prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ubfd1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Ubfd1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ubfd1 (ubiquitin family domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q78JW9
Entrez ID: 28018
|
Does Knockout of Lrrn4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Lrrn4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Lrrn4 (leucine rich repeat neuronal 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: long-term memory, visual learning; CC: membrane, plasma membrane
Pathways:
UniProt: P59383
Entrez ID: 320974
|
Does Knockout of Htr2a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Htr2a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Htr2a (5-hydroxytryptamine (serotonin) receptor 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor signaling pathway, artery smooth muscle contraction, behavioral response to cocaine, chemical synaptic transmission, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, intracellular calcium ion homeostasis, memory, negative regulation of potassium ion transport, negative regulation of synaptic transmission, glutamatergic, phospholipase C-activating serotonin receptor signaling pathway, positive regulation of DNA biosynthetic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell population proliferation, positive regulation of cytokine production involved in immune response, positive regulation of cytosolic calcium ion concentration, positive regulation of execution phase of apoptosis, positive regulation of fat cell differentiation, positive regulation of glycolytic process, positive regulation of heat generation, positive regulation of inflammatory response, positive regulation of neuron apoptotic process, positive regulation of phosphatidylinositol biosynthetic process, positive regulation of platelet aggregation, positive regulation of vasoconstriction, presynaptic modulation of chemical synaptic transmission, protein localization to cytoskeleton, regulation of dopamine secretion, release of sequestered calcium ion into cytosol, response to cocaine, response to xenobiotic stimulus, sensitization, sensory perception of temperature stimulus, serotonin receptor signaling pathway, signal transduction, temperature homeostasis, urinary bladder smooth muscle contraction; MF: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, Gq/11-coupled serotonin receptor activity, identical protein binding, neurotransmitter receptor activity, protein tyrosine kinase activator activity, protein-containing complex binding, serotonin binding, serotonin receptor activity; CC: G protein-coupled serotonin receptor complex, axon, caveola, cell body fiber, cell projection, cytoplasmic vesicle, dendrite, dendritic shaft, glutamatergic synapse, membrane, neurofilament, neuronal cell body, plasma membrane, postsynaptic membrane, presynapse, presynaptic membrane, synapse
Pathways: Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Gap junction - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Serotonin receptors, Signal Transduction, Signaling by GPCR
UniProt: P35363
Entrez ID: 15558
|
Does Knockout of Rps15a in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Rps15a
|
phagocytosis
|
macrophage
|
Gene: Rps15a (ribosomal protein S15A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, positive regulation of cell cycle, positive regulation of cell population proliferation, response to virus, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, mitochondrion, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62245
Entrez ID: 267019
|
Does Knockout of Gls in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,272
|
Knockout
|
Gls
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gls (glutaminase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamine catabolic process, chemical synaptic transmission, glutamate biosynthetic process, glutamine metabolic process, intracellular glutamate homeostasis, protein homotetramerization, regulation of respiratory gaseous exchange by nervous system process, suckling behavior; MF: glutaminase activity, hydrolase activity, identical protein binding, protein binding; CC: cytoplasm, cytosol, mitochondrial matrix, mitochondrion, synapse
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), D-Amino acid metabolism - Mus musculus (mouse), GABAergic synapse - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glutamate Neurotransmitter Release Cycle, Glutamate and glutamine metabolism, Glutamatergic synapse - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, MicroRNAs in cancer - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, Proximal tubule bicarbonate reclamation - Mus musculus (mouse), RNA Polymerase II Transcription, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, Transmission across Chemical Synapses, citrulline biosynthesis, glutamine degradation I, glutamine degradation II, superpathway of citrulline metabolism
UniProt: D3Z7P3
Entrez ID: 14660
|
Does Knockout of Phlpp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Phlpp1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, entrainment of circadian clock, intracellular signal transduction, negative regulation of intracellular signal transduction, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of JNK cascade, regulation of MAPK cascade, regulation of T cell anergy, regulation of apoptotic process, regulation of p38MAPK cascade; MF: hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cytoplasm, membrane, nuclear membrane, nucleoplasm, nucleus, plasma membrane
