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Does Knockout of Chsy1 in Regulatory T cell causally result in cell proliferation?
0
1,483
Knockout
Chsy1
cell proliferation
Regulatory T cell
Gene: Chsy1 (chondroitin sulfate synthase 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: bone morphogenesis, cartilage development, chondrocyte development, chondroitin sulfate proteoglycan biosynthetic process, negative regulation of ossification, positive regulation...
Does Knockout of Cd46 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,264
Knockout
Cd46
cell proliferation
Colonic Cancer Cell Line
Gene: Cd46 (CD46 antigen, complement regulatory protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: T cell mediated immunity, negative regulation of complement activation, classical pathway, negative regulation of gene expression, positive regulation of T cell prolif...
Does Knockout of Copz2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,277
Knockout
Copz2
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Copz2 (coatomer protein complex, subunit zeta 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: intra-Golgi vesicle-mediated transport, intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicl...
Does Knockout of Letm1 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,287
Knockout
Letm1
cell proliferation
Mouse kidney carcinoma cell
Gene: Letm1 (leucine zipper-EF-hand containing transmembrane protein 1) Type: protein-coding Summary: Enables calcium:proton antiporter activity. Involved in calcium export from the mitochondrion; mitochondrial calcium ion homeostasis; and protein complex oligomerization. Located in mitochondrial inner ...
Does Knockout of Idh2 in myoblast cell line causally result in protein/peptide distribution?
0
1,682
Knockout
Idh2
protein/peptide distribution
myoblast cell line
Gene: Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial) Type: protein-coding Summary: Enables isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in several processes, including NADP biosynthetic process; carboxylic acid metabolic process; and negative regulation of matrix metallo...
Does Knockout of Zfp964 in breast epithelium causally result in cell cycle progression?
0
1,469
Knockout
Zfp964
cell cycle progression
breast epithelium
Gene: Zfp964 (zinc finger protein 964) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA ...
Does Knockout of Unc13a in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,259
Knockout
Unc13a
cell proliferation
Mouse kidney carcinoma cell
Gene: Unc13a (unc-13 homolog A) Type: protein-coding Summary: No summary available. Gene Ontology: BP: SNARE complex assembly, amyloid-beta metabolic process, cell differentiation, chemical synaptic transmission, dense core granule docking, dense core granule priming, exocytosis, innervation, l...
Does Knockout of 4833420G17Rik in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
688
Knockout
4833420G17Rik
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: 4833420G17Rik (RIKEN cDNA 4833420G17 gene) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q3UJC8 Entrez ID: 67392
Does Knockout of Egr2 in Melanoma Cell Line causally result in cell proliferation?
0
1,838
Knockout
Egr2
cell proliferation
Melanoma Cell Line
Gene: Egr2 (early growth response 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Schwann cell differentiation, aorta development, brain segmentation, facial nerve structural organization, fat cell differentiation, gene expression, motor neuron axon guidance, myelinati...
Does Knockout of Gm21734 in macrophage causally result in phagocytosis?
0
1,889
Knockout
Gm21734
phagocytosis
macrophage
Gene: Gm21734 (predicted gene, 21734) Type: Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID:
Does Knockout of M6pr in Colonic Cancer Cell Line causally result in tumorigenicity?
0
2,177
Knockout
M6pr
tumorigenicity
Colonic Cancer Cell Line
Gene: M6pr (mannose-6-phosphate receptor, cation dependent) Type: protein-coding Summary: No summary available. Gene Ontology: BP: intracellular protein transport, lysosomal transport, protein targeting to lysosome, secretion of lysosomal enzymes; MF: protein binding, protein domain specific bi...
Does Knockout of Prr19 in Regulatory T cell causally result in cell proliferation?
0
1,483
Knockout
Prr19
cell proliferation
Regulatory T cell
Gene: Prr19 (proline rich 19) Type: protein-coding Summary: No summary available. Gene Ontology: BP: biological_process, meiotic cell cycle; CC: chromosome, nucleus Pathways: UniProt: B2RW88 Entrez ID: 623131
Does Knockout of Alkbh7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
83
Knockout
Alkbh7
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Alkbh7 (alkB homolog 7) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, fatty acid metabolic process, oxidative RNA demethylation, programmed cell death, regulation of lipid storage, regulation of mitochondrial membrane permeability involved in ...
