProt: P45377
Entrez ID: 14187
|
Does Knockout of Eif2s3y in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Eif2s3y
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Eif2s3y (eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of translation preinitiation complex, positive regulation of male gonad development, spermatogenesis, translation, translational initiation; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, tRNA binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, eukaryotic translation initiation factor 2 complex
Pathways:
UniProt: Q9Z0N2
Entrez ID: 26908
|
Does Knockout of BC005537 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
BC005537
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: BC005537 (cDNA sequence BC005537)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q99LU8
Entrez ID: 79555
|
Does Knockout of Phrf1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Phrf1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Phrf1 (PHD and ring finger domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA processing, transcription by RNA polymerase II; MF: RNA polymerase binding, metal ion binding, protein domain specific binding, zinc ion binding
Pathways:
UniProt: A6H619
Entrez ID: 101471
|
Does Knockout of Ankrd37 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Ankrd37
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ankrd37 (ankyrin repeat domain 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, male germ cell nucleus, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q569N2
Entrez ID: 654824
|
Does Knockout of Ggps1 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 1
| 1,521
|
Knockout
|
Ggps1
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Ggps1 (geranylgeranyl diphosphate synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: farnesyl diphosphate biosynthetic process, geranyl diphosphate biosynthetic process, geranylgeranyl diphosphate biosynthetic process, isoprenoid biosynthetic process, isoprenoid metabolic process, lipid metabolic process; MF: (2E,6E)-farnesyl diphosphate synthase activity, dimethylallyltranstransferase activity, geranylgeranyl diphosphate synthase activity, identical protein binding, metal ion binding, prenyl diphosphate synthase activity, prenyltransferase activity, transferase activity; CC: Z disc, cytoplasm, cytosol, nucleoplasm, perinuclear region of cytoplasm
Pathways: <i>trans, trans</i>-farnesyl diphosphate biosynthesis, Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, Terpenoid backbone biosynthesis - Mus musculus (mouse), superpathway of cholesterol biosynthesis
UniProt: Q9WTN0
Entrez ID: 14593
|
Does Knockout of Foxo3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Foxo3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Foxo3 (forkhead box O3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, antral ovarian follicle growth, apoptotic process, brain morphogenesis, cellular response to amyloid-beta, cellular response to corticosterone stimulus, cellular response to glucose starvation, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to nerve growth factor stimulus, cellular response to oxidative stress, extrinsic apoptotic signaling pathway in absence of ligand, glucose homeostasis, initiation of primordial ovarian follicle growth, mitochondrial transcription, negative regulation of canonical Wnt signaling pathway, negative regulation of cell migration, negative regulation of neuron differentiation, negative regulation of transcription by RNA polymerase II, neuronal stem cell population maintenance, oocyte maturation, ovulation from ovarian follicle, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of autophagy, positive regulation of endothelial cell apoptotic process, positive regulation of erythrocyte differentiation, positive regulation of hydrogen peroxide-mediated programmed cell death, positive regulation of miRNA transcription, positive regulation of muscle atrophy, positive regulation of neuron apoptotic process, positive regulation of reactive oxygen species biosynthetic process, positive regulation of regulatory T cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neural precursor cell proliferation, regulation of reactive oxygen species metabolic process, regulation of transcription by RNA polymerase II, regulation of translation, response to dexamethasone, response to fatty acid, response to nutrient levels, response to starvation, response to water-immersion restraint stress, response to xenobiotic stimulus, tumor necrosis factor-mediated signaling pathway; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, beta-catenin binding, chromatin DNA binding, mitochondrial transcription factor activity, protein binding, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding; CC: RNA polymerase II transcription repressor complex, cytoplasm, cytosol, membrane, mitochondrial matrix, mitochondrial outer membrane, mitochondrion, nucleoplasm, nucleus, protein-containing complex
Pathways: AKT phosphorylates targets in the nucleus, AMPK signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cytokine Signaling in Immune system, Developmental Biology, ESR-mediated signaling, Endometrial cancer - Mus musculus (mouse), Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Extra-nuclear estrogen signaling, FLT3 Signaling, FOXO-mediated transcription, FOXO-mediated transcription of cell cycle genes, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Immune System, Intracellular signaling by second messengers, Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK family signaling cascades, MAPK6/MAPK4 signaling, Mitochondrial unfolded protein response (UPRmt), Mitophagy - animal - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PIP3 activates AKT signaling, Prolactin signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of FOXO transcriptional activity by acetylation, Regulation of localization of FOXO transcription factors, Signal Transduction, Signaling by NODAL, Signaling by Nuclear Receptors
UniProt: Q9WVH4
Entrez ID: 56484
