prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Cdadc1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Cdadc1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cdadc1 (cytidine and dCMP deaminase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: catalytic activity, cytidine deaminase activity, dCMP deaminase activity, hydrolase activity, importin-alpha family protein binding, metal ion binding, protein homodimerization activity, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8BMD5
Entrez ID: 71891
|
Does Knockout of Stard6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Stard6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Stard6 (StAR related lipid transfer domain containing 6)
Type: protein-coding
Summary: Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Orthologous to human STARD6 (StAR related lipid transfer domain containing 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, lipid transport; MF: cholesterol binding, lipid binding
Pathways: Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Pregnenolone biosynthesis
UniProt: P59096
Entrez ID: 170461
|
Does Knockout of Pip4k2c in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Pip4k2c
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pip4k2c (phosphatidylinositol-5-phosphate 4-kinase, type II, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process, autophagosome-lysosome fusion, lipid metabolic process, negative regulation of insulin receptor signaling pathway, phosphatidylinositol metabolic process, phosphatidylinositol phosphate biosynthetic process, positive regulation of autophagosome assembly, regulation of autophagy; MF: 1-phosphatidylinositol-4-phosphate 5-kinase activity, 1-phosphatidylinositol-5-phosphate 4-kinase activity, ATP binding, identical protein binding, kinase activity, nucleotide binding, phosphatidylinositol kinase activity, transferase activity; CC: autophagosome, cytoplasm, cytosol, endoplasmic reticulum, nucleoplasm, plasma membrane
Pathways: D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, Gene expression (Transcription), Generic Transcription Pathway, Inositol phosphate metabolism - Mus musculus (mouse), Intracellular signaling by second messengers, Metabolism, Metabolism of lipids, Negative regulation of the PI3K/AKT network, PI Metabolism, PI5P Regulates TP53 Acetylation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP metabolism, PIP3 activates AKT signaling, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Synthesis of PIPs at the plasma membrane, Synthesis of PIPs in the nucleus, Transcriptional Regulation by TP53
UniProt: Q91XU3
Entrez ID: 117150
|
Does Knockout of Pla2g4d in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Pla2g4d
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pla2g4d (phospholipase A2, group IVD)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, glycerophospholipid catabolic process, lipid catabolic process, lipid metabolic process, phospholipid catabolic process; MF: calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding, hydrolase activity, metal ion binding, phospholipase A2 activity, phospholipase activity; CC: cytoplasm, cytosol, membrane
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PG, Acyl chain remodelling of PI, Acyl chain remodelling of PS, Arachidonic acid metabolism - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Ether lipid metabolism - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Hydrolysis of LPC, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of lipids, Necroptosis - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Platelet activation - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Synthesis of PA, VEGF signaling pathway - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), phospholipases
UniProt: Q50L43
Entrez ID: 78390
|
Does Knockout of Abcc5 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Abcc5
|
cell proliferation
|
Regulatory T cell
|
Gene: Abcc5 (ATP-binding cassette, sub-family C member 5)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cAMP transport, cGMP transport, export across plasma membrane, folate transmembrane transport, glutathione transmembrane transport, heme transmembrane transport, hyaluronan biosynthetic process, purine nucleotide transport, transmembrane transport, xenobiotic transport; MF: ABC-type transporter activity, ABC-type xenobiotic transporter activity, ATP binding, ATP hydrolysis activity, carbohydrate derivative transmembrane transporter activity, efflux transmembrane transporter activity, glutathione transmembrane transporter activity, heme transmembrane transporter activity, macromolecule transmembrane transporter activity, nucleotide binding, purine nucleotide transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: Golgi apparatus, Golgi lumen, apical plasma membrane, basolateral plasma membrane, endosome, endosome membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC-family proteins mediated transport, Azathioprine ADME, Drug ADME, Glycosaminoglycan metabolism, Hyaluronan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Paracetamol ADME, Transport of small molecules
UniProt: Q9R1X5
Entrez ID: 27416
|
Does Knockout of Bin2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Bin2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Bin2 (bridging integrator 2)
Type: protein-coding
Summary: Predicted to enable phospholipid binding activity. Predicted to be involved in several processes, including phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Predicted to be located in anchoring junction; cell cortex; and cell projection. Predicted to be active in plasma membrane and podosome. Predicted to colocalize with phagocytic cup. Is expressed in liver and thymus primordium. Orthologous to human BIN2 (bridging integrator 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell chemotaxis, phagocytosis, engulfment, plasma membrane tubulation, podosome assembly; MF: phospholipid binding; CC: anchoring junction, cell cortex, cell projection, cytoplasm, membrane, phagocytic cup, plasma membrane, podosome
Pathways:
UniProt: S4R1B8, S4R270, S4R171, S4R2J8, A0A5F8MQ05, S4R1Q1
Entrez ID: 668218
|
Does Knockout of Stxbp4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Stxbp4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Stxbp4 (syntaxin binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cellular response to type II interferon, insulin receptor signaling pathway, positive regulation of cell cycle G1/S phase transition, positive regulation of keratinocyte proliferation, protein stabilization, protein targeting, regulation of D-glucose transmembrane transport, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of transport, response to stress; MF: protein binding, syntaxin binding; CC: cytoplasm, cytoplasmic vesicle, phagocytic vesicle
Pathways:
UniProt: Q9WV89
Entrez ID: 20913
|
Does Knockout of Gm6811 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Gm6811
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm6811 (sperm motility kinase Y pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 627924
|
Does Knockout of Ptges in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Ptges
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ptges (prostaglandin E synthase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular oxidant detoxification, cyclooxygenase pathway, fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, negative regulation of cell population proliferation, positive regulation of prostaglandin secretion, prostaglandin biosynthetic process, prostaglandin metabolic process, regulation of fever generation, regulation of inflammatory response, sensory perception of pain; MF: glutathione binding, glutathione peroxidase activity, glutathione transferase activity, isomerase activity, oxidoreductase activity, prostaglandin-D synthase activity, prostaglandin-E synthase activity, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum membrane, membrane, nuclear envelope lumen, perinuclear region of cytoplasm
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Synthesis of Prostaglandins (PG) and Thromboxanes (TX), biosynthesis of prostaglandins
UniProt: Q9JM51
Entrez ID: 64292
|
Does Knockout of Slc1a7 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Slc1a7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc1a7 (solute carrier family 1 (glutamate transporter), member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate transmembrane transport, chloride transmembrane transport, excitatory postsynaptic potential, monoatomic anion transmembrane transport, neurotransmitter uptake, neutral amino acid transport; MF: L-glutamate transmembrane transporter activity, extracellularly glutamate-gated chloride channel activity, glutamate:sodium symporter activity, monoatomic anion transmembrane transporter activity, neutral L-amino acid transmembrane transporter activity, symporter activity; CC: axon terminus, glutamatergic synapse, membrane, photoreceptor cell terminal bouton, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse, synaptic membrane
Pathways: Glutamate Neurotransmitter Release Cycle, Glutamatergic synapse - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules
UniProt: Q8JZR4
Entrez ID: 242607
|
Does Knockout of Tmed3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Tmed3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tmed3 (transmembrane p24 trafficking protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport; CC: COPI vesicle coat, COPI-coated vesicle membrane, COPII-coated ER to Golgi transport vesicle, Golgi apparatus, Golgi cisterna membrane, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q78IS1
Entrez ID: 66111
|
Does Knockout of P2ry13 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
P2ry13
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: P2ry13 (purinergic receptor P2Y, G-protein coupled 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled purinergic nucleotide receptor signaling pathway, G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled purinergic nucleotide receptor activity, G protein-coupled receptor activity; CC: endoplasmic reticulum, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nucleotide-like (purinergic) receptors, P2Y receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9D8I2
Entrez ID: 74191
|
Does Knockout of Gm1604b in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Gm1604b
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Gm1604b (predicted gene 1604b)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3TRG0
Entrez ID: 381059
|
Does Knockout of Dolpp1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Dolpp1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Dolpp1 (dolichyl pyrophosphate phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein N-linked glycosylation, protein glycosylation; MF: dolichyldiphosphatase activity, hydrolase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Synthesis of dolichyl-phosphate, Synthesis of substrates in N-glycan biosythesis
UniProt: Q9JMF7
Entrez ID: 57170
|
Does Knockout of Rnf220 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Rnf220
|
response to virus
|
Microglial Cell Line
|
Gene: Rnf220 (ring finger protein 220)
Type: protein-coding
Summary: Enables ubiquitin protein ligase activity. Involved in protein autoubiquitination and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within nervous system development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Located in cytoplasm. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and tooth. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: dorsal/ventral neural tube patterning, noradrenergic neuron development, positive regulation of canonical Wnt signaling pathway, protein autoubiquitination, protein monoubiquitination, protein ubiquitination, regulation of postsynaptic neurotransmitter receptor internalization; MF: beta-catenin binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, glutamatergic synapse, nuclear lamina, nucleoplasm, nucleus, postsynapse, protein-containing complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q6PDX6
Entrez ID: 66743
|