Does Knockout of Pla2g4d in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,398
Knockout
Pla2g4d
protein/peptide accumulation
Microglial Cell Line
Gene: Pla2g4d (phospholipase A2, group IVD) Type: protein-coding Summary: No summary available. Gene Ontology: BP: fatty acid metabolic process, glycerophospholipid catabolic process, lipid catabolic process, lipid metabolic process, phospholipid catabolic process; MF: calcium ion binding, calc...
Does Knockout of Kctd5 in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Kctd5
cell viability
Immortal mouse chromaffin cells
Gene: Kctd5 (potassium channel tetramerisation domain containing 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein homooligomerization; MF: cullin family protein binding, identical protein binding...
Does Knockout of Flrt3 in Embryonic Stem Cell Line causally result in cell proliferation?
0
578
Knockout
Flrt3
cell proliferation
Embryonic Stem Cell Line
Gene: Flrt3 (fibronectin leucine rich transmembrane protein 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: axon guidance, cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, embryonic morphogenesis, fibroblast growth factor receptor signaling pat...
Does Knockout of Nyx in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,264
Knockout
Nyx
cell proliferation
Colonic Cancer Cell Line
Gene: Nyx (nyctalopin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: visual perception; MF: protein binding, signaling receptor activity; CC: dendrite, extracellular matrix, extracellular region, postsynapse Pathways: UniProt: P83503 Entrez ID...
Does Knockout of Msantd3 in myoblast cell line causally result in protein/peptide distribution?
0
1,682
Knockout
Msantd3
protein/peptide distribution
myoblast cell line
Gene: Msantd3 (Myb/SANT-like DNA-binding domain containing 3) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q9CR78 Entrez ID: 66665
Does Knockout of Smtn in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,265
Knockout
Smtn
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Smtn (smoothelin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of systemic arterial blood pressure, positive regulation of cardiac muscle contraction; CC: cytoplasm, cytoskeleton Pathways: UniProt: Q921U8 Entrez ID: ...
Does Knockout of Uqcr11 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
81
Knockout
Uqcr11
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Uqcr11 (ubiquinol-cytochrome c reductase, complex III subunit XI) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c; CC: membrane, mitochondrial inner membrane, mitochondrion, respirator...
Does Knockout of Cnbd2 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
0
1,077
Knockout
Cnbd2
protein/peptide accumulation
Mouse Embryonic Stem Cell
Gene: Cnbd2 (cyclic nucleotide binding domain containing 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: spermatogenesis; MF: cAMP binding, nucleotide binding; CC: cytoplasm, cytosol Pathways: UniProt: Q9D5U8 Entrez ID: 70873
Does Knockout of Gadd45gip1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
1
1,266
Knockout
Gadd45gip1
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Gadd45gip1 (growth arrest and DNA-damage-inducible, gamma interacting protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucleoplasm, nucleus, ribonucleoprotein complex, ribo...
Does Knockout of Capn10 in Embryonic Stem Cell Line causally result in cell proliferation?
0
2,477
Knockout
Capn10
cell proliferation
Embryonic Stem Cell Line
Gene: Capn10 (calpain 10) Type: protein-coding Summary: No summary available. Gene Ontology: BP: autophagy of mitochondrion, cellular response to insulin stimulus, mitochondrion organization, positive regulation of D-glucose import, positive regulation of apoptotic process, positive regulation ...
Does Knockout of C2cd4c in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,275
Knockout
C2cd4c
cell proliferation
Colonic Cancer Cell Line
Gene: C2cd4c (C2 calcium-dependent domain containing 4C) Type: protein-coding Summary: Is active in cytosol. Is expressed in several structures, including pancreas. Orthologous to human C2CD4C (C2 calcium dependent domain containing 4C). [provided by Alliance of Genome Resources, Jul 2025] Gene...
Does Knockout of Inpp5b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,280
Knockout
Inpp5b
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Inpp5b (inositol polyphosphate-5-phosphatase B) Type: protein-coding Summary: This gene encodes a member of the inositol polyphosphate-5-phosphatase (INPP5) family. This protein hydrolyzes the 5' phosphate from phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol-1,4,5-trisphosphate, whi...
Does Knockout of Gemin4 in Melanoma Cell Line causally result in cell proliferation?
