prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Rabac1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Rabac1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rabac1 (Rab acceptor 1 (prenylated))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTPase binding, identical protein binding, proline-rich region binding, protein binding; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, glutamatergic synapse, membrane, plasma membrane, presynapse, synapse, synaptic vesicle
Pathways:
UniProt: Q9Z0S9
Entrez ID: 14470
|
Does Knockout of Slpi in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Slpi
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Slpi (secretory leukocyte peptidase inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, defense response to bacterium, host-mediated perturbation of symbiont process, immune response, immune system process, innate immune response, negative regulation of viral genome replication, response to lipopolysaccharide; MF: DNA binding, endopeptidase inhibitor activity, enzyme binding, mRNA binding, peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: Golgi apparatus, extracellular region, extracellular space
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P97430
Entrez ID: 20568
|
Does Knockout of Thpo in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Thpo
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Thpo (thrombopoietin)
Type: protein-coding
Summary: This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: cell population proliferation, cell surface receptor signaling pathway via STAT, megakaryocyte development, megakaryocyte differentiation, myeloid cell differentiation, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of hematopoietic stem cell proliferation, positive regulation of megakaryocyte differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein phosphorylation, thrombopoietin-mediated signaling pathway; MF: cytokine activity, hormone activity, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse)
UniProt: P40226
Entrez ID: 21832
|
Does Knockout of Zfp882 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Zfp882
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp882 (zinc finger protein 882)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8BYD7, E9Q4R4, D3Z7G7, D3Z2V3
Entrez ID: 382019
|
Does Knockout of Atp6v1c1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Atp6v1c1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atp6v1c1 (ATPase, H+ transporting, lysosomal V1 subunit C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, apical part of cell, clathrin-coated vesicle membrane, cytoplasmic vesicle, extrinsic component of synaptic vesicle membrane, membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9Z1G3
Entrez ID: 66335
|
Does Knockout of C5ar1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
C5ar1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: C5ar1 (complement component 5a receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, amyloid-beta clearance, astrocyte activation, cell proliferation in hindbrain, chemotaxis, cognition, complement component C5a signaling pathway, complement receptor mediated signaling pathway, defense response to Gram-positive bacterium, inflammatory response, mRNA transcription by RNA polymerase II, microglial cell activation, negative regulation of neuron apoptotic process, neutrophil chemotaxis, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of angiogenesis, positive regulation of cytosolic calcium ion concentration, positive regulation of epithelial cell proliferation, positive regulation of immune system process, positive regulation of macrophage chemotaxis, positive regulation of neutrophil chemotaxis, positive regulation of vascular endothelial growth factor production, presynapse organization, response to peptidoglycan, signal transduction; MF: G protein-coupled receptor activity, complement component C5a binding, complement component C5a receptor activity, complement receptor activity; CC: apical part of cell, basolateral plasma membrane, cell surface, cytoplasmic vesicle, membrane, plasma membrane
Pathways: Alcoholic liver disease - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Coronavirus disease - COVID-19 - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Immune System, Innate Immune System, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neutrophil degranulation, Neutrophil extracellular trap formation - Mus musculus (mouse), Peptide ligand-binding receptors, Regulation of Complement cascade, Signal Transduction, Signaling by GPCR, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: P30993
Entrez ID: 12273
|
Does Knockout of Acox1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Acox1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Acox1 (acyl-Coenzyme A oxidase 1, palmitoyl)
Type: protein-coding
Summary: This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: alpha-linolenic acid metabolic process, cholesterol homeostasis, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA oxidase, fatty acid catabolic process, fatty acid derivative biosynthetic process, fatty acid metabolic process, fatty acid oxidation, generation of precursor metabolites and energy, hydrogen peroxide biosynthetic process, lipid homeostasis, lipid metabolic process, long-chain fatty acid biosynthetic process, peroxisome fission, prostaglandin metabolic process, spermatogenesis, unsaturated fatty acid biosynthetic process, very long-chain fatty acid beta-oxidation, very long-chain fatty acid metabolic process; MF: FAD binding, PDZ domain binding, acyl-CoA oxidase activity, fatty acid binding, flavin adenine dinucleotide binding, long-chain fatty acyl-CoA oxidase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, protein homodimerization activity; CC: cytoplasm, cytosol, mitochondrion, peroxisomal matrix, peroxisomal membrane, peroxisome
Pathways: Alcoholic liver disease - Mus musculus (mouse), Beta-oxidation of very long chain fatty acids, Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), Peroxisomal lipid metabolism, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Propanoate metabolism - Mus musculus (mouse), Protein localization, alpha-Linolenic acid metabolism - Mus musculus (mouse), alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism, beta-Alanine metabolism - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q9R0H0
Entrez ID: 11430
|
Does Knockout of Ttc1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Ttc1
|
cell cycle progression
|
breast epithelium
|
Gene: Ttc1 (tetratricopeptide repeat domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, inflammatory response, positive regulation of inflammatory response, positive regulation of neuroinflammatory response; MF: molecular_function, protein-macromolecule adaptor activity; CC: cytosol
Pathways:
UniProt: Q91Z38
Entrez ID: 66827
|
Does Knockout of Hdac2 in Lung Cancer Cell Line causally result in tumorigenicity?
| 0
| 1,781
|
Knockout
|
Hdac2
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Hdac2 (histone deacetylase 2)
Type: protein-coding
Summary: Enables several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including circadian regulation of gene expression; eyelid development in camera-type eye; and negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including cellular response to trichostatin A; nervous system development; and regulation of signal transduction. Located in heterochromatin; nucleus; and replication fork. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cardiac muscle cell development, cellular response to hydrogen peroxide, cellular response to trichostatin A, chromatin organization, chromatin remodeling, circadian regulation of gene expression, dendrite development, embryonic digit morphogenesis, epidermal cell differentiation, eyelid development in camera-type eye, fungiform papilla formation, hair follicle placode formation, heterochromatin formation, hippocampus development, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of apoptotic process, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell proliferation, negative regulation of cell migration, negative regulation of dendritic spine development, negative regulation of gene expression, epigenetic, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of miRNA transcription, negative regulation of neuron projection development, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transcription by competitive promoter binding, negative regulation of transforming growth factor beta receptor signaling pathway, neuron differentiation, odontogenesis of dentin-containing tooth, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of epithelial to mesenchymal transition, positive regulation of interleukin-1 production, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of male mating behavior, positive regulation of oligodendrocyte differentiation, positive regulation of proteolysis, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, progesterone receptor signaling pathway, regulation of cell fate specification, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of sarcomere organization, regulation of stem cell differentiation, rhythmic process; MF: DNA-binding transcription factor binding, Krueppel-associated box domain binding, NF-kappaB binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, deacetylase activity, enzyme binding, heat shock protein binding, histone H4K16 deacetylase activity, hydrolytic mechanism, histone binding, histone deacetylase activity, histone deacetylase activity, hydrolytic mechanism, histone deacetylase binding, histone decrotonylase activity, hydrolase activity, metal ion binding, promoter-specific chromatin binding, protein binding, protein de-2-hydroxyisobutyrylase activity, protein decrotonylase activity, protein lysine deacetylase activity, protein lysine delactylase activity, transcription coregulator binding, transcription corepressor binding; CC: ESC/E(Z) complex, NuRD complex, RNA polymerase II transcription repressor complex, Sin3-type complex, chromatin, chromosome, telomeric region, cytoplasm, heterochromatin, histone deacetylase complex, nucleoplasm, nucleus, protein-containing complex, replication fork, transcription regulator complex, transcription repressor complex
Pathways: Adherens junctions interactions, Alcoholism - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Cell cycle - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chromatin modifying enzymes, Chromatin organization, Chronic myeloid leukemia - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Factors involved in megakaryocyte development and platelet production, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Hemostasis, Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Intracellular signaling by second messengers, Longevity regulating pathway - multiple species - Mus musculus (mouse), Metabolism of proteins, MicroRNAs in cancer - Mus musculus (mouse), Negative Regulation of CDH1 Gene Transcription, Neutrophil extracellular trap formation - Mus musculus (mouse), Notch signaling pathway - Mus musculus (mouse), Notch-HLH transcription pathway, PIP3 activates AKT signaling, PTEN Regulation, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of MECP2 expression and activity, Regulation of PTEN gene transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, STAT3 nuclear events downstream of ALK signaling, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of chromatin organization proteins, Signal Transduction, Signaling by ALK, Signaling by Receptor Tyrosine Kinases, Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional Regulation by MECP2, Transcriptional Regulation by TP53, Transcriptional misregulation in cancer - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P70288