Does Knockout of Tll1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Tll1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tll1 (tolloid-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, dorsal/ventral pattern formation, protein processing, proteolysis; MF: calcium ion binding, collagen binding, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular region, extracellular space
Pathways:
UniProt: A0A1B0GRW8, G3X9F5
Entrez ID: 21892
|
Does Knockout of Cd3e in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Cd3e
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cd3e (CD3 antigen, epsilon polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell costimulation, T cell receptor signaling pathway, adaptive immune response, apoptotic signaling pathway, cell surface receptor signaling pathway, cerebellum development, dendrite development, immune system process, lymphocyte activation, negative regulation of gene expression, negative regulation of smoothened signaling pathway, negative thymic T cell selection, positive regulation of CD4-positive, alpha-beta T cell proliferation, positive regulation of MAPK cascade, positive regulation of T cell activation, positive regulation of T cell anergy, positive regulation of T cell proliferation, positive regulation of calcium-mediated signaling, positive regulation of cell-cell adhesion mediated by integrin, positive regulation of cell-matrix adhesion, positive regulation of gene expression, positive regulation of interleukin-2 production, positive regulation of interleukin-4 production, positive regulation of type II interferon production, positive thymic T cell selection, regulation of signal transduction, response to nutrient; MF: SH3 domain binding, identical protein binding, protein binding, transmembrane signaling receptor activity; CC: Golgi apparatus, T cell receptor complex, alpha-beta T cell receptor complex, cell body, cell-cell junction, dendritic spine, endoplasmic reticulum, external side of plasma membrane, immunological synapse, membrane, plasma membrane
Pathways: Adaptive Immune System, Chagas disease - Mus musculus (mouse), Co-inhibition by PD-1, Downstream TCR signaling, Epstein-Barr virus infection - Mus musculus (mouse), Generation of second messenger molecules, Hematopoietic cell lineage - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Measles - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Phosphorylation of CD3 and TCR zeta chains, Primary immunodeficiency - Mus musculus (mouse), Regulation of T cell activation by CD28 family, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Translocation of ZAP-70 to Immunological synapse
UniProt: P22646
Entrez ID: 12501
|
Does Knockout of Cacna2d1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Cacna2d1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cacna2d1 (calcium channel, voltage-dependent, alpha2/delta subunit 1)
Type: protein-coding
Summary: This gene encodes a regulatory component of the voltage-dependent calcium channel complex. The product of this gene is a proprotein that is proteolytically processed into alpha-2 and delta subunits, which are linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transmembrane transport via high voltage-gated calcium channel, calcium ion transport, calcium ion transport into cytosol, cardiac muscle cell action potential involved in contraction, cellular response to amyloid-beta, membrane depolarization during bundle of His cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of calcium ion transport, regulation of heart rate by cardiac conduction, regulation of membrane repolarization during action potential, regulation of ventricular cardiac muscle cell membrane repolarization; MF: calcium channel activity, metal ion binding, protein binding, voltage-gated calcium channel activity, voltage-gated calcium channel activity involved in bundle of His cell action potential; CC: GABA-ergic synapse, L-type voltage-gated calcium channel complex, T-tubule, glutamatergic synapse, membrane, monoatomic ion channel complex, neuronal dense core vesicle, plasma membrane, postsynaptic membrane, presynaptic active zone membrane, sarcoplasmic reticulum, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse)
UniProt: O08532
Entrez ID: 12293
|
Does Knockout of Wnk1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Wnk1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Wnk1 (WNK lysine deficient protein kinase 1)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular chloride ion homeostasis; and lymphocyte migration into lymph node. Acts upstream of or within several processes, including negative regulation of pancreatic juice secretion; negative regulation of small GTPase mediated signal transduction; and protein phosphorylation. Part of protein-containing complex. Is active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: T cell receptor signaling pathway, cell volume homeostasis, cellular hyperosmotic response, cellular response to calcium ion, cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, heart development, intracellular chloride ion homeostasis, intracellular signal transduction, lymphocyte migration into lymph node, membraneless organelle assembly, modulation of chemical synaptic transmission, monoatomic cation homeostasis, monoatomic ion homeostasis, monoatomic ion transport, negative regulation of autophagy, negative regulation of cell-cell adhesion mediated by integrin, negative regulation of heterotypic cell-cell adhesion, negative regulation of leukocyte cell-cell adhesion, negative regulation of pancreatic juice secretion, negative regulation of protein localization to plasma membrane, negative regulation of protein ubiquitination, negative regulation of small GTPase mediated signal transduction, negative regulation of sodium ion transport, positive regulation of T cell chemotaxis, positive regulation of angiogenesis, positive regulation of canonical Wnt signaling pathway, positive regulation of mitotic cytokinesis, positive regulation of potassium ion import across plasma membrane, positive regulation of systemic arterial blood pressure, positive regulation of termination of RNA polymerase II transcription, potassium ion homeostasis, potassium ion transmembrane transport, protein insertion into ER membrane by stop-transfer membrane-anchor sequence, regulation of blood pressure, regulation of mRNA export from nucleus, regulation of monoatomic cation transmembrane transport, regulation of sodium ion transmembrane transport, regulation of sodium ion transport, signal transduction, sodium ion transmembrane transport; MF: ATP binding, kinase activity, magnesium ion binding, molecular condensate scaffold activity, nucleotide binding, phosphatase binding, potassium channel inhibitor activity, protein binding, protein kinase activator activity, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine kinase inhibitor activity, transferase activity; CC: GABA-ergic synapse, cytoplasm, cytoskeleton, cytosol, intracellular membraneless organelle, membrane, mitotic spindle, nucleus, protein-containing complex, spindle
Pathways:
UniProt: P83741
Entrez ID: 232341
|
Does Knockout of Padi1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Padi1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Padi1 (peptidyl arginine deiminase, type I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, hydrolase activity, metal ion binding, protein-arginine deiminase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, protein citrullination
UniProt: Q9Z185
Entrez ID: 18599
|
Does Knockout of Pdha1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Pdha1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pdha1 (pyruvate dehydrogenase E1 alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucose metabolic process, pyruvate decarboxylation to acetyl-CoA, tricarboxylic acid cycle; MF: metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, protein binding, pyruvate dehydrogenase (acetyl-transferring) activity; CC: mitochondrial matrix, mitochondrion, myelin sheath, nucleolus, oxidoreductase complex, pyruvate dehydrogenase complex
Pathways: Aerobic respiration and respiratory electron transport, Central carbon metabolism in cancer - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, PDH complex synthesizes acetyl-CoA from PYR, Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), Regulation of pyruvate dehydrogenase (PDH) complex, Regulation of pyruvate metabolism, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, acetyl-CoA biosynthesis (from pyruvate), superpathway of acetyl-CoA biosynthesis
UniProt: P35486
Entrez ID: 18597
|
Does Knockout of Man2c1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Man2c1
|
cell proliferation
|
Regulatory T cell
|
Gene: Man2c1 (mannosidase, alpha, class 2C, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, mannose metabolic process, oligosaccharide catabolic process; MF: alpha-mannosidase activity, carbohydrate binding, catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, metal ion binding; CC: cytoplasm, nucleoplasm
Pathways: Lysosomal oligosaccharide catabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Other glycan degradation - Mus musculus (mouse)
UniProt: Q91W89
Entrez ID: 73744
|
Does Knockout of Prol1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Prol1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Prol1 (proline rich, lacrimal 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: E9PYQ4
Entrez ID: 17830
|
Does Knockout of Dus4l in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Dus4l
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Dus4l (dihydrouridine synthase 4 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA dihydrouridine synthesis, tRNA processing; MF: flavin adenine dinucleotide binding, oxidoreductase activity, tRNA dihydrouridine synthase activity, tRNA-dihydrouridine20a synthase activity, tRNA-dihydrouridine20b synthase activity
Pathways:
UniProt: Q32M08
Entrez ID: 71916
|
Does Knockout of Ypel1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Ypel1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ypel1 (yippee like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: Q9ESC7
Entrez ID: 106369
|
Does Knockout of Phox2b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Phox2b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Phox2b (paired-like homeobox 2b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autonomic nervous system development, brainstem development, cell development, cell differentiation in hindbrain, cellular response to BMP stimulus, cellular response to carbon dioxide, dopaminergic neuron differentiation, efferent axon development in a lateral line nerve, enteric nervous system development, glial cell differentiation, hindbrain tangential cell migration, inner ear development, medullary reticular formation development, membrane depolarization, motor neuron migration, negative regulation of neuron differentiation, negative regulation of type B pancreatic cell proliferation, neural crest cell migration involved in autonomic nervous system development, neural nucleus development, neuron development, neuron differentiation, noradrenergic neuron development, noradrenergic neuron differentiation, parasympathetic nervous system development, positive regulation of cold-induced thermogenesis, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression, regulation of respiratory gaseous exchange, regulation of respiratory gaseous exchange by nervous system process, regulation of transcription by RNA polymerase II, respiratory system development, response to activity, retrotrapezoid nucleus neuron differentiation, skeletal muscle cell differentiation, sympathetic ganglion development, sympathetic nervous system development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways:
UniProt: O35690
Entrez ID: 18935
|
Does Knockout of Samd7 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Samd7
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Samd7 (sterile alpha motif domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, retinal rod cell development; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, chromatin binding, histone binding, protein binding; CC: PRC1 complex, cytoplasm, nucleus