Pathways: Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, PI3K-Akt signaling pathway - Mus musculus (mouse), PIP3 activates AKT signaling, Signal Transduction
UniProt: Q8CHE4
Entrez ID: 98432
|
Does Knockout of Plekhh3 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Plekhh3
|
phagocytosis
|
macrophage
|
Gene: Plekhh3 (pleckstrin homology domain containing, family H (with MyTH4 domain) member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8VCE9
Entrez ID: 217198
|
Does Knockout of Esf1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Esf1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Esf1 (ESF1 nucleolar pre-rRNA processing protein homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q3V1V3
Entrez ID: 66580
|
Does Knockout of Cfap126 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Cfap126
|
response to bacteria
|
renal medulla cell line
|
Gene: Cfap126 (cilia and flagella associated protein 126)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium organization, flagellated sperm motility; CC: apical plasma membrane, axonemal B tubule inner sheath, axonemal microtubule, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, membrane, motile cilium, plasma membrane, sperm flagellum
Pathways:
UniProt: Q6P8X9
Entrez ID: 75472
|
Does Knockout of Tmem161b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Tmem161b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmem161b (transmembrane protein 161B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of cardiac muscle cell action potential, regulation of heart rate; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q8C2L6
Entrez ID: 72745
|
Does Knockout of Tctn3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Tctn3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tctn3 (tectonic family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cell projection organization, cilium assembly, positive regulation of apoptotic process, smoothened signaling pathway; CC: membrane, nucleus
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8R2Q6
Entrez ID: 67590
|
Does Knockout of Amigo2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Amigo2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Amigo2 (adhesion molecule with Ig like domain 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of neuron apoptotic process, negative regulation of programmed cell death, positive regulation of synapse assembly; CC: membrane, nucleus, plasma membrane
Pathways: RAC1 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80ZD9
Entrez ID: 105827
|
Does Knockout of Prss41 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Prss41
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Prss41 (serine protease 41)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: intracellular organelle, membrane, plasma membrane, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q920S2
Entrez ID: 71003
|
Does Knockout of Fkbp1b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Fkbp1b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fkbp1b (FK506 binding protein 1b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell proliferation, calcium-mediated signaling, establishment of localization in cell, insulin secretion, negative regulation of calcium-mediated signaling, negative regulation of heart rate, negative regulation of insulin secretion involved in cellular response to glucose stimulus, negative regulation of release of sequestered calcium ion into cytosol, neuronal action potential propagation, positive regulation of axon regeneration, positive regulation of cytosolic calcium ion concentration, positive regulation of sequestering of calcium ion, protein folding, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of heart rate, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of ryanodine-sensitive calcium-release channel activity, release of sequestered calcium ion into cytosol, response to glucose, response to redox state, smooth muscle contraction; MF: FK506 binding, calcium channel inhibitor activity, calcium channel regulator activity, cyclic nucleotide binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity, protein binding, signaling receptor binding, transmembrane transporter binding; CC: Z disc, calcium channel complex, cytoplasm, membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways: Cardiac conduction, Ion channel transport, Ion homeostasis, Muscle contraction, Stimuli-sensing channels, Transport of small molecules
UniProt: Q9Z2I2
Entrez ID: 14226
|
Does Knockout of Rbm12b2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Rbm12b2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rbm12b2 (RNA binding motif protein 12 B2)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human RBM12B (RNA binding motif protein 12B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: nucleoplasm, ribonucleoprotein complex
Pathways:
UniProt: Q66JV4
Entrez ID: 77604
|
