prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Klhdc7b in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Klhdc7b
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Klhdc7b (kelch domain containing 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A286YD60, E9Q9M9
Entrez ID: 546648
|
Does Knockout of Mrpl52 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Mrpl52
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mrpl52 (mitochondrial ribosomal protein L52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D0Y8
Entrez ID: 68836
|
Does Knockout of Eno1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Eno1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Eno1 (enolase 1, alpha non-neuron)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, cellular response to interleukin-7, gluconeogenesis, glyceraldehyde-3-phosphate biosynthetic process, glycolytic process, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of cell growth, negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of ATP biosynthetic process, positive regulation of muscle contraction, positive regulation of plasminogen activation; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, GTPase binding, RNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, enzyme binding, heat shock protein binding, identical protein binding, lyase activity, magnesium ion binding, metal ion binding, phosphopyruvate hydratase activity, protein binding, protein homodimerization activity, protein-containing complex binding, transcription corepressor activity, transcription corepressor binding; CC: cell cortex, cell surface, cytoplasm, cytosol, growth cone, membrane, membrane raft, myelin sheath, nuclear outer membrane, phosphopyruvate hydratase complex, plasma membrane, synaptic membrane
Pathways: Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), RNA degradation - Mus musculus (mouse), gluconeogenesis I, glycolysis I, glycolysis III, glycolysis V (Pyrococcus)
UniProt: P17182
Entrez ID: 13806
|
Does Knockout of Gadl1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Gadl1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gadl1 (glutamate decarboxylase-like 1)
Type: protein-coding
Summary: Predicted to enable carboxy-lyase activity. Predicted to be involved in carboxylic acid metabolic process. Predicted to be active in cytoplasm. Orthologous to human GADL1 (glutamate decarboxylase like 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, carboxylic acid metabolic process; MF: aspartate 1-decarboxylase activity, carbon-carbon lyase activity, carboxy-lyase activity, lyase activity, molecular_function, pyridoxal phosphate binding, sulfinoalanine decarboxylase activity
Pathways: Aspartate and asparagine metabolism, Degradation of cysteine and homocysteine, Metabolism, Metabolism of amino acids and derivatives, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Sulfur amino acid metabolism, Taurine and hypotaurine metabolism - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse)
UniProt: Q80WP8
Entrez ID: 73748
|
Does Knockout of Il23a in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Il23a
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Il23a (interleukin 23, alpha subunit p19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, defense response to Gram-negative bacterium, defense response to virus, immune response, immune system process, inflammatory response, innate immune response, negative regulation of interleukin-10 production, positive regulation of NK T cell activation, positive regulation of NK T cell proliferation, positive regulation of T cell mediated cytotoxicity, positive regulation of T cell proliferation, positive regulation of T-helper 1 type immune response, positive regulation of T-helper 17 cell lineage commitment, positive regulation of T-helper 17 type immune response, positive regulation of activated T cell proliferation, positive regulation of alpha-beta T cell activation, positive regulation of defense response to virus by host, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-17 production, positive regulation of leukocyte differentiation, positive regulation of macromolecule biosynthetic process, positive regulation of memory T cell differentiation, positive regulation of natural killer cell proliferation, positive regulation of neutrophil chemotaxis, positive regulation of osteoclast differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, regulation of gene expression, regulation of primary metabolic process, tissue remodeling; MF: cytokine activity, interleukin-23 receptor binding, protein binding; CC: extracellular region, extracellular space, interleukin-23 complex
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-12 family signaling, Interleukin-23 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Signaling by Interleukins, Th17 cell differentiation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q9EQ14
Entrez ID: 83430
|
Does Knockout of Cetn4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Cetn4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cetn4 (centrin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, microtubule cytoskeleton organization; MF: G-protein beta/gamma-subunit complex binding, calcium ion binding, heterotrimeric G-protein binding, metal ion binding; CC: centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule organizing center, nucleus
Pathways:
UniProt: Q8K4K1
Entrez ID: 207175
|
Does Knockout of Trim54 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Trim54
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Trim54 (tripartite motif-containing 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, innate immune response, negative regulation of microtubule depolymerization; MF: metal ion binding, microtubule binding, protein binding, ubiquitin protein ligase activity, zinc ion binding; CC: Z disc, cytoplasm, cytoskeleton, microtubule, microtubule associated complex
Pathways:
UniProt: Q9ERP3
Entrez ID: 58522
|
Does Knockout of Dhx16 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Dhx16
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Dhx16 (DEAH-box helicase 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, antiviral innate immune response, immune system process, innate immune response, mRNA processing, mRNA splicing, via spliceosome; MF: ATP binding, ATP-dependent activity, acting on RNA, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, molecular adaptor activity, nucleic acid binding, nucleotide binding, pattern recognition receptor activity, ubiquitin binding; CC: U2-type precatalytic spliceosome, cytoplasm, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9CRI3, Q921Y1, G3X8X0, Q05BH3, G3UXT5
Entrez ID: 69192
|
Does Knockout of Cabp2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Cabp2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cabp2 (calcium binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: sensory perception of sound, visual perception; MF: calcium channel regulator activity, calcium ion binding, metal ion binding; CC: Golgi apparatus, cytoplasm, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q9JLK4
Entrez ID: 29866
|
Does Knockout of Apoe in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,269
|
Knockout
|
Apoe
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Apoe (apolipoprotein E)
Type: protein-coding
Summary: This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: AMPA glutamate receptor clustering, G protein-coupled receptor signaling pathway, NMDA glutamate receptor clustering, acylglycerol homeostasis, amyloid precursor protein metabolic process, artery development, artery morphogenesis, cellular oxidant detoxification, cellular response to amyloid-beta, cellular response to lipoprotein particle stimulus, cholesterol catabolic process, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, chylomicron remnant clearance, circulatory system development, fatty acid homeostasis, gene expression, high-density lipoprotein particle assembly, high-density lipoprotein particle clearance, high-density lipoprotein particle remodeling, host-mediated activation of viral process, intermediate-density lipoprotein particle clearance, intracellular calcium ion homeostasis, lipid homeostasis, lipid metabolic process, lipid transport, lipid transport involved in lipid storage, lipoprotein biosynthetic process, lipoprotein catabolic process, lipoprotein metabolic process, locomotory exploration behavior, long-chain fatty acid transport, long-term memory, low-density lipoprotein particle remodeling, maintenance of location in cell, melanosome organization, negative regulation of MAPK cascade, negative regulation of amyloid fibril formation, negative regulation of amyloid-beta formation, negative regulation of blood coagulation, negative regulation of blood vessel endothelial cell migration, negative regulation of canonical Wnt signaling pathway, negative regulation of cholesterol biosynthetic process, negative regulation of cholesterol efflux, negative regulation of dendritic spine development, negative regulation of dendritic spine maintenance, negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, negative regulation of gene expression, negative regulation of inflammatory response, negative regulation of lipid biosynthetic process, negative regulation of lipid metabolic process, negative regulation of lipid transport across blood-brain barrier, negative regulation of long-term synaptic potentiation, negative regulation of neuron projection development, negative regulation of phospholipid efflux, negative regulation of platelet activation, negative regulation of platelet-derived growth factor receptor signaling pathway, negative regulation of postsynaptic membrane organization, negative regulation of protein metabolic process, negative regulation of protein secretion, negative regulation of smooth muscle cell proliferation, negative regulation of triglyceride metabolic process, neuron projection development, nitric oxide-cGMP-mediated signaling, phospholipid efflux, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of amyloid-beta clearance, positive regulation of amyloid-beta formation, positive regulation of axon extension, positive regulation of cholesterol efflux, positive regulation of cholesterol metabolic process, positive regulation of dendritic spine development, positive regulation of dendritic spine maintenance, positive regulation of endocytosis, positive regulation of lipid biosynthetic process, positive regulation of lipid transport across blood-brain barrier, positive regulation of lipoprotein transport, positive regulation of low-density lipoprotein particle receptor catabolic process, positive regulation of membrane protein ectodomain proteolysis, positive regulation of neurofibrillary tangle assembly, positive regulation of neuron projection development, positive regulation of nitric oxide biosynthetic process, positive regulation of phospholipid efflux, positive regulation of presynaptic membrane organization, protein import, receptor-mediated endocytosis, regulation of Cdc42 protein signal transduction, regulation of amyloid fibril formation, regulation of amyloid precursor protein catabolic process, regulation of amyloid-beta clearance, regulation of apoptotic process, regulation of behavioral fear response, regulation of cellular response to very-low-density