Pathways:
UniProt: Q8C8Y5
Entrez ID: 75953
|
Does Knockout of Acsl4 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Acsl4
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Acsl4 (acyl-CoA synthetase long-chain family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-linolenic acid metabolic process, dendritic spine development, embryonic process involved in female pregnancy, fatty acid derivative biosynthetic process, fatty acid metabolic process, fatty acid transport, lipid biosynthetic process, lipid metabolic process, long-chain fatty acid biosynthetic process, long-chain fatty acid metabolic process, long-chain fatty-acyl-CoA biosynthetic process, long-chain fatty-acyl-CoA metabolic process, negative regulation of prostaglandin secretion, neuron differentiation, positive regulation of cell growth, positive regulation of ferroptosis, positive regulation of insulin secretion, regulation of fatty acid metabolic process, small molecule metabolic process, triglyceride biosynthetic process, unsaturated fatty acid biosynthetic process; MF: ATP binding, arachidonate-CoA ligase activity, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, very long-chain fatty acid-CoA ligase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, neuronal cell body, peroxisomal membrane, peroxisome, plasma membrane
Pathways: Adipocytokine signaling pathway - Mus musculus (mouse), Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Ferroptosis - Mus musculus (mouse), Free fatty acids regulate insulin secretion, Integration of energy metabolism, Intracellular metabolism of fatty acids regulates insulin secretion, Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), Peroxisome - Mus musculus (mouse), Regulation of insulin secretion, Synthesis of very long-chain fatty acyl-CoAs, Thermogenesis - Mus musculus (mouse), fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway), fatty acid activation
UniProt: Q9QUJ7
Entrez ID: 50790
|
Does Knockout of Bet1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Bet1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Bet1 (Bet1 golgi vesicular membrane trafficking protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, syntaxin binding; CC: Golgi apparatus, Golgi cis cisterna, Golgi cisterna, Golgi membrane, SNARE complex, cis-Golgi network, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O35623
Entrez ID: 12068
|
Does Knockout of Itpr3 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Itpr3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Itpr3 (inositol 1,4,5-triphosphate receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium ion homeostasis, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cellular response to cAMP, long-term synaptic potentiation, memory, monoatomic ion transmembrane transport, monoatomic ion transport, platelet activation, positive regulation of cytosolic calcium ion concentration, protein homotetramerization, release of sequestered calcium ion into cytosol, response to calcium ion, sensory perception of bitter taste, sensory perception of sweet taste, sensory perception of umami taste, transmembrane transport; MF: ATP binding, calcium channel activity, calcium ion binding, identical protein binding, inositol 1,3,4,5 tetrakisphosphate binding, inositol 1,4,5 trisphosphate binding, inositol 1,4,5-trisphosphate-gated calcium channel activity, inositol hexakisphosphate binding, intracellularly gated calcium channel activity, metal ion binding, monoatomic ion channel activity, nucleotide binding, phosphatidylinositol binding, protein binding, protein-containing complex binding, zinc ion binding; CC: apical part of cell, apical plasma membrane, brush border, cytoplasm, cytoplasmic side of endoplasmic reticulum membrane, cytoplasmic vesicle, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, neuronal cell body, nuclear envelope, nuclear outer membrane, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, presynapse, receptor complex, sarcoplasmic reticulum, secretory granule membrane, transport vesicle membrane
Pathways: Adaptive Immune System, Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Apelin signaling pathway - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cellular senescence - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Effects of PIP2 hydrolysis, Elevation of cytosolic Ca2+ levels, Estrogen signaling pathway - Mus musculus (mouse), G alpha (q) signalling events, GPCR downstream signalling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glutamatergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Ion homeostasis, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Metabolism, Muscle contraction, NOD-like receptor signaling pathway - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet calcium homeostasis, Platelet homeostasis, Prion disease - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of insulin secretion, Renin secretion - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Taste transduction - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P70227
Entrez ID: 16440
|
Does Knockout of Plxdc2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Plxdc2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Plxdc2 (plexin domain containing 2)
Type: protein-coding
Summary: Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; inner ear; limb; skin; and trunk mesenchyme. Orthologous to human PLXDC2 (plexin domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: CC: extracellular matrix, membrane, plasma membrane
Pathways:
UniProt: Q9DC11
Entrez ID: 67448
|
Does Knockout of Acox1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Acox1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Acox1 (acyl-Coenzyme A oxidase 1, palmitoyl)
Type: protein-coding
Summary: This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: alpha-linolenic acid metabolic process, cholesterol homeostasis, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA oxidase, fatty acid catabolic process, fatty acid derivative biosynthetic process, fatty acid metabolic process, fatty acid oxidation, generation of precursor metabolites and energy, hydrogen peroxide biosynthetic process, lipid homeostasis, lipid metabolic process, long-chain fatty acid biosynthetic process, peroxisome fission, prostaglandin metabolic process, spermatogenesis, unsaturated fatty acid biosynthetic process, very long-chain fatty acid beta-oxidation, very long-chain fatty acid metabolic process; MF: FAD binding, PDZ domain binding, acyl-CoA oxidase activity, fatty acid binding, flavin adenine dinucleotide binding, long-chain fatty acyl-CoA oxidase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, protein homodimerization activity; CC: cytoplasm, cytosol, mitochondrion, peroxisomal matrix, peroxisomal membrane, peroxisome
Pathways: Alcoholic liver disease - Mus musculus (mouse), Beta-oxidation of very long chain fatty acids, Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), Peroxisomal lipid metabolism, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Propanoate metabolism - Mus musculus (mouse), Protein localization, alpha-Linolenic acid metabolism - Mus musculus (mouse), alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism, beta-Alanine metabolism - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q9R0H0
Entrez ID: 11430
|
Does Knockout of Actl11 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Actl11
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Actl11 (actin-like 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: actin cytoskeleton, cytoskeleton
Pathways:
UniProt: Q9D5V1
Entrez ID: 67722
|
Does Knockout of Timm10 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Timm10
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Timm10 (translocase of inner mitochondrial membrane 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein transport; MF: membrane insertase activity, metal ion binding, protein homodimerization activity, protein-folding chaperone binding; CC: TIM22 mitochondrial import inner membrane insertion complex, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial intermembrane space chaperone complex, mitochondrion
Pathways:
UniProt: P62073
Entrez ID: 30059
|
Does Knockout of Utf1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,570
|
Knockout
|
Utf1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Utf1 (undifferentiated embryonic cell transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II; MF: HMG box domain binding, TBP-class protein binding, protein binding, transcription coactivator activity; CC: nucleus
Pathways:
UniProt: Q6J1H4
Entrez ID: 22286
|
Does Knockout of Car13 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Car13
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Car13 (carbonic anhydrase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbonate dehydratase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytoplasm, cytosol, myelin sheath
Pathways: Metabolism, Nitrogen metabolism - Mus musculus (mouse), Reversible hydration of carbon dioxide
UniProt: Q9D6N1
Entrez ID: 71934
|
Does Knockout of Pcdhga4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Pcdhga4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pcdhga4 (protocadherin gamma subfamily A, 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q91XY4
Entrez ID: 93712
|
Does Knockout of Eif4a3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Eif4a3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Eif4a3 (eukaryotic translation initiation factor 4A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, embryonic cranial skeleton morphogenesis, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, negative regulation of excitatory postsynaptic potential, negative regulation of gene expression, negative regulation of selenocysteine incorporation, negative regulation of translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of mRNA splicing, via spliceosome, positive regulation of transcription by RNA polymerase II, positive regulation of translation, rRNA processing, regulation of alternative mRNA splicing, via spliceosome, regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translation, regulation of translation at postsynapse, modulating synaptic transmission; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA stem-loop binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, poly(A) binding, ribonucleoprotein complex binding, selenocysteine insertion sequence binding; CC: U2-type catalytic step 1 spliceosome, catalytic step 2 spliceosome, cytoplasm, dendrite, exon-exon junction complex, glutamatergic synapse, neuronal cell body, nuclear speck, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), ISG15 antiviral mechanism, Immune System, Interferon Signaling, Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q91VC3
Entrez ID: 192170
|
Does Knockout of Vmp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Vmp1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmp1 (vacuole membrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, autophagosome assembly, autophagosome membrane docking, autophagy, cell adhesion, cell junction assembly, cell-cell adhesion, embryo implantation, lipid transport, lipoprotein transport, mitochondrion-endoplasmic reticulum membrane tethering, organelle localization by membrane tethering, plasma membrane phospholipid scrambling, positive regulation of ATPase-coupled calcium transmembrane transporter activity; MF: phospholipid scramblase activity; CC: autophagosome membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, nucleolus, phagophore assembly site, plasma membrane, vacuolar membrane, vacuole
Pathways: Autophagy - animal - Mus musculus (mouse)
UniProt: Q99KU0
Entrez ID: 75909
|
Does Knockout of Gna15 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Gna15
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gna15 (guanine nucleotide binding protein, alpha 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, action potential, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, calcium-mediated signaling, phospholipase C-activating G protein-coupled receptor signaling pathway, phospholipase C-activating dopamine receptor signaling pathway, signal transduction; MF: G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, guanyl nucleotide binding, metal ion binding, nucleotide binding; CC: cytoplasm, heterotrimeric G-protein complex