|
Does Knockout of Gucy1b2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Gucy1b2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gucy1b2 (guanylate cyclase 1, soluble, beta 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cGMP biosynthetic process, cGMP-mediated signaling, cyclic nucleotide biosynthetic process, intracellular signal transduction, response to oxygen levels; MF: GTP binding, guanylate cyclase activity, heme binding, lyase activity, nitric oxide binding, nucleotide binding, phosphorus-oxygen lyase activity; CC: cytoplasm, cytosol, guanylate cyclase complex, soluble
Pathways: Circadian entrainment - Mus musculus (mouse), Gap junction - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Muscle contraction, Oxytocin signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Smooth Muscle Contraction, Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), cyclic GMP biosynthesis
UniProt: E9Q6H0, Q8BXH3
Entrez ID: 239134
|
Does Knockout of Wfs1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Wfs1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Wfs1 (wolframin ER transmembrane glycoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ER overload response, ERAD pathway, calcium ion homeostasis, endoplasmic reticulum calcium ion homeostasis, endoplasmic reticulum unfolded protein response, glucose homeostasis, intracellular signal transduction, kidney development, negative regulation of ATF6-mediated unfolded protein response, negative regulation of apoptotic process, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of intracellular signal transduction, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of macromolecule biosynthetic process, negative regulation of neuron apoptotic process, negative regulation of programmed cell death, negative regulation of response to endoplasmic reticulum stress, negative regulation of transcription by RNA polymerase II, negative regulation of translation, negative regulation of type B pancreatic cell apoptotic process, nervous system process, olfactory behavior, pancreas development, positive regulation of ERAD pathway, positive regulation of calcium ion transport, positive regulation of growth, positive regulation of protein metabolic process, positive regulation of protein ubiquitination, protein stabilization, regulation of cell cycle, regulation of gene expression, renal water homeostasis, response to endoplasmic reticulum stress, sensory perception of sound, visual perception; MF: ATPase binding, DNA-binding transcription factor binding, calcium-dependent protein binding, calmodulin binding, proteasome binding, protein carrier chaperone, ubiquitin protein ligase binding; CC: cytoplasmic vesicle, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, secretory granule, synaptic vesicle membrane, transport vesicle
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: P56695
Entrez ID: 22393
|
Does Knockout of Kdm5c in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Kdm5c
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Kdm5c (lysine demethylase 5C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of circadian rhythm, rhythmic process; MF: DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, dioxygenase activity, histone H3K4 demethylase activity, histone H3K4me/H3K4me2/H3K4me3 demethylase activity, identical protein binding, metal ion binding, oxidoreductase activity, zinc ion binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones
UniProt: P41230
Entrez ID: 20591
|
Does Knockout of Diaph1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 167
|
Knockout
|
Diaph1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Diaph1 (diaphanous related formin 1)
Type: protein-coding
Summary: This gene encodes a member of the formin family of proteins that play important roles in cytoskeletal rearragnement by nucleation of actin filaments. Mice lacking the encoded protein develop age-dependent myeloproliferative defects resembling human myeloproliferative syndrome and myelodysplastic syndromes. Trafficking of T lymphocytes to secondary lymphoid organs and egression of thymocytes from the thymus are impaired in these animals. Lack of the encoded protein in T lymphocytes and thymocytes also reduces chemotaxis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: actin cytoskeleton organization, actin filament polymerization, actin nucleation, axon midline choice point recognition, brain development, cellular response to histamine, cytoskeleton organization, ephrin receptor signaling pathway, gene expression, intracellular protein localization, multicellular organismal locomotion, negative regulation of cellular component organization, negative regulation of neuron projection regeneration, neuron projection development, neuron projection retraction, positive regulation of cell migration, protein localization to microtubule, regulation of cell shape, regulation of cytoskeleton organization, regulation of microtubule-based process, regulation of release of sequestered calcium ion into cytosol, sensory perception of sound, synaptic vesicle endocytosis; MF: actin binding, identical protein binding, profilin binding, protein binding, small GTPase binding, transmembrane transporter binding; CC: actin filament, brush border, cell projection, centrosome, cytoplasm, cytoskeleton, membrane, mitotic spindle, neuron projection, nucleus, plasma membrane, presynapse, ruffle membrane, spindle
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), ERBB2 Regulates Cell Motility, Focal adhesion - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by ERBB2, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O08808
Entrez ID: 13367
|
Does Knockout of Ttk in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Ttk
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ttk (Ttk protein kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, female meiosis chromosome segregation, meiotic spindle assembly checkpoint signaling, mitotic spindle assembly checkpoint signaling, nuclear chromosome segregation, nuclear division, protein localization to chromosome, protein localization to kinetochore, protein localization to meiotic spindle midzone, repair of mitotic kinetochore microtubule attachment defect; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, kinetochore, membrane, nucleus