Does Knockout of Knl1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Knl1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Knl1 (kinetochore scaffold 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, establishment of localization in cell, head development, homologous chromosome orientation in meiotic metaphase I, mitotic sister chromatid segregation, phagocytosis, positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of meiosis I spindle assembly checkpoint, protein localization to kinetochore, regulation of mitotic cell cycle spindle assembly checkpoint; MF: microtubule binding, molecular_function; CC: Knl1/Spc105 complex, acrosomal vesicle, chromosome, chromosome, centromeric region, cytoplasm, kinetochore, nuclear body, nucleoplasm, nucleus, outer kinetochore
Pathways:
UniProt: Q66JQ7
Entrez ID: 76464
|
Does Knockout of Krt19 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Krt19
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Krt19 (keratin 19)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: Notch signaling pathway, cell differentiation involved in embryonic placenta development, epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium, response to estrogen, sarcomere organization; MF: protein binding, protein-containing complex binding, structural constituent of muscle, structural constituent of skin epidermis, structural molecule activity; CC: Z disc, apicolateral plasma membrane, cell periphery, costamere, cytoskeleton, dystrophin-associated glycoprotein complex, intermediate filament, keratin filament, plasma membrane, sarcolemma, terminal web
Pathways: Developmental Biology, Estrogen signaling pathway - Mus musculus (mouse), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: P19001
Entrez ID: 16669
|
Does Knockout of Pdilt in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Pdilt
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pdilt (protein disulfide isomerase-like, testis expressed)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, germ cell migration, protein folding, spermatid development, spermatogenesis; MF: isomerase activity, protein binding, protein disulfide isomerase activity, protein folding chaperone; CC: endoplasmic reticulum
Pathways:
UniProt: Q9DAN1
Entrez ID: 71830
|
Does Knockout of Speer3 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Speer3
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Speer3 (spermatogenesis associated glutamate (E)-rich protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D4A3, W4VSP1
Entrez ID: 71026
|
Does Knockout of Gtpbp6 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Gtpbp6
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gtpbp6 (GTP binding protein 6 (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, metal ion binding, molecular_function, nucleotide binding, ribosome binding
Pathways:
UniProt: Q3U6U5
Entrez ID: 107999
|
Does Knockout of Hnrnpab in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Hnrnpab
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Hnrnpab (heterogeneous nuclear ribonucleoprotein A/B)
Type: protein-coding
Summary: This gene encodes a protein with consensus RNA binding domains present in a number of other RNA binding proteins and a glycine-rich C-terminus. This gene overlaps in a tail-to-tail orientation the gene encoding alanine-glyoxylate aminotransferase 2-like 2. Some of the exons of this gene are interspersed with exons of alanine-glyoxylate aminotransferase 2-like 2. Two alternatively spliced transcript variants that encode distinct proteins have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromosomal 5-methylcytosine DNA demethylation pathway, epithelial to mesenchymal transition, mRNA modification, negative regulation of RNA metabolic process, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of macromolecule biosynthetic process, regulation of cellular localization, regulation of gene expression, regulation of intracellular mRNA localization; MF: DNA binding, RNA binding, nucleic acid binding, protein binding, protein-containing complex binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, dendrite, glutamatergic synapse, mRNA editing complex, neuronal ribonucleoprotein granule, nucleoplasm, nucleus, postsynapse, presynaptic cytosol, protein-containing complex, ribonucleoprotein complex
Pathways:
UniProt: Q99020
Entrez ID: 15384
|
Does Knockout of Serpina3a in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Serpina3a
|
phagocytosis
|
macrophage
|
Gene: Serpina3a (serine (or cysteine) peptidase inhibitor, clade A, member 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q6P4P1
Entrez ID: 74069
|
Does Knockout of Gm4894 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Gm4894
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm4894 (predicted gene 4894)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 235327
|
Does Knockout of Atp11b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Atp11b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Atp11b (ATPase, class VI, type 11B)
Type: protein-coding
Summary: Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to be located in early endosome membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum; plasma membrane; and recycling endosome. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and dentate gyrus subgranular zone. Orthologous to human ATP11B (ATPase phospholipid transporting 11B (putative)). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lipid transport, phospholipid translocation, phospholipid transport; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, magnesium ion binding, metal ion binding, nucleotide binding; CC: Golgi apparatus, early endosome, early endosome membrane, endoplasmic reticulum, endosome, membrane, phospholipid-translocating ATPase complex, plasma membrane, recycling endosome, recycling endosome membrane