Pathways: ADP signalling through P2Y purinoceptor 1, Acetylcholine regulates insulin secretion, Amoebiasis - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Free fatty acids regulate insulin secretion, G alpha (i) signalling events, G alpha (q) signalling events, G-protein activation, G-protein mediated events, GPCR downstream signalling, Hemostasis, Integration of energy metabolism, Metabolism, Metabolism of proteins, Opioid Signalling, PLC beta mediated events, Platelet activation, signaling and aggregation, Protein folding, Regulation of insulin secretion, Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signal amplification, Signaling by GPCR, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, cyclic AMP biosynthesis
UniProt: P30678
Entrez ID: 14676
|
Does Knockout of Slc39a10 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Slc39a10
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Slc39a10 (solute carrier family 39 (zinc transporter), member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, epithelial to mesenchymal transition, intracellular monoatomic cation homeostasis, intracellular zinc ion homeostasis, metal ion transport, monoatomic ion transport, negative regulation of B cell apoptotic process, positive regulation of B cell proliferation, positive regulation of B cell receptor signaling pathway, transmembrane transport, zinc ion import across plasma membrane, zinc ion transmembrane transport, zinc ion transport; MF: metal ion transmembrane transporter activity, monoatomic cation:bicarbonate symporter activity, protein binding, protein tyrosine phosphatase activator activity, zinc ion transmembrane transporter activity; CC: apical plasma membrane, membrane, plasma membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse)
UniProt: Q6P5F6
Entrez ID: 227059
|
Does Knockout of Exoc5 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Exoc5
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Exoc5 (exocyst complex component 5)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Involved in protein localization to plasma membrane. Acts upstream of or within with a positive effect on establishment of planar polarity. Acts upstream of or within with a negative effect on epithelial cell apoptotic process. Acts upstream of or within homeostasis of number of cells within a tissue; morphogenesis of a polarized epithelium; and non-motile cilium assembly. Predicted to be located in cytosol. Predicted to be part of exocyst. Is expressed in 1-cell stage embryo; cerebral cortex ventricular layer; cortical plate; primary oocyte; and secondary oocyte. Used to study obstructive nephropathy. Orthologous to human EXOC5 (exocyst complex component 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi to plasma membrane transport, epithelial cell apoptotic process, establishment of planar polarity, exocytosis, homeostasis of number of cells within a tissue, membrane fission, mitotic cytokinesis, morphogenesis of a polarized epithelium, non-motile cilium assembly, protein localization to plasma membrane, protein transport, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; MF: protein binding, small GTPase binding; CC: cytoplasm, cytosol, exocyst, midbody
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Insulin processing, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, Salmonella infection - Mus musculus (mouse), VxPx cargo-targeting to cilium
UniProt: Q3TPX4
Entrez ID: 105504
|
Does Knockout of Tsc22d4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Tsc22d4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tsc22d4 (Tsc22 domain family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucose homeostasis, negative regulation of transcription by RNA polymerase II, neuron cellular homeostasis, neuron projection extension, regulation of transcription by RNA polymerase II; CC: cell projection, cytoplasm, dendrite, nucleus, synapse
Pathways:
UniProt: Q9EQN3
Entrez ID: 78829
|
Does Knockout of Sgsm1 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Sgsm1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Sgsm1 (small G protein signaling modulator 1)
Type: protein-coding
Summary: Enables small GTPase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle membrane. Is expressed in several structures, including brain and metanephros. Orthologous to human SGSM1 (small G protein signaling modulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: GTPase activator activity, protein binding, small GTPase binding; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, membrane
Pathways:
UniProt: Q8BPQ7
Entrez ID: 52850
|
Does Knockout of Pomt2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Pomt2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pomt2 (protein-O-mannosyltransferase 2)
Type: protein-coding
Summary: This gene encodes an integral membrane protein that belongs to the dolichyl-phosphate-mannose-protein mannosyltransferase family. The encoded enzyme is found in the membrane of the endoplasmic reticulum. This protein is a component of the protein O-mannosyltransferase enzyme complex which is involved in modification of the protein alpha-dystroglycan. Mutations in the human gene are a cause of different forms of muscular dystrophy-dystroglycanopathy (MDDG), type A2 (also known as Walker-Warburg syndrome), type B2 and type C2 (also known as limb-girdle muscular dystrophy). [provided by RefSeq, Sep 2015].
Gene Ontology: BP: basement membrane organization, dentate gyrus development, protein O-linked glycosylation, protein O-linked glycosylation via mannose, protein glycosylation, reactive gliosis; MF: dolichyl-phosphate-mannose-protein mannosyltransferase activity, glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: cytosol, dolichyl-phosphate-mannose-protein mannosyltransferase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus, nucleoplasm
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, DAG1 core M1 glycosylations, DAG1 core M2 glycosylations, DAG1 core M3 glycosylations, DAG1 glycosylations, Mannose type O-glycan biosynthesis - Mus musculus (mouse), Metabolism of proteins, O-linked glycosylation, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q8BGQ4
Entrez ID: 217734
|
Does Knockout of Zfp672 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Zfp672
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp672 (zinc finger protein 672)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q99LH4
Entrez ID: 319475
|
Does Knockout of Dtx4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Dtx4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dtx4 (deltex 4, E3 ubiquitin ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, antiviral innate immune response, innate immune response, negative regulation of innate immune response, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein ubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: centrosome, cytoplasm, nucleoplasm
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Cytosolic sensors of pathogen-associated DNA , IRF3-mediated induction of type I IFN, Immune System, Innate Immune System, Notch signaling pathway - Mus musculus (mouse), Regulation of innate immune responses to cytosolic DNA, STING mediated induction of host immune responses, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1
UniProt: Q6PDK8
Entrez ID: 207521
|
Does Knockout of Exosc1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Exosc1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Exosc1 (exosome component 1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in RNA catabolic process and RNA processing. Predicted to be located in cytosol and nucleolus. Predicted to be part of nuclear exosome (RNase complex). Predicted to be active in cytoplasm. Is expressed in several structures, including cerebral cortex; early conceptus; gonad; liver; and submandibular gland primordium. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1F. Orthologous to human EXOSC1 (exosome component 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA catabolic process, RNA processing, rRNA processing; MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleus
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9DAA6
Entrez ID: 66583
|
Does Knockout of Prtn3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Prtn3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Prtn3 (proteinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-cell junction maintenance, collagen catabolic process, mature conventional dendritic cell differentiation, membrane protein ectodomain proteolysis, negative regulation of phagocytosis, neutrophil extravasation, proteolysis; MF: enzyme binding, hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity, signaling receptor binding; CC: azurophil granule lumen, cytoplasm, cytosol, extracellular region, extracellular space, lysosome, membrane, membrane raft, plasma membrane, plasma membrane raft
Pathways: Antimicrobial peptides, Common Pathway of Fibrin Clot Formation, Formation of Fibrin Clot (Clotting Cascade), Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q61096
Entrez ID: 19152
|
Does Knockout of Caprin1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Caprin1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Caprin1 (cell cycle associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, deadenylation-dependent decapping of nuclear-transcribed mRNA, generation of neurons, intracellular mRNA localization, membraneless organelle assembly, negative regulation of translation, negative regulation of translational initiation, nervous system development, positive regulation of dendrite morphogenesis, positive regulation of dendritic spine morphogenesis, positive regulation of stress granule assembly, regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA, stress granule assembly, synapse assembly, synapse organization; MF: ATP binding, RNA binding, mRNA binding, molecular condensate scaffold activity, molecular function activator activity, nucleotide binding, signaling adaptor activity; CC: P-body, cell leading edge, cell projection, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, dendrite, glutamatergic synapse, lamellipodium, postsynapse, synapse
Pathways:
UniProt: Q60865
Entrez ID: 53872
|
Does Knockout of Pex2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Pex2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pex2 (peroxisomal biogenesis factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid biosynthetic process, cellular response to reactive oxygen species, cholesterol homeostasis, fatty acid beta-oxidation, negative regulation of epithelial cell proliferation, negative regulation of fibroblast proliferation, nervous system development, neuron migration, peroxisome organization, pexophagy, protein destabilization, protein import into peroxisome matrix, protein import into peroxisome matrix, receptor recycling, protein import into peroxisome matrix, substrate release, protein monoubiquitination, protein transport, protein ubiquitination, protein unfolding, regulation of cholesterol biosynthetic process, response to amino acid starvation, very long-chain fatty acid metabolic process; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: Cdc73/Paf1 complex, membrane, nucleoplasm, peroxisomal membrane, peroxisome
Pathways: Class I peroxisomal membrane protein import, E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Post-translational protein modification, Protein localization, Protein ubiquitination
UniProt: P55098
Entrez ID: 19302
|
Does Knockout of Acadl in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Acadl
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Acadl (acyl-Coenzyme A dehydrogenase, long-chain)
Type: protein-coding