Entrez ID: 15182
|
Does Knockout of Trdmt1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Trdmt1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Trdmt1 (tRNA aspartic acid methyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, tRNA methylation, tRNA modification, tRNA processing, tRNA stabilization; MF: RNA binding, S-adenosylmethionine-dependent methyltransferase activity, catalytic activity, acting on a nucleic acid, methyltransferase activity, tRNA (cytidine-5-)-methyltransferase activity, tRNA methyltransferase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: O55055
Entrez ID: 13434
|
Does Knockout of Slc6a4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Slc6a4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, behavioral response to cocaine, brain morphogenesis, cellular response to cGMP, cellular response to retinoic acid, circadian rhythm, conditioned place preference, enteric nervous system development, male mating behavior, membrane depolarization, memory, monoamine transport, negative regulation of cerebellar granule cell precursor proliferation, negative regulation of neuron differentiation, negative regulation of organ growth, negative regulation of synaptic transmission, dopaminergic, neurotransmitter reuptake, neurotransmitter transport, platelet aggregation, positive regulation of cell cycle, positive regulation of gene expression, positive regulation of serotonin secretion, regulation of thalamus size, response to estradiol, response to hypoxia, response to nutrient, response to toxic substance, response to xenobiotic stimulus, serotonin transport, serotonin uptake, sodium ion transmembrane transport, vasoconstriction; MF: actin filament binding, antiporter activity, cocaine binding, identical protein binding, integrin binding, metal ion binding, monoamine transmembrane transporter activity, monoatomic cation channel activity, neurotransmitter transmembrane transporter activity, nitric-oxide synthase binding, protein binding, serotonin binding, serotonin:sodium:chloride symporter activity, sodium ion binding, syntaxin-1 binding; CC: anchoring junction, cell projection, endomembrane system, endosome, endosome membrane, focal adhesion, membrane, membrane raft, neuron projection, plasma membrane, postsynaptic membrane, presynaptic membrane, serotonergic synapse, synapse
Pathways: Neuronal System, Neurotransmitter clearance, SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Serotonergic synapse - Mus musculus (mouse), Serotonin clearance from the synaptic cleft, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules
UniProt: Q60857
Entrez ID: 15567
|
Does Knockout of Zfp119a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Zfp119a
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zfp119a (zinc finger protein 119a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q9JIC0
Entrez ID: 104349
|
Does Knockout of Pgr15l in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Pgr15l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pgr15l (G protein-coupled receptor 15-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity, peptide YY receptor activity; CC: cilium, membrane, non-motile cilium, plasma membrane
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse)
UniProt: Q80T54
Entrez ID: 245526
|
Does Knockout of Fdft1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Fdft1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fdft1 (farnesyl diphosphate farnesyl transferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, farnesyl diphosphate metabolic process, isoprenoid biosynthetic process, lipid biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: catalytic activity, metal ion binding, squalene synthase [NAD(P)H] activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: cytoplasmic side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, Steroid biosynthesis - Mus musculus (mouse), cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), epoxysqualene biosynthesis, superpathway of cholesterol biosynthesis
UniProt: P53798
Entrez ID: 14137
|
Does Knockout of Foxj1 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Foxj1
|
phagocytosis
|
macrophage
|
Gene: Foxj1 (forkhead box J1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, axoneme assembly, brain development, cell maturation, cell projection organization, central tolerance induction, ciliary basal body organization, cilium assembly, determination of left/right symmetry, epithelium development, establishment of apical/basal cell polarity, glomerular parietal epithelial cell development, heart development, humoral immune response, intracellular protein localization, left/right pattern formation, leukocyte migration, lung epithelium development, metanephric part of ureteric bud development, motile cilium assembly, negative regulation of B cell activation, negative regulation of T cell differentiation in thymus, negative regulation of T cell proliferation, negative regulation of germinal center formation, negative regulation of humoral immune response mediated by circulating immunoglobulin, negative regulation of interleukin-6 production, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of central B cell tolerance induction, positive regulation of lung ciliated cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of epithelial cell differentiation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: nucleus
Pathways:
UniProt: Q61660
Entrez ID: 15223
|
Does Knockout of Upf3a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Upf3a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Upf3a (UPF3 regulator of nonsense transcripts homolog A (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: in utero embryonic development, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of mRNA cis splicing, via spliceosome, positive regulation of translation, random inactivation of X chromosome, spermatogenesis; MF: RNA binding, mRNA binding, nucleic acid binding, protein sequestering activity, telomeric DNA binding; CC: cytoplasm, exon-exon junction complex, neuron projection, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q3ULJ3
Entrez ID: 67031
|
Does Knockout of Aspa in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Aspa
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Aspa (aspartoacylase)
Type: protein-coding
Summary: This gene encodes an enzyme that deacteylates N-acetyl-L-aspartic acid (NAA) in the brain to yield acetate and L-aspartate. In humans, alterations in neuronal NAA concentration are associated with many neurodegenerative diseases (decrease associated with epilepsy, multiple sclerosis, myotrophic lateral sclerosis, and Alzheimer's disease; increase associated with Canavan disease). In mouse, mutations in this gene, which cause accumulation of NAA, result in demyelination and spongy degeneration in the CNS and serve as a pathophysiological model for Canavan disease. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: acetate metabolic process, aspartate metabolic process, positive regulation of oligodendrocyte differentiation; MF: aminoacylase activity, aspartoacylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, hydrolase activity, acting on ester bonds, identical protein binding, metal ion binding, protein binding; CC: cytoplasm, cytosol, nucleus
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Aspartate and asparagine metabolism, Histidine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives
UniProt: Q8R3P0
Entrez ID: 11484
|
Does Knockout of Sox17 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Sox17
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Sox17 (SRY (sex determining region Y)-box 17)
Type: protein-coding
Summary: This gene encodes a member of the Sox (Sry-related high mobility group box) family of transcription factors involved in the regulation of embryonic development. The encoded protein plays a role in the determination of cell fate and in maintaining cell identity. This gene regulates tumor angiogenesis and tumor progression. Mutations in the human gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: Wnt signaling pathway, angiogenesis, cardiac cell fate determination, cardiogenic plate morphogenesis, cell migration involved in gastrulation, cellular response to leukemia inhibitory factor, common bile duct development, embryonic foregut morphogenesis, embryonic heart tube development, embryonic heart tube morphogenesis, embryonic organ development, endocardial cell differentiation, endocardium formation, endoderm development, endoderm formation, endodermal cell fate determination, endodermal cell fate specification, endodermal digestive tract morphogenesis, gallbladder development, gastrulation, heart development, heart looping, inner cell mass cellular morphogenesis, metanephros development, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, outflow tract morphogenesis, positive regulation of DNA-templated transcription, positive regulation of endodermal cell differentiation, positive regulation of gene expression, positive regulation of protein catabolic process, positive regulation of stem cell differentiation, positive regulation of transcription by RNA polymerase II, protein destabilization, protein stabilization, regulation of DNA-templated transcription, regulation of cardiac cell fate specification, regulation of cell differentiation, regulation of embryonic development, regulation of stem cell division, regulation of stem cell proliferation, regulation of transcription by RNA polymerase II, response to alkaloid, rostrocaudal neural tube patterning, signal transduction involved in regulation of gene expression, spermatogenesis, stem cell differentiation, stem cell fate specification, ureter development, vasculogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, beta-catenin binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: nucleoplasm, nucleus, transcription regulator complex
Pathways: Deactivation of the beta-catenin transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q61473
Entrez ID: 20671
|
Does Knockout of Ccdc157 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Ccdc157
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Ccdc157 (coiled-coil domain containing 157)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5SPX1
Entrez ID: 216516
|
Does Knockout of 1810024B03Rik in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
1810024B03Rik
|
response to bacteria
|
macrophage
|
Gene: 1810024B03Rik (RIKEN cDNA 1810024B03 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, negative regulation of glycogen biosynthetic process; MF: ATP binding, kinase activity, protein kinase activity, protein serine/threonine kinase activity; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8BWE1
Entrez ID: 329509
|
Does Knockout of L1cam in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
L1cam
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: L1cam (L1 cell adhesion molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, axon guidance, axonal fasciculation, cell adhesion, cell differentiation, cell migration, cell surface receptor signaling pathway, cell-cell adhesion mediated by integrin, cell-matrix adhesion, cerebellar neuron development, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, homotypic cell-cell adhesion, leukocyte cell-cell adhesion, maintenance of synapse structure, modulation of chemical synaptic transmission, nervous system development, neuron projection development, positive regulation of axon extension, positive regulation of calcium-mediated signaling, positive regulation of cell adhesion, positive regulation of cell-cell adhesion, positive regulation of cell-substrate adhesion, protein localization to plasma membrane raft, regulation of ERK1 and ERK2 cascade, regulation of neuron projection development, regulation of synapse assembly, response to toluene, synapse organization; MF: PDZ domain binding, axon guidance receptor activity, identical protein binding, integrin binding, protein binding, protein domain specific binding, sialic acid binding; CC: GABA-ergic synapse, Schaffer collateral - CA1 synapse, axon, axonal growth cone, cell projection, cell surface, dendrite, dendritic growth cone, endosome, external side of plasma membrane, glutamatergic synapse, growth cone, membrane, neuronal cell body, plasma membrane, presynaptic membrane, terminal bouton
