prompt
string
hit
int64
screen_id
int64
crispr_strategy
string
gene
string
phenotype
string
cell_type
string
gene_context
string
Does Knockout of Cdadc1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,277
Knockout
Cdadc1
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Cdadc1 (cytidine and dCMP deaminase domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: MF: catalytic activity, cytidine deaminase activity, dCMP deaminase activity, hydrolase activity, importin-alpha family protein binding, metal ion binding, protein h...
Does Knockout of Stard6 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,276
Knockout
Stard6
cell proliferation
Colonic Cancer Cell Line
Gene: Stard6 (StAR related lipid transfer domain containing 6) Type: protein-coding Summary: Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Orthologous to human STARD6 (StAR related lipid transfer domain containing 6). [provided by Alliance of Genome Resou...
Does Knockout of Pip4k2c in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,279
Knockout
Pip4k2c
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Pip4k2c (phosphatidylinositol-5-phosphate 4-kinase, type II, gamma) Type: protein-coding Summary: No summary available. Gene Ontology: BP: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process, autophagosome-lysosome fusion, lipid metabolic process, negative regulation of i...
Does Knockout of Pla2g4d in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
1,565
Knockout
Pla2g4d
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Pla2g4d (phospholipase A2, group IVD) Type: protein-coding Summary: No summary available. Gene Ontology: BP: fatty acid metabolic process, glycerophospholipid catabolic process, lipid catabolic process, lipid metabolic process, phospholipid catabolic process; MF: calcium ion binding, calc...
Does Knockout of Abcc5 in Regulatory T cell causally result in cell proliferation?
0
2,127
Knockout
Abcc5
cell proliferation
Regulatory T cell
Gene: Abcc5 (ATP-binding cassette, sub-family C member 5) Type: protein-coding Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC...
Does Knockout of Bin2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,280
Knockout
Bin2
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Bin2 (bridging integrator 2) Type: protein-coding Summary: Predicted to enable phospholipid binding activity. Predicted to be involved in several processes, including phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Predicted to be located in anchoring junction; cell co...
Does Knockout of Stxbp4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Stxbp4
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Stxbp4 (syntaxin binding protein 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, cellular response to type II interferon, insulin receptor signaling pathway, positive regulation of cell cycle G1/S phase transition, positive regulation of kera...
Does Knockout of Gm6811 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,286
Knockout
Gm6811
cell proliferation
Mouse kidney carcinoma cell
Gene: Gm6811 (sperm motility kinase Y pseudogene) Type: pseudo Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID: 627924
Does Knockout of Ptges in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,175
Knockout
Ptges
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Ptges (prostaglandin E synthase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular oxidant detoxification, cyclooxygenase pathway, fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, negative regulation of cell population p...
Does Knockout of Slc1a7 in Melanoma Cell Line causally result in cell proliferation?
0
1,281
Knockout
Slc1a7
cell proliferation
Melanoma Cell Line
Gene: Slc1a7 (solute carrier family 1 (glutamate transporter), member 7) Type: protein-coding Summary: No summary available. Gene Ontology: BP: L-glutamate transmembrane transport, chloride transmembrane transport, excitatory postsynaptic potential, monoatomic anion transmembrane transport, neu...
Does Knockout of Tmed3 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Tmed3
protein/peptide accumulation
Embryonic Cell Line
Gene: Tmed3 (transmembrane p24 trafficking protein 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport; CC: COPI vesicle coat, COPI-coated vesi...
Does Knockout of P2ry13 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,275
Knockout
P2ry13
cell proliferation
Colonic Cancer Cell Line
Gene: P2ry13 (purinergic receptor P2Y, G-protein coupled 13) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled purinergic nucleotide receptor signaling pathway, G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled purine...
Does Knockout of Gm1604b in Regulatory T cell causally result in protein/peptide accumulation?