0
2,492
Knockout
Gemin4
cell proliferation
Melanoma Cell Line
Gene: Gemin4 (gem nuclear organelle associated protein 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: rRNA processing, spliceosomal snRNP assembly; MF: ribonucleoprotein complex binding; CC: Cajal body, SMN complex, SMN-Sm protein complex, cytosol, nuclear body, nucle...
Does Knockout of Raver2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,259
Knockout
Raver2
cell proliferation
Mouse kidney carcinoma cell
Gene: Raver2 (ribonucleoprotein, PTB-binding 2) Type: protein-coding Summary: No summary available. Gene Ontology: MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm, nucleus Pathways: UniProt: Q7TPD6 Entrez ID: 242570
Does Knockout of Gm4847 in Melanoma Cell Line causally result in protein/peptide accumulation?
0
1,839
Knockout
Gm4847
protein/peptide accumulation
Melanoma Cell Line
Gene: Gm4847 (predicted gene 4847) Type: protein-coding Summary: No summary available. Gene Ontology: MF: N,N-dimethylaniline monooxygenase activity, NADP binding, flavin adenine dinucleotide binding, hypotaurine monooxygenase activity, monooxygenase activity, oxidoreductase activity, oxidoredu...
Does Knockout of F3 in Melanoma Cell Line causally result in tumorigenicity?
0
617
Knockout
F3
tumorigenicity
Melanoma Cell Line
Gene: F3 (coagulation factor III, tissue factor) Type: protein-coding Summary: This gene encodes a membrane-bound glycoprotein that forms the primary physiological initiator of the blood coagulation process following vascular damage. The encoded protein binds to coagulation factor VIIa and the ensuing c...
Does Knockout of Eif4a1 in breast epithelium causally result in cell cycle progression?
0
1,469
Knockout
Eif4a1
cell cycle progression
breast epithelium
Gene: Eif4a1 (eukaryotic translation initiation factor 4A1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cytoplasmic translational initiation, positive regulation of transcription by RNA polymerase II, translation, translational initiation; MF: ATP binding, ATP hydroly...
Does Knockout of Dll1 in macrophage causally result in phagocytosis?
0
1,890
Knockout
Dll1
phagocytosis
macrophage
Gene: Dll1 (delta like canonical Notch ligand 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Notch signaling pathway, Notch signaling pathway involved in arterial endothelial cell fate commitment, animal organ morphogenesis, astrocyte development, auditory receptor ce...
Does Knockout of Gpn1 in myoblast cell line causally result in protein/peptide distribution?
0
1,680
Knockout
Gpn1
protein/peptide distribution
myoblast cell line
Gene: Gpn1 (GPN-loop GTPase 1) Type: protein-coding Summary: Predicted to enable GTPase activity. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Is expressed in embryo; sublingual gland primordium; and submandibular gland primordium. Orthologous to human GPN1 (GPN-loop GTPase 1). [p...
Does Knockout of Hspe1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,174
Knockout
Hspe1
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Hspe1 (heat shock protein 1 (chaperonin 10)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein folding; MF: ATP binding, metal ion binding, protein folding chaperone, protein-folding chaperone binding, unfolded protein binding; CC: mitochondrial matrix, mitoch...
Does Knockout of Ube2m in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
1
685
Knockout
Ube2m
cell proliferation
Acute Myeloid Leukemia Cell Line
Gene: Ube2m (ubiquitin-conjugating enzyme E2M) Type: protein-coding Summary: Predicted to enable NEDD8 transferase activity and ubiquitin-protein transferase activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse; postsynapse; and presynapse. Is expressed in several...
Does Knockout of Wdr18 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,274
Knockout
Wdr18
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Wdr18 (WD repeat domain 18) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA-templated DNA replication, rRNA processing; CC: cytoplasm, dynein axonemal particle, nuclear pre-replicative complex, nucleolus, nucleoplasm, nucleus, rixosome complex Pathways:...
Does Knockout of Tbcd in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,290
Knockout
Tbcd
cell proliferation
Mouse kidney carcinoma cell
Gene: Tbcd (tubulin-specific chaperone d) Type: protein-coding Summary: No summary available. Gene Ontology: BP: adherens junction assembly, bicellular tight junction assembly, cell morphogenesis involved in neuron differentiation, microtubule cytoskeleton organization, mitotic cell cycle, nega...
Does Knockout of Mcm9 in Colonic Cancer Cell Line causally result in tumorigenicity?
