prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Rabac1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Rabac1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Rabac1 (Rab acceptor 1 (prenylated))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTPase binding, identical protein binding, proline-rich region binding, protein binding; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, glutamatergic synapse, membrane, plasma... |
Does Knockout of Slpi in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Slpi | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Slpi (secretory leukocyte peptidase inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, defense response to bacterium, host-mediated perturbation of symbiont process, immune response, immune system process, innate immune respon... |
Does Knockout of Thpo in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Thpo | protein/peptide accumulation | Melanoma Cell Line | Gene: Thpo (thrombopoietin)
Type: protein-coding
Summary: This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative spli... |
Does Knockout of Zfp882 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Zfp882 | cell proliferation | Mouse kidney carcinoma cell | Gene: Zfp882 (zinc finger protein 882)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA ... |
Does Knockout of Atp6v1c1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Atp6v1c1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Atp6v1c1 (ATPase, H+ transporting, lysosomal V1 subunit C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: proton transmembrane transporter activity, proton-transpor... |
Does Knockout of C5ar1 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | C5ar1 | protein/peptide accumulation | Melanoma Cell Line | Gene: C5ar1 (complement component 5a receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, amyloid-beta clearance, astrocyte activation, cell pro... |
Does Knockout of Acox1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Acox1 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Acox1 (acyl-Coenzyme A oxidase 1, palmitoyl)
Type: protein-coding
Summary: This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-co... |
Does Knockout of Ttc1 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Ttc1 | cell cycle progression | breast epithelium | Gene: Ttc1 (tetratricopeptide repeat domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, inflammatory response, positive regulation of inflammatory response, positive regulation of neuroinflammatory response; MF: molecular_function, protein-macro... |
Does Knockout of Hdac2 in Lung Cancer Cell Line causally result in tumorigenicity? | 0 | 1,781 | Knockout | Hdac2 | tumorigenicity | Lung Cancer Cell Line | Gene: Hdac2 (histone deacetylase 2)
Type: protein-coding
Summary: Enables several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, includ... |
Does Knockout of Trdmt1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Trdmt1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Trdmt1 (tRNA aspartic acid methyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, tRNA methylation, tRNA modification, tRNA processing, tRNA stabilization; MF: RNA binding, S-adenosylmethionine-dependent methyltransferase activity, catalyt... |
Does Knockout of Slc6a4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Slc6a4 | protein/peptide distribution | myoblast cell line | Gene: Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, behavioral response to cocaine, brain morphogenesis, cellular response to cGMP, cellular response to retinoic a... |
Does Knockout of Zfp119a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Zfp119a | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Zfp119a (zinc finger protein 119a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RN... |
Does Knockout of Pgr15l in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Pgr15l | protein/peptide distribution | myoblast cell line | Gene: Pgr15l (G protein-coupled receptor 15-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity, ... |
Does Knockout of Fdft1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Fdft1 | cell proliferation | Colonic Cancer Cell Line | Gene: Fdft1 (farnesyl diphosphate farnesyl transferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, f... |
Does Knockout of Foxj1 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Foxj1 | phagocytosis | macrophage | Gene: Foxj1 (forkhead box J1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, axoneme assembly, brain development, cell maturation, cell projection organization, central tolerance induction, ciliary basal body organization, cilium assembly... |
Does Knockout of Upf3a in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Upf3a | cell proliferation | Mouse kidney carcinoma cell | Gene: Upf3a (UPF3 regulator of nonsense transcripts homolog A (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: in utero embryonic development, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA cata... |
Does Knockout of Aspa in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Aspa | response to chemicals | Pancreatic Cancer Cell Line | Gene: Aspa (aspartoacylase)
Type: protein-coding
Summary: This gene encodes an enzyme that deacteylates N-acetyl-L-aspartic acid (NAA) in the brain to yield acetate and L-aspartate. In humans, alterations in neuronal NAA concentration are associated with many neurodegenerative diseases (decrease associa... |
Does Knockout of Sox17 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Sox17 | cell viability | Immortal mouse chromaffin cells | Gene: Sox17 (SRY (sex determining region Y)-box 17)
Type: protein-coding