Pathways: Cell cycle - Mus musculus (mouse)
UniProt: P35761
Entrez ID: 22137
|
Does Knockout of Pigs in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Pigs
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Pigs (phosphatidylinositol glycan anchor biosynthesis, class S)
Type: protein-coding
Summary: Involved in attachment of GPI anchor to protein. Part of GPI-anchor transamidase complex. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 95. Orthologous to human PIGS (phosphatidylinositol glycan anchor biosynthesis class S). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: GPI anchor biosynthetic process, GPI anchored protein biosynthesis, attachment of GPI anchor to protein; CC: GPI-anchor transamidase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Attachment of GPI anchor to uPAR, Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q6PD26
Entrez ID: 276846
|
Does Knockout of Hibch in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Hibch
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hibch (3-hydroxyisobutyryl-Coenzyme A hydrolase)
Type: protein-coding
Summary: Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in 3-hydroxyisobutryl-CoA hydrolase deficiency. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: L-valine catabolic process, branched-chain amino acid catabolic process; MF: 3-hydroxyisobutyryl-CoA hydrolase activity, hydrolase activity; CC: mitochondrion
Pathways: Branched-chain amino acid catabolism, Metabolism, Metabolism of amino acids and derivatives, Propanoate metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse), valine degradation, valine degradation I
UniProt: Q8QZS1
Entrez ID: 227095
|
Does Knockout of Mgme1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,555
|
Knockout
|
Mgme1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Mgme1 (mitochondrial genome maintenance exonuclease 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, mitochondrial DNA repair, mitochondrial DNA replication; MF: 5'-flap endonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, single-stranded DNA 5'-3' DNA exonuclease activity, single-stranded DNA exodeoxyribonuclease activity; CC: mitochondrion
Pathways:
UniProt: Q9CXC3
Entrez ID: 74528
|
Does Knockout of Crisp3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Crisp3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Crisp3 (cysteine-rich secretory protein 3)
Type: protein-coding
Summary: Predicted to be involved in sexual reproduction. Predicted to be located in extracellular region and transport vesicle. Predicted to be active in extracellular space. Is expressed in sublingual gland and submandibular gland. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: CC: cytoplasmic vesicle, extracellular region, extracellular space, transport vesicle
Pathways:
UniProt: Q03402
Entrez ID: 11572
|
Does Knockout of Cyp2f2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Cyp2f2
|
cell proliferation
|
Regulatory T cell
|
Gene: Cyp2f2 (cytochrome P450, family 2, subfamily f, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxygenase P450 pathway, naphthalene catabolic process, response to toxic substance, trichloroethylene metabolic process, xenobiotic metabolic process; MF: arachidonate epoxygenase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, oxygen binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Biological oxidations, CYP2E1 reactions, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Cytochrome P450 - arranged by substrate type, Fatty acids, Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Phase I - Functionalization of compounds, Xenobiotics
UniProt: P33267
Entrez ID: 13107
|
Does Knockout of Fam168a in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Fam168a
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Fam168a (family with sequence similarity 168, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of base-excision repair
Pathways:
UniProt: Q8BGZ2
Entrez ID: 319604
|
Does Knockout of Ccdc54 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Ccdc54
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ccdc54 (coiled-coil domain containing 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DAL3
Entrez ID: 69339
|
Does Knockout of Alox12b in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Alox12b
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Alox12b (arachidonate 12-lipoxygenase, 12R type)
Type: protein-coding
Summary: This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene can prevent the formation of the epidermal permeability barrier and cause an ichthyosiform phenotype. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: arachidonate metabolic process, bicellular tight junction assembly, ceramide biosynthetic process, establishment of skin barrier, fatty acid metabolic process, hepoxilin biosynthetic process, linoleic acid metabolic process, lipid metabolic process, lipid oxidation, lipoxygenase pathway, positive regulation of MAPK cascade, positive regulation of gene expression, positive regulation of mucus secretion, protein lipidation, sphingolipid metabolic process; MF: arachidonate 12(R)-lipoxygenase activity, arachidonate 12(S)-lipoxygenase activity, arachidonate 8(R)-lipoxygenase activity, dioxygenase activity, iron ion binding, linoleate 9S-lipoxygenase activity, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; CC: cytoplasm, cytosol, membrane, perinuclear region of cytoplasm
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Serotonergic synapse - Mus musculus (mouse), Synthesis of 12-eicosatetraenoic acid derivatives
UniProt: O70582
Entrez ID: 11686
|
Does Knockout of Bpi in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Bpi