Pathways: Immune System, Innate Immune System, Ion channel transport, Ion transport by P-type ATPases, Neutrophil degranulation, Transport of small molecules
UniProt: Q6DFW5
Entrez ID: 76295
|
Does Knockout of Mpv17l in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Mpv17l
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mpv17l (Mpv17 transgene, kidney disease mutant-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of hydrogen peroxide biosynthetic process, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, reactive oxygen species metabolic process; CC: cytoplasm, membrane, mitochondrion, peroxisomal membrane, peroxisome
Pathways: Peroxisome - Mus musculus (mouse)
UniProt: Q99MS3
Entrez ID: 93734
|
Does Knockout of Lct in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Lct
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Lct (lactase)
Type: protein-coding
Summary: Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds; protein homodimerization activity; and transferase activity. Predicted to be involved in several processes, including disaccharide catabolic process; glycosylceramide catabolic process; and quercetin catabolic process. Predicted to be located in brush border and external side of apical plasma membrane. Human ortholog(s) of this gene implicated in congenital lactase deficiency. Orthologous to human LCT (lactase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: carbohydrate metabolic process, cellobiose catabolic process, glycosylceramide catabolic process, lactose catabolic process, quercetin catabolic process, response to ethanol, response to hypoxia, response to iron(II) ion, response to lead ion, response to nickel cation, response to nutrient, response to xenobiotic stimulus; MF: beta-glucosidase activity, catalytic activity, galactosylceramidase activity, glucosylceramidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, lactase activity, phlorizin hydrolase activity, protein homodimerization activity, transferase activity; CC: apical plasma membrane, brush border, external side of apical plasma membrane, membrane, plasma membrane
Pathways: Carbohydrate digestion and absorption - Mus musculus (mouse), Digestion, Digestion and absorption, Digestion of dietary carbohydrate, Galactose metabolism - Mus musculus (mouse), lactose degradation III
UniProt: F8VPT3
Entrez ID: 226413
|
Does Knockout of Vmn1r158 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Vmn1r158
|
response to virus
|
Microglial Cell Line
|
Gene: Vmn1r158 (vomeronasal 1 receptor 158)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: G3UY92
Entrez ID: 100043067
|
Does Knockout of Krt18 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Krt18
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Krt18 (keratin 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, extrinsic apoptotic signaling pathway, hepatocyte apoptotic process, intermediate filament cytoskeleton organization, negative regulation of apoptotic process, tumor necrosis factor-mediated signaling pathway; MF: protein binding, scaffold protein binding, structural molecule activity; CC: cell periphery, centriolar satellite, cytoplasm, cytoskeleton, cytosol, external side of plasma membrane, extracellular space, intermediate filament, keratin filament, microtubule organizing center, nuclear matrix, nucleolus, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: Developmental Biology, Estrogen signaling pathway - Mus musculus (mouse), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: P05784
Entrez ID: 16668
|
Does Knockout of Grem1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Grem1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Grem1 (gremlin 1, DAN family BMP antagonist)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, animal organ morphogenesis, cardiac muscle cell differentiation, cardiac muscle cell myoblast differentiation, cell migration involved in sprouting angiogenesis, cell morphogenesis, cell-cell signaling, collagen fibril organization, determination of dorsal identity, embryonic limb morphogenesis, endothelial cell migration, limb development, mesenchymal to epithelial transition involved in metanephros morphogenesis, negative regulation of BMP signaling pathway, negative regulation of DNA-templated transcription, negative regulation of SMAD protein signal transduction, negative regulation of apoptotic process, negative regulation of bone mineralization, negative regulation of bone mineralization involved in bone maturation, negative regulation of bone remodeling, negative regulation of bone trabecula formation, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of chondrocyte differentiation, negative regulation of leukocyte chemotaxis, negative regulation of monocyte chemotaxis, negative regulation of osteoblast differentiation, negative regulation of osteoblast proliferation, negative regulation of osteoclast proliferation, positive regulation of DNA-templated transcription, positive regulation of angiogenesis, positive regulation of branching involved in ureteric bud morphogenesis, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cell population proliferation, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of receptor internalization, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial growth factor signaling pathway, proximal/distal pattern formation, regulation of epithelial to mesenchymal transition, regulation of focal adhesion assembly, regulation of signal transduction, regulation of stress-activated MAPK cascade, sequestering of BMP from receptor via BMP binding, signal transduction, signal transduction by p53 class mediator, ureteric bud formation; MF: BMP binding, cytokine activity, heparan sulfate proteoglycan binding, protein homodimerization activity, receptor ligand activity, transmembrane receptor protein tyrosine kinase activator activity, vascular endothelial growth factor receptor 2 binding; CC: cell surface, extracellular region, extracellular space