0
2,177
Knockout
Mcm9
tumorigenicity
Colonic Cancer Cell Line
Gene: Mcm9 (minichromosome maintenance 9 homologous recombination repair factor) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, double-strand break repair via homologous recombination, female gamete generation, gamete gen...
Does Knockout of Ddx5 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
1
684
Knockout
Ddx5
cell proliferation
Acute Myeloid Leukemia Cell Line
Gene: Ddx5 (DEAD box helicase 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: BMP signaling pathway, RNA splicing, alternative mRNA splicing, via spliceosome, androgen receptor signaling pathway, circadian rhythm, epithelial to mesenchymal transition, estrogen receptor...
Does Knockout of Nacc2 in Melanoma Cell Line causally result in cell proliferation?
0
1,269
Knockout
Nacc2
cell proliferation
Melanoma Cell Line
Gene: Nacc2 (nucleus accumbens associated 2, BEN and BTB (POZ) domain containing) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of transcription...
Does Knockout of Mylk4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
687
Knockout
Mylk4
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Mylk4 (myosin light chain kinase family, member 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: sarcomere organization, signal transduction; MF: ATP binding, calcium/calmodulin-dependent protein kinase activity, kinase activity, myosin light chain kinase activity...
Does Knockout of Zfp37 in Pancreatic Cancer Cell Line causally result in response to chemicals?
0
2,359
Knockout
Zfp37
response to chemicals
Pancreatic Cancer Cell Line
Gene: Zfp37 (zinc finger protein 37) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, germ cell development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding tra...
Does Knockout of Tcfl5 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,283
Knockout
Tcfl5
cell proliferation
Mouse kidney carcinoma cell
Gene: Tcfl5 (transcription factor-like 5 (basic helix-loop-helix)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell differentiatio...
Does Knockout of Akr1b8 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,263
Knockout
Akr1b8
cell proliferation
Colonic Cancer Cell Line
Gene: Akr1b8 (aldo-keto reductase family 1, member B8) Type: protein-coding Summary: No summary available. Gene Ontology: BP: lipid metabolic process, polyol metabolic process, retinal metabolic process, retinol metabolic process; MF: NADP+ binding, NADPH binding, alcohol dehydrogenase (NADP+) ...
Does Knockout of Eif2s3y in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,275
Knockout
Eif2s3y
cell proliferation
Colonic Cancer Cell Line
Gene: Eif2s3y (eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cytoplasmic translational initiation, formation of translation preinitiation complex, positive regulation of male gonad developm...
Does Knockout of BC005537 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,261
Knockout
BC005537
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: BC005537 (cDNA sequence BC005537) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q99LU8 Entrez ID: 79555
Does Knockout of Phrf1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
0
345
Knockout
Phrf1
cell proliferation
Embryonic Fibroblast Cell Line
Gene: Phrf1 (PHD and ring finger domains 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mRNA processing, transcription by RNA polymerase II; MF: RNA polymerase binding, metal ion binding, protein domain specific binding, zinc ion binding Pathways: U...
Does Knockout of Ankrd37 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,267
Knockout
Ankrd37
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Ankrd37 (ankyrin repeat domain 37) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cytoplasm, cytosol, male germ cell nucleus, mitochondrion, nucleoplasm, nucleus Pathways: UniProt: Q569N2 Entrez ID: 654824
Does Knockout of Ggps1 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
1
1,521
Knockout
Ggps1
protein/peptide accumulation
Embryonic Fibroblast Cell Line
Gene: Ggps1 (geranylgeranyl diphosphate synthase 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: farnesyl diphosphate biosynthetic process, geranyl diphosphate biosynthetic process, geranylgeranyl diphosphate biosynthetic process, isoprenoid biosynthetic process, isopr...
Does Knockout of Foxo3 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,276
Knockout
Foxo3
cell proliferation
Colonic Cancer Cell Line
Gene: Foxo3 (forkhead box O3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, antral ovarian follicle growth, apoptotic process, brain morphogenesis, cellular response to amyloid-beta, cellular response to co...
Does Knockout of Gucy1b2 in myoblast cell line causally result in protein/peptide distribution?
0
1,680
Knockout
Gucy1b2
protein/peptide distribution
myoblast cell line
Gene: Gucy1b2 (guanylate cyclase 1, soluble, beta 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cGMP biosynthetic process, cGMP-mediated signaling, cyclic nucleotide biosynthetic process, intracellular signal transduction, response to oxygen levels; MF: GTP binding, ...