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Bpi (bactericidal permeablility increasing protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, cellular response to lipopolysaccharide, defense response to Gram-negative bacterium, defense response to bacterium, immune response, immune system process, innate immune response, lipopolysaccharide-mediated signaling pathway, negative regulation of interleukin-6 production, negative regulation of interleukin-8 production, negative regulation of macrophage activation, negative regulation of tumor necrosis factor production; MF: lipid binding, lipopolysaccharide binding; CC: cytoplasm, cytoplasmic stress granule, extracellular region, extracellular space, membrane
Pathways: Antimicrobial peptides, Immune System, Innate Immune System, Neutrophil degranulation, Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades
UniProt: Q67E05
Entrez ID: 329547
|
Does Knockout of Tcp1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Tcp1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Tcp1 (t-complex protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of establishment of protein localization to telomere, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, scaRNA localization to Cajal body; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, ubiquitin protein ligase binding, unfolded protein binding; CC: Golgi apparatus, acrosomal vesicle, cell body, centrosome, chaperonin-containing T-complex, cytoplasm, cytoskeleton, cytosol, heterochromatin, microtubule, microtubule organizing center, myelin sheath, pericentriolar material, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: P11983
Entrez ID: 21454
|
Does Knockout of Tmprss11g in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Tmprss11g
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tmprss11g (transmembrane protease, serine 11g)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Orthologous to human TMPRSS11GP (transmembrane serine protease 11G, pseudogene). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: Q8BZ10
Entrez ID: 320454
|
Does Knockout of Pira1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Pira1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pira1 (paired-Ig-like receptor A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: B cell receptor signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse)
UniProt:
Entrez ID: 18722
|
Does Knockout of Rhox6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Rhox6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rhox6 (reproductive homeobox 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific; CC: cellular_component, nucleus
Pathways:
UniProt: O70238
Entrez ID: 19202
|
Does Knockout of Dhrs7c in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Dhrs7c
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Dhrs7c (dehydrogenase/reductase 7C)
Type: protein-coding
Summary: Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in D-glucose import; intracellular calcium ion homeostasis; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Located in longitudinal sarcoplasmic reticulum and sarcoplasmic reticulum membrane. Orthologous to human DHRS7C (dehydrogenase/reductase 7C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: D-glucose import, intracellular calcium ion homeostasis, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; MF: all-trans-retinol dehydrogenase (NAD+) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: cytoplasm, longitudinal sarcoplasmic reticulum, membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways:
UniProt: Q8CHS7
Entrez ID: 68460
|
Does Knockout of Ppp2r1b in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Ppp2r1b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ppp2r1b (protein phosphatase 2, regulatory subunit A, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process involved in morphogenesis, meiotic sister chromatid cohesion, centromeric, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, spindle assembly; MF: protein binding, protein phosphatase regulator activity; CC: cytoplasm, cytosol, glutamatergic synapse, membrane raft, nucleus, protein phosphatase type 2A complex, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Antiviral mechanism by IFN-stimulated genes, Beta-catenin phosphorylation cascade, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chagas disease - Mus musculus (mouse), Co-inhibition by CTLA4, Co-stimulation by CD28, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin D associated events in G1, Cytokine Signaling in Immune system, DARPP-32 events, Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Dopaminergic synapse - Mus musculus (mouse), E2F mediated regulation of DNA replication, EML4 and NUDC in mitotic spindle formation, ERK/MAPK targets, ERKs are inactivated, G alpha (i) signalling events, G1 Phase, G1/S Transition, G2/M Transition, GPCR downstream signalling, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, Hepatitis C - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Innate Immune System, Interferon Signaling, Interleukin-17 signaling, Intracellular signaling by second messengers, Long-term depression - Mus musculus (mouse), M Phase, MAP kinase activation, MAPK family signaling cascades, MAPK targets/ Nuclear events mediated by MAP kinases, MAPK1/MAPK3 signaling, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Negative regulation of MAPK pathway, Negative regulation of the PI3K/AKT network, Nuclear Events (kinase and transcription factor activation), Oocyte meiosis - Mus musculus (mouse), Opioid Signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PKR-mediated signaling, Platelet homeostasis, Platelet sensitization by LDL, RAF activation, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Resolution of Sister Chromatid Cohesion, Response of endothelial cells to shear stress, Separation of Sister Chromatids, Signal Transduction, Signaling by GPCR, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Sphingolipid signaling pathway - Mus musculus (mouse), TCF dependent signaling in response to WNT, TGF-beta signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Tight junction - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcriptional Regulation by TP53, Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q7TNP2