lipoprotein particle stimulus, regulation of cholesterol metabolic process, regulation of gene expression, regulation of innate immune response, regulation of plasma lipoprotein particle levels, regulation of proteasomal protein catabolic process, regulation of protein metabolic process, regulation of protein-containing complex assembly, regulation of synapse organization, regulation of triglyceride metabolic process, response to caloric restriction, response to dietary excess, response to oxidative stress, reverse cholesterol transport, triglyceride homeostasis, triglyceride metabolic process, triglyceride-rich lipoprotein particle clearance, vasodilation, very-low-density lipoprotein particle clearance, very-low-density lipoprotein particle remodeling, virion assembly; MF: amyloid-beta binding, antioxidant activity, cholesterol transfer activity, enzyme binding, heparan sulfate proteoglycan binding, heparin binding, hydroxyapatite binding, identical protein binding, lipid binding, lipid transporter activity, lipoprotein particle binding, low-density lipoprotein particle receptor binding, metal chelating activity, phosphatidylcholine-sterol O-acyltransferase activator activity, phospholipid binding, protein binding, protein dimerization activity, protein homodimerization activity, protein-containing complex binding, receptor ligand activity, signaling receptor binding, tau protein binding, very-low-density lipoprotein particle receptor binding; CC: Golgi apparatus, cell surface, chylomicron, chylomicron remnant, cytosol, dendrite, discoidal high-density lipoprotein particle, early endosome, endoplasmic reticulum, endosome, extracellular exosome, extracellular matrix, extracellular region, extracellular space, extracellular vesicle, extrinsic component of external side of plasma membrane, glutamatergic synapse, high-density lipoprotein particle, intermediate-density lipoprotein particle, late endosome, lipoprotein particle, low-density lipoprotein particle, melanosome, microtubule, multivesicular body, multivesicular body, internal vesicle, neuronal cell body, nuclear envelope, synaptic cleft, very-low-density lipoprotein particle
Pathways: Alzheimer disease - Mus musculus (mouse), Binding and Uptake of Ligands by Scavenger Receptors, Cholesterol metabolism - Mus musculus (mouse), Chylomicron assembly, Chylomicron clearance, Chylomicron remodeling, HDL remodeling, Metabolism, Metabolism of fat-soluble vitamins, Metabolism of proteins, Metabolism of vitamins and cofactors, Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Plasma lipoprotein remodeling, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Retinoid metabolism and transport, Scavenging by Class A Receptors, Sensory Perception, Transport of small molecules, Vesicle-mediated transport, Visual phototransduction
UniProt: P08226
Entrez ID: 11816
|
Does Knockout of Oas3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Oas3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Oas3 (2'-5' oligoadenylate synthetase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MDA-5 signaling pathway, RIG-I signaling pathway, antiviral innate immune response, cellular response to exogenous dsRNA, defense response to bacterium, defense response to virus, immune system process, innate immune response, interleukin-27-mediated signaling pathway, negative regulation of IP-10 production, negative regulation of chemokine (C-C motif) ligand 5 production, negative regulation of chemokine (C-X-C motif) ligand 2 production, negative regulation of chemokine (C-X-C motif) ligand 9 production, negative regulation of type I interferon-mediated signaling pathway, negative regulation of viral genome replication, positive regulation of interferon-beta production, positive regulation of monocyte chemotactic protein-1 production, positive regulation of tumor necrosis factor production, response to virus, type I interferon-mediated signaling pathway; MF: 2'-5'-oligoadenylate synthetase activity, ATP binding, RNA binding, double-stranded RNA binding, metal ion binding, nucleotide binding, nucleotidyltransferase activity, transferase activity; CC: cytoplasm, cytosol, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q8VI93
Entrez ID: 246727
|
Does Knockout of Rs1 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Rs1
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Rs1 (retinoschisis (X-linked, juvenile) 1 (human))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, eye development, protein homooligomerization, retina layer formation, visual perception; MF: lipid binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding, phosphatidylserine binding, protein-containing complex binding; CC: cell surface, external side of plasma membrane, extracellular region, extracellular space, membrane, neuron to neuron synapse, photoreceptor inner segment, plasma membrane, protein-containing complex
Pathways:
UniProt: Q9Z1L4
Entrez ID: 20147
|
Does Knockout of Lyst in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Lyst
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Lyst (lysosomal trafficking regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell mediated immunity, blood coagulation, defense response to bacterium, defense response to other organism, defense response to protozoan, defense response to virus, endosome to lysosome transport via multivesicular body sorting pathway, granulocyte chemotaxis, immune response, lymphocyte mediated immunity, lysosome organization, mast cell secretory granule organization, melanosome organization, microtubule-based process, natural killer cell mediated cytotoxicity, neutrophil mediated immunity, phagocytosis, phospholipid homeostasis, phospholipid metabolic process, pigment granule organization, pigmentation, positive regulation of natural killer cell activation, protein transport, response to xenobiotic stimulus, secretion of lysosomal enzymes; CC: cytoplasm, cytosol, microtubule cytoskeleton
Pathways:
UniProt: P97412
Entrez ID: 17101
|
Does Knockout of Pfn3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Pfn3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pfn3 (profilin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, positive regulation of actin filament bundle assembly, regulation of actin filament polymerization; MF: actin binding, lipid binding, protein binding; CC: cytoplasm, cytoskeleton, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse)
UniProt: Q9DAD6
Entrez ID: 75477
|
Does Knockout of Ptpru in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Ptpru
|
response to bacteria
|
renal medulla cell line
|
Gene: Ptpru (protein tyrosine phosphatase receptor type U)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ regeneration, cell adhesion, cell differentiation, homotypic cell-cell adhesion, negative regulation of canonical Wnt signaling pathway, negative regulation of cell migration, negative regulation of cell population proliferation, neuron projection development, positive regulation of cell-cell adhesion mediated by cadherin, protein localization to cell surface, response to glucocorticoid, signal transduction; MF: beta-catenin binding, hydrolase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity; CC: anchoring junction, cell-cell junction, membrane, plasma membrane
Pathways: Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT
UniProt: B1AUH1
Entrez ID: 19273
|
Does Knockout of Nod2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Nod2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nod2 (nucleotide-binding oligomerization domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of immune response, adaptive immune response, antibacterial innate immune response, autophagy, canonical NF-kappaB signal transduction, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, cellular response to peptidoglycan, defense response, defense response to Gram-positive bacterium, defense response to bacterium, detection of bacterium, detection of biotic stimulus, detection of muramyl dipeptide, establishment of localization in cell, host-mediated modulation of intestinal microbiota composition, immune system process, inflammatory response, innate immune response, innate immune response in mucosa, intestinal stem cell homeostasis, intracellular signal transduction, maintenance of gastrointestinal epithelium, negative regulation of T cell mediated immunity, negative regulation of canonical NF-kappaB signal transduction, negative regulation of inflammatory response to antigenic stimulus, negative regulation of interleukin-12 production, negative regulation of interleukin-18 production, negative regulation of interleukin-2 production, negative regulation of macrophage apoptotic process, negative regulation of macrophage cytokine production, negative regulation of toll-like receptor 2 signaling pathway, negative regulation of tumor necrosis factor production, negative regulation of type II interferon production, nucleotide-binding oligomerization domain containing 2 signaling pathway, p38MAPK cascade, pattern recognition receptor signaling pathway, positive regulation of B cell activation, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of Notch signaling pathway, positive regulation of antibacterial peptide biosynthetic process, positive regulation of autophagy, positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell population proliferation, positive regulation of cytokine production involved in immune response, positive regulation of cytokine production involved in inflammatory response, positive regulation of dendritic cell antigen processing and presentation, positive regulation of dendritic cell cytokine production, positive regulation of epithelial cell proliferation, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of innate immune response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-17 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of macrophage cytokine production, positive regulation of mitophagy, positive regulation of monocyte chemotactic protein-1 production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of phagocytosis, positive regulation of protein K63-linked ubiquitination, positive regulation of protein ubiquitination, positive regulation of stress-activated MAPK cascade, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type 2 immune response, positive regulation of xenophagy, protein K63-linked ubiquitination, protein linear polyubiquitination, regulation of apoptotic process, regulation of appetite, regulation of inflammatory response, regulation of neutrophil chemotaxis, response to endoplasmic reticulum stress, response to exogenous dsRNA, response to lipopolysaccharide, response to muramyl dipeptide, response to peptidoglycan, signal transduction, temperature homeostasis; MF: ADP binding, ATP binding, CARD domain binding, Hsp70 protein binding, Hsp90 protein binding, actin binding, anion binding, carbohydrate derivative binding, enzyme binding, muramyl dipeptide binding, nucleotide binding, pattern recognition receptor activity, peptidoglycan binding, protein binding, protein kinase binding, protein-containing complex binding, ubiquitin binding; CC: Golgi apparatus, basolateral plasma membrane, cell surface, cytoplasm, cytoskeleton, cytosol, extrinsic component of plasma membrane, membrane, mitochondrion, phagocytic vesicle, plasma membrane, protein-containing complex, vesicle