Pathways: TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: O70326
Entrez ID: 23892
|
Does Knockout of Mcm3ap in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,412
|
Knockout
|
Mcm3ap
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Mcm3ap (minichromosome maintenance complex component 3 associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, mRNA export from nucleus, mRNA transport, nucleosome organization, poly(A)+ mRNA export from nucleus, protein transport, somatic hypermutation of immunoglobulin genes; MF: acyltransferase activity, chromatin binding, histone H3 acetyltransferase activity, histone acetyltransferase activity, histone binding, nucleic acid binding, transferase activity; CC: chromosome, cytoplasm, cytosol, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore nuclear basket, nucleoplasm, nucleus, transcription export complex 2
Pathways:
UniProt: Q9WUU9
Entrez ID: 54387
|
Does Knockout of Ikbip in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Ikbip
|
response to bacteria
|
macrophage
|
Gene: Ikbip (IKBKB interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: response to interleukin-1, response to lipopolysaccharide, response to tumor necrosis factor; MF: molecular_function, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus
Pathways:
UniProt: Q9DBZ1
Entrez ID: 67454
|
Does Knockout of Zfp30 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Zfp30
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Zfp30 (zinc finger protein 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q60585
Entrez ID: 22693
|
Does Knockout of Htr7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Htr7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Htr7 (5-hydroxytryptamine (serotonin) receptor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor signaling pathway, adenylate cyclase-activating serotonin receptor signaling pathway, behavioral response to pain, chemical synaptic transmission, circadian rhythm, detection of mechanical stimulus involved in sensory perception of pain, dopaminergic neuron differentiation, long-term synaptic potentiation, memory, negative regulation of serotonin secretion, positive regulation of neuron projection development, presynaptic modulation of chemical synaptic transmission, regulation of vein smooth muscle contraction, response to corticosterone, serotonin receptor signaling pathway, signal transduction, smooth muscle contraction, urinary bladder smooth muscle contraction, vasoconstriction; MF: G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, neurotransmitter receptor activity, serotonin receptor activity; CC: axon terminus, cilium, dendrite, membrane, neuronal cell body, nucleoplasm, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse, synaptic vesicle
Pathways: Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), RHOBTB3 ATPase cycle, Ras signaling pathway - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Serotonin receptors, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P32304
Entrez ID: 15566
|
Does Knockout of Spata21 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Spata21
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Spata21 (spermatogenesis associated 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, metal ion binding, molecular_function
Pathways:
UniProt: Q8BHW6
Entrez ID: 329972
|
Does Knockout of Ncr1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Ncr1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ncr1 (natural cytotoxicity triggering receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, detection of virus, immune response-regulating signaling pathway; CC: cell surface, membrane, plasma membrane
Pathways: Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: Q8C567
Entrez ID: 17086
|
Does Knockout of Mrpl30 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Mrpl30
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mrpl30 (mitochondrial ribosomal protein L30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: molecular_function, structural constituent of ribosome; CC: large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D7N6
Entrez ID: 107734
|
Does Knockout of Dctn3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Dctn3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dctn3 (dynactin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cytoskeleton-dependent cytokinesis, microtubule-based process; CC: centrosome, chromosome, chromosome, centromeric region, cleavage furrow, cytoplasm, cytoskeleton, cytosol, dynactin complex, kinetochore, microtubule, microtubule associated complex, midbody, nucleolus, perinuclear region of cytoplasm, spindle