0
1,482
Knockout
Gm1604b
protein/peptide accumulation
Regulatory T cell
Gene: Gm1604b (predicted gene 1604b) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q3TRG0 Entrez ID: 381059
Does Knockout of Dolpp1 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,482
Knockout
Dolpp1
protein/peptide accumulation
Regulatory T cell
Gene: Dolpp1 (dolichyl pyrophosphate phosphatase 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein N-linked glycosylation, protein glycosylation; MF: dolichyldiphosphatase activity, hydrolase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, me...
Does Knockout of Rnf220 in Microglial Cell Line causally result in response to virus?
0
1,439
Knockout
Rnf220
response to virus
Microglial Cell Line
Gene: Rnf220 (ring finger protein 220) Type: protein-coding Summary: Enables ubiquitin protein ligase activity. Involved in protein autoubiquitination and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within nervous system development; positive regulation of D...
Does Knockout of Tll1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,278
Knockout
Tll1
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Tll1 (tolloid-like) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, dorsal/ventral pattern formation, protein processing, proteolysis; MF: calcium ion binding, collagen binding, hydrolase activity, metal ion binding, metalloendopeptidase activi...
Does Knockout of Cd3e in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
1,130
Knockout
Cd3e
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Cd3e (CD3 antigen, epsilon polypeptide) Type: protein-coding Summary: No summary available. Gene Ontology: BP: T cell costimulation, T cell receptor signaling pathway, adaptive immune response, apoptotic signaling pathway, cell surface receptor signaling pathway, cerebellum development, d...
Does Knockout of Cacna2d1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
1,130
Knockout
Cacna2d1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Cacna2d1 (calcium channel, voltage-dependent, alpha2/delta subunit 1) Type: protein-coding Summary: This gene encodes a regulatory component of the voltage-dependent calcium channel complex. The product of this gene is a proprotein that is proteolytically processed into alpha-2 and delta subunits,...
Does Knockout of Wnk1 in Melanoma Cell Line causally result in protein/peptide accumulation?
0
1,839
Knockout
Wnk1
protein/peptide accumulation
Melanoma Cell Line
Gene: Wnk1 (WNK lysine deficient protein kinase 1) Type: protein-coding Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular chloride ion homeostasis; and lymphocyte migration into lymph node. Acts upst...
Does Knockout of Padi1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,268
Knockout
Padi1
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Padi1 (peptidyl arginine deiminase, type I) Type: protein-coding Summary: No summary available. Gene Ontology: MF: calcium ion binding, hydrolase activity, metal ion binding, protein-arginine deiminase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus Pathways: Chromatin mod...
Does Knockout of Pdha1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,279
Knockout
Pdha1
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Pdha1 (pyruvate dehydrogenase E1 alpha 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: glucose metabolic process, pyruvate decarboxylation to acetyl-CoA, tricarboxylic acid cycle; MF: metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on ...
Does Knockout of Man2c1 in Regulatory T cell causally result in cell proliferation?
0
1,484
Knockout
Man2c1
cell proliferation
Regulatory T cell
Gene: Man2c1 (mannosidase, alpha, class 2C, member 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: carbohydrate metabolic process, mannose metabolic process, oligosaccharide catabolic process; MF: alpha-mannosidase activity, carbohydrate binding, catalytic activity, hy...
Does Knockout of Prol1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
161
Knockout
Prol1
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Prol1 (proline rich, lacrimal 1) Type: protein-coding Summary: No summary available. Gene Ontology: CC: membrane, plasma membrane Pathways: UniProt: E9PYQ4 Entrez ID: 17830
Does Knockout of Dus4l in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Dus4l
cell viability
Immortal mouse chromaffin cells
Gene: Dus4l (dihydrouridine synthase 4 like) Type: protein-coding Summary: No summary available. Gene Ontology: BP: tRNA dihydrouridine synthesis, tRNA processing; MF: flavin adenine dinucleotide binding, oxidoreductase activity, tRNA dihydrouridine synthase activity, tRNA-dihydrouridine20a syn...
Does Knockout of Ypel1 in Melanoma Cell Line causally result in cell proliferation?