Pathways: Inflammatory bowel disease - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q8K3Z0
Entrez ID: 257632
|
Does Knockout of Klhl3 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Klhl3
|
response to virus
|
Microglial Cell Line
|
Gene: Klhl3 (kelch-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: distal tubule morphogenesis, gene expression, monoatomic ion homeostasis, potassium ion homeostasis, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein catabolic process, protein polyubiquitination, protein ubiquitination, renal absorption, renal sodium ion absorption, ubiquitin-dependent protein catabolic process; MF: actin binding, cullin family protein binding, protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, cytoskeleton, cytosol
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: E0CZ16
Entrez ID: 100503085
|
Does Knockout of Hyi in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Hyi
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hyi (hydroxypyruvate isomerase (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydroxypyruvate isomerase activity, isomerase activity
Pathways: Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse)
UniProt: Q8R1F5
Entrez ID: 68180
|
Does Knockout of Wfikkn2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Wfikkn2
|
phagocytosis
|
macrophage
|
Gene: Wfikkn2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: muscle cell development, negative regulation of transforming growth factor beta receptor signaling pathway, roof of mouth development, skeletal system development, transforming growth factor beta receptor signaling pathway; MF: enzyme inhibitor activity, peptidase inhibitor activity, protein binding, receptor antagonist activity, serine-type endopeptidase inhibitor activity, transforming growth factor beta binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q7TQN3
Entrez ID: 278507
|
Does Knockout of Garem2 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Garem2
|
response to virus
|
Microglial Cell Line
|
Gene: Garem2 (GRB2 associated regulator of MAPK1 subtype 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cognition, neuron projection extension, response to stress, social behavior; MF: molecular_function, protein binding
Pathways:
UniProt: Q6PAJ3
Entrez ID: 242915
|
Does Knockout of Mrpl54 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Mrpl54
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mrpl54 (mitochondrial ribosomal protein L54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CPW3
Entrez ID: 66047
|
Does Knockout of Cetn3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Cetn3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cetn3 (centrin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, mRNA transport, microtubule cytoskeleton organization, protein transport; MF: G-protein beta/gamma-subunit complex binding, calcium ion binding, metal ion binding, microtubule binding; CC: centriole, centrosome, ciliary basal body, ciliary transition zone, cytoplasm, cytoskeleton, microtubule organizing center, nuclear envelope, nuclear pore, nuclear pore nuclear basket, nucleolus, nucleus, photoreceptor connecting cilium, transcription export complex 2
Pathways:
UniProt: O35648
Entrez ID: 12626
|
Does Knockout of Tra2b in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Tra2b
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Tra2b (transformer 2 beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cellular response to glucose stimulus, cerebral cortex regionalization, embryonic brain development, mRNA processing, mRNA splicing, via spliceosome, positive regulation of mRNA splicing, via spliceosome, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, identical protein binding, mRNA binding, nucleic acid binding, poly-purine tract binding, pre-mRNA binding, protein binding, protein domain specific binding; CC: male germ cell nucleus, nuclear inner membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex, spliceosomal complex
Pathways: Alcoholic liver disease - Mus musculus (mouse), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, RHOBTB2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P62996
Entrez ID: 20462
|
Does Knockout of Xkr8 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Xkr8
|
phagocytosis
|
macrophage
|
Gene: Xkr8 (X-linked Kx blood group related 8)
Type: protein-coding
Summary: Enables phospholipid scramblase activity. Involved in apoptotic cell clearance; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of myoblast differentiation. Acts upstream of or within establishment of localization in cell and tolerance induction to self antigen. Is active in plasma membrane. Orthologous to human XKR8 (XK related 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, apoptotic process involved in development, engulfment of apoptotic cell, establishment of localization in cell, neutrophil clearance, phosphatidylserine exposure on apoptotic cell surface, positive regulation of myoblast differentiation, tolerance induction to self antigen; MF: phospholipid scramblase activity; CC: cytoplasm, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q8C0T0
Entrez ID: 381560
|
Does Knockout of Zfp938 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Zfp938
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp938 (zinc finger protein 938)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: D6RJ82, E9Q9G3
Entrez ID: 237411
|
Does Knockout of Ampd2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ampd2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ampd2 (adenosine monophosphate deaminase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMP metabolic process, ATP metabolic process, GMP salvage, GTP metabolic process, IMP biosynthetic process, IMP salvage, cholesterol homeostasis, cyclic purine nucleotide metabolic process, energy homeostasis, nucleotide metabolic process, podocyte development, purine ribonucleoside monophosphate biosynthetic process; MF: AMP deaminase activity, deaminase activity, hydrolase activity, identical protein binding, metal ion binding; CC: cytosol
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide salvage, Purine metabolism - Mus musculus (mouse), Purine salvage
UniProt: Q9DBT5
Entrez ID: 109674
|
Does Knockout of Ccnc in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ccnc
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ccnc (cyclin C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G0 to G1 transition, negative regulation of Notch signaling pathway, negative regulation of triglyceride metabolic process, positive regulation of transcription by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II; MF: cyclin-dependent protein serine/threonine kinase regulator activity, identical protein binding, ubiquitin protein ligase activity; CC: CKM complex, cyclin-dependent protein kinase holoenzyme complex, mediator complex, nucleoplasm, nucleus, protein-containing complex, ubiquitin ligase complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: Q62447
Entrez ID: 51813
|
Does Knockout of Bmpr2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Bmpr2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Bmpr2 (bone morphogenetic protein receptor type 2)
Type: protein-coding
Summary: This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: BMP signaling pathway, MAPK cascade, activin receptor signaling pathway, angiogenesis, anterior/posterior pattern specification, aortic valve development, artery development, atrial septum morphogenesis, atrioventricular valve morphogenesis, blood vessel development, blood vessel remodeling, bone development, cardiac muscle tissue development, cell differentiation, cell fate specification, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to BMP stimulus, cellular response to growth factor stimulus, cellular response to starvation, chondrocyte development, endocardial cushion development, endochondral bone morphogenesis, endothelial cell apoptotic process, endothelial cell proliferation, limb development, lung alveolus development, lung development, lung vasculature development, lymphangiogenesis, lymphatic endothelial cell differentiation, maternal placenta development, mesoderm formation, mitral valve morphogenesis, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of cell proliferation involved in heart valve morphogenesis, negative regulation of chondrocyte proliferation, negative regulation of muscle cell differentiation, negative regulation of smooth muscle cell proliferation, negative regulation of systemic arterial blood pressure, negative regulation of vasoconstriction, osteoblast differentiation, outflow tract morphogenesis, outflow tract septum morphogenesis, pharyngeal arch artery morphogenesis, positive regulation of SMAD protein signal transduction, positive regulation of axon extension involved in axon guidance, positive regulation of bone mineralization, positive regulation of cartilage development, positive regulation of cell differentiation, positive regulation of epithelial cell migration, positive regulation of gene expression, positive regulation of locomotion, positive regulation of ossification, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, protein import into nucleus, proteoglycan biosynthetic process, pulmonary valve development, regulation of cell growth, regulation of cell population proliferation, regulation of lung blood pressure, regulation of multicellular organismal development, retina development in camera-type eye, retina vasculature development in camera-type eye, semi-lunar valve development, stem cell differentiation, tissue development, tricuspid valve morphogenesis, vasculature development, venous blood vessel development, ventricular septum morphogenesis; MF: ATP binding, BMP binding, BMP receptor activity, activin receptor activity, type II, cadherin binding, growth factor binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase binding, transferase activity, transforming growth factor beta receptor activity, transmembrane receptor protein serine/threonine kinase activity; CC: adherens junction, apical plasma membrane, axon, basal plasma membrane, caveola, cell body, cell junction, cell surface, clathrin-coated pit, dendrite, membrane, neuronal cell body, nucleoplasm, organelle, plasma membrane, postsynaptic density, receptor complex
Pathways: Axon guidance - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Signal Transduction, Signaling by BMP, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: O35607
Entrez ID: 12168
|
Does Knockout of Pomt2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,685
|
Knockout
|
Pomt2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pomt2 (protein-O-mannosyltransferase 2)
Type: protein-coding
Summary: This gene encodes an integral membrane protein that belongs to the dolichyl-phosphate-mannose-protein mannosyltransferase family. The encoded enzyme is found in the membrane of the endoplasmic reticulum. This protein is a component of the protein O-mannosyltransferase enzyme complex which is involved in modification of the protein alpha-dystroglycan. Mutations in the human gene are a cause of different forms of muscular dystrophy-dystroglycanopathy (MDDG), type A2 (also known as Walker-Warburg syndrome), type B2 and type C2 (also known as limb-girdle muscular dystrophy). [provided by RefSeq, Sep 2015].