Summary: This gene encodes a member of the Sox (Sry-related high mobility group box) family of transcription factors involved in the regulation of embryonic development. The encoded protein plays a role in the determination of cell... |
Does Knockout of Ccdc157 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Ccdc157 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Ccdc157 (coiled-coil domain containing 157)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5SPX1
Entrez ID: 216516 |
Does Knockout of 1810024B03Rik in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | 1810024B03Rik | response to bacteria | macrophage | Gene: 1810024B03Rik (RIKEN cDNA 1810024B03 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, negative regulation of glycogen biosynthetic process; MF: ATP binding, kinase activity, protein kinase activity, protein serine/threonine ki... |
Does Knockout of L1cam in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | L1cam | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: L1cam (L1 cell adhesion molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, axon guidance, axonal fasciculation, cell adhesion, cell differentiation, cell migration, cell surface receptor signaling pathway, cell-cell adhesion mediated by inte... |
Does Knockout of 5031410I06Rik in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | 5031410I06Rik | protein/peptide distribution | Microglial Cell Line | Gene: 5031410I06Rik (RIKEN cDNA 5031410I06 gene)
Type: protein-coding
Summary: RIKEN cDNA 5031410I06 gene
Gene Ontology:
Pathways:
UniProt: E9Q4E0
Entrez ID: 381622 |
Does Knockout of Cmya5 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Cmya5 | protein/peptide distribution | myoblast cell line | Gene: Cmya5 (cardiomyopathy associated 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of calcineurin-NFAT signaling cascade, regulation of skeletal muscle adaptation; MF: identical protein binding, protein binding, protein phosphatase inhibitor act... |
Does Knockout of Rho in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Rho | cell proliferation | Mouse kidney carcinoma cell | Gene: Rho (rhodopsin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled opsin signaling pathway, G protein-coupled receptor signaling pathway, absorption of visible light, cellular response to light stimulus, detection of light stimulus, detection of tempe... |
Does Knockout of Il18rap in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Il18rap | response to virus | Microglial Cell Line | Gene: Il18rap (interleukin 18 receptor accessory protein)
Type: protein-coding
Summary: Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. T... |
Does Knockout of Ube2v2 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Ube2v2 | protein/peptide distribution | myoblast cell line | Gene: Ube2v2 (ubiquitin-conjugating enzyme E2 variant 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA double-strand break processing, error-free postreplication DNA repair, negative regulation of neuron apoptotic process, positive regulation of DNA repair, positive... |
Does Knockout of Gdpd2 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Gdpd2 | protein/peptide distribution | Microglial Cell Line | Gene: Gdpd2 (glycerophosphodiester phosphodiesterase domain containing 2)
Type: protein-coding
Summary: This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. Overexpress... |
Does Knockout of Crbn in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Crbn | protein/peptide accumulation | Microglial Cell Line | Gene: Crbn (cereblon)
Type: protein-coding
Summary: This gene encodes a protein with a Lon protease domain, a 'regulators of G protein-signaling' (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium ... |
Does Knockout of Rhox3f in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Rhox3f | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Rhox3f (reproductive homeobox 3F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator ac... |
Does Knockout of Bcas2 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Bcas2 | protein/peptide distribution | myoblast cell line | Gene: Bcas2 (BCAS2 pre-mRNA processing factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, oocyte development, oogenesis, ovarian follicle development, protein c... |
Does Knockout of Gpaa1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Gpaa1 | protein/peptide distribution | myoblast cell line | Gene: Gpaa1 (GPI anchor attachment protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, GPI anchored protein biosynthesis, attachment of GPI anchor to protein; MF: GPI anchor binding, GPI-anchor transamidase activity, metal ion bindi... |
Does Knockout of 2310009B15Rik in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | 2310009B15Rik | phagocytosis | macrophage | Gene: 2310009B15Rik (RIKEN cDNA 2310009B15 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A0A6YWI4, D3Z1T2
Entrez ID: 69549 |
Does Knockout of Fcrla in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Fcrla | response to bacteria | renal medulla cell line | Gene: Fcrla (Fc receptor-like A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell surface receptor signaling pathway, immune response, regulation of immune response; MF: protein binding, transmembrane signaling receptor activity; CC: cytoplasm, e... |
Does Knockout of Gm3086 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,663 | Knockout | Gm3086 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Gm3086 (predicted gene 3086)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Brd3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Brd3 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Brd3 (bromodomain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, endodermal cell differentiation, positive regulation of transcription by RNA polymerase II, protein localization to chromatin, regulation of... |