Summary: This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: carnitine catabolic process, carnitine metabolic process, CoA-linked, fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid catabolic process, fatty acid metabolic process, lipid catabolic process, lipid metabolic process, long-chain fatty acid catabolic process, negative regulation of fatty acid biosynthetic process, negative regulation of fatty acid oxidation, positive regulation of cold-induced thermogenesis, regulation of cholesterol metabolic process, response to cold, temperature homeostasis; MF: acyl-CoA dehydrogenase activity, flavin adenine dinucleotide binding, long-chain fatty acyl-CoA dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, protein homodimerization activity; CC: cytoplasm, mitochondrial matrix, mitochondrial membrane, mitochondrion
Pathways: Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA, Beta oxidation of myristoyl-CoA to lauroyl-CoA, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, PPAR signaling pathway - Mus musculus (mouse), mitochondrial fatty acid beta-oxidation of saturated fatty acids
UniProt: P51174
Entrez ID: 11363
|
Does Knockout of Pgd in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Pgd
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Pgd (phosphogluconate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-gluconate metabolic process, NADP+ metabolic process, NADPH regeneration, pentose biosynthetic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch; MF: NADP binding, carbohydrate binding, carboxylic acid binding, oxidoreductase activity, phosphogluconate dehydrogenase (decarboxylating) activity; CC: cytoplasm, cytosol
Pathways: Glutathione metabolism - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), pentose phosphate pathway, pentose phosphate pathway (oxidative branch)
UniProt: Q9DCD0
Entrez ID: 110208
|
Does Knockout of Usp17la in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Usp17la
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Usp17la (ubiquitin specific peptidase 17-like A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of apoptotic process, regulation of protein stability; MF: RNA binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hyaluronic acid binding, hydrolase activity, lncRNA binding, peptidase activity; CC: cytoplasm, cytosol, endoplasmic reticulum membrane, nucleolus, nucleus
Pathways: Deubiquitination, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Metabolism of proteins, Post-translational protein modification, RAF/MAP kinase cascade, RAS processing, Signal Transduction, Ub-specific processing proteases
UniProt: Q61068
Entrez ID: 13531
|
Does Knockout of Gtf2e2 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Gtf2e2
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, TFIIH-class transcription factor complex binding, protein binding; CC: cytosol, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIE complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q9D902
Entrez ID: 68153
|
Does Knockout of Ddx56 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Ddx56
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ddx56 (DEAD box helicase 56)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic pattern recognition receptor signaling pathway, defense response to virus, host-mediated perturbation of viral RNA genome replication, negative regulation of type I interferon production, positive regulation of neuron projection development, protein import into nucleus, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA stem-loop binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein sequestering activity; CC: cytosol, nucleolus, nucleus
Pathways:
UniProt: Q9D0R4
Entrez ID: 52513
|
Does Knockout of Tmed1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Tmed1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tmed1 (transmembrane p24 trafficking protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport; CC: COPII-coated ER to Golgi transport vesicle, Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, plasma membrane
Pathways:
UniProt: Q3V009
Entrez ID: 17083
|
Does Knockout of Gstm2 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Gstm2
|
phagocytosis
|
macrophage
|
Gene: Gstm2 (glutathione S-transferase, mu 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutathione metabolic process, hepoxilin biosynthetic process, lipid metabolic process, xenobiotic catabolic process; MF: enzyme binding, glutathione binding, glutathione transferase activity, identical protein binding, protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion, protein-containing complex
Pathways: Azathioprine ADME, Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug ADME, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Paracetamol ADME, Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: P15626
Entrez ID: 14863
|
Does Knockout of Fbxl19 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Fbxl19
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fbxl19 (F-box and leucine-rich repeat protein 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, chromatin remodeling, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of transcription by RNA polymerase II; MF: DNA binding, histone demethylase activity, metal ion binding, protein binding, transcription coregulator activity, ubiquitin-like ligase-substrate adaptor activity, unmethylated CpG binding, zinc ion binding
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q6PB97
Entrez ID: 233902
|
Does Knockout of Srp68 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Srp68
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Srp68 (signal recognition particle 68)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, response to xenobiotic stimulus; MF: 7S RNA binding, RNA binding, endoplasmic reticulum signal peptide binding, protein domain specific binding, ribosome binding, signal recognition particle binding; CC: cytoplasm, cytosol, endoplasmic reticulum, focal adhesion, nucleolus, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Mus musculus (mouse), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: Q8BMA6
Entrez ID: 217337
|
Does Knockout of Luzp2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Luzp2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Luzp2 (leucine zipper protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: Q8BGY3
Entrez ID: 233271
|
Does Knockout of Mesp2 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Mesp2
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Mesp2 (mesoderm posterior 2)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including mesodermal cell migration; signal transduction involved in regulation of gene expression; and somite rostral/caudal axis specification. Located in nucleus. Is expressed in several structures, including central nervous system; ear; embryo mesoderm; genitourinary system; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 2. Orthologous to human MESP2 (mesoderm posterior bHLH transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Notch signaling pathway, heart morphogenesis, mesoderm formation, mesodermal cell migration, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, signal transduction involved in regulation of gene expression, somite rostral/caudal axis specification, somitogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: O08574
Entrez ID: 17293
|
Does Knockout of Tst in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Tst
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tst (thiosulfate sulfurtransferase, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial cell differentiation, rRNA import into mitochondrion, rRNA transport; MF: 3-mercaptopyruvate sulfurtransferase activity, 5S rRNA binding, RNA binding, sulfurtransferase activity, thiosulfate-cyanide sulfurtransferase activity, transferase activity; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Degradation of cysteine and homocysteine, Metabolism, Metabolism of amino acids and derivatives, Sulfur amino acid metabolism, Sulfur metabolism - Mus musculus (mouse), Sulfur relay system - Mus musculus (mouse), thiosulfate disproportionation III (rhodanese)
UniProt: P52196
Entrez ID: 22117
|
Does Knockout of Krtap4-2 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Krtap4-2
|
phagocytosis
|
macrophage
|
Gene: Krtap4-2 (keratin associated protein 4-2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, hair cycle; CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: B1AQ85
Entrez ID: 68673
|
Does Knockout of Nagk in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Nagk
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nagk (N-acetylglucosamine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-acetylglucosamine catabolic process, N-acetylglucosamine metabolic process, N-acetylneuraminate catabolic process, UDP-N-acetylglucosamine biosynthetic process, canonical NF-kappaB signal transduction, carbohydrate phosphorylation, defense response to bacterium, immune system process, innate immune response, negative regulation of canonical NF-kappaB signal transduction, nucleotide-binding oligomerization domain containing 2 signaling pathway, p38MAPK cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, protein K63-linked ubiquitination, protein linear polyubiquitination, response to muramyl dipeptide; MF: ATP binding, N-acetylglucosamine kinase activity, N-acylmannosamine kinase activity, kinase activity, muramyl dipeptide kinase activity, nucleotide binding, transferase activity
Pathways: <i>N</i>-acetylglucosamine degradation II, Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, Post-translational protein modification, Synthesis of UDP-N-acetyl-glucosamine, Synthesis of substrates in N-glycan biosythesis
UniProt: Q9QZ08
Entrez ID: 56174
|
Does Knockout of Sac3d1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Sac3d1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sac3d1 (SAC3 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome duplication, negative regulation of receptor signaling pathway via JAK-STAT, regulation of immune response, spindle assembly; CC: centrosome, cytoplasm, cytoskeleton, microtubule cytoskeleton, nucleus, spindle
Pathways:
UniProt: A6H687
Entrez ID: 66406
|
Does Knockout of Rpl4 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Rpl4
|
phagocytosis
|
macrophage
|
Gene: Rpl4 (ribosomal protein L4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: 5S rRNA binding, RNA binding, protein binding, structural constituent of ribosome; CC: A band, cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, large ribosomal subunit, nuclear body, nucleolus, nucleus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D8E6
Entrez ID: 67891
|
Does Knockout of Ndc1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Ndc1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ndc1 (NDC1 transmembrane nucleoporin)
Type: protein-coding
Summary: Predicted to enable protein-macromolecule adaptor activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within homologous chromosome pairing at meiosis and spermatogenesis. Located in cytoplasm. Part of nuclear pore. Is expressed in several structures, including forelimb bud; gonad; lung; and spleen. Orthologous to human NDC1 (NDC1 transmembrane nucleoporin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: homologous chromosome pairing at meiosis, mRNA transport, nuclear pore complex assembly, nuclear pore localization, nuclear pore organization, nucleocytoplasmic transport, protein transport, spermatogenesis; MF: protein-macromolecule adaptor activity, structural constituent of nuclear pore; CC: actin cytoskeleton, cytoplasm, membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore transmembrane ring, nucleus, plasma membrane
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8VCB1
Entrez ID: 72787
|
Does Knockout of Notch1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Notch1
|
cell cycle progression
|
breast epithelium
|
