prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Klhdc7b in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Klhdc7b | response to chemicals | pro-B-lymphocyte | Gene: Klhdc7b (kelch domain containing 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A286YD60, E9Q9M9
Entrez ID: 546648 |
Does Knockout of Mrpl52 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Mrpl52 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Mrpl52 (mitochondrial ribosomal protein L52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucle... |
Does Knockout of Eno1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Eno1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Eno1 (enolase 1, alpha non-neuron)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, cellular response to interleukin-7, gluconeogenesis, glyceraldehyde-3-phosphate biosynthetic process, glycolytic process, in utero embryonic development, negativ... |
Does Knockout of Gadl1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Gadl1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Gadl1 (glutamate decarboxylase-like 1)
Type: protein-coding
Summary: Predicted to enable carboxy-lyase activity. Predicted to be involved in carboxylic acid metabolic process. Predicted to be active in cytoplasm. Orthologous to human GADL1 (glutamate decarboxylase like 1). [provided by Alliance of... |
Does Knockout of Il23a in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,181 | Knockout | Il23a | tumorigenicity | Colonic Cancer Cell Line | Gene: Il23a (interleukin 23, alpha subunit p19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, defense response to Gram-negative bacterium, defen... |
Does Knockout of Cetn4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Cetn4 | protein/peptide distribution | myoblast cell line | Gene: Cetn4 (centrin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, microtubule cytoskeleton organization; MF: G-protein beta/gamma-subunit complex binding, calcium ion binding, heterotrimeric G-protein binding, metal ion binding; CC: centriole,... |
Does Knockout of Trim54 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Trim54 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Trim54 (tripartite motif-containing 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, innate immune response, negative regulation of microtubule depolymerization; MF: metal ion binding, microtubule binding, protein binding, ubiquitin protein ... |
Does Knockout of Dhx16 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,262 | Knockout | Dhx16 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Dhx16 (DEAH-box helicase 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, antiviral innate immune response, immune system process, innate immune response, mRNA processing, mRNA splicing, via spliceosome; MF: ATP binding, ATP-dependent activity, acti... |
Does Knockout of Cabp2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Cabp2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Cabp2 (calcium binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: sensory perception of sound, visual perception; MF: calcium channel regulator activity, calcium ion binding, metal ion binding; CC: Golgi apparatus, cytoplasm, membrane, perinuclear re... |
Does Knockout of Apoe in Melanoma Cell Line causally result in cell proliferation? | 1 | 1,269 | Knockout | Apoe | cell proliferation | Melanoma Cell Line | Gene: Apoe (apolipoprotein E)
Type: protein-coding
Summary: This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal cata... |
Does Knockout of Oas3 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Oas3 | cell proliferation | Melanoma Cell Line | Gene: Oas3 (2'-5' oligoadenylate synthetase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MDA-5 signaling pathway, RIG-I signaling pathway, antiviral innate immune response, cellular response to exogenous dsRNA, defense response to bacterium, defense response to viru... |
Does Knockout of Rs1 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Rs1 | response to virus | Neuroblastoma Cell Line | Gene: Rs1 (retinoschisis (X-linked, juvenile) 1 (human))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, eye development, protein homooligomerization, retina layer formation, visual perception; MF: lipid binding, phosphatidylinositol-3,4,5-trisphosphate bin... |
Does Knockout of Lyst in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Lyst | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Lyst (lysosomal trafficking regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell mediated immunity, blood coagulation, defense response to bacterium, defense response to other organism, defense response to protozoan, defense response to virus, endosome ... |
Does Knockout of Pfn3 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Pfn3 | cell proliferation | Melanoma Cell Line | Gene: Pfn3 (profilin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, positive regulation of actin filament bundle assembly, regulation of actin filament polymerization; MF: actin binding, lipid binding, protein binding; CC: cytoplasm, c... |
Does Knockout of Ptpru in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Ptpru | response to bacteria | renal medulla cell line | Gene: Ptpru (protein tyrosine phosphatase receptor type U)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ regeneration, cell adhesion, cell differentiation, homotypic cell-cell adhesion, negative regulation of canonical Wnt signaling pathway, negative regula... |
Does Knockout of Nod2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Nod2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Nod2 (nucleotide-binding oligomerization domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of immune response, adaptive immune response, antibacterial innate immune response, autophagy, canonical NF-kappaB signal transduction, cellular ... |