0
2,488
Knockout
Ypel1
cell proliferation
Melanoma Cell Line
Gene: Ypel1 (yippee like 1) Type: protein-coding Summary: No summary available. Gene Ontology: MF: metal ion binding, molecular_function; CC: cellular_component, nucleus Pathways: UniProt: Q9ESC7 Entrez ID: 106369
Does Knockout of Phox2b in Embryonic Stem Cell Line causally result in cell proliferation?
0
579
Knockout
Phox2b
cell proliferation
Embryonic Stem Cell Line
Gene: Phox2b (paired-like homeobox 2b) Type: protein-coding Summary: No summary available. Gene Ontology: BP: autonomic nervous system development, brainstem development, cell development, cell differentiation in hindbrain, cellular response to BMP stimulus, cellular response to carbon dioxide,...
Does Knockout of Samd7 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
2,403
Knockout
Samd7
protein/peptide accumulation
Embryonic Cell Line
Gene: Samd7 (sterile alpha motif domain containing 7) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of gene expression, epigenetic, negative regulation of tra...
Does Knockout of Acsl4 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
0
1,077
Knockout
Acsl4
protein/peptide accumulation
Mouse Embryonic Stem Cell
Gene: Acsl4 (acyl-CoA synthetase long-chain family member 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: alpha-linolenic acid metabolic process, dendritic spine development, embryonic process involved in female pregnancy, fatty acid derivative biosynthetic process, fa...
Does Knockout of Bet1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,268
Knockout
Bet1
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Bet1 (Bet1 golgi vesicular membrane trafficking protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor ...
Does Knockout of Itpr3 in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Itpr3
cell viability
Immortal mouse chromaffin cells
Gene: Itpr3 (inositol 1,4,5-triphosphate receptor 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium ion homeostasis, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cellular res...
Does Knockout of Plxdc2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,307
Knockout
Plxdc2
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Plxdc2 (plexin domain containing 2) Type: protein-coding Summary: Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; inner ear; limb; skin; and trunk mesenchyme. Orthologous to human PLXDC2 (plexin domain containing 2). [provi...
Does Knockout of Acox1 in Embryonic Stem Cell Line causally result in cell proliferation?
0
578
Knockout
Acox1
cell proliferation
Embryonic Stem Cell Line
Gene: Acox1 (acyl-Coenzyme A oxidase 1, palmitoyl) Type: protein-coding Summary: This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-co...
Does Knockout of Actl11 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Actl11
protein/peptide accumulation
Embryonic Cell Line
Gene: Actl11 (actin-like 11) Type: protein-coding Summary: No summary available. Gene Ontology: CC: actin cytoskeleton, cytoskeleton Pathways: UniProt: Q9D5V1 Entrez ID: 67722
Does Knockout of Timm10 in Embryonic Stem Cell Line causally result in cell proliferation?
1
579
Knockout
Timm10
cell proliferation
Embryonic Stem Cell Line
Gene: Timm10 (translocase of inner mitochondrial membrane 10) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein transport; MF: membrane insertase activity, metal ion binding, protein homodimerization activity, pro...
Does Knockout of Utf1 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,570
Knockout
Utf1
protein/peptide accumulation
Regulatory T cell
Gene: Utf1 (undifferentiated embryonic cell transcription factor 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: positive regulation of transcription by RNA polymerase II; MF: HMG box domain binding, TBP-class protein binding, protein binding, transcription coactivator...
Does Knockout of Car13 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,277
Knockout
Car13
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Car13 (carbonic anhydrase 13) Type: protein-coding Summary: No summary available. Gene Ontology: MF: carbonate dehydratase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytoplasm, cytosol, myelin sheath Pathways: Metabolism, Nitrogen metabolism - Mus musculus...
Does Knockout of Pcdhga4 in Melanoma Cell Line causally result in cell proliferation?
0
1,281
Knockout
Pcdhga4
cell proliferation
Melanoma Cell Line
Gene: Pcdhga4 (protocadherin gamma subfamily A, 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, pl...
Does Knockout of Eif4a3 in Colonic Cancer Cell Line causally result in cell proliferation?