Entrez ID: 73699
|
Does Knockout of Plekhm3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Plekhm3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Plekhm3 (pleckstrin homology domain containing, family M, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, protein binding, zinc ion binding; CC: Golgi apparatus, cytoplasm, membrane, plasma membrane
Pathways:
UniProt: Q8BM47
Entrez ID: 241075
|
Does Knockout of Msr1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Msr1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Msr1 (macrophage scavenger receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid-beta clearance, cholesterol transport, endocytosis, establishment of localization in cell, lipoprotein transport, negative regulation of gene expression, phagocytosis, engulfment, plasma lipoprotein particle clearance, positive regulation of cholesterol storage, positive regulation of macrophage derived foam cell differentiation, receptor-mediated endocytosis; MF: amyloid-beta binding, cargo receptor activity, low-density lipoprotein particle binding, scavenger receptor activity; CC: collagen trimer, low-density lipoprotein particle, membrane, plasma membrane
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Phagosome - Mus musculus (mouse), Scavenging by Class A Receptors, Vesicle-mediated transport
UniProt: P30204
Entrez ID: 20288
|
Does Knockout of Cox7a2l in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Cox7a2l
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cox7a2l (cytochrome c oxidase subunit 7A2 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, mitochondrial respirasome assembly; MF: protein-macromolecule adaptor activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleolus, respiratory chain complex, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: Q61387
Entrez ID: 20463
|
Does Knockout of Galnt3 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Galnt3
|
phagocytosis
|
macrophage
|
Gene: Galnt3 (polypeptide N-acetylgalactosaminyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cell maturation, chondrocyte development, chondroitin sulfate proteoglycan biosynthetic process, endochondral ossification, gene expression, limb development, multicellular organism growth, polysaccharide metabolic process, protein O-linked glycosylation, protein glycosylation, spermatogenesis; MF: calcium ion binding, carbohydrate binding, glycosyltransferase activity, manganese ion binding, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane, perinuclear region of cytoplasm
Pathways: FGFR3 ligand binding and activation, FGFR3c ligand binding and activation, Metabolism of proteins, Mucin type O-glycan biosynthesis - Mus musculus (mouse), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Signal Transduction, Signaling by FGFR, Signaling by FGFR3, Signaling by Receptor Tyrosine Kinases
UniProt: P70419
Entrez ID: 14425
|
Does Knockout of Rttn in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Rttn
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rttn (rotatin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, centriole-centriole cohesion, ciliary basal body organization, cilium organization, determination of left/right symmetry; CC: cell projection, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, membrane
Pathways:
UniProt: Q8R4Y8
Entrez ID: 246102
|
Does Knockout of Dmrtc1b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Dmrtc1b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Dmrtc1b (DMRT-like family C1b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q2PMX7, A2AI93, Q2PMX6
Entrez ID: 632708
|
Does Knockout of Fbxo33 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Fbxo33
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fbxo33 (F-box protein 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein ubiquitination, protein ubiquitination
Pathways:
UniProt: Q8VE08
Entrez ID: 70611
|
Does Knockout of Bnc1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Bnc1
|
cell cycle progression
|
breast epithelium
|
Gene: Bnc1 (basonuclin zinc finger protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chromosome organization, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of oocyte maturation, positive regulation of transcription by RNA polymerase I, regulation of transcription by RNA polymerase I, regulation of transcription by RNA polymerase II, spermatogenesis, wound healing; MF: DNA binding, DNA-binding transcription activator activity, metal ion binding, protein binding, rDNA binding, zinc ion binding; CC: cytoplasm, nuclear lumen, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: F8VPY0
Entrez ID: 12173
|
Does Knockout of Irf5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Irf5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Irf5 (interferon regulatory factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to muramyl dipeptide, cellular response to peptidoglycan, cellular response to virus, cytokine-mediated signaling pathway, defense response to virus, immune system process, inflammatory response, innate immune response, nucleotide-binding oligomerization domain containing 2 signaling pathway, positive regulation of apoptotic process, positive regulation of cytokine production involved in immune response, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of interleukin-12 production, positive regulation of transcription by RNA polymerase II, positive regulation of type I interferon production, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, protein kinase binding, protein serine/threonine kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: cytoplasm, nucleus
Pathways: Immune System, Innate Immune System, SLC15A4:TASL-dependent IRF5 activation, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse)
UniProt: P56477
Entrez ID: 27056
|