Does Knockout of Klhl3 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Klhl3 | response to virus | Microglial Cell Line | Gene: Klhl3 (kelch-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: distal tubule morphogenesis, gene expression, monoatomic ion homeostasis, potassium ion homeostasis, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitina... |
Does Knockout of Hyi in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,679 | Knockout | Hyi | protein/peptide distribution | myoblast cell line | Gene: Hyi (hydroxypyruvate isomerase (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydroxypyruvate isomerase activity, isomerase activity
Pathways: Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse)
UniProt: Q8R1F5
Entre... |
Does Knockout of Wfikkn2 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Wfikkn2 | phagocytosis | macrophage | Gene: Wfikkn2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: muscle cell development, negative regulation of transforming growth factor beta receptor signaling pathway, roof of mouth developm... |
Does Knockout of Garem2 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Garem2 | response to virus | Microglial Cell Line | Gene: Garem2 (GRB2 associated regulator of MAPK1 subtype 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cognition, neuron projection extension, response to stress, social behavior; MF: molecular_function, protein binding
Pathways:
... |
Does Knockout of Mrpl54 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Mrpl54 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Mrpl54 (mitochondrial ribosomal protein L54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondr... |
Does Knockout of Cetn3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Cetn3 | protein/peptide distribution | myoblast cell line | Gene: Cetn3 (centrin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, mRNA transport, microtubule cytoskeleton organization, protein transport; MF: G-protein beta/gamma-subunit complex binding, calcium ion binding, metal ion binding, microtubule binding; ... |
Does Knockout of Tra2b in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Tra2b | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Tra2b (transformer 2 beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cellular response to glucose stimulus, cerebral cortex regionalization, embryonic brain development, mRNA processing, mRNA splicing, via spliceosome, positive regulation of mRNA... |
Does Knockout of Xkr8 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Xkr8 | phagocytosis | macrophage | Gene: Xkr8 (X-linked Kx blood group related 8)
Type: protein-coding
Summary: Enables phospholipid scramblase activity. Involved in apoptotic cell clearance; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of myoblast differentiation. Acts upstream of or within establishmen... |
Does Knockout of Zfp938 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 165 | Knockout | Zfp938 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Zfp938 (zinc finger protein 938)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, meta... |
Does Knockout of Ampd2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Ampd2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Ampd2 (adenosine monophosphate deaminase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMP metabolic process, ATP metabolic process, GMP salvage, GTP metabolic process, IMP biosynthetic process, IMP salvage, cholesterol homeostasis, cyclic purine nucleotide met... |
Does Knockout of Ccnc in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Ccnc | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Ccnc (cyclin C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G0 to G1 transition, negative regulation of Notch signaling pathway, negative regulation of triglyceride metabolic process, positive regulation of transcription by RNA polymerase II, protein ubiquitinat... |
Does Knockout of Bmpr2 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Bmpr2 | cell proliferation | Embryonic Stem Cell Line | Gene: Bmpr2 (bone morphogenetic protein receptor type 2)
Type: protein-coding
Summary: This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type ... |
Does Knockout of Pomt2 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,685 | Knockout | Pomt2 | protein/peptide distribution | myoblast cell line | Gene: Pomt2 (protein-O-mannosyltransferase 2)
Type: protein-coding
Summary: This gene encodes an integral membrane protein that belongs to the dolichyl-phosphate-mannose-protein mannosyltransferase family. The encoded enzyme is found in the membrane of the endoplasmic reticulum. This protein is a compon... |
Does Knockout of Wbp11 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Wbp11 | protein/peptide accumulation | Melanoma Cell Line | Gene: Wbp11 (WW domain binding protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, rRNA processing; MF: WW domain binding, protein binding, protein phosphatase regulator activity; CC: cytoplasm, cytosol, nuclear speck... |
Does Knockout of Col17a1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,663 | Knockout | Col17a1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Col17a1 (collagen, type XVII, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hemidesmosome assembly; MF: extracellular matrix structural constituent conferring tensile strength, protein binding; CC: anchoring junction, basement membrane, collagen trimer, e... |
Does Knockout of Zfp518b in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Zfp518b | cell proliferation | Melanoma Cell Line | Gene: Zfp518b (zinc finger protein 518B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zi... |
Does Knockout of Pth2r in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Pth2r | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Pth2r (parathyroid hormone 2 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, positive regulati... |