Pathways: Axon guidance - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse)
UniProt: A2AFG8, Q6PGJ3, A2AFG7, B7ZCD3, F6UIL7, F7A5H7
Entrez ID: 16728
|
Does Knockout of 5031410I06Rik in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
5031410I06Rik
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: 5031410I06Rik (RIKEN cDNA 5031410I06 gene)
Type: protein-coding
Summary: RIKEN cDNA 5031410I06 gene
Gene Ontology:
Pathways:
UniProt: E9Q4E0
Entrez ID: 381622
|
Does Knockout of Cmya5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Cmya5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cmya5 (cardiomyopathy associated 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of calcineurin-NFAT signaling cascade, regulation of skeletal muscle adaptation; MF: identical protein binding, protein binding, protein phosphatase inhibitor activity; CC: M band, costamere, cytoplasm, nucleus, perinuclear region of cytoplasm, sarcoplasmic reticulum
Pathways:
UniProt: E9QLJ0
Entrez ID: 76469
|
Does Knockout of Rho in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Rho
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rho (rhodopsin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled opsin signaling pathway, G protein-coupled receptor signaling pathway, absorption of visible light, cellular response to light stimulus, detection of light stimulus, detection of temperature stimulus involved in thermoception, gene expression, microtubule cytoskeleton organization, photoreceptor cell maintenance, phototransduction, podosome assembly, red, far-red light phototransduction, response to light intensity, response to light stimulus, retina development in camera-type eye, rod bipolar cell differentiation, sensory perception of light stimulus, signal transduction, thermotaxis, visual perception; MF: 11-cis retinal binding, G protein-coupled photoreceptor activity, G protein-coupled receptor activity, metal ion binding, photoreceptor activity, protein binding, retinal binding, spectrin binding; CC: Golgi apparatus, cell projection, cell-cell junction, membrane, photoreceptor disc membrane, photoreceptor inner segment, photoreceptor inner segment membrane, photoreceptor outer segment, photoreceptor outer segment membrane, plasma membrane, rod photoreceptor outer segment, rough endoplasmic reticulum membrane, sperm head plasma membrane, sperm midpiece
Pathways: Activation of the phototransduction cascade, Cargo trafficking to the periciliary membrane, Cilium Assembly, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Inactivation, recovery and regulation of the phototransduction cascade, Opsins, Organelle biogenesis and maintenance, Phototransduction - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by GPCR, The canonical retinoid cycle in rods (twilight vision), The phototransduction cascade, Visual phototransduction, VxPx cargo-targeting to cilium
UniProt: P15409
Entrez ID: 212541
|
Does Knockout of Il18rap in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Il18rap
|
response to virus
|
Microglial Cell Line
|
Gene: Il18rap (interleukin 18 receptor accessory protein)
Type: protein-coding
Summary: Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and mediates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: adaptive immune response, cell population proliferation, cellular response to cytokine stimulus, cellular response to hydrogen peroxide, cellular response to interleukin-18, immune system process, inflammatory response, interleukin-18-mediated signaling pathway, neutrophil activation, positive regulation of NF-kappaB transcription factor activity, positive regulation of natural killer cell mediated cytotoxicity, signal transduction; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, coreceptor activity, hydrolase activity, interleukin-1 receptor activity, interleukin-18 receptor activity; CC: cell surface, interleukin-18 receptor complex, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-1 family signaling, Interleukin-18 signaling, Signaling by Interleukins, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q9Z2B1
Entrez ID: 16174
|
Does Knockout of Ube2v2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Ube2v2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ube2v2 (ubiquitin-conjugating enzyme E2 variant 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA double-strand break processing, error-free postreplication DNA repair, negative regulation of neuron apoptotic process, positive regulation of DNA repair, positive regulation of double-strand break repair, positive regulation of neuron projection development, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked ubiquitination, positive regulation of synapse assembly, postreplication repair, protein K63-linked ubiquitination; CC: UBC13-MMS2 complex, nucleoplasm, nucleus, ubiquitin conjugating enzyme complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cell Cycle, Cell Cycle Checkpoints, Class I MHC mediated antigen processing & presentation, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, E3 ubiquitin ligases ubiquitinate target proteins, Formation of Incision Complex in GG-NER, G2/M Checkpoints, G2/M DNA damage checkpoint, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Metabolism of proteins, Nonhomologous End-Joining (NHEJ), Nucleotide Excision Repair, Post-translational protein modification, Processing of DNA double-strand break ends, Protein ubiquitination, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q9D2M8
Entrez ID: 70620
|
Does Knockout of Gdpd2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Gdpd2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Gdpd2 (glycerophosphodiester phosphodiesterase domain containing 2)
Type: protein-coding
Summary: This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. Overexpression of this gene is associated with activity-dependent actin cytoskeleton disorganization. The encoded protein may negatively regulate growth rate and induce differentiation of osteoblasts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: actin filament organization, lipid metabolic process, positive regulation of cell differentiation, positive regulation of osteoblast differentiation; MF: glycerophosphodiester phosphodiesterase activity, glycerophosphoinositol inositolphosphodiesterase activity, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity; CC: actin filament, cytoplasm, cytoskeleton, lamellipodium, membrane, plasma membrane
Pathways:
UniProt: Q9ESM6
Entrez ID: 71584
|
Does Knockout of Crbn in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Crbn
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Crbn (cereblon)
Type: protein-coding
Summary: This gene encodes a protein with a Lon protease domain, a 'regulators of G protein-signaling' (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium channels in brain and to bind thalidomide. In humans mutation in this gene causes autosomal recessive nonsyndromic cognitive disability. In mouse deficiency of this gene serves as a model to study the molecular mechanisms governing learning and memory as they relate to intellectual disability. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: limb development, locomotory exploration behavior, negative regulation of large conductance calcium-activated potassium channel activity, negative regulation of monoatomic ion transmembrane transport, negative regulation of protein-containing complex assembly, positive regulation of Wnt signaling pathway, positive regulation of protein-containing complex assembly, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination; MF: metal ion binding, transmembrane transporter binding; CC: Cul4A-RING E3 ubiquitin ligase complex, cytoplasm, membrane, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q8C7D2
Entrez ID: 58799
|
Does Knockout of Rhox3f in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Rhox3f
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rhox3f (reproductive homeobox 3F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: A6H657, A2ANE1, V9GWT1, V9GXR2
Entrez ID: 621852
|
Does Knockout of Bcas2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Bcas2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Bcas2 (BCAS2 pre-mRNA processing factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, oocyte development, oogenesis, ovarian follicle development, protein catabolic process, spindle assembly; CC: DNA replication factor A complex, Prp19 complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, centrosome, nuclear speck, nucleolus, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9D287
Entrez ID: 68183
|
Does Knockout of Gpaa1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Gpaa1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gpaa1 (GPI anchor attachment protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, GPI anchored protein biosynthesis, attachment of GPI anchor to protein; MF: GPI anchor binding, GPI-anchor transamidase activity, metal ion binding; CC: GPI-anchor transamidase complex, centrosome, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, plasma membrane
Pathways: Attachment of GPI anchor to uPAR, Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q9WTK3
Entrez ID: 14731
|
Does Knockout of 2310009B15Rik in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
2310009B15Rik
|
phagocytosis
|
macrophage
|
Gene: 2310009B15Rik (RIKEN cDNA 2310009B15 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A0A6YWI4, D3Z1T2
Entrez ID: 69549
|
Does Knockout of Fcrla in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Fcrla
|
response to bacteria
|
renal medulla cell line
|
Gene: Fcrla (Fc receptor-like A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell surface receptor signaling pathway, immune response, regulation of immune response; MF: protein binding, transmembrane signaling receptor activity; CC: cytoplasm, external side of plasma membrane
Pathways:
UniProt: Q920A9
Entrez ID: 98752
|
Does Knockout of Gm3086 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,663
|
Knockout
|
Gm3086
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gm3086 (predicted gene 3086)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Brd3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Brd3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Brd3 (bromodomain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, endodermal cell differentiation, positive regulation of transcription by RNA polymerase II, protein localization to chromatin, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: histone H3K18cr reader activity, histone H3K27cr reader activity, histone H3K9cr reader activity, histone H3K9me2/3 reader activity, histone reader activity, lncRNA binding, molecular condensate scaffold activity; CC: chromatin, chromosome, nucleus
Pathways:
UniProt: Q8K2F0
Entrez ID: 67382
|
Does Knockout of Avpr1b in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Avpr1b