Does Knockout of Fras1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Fras1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Fras1 (Fraser extracellular matrix complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, animal organ development, cell communication, embryonic limb morphogenesis, metanephros morphogenesis, morphogenesis of an epithelium, protein transport, roof of mouth development, skin development, system development; MF: extracellular matrix structural constituent, metal ion binding, protein binding; CC: basement membrane, cell periphery, extracellular matrix, membrane, plasma membrane
Pathways: ECM-receptor interaction - Mus musculus (mouse)
UniProt: Q80T14
Entrez ID: 231470
|
Does Knockout of Herc4 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Herc4
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Herc4 (hect domain and RLD 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of smoothened signaling pathway, protein ubiquitination, spermatogenesis, ubiquitin-dependent protein catabolic process; MF: transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytoplasm, cytosol, fibrillar center
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q6PAV2
Entrez ID: 67345
|
Does Knockout of Taf10 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,308
|
Knockout
|
Taf10
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Taf10 (TATA-box binding protein associated factor 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, G1/S transition of mitotic cell cycle, RNA polymerase II preinitiation complex assembly, SAGA complex assembly, allantois development, apoptotic process, chromatin remodeling, embryonic placenta development, gene expression, hepatocyte differentiation, in utero embryonic development, lateral mesodermal cell differentiation, limb development, liver development, mRNA transcription by RNA polymerase II, multicellular organism growth, positive regulation of DNA-templated transcription, positive regulation of transcription initiation by RNA polymerase II, protein-containing complex assembly, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of gene expression, regulation of transcription by RNA polymerase II, somitogenesis, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase binding, enzyme binding, histone acetyltransferase activity, identical protein binding, nuclear estrogen receptor binding, promoter-specific chromatin binding, protein binding; CC: SAGA complex, cytoplasm, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, transcription factor TFIID complex, transcription factor TFTC complex, transcription preinitiation complex
Pathways: Basal transcription factors - Mus musculus (mouse), Deubiquitination, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53, Ub-specific processing proteases
UniProt: Q8K0H5
Entrez ID: 24075
|
Does Knockout of Tigar in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Tigar
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tigar (Trp53 induced glycolysis regulatory phosphatase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, apoptotic process, autophagy, cellular response to cobalt ion, cellular response to hypoxia, fructose 2,6-bisphosphate metabolic process, intestinal epithelial cell development, negative regulation of glucose catabolic process to lactate via pyruvate, negative regulation of glycolytic process, negative regulation of mitophagy, negative regulation of programmed cell death, negative regulation of reactive oxygen species metabolic process, positive regulation of DNA repair, positive regulation of cardiac muscle cell apoptotic process, positive regulation of hexokinase activity, positive regulation of nucleobase-containing compound metabolic process, positive regulation of pentose-phosphate shunt, positive regulation of phosphate metabolic process, regulation of pentose-phosphate shunt, regulation of programmed cell death, regulation of response to DNA damage checkpoint signaling, response to gamma radiation, response to ischemia, response to stress, response to xenobiotic stimulus; MF: catalytic activity, fructose-2,6-bisphosphate 2-phosphatase activity, hydrolase activity; CC: cytoplasm, cytosol, mitochondrial outer membrane, mitochondrion, nucleus
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), Fructose and mannose metabolism - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53
UniProt: Q8BZA9
Entrez ID: 319801
|
Does Knockout of Mmp16 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Mmp16
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mmp16 (matrix metallopeptidase 16)
Type: protein-coding
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit retarded growth of the skeleton, especially in the cranium and long bones. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: bone development, chondrocyte proliferation, collagen catabolic process, craniofacial suture morphogenesis, embryonic cranial skeleton morphogenesis, endochondral ossification, extracellular matrix organization, ossification, protein processing, proteolysis, skeletal system development; MF: hydrolase activity, metal ion binding, metalloaminopeptidase activity, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular space, membrane, plasma membrane
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, MicroRNAs in cancer - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Signal Transduction, Signaling by TGFB family members, Signaling by TGFBR3, TGFBR3 PTM regulation
UniProt: Q9WTR0
Entrez ID: 17389
|
Does Knockout of Nkd1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Nkd1
|
cell cycle progression
|
breast epithelium
|
Gene: Nkd1 (naked cuticle 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, axis elongation, cell differentiation, convergent extension, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, positive regulation of MAPK cascade, positive regulation of Wnt signaling pathway, planar cell polarity pathway, positive regulation of non-canonical Wnt signaling pathway, positive regulation of protein catabolic process, spermatogenesis; MF: PDZ domain binding, calcium ion binding, metal ion binding, protein binding; CC: cytoplasm, membrane, plasma membrane, protein phosphatase type 2A complex