Does Knockout of Vmn1r229 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Vmn1r229 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Vmn1r229 (vomeronasal 1 receptor 229)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromon... |
Does Knockout of Plp2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Plp2 | cell proliferation | Melanoma Cell Line | Gene: Plp2 (proteolipid protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: chemokine binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9R1Q7
Entrez ID: 18824 |
Does Knockout of Adam34 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Adam34 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Adam34 (a disintegrin and metallopeptidase domain 34)
Type: protein-coding
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Is e... |
Does Knockout of Aqp8 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Aqp8 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Aqp8 (aquaporin 8)
Type: protein-coding
Summary: Enables ammonium channel activity; urea channel activity; and water channel activity. Involved in several processes, including ammonium import across plasma membrane; hydrogen peroxide transmembrane transport; and urea transport. Located in several ... |
Does Knockout of Hipk2 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Hipk2 | protein/peptide accumulation | Embryonic Cell Line | Gene: Hipk2 (homeodomain interacting protein kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, SMAD protein signal transduction, adult locomotory behavior, adult walking behavior,... |
Does Knockout of Arfip1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,565 | Knockout | Arfip1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Arfip1 (ARF interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein localization, intracellular protein transport, negative regulation of retrograde transport, endosome to Golgi, regulation of Arp2/3 complex-mediated actin nuclea... |
Does Knockout of Ripor3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 165 | Knockout | Ripor3 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ripor3 (RIPOR family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A1L3T7
Entrez ID: 69553 |
Does Knockout of Acat2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Acat2 | cell proliferation | Colonic Cancer Cell Line | Gene: Acat2 (acetyl-Coenzyme A acetyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, fatty acid metabolic process, isopentenyl diphosphate biosynthetic proce... |
Does Knockout of Bbs12 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Bbs12 | protein/peptide distribution | myoblast cell line | Gene: Bbs12 (Bardet-Biedl syndrome 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated protein complex assembly, eating behavior, intraciliary transport, negative regulation of fat cell differentiation, negative regulation of stem cell differentiation, ... |
Does Knockout of Atp6v1b2 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,263 | Knockout | Atp6v1b2 | cell proliferation | Colonic Cancer Cell Line | Gene: Atp6v1b2 (ATPase, H+ transporting, lysosomal V1 subunit B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification, vacuolar acidification; MF: ATP binding... |
Does Knockout of Unc93b1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Unc93b1 | cell proliferation | Melanoma Cell Line | Gene: Unc93b1 (unc-93 homolog B1, TLR signaling regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell antigen processing and presentation, adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide a... |
Does Knockout of Pip4k2a in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Pip4k2a | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Pip4k2a (phosphatidylinositol-5-phosphate 4-kinase, type II, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process, autophagosome-lysosome fusion, lipid metabolic process, megakaryocyte developmen... |
Does Knockout of Mthfd2 in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Mthfd2 | cell proliferation | Regulatory T cell | Gene: Mthfd2 (methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carboxylic acid metabolic process, formate biosynthetic process, one-carbon metabolic process, tetrahydrofolate... |
Does Knockout of Arhgef12 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Arhgef12 | protein/peptide distribution | myoblast cell line | Gene: Arhgef12 (Rho guanine nucleotide exchange factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho protein signal transduction, Rho-activating G protein-coupled receptor signaling pathway, intracellular signal tran... |
Does Knockout of Acy1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Acy1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Acy1 (aminoacylase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid metabolic process, protein catabolic process; MF: aminoacylase activity, hydrolase activity, identical protein binding, metal ion binding; CC: cytoplasm, extracellular exosome
... |
Does Knockout of Rpl19 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Rpl19 | cell proliferation | Embryonic Stem Cell Line | Gene: Rpl19 (ribosomal protein L19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation; MF: 5.8S rRNA binding, RNA binding, large ribosomal subunit rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ... |
Does Knockout of Mss51 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Mss51 | cell proliferation | Mouse kidney carcinoma cell | Gene: Mss51 (MSS51 mitochondrial translational activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q9D5Z5
Entrez ID: 74843 |
Does Knockout of Helb in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Helb | cell proliferation | Colonic Cancer Cell Line | Gene: Helb (helicase (DNA) B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA replication, DNA replication, synthesis of primer, DNA-templated DNA replication, negative regulation of double-strand break repair via homologous recombination, regulat... |