Does Knockout of Wfs1 in myoblast cell line causally result in protein/peptide distribution?
0
1,680
Knockout
Wfs1
protein/peptide distribution
myoblast cell line
Gene: Wfs1 (wolframin ER transmembrane glycoprotein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: ER overload response, ERAD pathway, calcium ion homeostasis, endoplasmic reticulum calcium ion homeostasis, endoplasmic reticulum unfolded protein response, glucose homeos...
Does Knockout of Kdm5c in Melanoma Cell Line causally result in cell proliferation?
0
1,270
Knockout
Kdm5c
cell proliferation
Melanoma Cell Line
Gene: Kdm5c (lysine demethylase 5C) Type: protein-coding Summary: No summary available. Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated tra...
Does Knockout of Diaph1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
167
Knockout
Diaph1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Diaph1 (diaphanous related formin 1) Type: protein-coding Summary: This gene encodes a member of the formin family of proteins that play important roles in cytoskeletal rearragnement by nucleation of actin filaments. Mice lacking the encoded protein develop age-dependent myeloproliferative defects...
Does Knockout of Ttk in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,279
Knockout
Ttk
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Ttk (Ttk protein kinase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: chromosome segregation, female meiosis chromosome segregation, meiotic spindle assembly checkpoint signaling, mitotic spindle assembly checkpoint signaling, nuclear chromosome segregation, nucl...
Does Knockout of Pigs in Colonic Cancer Cell Line causally result in tumorigenicity?
0
2,180
Knockout
Pigs
tumorigenicity
Colonic Cancer Cell Line
Gene: Pigs (phosphatidylinositol glycan anchor biosynthesis, class S) Type: protein-coding Summary: Involved in attachment of GPI anchor to protein. Part of GPI-anchor transamidase complex. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and uri...
Does Knockout of Hibch in myoblast cell line causally result in protein/peptide distribution?
0
1,684
Knockout
Hibch
protein/peptide distribution
myoblast cell line
Gene: Hibch (3-hydroxyisobutyryl-Coenzyme A hydrolase) Type: protein-coding Summary: Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in 3-hydroxyisobutryl-CoA hydrola...
Does Knockout of Mgme1 in Lymphoma Cell Line causally result in response to chemicals?
0
1,555
Knockout
Mgme1
response to chemicals
Lymphoma Cell Line
Gene: Mgme1 (mitochondrial genome maintenance exonuclease 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, mitochondrial DNA repair, mitochondrial DNA replication; MF: 5'-flap endonuclease activity, exonuclease activity, hydrolase activi...
Does Knockout of Crisp3 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,264
Knockout
Crisp3
cell proliferation
Colonic Cancer Cell Line
Gene: Crisp3 (cysteine-rich secretory protein 3) Type: protein-coding Summary: Predicted to be involved in sexual reproduction. Predicted to be located in extracellular region and transport vesicle. Predicted to be active in extracellular space. Is expressed in sublingual gland and submandibular gland. ...
Does Knockout of Cyp2f2 in Regulatory T cell causally result in cell proliferation?
0
1,484
Knockout
Cyp2f2
cell proliferation
Regulatory T cell
Gene: Cyp2f2 (cytochrome P450, family 2, subfamily f, polypeptide 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: epoxygenase P450 pathway, naphthalene catabolic process, response to toxic substance, trichloroethylene metabolic process, xenobiotic metabolic process; MF...
Does Knockout of Fam168a in Regulatory T cell causally result in protein/peptide accumulation?
0
1,482
Knockout
Fam168a
protein/peptide accumulation
Regulatory T cell
Gene: Fam168a (family with sequence similarity 168, member A) Type: protein-coding Summary: No summary available. Gene Ontology: BP: positive regulation of base-excision repair Pathways: UniProt: Q8BGZ2 Entrez ID: 319604
Does Knockout of Ccdc54 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,275
Knockout
Ccdc54
cell proliferation
Colonic Cancer Cell Line
Gene: Ccdc54 (coiled-coil domain containing 54) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q9DAL3 Entrez ID: 69339
Does Knockout of Alox12b in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
Alox12b
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Alox12b (arachidonate 12-lipoxygenase, 12R type) Type: protein-coding Summary: This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene can prevent the formation of the epidermal permeability barrier and cause an ichthyo...