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Mus musculus (mouse), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Salmonella infection - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Z0Y1
Entrez ID: 53598
|
Does Knockout of Kyat3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Kyat3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kyat3 (kynurenine aminotransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate metabolic process, L-kynurenine catabolic process, amino acid metabolic process, kynurenine metabolic process; MF: cysteine-S-conjugate beta-lyase activity, kynurenine-glyoxylate transaminase activity, kynurenine-oxoglutarate transaminase activity, lyase activity, protein homodimerization activity, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytoplasm, mitochondrion
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Selenocompound metabolism - Mus musculus (mouse), Tryptophan metabolism - Mus musculus (mouse)
UniProt: Q71RI9
Entrez ID: 229905
|
Does Knockout of Idh3b in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Idh3b
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Idh3b (isocitrate dehydrogenase 3 (NAD+) beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: isocitrate metabolic process, tricarboxylic acid cycle; MF: NAD binding, magnesium ion binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein-macromolecule adaptor activity; CC: isocitrate dehydrogenase complex (NAD+), mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Metabolism, TCA cycle variation III (eukaryotic)
UniProt: A0A668KL51, Q91VA7, V9GXV0
Entrez ID: 170718
|
Does Knockout of Sparc in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Sparc
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Sparc (secreted acidic cysteine rich glycoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone development, cellular response to growth factor stimulus, lung development, negative regulation of angiogenesis, negative regulation of endothelial cell proliferation, pigmentation, positive regulation of endothelial cell migration, regulation of cell morphogenesis, regulation of cell population proliferation, regulation of synapse organization, semicircular canal morphogenesis; MF: calcium ion binding, collagen binding, extracellular matrix binding, extracellular matrix structural constituent, metal ion binding, protein binding; CC: basement membrane, cell surface, cytoplasm, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, nuclear matrix, platelet alpha granule, platelet alpha granule membrane, synapse, vesicle
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, ECM proteoglycans, Extracellular matrix organization, Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Scavenging by Class H Receptors, Vesicle-mediated transport
UniProt: P07214
Entrez ID: 20692
|
Does Knockout of Tmco4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Tmco4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmco4 (transmembrane and coiled-coil domains 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q91WU4
Entrez ID: 77056
|
Does Knockout of Mrm1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Mrm1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mrm1 (mitochondrial rRNA methyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, methylation, rRNA 2'-O-methylation, rRNA methylation, rRNA modification, rRNA processing; MF: RNA binding, RNA methyltransferase activity, methyltransferase activity, rRNA (guanine) methyltransferase activity, rRNA (guanosine-2'-O-)-methyltransferase activity, transferase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q99J25
Entrez ID: 217038
|
Does Knockout of Ccdc13 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Ccdc13
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ccdc13 (coiled-coil domain containing 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, axoneme assembly, cell projection organization, cytoplasmic microtubule organization, non-motile cilium assembly; MF: microtubule binding, molecular_function; CC: axonemal central pair, cell projection, centriolar satellite, centrosome, cytoplasm, cytoskeleton
Pathways:
UniProt: D3YV10
Entrez ID: 100502861
|
Does Knockout of Btbd16 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Btbd16
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Btbd16 (BTB domain containing 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q173
Entrez ID: 330660
|
Does Knockout of Zswim3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Zswim3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zswim3 (zinc finger SWIM-type containing 3)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Orthologous to human ZSWIM3 (zinc finger SWIM-type containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q8CFL8
Entrez ID: 67538
|
Does Knockout of Il27ra in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Il27ra
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Il27ra (interleukin 27 receptor, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, defense response to Gram-positive bacterium, interleukin-27-mediated signaling pathway, negative regulation of T cell extravasation, negative regulation of T-helper 17 type immune response, negative regulation of cellular extravasation, negative regulation of interleukin-17 production, negative regulation of interleukin-6 production, negative regulation of neuron apoptotic process, negative regulation of tumor necrosis factor production, negative regulation of type 2 immune response, positive regulation of T-helper 1 type immune response, positive regulation of type II interferon production, regulation of isotype switching to IgG isotypes; MF: interleukin-27 receptor activity, protein binding, transmembrane signaling receptor activity; CC: cytoplasm, extracellular region, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-12 family signaling, Interleukin-27 signaling, Interleukin-35 Signalling, JAK-STAT signaling pathway - Mus musculus (mouse), Signaling by Interleukins, Th17 cell differentiation - Mus musculus (mouse)