0
2,179
Knockout
Eif4a3
cell proliferation
Colonic Cancer Cell Line
Gene: Eif4a3 (eukaryotic translation initiation factor 4A3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA splicing, embryonic cranial skeleton morphogenesis, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, negative regulati...
Does Knockout of Vmp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,289
Knockout
Vmp1
cell proliferation
Mouse kidney carcinoma cell
Gene: Vmp1 (vacuole membrane protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Golgi organization, autophagosome assembly, autophagosome membrane docking, autophagy, cell adhesion, cell junction assembly, cell-cell adhesion, embryo implantation, lipid transport, ...
Does Knockout of Gna15 in Embryonic Stem Cell Line causally result in cell proliferation?
0
578
Knockout
Gna15
cell proliferation
Embryonic Stem Cell Line
Gene: Gna15 (guanine nucleotide binding protein, alpha 15) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, action potential, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, calcium-mediated signaling...
Does Knockout of Slc39a10 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,308
Knockout
Slc39a10
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Slc39a10 (solute carrier family 39 (zinc transporter), member 10) Type: protein-coding Summary: No summary available. Gene Ontology: BP: bicarbonate transport, epithelial to mesenchymal transition, intracellular monoatomic cation homeostasis, intracellular zinc ion homeostasis, metal ion ...
Does Knockout of Exoc5 in Microglial Cell Line causally result in protein/peptide distribution?
0
1,585
Knockout
Exoc5
protein/peptide distribution
Microglial Cell Line
Gene: Exoc5 (exocyst complex component 5) Type: protein-coding Summary: Predicted to enable small GTPase binding activity. Involved in protein localization to plasma membrane. Acts upstream of or within with a positive effect on establishment of planar polarity. Acts upstream of or within with a negativ...
Does Knockout of Tsc22d4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
167
Knockout
Tsc22d4
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Tsc22d4 (Tsc22 domain family, member 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: glucose homeostasis, negative regulation of transcription by RNA polymerase II, neuron cellular homeostasis, neuron projection extension, regulation of transcription by RNA polym...
Does Knockout of Sgsm1 in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Sgsm1
cell viability
Immortal mouse chromaffin cells
Gene: Sgsm1 (small G protein signaling modulator 1) Type: protein-coding Summary: Enables small GTPase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle membrane. Is expressed in several structures, including brain and ...
Does Knockout of Pomt2 in Melanoma Cell Line causally result in cell proliferation?
0
2,488
Knockout
Pomt2
cell proliferation
Melanoma Cell Line
Gene: Pomt2 (protein-O-mannosyltransferase 2) Type: protein-coding Summary: This gene encodes an integral membrane protein that belongs to the dolichyl-phosphate-mannose-protein mannosyltransferase family. The encoded enzyme is found in the membrane of the endoplasmic reticulum. This protein is a compon...
Does Knockout of Zfp672 in Melanoma Cell Line causally result in cell proliferation?
0
1,269
Knockout
Zfp672
cell proliferation
Melanoma Cell Line
Gene: Zfp672 (zinc finger protein 672) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory regi...
Does Knockout of Dtx4 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,263
Knockout
Dtx4
cell proliferation
Colonic Cancer Cell Line
Gene: Dtx4 (deltex 4, E3 ubiquitin ligase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Notch signaling pathway, antiviral innate immune response, innate immune response, negative regulation of innate immune response, proteasomal protein catabolic process, proteasome-m...
Does Knockout of Exosc1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,274
Knockout
Exosc1
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Exosc1 (exosome component 1) Type: protein-coding Summary: Predicted to enable RNA binding activity. Predicted to be involved in RNA catabolic process and RNA processing. Predicted to be located in cytosol and nucleolus. Predicted to be part of nuclear exosome (RNase complex). Predicted to be acti...
Does Knockout of Prtn3 in Melanoma Cell Line causally result in cell proliferation?
0
1,269
Knockout
Prtn3
cell proliferation
Melanoma Cell Line
Gene: Prtn3 (proteinase 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell-cell junction maintenance, collagen catabolic process, mature conventional dendritic cell differentiation, membrane protein ectodomain proteolysis, negative regulation of phagocytosis, neutrop...