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Avpr1b (arginine vasopressin receptor 1B)
Type: protein-coding
Summary: Predicted to enable vasopressin receptor activity. Involved in regulation of blood pressure. Acts upstream of or within regulation of systemic arterial blood pressure by vasopressin. Predicted to be located in Golgi apparatus. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in autism spectrum disorder; bipolar disorder; and mood disorder. Orthologous to human AVPR1B (arginine vasopressin receptor 1B). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cellular response to hormone stimulus, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of arachidonate secretion, positive regulation of cellular pH reduction, positive regulation of cytosolic calcium ion concentration, positive regulation of glutamate secretion, positive regulation of inositol phosphate biosynthetic process, positive regulation of vasoconstriction, regulation of blood pressure, regulation of cell population proliferation, regulation of systemic arterial blood pressure by vasopressin, signal transduction, symbiont entry into host cell; MF: G protein-coupled receptor activity, identical protein binding, peptide hormone binding, vasopressin receptor activity; CC: Golgi apparatus, dendrite, membrane, plasma membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Phospholipase D signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Vascular smooth muscle contraction - Mus musculus (mouse), Vasopressin-like receptors
UniProt: Q9WU02
Entrez ID: 26361
|
Does Knockout of Cfap161 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Cfap161
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Cfap161 (cilia and flagella associated protein 161)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, flagellated sperm motility; CC: axonemal A tubule inner sheath, axonemal microtubule, cell projection, cilium, cytoplasm, cytoskeleton, motile cilium, sperm flagellum
Pathways:
UniProt: Q6P8Y0
Entrez ID: 75556
|
Does Knockout of Atxn7l1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Atxn7l1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Atxn7l1 (ataxin 7-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9CZ05
Entrez ID: 380753
|
Does Knockout of Kcnj8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Kcnj8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kcnj8 (potassium inwardly-rectifying channel, subfamily J, member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CAMKK-AMPK signaling cascade, NLRP3 inflammasome complex assembly, action potential, adaptive immune response, apoptotic process, atrioventricular node cell differentiation, blood vessel development, calcium ion transmembrane transport, cardiac pacemaker cell differentiation, cell population proliferation, circulatory system development, coronary vasculature development, defense response to virus, determination of adult lifespan, establishment of cell polarity, fat cell differentiation, fatty acid transport, fibroblast proliferation, gene expression, glutamate secretion, neurotransmission, heart development, heart morphogenesis, inflammatory response, inorganic cation transmembrane transport, kidney development, membrane repolarization during ventricular cardiac muscle cell action potential, microglial cell activation, monoatomic ion transmembrane transport, monoatomic ion transport, nervous system process, neuromuscular process, p38MAPK cascade, phloem or xylem histogenesis, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, protein secretion, reactive gliosis, regulation of blood pressure, regulation of heart rate, regulation of monoatomic ion transmembrane transport, regulation of presynaptic membrane potential, response to ATP, response to cytokine, response to endoplasmic reticulum stress, response to exogenous dsRNA, response to hypoxia, response to insulin, response to ischemia, response to lipopolysaccharide, response to resveratrol, response to stress, response to xenobiotic stimulus, synaptic assembly at neuromuscular junction, transmission of nerve impulse, vasculature development, vasodilation, ventricular cardiac muscle tissue development; MF: ATP binding, ATP-activated inward rectifier potassium channel activity, ATPase-coupled monoatomic cation transmembrane transporter activity, inward rectifier potassium channel activity, protein binding, sulfonylurea receptor binding, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; CC: glutamatergic synapse, inward rectifying potassium channel, membrane, monoatomic ion channel complex, myofibril, plasma membrane, presynapse, presynaptic active zone membrane, protein-containing complex, sarcolemma
Pathways: ATP sensitive Potassium channels, Inwardly rectifying K+ channels, Neuronal System, Potassium Channels, cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P97794
Entrez ID: 16523
|
Does Knockout of Scgb2a2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Scgb2a2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Scgb2a2 (secretoglobin, family 2A, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: J3KMP9
Entrez ID: 102639117
|
Does Knockout of Tfap2c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Tfap2c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tfap2c (transcription factor AP-2, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebral cortex development, dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis, epithelial cell differentiation, epithelial cell proliferation involved in mammary gland duct elongation, forebrain neuron fate commitment, germ-line stem cell population maintenance, hair follicle development, inner cell mass cell differentiation, keratinocyte development, male gonad development, morula formation, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of epidermis development, regulation of transcription by RNA polymerase II, sebaceous gland development, skin development, somatic stem cell population maintenance, stem cell differentiation, stem cell population maintenance, trophectodermal cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: mitochondrion, nucleoplasm, nucleus
Pathways: Activation of the TFAP2 (AP-2) family of transcription factors, Developmental Biology, Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Negative regulation of activity of TFAP2 (AP-2) family transcription factors, Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription factors, Specification of the neural plate border, TFAP2 (AP-2) family regulates transcription of cell cycle factors, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: Q61312
Entrez ID: 21420
|
Does Knockout of Ikzf5 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Ikzf5
|
cell proliferation
|
Regulatory T cell
|
Gene: Ikzf5 (IKAROS family zinc finger 5)
Type: protein-coding
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human IKZF5 (IKAROS family zinc finger 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, metal ion binding, protein domain specific binding, zinc ion binding; CC: nucleus, protein-containing complex
Pathways:
UniProt: Q8BU00
Entrez ID: 67143
|
Does Knockout of Samm50 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 163
|
Knockout
|
Samm50
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Samm50 (SAMM50 sorting and assembly machinery component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cristae formation, protein import into mitochondrial matrix, protein insertion into mitochondrial outer membrane; CC: SAM complex, cytoplasm, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion, outer membrane
Pathways: RAC2 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BGH2
Entrez ID: 68653
|
Does Knockout of Sftpc in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Sftpc
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sftpc (surfactant associated protein C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: alveolar lamellar body, cytoplasm, extracellular region, extracellular space, multivesicular body
Pathways:
UniProt: Q6P8P8
Entrez ID: 20389
|
Does Knockout of Tmem126a in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Tmem126a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmem126a (transmembrane protein 126A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial protein quality control, mitochondrial respiratory chain complex I assembly, optic nerve development, protein insertion into mitochondrial inner membrane from matrix, toll-like receptor 4 signaling pathway; CC: membrane, mitochondrial inner membrane, mitochondrion, plasma membrane
Pathways:
UniProt: Q9D8Y1
Entrez ID: 66271
|
Does Knockout of Tesk2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Tesk2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tesk2 (testis-specific kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, focal adhesion assembly, protein phosphorylation, spermatogenesis; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q8VCT9
Entrez ID: 230661
|
Does Knockout of Kcnk13 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Kcnk13
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Kcnk13 (potassium channel, subfamily K, member 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, regulation of NLRP3 inflammasome complex assembly, regulation of excitatory synapse pruning, regulation of resting membrane potential; MF: identical protein binding, metal ion binding, outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity, protein heterodimerization activity; CC: membrane, monoatomic ion channel complex, plasma membrane
Pathways: Cardiac conduction, Muscle contraction, Neuronal System, Phase 4 - resting membrane potential, Potassium Channels, Tandem pore domain halothane-inhibited K+ channel (THIK), Tandem pore domain potassium channels
UniProt: Q8R1P5
Entrez ID: 217826
|
Does Knockout of Usp3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Usp3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Usp3 (ubiquitin specific peptidase 3)
Type: protein-coding
Summary: The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. In addition, knock down of protein levels results in spontaneous tumor development and shortened lifespan, consistent with a function in preserving chromosomal integrity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, chromatin organization, negative regulation of transcription by RNA polymerase II, protein deubiquitination, proteolysis; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2A deubiquitinase activity, histone H2B deubiquitinase activity, histone binding, hydrolase activity, metal ion binding, peptidase activity, promoter-specific chromatin binding, zinc ion binding; CC: Flemming body, chromatin, cytoplasm, cytoplasmic ribonucleoprotein granule, nucleoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q91W36
Entrez ID: 235441
|
Does Knockout of Pdzrn4 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Pdzrn4
|
cell proliferation
|
Regulatory T cell
|
Gene: Pdzrn4 (PDZ domain containing RING finger 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways:
UniProt: B9EKP7, E9Q5P6, E9PUZ9, Q3UXJ7, Q69Z24
Entrez ID: 239618
|
Does Knockout of Cacng7 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Cacng7
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Cacng7 (calcium channel, voltage-dependent, gamma subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, neurotransmitter receptor localization to postsynaptic specialization membrane, positive regulation of dendrite extension, positive regulation of synaptic transmission, glutamatergic, postsynaptic neurotransmitter receptor diffusion trapping, regulation of AMPA receptor activity, regulation of mRNA stability, transmission of nerve impulse; MF: calcium channel activity, calcium channel regulator activity, channel regulator activity, voltage-gated calcium channel activity; CC: AMPA glutamate receptor complex, L-type voltage-gated calcium channel complex, cerebellar mossy fiber, early endosome, glutamatergic synapse, membrane, monoatomic ion channel complex, neuronal cell body, plasma membrane, postsynaptic density membrane, synapse