UniProt: O70394
Entrez ID: 50931
|
Does Knockout of H2-Aa in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
H2-Aa
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: H2-Aa (histocompatibility 2, class II antigen A, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of peptide antigen, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response, immune system process, negative regulation of T cell proliferation, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of T cell differentiation, positive regulation of immune response; MF: MHC class II protein complex binding, peptide antigen binding, protein binding, protein-containing complex binding; CC: MHC class II protein complex, external side of plasma membrane, late endosome membrane, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: Allograft rejection - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Intestinal immune network for IgA production - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: P14434
Entrez ID: 14960
|
Does Knockout of Uqcc1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Uqcc1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Uqcc1 (ubiquinol-cytochrome c reductase complex assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex III assembly; CC: cytoplasmic vesicle, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CWU6
Entrez ID: 56046
|
Does Knockout of Il13ra2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Il13ra2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Il13ra2 (interleukin 13 receptor, alpha 2)
Type: protein-coding
Summary: This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cytokine-mediated signaling pathway, immunoglobulin mediated immune response, interleukin-13-mediated signaling pathway, negative regulation of immunoglobulin production, negative regulation of mast cell degranulation, positive regulation of cell population proliferation, transforming growth factor beta receptor signaling pathway, transforming growth factor beta1 production; MF: cytokine binding, cytokine receptor activity, protein binding; CC: external side of plasma membrane, extracellular region, extracellular space, membrane, plasma membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-4 and Interleukin-13 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Signaling by Interleukins
UniProt: O88786
Entrez ID: 16165
|
Does Knockout of Crlf2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Crlf2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Crlf2 (cytokine receptor-like factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, inflammatory response, positive regulation of cell population proliferation, positive regulation of interleukin-5 production, positive regulation of mast cell activation, positive regulation of receptor signaling pathway via STAT; MF: coreceptor activity, cytokine activity, cytokine receptor activity, protein binding; CC: external side of plasma membrane, extracellular region, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse)
UniProt: Q8CII9
Entrez ID: 57914
|
Does Knockout of Spata19 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Spata19
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Spata19 (spermatogenesis associated 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, sperm mitochondrion organization, spermatogenesis; CC: cell projection, cilium, membrane, mitochondrial outer membrane, mitochondrion, motile cilium, sperm flagellum, sperm midpiece
Pathways:
UniProt: Q9DAQ9
Entrez ID: 75469
|
Does Knockout of Phf10 in Lung Cancer Cell Line causally result in tumorigenicity?
| 1
| 1,781
|
Knockout
|
Phf10
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Phf10 (PHD finger protein 10)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity; histone acetyltransferase activity; and transcription coregulator activity. Involved in nervous system development. Part of npBAF complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and tooth. Orthologous to human PHF10 (PHD finger protein 10). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromatin remodeling, nervous system development, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: chromatin binding, histone acetyltransferase activity, metal ion binding, protein binding, transcription coregulator activity, zinc ion binding; CC: RSC-type complex, SWI/SNF complex, chromatin, kinetochore, npBAF complex, nuclear matrix, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Hepatocellular carcinoma - Mus musculus (mouse), SWI/SNF chromatin remodelers
UniProt: Q9D8M7
Entrez ID: 72057
|
Does Knockout of Gadl1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Gadl1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gadl1 (glutamate decarboxylase-like 1)
Type: protein-coding