Does Knockout of Caprin1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,266
Knockout
Caprin1
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Caprin1 (cell cycle associated protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, deadenylation-dependent decapping of nuclear-transcribed mRNA, generation of neurons, intracellular mRNA localization, membraneless organelle assembly, ne...
Does Knockout of Pex2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
82
Knockout
Pex2
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Pex2 (peroxisomal biogenesis factor 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: bile acid biosynthetic process, cellular response to reactive oxygen species, cholesterol homeostasis, fatty acid beta-oxidation, negative regulation of epithelial cell proliferat...
Does Knockout of Acadl in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,398
Knockout
Acadl
protein/peptide accumulation
Microglial Cell Line
Gene: Acadl (acyl-Coenzyme A dehydrogenase, long-chain) Type: protein-coding Summary: This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-dou...
Does Knockout of Pgd in Melanoma Cell Line causally result in protein/peptide accumulation?
0
1,839
Knockout
Pgd
protein/peptide accumulation
Melanoma Cell Line
Gene: Pgd (phosphogluconate dehydrogenase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: D-gluconate metabolic process, NADP+ metabolic process, NADPH regeneration, pentose biosynthetic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch; MF: NAD...
Does Knockout of Usp17la in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Usp17la
cell viability
Immortal mouse chromaffin cells
Gene: Usp17la (ubiquitin specific peptidase 17-like A) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of apoptotic process, regulation of protein stability; MF: RNA binding, cysteine-type deubiquitinase activity, cysteine...
Does Knockout of Gtf2e2 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,398
Knockout
Gtf2e2
protein/peptide accumulation
Microglial Cell Line
Gene: Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcript...
Does Knockout of Ddx56 in myoblast cell line causally result in protein/peptide distribution?
0
1,683
Knockout
Ddx56
protein/peptide distribution
myoblast cell line
Gene: Ddx56 (DEAD box helicase 56) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cytoplasmic pattern recognition receptor signaling pathway, defense response to virus, host-mediated perturbation of viral RNA genome replication, negative regulation of type I interferon p...
Does Knockout of Tmed1 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,152
Knockout
Tmed1
protein/peptide accumulation
Embryonic Cell Line
Gene: Tmed1 (transmembrane p24 trafficking protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport; CC: COPII-coated ER to Golgi transport ...
Does Knockout of Gstm2 in macrophage causally result in phagocytosis?
0
1,890
Knockout
Gstm2
phagocytosis
macrophage
Gene: Gstm2 (glutathione S-transferase, mu 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: glutathione metabolic process, hepoxilin biosynthetic process, lipid metabolic process, xenobiotic catabolic process; MF: enzyme binding, glutathione binding, glutathione transfe...
Does Knockout of Fbxl19 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,261
Knockout
Fbxl19
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Fbxl19 (F-box and leucine-rich repeat protein 19) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell migration, chromatin remodeling, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of transcription by RNA polymerase II; MF: DNA bindi...
Does Knockout of Srp68 in myoblast cell line causally result in protein/peptide distribution?
0
1,684
Knockout
Srp68
protein/peptide distribution
myoblast cell line
Gene: Srp68 (signal recognition particle 68) Type: protein-coding Summary: No summary available. Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, response to xenobiotic stimulus; MF: 7S RNA binding, RNA binding, endoplasmic reticulum signal peptide binding, protei...
Does Knockout of Luzp2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,259
Knockout
Luzp2
cell proliferation
Mouse kidney carcinoma cell
Gene: Luzp2 (leucine zipper protein 2) Type: protein-coding Summary: No summary available. Gene Ontology: CC: cellular_component, extracellular region Pathways: UniProt: Q8BGY3 Entrez ID: 233271
Does Knockout of Mesp2 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,399
Knockout
Mesp2
protein/peptide accumulation
Microglial Cell Line
Gene: Mesp2 (mesoderm posterior 2) Type: protein-coding Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Act...