Gene Ontology: BP: basement membrane organization, dentate gyrus development, protein O-linked glycosylation, protein O-linked glycosylation via mannose, protein glycosylation, reactive gliosis; MF: dolichyl-phosphate-mannose-protein mannosyltransferase activity, glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: cytosol, dolichyl-phosphate-mannose-protein mannosyltransferase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus, nucleoplasm
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, DAG1 core M1 glycosylations, DAG1 core M2 glycosylations, DAG1 core M3 glycosylations, DAG1 glycosylations, Mannose type O-glycan biosynthesis - Mus musculus (mouse), Metabolism of proteins, O-linked glycosylation, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q8BGQ4
Entrez ID: 217734
|
Does Knockout of Wbp11 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Wbp11
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Wbp11 (WW domain binding protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, rRNA processing; MF: WW domain binding, protein binding, protein phosphatase regulator activity; CC: cytoplasm, cytosol, nuclear speck, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q923D5
Entrez ID: 60321
|
Does Knockout of Col17a1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,663
|
Knockout
|
Col17a1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Col17a1 (collagen, type XVII, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hemidesmosome assembly; MF: extracellular matrix structural constituent conferring tensile strength, protein binding; CC: anchoring junction, basement membrane, collagen trimer, extracellular matrix, extracellular region, hemidesmosome, membrane
Pathways: Adaptive Immune System, Cell junction organization, Cell-Cell communication, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen formation, Extracellular matrix organization, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Protein digestion and absorption - Mus musculus (mouse), Type I hemidesmosome assembly
UniProt: Q07563
Entrez ID: 12821
|
Does Knockout of Zfp518b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Zfp518b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp518b (zinc finger protein 518B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding
Pathways:
UniProt: J3QNM2, J3QPN0, J3QNT5
Entrez ID: 100515
|
Does Knockout of Pth2r in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Pth2r
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pth2r (parathyroid hormone 2 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, positive regulation of cold-induced thermogenesis, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, parathyroid hormone receptor activity, peptide hormone binding, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q91V95
Entrez ID: 213527
|
Does Knockout of Vmn1r229 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Vmn1r229
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Vmn1r229 (vomeronasal 1 receptor 229)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R2A9
Entrez ID: 171224
|
Does Knockout of Plp2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Plp2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Plp2 (proteolipid protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: chemokine binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9R1Q7
Entrez ID: 18824
|
Does Knockout of Adam34 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Adam34
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Adam34 (a disintegrin and metallopeptidase domain 34)
Type: protein-coding
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Is expressed in seminiferous tubule and testis. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: integrin-mediated signaling pathway, male gonad development, proteolysis; MF: metal ion binding, metalloendopeptidase activity, metallopeptidase activity, molecular_function; CC: external side of plasma membrane, membrane, plasma membrane, sperm head plasma membrane
Pathways:
UniProt: A2RSG8
Entrez ID: 252866
|
Does Knockout of Aqp8 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Aqp8
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Aqp8 (aquaporin 8)
Type: protein-coding
Summary: Enables ammonium channel activity; urea channel activity; and water channel activity. Involved in several processes, including ammonium import across plasma membrane; hydrogen peroxide transmembrane transport; and urea transport. Located in several cellular components, including intracellular canaliculus; mitochondrion; and smooth endoplasmic reticulum. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; liver; and submandibular gland primordium. Orthologous to human AQP8 (aquaporin 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell differentiation, ammonium import across plasma membrane, ammonium transmembrane transport, canalicular bile acid transport, cellular detoxification, cellular response to cAMP, hydrogen peroxide transmembrane transport, methylammonium transmembrane transport, methylammonium transport, one-carbon compound transport, regulation of cholesterol biosynthetic process, transepithelial water transport, transmembrane transport, urea transmembrane transport, urea transport, water transport; MF: ammonium channel activity, channel activity, methylammonium channel activity, urea channel activity, water channel activity; CC: apical part of cell, apical plasma membrane, basolateral plasma membrane, brush border membrane, endoplasmic reticulum, intracellular canaliculus, intracellular vesicle, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, plasma membrane, smooth endoplasmic reticulum, smooth endoplasmic reticulum membrane
Pathways: Aquaporin-mediated transport, Bile secretion - Mus musculus (mouse), Passive transport by Aquaporins, Transport of small molecules
UniProt: P56404
Entrez ID: 11833
|
Does Knockout of Hipk2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Hipk2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Hipk2 (homeodomain interacting protein kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, SMAD protein signal transduction, adult locomotory behavior, adult walking behavior, anterior/posterior pattern specification, apoptotic process, embryonic camera-type eye morphogenesis, embryonic retina morphogenesis in camera-type eye, gene expression, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, iris morphogenesis, lens induction in camera-type eye, lung morphogenesis, negative regulation of BMP signaling pathway, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, neuron differentiation, positive regulation of DNA binding, positive regulation of JNK cascade, positive regulation of angiogenesis, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, protein phosphorylation, respiratory system process, retina layer formation, smoothened signaling pathway, thyroid gland development, transforming growth factor beta receptor signaling pathway, voluntary musculoskeletal movement; MF: ATP binding, DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, SMAD binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transcription coactivator activity, transcription corepressor activity, transferase activity, virion binding; CC: PML body, RNA polymerase II transcription regulator complex, cytoplasm, cytoplasmic stress granule, nuclear body, nucleoplasm, nucleus, protein-containing complex
Pathways: Cellular senescence - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Regulation of MECP2 expression and activity, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Transcriptional Regulation by MECP2, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1
UniProt: Q9QZR5
Entrez ID: 15258
|
Does Knockout of Arfip1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Arfip1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Arfip1 (ARF interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein localization, intracellular protein transport, negative regulation of retrograde transport, endosome to Golgi, regulation of Arp2/3 complex-mediated actin nucleation, regulation of protein secretion; MF: phosphatidylinositol-4-phosphate binding, phospholipid binding, protein domain specific binding; CC: Golgi apparatus, Golgi membrane, cytosol, membrane, trans-Golgi network membrane
Pathways:
UniProt: G5E8V9
Entrez ID: 99889
|
Does Knockout of Ripor3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Ripor3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ripor3 (RIPOR family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A1L3T7
Entrez ID: 69553
|
Does Knockout of Acat2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Acat2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Acat2 (acetyl-Coenzyme A acetyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, fatty acid metabolic process, isopentenyl diphosphate biosynthetic process, mevalonate pathway, zymosterol biosynthetic process; MF: acetyl-CoA C-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, transferase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: 2-methylbutyrate biosynthesis, Butanoate metabolism - Mus musculus (mouse), Cholesterol biosynthesis, Fat digestion and absorption - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of steroids, Pyruvate metabolism - Mus musculus (mouse), Terpenoid backbone biosynthesis - Mus musculus (mouse), Tryptophan metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), acetoacetate degradation (to acetyl CoA), glutaryl-CoA degradation, isoleucine degradation, ketogenesis, ketolysis, ketone oxidation, mevalonate pathway I, superpathway of cholesterol biosynthesis, tryptophan degradation III (eukaryotic)
UniProt: Q8CAY6
Entrez ID: 110460
|
Does Knockout of Bbs12 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Bbs12
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Bbs12 (Bardet-Biedl syndrome 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated protein complex assembly, eating behavior, intraciliary transport, negative regulation of fat cell differentiation, negative regulation of stem cell differentiation, photoreceptor cell maintenance; CC: cell projection, cilium
Pathways:
UniProt: Q5SUD9
Entrez ID: 241950
|
Does Knockout of Atp6v1b2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,263
|
Knockout
|
Atp6v1b2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Atp6v1b2 (ATPase, H+ transporting, lysosomal V1 subunit B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification, vacuolar acidification; MF: ATP binding, nucleotide binding, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, extrinsic component of synaptic vesicle membrane, melanosome, membrane, microvillus, myelin sheath, plasma membrane, proton-transporting V-type ATPase, V1 domain, ruffle, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: P62814
Entrez ID: 11966
|
Does Knockout of Unc93b1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Unc93b1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Unc93b1 (unc-93 homolog B1, TLR signaling regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell antigen processing and presentation, adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, cell morphogenesis, defense response to virus, immune system process, innate immune response, intracellular protein transport, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, toll-like receptor 3 signaling pathway, toll-like receptor 7 signaling pathway, toll-like receptor 9 signaling pathway, toll-like receptor signaling pathway; MF: Toll-like receptor binding, protein binding; CC: cytoplasmic vesicle, early phagosome, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, lysosome, membrane, phagocytic vesicle
Pathways: Immune System, Innate Immune System, Toll-like Receptor Cascades, Trafficking and processing of endosomal TLR
UniProt: Q8VCW4
Entrez ID: 54445
|
Does Knockout of Pip4k2a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Pip4k2a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pip4k2a (phosphatidylinositol-5-phosphate 4-kinase, type II, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process, autophagosome-lysosome fusion, lipid metabolic process, megakaryocyte development, negative regulation of insulin receptor signaling pathway, phosphatidylinositol metabolic process, phosphatidylinositol phosphate biosynthetic process, positive regulation of autophagosome assembly, regulation of autophagy, vesicle-mediated cholesterol transport; MF: 1-phosphatidylinositol-4-phosphate 5-kinase activity, 1-phosphatidylinositol-5-phosphate 4-kinase activity, ATP binding, kinase activity, nucleotide binding, phosphatidylinositol kinase activity, protein binding, protein homodimerization activity, transferase activity; CC: autophagosome, cell projection, cytoplasm, cytosol, lysosome, membrane, nucleus, photoreceptor inner segment, photoreceptor outer segment, plasma membrane