Does Knockout of Avpr1b in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Avpr1b | protein/peptide accumulation | Melanoma Cell Line | Gene: Avpr1b (arginine vasopressin receptor 1B)
Type: protein-coding
Summary: Predicted to enable vasopressin receptor activity. Involved in regulation of blood pressure. Acts upstream of or within regulation of systemic arterial blood pressure by vasopressin. Predicted to be located in Golgi apparatus.... |
Does Knockout of Cfap161 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Cfap161 | protein/peptide accumulation | Microglial Cell Line | Gene: Cfap161 (cilia and flagella associated protein 161)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, flagellated sperm motility; CC: axonemal A tubule inner sheath, axonemal microtubule, cell projection, cilium, cytoplasm, cytoskeleton, motile cilium... |
Does Knockout of Atxn7l1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 163 | Knockout | Atxn7l1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Atxn7l1 (ataxin 7-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9CZ05
Entrez ID: 380753 |
Does Knockout of Kcnj8 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Kcnj8 | cell proliferation | Mouse kidney carcinoma cell | Gene: Kcnj8 (potassium inwardly-rectifying channel, subfamily J, member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CAMKK-AMPK signaling cascade, NLRP3 inflammasome complex assembly, action potential, adaptive immune response, apoptotic process, atrioventricular no... |
Does Knockout of Scgb2a2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Scgb2a2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Scgb2a2 (secretoglobin, family 2A, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: J3KMP9
Entrez ID: 102639117 |
Does Knockout of Tfap2c in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Tfap2c | cell proliferation | Mouse kidney carcinoma cell | Gene: Tfap2c (transcription factor AP-2, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebral cortex development, dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis, epithelial cell differentiation, epithelial cell proliferat... |
Does Knockout of Ikzf5 in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Ikzf5 | cell proliferation | Regulatory T cell | Gene: Ikzf5 (IKAROS family zinc finger 5)
Type: protein-coding
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity... |
Does Knockout of Samm50 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 163 | Knockout | Samm50 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Samm50 (SAMM50 sorting and assembly machinery component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cristae formation, protein import into mitochondrial matrix, protein insertion into mitochondrial outer membrane; CC: SAM complex, cytoplasm, membrane, mitochond... |
Does Knockout of Sftpc in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Sftpc | cell proliferation | Colonic Cancer Cell Line | Gene: Sftpc (surfactant associated protein C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: alveolar lamellar body, cytoplasm, extracellular region, extracellular space, multivesicular body
Pathways:
UniProt: Q6P8P8
Entrez ID: 20389 |
Does Knockout of Tmem126a in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Tmem126a | cell proliferation | Embryonic Stem Cell Line | Gene: Tmem126a (transmembrane protein 126A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial protein quality control, mitochondrial respiratory chain complex I assembly, optic nerve development, protein insertion into mitochondrial inner membrane from matrix,... |
Does Knockout of Tesk2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Tesk2 | cell proliferation | Colonic Cancer Cell Line | Gene: Tesk2 (testis-specific kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, focal adhesion assembly, protein phosphorylation, spermatogenesis; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kina... |
Does Knockout of Kcnk13 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,174 | Knockout | Kcnk13 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Kcnk13 (potassium channel, subfamily K, member 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, regulation of NLRP3 inflammasome comp... |
Does Knockout of Usp3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Usp3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Usp3 (ubiquitin specific peptidase 3)
Type: protein-coding
Summary: The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, ... |
Does Knockout of Pdzrn4 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Pdzrn4 | cell proliferation | Regulatory T cell | Gene: Pdzrn4 (PDZ domain containing RING finger 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways:
UniProt: B9EKP7, E9Q5P6, E9PUZ9, Q3UXJ7, Q69Z24
Entrez ID: 239618 |
Does Knockout of Cacng7 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Cacng7 | protein/peptide accumulation | Mouse cell | Gene: Cacng7 (calcium channel, voltage-dependent, gamma subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, neurotransmitter receptor local... |
Does Knockout of Usp9x in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Usp9x | protein/peptide accumulation | Microglial Cell Line | Gene: Usp9x (ubiquitin specific peptidase 9, X chromosome)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, DNA alkylation repair, axon extension, cell division, cell migration, cellular response to transforming growth factor beta stimulus, cerebella... |