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Muscle contraction, Oxytocin signaling pathway - Mus musculus (mouse), Phase 0 - rapid depolarisation, Phase 2 - plateau phase
UniProt: P62956
Entrez ID: 81904
|
Does Knockout of Usp9x in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Usp9x
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Usp9x (ubiquitin specific peptidase 9, X chromosome)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, DNA alkylation repair, axon extension, cell division, cell migration, cellular response to transforming growth factor beta stimulus, cerebellar cortex structural organization, chromosome segregation, cilium assembly, cytosolic ciliogenesis, hippocampus development, in utero embryonic development, monoubiquitinated protein deubiquitination, negative regulation of cilium assembly, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, neuron migration, neuron projection extension, positive regulation of TORC2 signaling, positive regulation of protein binding, post-embryonic development, protein K63-linked deubiquitination, protein deubiquitination, protein deubiquitination involved in ubiquitin-dependent protein catabolic process, protein import into peroxisome matrix, protein import into peroxisome matrix, receptor recycling, protein stabilization, proteolysis, regulation of circadian rhythm, regulation of postsynapse assembly, regulation of protein stability, rhythmic process, transforming growth factor beta receptor signaling pathway; MF: K11-linked deubiquitinase activity, K48-linked deubiquitinase activity, K63-linked deubiquitinase activity, co-SMAD binding, cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, metal ion binding, molecular sequestering activity, peptidase activity, protein binding, ubiquitin protein ligase binding; CC: apical part of cell, cell projection, centrosome, cilium, cytoplasm, cytoskeleton, cytosol, growth cone, nucleus, postsynapse
Pathways: Deubiquitination, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Peroxisomal protein import, Post-translational protein modification, Protein localization, Protein ubiquitination, RHO GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, RNA Polymerase II Transcription, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Ub-specific processing proteases
UniProt: P70398
Entrez ID: 22284
|
Does Knockout of Gga2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Gga2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gga2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi to plasma membrane transport, intracellular protein transport, protein localization to cell surface, protein transport, vesicle-mediated transport; MF: phosphatidylinositol binding, protein binding, small GTPase binding, ubiquitin binding; CC: Golgi apparatus, clathrin-coated vesicle, early endosome membrane, endosome, endosome membrane, membrane, trans-Golgi network
Pathways: Lysosome - Mus musculus (mouse)
UniProt: Q6P5E6
Entrez ID: 74105
|
Does Knockout of Cyp2e1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Cyp2e1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 4-nitrophenol metabolic process, epoxygenase P450 pathway, fatty acid metabolic process, lipid hydroxylation, lipid metabolic process, long-chain fatty acid metabolic process, monoterpenoid metabolic process, response to bacterium, steroid metabolic process, triglyceride metabolic process, xenobiotic metabolic process; MF: 4-nitrophenol 2-monooxygenase activity, Hsp70 protein binding, Hsp90 protein binding, arachidonate epoxygenase activity, enzyme binding, heme binding, iron ion binding, long-chain fatty acid omega-1 hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Alcoholic liver disease - Mus musculus (mouse), Arachidonic acid metabolism - Mus musculus (mouse), Aspirin ADME, Biological oxidations, Biosynthesis of DHA-derived SPMs, Biosynthesis of maresin-like SPMs, Biosynthesis of maresins, Biosynthesis of specialized proresolving mediators (SPMs), CYP2E1 reactions, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Cytochrome P450 - arranged by substrate type, Drug ADME, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Paracetamol ADME, Phase I - Functionalization of compounds, Steroid hormone biosynthesis - Mus musculus (mouse), Xenobiotics, bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q05421
Entrez ID: 13106
|
Does Knockout of Tsga13 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Tsga13
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tsga13 (testis specific gene A13)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DA17
Entrez ID: 116732
|
Does Knockout of Rbp7 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Rbp7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rbp7 (retinol binding protein 7, cellular)
Type: protein-coding
Summary: Enables retinoid binding activity. Predicted to be involved in fatty acid transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including embryo mesenchyme; epididymal fat pad; musculature; respiratory system; and small intestine. Orthologous to human RBP7 (retinol binding protein 7). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: fatty acid binding, lipid binding, retinal binding, retinoid binding, retinol binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q9EPC5
Entrez ID: 63954
|
Does Knockout of Pnkp in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Pnkp
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Pnkp (polynucleotide kinase 3'- phosphatase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via nonhomologous end joining, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of telomere maintenance, protein K63-linked ubiquitination, response to oxidative stress; MF: ATP binding, ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity, ATP-dependent polynucleotide 5'-hydroxyl-kinase activity, catalytic activity, hydrolase activity, kinase activity, nucleotide binding, polynucleotide 3'-phosphatase activity, transferase activity, ubiquitin-like ligase-substrate adaptor activity; CC: SCF ubiquitin ligase complex, nucleolus, nucleoplasm, nucleus, site of double-strand break
Pathways:
UniProt: E9Q9A5, G5E8N7, A0A0J9YUT2, A0A0J9YVH5, A0A140LIZ1, A0A0J9YUF9, A0A0J9YTV1, D3YZV7, A0A0J9YV48, A0A0J9YVJ6, A0A140LJ53
Entrez ID: 59047
|
Does Knockout of Tmem219 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Tmem219
|
cell cycle progression
|
breast epithelium
|
Gene: Tmem219 (transmembrane protein 219)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, biological_process; CC: cellular_component, membrane, plasma membrane
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Death Receptors and Ligands, Transcriptional Regulation by TP53
UniProt: Q9D123
Entrez ID: 68742
|
Does Knockout of Gm9996 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Gm9996
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gm9996 (predicted gene 9996)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Rbx1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Rbx1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rbx1 (ring-box 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, G1/S transition of mitotic cell cycle, RNA polymerase II transcription initiation surveillance, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, T cell activation, TORC1 signaling, apoptotic process, autophagosome assembly, base-excision repair, AP site formation via deaminated base removal, cellular response to UV, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to insulin stimulus, cellular response to nutrient levels, cellular response to oxidative stress, epithelial to mesenchymal transition, insulin receptor signaling pathway, lysosome organization, miRNA-mediated gene silencing by mRNA destabilization, mitophagy, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of canonical NF-kappaB signal transduction, negative regulation of insulin receptor signaling pathway, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of response to oxidative stress, negative regulation of signal transduction by p53 class mediator, negative regulation of type I interferon production, negative regulation of ubiquitin-dependent protein catabolic process, p38MAPK cascade, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of epithelial cell apoptotic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein autoubiquitination, positive regulation of protein catabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of translation, positive regulation of type I interferon production, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein catabolic process, protein monoubiquitination, protein neddylation, protein polyubiquitination, protein ubiquitination, regulation of mitotic cell cycle, response to oxidative stress, signal transduction in response to DNA damage, spermatogenesis, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription-coupled nucleotide-excision repair, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: NEDD8 ligase activity, RNA polymerase II-specific DNA-binding transcription factor binding, cullin family protein binding, eukaryotic initiation factor 4E binding, metal ion binding, molecular adaptor activity, protein binding, protein-containing complex binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, Cul5-RING ubiquitin ligase complex, Cul7-RING ubiquitin ligase complex, SCF ubiquitin ligase complex, VCB complex, anaphase-promoting complex, cullin-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus, site of DNA damage, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian rhythm - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cytokine Signaling in Immune system, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Repair, DNA Replication, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Dual Incision in GG-NER, Dual incision in TC-NER, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, G1/S DNA Damage Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIF-1 signaling pathway - Mus musculus (mouse), Hedgehog 'off' state, Hedgehog 'on' state, Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, KEAP1-NFE2L2 pathway, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Metabolism of proteins, Mitotic G2-G2/M phases, Neddylation, Nuclear events mediated by NFE2L2, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Prolactin receptor signaling, Protein processing in endoplasmic reticulum - Mus musculus (mouse), RAF/MAP kinase cascade, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of BACH1 activity, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of T cell activation by CD28 family, Renal cell carcinoma - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SPOP-mediated proteasomal degradation of PD-L1(CD274), Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TGF-beta signaling pathway - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional regulation by RUNX2, Translation, Ubiquitin mediated proteolysis - Mus musculus (mouse), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Wnt signaling pathway - Mus musculus (mouse), p53-Independent G1/S DNA Damage Checkpoint
UniProt: P62878
Entrez ID: 56438
|
Does Knockout of Meltf in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Meltf
|
cell proliferation
|
Regulatory T cell
|