Does Knockout of Tst in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Tst
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Tst (thiosulfate sulfurtransferase, mitochondrial) Type: protein-coding Summary: No summary available. Gene Ontology: BP: epithelial cell differentiation, rRNA import into mitochondrion, rRNA transport; MF: 3-mercaptopyruvate sulfurtransferase activity, 5S rRNA binding, RNA binding, sulfu...
Does Knockout of Krtap4-2 in macrophage causally result in phagocytosis?
0
1,890
Knockout
Krtap4-2
phagocytosis
macrophage
Gene: Krtap4-2 (keratin associated protein 4-2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: biological_process, hair cycle; CC: cellular_component, cytosol, intermediate filament, keratin filament Pathways: Developmental Biology, Keratinization UniPr...
Does Knockout of Nagk in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,274
Knockout
Nagk
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Nagk (N-acetylglucosamine kinase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: N-acetylglucosamine catabolic process, N-acetylglucosamine metabolic process, N-acetylneuraminate catabolic process, UDP-N-acetylglucosamine biosynthetic process, canonical NF-kappaB s...
Does Knockout of Sac3d1 in myoblast cell line causally result in protein/peptide distribution?
0
1,680
Knockout
Sac3d1
protein/peptide distribution
myoblast cell line
Gene: Sac3d1 (SAC3 domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell division, centrosome duplication, negative regulation of receptor signaling pathway via JAK-STAT, regulation of immune response, spindle assembly; CC: centrosome, cytoplasm, cytos...
Does Knockout of Rpl4 in macrophage causally result in phagocytosis?
0
1,890
Knockout
Rpl4
phagocytosis
macrophage
Gene: Rpl4 (ribosomal protein L4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: 5S rRNA binding, RNA binding, protein binding, structural constituent of ribosome; CC: A band...
Does Knockout of Ndc1 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,271
Knockout
Ndc1
cell proliferation
Mouse kidney carcinoma cell
Gene: Ndc1 (NDC1 transmembrane nucleoporin) Type: protein-coding Summary: Predicted to enable protein-macromolecule adaptor activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within homologous chromosome pairing at meiosis and spermatogenesis. Located in cytoplasm. P...
Does Knockout of Notch1 in breast epithelium causally result in cell cycle progression?
0
1,469
Knockout
Notch1
cell cycle progression
breast epithelium
Gene: Notch1 (notch 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Notch signaling pathway, Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation, T-helper 17 type immune response, angiogenesis, animal organ regeneration, ao...
Does Knockout of Naa10 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
81
Knockout
Naa10
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Naa10 (N(alpha)-acetyltransferase 10, NatA catalytic subunit) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric; MF: N-acetyltransferase activity, acetyltransferase activity, acyltran...
Does Knockout of Kcnmb3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
1,130
Knockout
Kcnmb3
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Kcnmb3 (potassium large conductance calcium-activated channel, subfamily M, beta member 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: action potential, detection of calcium ion, monoatomic ion transmembrane transport, monoatomic ion transport, neuronal action p...
Does Knockout of Prmt3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
167
Knockout
Prmt3
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Prmt3 (protein arginine N-methyltransferase 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: chromatin remodeling, dendritic spine morphogenesis, methylation, negative regulation of protein ubiquitination, negative regulation of retinoic acid biosynthetic process,...
Does Knockout of Srek1ip1 in Embryonic Stem Cell Line causally result in cell proliferation?
0
578
Knockout
Srek1ip1
cell proliferation
Embryonic Stem Cell Line
Gene: Srek1ip1 (splicing regulatory glutamine/lysine-rich protein 1interacting protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA splicing, biological_process, mRNA processing; MF: metal ion binding, molecular_function, nucleic acid binding, zinc ion binding ...
Does Knockout of Chrna3 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Chrna3
phagocytosis
macrophage
Gene: Chrna3 (cholinergic receptor, nicotinic, alpha polypeptide 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: acetylcholine receptor signaling pathway, behavioral response to nicotine, excitatory postsynaptic potential, locomotory behavior, membrane depolarization, ...
Does Knockout of Mdk in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,274
Knockout
Mdk
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Mdk (midkine) Type: protein-coding Summary: This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of se...