Does Knockout of Gga2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Gga2 | cell proliferation | Melanoma Cell Line | Gene: Gga2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi to plasma membrane transport, intracellular protein transport, protein localization to cell... |
Does Knockout of Cyp2e1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Cyp2e1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 4-nitrophenol metabolic process, epoxygenase P450 pathway, fatty acid metabolic process, lipid hydroxylation, lipid metabolic process, long-chain fatty aci... |
Does Knockout of Tsga13 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Tsga13 | cell proliferation | Mouse kidney carcinoma cell | Gene: Tsga13 (testis specific gene A13)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DA17
Entrez ID: 116732 |
Does Knockout of Rbp7 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Rbp7 | cell proliferation | Melanoma Cell Line | Gene: Rbp7 (retinol binding protein 7, cellular)
Type: protein-coding
Summary: Enables retinoid binding activity. Predicted to be involved in fatty acid transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including embryo me... |
Does Knockout of Pnkp in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 1 | 345 | Knockout | Pnkp | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Pnkp (polynucleotide kinase 3'- phosphatase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via nonhomologous end joining, positive regulation of double-strand break repair via nonhomologous end joining, p... |
Does Knockout of Tmem219 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Tmem219 | cell cycle progression | breast epithelium | Gene: Tmem219 (transmembrane protein 219)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, biological_process; CC: cellular_component, membrane, plasma membrane
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polyme... |
Does Knockout of Gm9996 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Gm9996 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Gm9996 (predicted gene 9996)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Rbx1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Rbx1 | protein/peptide distribution | myoblast cell line | Gene: Rbx1 (ring-box 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, G1/S transition of mitotic cell cycle, RNA polymerase II transcription initiation surveillance, SCF-dep... |
Does Knockout of Meltf in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Meltf | cell proliferation | Regulatory T cell | Gene: Meltf (melanotransferrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: iron ion transport, monoatomic ion transport, negative regulation of substrate adhesion-dependent cell spreading, positive regulation of extracellular matrix disassembly, positive regulation o... |
Does Knockout of Gpr3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,308 | Knockout | Gpr3 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Gpr3 (G-protein coupled receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, positive regulation of cAMP/PKA signal transduction, positive... |
Does Knockout of Gla in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,177 | Knockout | Gla | tumorigenicity | Colonic Cancer Cell Line | Gene: Gla (galactosidase, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, carbohydrate metabolic process, glycoside catabolic process, glycosphingolipid catabolic process, glycosylceramide catabolic process, lipid metabolic process, lipid storage... |
Does Knockout of Rsu1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Rsu1 | protein/peptide distribution | myoblast cell line | Gene: Rsu1 (Ras suppressor protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, positive regulation of cell-substrate adhesion, positive regulation of neural precursor cell proliferation, signal transduction
Pathways:
... |
Does Knockout of Nr2f2 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Nr2f2 | response to virus | Neuroblastoma Cell Line | Gene: Nr2f2 (nuclear receptor subfamily 2, group F, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, blood vessel morphogenesis, cell differentiation, female gonad development, fertilization, forebrain development, in ute... |
Does Knockout of Sh3rf2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Sh3rf2 | cell proliferation | Melanoma Cell Line | Gene: Sh3rf2 (SH3 domain containing ring finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of JNK cascade, negative regulation of apoptotic process, negative regulation of protein ubiquitination, positive regulation of JNK cascade, positive reg... |
Does Knockout of Sh2d3c in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Sh2d3c | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Sh2d3c (SH2 domain containing 3C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, signal transduction, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, phospho... |
Does Knockout of Filip1l in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Filip1l | cell proliferation | Mouse kidney carcinoma cell | Gene: Filip1l (filamin A interacting protein 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, gene expression, hindgut development, intracellular protein localization, proteasomal protein catabolic process, protein localization to actin cytoskel... |
Does Knockout of Hsd17b12 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Hsd17b12 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen biosynthetic process, extracellular matrix organization, fatty acid biosynthetic process, fatty acid elongation, saturated fatty acid, lipid metabolic proce... |