Gene: Notch1 (notch 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation, T-helper 17 type immune response, angiogenesis, animal organ regeneration, aortic valve morphogenesis, apoptotic process involved in embryonic digit morphogenesis, arterial endothelial cell differentiation, artery morphogenesis, astrocyte differentiation, atrioventricular node development, atrioventricular valve morphogenesis, auditory receptor cell fate commitment, axon guidance, axonogenesis, branching morphogenesis of an epithelial tube, camera-type eye morphogenesis, cardiac atrium morphogenesis, cardiac chamber formation, cardiac epithelial to mesenchymal transition, cardiac left ventricle morphogenesis, cardiac muscle cell myoblast differentiation, cardiac muscle cell proliferation, cardiac muscle tissue morphogenesis, cardiac right atrium morphogenesis, cardiac right ventricle formation, cardiac septum morphogenesis, cardiac vascular smooth muscle cell development, cardiac ventricle morphogenesis, cell differentiation, cell differentiation in spinal cord, cell fate commitment, cell migration involved in endocardial cushion formation, cellular response to follicle-stimulating hormone stimulus, cellular response to hypoxia, cellular response to tumor cell, cellular response to vascular endothelial growth factor stimulus, central nervous system neuron differentiation, chemical synaptic transmission, postsynaptic, cilium assembly, collecting duct development, compartment pattern specification, coronary artery morphogenesis, coronary sinus valve morphogenesis, coronary vein morphogenesis, determination of left/right symmetry, developmental growth, distal tubule development, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, endocardial cell differentiation, endocardial cushion development, endocardial cushion morphogenesis, endocardium development, endocardium morphogenesis, endoderm development, epidermal cell fate specification, epidermis development, epithelial cell development, epithelial cell differentiation involved in kidney development, epithelial cell fate commitment, epithelial to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, forebrain development, foregut morphogenesis, gene expression, glial cell differentiation, glomerular mesangial cell development, glomerulus vasculature development, growth involved in heart morphogenesis, hair follicle morphogenesis, heart development, heart looping, heart trabecula morphogenesis, homeostasis of number of cells within a tissue, humoral immune response, in utero embryonic development, inflammatory response to antigenic stimulus, inhibition of neuroepithelial cell differentiation, interleukin-17-mediated signaling pathway, keratinocyte differentiation, left/right axis specification, liver development, lung development, luteolysis, mesenchymal cell development, mitral valve formation, morphogenesis of an epithelial sheet, negative regulation of BMP signaling pathway, negative regulation of DNA-templated transcription, negative regulation of anoikis, negative regulation of biomineral tissue development, negative regulation of calcium ion-dependent exocytosis, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cardiac muscle hypertrophy, negative regulation of catalytic activity, negative regulation of cell adhesion molecule production, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of cell population proliferation, negative regulation of cell proliferation involved in heart valve morphogenesis, negative regulation of cell-cell adhesion mediated by cadherin, negative regulation of cell-substrate adhesion, negative regulation of cold-induced thermogenesis, negative regulation of collagen biosynthetic process, negative regulation of endothelial cell chemotaxis, negative regulation of epithelial cell proliferation, negative regulation of extracellular matrix constituent secretion, negative regulation of gene expression, negative regulation of glial cell proliferation, negative regulation of inner ear auditory receptor cell differentiation, negative regulation of myoblast differentiation, negative regulation of myotube differentiation, negative regulation of neurogenesis, negative regulation of neuron differentiation, negative regulation of oligodendrocyte differentiation, negative regulation of ossification, negative regulation of osteoblast differentiation, negative regulation of photoreceptor cell differentiation, negative regulation of pro-B cell differentiation, negative regulation of programmed cell death, negative regulation of stem cell differentiation, negative regulation of transcription by RNA polymerase II, nephron tubule development, neural tube development, neuroendocrine cell differentiation, neuron differentiation, neuron fate commitment, neuronal stem cell population maintenance, oligodendrocyte differentiation, osteoblast fate commitment, outflow tract morphogenesis, pericardium morphogenesis, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of Notch signaling pathway, positive regulation of Ras protein signal transduction, positive regulation of aorta morphogenesis, positive regulation of apoptotic process, positive regulation of apoptotic process involved in morphogenesis, positive regulation of astrocyte differentiation, positive regulation of cardiac epithelial to mesenchymal transition, positive regulation of cardiac muscle cell proliferation, positive regulation of cell development, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of endothelial cell differentiation, positive regulation of ephrin receptor signaling pathway, positive regulation of epithelial cell differentiation, positive regulation of epithelial cell proliferation, positive regulation of epithelial to mesenchymal transition, positive regulation of gene expression, positive regulation of glial cell differentiation, positive regulation of keratinocyte differentiation, positive regulation of neuroblast proliferation, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of smooth muscle cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of Notch receptor target, positive regulation of viral genome replication, positive regulation of viral transcription, prostate gland epithelium morphogenesis, protein catabolic process, protein import into nucleus, pulmonary valve morphogenesis, regulation of DNA-templated transcription, regulation of Notch signaling pathway, regulation of apoptotic process, regulation of cardioblast proliferation, regulation of cell adhesion involved in heart morphogenesis, regulation of cell migration, regulation of cell population proliferation, regulation of developmental process, regulation of epithelial cell proliferation, regulation of epithelial cell proliferation involved in prostate gland development, regulation of extracellular matrix assembly, regulation of gene expression, regulation of inner ear auditory receptor cell differentiation, regulation of neurogenesis, regulation of secondary heart field cardioblast proliferation, regulation of somitogenesis, regulation of stem cell proliferation, regulation of transcription by RNA polymerase II, reproductive structure development, response to lipopolysaccharide, response to muramyl dipeptide, retinal cone cell differentiation, secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development, skeletal muscle cell differentiation, somatic stem cell division, spermatogenesis, sprouting angiogenesis, tissue regeneration, tube formation, vasculogenesis involved in coronary vascular morphogenesis, venous blood vessel morphogenesis, venous endothelial cell differentiation, ventricular septum morphogenesis, ventricular trabecula myocardium morphogenesis; MF: Notch binding, calcium ion binding, chromatin DNA binding, chromatin binding, enzyme binding, enzyme inhibitor activity, identical protein binding, metal ion binding, protein binding, signaling receptor activity, transcription coactivator activity, transcription regulator activator activity, transmembrane signaling receptor activity; CC: Golgi membrane, MAML1-RBP-Jkappa- ICN1 complex, Schaffer collateral - CA1 synapse, acrosomal vesicle, adherens junction, apical plasma membrane, cell periphery, cell surface, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, extracellular region, glutamatergic synapse, lamellipodium, late endosome membrane, membrane, nucleoplasm, nucleus, plasma membrane, postsynaptic density membrane, receptor complex, ruffle
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Breast cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Human papillomavirus infection - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), NOTCH1 Intracellular Domain Regulates Transcription, Notch signaling pathway - Mus musculus (mouse), Notch-HLH transcription pathway, Pathways in cancer - Mus musculus (mouse), Pre-NOTCH Expression and Processing, Pre-NOTCH Processing in Golgi, Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, RUNX3 regulates NOTCH signaling, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Th1 and Th2 cell differentiation - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional regulation by RUNX3
UniProt: Q01705
Entrez ID: 18128
|
Does Knockout of Naa10 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Naa10
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Naa10 (N(alpha)-acetyltransferase 10, NatA catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric; MF: N-acetyltransferase activity, acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, protein N-terminal-serine acetyltransferase activity, protein binding, protein-N-terminal amino-acid acetyltransferase activity, protein-N-terminal-alanine acetyltransferase activity, protein-N-terminal-glutamate acetyltransferase activity, ribosome binding, transferase activity; CC: NatA complex, cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt: Q9QY36
Entrez ID: 56292
|
Does Knockout of Kcnmb3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Kcnmb3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Kcnmb3 (potassium large conductance calcium-activated channel, subfamily M, beta member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, detection of calcium ion, monoatomic ion transmembrane transport, monoatomic ion transport, neuronal action potential, potassium ion transmembrane transport, potassium ion transport; MF: calcium-activated potassium channel activity, potassium channel regulator activity; CC: membrane, plasma membrane, voltage-gated potassium channel complex
Pathways: Ca2+ activated K+ channels, Insulin secretion - Mus musculus (mouse), Neuronal System, Potassium Channels, Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: E9Q7U0
Entrez ID: 100502876
|
Does Knockout of Prmt3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Prmt3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Prmt3 (protein arginine N-methyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, dendritic spine morphogenesis, methylation, negative regulation of protein ubiquitination, negative regulation of retinoic acid biosynthetic process, positive regulation of osteoblast differentiation, regulation of DNA-templated transcription, transcription initiation-coupled chromatin remodeling; MF: histone H4R3 methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, modified amino acid binding, protein-arginine N-methyltransferase activity, protein-arginine omega-N asymmetric methyltransferase activity, protein-arginine omega-N monomethyltransferase activity, transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Metabolism of proteins, Post-translational protein modification, Protein methylation, RMTs methylate histone arginines
UniProt: Q922H1
Entrez ID: 71974
|
Does Knockout of Srek1ip1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Srek1ip1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Srek1ip1 (splicing regulatory glutamine/lysine-rich protein 1interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing; MF: metal ion binding, molecular_function, nucleic acid binding, zinc ion binding
Pathways:
UniProt: Q4V9W2
Entrez ID: 67288
|
Does Knockout of Chrna3 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Chrna3
|
phagocytosis
|
macrophage
|