Does Knockout of Bpi in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,399
Knockout
Bpi
protein/peptide accumulation
Microglial Cell Line
Gene: Bpi (bactericidal permeablility increasing protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, cellular response to lipopolysaccharide, defense response to ...
Does Knockout of Tcp1 in Embryonic Fibroblast Cell Line causally result in autophagy?
1
1,044
Knockout
Tcp1
autophagy
Embryonic Fibroblast Cell Line
Gene: Tcp1 (t-complex protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of establishment of protein localization to telomere, positive regulation of telomerase RNA localization to Cajal body, positive regula...
Does Knockout of Tmprss11g in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
Tmprss11g
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Tmprss11g (transmembrane protease, serine 11g) Type: protein-coding Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Orthologous to human TMPRSS11GP (transmembrane serine protease 11G, pseudogene)....
Does Knockout of Pira1 in myoblast cell line causally result in protein/peptide distribution?
0
1,684
Knockout
Pira1
protein/peptide distribution
myoblast cell line
Gene: Pira1 (paired-Ig-like receptor A1) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: B cell receptor signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse) UniProt: Entrez ID: 18722
Does Knockout of Rhox6 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,260
Knockout
Rhox6
cell proliferation
Mouse kidney carcinoma cell
Gene: Rhox6 (reproductive homeobox 6) Type: protein-coding Summary: No summary available. Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator acti...
Does Knockout of Dhrs7c in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
688
Knockout
Dhrs7c
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Dhrs7c (dehydrogenase/reductase 7C) Type: protein-coding Summary: Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in D-glucose import; intracellular calcium ion homeostasis; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Located in lo...
Does Knockout of Ppp2r1b in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,264
Knockout
Ppp2r1b
cell proliferation
Colonic Cancer Cell Line
Gene: Ppp2r1b (protein phosphatase 2, regulatory subunit A, beta) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic process involved in morphogenesis, meiotic sister chromatid cohesion, centromeric, positive regulation of extrinsic apoptotic signaling pathway in a...
Does Knockout of Plekhm3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,280
Knockout
Plekhm3
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Plekhm3 (pleckstrin homology domain containing, family M, member 3) Type: protein-coding Summary: No summary available. Gene Ontology: MF: metal ion binding, protein binding, zinc ion binding; CC: Golgi apparatus, cytoplasm, membrane, plasma membrane Pathways: UniProt: ...
Does Knockout of Msr1 in Melanoma Cell Line causally result in cell proliferation?
0
1,282
Knockout
Msr1
cell proliferation
Melanoma Cell Line
Gene: Msr1 (macrophage scavenger receptor 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: amyloid-beta clearance, cholesterol transport, endocytosis, establishment of localization in cell, lipoprotein transport, negative regulation of gene expression, phagocytosis, eng...
Does Knockout of Cox7a2l in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,261
Knockout
Cox7a2l
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Cox7a2l (cytochrome c oxidase subunit 7A2 like) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, mitochondrial respirasome assembly; MF: protein-macromolecule adaptor activity; CC: membrane, mitochondrial inne...
Does Knockout of Galnt3 in macrophage causally result in phagocytosis?
0
1,890
Knockout
Galnt3
phagocytosis
macrophage
Gene: Galnt3 (polypeptide N-acetylgalactosaminyltransferase 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic process, cell maturation, chondrocyte development, chondroitin sulfate proteoglycan biosynthetic process, endochondral ossification, gene expression, l...
Does Knockout of Rttn in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
1
161
Knockout
Rttn
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Rttn (rotatin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: centriole replication, centriole-centriole cohesion, ciliary basal body organization, cilium organization, determination of left/right symmetry; CC: cell projection, centriole, centrosome, ciliary basal ...
Does Knockout of Dmrtc1b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Dmrtc1b
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Dmrtc1b (DMRT-like family C1b) Type: protein-coding Summary: No summary available. Gene Ontology: MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: nucleus Pathways: UniP...
Does Knockout of Fbxo33 in Melanoma Cell Line causally result in cell proliferation?
0
1,269
Knockout
Fbxo33
cell proliferation
Melanoma Cell Line
Gene: Fbxo33 (F-box protein 33) Type: protein-coding Summary: No summary available. Gene Ontology: BP: positive regulation of protein ubiquitination, protein ubiquitination Pathways: UniProt: Q8VE08 Entrez ID: 70611
Does Knockout of Bnc1 in breast epithelium causally result in cell cycle progression?