Pathways: D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, Gene expression (Transcription), Generic Transcription Pathway, Inositol phosphate metabolism - Mus musculus (mouse), Intracellular signaling by second messengers, Metabolism, Metabolism of lipids, Negative regulation of the PI3K/AKT network, PI Metabolism, PI5P Regulates TP53 Acetylation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP metabolism, PIP3 activates AKT signaling, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Synthesis of PIPs at the plasma membrane, Synthesis of PIPs in the nucleus, Transcriptional Regulation by TP53
UniProt: O70172
Entrez ID: 18718
|
Does Knockout of Mthfd2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Mthfd2
|
cell proliferation
|
Regulatory T cell
|
Gene: Mthfd2 (methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carboxylic acid metabolic process, formate biosynthetic process, one-carbon metabolic process, tetrahydrofolate interconversion, tetrahydrofolate metabolic process; MF: catalytic activity, hydrolase activity, magnesium ion binding, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, oxidoreductase activity, phosphate ion binding; CC: mitochondrial matrix, mitochondrion
Pathways: Metabolism, Metabolism of folate and pterines, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, One carbon pool by folate - Mus musculus (mouse), folate transformations I, folate transformations II (plants), histidine degradation III, tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate
UniProt: P18155
Entrez ID: 17768
|
Does Knockout of Arhgef12 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Arhgef12
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arhgef12 (Rho guanine nucleotide exchange factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho protein signal transduction, Rho-activating G protein-coupled receptor signaling pathway, intracellular signal transduction, regulation of blood pressure; MF: G protein-coupled receptor binding, GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding; CC: cytoplasm, membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), CDC42 GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, Developmental Biology, G alpha (12/13) signalling events, GPCR downstream signalling, Human cytomegalovirus infection - Mus musculus (mouse), NRAGE signals death through JNK, Nervous system development, Pathways in cancer - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tuberculosis - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cyclic AMP biosynthesis, p75 NTR receptor-mediated signalling
UniProt: Q8R4H2
Entrez ID: 69632
|
Does Knockout of Acy1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Acy1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Acy1 (aminoacylase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid metabolic process, protein catabolic process; MF: aminoacylase activity, hydrolase activity, identical protein binding, metal ion binding; CC: cytoplasm, extracellular exosome
Pathways: Aflatoxin activation and detoxification, Arginine biosynthesis - Mus musculus (mouse), Biological oxidations, Drug ADME, Metabolism, Paracetamol ADME
UniProt: Q99JW2
Entrez ID: 109652
|
Does Knockout of Rpl19 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rpl19
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rpl19 (ribosomal protein L19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation; MF: 5.8S rRNA binding, RNA binding, large ribosomal subunit rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleolus, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P84099
Entrez ID: 19921
|
Does Knockout of Mss51 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Mss51
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mss51 (MSS51 mitochondrial translational activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q9D5Z5
Entrez ID: 74843
|
Does Knockout of Helb in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Helb
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Helb (helicase (DNA) B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA replication, DNA replication, synthesis of primer, DNA-templated DNA replication, negative regulation of double-strand break repair via homologous recombination, regulation of DNA double-strand break processing; MF: 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA helicase activity, helicase activity, hydrolase activity, nucleotide binding, protein-containing complex binding, single-stranded DNA helicase activity; CC: DNA replication factor A complex, chromosome, cytoplasm, cytosol, mitochondrion, nuclear body, nucleoplasm, nucleus, site of double-strand break
Pathways:
UniProt: Q6NVF4
Entrez ID: 117599
|
Does Knockout of Map4k4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Map4k4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Map4k4 (mitogen-activated protein kinase kinase kinase kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, hippo signaling, intracellular signal transduction, negative regulation of apoptotic process, negative regulation of insulin secretion involved in cellular response to glucose stimulus, negative regulation of neuron projection development, negative regulation of neuron projection regeneration, neuron projection morphogenesis, positive regulation of ARF protein signal transduction, positive regulation of JNK cascade, positive regulation of cell migration, positive regulation of focal adhesion assembly, positive regulation of focal adhesion disassembly, positive regulation of hippo signaling, positive regulation of keratinocyte migration, protein phosphorylation, regulation of JNK cascade, regulation of MAPK cascade; MF: ATP binding, MAP kinase kinase kinase kinase activity, creatine kinase activity, kinase activity, microtubule binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, focal adhesion
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, MAPK signaling pathway - Mus musculus (mouse), Oxidative Stress Induced Senescence
UniProt: P97820
Entrez ID: 26921
|
Does Knockout of Prg3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Prg3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prg3 (proteoglycan 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: basophil activation, histamine biosynthetic process, immune response, leukotriene biosynthetic process, negative regulation of translation, neutrophil activation, positive regulation of interleukin-8 production, superoxide anion generation
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q9JL95
Entrez ID: 53856
|
Does Knockout of Aurkc in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Aurkc
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Aurkc (aurora kinase C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, meiotic cell cycle, mitotic spindle organization, protein phosphorylation, regulation of cytokinesis; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, chromosome, chromosome passenger complex, chromosome, centromeric region, condensed chromosome, cytoplasm, cytoskeleton, kinetochore, meiotic spindle midzone, midbody, nucleus, spindle, spindle microtubule, spindle midzone, spindle pole
Pathways:
UniProt: O88445
Entrez ID: 20871
|
Does Knockout of Tmem106c in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Tmem106c
|
response to bacteria
|
renal medulla cell line
|
Gene: Tmem106c (transmembrane protein 106C)
Type: protein-coding
Summary: Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including brain and retina. Orthologous to human TMEM106C (transmembrane protein 106C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q80VP8
Entrez ID: 380967
|
Does Knockout of Nap1l4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Nap1l4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nap1l4 (nucleosome assembly protein 1-like 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly; MF: chromatin binding, histone binding, nucleosome binding; CC: chromatin, cytoplasm, dendrite, neuronal cell body, nucleus
Pathways:
UniProt: Q78ZA7
Entrez ID: 17955
|
Does Knockout of Tubd1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Tubd1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tubd1 (tubulin, delta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle, positive regulation of smoothened signaling pathway; MF: GTP binding, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: cell projection, centriole, cilium, cytoplasm, cytoskeleton, cytosol, microtubule, nucleoplasm, nucleus
Pathways:
UniProt: Q9R1K7
Entrez ID: 56427
|
Does Knockout of Cbr1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Cbr1
|
cell proliferation
|
Regulatory T cell
|
Gene: Cbr1 (carbonyl reductase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucocorticoid metabolic process, lipid metabolic process, phylloquinone catabolic process, positive regulation of reactive oxygen species metabolic process, prostaglandin catabolic process, response to estradiol, response to progesterone, steroid catabolic process, vitamin K metabolic process, xenobiotic metabolic process; MF: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity, 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, S-nitrosoglutathione reductase (NADPH) activity, alcohol dehydrogenase (NADP+) activity, carbonyl reductase (NADPH) activity, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, prostaglandin E2 9-reductase activity; CC: cytoplasm, microvillus
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Fatty acid metabolism, Folate biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
UniProt: P48758
Entrez ID: 12408
|
Does Knockout of Ampd3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ampd3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ampd3 (adenosine monophosphate deaminase 3)
Type: protein-coding
Summary: This gene encodes a member of the adenosine and AMP deaminases family. The encoded protein is an AMP deaminase involved in nucleotide and energy metabolism in erythrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: ADP catabolic process, ADP metabolic process, AMP catabolic process, AMP metabolic process, ATP metabolic process, GTP metabolic process, IMP biosynthetic process, IMP salvage, energy homeostasis, erythrocyte homeostasis, nucleotide metabolic process, purine ribonucleoside monophosphate biosynthetic process; MF: AMP deaminase activity, deaminase activity, hydrolase activity, metal ion binding
Pathways: Immune System, Innate Immune System, Metabolism, Metabolism of nucleotides, Neutrophil degranulation, Nucleotide salvage, Purine metabolism - Mus musculus (mouse), Purine salvage
UniProt: O08739
Entrez ID: 11717
|
Does Knockout of Crtc2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Crtc2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Crtc2 (CREB regulated transcription coactivator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to cAMP, gluconeogenesis, glucose homeostasis, positive regulation of CREB transcription factor activity, positive regulation of transcription by RNA polymerase II, protein homotetramerization; MF: cAMP response element binding protein binding, chromatin binding, protein binding, transcription coactivator activity; CC: cytoplasm, nucleoplasm, nucleus
Pathways: AMPK signaling pathway - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse)
UniProt: Q3U182
Entrez ID: 74343
|
Does Knockout of Foxk1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Foxk1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Foxk1 (forkhead box K1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, cell differentiation, intracellular glucose homeostasis, muscle organ development, negative regulation of DNA-templated transcription, negative regulation of autophagy, negative regulation of cell cycle, negative regulation of cell growth, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of glucose metabolic process, regulation of transcription by RNA polymerase II, response to starvation; MF: 14-3-3 protein binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: cytoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, UCH proteinases
UniProt: P42128
Entrez ID: 17425
|
Does Knockout of Drd3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Drd3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Drd3 (dopamine receptor D3)
Type: protein-coding