Gene: Meltf (melanotransferrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: iron ion transport, monoatomic ion transport, negative regulation of substrate adhesion-dependent cell spreading, positive regulation of extracellular matrix disassembly, positive regulation of plasminogen activation; MF: iron ion binding, metal ion binding; CC: cell surface, early endosome, extracellular region, extracellular space, membrane, plasma membrane, recycling endosome, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q9R0R1
Entrez ID: 30060
|
Does Knockout of Gpr3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Gpr3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gpr3 (G-protein coupled receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, positive regulation of cAMP/PKA signal transduction, positive regulation of cold-induced thermogenesis, regulation of cytosolic calcium ion concentration, regulation of meiotic nuclear division, signal transduction, sphingosine-1-phosphate receptor signaling pathway; MF: G protein-coupled receptor activity, sphingosine-1-phosphate receptor activity; CC: cytoplasm, membrane, plasma membrane
Pathways:
UniProt: P35413
Entrez ID: 14748
|
Does Knockout of Gla in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Gla
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Gla (galactosidase, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, carbohydrate metabolic process, glycoside catabolic process, glycosphingolipid catabolic process, glycosylceramide catabolic process, lipid metabolic process, lipid storage, negative regulation of nitric oxide biosynthetic process, negative regulation of nitric-oxide synthase activity, oligosaccharide metabolic process, platelet activation, platelet aggregation, regulation of axon diameter, regulation of locomotion involved in locomotory behavior, sleep; MF: alpha-galactosidase activity, catalytic activity, galactoside binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, protein homodimerization activity, signaling receptor binding; CC: Golgi apparatus, cytoplasm, extracellular region, extracellular space, lysosome, membrane
Pathways: Galactose metabolism - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Glycosphingolipid biosynthesis - globo and isoglobo series - Mus musculus (mouse), Lysosome - Mus musculus (mouse), Sphingolipid metabolism - Mus musculus (mouse), melibiose degradation
UniProt: P51569
Entrez ID: 11605
|
Does Knockout of Rsu1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Rsu1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rsu1 (Ras suppressor protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, positive regulation of cell-substrate adhesion, positive regulation of neural precursor cell proliferation, signal transduction
Pathways:
UniProt: A2AUR7, Q9D031, Q3TFN7, B1AYQ0, A0A0A6YWZ2, E0CXG5
Entrez ID: 20163
|
Does Knockout of Nr2f2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Nr2f2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Nr2f2 (nuclear receptor subfamily 2, group F, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, blood vessel morphogenesis, cell differentiation, female gonad development, fertilization, forebrain development, in utero embryonic development, interneuron migration, intracellular receptor signaling pathway, lymph vessel development, lymphatic endothelial cell fate commitment, maternal placenta development, negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, negative regulation of transcription by RNA polymerase II, negative regulation of vascular endothelial growth factor signaling pathway, nervous system development, neuron migration, placenta blood vessel development, positive regulation of DNA-templated transcription, positive regulation of systemic arterial blood pressure, positive regulation of transcription by RNA polymerase II, radial pattern formation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to estradiol, skeletal muscle tissue development, trophoblast giant cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, nuclear receptor activity, protein homodimerization activity, retinoic acid binding, sequence-specific DNA binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: P43135
Entrez ID: 11819
|
Does Knockout of Sh3rf2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Sh3rf2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sh3rf2 (SH3 domain containing ring finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of JNK cascade, negative regulation of apoptotic process, negative regulation of protein ubiquitination, positive regulation of JNK cascade, positive regulation of cell migration, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein autoubiquitination, protein ubiquitination, regulation of JNK cascade; MF: metal ion binding, phosphatase binding, protein phosphatase 1 binding, protein phosphatase inhibitor activity, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q8BZT2
Entrez ID: 269016
|
Does Knockout of Sh2d3c in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Sh2d3c
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Sh2d3c (SH2 domain containing 3C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, signal transduction, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, phosphotyrosine residue binding, protein binding, transmembrane receptor protein tyrosine kinase adaptor activity; CC: axon, cell projection, cytoplasm, cytosol, membrane, plasma membrane, ruffle membrane
Pathways:
UniProt: Q9QZS8
Entrez ID: 27387
|
Does Knockout of Filip1l in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Filip1l
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Filip1l (filamin A interacting protein 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, gene expression, hindgut development, intracellular protein localization, proteasomal protein catabolic process, protein localization to actin cytoskeleton, protein secretion; MF: molecular_function, protein binding; CC: actin cytoskeleton, cellular_component, centrosome, cytoplasm, membrane, nucleus
Pathways:
UniProt: Q6P6L0
Entrez ID: 78749
|
Does Knockout of Hsd17b12 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Hsd17b12
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen biosynthetic process, extracellular matrix organization, fatty acid biosynthetic process, fatty acid elongation, saturated fatty acid, lipid metabolic process, positive regulation of cell-substrate adhesion, steroid biosynthetic process; MF: collagen binding, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, fibronectin binding, heparin binding, oxidoreductase activity, very-long-chain 3-oxoacyl-CoA reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, extracellular matrix, fatty acid elongase complex, membrane
Pathways: Androgen biosynthesis, Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Steroid hormone biosynthesis - Mus musculus (mouse), Synthesis of very long-chain fatty acyl-CoAs, biosynthesis of estrogens
UniProt: O70503
Entrez ID: 56348
|
Does Knockout of Smpdl3b in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Smpdl3b
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Smpdl3b (sphingomyelin phosphodiesterase, acid-like 3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, inflammatory response, innate immune response, lipid catabolic process, lipid metabolic process, membrane lipid catabolic process, negative regulation of inflammatory response, negative regulation of innate immune response, negative regulation of toll-like receptor signaling pathway, sphingomyelin catabolic process; MF: hydrolase activity, hydrolase activity, acting on glycosyl bonds, metal ion binding, phosphoric diester hydrolase activity, protein binding, sphingomyelin phosphodiesterase activity, zinc ion binding; CC: extracellular region, extracellular space, membrane, plasma membrane, side of membrane
Pathways:
UniProt: P58242
Entrez ID: 100340
|
Does Knockout of Ahsa2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Ahsa2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ahsa2 (AHA1, activator of heat shock protein ATPase 2)
Type: protein-coding
Summary: Predicted to enable ATPase activator activity. Predicted to be involved in protein folding. Predicted to be active in cytosol. Is expressed in brain; cerebral cortex ventricular layer; and cortical plate. Orthologous to human AHSA2P (activator of HSP90 ATPase homolog 2, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: ATPase activator activity, protein-folding chaperone binding
Pathways:
UniProt: Q8N9S3
Entrez ID: 268390
|
Does Knockout of Dpp9 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Dpp9
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Dpp9 (dipeptidylpeptidase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CARD8 inflammasome complex assembly, NLRP1 inflammasome complex assembly, negative regulation of programmed cell death, protein maturation, proteolysis, pyroptotic cell death, pyroptotic inflammatory response; MF: aminopeptidase activity, dipeptidyl-peptidase activity, hydrolase activity, identical protein binding, peptidase activity, serine-type peptidase activity; CC: cell leading edge, cytoplasm, cytosol, microtubule
Pathways:
UniProt: Q8BVG4
Entrez ID: 224897
|
Does Knockout of Mogat2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Mogat2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mogat2 (monoacylglycerol O-acyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: diacylglycerol biosynthetic process, glycerol metabolic process, intestinal absorption, lipid metabolic process, monoacylglycerol biosynthetic process, monoacylglycerol metabolic process, triglyceride biosynthetic process; MF: 2-acylglycerol O-acyltransferase activity, O-acyltransferase activity, acetyltransferase activity, acyltransferase activity, diacylglycerol O-acyltransferase activity, transferase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, perinuclear endoplasmic reticulum membrane, perinuclear region of cytoplasm
Pathways: Fat digestion and absorption - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Triglyceride biosynthesis, Triglyceride metabolism
UniProt: Q80W94
Entrez ID: 233549
|
Does Knockout of S100a16 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
S100a16
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: S100a16 (S100 calcium binding protein A16)
Type: protein-coding
Summary: Enables calcium ion binding activity and identical protein binding activity. Acts upstream of or within response to calcium ion. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; gut; heart; nose; and urinary system. Orthologous to human S100A16 (S100 calcium binding protein A16). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: calcium ion binding, calcium-dependent protein binding, identical protein binding, metal ion binding, protein homodimerization activity; CC: cytoplasm, cytosol, extracellular space, nucleolus, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q9D708
Entrez ID: 67860
|
Does Knockout of Saraf in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Saraf
|
response to bacteria
|
renal medulla cell line
|
Gene: Saraf (store-operated calcium entry-associated regulatory factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transport, monoatomic ion transport, regulation of store-operated calcium entry; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, membrane
Pathways:
UniProt: Q8R3Q0
Entrez ID: 67887
|
Does Knockout of Pgpep1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Pgpep1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pgpep1 (pyroglutamyl-peptidase I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein catabolic process, proteolysis; MF: cysteine-type peptidase activity, hydrolase activity, peptidase activity, pyroglutamyl-peptidase activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q9ESW8
Entrez ID: 66522
|