0
1,470
Knockout
Bnc1
cell cycle progression
breast epithelium
Gene: Bnc1 (basonuclin zinc finger protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, chromosome organization, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of ...
Does Knockout of Irf5 in myoblast cell line causally result in protein/peptide distribution?
0
1,682
Knockout
Irf5
protein/peptide distribution
myoblast cell line
Gene: Irf5 (interferon regulatory factor 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular response to muramyl dipeptide, cellular response to peptidoglycan, cellular response to virus, cytokine-mediated signaling pathway, defense response to virus, immune syste...
Does Knockout of Fras1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,279
Knockout
Fras1
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Fras1 (Fraser extracellular matrix complex subunit 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: anatomical structure morphogenesis, animal organ development, cell communication, embryonic limb morphogenesis, metanephros morphogenesis, morphogenesis of an epith...
Does Knockout of Herc4 in Neuroblastoma Cell Line causally result in response to virus?
0
1,422
Knockout
Herc4
response to virus
Neuroblastoma Cell Line
Gene: Herc4 (hect domain and RLD 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, negative regulation of smoothened signaling pathway, protein ubiquitination, spermatogenesis, ubiquitin-dependent protein catabolic process; MF: transferase activity,...
Does Knockout of Taf10 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
1
2,308
Knockout
Taf10
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Taf10 (TATA-box binding protein associated factor 10) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA-templated transcription initiation, G1/S transition of mitotic cell cycle, RNA polymerase II preinitiation complex assembly, SAGA complex assembly, allantois de...
Does Knockout of Tigar in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,398
Knockout
Tigar
protein/peptide accumulation
Microglial Cell Line
Gene: Tigar (Trp53 induced glycolysis regulatory phosphatase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, apoptotic process, autophagy, cellular response to cobalt ion, cellular response to hypoxia, fructose 2,6-bisphosphate metabolic process, int...
Does Knockout of Mmp16 in Colonic Cancer Cell Line causally result in cell proliferation?
0
2,176
Knockout
Mmp16
cell proliferation
Colonic Cancer Cell Line
Gene: Mmp16 (matrix metallopeptidase 16) Type: protein-coding Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded prepropr...
Does Knockout of Nkd1 in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Nkd1
cell cycle progression
breast epithelium
Gene: Nkd1 (naked cuticle 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Wnt signaling pathway, axis elongation, cell differentiation, convergent extension, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, positive ...
Does Knockout of Gzf1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
2,170
Knockout
Gzf1
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Gzf1 (GDNF-inducible zinc finger protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: branching involved in ureteric bud morphogenesis, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regu...
Does Knockout of Mrpl39 in Microglial Cell Line causally result in response to virus?
0
1,438
Knockout
Mrpl39
response to virus
Microglial Cell Line
Gene: Mrpl39 (mitochondrial ribosomal protein L39) Type: protein-coding Summary: No summary available. Gene Ontology: BP: mitochondrial translation, mitochondrion organization, translation; MF: nucleotide binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondri...
Does Knockout of Car5a in Colonic Cancer Cell Line causally result in cell proliferation?
0
2,179
Knockout
Car5a
cell proliferation
Colonic Cancer Cell Line
Gene: Car5a (carbonic anhydrase 5a, mitochondrial) Type: protein-coding Summary: Enables carbonate dehydratase activity. Predicted to act upstream of or within gluconeogenesis. Located in mitochondrion. Is expressed in inner ear; liver; metanephros; and trunk. Orthologous to human CA5A (carbonic anhydra...
Does Knockout of Cmtm2a in Embryonic Stem Cell Line causally result in cell proliferation?
0
579
Knockout
Cmtm2a
cell proliferation
Embryonic Stem Cell Line
Gene: Cmtm2a (CKLF-like MARVEL transmembrane domain containing 2A) Type: protein-coding Summary: Enables transcription corepressor activity. Acts upstream of or within negative regulation of DNA-templated transcription and regulation of testosterone biosynthetic process. Located in cytoplasm and nucleus...