Summary: Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in behavioral response to cocaine and regulation of neurotransmitter uptake. Acts upstream of or within several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; regulation of blood pressure; and regulation of dopamine receptor signaling pathway. Located in plasma membrane. Is active in dopaminergic synapse. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and sensory organ. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor internalization, G protein-coupled receptor signaling pathway, acid secretion, adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-inhibiting dopamine receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, arachidonate secretion, autophagy, behavioral response to cocaine, circadian regulation of gene expression, intracellular calcium ion homeostasis, locomotory behavior, musculoskeletal movement, spinal reflex action, negative regulation of G protein-coupled receptor signaling pathway, negative regulation of apoptotic process, negative regulation of blood pressure, negative regulation of cytosolic calcium ion concentration, negative regulation of dopamine receptor signaling pathway, negative regulation of oligodendrocyte differentiation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of protein secretion, negative regulation of synaptic transmission, glutamatergic, negative regulation of transcription by RNA polymerase II, phospholipase C-activating dopamine receptor signaling pathway, positive regulation of cell population proliferation, positive regulation of cytokinesis, positive regulation of dopamine receptor signaling pathway, positive regulation of mitotic nuclear division, positive regulation of transcription by RNA polymerase II, prepulse inhibition, regulation of biological quality, regulation of blood volume by renin-angiotensin, regulation of circadian sleep/wake cycle, sleep, regulation of dopamine secretion, regulation of gene expression, regulation of lipid metabolic process, regulation of locomotion involved in locomotory behavior, regulation of multicellular organism growth, regulation of multicellular organismal process, regulation of neurotransmitter uptake, regulation of postsynaptic neurotransmitter receptor internalization, regulation of potassium ion transport, regulation of primary metabolic process, response to amphetamine, response to cocaine, response to ethanol, response to histamine, response to morphine, response to xenobiotic stimulus, signal transduction, synaptic transmission, dopaminergic, visual learning; MF: D1 dopamine receptor binding, G protein-coupled receptor activity, dopamine neurotransmitter receptor activity, dopamine neurotransmitter receptor activity, coupled via Gi/Go, protein binding, protein domain specific binding; CC: GABA-ergic synapse, apical part of cell, cell projection, dopaminergic synapse, endocytic vesicle, glutamatergic synapse, membrane, plasma membrane, postsynaptic density membrane, synapse
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), Dopamine receptors, Dopaminergic synapse - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P30728
Entrez ID: 13490
|
Does Knockout of Cttnbp2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Cttnbp2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cttnbp2 (cortactin binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of modification of postsynaptic actin cytoskeleton, regulation of synapse organization; MF: SH3 domain binding, protein binding; CC: FAR/SIN/STRIPAK complex, cell cortex, cell projection, cytoplasm, dendritic spine, glutamatergic synapse, postsynaptic actin cytoskeleton, synapse, synaptic vesicle
Pathways:
UniProt: B9EJA2
Entrez ID: 30785
|
Does Knockout of Slc26a4 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Slc26a4
|
cell proliferation
|
Regulatory T cell
|
Gene: Slc26a4 (solute carrier family 26, member 4)
Type: protein-coding
Summary: Enables chloride:bicarbonate antiporter activity. Involved in regulation of pH and regulation of protein localization. Located in apical plasma membrane and brush border membrane. Is expressed in central nervous system; inner ear; and metanephros. Used to study Pendred Syndrome. Human ortholog(s) of this gene implicated in Pendred Syndrome; autosomal recessive nonsyndromic deafness 4; and goiter. Orthologous to human SLC26A4 (solute carrier family 26 member 4). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: animal organ morphogenesis, chloride transmembrane transport, inorganic anion transport, iodide transport, oxalate transport, regulation of pH, regulation of protein localization, sulfate transmembrane transport, transmembrane transport; MF: chloride transmembrane transporter activity, chloride:bicarbonate antiporter activity, iodide transmembrane transporter activity, monoatomic anion transmembrane transporter activity, oxalate transmembrane transporter activity, protein binding, secondary active sulfate transmembrane transporter activity, sulfate transmembrane transporter activity; CC: apical plasma membrane, brush border membrane, extracellular exosome, membrane, plasma membrane
Pathways: Inorganic anion exchange by SLC26 transporters, SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Thyroid hormone synthesis - Mus musculus (mouse), Transport of small molecules
UniProt: Q9R155
Entrez ID: 23985
|
Does Knockout of Tec in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Tec
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tec (tec protein tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell receptor signaling pathway, T cell receptor signaling pathway, adaptive immune response, immune system process, integrin-mediated signaling pathway, intracellular signal transduction, regulation of platelet activation; MF: ATP binding, kinase activity, lipid binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, zinc ion binding; CC: cell-cell junction, cytoplasm, cytoskeleton, cytosol, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, FCERI mediated Ca+2 mobilization, Fc epsilon receptor (FCERI) signaling, Immune System, Innate Immune System, Interleukin-3, Interleukin-5 and GM-CSF signaling, Osteoclast differentiation - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, T cell receptor signaling pathway - Mus musculus (mouse)
UniProt: P24604
Entrez ID: 21682
|
Does Knockout of Golim4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Golim4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Golim4 (golgi integral membrane protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, endosome, endosome membrane, membrane
Pathways:
UniProt: Q8BXA1
Entrez ID: 73124
|
Does Knockout of Lsp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Lsp1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lsp1 (lymphocyte specific 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to interleukin-7, chemotaxis, cytoskeleton organization, defense response, signal transduction; MF: actin binding; CC: membrane, plasma membrane
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: P19973
Entrez ID: 16985
|
Does Knockout of Ccdc182 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Ccdc182
|
phagocytosis
|
macrophage
|
Gene: Ccdc182 (coiled-coil domain containing 182)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, female gonad development
Pathways:
UniProt: Q9D9C6
Entrez ID: 74297
|
Does Knockout of Nol8 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Nol8
|
response to bacteria
|
renal medulla cell line
|
Gene: Nol8 (nucleolar protein 8)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in chromosome. Predicted to be active in nucleolus. Is expressed in central nervous system and sensory organ. Orthologous to human NOL8 (nucleolar protein 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to leukemia inhibitory factor, protein localization to nucleolus, rRNA processing; MF: RNA binding, nucleic acid binding; CC: chromosome, nucleolus, nucleus
Pathways:
UniProt: Q3UHX0
Entrez ID: 70930
|
Does Knockout of Pnpla1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Pnpla1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pnpla1 (patatin-like phospholipase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, establishment of skin barrier, keratinocyte differentiation, lipid catabolic process, lipid homeostasis, lipid metabolic process, omega-hydroxyceramide biosynthetic process, triglyceride catabolic process; MF: acyltransferase activity, transferring groups other than amino-acyl groups, hydrolase activity, omega-hydroxyceramide transacylase activity, structural constituent of skin epidermis, transferase activity, triacylglycerol lipase activity; CC: cytoplasm, lipid droplet, membrane
Pathways:
UniProt: Q3V1D5
Entrez ID: 433091
|
Does Knockout of Gm9905 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Gm9905
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Gm9905 (predicted gene 9905)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Fktn in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Fktn
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Fktn (fukutin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: basement membrane organization, brain development, cerebellar cortex development, cerebral cortex development, glycoprotein metabolic process, negative regulation of JNK cascade, negative regulation of cell population proliferation, neuron migration, protein O-linked glycosylation, protein O-linked glycosylation via mannose, protein glycosylation, skeletal muscle fiber differentiation; MF: phosphotransferase activity, for other substituted phosphate groups, transferase activity; CC: Golgi apparatus, Golgi membrane, cis-Golgi network, cytoplasm, endoplasmic reticulum, membrane, nucleus
Pathways: DAG1 glycosylations, Mannose type O-glycan biosynthesis - Mus musculus (mouse), Matriglycan biosynthesis on DAG1, Metabolism of proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8R507
Entrez ID: 246179
|
Does Knockout of Stat5b in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Stat5b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Stat5b (signal transducer and activator of transcription 5B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, Peyer's patch development, T cell differentiation in thymus, T cell homeostasis, activated T cell proliferation, acute-phase response, cell surface receptor signaling pathway via JAK-STAT, cellular response to epidermal growth factor stimulus, cellular response to growth factor stimulus, cellular response to hormone stimulus, cytokine-mediated signaling pathway, defense response, development of secondary female sexual characteristics, development of secondary male sexual characteristics, erythrocyte differentiation, erythropoietin-mediated signaling pathway, female pregnancy, gamma-delta T cell differentiation, growth hormone receptor signaling pathway via JAK-STAT, lactation, lipid storage, liver development, luteinization, mast cell migration, myeloid cell apoptotic process, natural killer cell differentiation, natural killer cell mediated cytotoxicity, negative regulation of erythrocyte differentiation, negative regulation of myeloid cell apoptotic process, positive regulation of B cell differentiation, positive regulation of activated T cell proliferation, positive regulation of cell population proliferation, positive regulation of erythrocyte differentiation, positive regulation of fibroblast growth factor production, positive regulation of gamma-delta T cell differentiation, positive regulation of gene expression, positive regulation of inflammatory response, positive regulation of interleukin-2 production, positive regulation of lymphocyte differentiation, positive regulation of mitotic cell cycle, positive regulation of multicellular organism growth, positive regulation of natural killer cell differentiation, positive regulation of natural killer cell mediated cytotoxicity, positive regulation of natural killer cell proliferation, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, progesterone metabolic process, regulation of DNA-templated transcription, regulation of cell adhesion, regulation of cell population proliferation, regulation of epithelial cell differentiation, regulation of multicellular organism growth, regulation of steroid metabolic process, regulation of transcription by RNA polymerase II, response to estradiol, response to interleukin-15, response to interleukin-2, response to interleukin-4, response to lipopolysaccharide, response to peptide hormone, sex differentiation, signal transduction, taurine metabolic process, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, double-stranded DNA binding, identical protein binding, nuclear glucocorticoid receptor binding, protein binding, protein dimerization activity, protein homodimerization activity, sequence-specific DNA binding; CC: RNA polymerase II transcription regulator complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Cytokine Signaling in Immune system, Downstream signal transduction, ErbB signaling pathway - Mus musculus (mouse), Growth hormone receptor signaling, Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Interleukin-15 signaling, Interleukin-2 family signaling, Interleukin-2 signaling, Interleukin-20 family signaling, Interleukin-21 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-7 signaling, Interleukin-9 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P42232