Gene: Chrna3 (cholinergic receptor, nicotinic, alpha polypeptide 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine receptor signaling pathway, behavioral response to nicotine, excitatory postsynaptic potential, locomotory behavior, membrane depolarization, monoatomic ion transmembrane transport, monoatomic ion transport, nervous system development, neuromuscular synaptic transmission, presynaptic modulation of chemical synaptic transmission, regulation of acetylcholine secretion, neurotransmission, regulation of amine transport, regulation of dendrite morphogenesis, regulation of membrane potential, regulation of muscle contraction, regulation of smooth muscle contraction, response to acetylcholine, response to nicotine, response to xenobiotic stimulus, signal transduction, synaptic transmission involved in micturition, synaptic transmission, cholinergic; MF: acetylcholine binding, acetylcholine receptor activity, acetylcholine-gated monoatomic cation-selective channel activity, extracellular ligand-gated monoatomic ion channel activity, heterocyclic compound binding, metal ion binding, monoatomic ion channel activity, protein binding, protein-containing complex binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: Golgi apparatus, acetylcholine-gated channel complex, cation channel complex, cholinergic synapse, ciliary basal body, cytosol, dendrite, dopaminergic synapse, endoplasmic reticulum, membrane, neuron projection, neuronal cell body, neurotransmitter receptor complex, nuclear speck, nucleolus, plasma membrane, plasma membrane raft, postsynaptic membrane, postsynaptic specialization membrane, presynapse, protein-containing complex, synapse, synaptic membrane
Pathways: Acetylcholine binding and downstream events, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Highly calcium permeable nicotinic acetylcholine receptors, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, Highly sodium permeable postsynaptic acetylcholine nicotinic receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Postsynaptic nicotinic acetylcholine receptors, Presynaptic nicotinic acetylcholine receptors, Transmission across Chemical Synapses
UniProt: Q8R4G9
Entrez ID: 110834
|
Does Knockout of Mdk in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Mdk
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mdk (midkine)
Type: protein-coding
Summary: This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: T cell activation involved in immune response, adrenal gland development, behavioral fear response, cell differentiation, cell migration, cerebellar granular layer development, cerebral cortex development, cytoskeleton organization, defecation, dentate gyrus development, estrous cycle, glial cell projection elongation, hippocampus development, intracellular signal transduction, leukocyte chemotaxis involved in inflammatory response, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell adhesion, negative regulation of epithelial cell apoptotic process, negative regulation of inflammatory response to wounding, negative regulation of neuron apoptotic process, negative regulation of ossification, negative regulation of regulatory T cell differentiation, oogenesis, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of artery morphogenesis, positive regulation of blood vessel branching, positive regulation of cartilage development, positive regulation of cell adhesion, positive regulation of cell division, positive regulation of cell migration, positive regulation of epithelial to mesenchymal transition, positive regulation of hepatocyte proliferation, positive regulation of inflammatory response, positive regulation of inflammatory response to wounding, positive regulation of interleukin-12 production, positive regulation of keratinocyte proliferation, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of leukocyte cell-cell adhesion, positive regulation of leukocyte chemotaxis, positive regulation of macrophage chemotaxis, positive regulation of neural precursor cell proliferation, positive regulation of neuron migration, positive regulation of neuron projection development, positive regulation of neutrophil chemotaxis, positive regulation of neutrophil extravasation, positive regulation of oligodendrocyte differentiation, positive regulation of smooth muscle cell chemotaxis, positive regulation of substrate adhesion-dependent cell spreading, positive regulation of vascular endothelial cell proliferation, regulation of behavior, regulation of bone remodeling, regulation of chondrocyte differentiation, regulation of neural precursor cell proliferation, response to auditory stimulus, response to glucocorticoid, response to hormone, response to wounding, response to xenobiotic stimulus, short-term memory, tissue regeneration; MF: chondroitin sulfate binding, growth factor activity, heparan sulfate binding, heparin binding, protein binding; CC: cell projection, extracellular region
Pathways: MDK and PTN in ALK signaling, Signal Transduction, Signaling by ALK, Signaling by Receptor Tyrosine Kinases
UniProt: P12025
Entrez ID: 17242
|
Does Knockout of Rtp1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Rtp1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Rtp1 (receptor transporter protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of chemical stimulus involved in sensory perception of bitter taste, protein insertion into membrane, protein targeting to membrane; MF: metal ion binding, olfactory receptor binding, zinc ion binding; CC: cell surface, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8C8C1
Entrez ID: 239766
|
Does Knockout of Prl2c1 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Prl2c1
|
response to virus
|
Microglial Cell Line
|
Gene: Prl2c1 (Prolactin family 2, subfamily c, member 1)
Type: protein-coding
Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels; MF: hormone activity, metal ion binding, prolactin receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q5SVM0, Q5SVL9
Entrez ID: 666317
|
Does Knockout of Snhg11 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Snhg11
|
phagocytosis
|
macrophage
|
Gene: Snhg11 (small nucleolar RNA host gene 11)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 319317
|
Does Knockout of Adam1a in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Adam1a
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Adam1a (a disintegrin and metallopeptidase domain 1a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, fusion of sperm to egg plasma membrane involved in single fertilization, male gonad development, proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein binding; CC: external side of plasma membrane, membrane, membrane raft, plasma membrane, sperm head plasma membrane
Pathways:
UniProt: Q60813
Entrez ID: 280668
|
Does Knockout of Zfp583 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Zfp583
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Zfp583 (zinc finger protein 583)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q3V080
Entrez ID: 213011
|
Does Knockout of Nox4 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Nox4
|
phagocytosis
|
macrophage
|
Gene: Nox4 (NADPH oxidase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone resorption, cardiac muscle cell differentiation, cell morphogenesis, defense response, gene expression, heart process, homocysteine metabolic process, intracellular signal transduction, negative regulation of cell population proliferation, positive regulation of DNA biosynthetic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAP kinase activity, positive regulation of apoptotic process, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of reactive oxygen species metabolic process, positive regulation of smooth muscle cell migration, positive regulation of stress fiber assembly, reactive oxygen species metabolic process, superoxide anion generation, superoxide metabolic process; MF: NAD(P)H oxidase H2O2-forming activity, heme binding, modified amino acid binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor, protein tyrosine kinase binding, superoxide-generating NAD(P)H oxidase activity, superoxide-generating NADPH oxidase activity; CC: NADPH oxidase complex, anchoring junction, apical plasma membrane, cell periphery, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, focal adhesion, membrane, mitochondrion, nucleolus, nucleus, perinuclear endoplasmic reticulum, perinuclear region of cytoplasm, plasma membrane, sarcoplasmic reticulum, stress fiber
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Detoxification of Reactive Oxygen Species, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse)
UniProt: Q9JHI8
Entrez ID: 50490
|
Does Knockout of Ralgapb in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Ralgapb
|
cell cycle progression
|
breast epithelium
|
Gene: Ralgapb (Ral GTPase activating protein, beta subunit (non-catalytic))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ral protein signal transduction, activation of GTPase activity, regulation of exocyst localization, regulation of protein localization, regulation of small GTPase mediated signal transduction; MF: GTPase activator activity, protein heterodimerization activity
Pathways:
UniProt: A2ACC6, E9Q0J2, F8WHN4, A2ACC7, A2APV5
Entrez ID: 228850
|
Does Knockout of Mbd4 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,553
|
Knockout
|
Mbd4
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Mbd4 (methyl-CpG binding domain protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, intrinsic apoptotic signaling pathway in response to DNA damage, mitotic G2 DNA damage checkpoint signaling, response to radiation; MF: DNA binding, catalytic activity, hydrolase activity, pyrimidine-specific mismatch base pair DNA N-glycosylase activity; CC: chromatin, cytoplasm, nuclear speck, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Base-Excision Repair, AP Site Formation, Cleavage of the damaged pyrimidine , DNA Repair, Depyrimidination, Displacement of DNA glycosylase by APEX1, Resolution of Abasic Sites (AP sites)
UniProt: Q9Z2D7
Entrez ID: 17193
|
Does Knockout of Fignl2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Fignl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fignl2 (fidgetin-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule severing, morphogenesis of a branching structure, negative regulation of axon regeneration, negative regulation of cell migration, negative regulation of wound healing, spreading of epidermal cells; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, microtubule severing ATPase activity, nucleotide binding; CC: cell cortex, cell leading edge, cytoplasm, nucleus
Pathways:
UniProt: J3QK54
Entrez ID: 668225
|
Does Knockout of Kazald1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Kazald1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kazald1 (Kazal-type serine peptidase inhibitor domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, extracellular matrix organization, ossification, regulation of cell growth, regulation of signal transduction; CC: extracellular matrix, extracellular region, extracellular space, interstitial matrix
Pathways:
UniProt: Q8BJ66
Entrez ID: 107250
|
Does Knockout of Dmc1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Dmc1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Dmc1 (DNA meiotic recombinase 1)
Type: protein-coding
Summary: This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. In mouse, deficiency of this gene causes infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
Gene Ontology: BP: DNA metabolic process, DNA recombinase assembly, DNA repair, DNA strand invasion, chromosome organization involved in meiotic cell cycle, double-strand break repair involved in meiotic recombination, double-strand break repair via homologous recombination, female gamete generation, gamete generation, homologous chromosome pairing at meiosis, male meiosis I, meiotic cell cycle, mitotic recombination, oocyte maturation, oogenesis, ovarian follicle development, reciprocal meiotic recombination, spermatid development, spermatogenesis; MF: ATP binding, ATP-dependent DNA damage sensor activity, ATP-dependent activity, acting on DNA, DNA binding, DNA strand exchange activity, catalytic activity, acting on DNA, double-stranded DNA binding, identical protein binding, nucleotide binding, single-stranded DNA binding; CC: chromosome, chromosome, telomeric region, condensed nuclear chromosome, lateral element, nucleoplasm, nucleus, site of double-strand break
Pathways: Cell Cycle, Meiosis, Meiotic recombination, Reproduction
UniProt: Q61880
Entrez ID: 13404
|
Does Knockout of Plec in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Plec