Does Knockout of Me2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,284
Knockout
Me2
cell proliferation
Mouse kidney carcinoma cell
Gene: Me2 (malic enzyme 2, NAD(+)-dependent, mitochondrial) Type: protein-coding Summary: No summary available. Gene Ontology: BP: malate metabolic process, pyruvate metabolic process, regulation of NADP metabolic process; MF: NAD binding, catalytic activity, malate dehydrogenase (decarboxylati...
Does Knockout of Exoc8 in Regulatory T cell causally result in cell proliferation?
0
1,483
Knockout
Exoc8
cell proliferation
Regulatory T cell
Gene: Exoc8 (exocyst complex component 8) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Golgi to plasma membrane transport, endosome organization, exocytosis, extracellular matrix disassembly, intracellular protein localization, membrane fission, mitotic cytokinesis, pr...
Does Knockout of Fhod1 in Melanoma Cell Line causally result in cell proliferation?
0
1,282
Knockout
Fhod1
cell proliferation
Melanoma Cell Line
Gene: Fhod1 (formin homology 2 domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: actin filament organization, establishment of centrosome localization, nuclear migration, positive regulation of stress fiber assembly, positive regulation of transcription...
Does Knockout of Prdm9 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,290
Knockout
Prdm9
cell proliferation
Mouse kidney carcinoma cell
Gene: Prdm9 (PR domain containing 9) Type: protein-coding Summary: No summary available. Gene Ontology: BP: chromatin organization, chromatin remodeling, double-strand break repair involved in meiotic recombination, female gamete generation, homologous chromosome pairing at meiosis, homologous ...
Does Knockout of Lce1f in myoblast cell line causally result in protein/peptide distribution?
0
1,683
Knockout
Lce1f
protein/peptide distribution
myoblast cell line
Gene: Lce1f (late cornified envelope 1F) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q9D1I4, B9EJP6 Entrez ID: 67828
Does Knockout of Supt6 in Colonic Cancer Cell Line causally result in tumorigenicity?
0
2,177
Knockout
Supt6
tumorigenicity
Colonic Cancer Cell Line
Gene: Supt6 (SPT6, histone chaperone and transcription elongation factor) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA splicing, blastocyst formation, mRNA processing, mRNA transport, nucleobase-containing compound metabolic process, nucleosome organization, positi...
Does Knockout of Nfatc2ip in macrophage causally result in response to bacteria?
0
2,211
Knockout
Nfatc2ip
response to bacteria
macrophage
Gene: Nfatc2ip (nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: positive regulation of transcription by RNA polymerase II; CC: cytoplasm, nucleus Pathways: Un...
Does Knockout of 4930553M12Rik in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,265
Knockout
4930553M12Rik
cell proliferation
Mammary Gland Tumor Cell Line
Gene: 4930553M12Rik (RIKEN cDNA 4930553M12 gene) Type: Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID:
Does Knockout of Eno1 in Melanoma Cell Line causally result in cell proliferation?
0
1,281
Knockout
Eno1
cell proliferation
Melanoma Cell Line
Gene: Eno1 (enolase 1, alpha non-neuron) Type: protein-coding Summary: No summary available. Gene Ontology: BP: canonical glycolysis, cellular response to interleukin-7, gluconeogenesis, glyceraldehyde-3-phosphate biosynthetic process, glycolytic process, in utero embryonic development, negativ...
Does Knockout of Omd in Melanoma Cell Line causally result in cell proliferation?
0
1,838
Knockout
Omd
cell proliferation
Melanoma Cell Line
Gene: Omd (osteomodulin) Type: protein-coding Summary: No summary available. Gene Ontology: CC: extracellular matrix, extracellular region, extracellular space Pathways: Glycosaminoglycan metabolism, Keratan sulfate biosynthesis, Keratan sulfate degradation, Keratan sulfate/keratin met...
Does Knockout of Fgf4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,267
Knockout
Fgf4
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Fgf4 (fibroblast growth factor 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: apoptotic process involved in morphogenesis, cartilage condensation, cell differentiation, cellular response to leukemia inhibitory factor, chondroblast differentiation, cranial suture...
Does Knockout of Gapdhs in myoblast cell line causally result in protein/peptide distribution?
0
1,683
Knockout
Gapdhs
protein/peptide distribution
myoblast cell line
Gene: Gapdhs (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic) Type: protein-coding Summary: No summary available. Gene Ontology: BP: flagellated sperm motility, glucose metabolic process, glycolytic process, positive regulation of glycolytic process; MF: NAD binding, NADP binding, glyc...