Does Knockout of Map4k4 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Map4k4 | protein/peptide accumulation | Embryonic Cell Line | Gene: Map4k4 (mitogen-activated protein kinase kinase kinase kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, hippo signaling, intracellular signal transduction, negative regulation of apoptotic process, negative regulation of insulin secretion invo... |
Does Knockout of Prg3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Prg3 | protein/peptide distribution | myoblast cell line | Gene: Prg3 (proteoglycan 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: basophil activation, histamine biosynthetic process, immune response, leukotriene biosynthetic process, negative regulation of translation, neutrophil activation, positive regulation of interleuki... |
Does Knockout of Aurkc in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Aurkc | cell proliferation | Colonic Cancer Cell Line | Gene: Aurkc (aurora kinase C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, meiotic cell cycle, mitotic spindle organization, protein phosphorylation, regulation of cytokinesis; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity... |
Does Knockout of Tmem106c in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Tmem106c | response to bacteria | renal medulla cell line | Gene: Tmem106c (transmembrane protein 106C)
Type: protein-coding
Summary: Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including brain and retina. Orthologous to human TMEM106C (transmembrane protein 106C). [provided by Alliance of Genome Resources, Jul ... |
Does Knockout of Nap1l4 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,176 | Knockout | Nap1l4 | cell proliferation | Colonic Cancer Cell Line | Gene: Nap1l4 (nucleosome assembly protein 1-like 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly; MF: chromatin binding, histone binding, nucleosome binding; CC: chromatin, cytoplasm, dendrite, neuronal cell body, nucleus
Pathways:
... |
Does Knockout of Tubd1 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Tubd1 | protein/peptide accumulation | Microglial Cell Line | Gene: Tubd1 (tubulin, delta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle, positive regulation of smoothened signaling pathway; MF: GTP binding, nucleot... |
Does Knockout of Cbr1 in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Cbr1 | cell proliferation | Regulatory T cell | Gene: Cbr1 (carbonyl reductase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucocorticoid metabolic process, lipid metabolic process, phylloquinone catabolic process, positive regulation of reactive oxygen species metabolic process, prostaglandin catabolic process,... |
Does Knockout of Ampd3 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Ampd3 | protein/peptide accumulation | Embryonic Cell Line | Gene: Ampd3 (adenosine monophosphate deaminase 3)
Type: protein-coding
Summary: This gene encodes a member of the adenosine and AMP deaminases family. The encoded protein is an AMP deaminase involved in nucleotide and energy metabolism in erythrocytes. Alternative splicing results in multiple transcript... |
Does Knockout of Crtc2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Crtc2 | cell proliferation | Melanoma Cell Line | Gene: Crtc2 (CREB regulated transcription coactivator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to cAMP, gluconeogenesis, glucose homeostasis, positive regulation of CREB transcription factor activity, positive regulation of transcription by RNA... |
Does Knockout of Foxk1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Foxk1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Foxk1 (forkhead box K1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, cell differentiation, intracellular glucose homeostasis, muscle organ development, negative regulation of DNA-templated transcription, negative regulation of autophagy, neg... |
Does Knockout of Drd3 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Drd3 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Drd3 (dopamine receptor D3)
Type: protein-coding
Summary: Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in behavioral response to cocaine and regulation of neurotransmitter uptake. Acts upstream of or within several processes, including adenylate cyclase-activati... |
Does Knockout of Cttnbp2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,260 | Knockout | Cttnbp2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Cttnbp2 (cortactin binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of modification of postsynaptic actin cytoskeleton, regulation of synapse organization; MF: SH3 domain binding, protein binding; CC: FAR/SIN/STRIPAK complex, cell cortex... |
Does Knockout of Slc26a4 in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Slc26a4 | cell proliferation | Regulatory T cell | Gene: Slc26a4 (solute carrier family 26, member 4)
Type: protein-coding
Summary: Enables chloride:bicarbonate antiporter activity. Involved in regulation of pH and regulation of protein localization. Located in apical plasma membrane and brush border membrane. Is expressed in central nervous system; inn... |
Does Knockout of Tec in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Tec | protein/peptide distribution | myoblast cell line | Gene: Tec (tec protein tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell receptor signaling pathway, T cell receptor signaling pathway, adaptive immune response, immune system process, integrin-mediated signaling pathway, intracellular signal transdu... |
Does Knockout of Golim4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | Golim4 | protein/peptide distribution | myoblast cell line | Gene: Golim4 (golgi integral membrane protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, endosome, endosome membrane, membrane