Pathways: Hippo signaling pathway - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q99MH6
Entrez ID: 93960
|
Does Knockout of Gzf1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Gzf1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gzf1 (GDNF-inducible zinc finger protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: branching involved in ureteric bud morphogenesis, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q4VBD9
Entrez ID: 74533
|
Does Knockout of Mrpl39 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Mrpl39
|
response to virus
|
Microglial Cell Line
|
Gene: Mrpl39 (mitochondrial ribosomal protein L39)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, mitochondrion organization, translation; MF: nucleotide binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9JKF7
Entrez ID: 27393
|
Does Knockout of Car5a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Car5a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Car5a (carbonic anhydrase 5a, mitochondrial)
Type: protein-coding
Summary: Enables carbonate dehydratase activity. Predicted to act upstream of or within gluconeogenesis. Located in mitochondrion. Is expressed in inner ear; liver; metanephros; and trunk. Orthologous to human CA5A (carbonic anhydrase 5A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: carbonate dehydratase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytoplasm, mitochondrion
Pathways: Metabolism, Nitrogen metabolism - Mus musculus (mouse), Reversible hydration of carbon dioxide
UniProt: P23589
Entrez ID: 12352
|
Does Knockout of Cmtm2a in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Cmtm2a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cmtm2a (CKLF-like MARVEL transmembrane domain containing 2A)
Type: protein-coding
Summary: Enables transcription corepressor activity. Acts upstream of or within negative regulation of DNA-templated transcription and regulation of testosterone biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human CMTM2 (CKLF like MARVEL transmembrane domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chemotaxis, negative regulation of DNA-templated transcription, regulation of testosterone biosynthetic process, signal transduction; MF: cytokine activity, protein binding, transcription corepressor activity; CC: cytoplasm, extracellular space, membrane, nucleus
Pathways:
UniProt: Q9DAR1
Entrez ID: 73381
|
Does Knockout of Me2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Me2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Me2 (malic enzyme 2, NAD(+)-dependent, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: malate metabolic process, pyruvate metabolic process, regulation of NADP metabolic process; MF: NAD binding, catalytic activity, malate dehydrogenase (decarboxylating) (NAD+) activity, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, metal ion binding, oxaloacetate decarboxylase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Metabolism of proteins, Mitochondrial protein degradation, Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), gluconeogenesis I
UniProt: Q99KE1
Entrez ID: 107029
|
Does Knockout of Exoc8 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Exoc8
|
cell proliferation
|
Regulatory T cell
|
Gene: Exoc8 (exocyst complex component 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, endosome organization, exocytosis, extracellular matrix disassembly, intracellular protein localization, membrane fission, mitotic cytokinesis, protein transport, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; MF: phosphatidylinositol binding, small GTPase binding; CC: cell leading edge, cell periphery, cell projection, cytoplasm, exocyst, growth cone, late endosome, perinuclear region of cytoplasm, plasma membrane
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Insulin processing, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, VxPx cargo-targeting to cilium
UniProt: Q6PGF7
Entrez ID: 102058
|
Does Knockout of Fhod1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Fhod1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fhod1 (formin homology 2 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, establishment of centrosome localization, nuclear migration, positive regulation of stress fiber assembly, positive regulation of transcription by RNA polymerase II, regulation of stress fiber assembly; MF: actin binding, actin filament binding, identical protein binding; CC: bleb, cell projection, cytoplasm, cytoskeleton, cytosol, intercalated disc, nucleoplasm, nucleus, stress fiber
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q6P9Q4
Entrez ID: 234686
|
Does Knockout of Prdm9 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Prdm9
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prdm9 (PR domain containing 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, double-strand break repair involved in meiotic recombination, female gamete generation, homologous chromosome pairing at meiosis, homologous recombination, male gamete generation, meiosis I cell cycle process, meiotic cell cycle, meiotic gene conversion, methylation, negative regulation of apoptotic process, positive regulation of fertilization, positive regulation of meiosis I, positive regulation of reciprocal meiotic recombination, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression, spermatogenesis; MF: DNA binding, histone H3K36 methyltransferase activity, histone H3K36 trimethyltransferase activity, histone H3K4 methyltransferase activity, histone H3K4 trimethyltransferase activity, histone H3K9 trimethyltransferase activity, histone H4K20 monomethyltransferase activity, histone H4K20me methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, protein binding, protein homodimerization activity, protein-lysine N-methyltransferase activity, recombination hotspot binding, sequence-specific DNA binding, transcription cis-regulatory region binding, transferase activity, zinc ion binding; CC: chromatin, chromosome, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Lysine degradation - Mus musculus (mouse), PKMTs methylate histone lysines