Entrez ID: 20851
|
Does Knockout of Fer1l4 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Fer1l4
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Fer1l4 (fer-1 like family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function; CC: cellular_component, membrane
Pathways:
UniProt: F6YZT0, Z4YL23, F6UNQ3
Entrez ID: 74562
|
Does Knockout of Ankrd60 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Ankrd60
|
cell proliferation
|
Regulatory T cell
|
Gene: Ankrd60 (ankyrin repeat domain 60)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2AMD2, A0A6I8MWY2, A6PWV4
Entrez ID: 70065
|
Does Knockout of Tmem176b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Tmem176b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tmem176b (transmembrane protein 176B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of dendritic cell differentiation; CC: membrane, nuclear membrane, nucleus
Pathways:
UniProt: Q9R1Q6
Entrez ID: 65963
|
Does Knockout of 2300009A05Rik in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
2300009A05Rik
|
cell cycle progression
|
breast epithelium
|
Gene: 2300009A05Rik (RIKEN cDNA 2300009A05 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: Q0VG49
Entrez ID: 69478
|
Does Knockout of Sult1c1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Sult1c1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sult1c1 (sulfotransferase family, cytosolic, 1C, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate metabolic process, sulfation, sulfur compound metabolic process, xenobiotic metabolic process; MF: 3'-phosphoadenosine 5'-phosphosulfate binding, alcohol sulfotransferase activity, aryl sulfotransferase activity, bile-salt sulfotransferase activity, sulfotransferase activity, transferase activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q80VR3
Entrez ID: 20888
|
Does Knockout of Elovl6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Elovl6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Elovl6 (ELOVL fatty acid elongase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid elongation, fatty acid elongation, monounsaturated fatty acid, fatty acid elongation, polyunsaturated fatty acid, fatty acid elongation, saturated fatty acid, fatty acid metabolic process, lipid biosynthetic process, lipid metabolic process, long-chain fatty acid biosynthetic process, long-chain fatty-acyl-CoA biosynthetic process, positive regulation of cold-induced thermogenesis, sphingolipid biosynthetic process, unsaturated fatty acid biosynthetic process, very long-chain fatty acid biosynthetic process; MF: acyltransferase activity, transferring groups other than amino-acyl groups, fatty acid elongase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, fatty acid elongase complex, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs
UniProt: Q920L5
Entrez ID: 170439
|
Does Knockout of Cyp1b1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Cyp1b1
|
cell proliferation
|
Regulatory T cell
|
Gene: Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA modification, angiogenesis, arachidonate metabolic process, benzene-containing compound metabolic process, blood vessel endothelial cell migration, blood vessel morphogenesis, cell adhesion, cellular response to hydrogen peroxide, cellular response to toxic substance, collagen fibril organization, endothelial cell migration, endothelial cell-cell adhesion, estrogen metabolic process, fatty acid metabolic process, intrinsic apoptotic signaling pathway in response to oxidative stress, lipid metabolic process, membrane lipid catabolic process, negative regulation of NF-kappaB transcription factor activity, negative regulation of cell adhesion mediated by integrin, negative regulation of cell migration, negative regulation of cell population proliferation, nitric oxide biosynthetic process, positive regulation of DNA biosynthetic process, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of reactive oxygen species metabolic process, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of smooth muscle cell migration, positive regulation of translation, positive regulation of vascular endothelial growth factor production, regulation of reactive oxygen species metabolic process, response to toxic substance, retina vasculature development in camera-type eye, retinal blood vessel morphogenesis, retinal metabolic process, retinol metabolic process, steroid catabolic process, steroid metabolic process, toxin metabolic process, trabecular meshwork development, xenobiotic catabolic process, xenobiotic metabolic process; MF: estrogen 16-alpha-hydroxylase activity, estrogen 2-hydroxylase activity, heme binding, hydroperoxy icosatetraenoate dehydratase activity, iron ion binding, lyase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, steroid hydroxylase activity, testosterone 6-beta-hydroxylase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion
Pathways: Arachidonate metabolism, Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cytochrome P450 - arranged by substrate type, Endogenous sterols, Fatty acid metabolism, Metabolism, Metabolism of lipids, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Phase I - Functionalization of compounds, Steroid hormone biosynthesis - Mus musculus (mouse), Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE), Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET), Tryptophan metabolism - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q64429
Entrez ID: 13078
|
Does Knockout of Tmem256 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Tmem256
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmem256 (transmembrane protein 256)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, mitochondrial inner membrane
Pathways:
UniProt: Q5F285
Entrez ID: 69186
|
Does Knockout of Zfp711 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Zfp711
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp711 (zinc finger protein 711)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 97. Orthologous to human ZNF711 (zinc finger protein 711). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: germ cell development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8BYM9, F8WGY3, E9PUP8, F6VDX0
Entrez ID: 245595
|
Does Knockout of En2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
En2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: En2 (engrailed 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central nervous system neuron differentiation, dopaminergic neuron differentiation, embryonic brain development, hindbrain development, midbrain development, negative regulation of neuron apoptotic process, neuron development, neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: P09066
Entrez ID: 13799
|
Does Knockout of Slc12a8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Slc12a8
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc12a8 (solute carrier family 12 (potassium/chloride transporters), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell volume homeostasis, chloride ion homeostasis, chloride transmembrane transport, inorganic cation transmembrane transport, metal ion transport, monoatomic ion transport, potassium ion homeostasis, potassium ion import across plasma membrane, potassium ion transport, transmembrane transport; MF: chloride:monoatomic cation symporter activity, potassium:chloride symporter activity, symporter activity
Pathways:
UniProt: Q8VI23
Entrez ID: 171286
|
Does Knockout of Btbd35f20 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Btbd35f20
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Btbd35f20 (BTB domain containing 35, family member 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, germ cell development
Pathways:
UniProt: A2CG71
Entrez ID: 668963
|
Does Knockout of Abcc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Abcc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Abcc1 (ATP-binding cassette, sub-family C member 1)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: NK T cell activation, amygdala development, amyloid-beta clearance, amyloid-beta metabolic process, antigen processing and presentation of lipid antigen via MHC class Ib, astrocyte differentiation, bilirubin transport, blood vessel diameter maintenance, carboxylic acid transmembrane transport, cell chemotaxis, cell redox homeostasis, cellular response to amyloid-beta, cellular response to type II interferon, cobalamin transport, cyclic nucleotide transport, defense response to Gram-positive bacterium, endothelial cell apoptotic process, endothelium development, establishment of localization in cell, exploration behavior, export across plasma membrane, export from cell, gene expression, glial cell differentiation, glucocorticoid metabolic process, glutathione metabolic process, glutathione transmembrane transport, granuloma formation, hippocampus development, hydrogen peroxide biosynthetic process, immune response, inflammatory response, inflammatory response to antigenic stimulus, intracellular chemical homeostasis, intracellular nitrogen homeostasis, leukotriene biosynthetic process, leukotriene metabolic process, leukotriene transport, lipid transport, long-chain fatty acid import across plasma membrane, lymphocyte migration, macrophage activation, memory, multicellular organism growth, neural tissue regeneration, neurogenesis, phospholipid efflux, phospholipid translocation, pigment accumulation, positive regulation of cell migration, positive regulation of inflammatory response, protein localization to cell surface, reactive oxygen species biosynthetic process, regulation of cellular response to drug, regulation of membrane potential, response to fluid shear stress, response to glucocorticoid, response to oxidative stress, response to toxic substance, response to type II interferon, response to xenobiotic stimulus, sphingolipid translocation, superoxide anion generation, tissue homeostasis, transepithelial transport, transmembrane transport, xenobiotic detoxification by transmembrane export across the plasma membrane, xenobiotic transmembrane transport, xenobiotic transport, xenobiotic transport across blood-brain barrier; MF: ABC-type glutathione S-conjugate transporter activity, ABC-type transporter activity, ABC-type vitamin B12 transporter activity, ABC-type xenobiotic transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled carboxylic acid transmembrane transporter activity, ATPase-coupled lipid transmembrane transporter activity, amide transmembrane transporter activity, bilirubin transmembrane transporter activity, carboxylic acid transmembrane transporter activity, efflux transmembrane transporter activity, glutathione transmembrane transporter activity, hydrolase activity, long-chain fatty acid transmembrane transporter activity, nucleotide binding, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: apical plasma membrane, basal plasma membrane, basolateral plasma membrane, lateral plasma membrane, membrane, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC-family proteins mediated transport, Arachidonate metabolism, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cobalamin (Cbl, vitamin B12) transport and metabolism, Cytoprotection by HMOX1, Drug ADME, Fatty acid metabolism, Heme degradation, Metabolism, Metabolism of lipids, Metabolism of porphyrins, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, MicroRNAs in cancer - Mus musculus (mouse), Paracetamol ADME, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid signaling pathway - Mus musculus (mouse), Synthesis of Leukotrienes (LT) and Eoxins (EX), Transport of RCbl within the body, Transport of small molecules, Vitamin digestion and absorption - Mus musculus (mouse)
UniProt: O35379
Entrez ID: 17250
|
Does Knockout of Dpp9 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Dpp9
|
cell proliferation
|
Regulatory T cell
|