Pathways:
UniProt: Q8BXA1
Entrez ID: 73124 |
Does Knockout of Lsp1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,260 | Knockout | Lsp1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Lsp1 (lymphocyte specific 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to interleukin-7, chemotaxis, cytoskeleton organization, defense response, signal transduction; MF: actin binding; CC: membrane, plasma membrane
... |
Does Knockout of Ccdc182 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Ccdc182 | phagocytosis | macrophage | Gene: Ccdc182 (coiled-coil domain containing 182)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, female gonad development
Pathways:
UniProt: Q9D9C6
Entrez ID: 74297 |
Does Knockout of Nol8 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Nol8 | response to bacteria | renal medulla cell line | Gene: Nol8 (nucleolar protein 8)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in chromosome. Predicted to be active in nucleolus. Is expressed in central nervous system and sens... |
Does Knockout of Pnpla1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Pnpla1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Pnpla1 (patatin-like phospholipase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, establishment of skin barrier, keratinocyte differentiation, lipid catabolic process, lipid homeostasis, lipid metabolic process, o... |
Does Knockout of Gm9905 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Gm9905 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Gm9905 (predicted gene 9905)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Fktn in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Fktn | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Fktn (fukutin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: basement membrane organization, brain development, cerebellar cortex development, cerebral cortex development, glycoprotein metabolic process, negative regulation of JNK cascade, negative regulation of c... |
Does Knockout of Stat5b in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,176 | Knockout | Stat5b | cell proliferation | Colonic Cancer Cell Line | Gene: Stat5b (signal transducer and activator of transcription 5B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, Peyer's patch development, T cell differentiation in thymus, T cell homeostasis, activated T cell proliferation, acute-phase response... |
Does Knockout of Fer1l4 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Fer1l4 | protein/peptide accumulation | Microglial Cell Line | Gene: Fer1l4 (fer-1 like family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function; CC: cellular_component, membrane
Pathways:
UniProt: F6YZT0, Z4YL23, F6UNQ3
Entrez ID: 74562 |
Does Knockout of Ankrd60 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Ankrd60 | cell proliferation | Regulatory T cell | Gene: Ankrd60 (ankyrin repeat domain 60)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2AMD2, A0A6I8MWY2, A6PWV4
Entrez ID: 70065 |
Does Knockout of Tmem176b in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Tmem176b | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Tmem176b (transmembrane protein 176B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of dendritic cell differentiation; CC: membrane, nuclear membrane, nucleus
Pathways:
UniProt: Q9R1Q6
Entrez ID:... |
Does Knockout of 2300009A05Rik in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | 2300009A05Rik | cell cycle progression | breast epithelium | Gene: 2300009A05Rik (RIKEN cDNA 2300009A05 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: Q0VG49
Entrez ID: 69478 |
Does Knockout of Sult1c1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Sult1c1 | cell proliferation | Melanoma Cell Line | Gene: Sult1c1 (sulfotransferase family, cytosolic, 1C, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate metabolic process, sulfation, sulfur compound metabolic process, xenobiotic metabolic process; MF: 3'-phosphoadenosine 5'... |
Does Knockout of Elovl6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Elovl6 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Elovl6 (ELOVL fatty acid elongase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid elongation, fatty acid elongation, monounsaturated fatty acid, fatty acid elongation, polyunsaturated fatty acid, fatty acid elongation, ... |
Does Knockout of Cyp1b1 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Cyp1b1 | cell proliferation | Regulatory T cell | Gene: Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA modification, angiogenesis, arachidonate metabolic process, benzene-containing compound metabolic process, blood vessel endothelial cell migration, blo... |
Does Knockout of Tmem256 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Tmem256 | protein/peptide distribution | myoblast cell line | Gene: Tmem256 (transmembrane protein 256)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, mitochondrial inner membrane
Pathways:
UniProt: Q5F285
Entrez ID: 69186 |
Does Knockout of Zfp711 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Zfp711 | cell proliferation | Mouse kidney carcinoma cell | Gene: Zfp711 (zinc finger protein 711)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcript... |
Does Knockout of En2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | En2 | cell proliferation | Melanoma Cell Line | Gene: En2 (engrailed 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central nervous system neuron differentiation, dopaminergic neuron differentiation, embryonic brain development, hindbrain development, midbrain development, negative regulation of neuron apoptotic pr... |
Does Knockout of Slc12a8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Slc12a8 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Slc12a8 (solute carrier family 12 (potassium/chloride transporters), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell volume homeostasis, chloride ion homeostasis, chloride transmembrane transport, inorganic cation transmembrane transport, metal ion tr... |