Does Knockout of Slc30a9 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Slc30a9
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc30a9 (solute carrier family 30 (zinc transporter), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular zinc ion homeostasis, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transport, positive regulation of transcription by RNA polymerase II, regulation of mitochondrion organization, transmembrane transport, zinc ion transmembrane transport, zinc ion transport; MF: antiporter activity, chromatin binding, monoatomic cation transmembrane transporter activity, nuclear receptor binding, transcription coactivator activity, zinc ion transmembrane transporter activity; CC: cytoplasm, cytoplasmic vesicle, cytoskeleton, endoplasmic reticulum, membrane, mitochondrial membrane, mitochondrion, nucleus
Pathways:
UniProt: Q5IRJ6
Entrez ID: 109108
|
Does Knockout of Dmrt1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Dmrt1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Dmrt1 (doublesex and mab-3 related transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Sertoli cell development, Sertoli cell differentiation, cell differentiation, cell morphogenesis, developmental process involved in reproduction, germ cell migration, intracellular signal transduction, male germ cell proliferation, male gonad development, male sex determination, male sex differentiation, negative regulation of meiotic nuclear division, negative regulation of transcription by RNA polymerase II, oocyte development, positive regulation of male gonad development, positive regulation of meiosis I, positive regulation of mitotic nuclear division, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of nodal signaling pathway, regulation of transcription by RNA polymerase II, sex differentiation, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, female germ cell nucleus, nucleoplasm, nucleus
Pathways:
UniProt: Q9QZ59
Entrez ID: 50796
|
Does Knockout of Prkce in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Prkce
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prkce (protein kinase C, epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TRAM-dependent toll-like receptor 4 signaling pathway, cell adhesion, cell division, cellular response to ethanol, cellular response to hypoxia, cellular response to platelet-derived growth factor stimulus, cellular response to prostaglandin E stimulus, chemosensory behavior, establishment of localization in cell, immune system process, intracellular signal transduction, lipopolysaccharide-mediated signaling pathway, locomotory exploration behavior, macrophage activation involved in immune response, negative regulation of apoptotic process, negative regulation of mitochondrial calcium ion concentration, negative regulation of mitochondrial membrane potential, negative regulation of protein ubiquitination, negative regulation of release of sequestered calcium ion into cytosol, positive regulation of MAPK cascade, positive regulation of actin filament polymerization, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell-substrate adhesion, positive regulation of cytokinesis, positive regulation of epithelial cell migration, positive regulation of fibroblast migration, positive regulation of insulin secretion, positive regulation of lipid catabolic process, positive regulation of mucus secretion, positive regulation of synaptic transmission, GABAergic, positive regulation of wound healing, presynaptic modulation of chemical synaptic transmission, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of lipid metabolic process, regulation of release of sequestered calcium ion into cytosol, response to morphine, signal transduction, toxin catabolic process, xenobiotic catabolic process; MF: 14-3-3 protein binding, ATP binding, SH3 domain binding, actin monomer binding, diacylglycerol-dependent serine/threonine kinase activity, diacylglycerol-dependent, calcium-independent serine/threonine kinase activity, enzyme activator activity, enzyme binding, ethanol binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine kinase binding, signaling receptor activator activity, signaling receptor binding, transferase activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, T-tubule, cell periphery, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, glutamatergic synapse, intermediate filament cytoskeleton, membrane, mitochondrion, neuromuscular junction, nucleus, perinuclear region of cytoplasm, plasma membrane, presynaptic cytosol, synapse
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), DAG and IP3 signaling, Effects of PIP2 hydrolysis, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, G alpha (q) signalling events, GPCR downstream signalling, Hemostasis, Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Innate Immune System, Insulin resistance - Mus musculus (mouse), Intracellular signaling by second messengers, MicroRNAs in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Role of phospholipids in phagocytosis, SHC1 events in ERBB2 signaling, Signal Transduction, Signaling by ERBB2, Signaling by GPCR, Signaling by Receptor Tyrosine Kinases, Sphingolipid signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P16054
Entrez ID: 18754
|
Does Knockout of Pcdhac1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Pcdhac1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pcdhac1 (protocadherin alpha subfamily C, 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q91Y10
Entrez ID: 353236
|
Does Knockout of Ctsr in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Ctsr
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ctsr (cathepsin R)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: extracellular space, lysosome
Pathways:
UniProt: Q9JIA9
Entrez ID: 56835
|
Does Knockout of Amelx in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Amelx
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Amelx (amelogenin, X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amelogenesis, biomineral tissue development, cell adhesion, enamel mineralization, odontogenesis of dentin-containing tooth, regulation of cell population proliferation, response to calcium ion, response to nutrient, response to xenobiotic stimulus, signal transduction, tooth mineralization; MF: calcium ion binding, growth factor activity, hydroxyapatite binding, identical protein binding, protein binding, protein homodimerization activity, sodium ion binding, structural constituent of tooth enamel; CC: basement membrane, cell surface, endocytic vesicle, extracellular matrix, extracellular region, protein-containing complex, supramolecular complex
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: P63277
Entrez ID: 11704
|
Does Knockout of Rad54b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Rad54b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rad54b (RAD54 homolog B (S. cerevisiae))
Type: protein-coding
Summary: Predicted to enable DNA translocase activity. Acts upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Orthologous to human RAD54B (RAD54 homolog B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, determination of adult lifespan, double-strand break repair via homologous recombination, homologous recombination, reciprocal meiotic recombination, response to ionizing radiation, response to xenobiotic stimulus; MF: ATP binding, ATP-dependent activity, acting on DNA, DNA binding, DNA translocase activity, helicase activity, hydrolase activity, nucleotide binding; CC: nucleoplasm, nucleus
Pathways: Homologous recombination - Mus musculus (mouse)
UniProt: Q6PFE3
Entrez ID: 623474
|
Does Knockout of Mcam in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Mcam
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mcam (melanoma cell adhesion molecule)
Type: protein-coding
Summary: Predicted to enable laminin receptor activity. Predicted to be involved in angiogenesis and positive regulation of cell migration. Predicted to act upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in external side of plasma membrane and extracellular space. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; extraembryonic component; genitourinary system; gut; and nervous system. Orthologous to human MCAM (melanoma cell adhesion molecule). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: angiogenesis, cell adhesion, glomerular filtration, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, positive regulation of cell migration, vascular wound healing; CC: external side of plasma membrane, extracellular space, membrane, plasma membrane
Pathways: RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8R2Y2
Entrez ID: 84004
|
Does Knockout of Pcnx2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Pcnx2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Pcnx2 (pecanex homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q5DU28
Entrez ID: 270109
|
Does Knockout of Vmn2r67 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Vmn2r67
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vmn2r67 (vomeronasal 2, receptor 67)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2WCR5, K7N6T2, A0A3B2WDB7, A0A3B2WDB2
Entrez ID: 620672
|
Does Knockout of Parl in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Parl
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Parl (presenilin associated, rhomboid-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: membrane protein proteolysis, mitochondrial fusion, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of release of cytochrome c from mitochondria, protein processing, proteolysis, regulation of mitochondrion organization, regulation of mitophagy, regulation of protein targeting to mitochondrion, regulation of proteolysis, regulation of reactive oxygen species metabolic process, signal peptide processing; MF: endopeptidase activity, hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleus
Pathways: Mitochondrial calcium ion transport, Processing of SMDT1, Transport of small molecules
UniProt: Q5XJY4
Entrez ID: 381038
|
Does Knockout of Ankdd1b in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Ankdd1b
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Ankdd1b (ankyrin repeat and death domain containing 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, signal transduction
Pathways:
UniProt: Q14DN9
Entrez ID: 271144
|
Does Knockout of Gm21379 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Gm21379
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gm21379 (predicted gene, 21379)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9D3U4
Entrez ID: 100861987
|
Does Knockout of Krtap2-4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Krtap2-4
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Krtap2-4 (keratin associated protein 2-4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q9D3H4
Entrez ID: 71453
|
Does Knockout of E2f1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