Does Knockout of Smpdl3b in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Smpdl3b | protein/peptide distribution | Microglial Cell Line | Gene: Smpdl3b (sphingomyelin phosphodiesterase, acid-like 3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, inflammatory response, innate immune response, lipid catabolic process, lipid metabolic process, membrane lipid catabolic process, negative... |
Does Knockout of Ahsa2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Ahsa2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Ahsa2 (AHA1, activator of heat shock protein ATPase 2)
Type: protein-coding
Summary: Predicted to enable ATPase activator activity. Predicted to be involved in protein folding. Predicted to be active in cytosol. Is expressed in brain; cerebral cortex ventricular layer; and cortical plate. Ortholog... |
Does Knockout of Dpp9 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Dpp9 | protein/peptide distribution | Microglial Cell Line | Gene: Dpp9 (dipeptidylpeptidase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CARD8 inflammasome complex assembly, NLRP1 inflammasome complex assembly, negative regulation of programmed cell death, protein maturation, proteolysis, pyroptotic cell death, pyroptotic in... |
Does Knockout of Mogat2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Mogat2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Mogat2 (monoacylglycerol O-acyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: diacylglycerol biosynthetic process, glycerol metabolic process, intestinal absorption, lipid metabolic process, monoacylglycerol biosynthetic process, monoacylglycerol met... |
Does Knockout of S100a16 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | S100a16 | cell viability | Immortal mouse chromaffin cells | Gene: S100a16 (S100 calcium binding protein A16)
Type: protein-coding
Summary: Enables calcium ion binding activity and identical protein binding activity. Acts upstream of or within response to calcium ion. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricula... |
Does Knockout of Saraf in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Saraf | response to bacteria | renal medulla cell line | Gene: Saraf (store-operated calcium entry-associated regulatory factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transport, monoatomic ion transport, regulation of store-operated calcium entry; CC: endoplasmic reticulum, endoplasmic reticulum membrane, ... |
Does Knockout of Pgpep1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Pgpep1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Pgpep1 (pyroglutamyl-peptidase I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein catabolic process, proteolysis; MF: cysteine-type peptidase activity, hydrolase activity, peptidase activity, pyroglutamyl-peptidase activity; CC: cytoplasm, cytosol
P... |
Does Knockout of Slc30a9 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Slc30a9 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Slc30a9 (solute carrier family 30 (zinc transporter), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular zinc ion homeostasis, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transport, positive regulation ... |
Does Knockout of Dmrt1 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Dmrt1 | protein/peptide accumulation | Melanoma Cell Line | Gene: Dmrt1 (doublesex and mab-3 related transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Sertoli cell development, Sertoli cell differentiation, cell differentiation, cell morphogenesis, developmental process involved in reproduction, germ cell mig... |
Does Knockout of Prkce in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Prkce | protein/peptide distribution | myoblast cell line | Gene: Prkce (protein kinase C, epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TRAM-dependent toll-like receptor 4 signaling pathway, cell adhesion, cell division, cellular response to ethanol, cellular response to hypoxia, cellular response to platelet-derived g... |
Does Knockout of Pcdhac1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Pcdhac1 | cell proliferation | Colonic Cancer Cell Line | Gene: Pcdhac1 (protocadherin alpha subfamily C, 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, pl... |
Does Knockout of Ctsr in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Ctsr | cell proliferation | Mouse kidney carcinoma cell | Gene: Ctsr (cathepsin R)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase ac... |
Does Knockout of Amelx in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,565 | Knockout | Amelx | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Amelx (amelogenin, X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amelogenesis, biomineral tissue development, cell adhesion, enamel mineralization, odontogenesis of dentin-containing tooth, regulation of cell population proliferation, response to calcium... |
Does Knockout of Rad54b in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Rad54b | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Rad54b (RAD54 homolog B (S. cerevisiae))
Type: protein-coding
Summary: Predicted to enable DNA translocase activity. Acts upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation.... |
Does Knockout of Mcam in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Mcam | protein/peptide distribution | myoblast cell line | Gene: Mcam (melanoma cell adhesion molecule)
Type: protein-coding
Summary: Predicted to enable laminin receptor activity. Predicted to be involved in angiogenesis and positive regulation of cell migration. Predicted to act upstream of or within heterophilic cell-cell adhesion via plasma membrane cell ad... |