Does Knockout of Btbd35f20 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Btbd35f20 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Btbd35f20 (BTB domain containing 35, family member 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, germ cell development
Pathways:
UniProt: A2CG71
Entrez ID: 668963 |
Does Knockout of Abcc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 84 | Knockout | Abcc1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Abcc1 (ATP-binding cassette, sub-family C member 1)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC... |
Does Knockout of Dpp9 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Dpp9 | cell proliferation | Regulatory T cell | Gene: Dpp9 (dipeptidylpeptidase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CARD8 inflammasome complex assembly, NLRP1 inflammasome complex assembly, negative regulation of programmed cell death, protein maturation, proteolysis, pyroptotic cell death, pyroptotic in... |
Does Knockout of Krt8 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Krt8 | protein/peptide accumulation | Microglial Cell Line | Gene: Krt8 (keratin 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation involved in embryonic placenta development, extrinsic apoptotic signaling pathway, hepatocyte apoptotic process, response to hydrostatic pressure, response to other organism, sarco... |
Does Knockout of Krtap1-5 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Krtap1-5 | cell proliferation | Embryonic Stem Cell Line | Gene: Krtap1-5 (keratin associated protein 1-5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q9D6Z9, A2A590
Entrez ID... |
Does Knockout of Cpsf4l in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Cpsf4l | cell proliferation | Mouse kidney carcinoma cell | Gene: Cpsf4l (cleavage and polyadenylation specific factor 4-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA 3'-end processing, mRNA processing; MF: RNA binding, metal ion binding, zinc ion binding; CC: mRNA cleavage and polyadenylation specificity factor compl... |
Does Knockout of Ift140 in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Ift140 | response to bacteria | macrophage | Gene: Ift140 (intraflagellar transport 140)
Type: protein-coding
Summary: Acts upstream of or within several processes, including cilium organization; embryonic organ development; and regionalization. Located in cytoskeleton and photoreceptor cell cilium. Part of intraciliary transport particle A. Is ex... |
Does Knockout of Homer2 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Homer2 | cell proliferation | Embryonic Stem Cell Line | Gene: Homer2 (homer scaffolding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled glutamate receptor signaling pathway, behavioral response to cocaine, calcium-mediated signaling, negative regulation of calcineurin-NFAT signaling cascade, negati... |
Does Knockout of Eng in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 163 | Knockout | Eng | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Eng (endoglin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, artery morphogenesis, atrial cardiac muscle tissue morphogenesis, atrioventricular canal morphogenesis, branching involved in blood vessel morphogenesis, cardiac atrium morphogenesis, cardi... |
Does Knockout of Glipr2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Glipr2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Glipr2 (GLI pathogenesis-related 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of ERK1 and ERK2 cascade, positive regulation of epithelial cell migration, positive regulation of epithelial to mesenchymal transition, sexual reproduction; MF: ... |
Does Knockout of Top3a in Colonic Cancer Cell Line causally result in tumorigenicity? | 1 | 2,178 | Knockout | Top3a | tumorigenicity | Colonic Cancer Cell Line | Gene: Top3a (topoisomerase (DNA) III alpha)
Type: protein-coding
Summary: Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity and single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process and chromosome separation. Predicted to be loca... |
Does Knockout of Prpsap1 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Prpsap1 | protein/peptide accumulation | Melanoma Cell Line | Gene: Prpsap1 (phosphoribosyl pyrophosphate synthetase-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 5-phosphoribose 1-diphosphate biosynthetic process, nucleotide biosynthetic process, purine nucleotide biosynthetic process; MF: enzyme regulator a... |
Does Knockout of Ddn in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Ddn | phagocytosis | macrophage | Gene: Ddn (dendrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding;... |
Does Knockout of Ttc8 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Ttc8 | cell proliferation | Melanoma Cell Line | Gene: Ttc8 (tetratricopeptide repeat domain 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, axon guidance, camera-type eye photoreceptor cell differentiation, cell projection organization, cilium assembly, establishment of anatomical... |
Does Knockout of Tas2r107 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,565 | Knockout | Tas2r107 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Tas2r107 (taste receptor, type 2, member 107)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sens... |
Does Knockout of Sp8 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Sp8 | protein/peptide accumulation | Microglial Cell Line | Gene: Sp8 (trans-acting transcription factor 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dorsal/ventral pattern formation, embryonic limb morphogenesis, proximal/distal pattern formation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-bindin... |
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