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Plec (plectin)
Type: protein-coding
Summary: Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). It has been shown that the short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (human variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: T cell chemotaxis, actin cytoskeleton organization, actin filament organization, actomyosin contractile ring assembly actin filament organization, adherens junction organization, cardiac muscle cell development, cell morphogenesis, cell motility, cellular response to fluid shear stress, cellular response to hydrostatic pressure, cellular response to mechanical stimulus, epithelial cell differentiation, establishment of skin barrier, fibroblast migration, gene expression, hemidesmosome assembly, intermediate filament cytoskeleton organization, intermediate filament organization, intracellular protein localization, keratinocyte development, keratinocyte differentiation, leukocyte migration involved in immune response, mitochondrion organization, multicellular organism growth, myelination in peripheral nervous system, myoblast differentiation, nucleus organization, peripheral nervous system myelin maintenance, protein-containing complex organization, regulation of vascular permeability, respiratory electron transport chain, response to food, response to nutrient, response to nutrient levels, sarcomere organization, skeletal muscle fiber development, skeletal muscle tissue development, skeletal myofibril assembly, skin development, tight junction organization, transmission of nerve impulse, wound healing; MF: actin binding, actin filament binding, ankyrin binding, cytoskeletal protein binding, dystroglycan binding, identical protein binding, protein binding, structural constituent of cytoskeleton, structural constituent of muscle; CC: Z disc, anchoring junction, apical plasma membrane, axon, basal plasma membrane, brush border, cell periphery, cell projection, contractile muscle fiber, cytoplasm, cytoskeleton, cytosol, dendrite, focal adhesion, hemidesmosome, intermediate filament, intermediate filament cytoskeleton, mitochondrial outer membrane, myelin sheath, myofibril, perinuclear region of cytoplasm, podosome, sarcolemma, sarcoplasm
Pathways:
UniProt: Q9QXS1
Entrez ID: 18810
|
Does Knockout of Nup188 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Nup188
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Nup188 (nucleoporin 188)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein import into nucleus, protein transport; MF: structural constituent of nuclear pore; CC: nuclear envelope, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q6ZQH8
Entrez ID: 227699
|
Does Knockout of Brd3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Brd3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Brd3 (bromodomain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, endodermal cell differentiation, positive regulation of transcription by RNA polymerase II, protein localization to chromatin, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: histone H3K18cr reader activity, histone H3K27cr reader activity, histone H3K9cr reader activity, histone H3K9me2/3 reader activity, histone reader activity, lncRNA binding, molecular condensate scaffold activity; CC: chromatin, chromosome, nucleus
Pathways:
UniProt: Q8K2F0
Entrez ID: 67382
|
Does Knockout of Tex30 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Tex30
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Tex30 (testis expressed 30)
Type: protein-coding
Summary: Is expressed in diencephalon lateral wall ventricular layer; midbrain ventricular layer; and telencephalon ventricular layer. Orthologous to human TEX30 (testis expressed 30). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q3TUU5
Entrez ID: 75623
|
Does Knockout of Dnm1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Dnm1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dnm1 (dynamin 1)
Type: protein-coding
Summary: This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: G protein-coupled receptor internalization, clathrin coat assembly involved in endocytosis, endocytosis, endosome organization, modulation of chemical synaptic transmission, positive regulation of synaptic vesicle endocytosis, positive regulation of synaptic vesicle recycling, protein homooligomerization, protein homotetramerization, receptor internalization, receptor-mediated endocytosis, regulation of synaptic vesicle endocytosis, regulation of vesicle size, synaptic vesicle budding from presynaptic endocytic zone membrane, synaptic vesicle endocytosis, vesicle scission; MF: D2 dopamine receptor binding, GDP binding, GTP binding, GTPase activity, SH3 domain binding, hydrolase activity, identical protein binding, microtubule binding, nitric-oxide synthase binding, nucleotide binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein homodimerization activity, protein kinase binding, protein serine/threonine kinase binding, protein-containing complex binding; CC: Golgi apparatus, cell projection, chromaffin granule, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, endocytic vesicle, glutamatergic synapse, membrane, membrane coat, microtubule, myelin sheath, photoreceptor inner segment, photoreceptor ribbon synapse, plasma membrane, presynapse, presynaptic endocytic zone membrane, protein-containing complex, synapse, synaptic vesicle, varicosity
Pathways: Adaptive Immune System, Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Immune System, Innate Immune System, L1CAM interactions, MHC class II antigen presentation, Membrane Trafficking, Nervous system development, Phospholipase D signaling pathway - Mus musculus (mouse), Recycling pathway of L1, Synaptic vesicle cycle - Mus musculus (mouse), Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Vesicle-mediated transport
UniProt: P39053
Entrez ID: 13429
|
Does Knockout of Ddrgk1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ddrgk1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ddrgk1 (DDRGK domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cartilage development, negative regulation of IRE1-mediated unfolded protein response, negative regulation of PERK-mediated unfolded protein response, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of I-kappaB phosphorylation, positive regulation of NF-kappaB transcription factor activity, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of plasma cell differentiation, positive regulation of proteasomal protein catabolic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein localization to endoplasmic reticulum, positive regulation of proteolysis involved in protein catabolic process, positive regulation of reticulophagy, positive regulation of transcription by RNA polymerase II, protein K69-linked ufmylation, protein localization to endoplasmic reticulum, protein ufmylation, regulation of intracellular estrogen receptor signaling pathway, regulation of protein stability, rescue of stalled ribosome, response to endoplasmic reticulum stress, reticulophagy, ribosome disassembly; MF: UFM1-modified protein reader activity, protein binding, ubiquitin-like protein ligase binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80WW9
Entrez ID: 77006
|
Does Knockout of Cmtm3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Cmtm3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cmtm3 (CKLF-like MARVEL transmembrane domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst hatching, chemotaxis, positive regulation of B cell receptor signaling pathway, signal transduction; MF: cytokine activity, protein binding; CC: cytoplasm, cytoplasmic vesicle, cytosol, extracellular space, membrane, nuclear membrane
Pathways:
UniProt: Q99LJ5
Entrez ID: 68119
|
Does Knockout of Slc22a19 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Slc22a19
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Slc22a19 (solute carrier family 22 (organic anion transporter), member 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, organic anion transport, response to molecule of fungal origin, transmembrane transport; MF: organic anion transmembrane transporter activity, short-chain fatty acid transmembrane transporter activity, sodium-independent organic anion transmembrane transporter activity, toxin transmembrane transporter activity, transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q8VCA0
Entrez ID: 207151
|
Does Knockout of Sprr3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Sprr3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Sprr3 (small proline-rich protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, cytoplasm, perinuclear region of cytoplasm
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: O09116
Entrez ID: 20766
|
Does Knockout of Mfsd9 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Mfsd9
|
response to virus
|
Microglial Cell Line
|
Gene: Mfsd9 (major facilitator superfamily domain containing 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C0T7
Entrez ID: 211798
|
Does Knockout of Gm13290 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Gm13290
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gm13290 (predicted gene 13290)
Type: protein-coding
Summary: predicted gene 13290
Gene Ontology:
Pathways:
UniProt: Q8CD73
Entrez ID: 545646
|
Does Knockout of Fut1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Fut1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fut1 (fucosyltransferase 1)
Type: protein-coding
Summary: This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is required for the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene impairs development of the olfactory nerve and maturation of the glomerular layer of the main olfactory bulb. Alternative splicing results in multiple transcript variants which encode distinct isoforms. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: carbohydrate metabolic process, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to low-density lipoprotein particle stimulus, cellular response to xenobiotic stimulus, endoplasmic reticulum unfolded protein response, endothelial cell apoptotic process, fucosylation, glycolipid metabolic process, glycoprotein biosynthetic process, lipid metabolic process, negative regulation of endothelial cell apoptotic process, olfactory bulb development, oligosaccharide biosynthetic process, positive regulation of cell-matrix adhesion, positive regulation of endothelial cell migration, positive regulation of endothelial cell-matrix adhesion via fibronectin, positive regulation of sprouting angiogenesis, positive regulation of triglyceride catabolic process, protein O-linked glycosylation via fucose, protein glycosylation, response to activity, response to methionine, response to nutrient levels; MF: alpha-(1,2)-fucosyltransferase activity, fucosyltransferase activity, galactoside 2-alpha-L-fucosyltransferase activity, glycosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, extracellular space, membrane
Pathways: ABO blood group biosynthesis, Blood group systems biosynthesis, Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - globo and isoglobo series - Mus musculus (mouse), Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Glycosphingolipid metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of lipids, Sphingolipid metabolism
UniProt: O09160
Entrez ID: 14343
|
Does Knockout of Cmbl in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Cmbl
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cmbl (carboxymethylenebutenolidase homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, molecular_function; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Metabolism, Phase I - Functionalization of compounds
UniProt: Q8R1G2
Entrez ID: 69574
|
Does Knockout of Slc25a28 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Slc25a28
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Slc25a28 (solute carrier family 25, member 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: iron import into the mitochondrion, iron ion transport, monoatomic ion transport; MF: ferrous iron transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q8R0Z5
Entrez ID: 246696
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.