Gene: Dpp9 (dipeptidylpeptidase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CARD8 inflammasome complex assembly, NLRP1 inflammasome complex assembly, negative regulation of programmed cell death, protein maturation, proteolysis, pyroptotic cell death, pyroptotic inflammatory response; MF: aminopeptidase activity, dipeptidyl-peptidase activity, hydrolase activity, identical protein binding, peptidase activity, serine-type peptidase activity; CC: cell leading edge, cytoplasm, cytosol, microtubule
Pathways:
UniProt: Q8BVG4
Entrez ID: 224897
|
Does Knockout of Krt8 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Krt8
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Krt8 (keratin 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation involved in embryonic placenta development, extrinsic apoptotic signaling pathway, hepatocyte apoptotic process, response to hydrostatic pressure, response to other organism, sarcomere organization, tumor necrosis factor-mediated signaling pathway; MF: protein binding, protein-containing complex binding, scaffold protein binding; CC: Z disc, apicolateral plasma membrane, cell periphery, cell-cell junction, costamere, cytoplasm, dystrophin-associated glycoprotein complex, intermediate filament, intermediate filament cytoskeleton, keratin filament, nuclear matrix, nucleoplasm, nucleus, sarcolemma
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: P11679
Entrez ID: 16691
|
Does Knockout of Krtap1-5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Krtap1-5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Krtap1-5 (keratin associated protein 1-5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q9D6Z9, A2A590
Entrez ID: 69664
|
Does Knockout of Cpsf4l in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Cpsf4l
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cpsf4l (cleavage and polyadenylation specific factor 4-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA 3'-end processing, mRNA processing; MF: RNA binding, metal ion binding, zinc ion binding; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleus
Pathways:
UniProt: G3UWW6, Q9DBA5, Q3TTY7, E9Q2N0, Q91YP9, A2A6P9
Entrez ID: 52670
|
Does Knockout of Ift140 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Ift140
|
response to bacteria
|
macrophage
|
Gene: Ift140 (intraflagellar transport 140)
Type: protein-coding
Summary: Acts upstream of or within several processes, including cilium organization; embryonic organ development; and regionalization. Located in cytoskeleton and photoreceptor cell cilium. Part of intraciliary transport particle A. Is expressed in several structures, including adrenal gland; bone; eye; heart; and perichondrium. Used to study asphyxiating thoracic dystrophy 1 and short-rib thoracic dysplasia 9 with or without polydactyly. Human ortholog(s) of this gene implicated in retinitis pigmentosa and short-rib thoracic dysplasia 9 with or without polydactyly. Orthologous to human IFT140 (intraflagellar transport 140). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell projection organization, cilium assembly, determination of left/right symmetry, embryonic brain development, embryonic camera-type eye development, embryonic cranial skeleton morphogenesis, embryonic digit morphogenesis, heart development, intraciliary retrograde transport, intraciliary transport, limb morphogenesis, neural tube patterning, non-motile cilium assembly, photoreceptor cell outer segment organization, protein localization to cilium, regulation of cilium assembly, regulation of smoothened signaling pathway; CC: axoneme, cell projection, centriole, centrosome, ciliary basal body, cilium, cone photoreceptor outer segment, cytoplasm, cytoskeleton, intraciliary transport particle A, mitochondrion, non-motile cilium, nucleoplasm, photoreceptor connecting cilium
Pathways: Cilium Assembly, Hedgehog 'off' state, Intraflagellar transport, Organelle biogenesis and maintenance, Signal Transduction, Signaling by Hedgehog
UniProt: E9PY46
Entrez ID: 106633
|
Does Knockout of Homer2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Homer2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Homer2 (homer scaffolding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled glutamate receptor signaling pathway, behavioral response to cocaine, calcium-mediated signaling, negative regulation of calcineurin-NFAT signaling cascade, negative regulation of interleukin-2 production, regulation of G protein-coupled receptor signaling pathway, regulation of store-operated calcium entry, regulation of synaptic transmission, glutamatergic, sensory perception of sound; MF: G protein-coupled glutamate receptor binding, actin binding, glutamate receptor binding, identical protein binding, protein binding, protein domain specific binding, protein-containing complex binding, synaptic receptor adaptor activity; CC: apical part of cell, cell projection, cytoplasm, cytosol, dendrite, glutamatergic synapse, intracellular organelle, membrane, neuronal cell body, plasma membrane, postsynaptic density, stereocilium, stereocilium tip, synapse
Pathways: FoxO signaling pathway - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: Q9QWW1
Entrez ID: 26557
|
Does Knockout of Eng in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Eng
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Eng (endoglin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, artery morphogenesis, atrial cardiac muscle tissue morphogenesis, atrioventricular canal morphogenesis, branching involved in blood vessel morphogenesis, cardiac atrium morphogenesis, cardiac jelly development, cardiac ventricle morphogenesis, cell adhesion, cell chemotaxis, cell migration, cell migration involved in endocardial cushion formation, cell motility, central nervous system vasculogenesis, detection of hypoxia, dorsal aorta morphogenesis, endocardial cushion morphogenesis, endocardial cushion to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, extracellular matrix constituent secretion, extracellular matrix disassembly, heart development, heart looping, negative regulation of SMAD protein signal transduction, negative regulation of cell migration, negative regulation of endothelial cell proliferation, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, outflow tract septum morphogenesis, positive regulation of BMP signaling pathway, positive regulation of SMAD protein signal transduction, positive regulation of angiogenesis, positive regulation of collagen biosynthetic process, positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation, positive regulation of gene expression, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of systemic arterial blood pressure, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell differentiation, regulation of DNA-templated transcription, regulation of cardiac muscle cell apoptotic process, regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis, regulation of cell proliferation involved in heart morphogenesis, regulation of transforming growth factor beta receptor signaling pathway, response to hypoxia, smooth muscle tissue development, sprouting angiogenesis, transforming growth factor beta receptor signaling pathway, vascular associated smooth muscle cell development, vasculogenesis, venous blood vessel morphogenesis, ventricular trabecula myocardium morphogenesis, wound healing; MF: BMP binding, coreceptor activity, galactose binding, glycosaminoglycan binding, identical protein binding, protein binding, protein homodimerization activity, signaling receptor activator activity, transforming growth factor beta binding, type I transforming growth factor beta receptor binding, type II transforming growth factor beta receptor binding; CC: cell surface, endothelial microparticle, external side of plasma membrane, extracellular space, membrane, nuclear body, plasma membrane, receptor complex
Pathways:
UniProt: Q63961
Entrez ID: 13805
|
Does Knockout of Glipr2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Glipr2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Glipr2 (GLI pathogenesis-related 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of ERK1 and ERK2 cascade, positive regulation of epithelial cell migration, positive regulation of epithelial to mesenchymal transition, sexual reproduction; MF: protein homodimerization activity; CC: Golgi apparatus, Golgi membrane, extracellular region, extracellular space, membrane
Pathways:
UniProt: Q9CYL5
Entrez ID: 384009
|
Does Knockout of Top3a in Colonic Cancer Cell Line causally result in tumorigenicity?
| 1
| 2,178
|
Knockout
|
Top3a
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Top3a (topoisomerase (DNA) III alpha)
Type: protein-coding
Summary: Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity and single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process and chromosome separation. Predicted to be located in PML body. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA topoisomerase III alpha). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA recombination, DNA repair, DNA topological change, chromosome separation, double-strand break repair via homologous recombination, mitochondrial DNA metabolic process, resolution of DNA recombination intermediates; MF: DNA binding, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, isomerase activity, metal ion binding, single-stranded DNA binding, zinc ion binding; CC: PML body, RecQ family helicase-topoisomerase III complex, chromosome, mitochondrial matrix, mitochondrion, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Transcriptional Regulation by TP53
UniProt: O70157
Entrez ID: 21975
|
Does Knockout of Prpsap1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Prpsap1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Prpsap1 (phosphoribosyl pyrophosphate synthetase-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 5-phosphoribose 1-diphosphate biosynthetic process, nucleotide biosynthetic process, purine nucleotide biosynthetic process; MF: enzyme regulator activity, identical protein binding, kinase binding, magnesium ion binding; CC: cytoplasm, protein-containing complex, ribose phosphate diphosphokinase complex
Pathways: PRPP biosynthesis I
UniProt: Q9D0M1
Entrez ID: 67763
|
Does Knockout of Ddn in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Ddn
|
phagocytosis
|
macrophage
|
Gene: Ddn (dendrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: cell projection, cytoplasm, dendrite, dendritic spine membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, perikaryon, plasma membrane, postsynapse, postsynaptic membrane, presynapse, synapse
Pathways:
UniProt: Q80TS7
Entrez ID: 13199
|
Does Knockout of Ttc8 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Ttc8
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ttc8 (tetratricopeptide repeat domain 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, axon guidance, camera-type eye photoreceptor cell differentiation, cell projection organization, cilium assembly, establishment of anatomical structure orientation, establishment of epithelial cell apical/basal polarity, establishment of planar polarity, fat cell differentiation, inner ear receptor cell stereocilium organization, multi-ciliated epithelial cell differentiation, multicellular organism growth, non-motile cilium assembly, olfactory bulb development, protein localization to plasma membrane, protein transport, regulation of protein localization, regulation of stress fiber assembly, renal tubule development, sensory perception, sensory perception of smell; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding; CC: BBSome, cell projection, centriolar satellite, centriole, centrosome, ciliary basal body, ciliary membrane, cilium, cytoplasm, cytoskeleton, fibrillar center, membrane, non-motile cilium, photoreceptor connecting cilium, plasma membrane
Pathways: BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8VD72
Entrez ID: 76260
|
Does Knockout of Tas2r107 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Tas2r107
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Tas2r107 (taste receptor, type 2, member 107)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity; CC: membrane
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: Q7M725
Entrez ID: 387342
|
Does Knockout of Sp8 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Sp8
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Sp8 (trans-acting transcription factor 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dorsal/ventral pattern formation, embryonic limb morphogenesis, proximal/distal pattern formation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: Q8BMJ8
Entrez ID: 320145
|
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