E2f1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: E2f1 (E2F transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA-templated transcription, anoikis, apoptotic process, cellular response to fatty acid, cellular response to hypoxia, cellular response to nerve growth factor stimulus, cellular response to xenobiotic stimulus, forebrain development, intrinsic apoptotic signaling pathway by p53 class mediator, intrinsic apoptotic signaling pathway in response to DNA damage, lens fiber cell apoptotic process, mRNA stabilization, negative regulation of DNA-templated transcription, negative regulation of fat cell differentiation, negative regulation of fat cell proliferation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of glial cell proliferation, positive regulation of transcription by RNA polymerase II, quinolinate biosynthetic process, regulation of DNA-templated transcription, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, regulation of transcription by RNA polymerase II, response to lipopolysaccharide, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, molecular adaptor activity, protein binding, protein dimerization activity, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: RNA polymerase II transcription regulator complex, Rb-E2F complex, centrosome, chromatin, cytoplasm, nuclear chromosome, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cyclin D associated events in G1, Epstein-Barr virus infection - Mus musculus (mouse), G1 Phase, G2 Phase, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Non-small cell lung cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse)
UniProt: Q61501
Entrez ID: 13555
|
Does Knockout of Esp24 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Esp24
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Esp24 (exocrine gland secreted peptide 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, signal transduction; MF: pheromone activity; CC: extracellular space
Pathways:
UniProt: A8R0V6
Entrez ID: 100126776
|
Does Knockout of Phlpp1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Phlpp1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, entrainment of circadian clock, intracellular signal transduction, negative regulation of intracellular signal transduction, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of JNK cascade, regulation of MAPK cascade, regulation of T cell anergy, regulation of apoptotic process, regulation of p38MAPK cascade; MF: hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cytoplasm, membrane, nuclear membrane, nucleoplasm, nucleus, plasma membrane
Pathways: Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, PI3K-Akt signaling pathway - Mus musculus (mouse), PIP3 activates AKT signaling, Signal Transduction
UniProt: Q8CHE4
Entrez ID: 98432
|
Does Knockout of Tapbp in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Tapbp
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tapbp (TAP binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MHC class Ib protein complex assembly, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, antigen processing and presentation of peptide antigen via MHC class I, defense response, peptide antigen assembly with MHC class I protein complex, peptide antigen stabilization, protein-containing complex assembly, regulation of gene expression, regulation of protein complex stability; MF: MHC class I protein complex binding, TAP complex binding, TAP1 binding, TAP2 binding, molecular adaptor activity, peptide antigen binding, protein binding, protein folding chaperone; CC: Golgi membrane, MHC class I peptide loading complex, Tapasin-ERp57 complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, phagocytic vesicle membrane, plasma membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, ER-Phagosome pathway, Epstein-Barr virus infection - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System
UniProt: Q9R233
Entrez ID: 21356
|
Does Knockout of Ercc2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Ercc2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, UV protection, apoptotic process, bone mineralization, central nervous system myelin formation, chromosome segregation, determination of adult lifespan, embryonic cleavage, embryonic organ development, erythrocyte maturation, extracellular matrix organization, hair cell differentiation, hair cycle process, hair follicle maturation, hematopoietic stem cell differentiation, hematopoietic stem cell proliferation, in utero embryonic development, insulin-like growth factor receptor signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), multicellular organism growth, nucleobase-containing compound metabolic process, nucleotide-excision repair, positive regulation of mitotic recombination, post-embryonic development, regulation of mitotic cell cycle phase transition, regulation of transcription by RNA polymerase II, response to UV, response to hypoxia, response to oxidative stress, ribosomal small subunit biogenesis, skin development, spinal cord development, transcription by RNA polymerase II, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase II promoter, transcription-coupled nucleotide-excision repair; MF: 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, damaged DNA binding, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, iron-sulfur cluster binding, isomerase activity, metal ion binding, nucleic acid binding, nucleotide binding, protein-macromolecule adaptor activity; CC: CAK-ERCC2 complex, MMXD complex, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, spindle, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Mus musculus (mouse), DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, mRNA Capping
UniProt: O08811
Entrez ID: 13871
|
Does Knockout of Nsun5 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Nsun5
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Nsun5 (NOL1/NOP2/Sun domain family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, cerebral cortex development, cognition, corpus callosum development, methylation, oligodendrocyte development, positive regulation of translation, rRNA base methylation, rRNA processing, regulation of myelination; MF: RNA binding, RNA methyltransferase activity, methyltransferase activity, rRNA (cytosine-C5-)-methyltransferase activity, transferase activity; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8K4F6
Entrez ID: 100609
|
Does Knockout of Rab5a in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 1,522
|
Knockout
|
Rab5a
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Rab5a (RAB5A, member RAS oncogene family)
Type: protein-coding
Summary: Enables GTPase activity and guanyl nucleotide binding activity. Acts upstream of or within endocytosis. Located in several cellular components, including cytoplasmic vesicle; membrane raft; and ruffle. Is expressed in several structures, including 1-cell stage embryo; brain; cardiovascular system; genitourinary system; and gut. Orthologous to human RAB5A (RAB5A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: amyloid-beta clearance by transcytosis, canonical Wnt signaling pathway, early endosome to late endosome transport, endocytosis, endosomal transport, host-mediated perturbation of viral process, intracellular protein transport, membrane fusion, phagocytosis, plasma membrane to endosome transport, positive regulation of exocytosis, protein localization to early endosome, protein transport, receptor internalization, regulation of endosome size, regulation of filopodium assembly, regulation of long-term neuronal synaptic plasticity, regulation of synaptic vesicle exocytosis, synaptic vesicle recycling; MF: G protein activity, GDP binding, GDP-dissociation inhibitor binding, GTP binding, GTPase activity, guanyl nucleotide binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: actin cytoskeleton, axon, axon terminus, cell projection, cytoplasm, cytoplasmic side of early endosome membrane, cytoplasmic vesicle, cytosol, dendrite, early endosome, early endosome membrane, early phagosome, endocytic vesicle, endomembrane system, endosome, endosome membrane, glutamatergic synapse, melanosome, membrane, membrane raft, neuronal cell body, nucleoplasm, perinuclear region of cytoplasm, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, postsynaptic endocytic zone membrane, presynaptic endosome, protein-containing complex, recycling endosome, ruffle, somatodendritic compartment, synaptic vesicle, synaptic vesicle membrane, terminal bouton, zymogen granule membrane
Pathways: Amoebiasis - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Clathrin-mediated endocytosis, Endocytosis - Mus musculus (mouse), Factors involved in megakaryocyte development and platelet production, Hemostasis, Membrane Trafficking, Metabolism, Metabolism of lipids, Metabolism of proteins, PI Metabolism, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Phospholipid metabolism, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Ras signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Synthesis of PIPs at the plasma membrane, Tuberculosis - Mus musculus (mouse), Vasopressin-regulated water reabsorption - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q9CQD1
Entrez ID: 271457
|
Does Knockout of Slc7a6os in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Slc7a6os
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Slc7a6os (solute carrier family 7, member 6 opposite strand)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: developmental process, hematopoietic progenitor cell differentiation, protein transport; CC: cellular_component, cytoplasm, nucleus
Pathways:
UniProt: Q7TPE5
Entrez ID: 66432
|
Does Knockout of Vps53 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Vps53
|
response to bacteria
|
renal medulla cell line
|
Gene: Vps53 (VPS53 GARP complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytosolic transport, endocytic recycling, lysosomal transport, protein targeting to lysosome, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated cholesterol transport, vesicle-mediated transport; CC: EARP complex, GARP complex, Golgi apparatus, cytosol, endosome, endosome membrane, membrane, perinuclear region of cytoplasm, recycling endosome, trans-Golgi network
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q8CCB4
Entrez ID: 68299
|
Does Knockout of Ppp2r5a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Ppp2r5a
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ppp2r5a (protein phosphatase 2, regulatory subunit B', alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of protein localization to plasma membrane, signal transduction; MF: kinase binding, kinase inhibitor activity, protein binding, protein phosphatase activator activity, protein phosphatase regulator activity; CC: M band, Z disc, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytosol, nucleus, plasma membrane, protein phosphatase type 2A complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Antiviral mechanism by IFN-stimulated genes, Beta-catenin phosphorylation cascade, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Co-inhibition by CTLA4, Co-stimulation by CD28, Cytokine Signaling in Immune system, Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Dopaminergic synapse - Mus musculus (mouse), EML4 and NUDC in mitotic spindle formation, Hemostasis, Human papillomavirus infection - Mus musculus (mouse), Immune System, Interferon Signaling, Intracellular signaling by second messengers, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Negative regulation of MAPK pathway, Negative regulation of the PI3K/AKT network, Oocyte meiosis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PKR-mediated signaling, Platelet homeostasis, Platelet sensitization by LDL, RAF activation, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of T cell activation by CD28 family, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Sphingolipid signaling pathway - Mus musculus (mouse), TCF dependent signaling in response to WNT, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q6PD03
Entrez ID: 226849
|
Does Knockout of Dnajc21 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Dnajc21
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dnajc21 (DnaJ heat shock protein family (Hsp40) member C21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, nucleic acid binding, zinc ion binding; CC: cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt: E9Q8D0
Entrez ID: 78244
|
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