UniProt: Q96EQ9
Entrez ID: 213389
|
Does Knockout of Lce1f in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Lce1f
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lce1f (late cornified envelope 1F)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D1I4, B9EJP6
Entrez ID: 67828
|
Does Knockout of Supt6 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Supt6
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Supt6 (SPT6, histone chaperone and transcription elongation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, blastocyst formation, mRNA processing, mRNA transport, nucleobase-containing compound metabolic process, nucleosome organization, positive regulation of transcription elongation by RNA polymerase II, regulation of isotype switching, regulation of muscle cell differentiation, transcription elongation by RNA polymerase II, transcription elongation-coupled chromatin remodeling; MF: DNA binding, histone binding, nucleic acid binding, nucleosome binding, protein binding; CC: nucleus, transcription elongation factor complex
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q62383
Entrez ID: 20926
|
Does Knockout of Nfatc2ip in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Nfatc2ip
|
response to bacteria
|
macrophage
|
Gene: Nfatc2ip (nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II; CC: cytoplasm, nucleus
Pathways:
UniProt: O09130
Entrez ID: 18020
|
Does Knockout of 4930553M12Rik in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
4930553M12Rik
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: 4930553M12Rik (RIKEN cDNA 4930553M12 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Eno1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Eno1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Eno1 (enolase 1, alpha non-neuron)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, cellular response to interleukin-7, gluconeogenesis, glyceraldehyde-3-phosphate biosynthetic process, glycolytic process, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of cell growth, negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of ATP biosynthetic process, positive regulation of muscle contraction, positive regulation of plasminogen activation; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, GTPase binding, RNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, enzyme binding, heat shock protein binding, identical protein binding, lyase activity, magnesium ion binding, metal ion binding, phosphopyruvate hydratase activity, protein binding, protein homodimerization activity, protein-containing complex binding, transcription corepressor activity, transcription corepressor binding; CC: cell cortex, cell surface, cytoplasm, cytosol, growth cone, membrane, membrane raft, myelin sheath, nuclear outer membrane, phosphopyruvate hydratase complex, plasma membrane, synaptic membrane
Pathways: Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), RNA degradation - Mus musculus (mouse), gluconeogenesis I, glycolysis I, glycolysis III, glycolysis V (Pyrococcus)
UniProt: P17182
Entrez ID: 13806
|
Does Knockout of Omd in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Omd
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Omd (osteomodulin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular matrix, extracellular region, extracellular space
Pathways: Glycosaminoglycan metabolism, Keratan sulfate biosynthesis, Keratan sulfate degradation, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: O35103
Entrez ID: 27047
|
Does Knockout of Fgf4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Fgf4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Fgf4 (fibroblast growth factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process involved in morphogenesis, cartilage condensation, cell differentiation, cellular response to leukemia inhibitory factor, chondroblast differentiation, cranial suture morphogenesis, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, epithelial cell apoptotic process, fibroblast growth factor receptor signaling pathway, mesenchymal cell proliferation, negative regulation of apoptotic process, neurogenesis, odontogenesis of dentin-containing tooth, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of cell division, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of cell migration, regulation of endothelial cell chemotaxis to fibroblast growth factor, regulation of gene expression, somatic stem cell population maintenance, stem cell population maintenance; MF: fibroblast growth factor receptor binding, growth factor activity, protein binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, FGFR1 ligand binding and activation, FGFR1c ligand binding and activation, FGFR2 ligand binding and activation, FGFR2c ligand binding and activation, FGFR3 ligand binding and activation, FGFR3c ligand binding and activation, FGFR4 ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Gastric cancer - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, Phospholipase C-mediated cascade; FGFR3, Phospholipase C-mediated cascade; FGFR4, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: P11403
Entrez ID: 14175
|
Does Knockout of Gapdhs in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Gapdhs
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gapdhs (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: flagellated sperm motility, glucose metabolic process, glycolytic process, positive regulation of glycolytic process; MF: NAD binding, NADP binding, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; CC: cilium, cytoplasm, cytosol, motile cilium, sperm fibrous sheath, sperm principal piece
Pathways: Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, gluconeogenesis I, glycolysis I, glycolysis III
UniProt: Q64467
Entrez ID: 14447
|
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