Does Knockout of Rtp1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
0
2,359
Knockout
Rtp1
response to chemicals
Pancreatic Cancer Cell Line
Gene: Rtp1 (receptor transporter protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: detection of chemical stimulus involved in sensory perception of bitter taste, protein insertion into membrane, protein targeting to membrane; MF: metal ion binding, olfactory rece...
Does Knockout of Prl2c1 in Microglial Cell Line causally result in response to virus?
0
1,439
Knockout
Prl2c1
response to virus
Microglial Cell Line
Gene: Prl2c1 (Prolactin family 2, subfamily c, member 1) Type: protein-coding Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of rec...
Does Knockout of Snhg11 in macrophage causally result in phagocytosis?
0
1,890
Knockout
Snhg11
phagocytosis
macrophage
Gene: Snhg11 (small nucleolar RNA host gene 11) Type: ncRNA Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID: 319317
Does Knockout of Adam1a in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Adam1a
protein/peptide accumulation
Embryonic Cell Line
Gene: Adam1a (a disintegrin and metallopeptidase domain 1a) Type: protein-coding Summary: No summary available. Gene Ontology: BP: binding of sperm to zona pellucida, fusion of sperm to egg plasma membrane involved in single fertilization, male gonad development, proteolysis; MF: hydrolase acti...
Does Knockout of Zfp583 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,398
Knockout
Zfp583
protein/peptide accumulation
Microglial Cell Line
Gene: Zfp583 (zinc finger protein 583) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA ...
Does Knockout of Nox4 in macrophage causally result in phagocytosis?
0
1,889
Knockout
Nox4
phagocytosis
macrophage
Gene: Nox4 (NADPH oxidase 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: bone resorption, cardiac muscle cell differentiation, cell morphogenesis, defense response, gene expression, heart process, homocysteine metabolic process, intracellular signal transduction, nega...
Does Knockout of Ralgapb in breast epithelium causally result in cell cycle progression?
0
1,470
Knockout
Ralgapb
cell cycle progression
breast epithelium
Gene: Ralgapb (Ral GTPase activating protein, beta subunit (non-catalytic)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Ral protein signal transduction, activation of GTPase activity, regulation of exocyst localization, regulation of protein localization, regulation o...
Does Knockout of Mbd4 in Lymphoma Cell Line causally result in response to chemicals?
0
1,553
Knockout
Mbd4
response to chemicals
Lymphoma Cell Line
Gene: Mbd4 (methyl-CpG binding domain protein 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, intrinsic apoptotic signaling pathway in response to DNA damage, mitotic G2 DNA damage checkpoint signaling, response to radiation; MF: DNA bi...
Does Knockout of Fignl2 in myoblast cell line causally result in protein/peptide distribution?
0
1,685
Knockout
Fignl2
protein/peptide distribution
myoblast cell line
Gene: Fignl2 (fidgetin-like 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: microtubule severing, morphogenesis of a branching structure, negative regulation of axon regeneration, negative regulation of cell migration, negative regulation of wound healing, spreading of...
Does Knockout of Kazald1 in myoblast cell line causally result in protein/peptide distribution?
0
1,684
Knockout
Kazald1
protein/peptide distribution
myoblast cell line
Gene: Kazald1 (Kazal-type serine peptidase inhibitor domain 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, extracellular matrix organization, ossification, regulation of cell growth, regulation of signal transduction; CC: extracellular matrix, ex...
Does Knockout of Dmc1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,274
Knockout
Dmc1
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Dmc1 (DNA meiotic recombinase 1) Type: protein-coding Summary: This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionari...
Does Knockout of Plec in Melanoma Cell Line causally result in cell proliferation?
0
1,281
Knockout
Plec
cell proliferation
Melanoma Cell Line
Gene: Plec (plectin) Type: protein-coding Summary: Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain stru...
Does Knockout of Nup188 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,399
Knockout
Nup188
protein/peptide accumulation
Microglial Cell Line
Gene: Nup188 (nucleoporin 188) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein import into nucleus, protein transport; MF: structural constituent of nuclear pore; CC: nuclear envelope, nuclear p...