Does Knockout of Pcnx2 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Pcnx2 | protein/peptide accumulation | Mouse cell | Gene: Pcnx2 (pecanex homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q5DU28
Entrez ID: 270109 |
Does Knockout of Vmn2r67 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Vmn2r67 | protein/peptide accumulation | Embryonic Cell Line | Gene: Vmn2r67 (vomeronasal 2, receptor 67)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, sign... |
Does Knockout of Parl in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Parl | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Parl (presenilin associated, rhomboid-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: membrane protein proteolysis, mitochondrial fusion, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of release of cytochrome c from mitochon... |
Does Knockout of Ankdd1b in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Ankdd1b | protein/peptide accumulation | Mouse cell | Gene: Ankdd1b (ankyrin repeat and death domain containing 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, signal transduction
Pathways:
UniProt: Q14DN9
Entrez ID: 271144 |
Does Knockout of Gm21379 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Gm21379 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Gm21379 (predicted gene, 21379)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9D3U4
Entrez ID: 100861987 |
Does Knockout of Krtap2-4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Krtap2-4 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Krtap2-4 (keratin associated protein 2-4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q9D3H4
Entrez ID: 71453 |
Does Knockout of E2f1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | E2f1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: E2f1 (E2F transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA-templated transcription, anoikis, apoptotic process, cellular response to fatty acid, cellular response to hypoxia, cellular response to nerve grow... |
Does Knockout of Esp24 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Esp24 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Esp24 (exocrine gland secreted peptide 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, signal transduction; MF: pheromone activity; CC: extracellular space
Pathways:
UniProt: A8R0V6
Entrez ID: 100126776 |
Does Knockout of Phlpp1 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Phlpp1 | protein/peptide accumulation | Mouse cell | Gene: Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, entrainment of circadian clock, intracellular signal transduction, negative regulation of intracellular signal transduction, negative ... |
Does Knockout of Tapbp in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,271 | Knockout | Tapbp | cell proliferation | Mouse kidney carcinoma cell | Gene: Tapbp (TAP binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MHC class Ib protein complex assembly, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of exogenous peptide antigen via... |
Does Knockout of Ercc2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Ercc2 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, UV protection, apoptotic process, bone mineralization, central... |
Does Knockout of Nsun5 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 684 | Knockout | Nsun5 | cell proliferation | Acute Myeloid Leukemia Cell Line | Gene: Nsun5 (NOL1/NOP2/Sun domain family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, cerebral cortex development, cognition, corpus callosum development, methylation, oligodendrocyte development, positive regulation of translation, rRNA bas... |
Does Knockout of Rab5a in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation? | 0 | 1,522 | Knockout | Rab5a | protein/peptide accumulation | Embryonic Fibroblast Cell Line | Gene: Rab5a (RAB5A, member RAS oncogene family)
Type: protein-coding
Summary: Enables GTPase activity and guanyl nucleotide binding activity. Acts upstream of or within endocytosis. Located in several cellular components, including cytoplasmic vesicle; membrane raft; and ruffle. Is expressed in several ... |
Does Knockout of Slc7a6os in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Slc7a6os | protein/peptide accumulation | Microglial Cell Line | Gene: Slc7a6os (solute carrier family 7, member 6 opposite strand)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: developmental process, hematopoietic progenitor cell differentiation, protein transport; CC: cellular_component, cytoplasm, nucleus
Pathways:
... |
Does Knockout of Vps53 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Vps53 | response to bacteria | renal medulla cell line | Gene: Vps53 (VPS53 GARP complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytosolic transport, endocytic recycling, lysosomal transport, protein targeting to lysosome, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated cholesterol ... |
Does Knockout of Ppp2r5a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Ppp2r5a | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Ppp2r5a (protein phosphatase 2, regulatory subunit B', alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of protein localization to plasma membrane, signal transduction; MF: kinase binding, kinase inhibitor activity, protein binding, protein... |
Does Knockout of Dnajc21 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 84 | Knockout | Dnajc21 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Dnajc21 (DnaJ heat shock protein family (Hsp40) member C21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, nucleic acid binding, zinc ion binding; CC: cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt... |
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