Does Knockout of Brd3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,175
Knockout
Brd3
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Brd3 (bromodomain containing 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: chromatin organization, chromatin remodeling, endodermal cell differentiation, positive regulation of transcription by RNA polymerase II, protein localization to chromatin, regulation of...
Does Knockout of Tex30 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
0
1,077
Knockout
Tex30
protein/peptide accumulation
Mouse Embryonic Stem Cell
Gene: Tex30 (testis expressed 30) Type: protein-coding Summary: Is expressed in diencephalon lateral wall ventricular layer; midbrain ventricular layer; and telencephalon ventricular layer. Orthologous to human TEX30 (testis expressed 30). [provided by Alliance of Genome Resources, Jul 2025] Ge...
Does Knockout of Dnm1 in Melanoma Cell Line causally result in cell proliferation?
0
2,492
Knockout
Dnm1
cell proliferation
Melanoma Cell Line
Gene: Dnm1 (dynamin 1) Type: protein-coding Summary: This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via associatio...
Does Knockout of Ddrgk1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
83
Knockout
Ddrgk1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Ddrgk1 (DDRGK domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cartilage development, negative regulation of IRE1-mediated unfolded protein response, negative regulation of PERK-mediated unfolded protein response, negative regulation of apoptotic...
Does Knockout of Cmtm3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
82
Knockout
Cmtm3
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Cmtm3 (CKLF-like MARVEL transmembrane domain containing 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: blastocyst hatching, chemotaxis, positive regulation of B cell receptor signaling pathway, signal transduction; MF: cytokine activity, protein binding; CC: cyt...
Does Knockout of Slc22a19 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,399
Knockout
Slc22a19
protein/peptide accumulation
Microglial Cell Line
Gene: Slc22a19 (solute carrier family 22 (organic anion transporter), member 19) Type: protein-coding Summary: No summary available. Gene Ontology: BP: monoatomic ion transport, organic anion transport, response to molecule of fungal origin, transmembrane transport; MF: organic anion transmembr...
Does Knockout of Sprr3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
687
Knockout
Sprr3
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Sprr3 (small proline-rich protein 3) Type: protein-coding Summary: No summary available. Gene Ontology: CC: Golgi apparatus, cytoplasm, perinuclear region of cytoplasm Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization UniProt: O09116 ...
Does Knockout of Mfsd9 in Microglial Cell Line causally result in response to virus?
0
1,439
Knockout
Mfsd9
response to virus
Microglial Cell Line
Gene: Mfsd9 (major facilitator superfamily domain containing 9) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: Q8C0T7 Entrez ID: 211798
Does Knockout of Gm13290 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
Gm13290
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Gm13290 (predicted gene 13290) Type: protein-coding Summary: predicted gene 13290 Gene Ontology: Pathways: UniProt: Q8CD73 Entrez ID: 545646
Does Knockout of Fut1 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,263
Knockout
Fut1
cell proliferation
Colonic Cancer Cell Line
Gene: Fut1 (fucosyltransferase 1) Type: protein-coding Summary: This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus a...
Does Knockout of Cmbl in Melanoma Cell Line causally result in cell proliferation?
0
1,282
Knockout
Cmbl
cell proliferation
Melanoma Cell Line
Gene: Cmbl (carboxymethylenebutenolidase homolog) Type: protein-coding Summary: No summary available. Gene Ontology: MF: hydrolase activity, molecular_function; CC: cytoplasm, cytosol Pathways: Biological oxidations, Metabolism, Phase I - Functionalization of compounds UniProt...
Does Knockout of Slc25a28 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
1
345
Knockout
Slc25a28
cell proliferation
Embryonic Fibroblast Cell Line
Gene: Slc25a28 (solute carrier family 25, member 28) Type: protein-coding Summary: No summary available. Gene Ontology: BP: iron import into the mitochondrion, iron ion transport, monoatomic ion transport; MF: ferrous iron transmembrane transporter activity; CC: membrane, mitochondrial inner me...