Summary: Predicted to enable carboxy-lyase activity. Predicted to be involved in carboxylic acid metabolic process. Predicted to be active in cytoplasm. Orthologous to human GADL1 (glutamate decarboxylase like 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, carboxylic acid metabolic process; MF: aspartate 1-decarboxylase activity, carbon-carbon lyase activity, carboxy-lyase activity, lyase activity, molecular_function, pyridoxal phosphate binding, sulfinoalanine decarboxylase activity
Pathways: Aspartate and asparagine metabolism, Degradation of cysteine and homocysteine, Metabolism, Metabolism of amino acids and derivatives, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Sulfur amino acid metabolism, Taurine and hypotaurine metabolism - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse)
UniProt: Q80WP8
Entrez ID: 73748
|
Does Knockout of Mtpap in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Mtpap
|
response to virus
|
Microglial Cell Line
|
Gene: Mtpap (mitochondrial poly(A) polymerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, RNA metabolic process, histone mRNA catabolic process, mRNA processing, mitochondrial RNA 3'-end processing, mitochondrial mRNA polyadenylation; MF: ATP binding, RNA binding, UTP binding, identical protein binding, magnesium ion binding, manganese ion binding, metal ion binding, nucleotide binding, poly(A) RNA polymerase activity, protein homodimerization activity, transferase activity; CC: cytoplasm, mitochondrion, nucleoplasm
Pathways:
UniProt: Q9D0D3
Entrez ID: 67440
|
Does Knockout of Prpf6 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,663
|
Knockout
|
Prpf6
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Prpf6 (pre-mRNA splicing factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA localization, RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, positive regulation of transcription by RNA polymerase II, spliceosomal tri-snRNP complex assembly; MF: RNA binding, identical protein binding, nuclear androgen receptor binding, protein-macromolecule adaptor activity, ribonucleoprotein complex binding, transcription coactivator activity; CC: U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, centrosome, ciliary basal body, cytosol, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q91YR7
Entrez ID: 68879
|
Does Knockout of Bok in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Bok
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bok (BCL2-related ovarian killer)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular component disassembly involved in execution phase of apoptosis, extrinsic apoptotic signaling pathway in absence of ligand, intrinsic apoptotic signaling pathway by p53 class mediator, intrinsic apoptotic signaling pathway in response to DNA damage, male gonad development, negative regulation of mitochondrial depolarization, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, negative regulation of necroptotic process, negative regulation of neuron apoptotic process, neuron apoptotic process, oligodendrocyte differentiation, positive regulation of PERK-mediated unfolded protein response, positive regulation of apoptotic process, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of execution phase of apoptosis, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, protein complex oligomerization, regulation of apoptotic process, regulation of autophagy, regulation of chorionic trophoblast cell proliferation, regulation of cytosolic calcium ion concentration, regulation of granulosa cell apoptotic process, release of cytochrome c from mitochondria, response to cisplatin, transmembrane transport; MF: BH domain binding, channel activity, protein binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, protein-containing complex binding, signaling receptor binding, ubiquitin protein ligase binding; CC: Golgi apparatus, cis-Golgi network membrane, cytoplasm, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, nuclear outer membrane, nucleus, recycling endosome membrane, trans-Golgi network membrane
Pathways: Apoptosis - multiple species - Mus musculus (mouse)
UniProt: O35425
Entrez ID: 51800
|
Does Knockout of Fnta in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Fnta
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fnta (farnesyltransferase, CAAX box, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: enzyme-linked receptor protein signaling pathway, negative regulation of apoptotic process, nuclear envelope organization, peptide pheromone maturation, positive regulation of Rac protein signal transduction, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of skeletal muscle acetylcholine-gated channel clustering, protein farnesylation, protein geranylgeranylation, protein maturation, regulation of microtubule-based movement; MF: CAAX-protein geranylgeranyltransferase activity, Rab geranylgeranyltransferase activity, acetyltransferase activator activity, alpha-tubulin binding, enzyme binding, heterocyclic compound binding, microtubule binding, molecular adaptor activity, peptide binding, prenyltransferase activity, protein farnesyltransferase activity, protein geranylgeranyltransferase activity, protein prenyltransferase activity, receptor tyrosine kinase binding, small molecule binding, transferase activity, zinc ion binding; CC: CAAX-protein geranylgeranyltransferase complex, cytoplasm, microtubule associated complex, protein farnesyltransferase complex
Pathways: Terpenoid backbone biosynthesis - Mus musculus (mouse)
UniProt: Q61239
Entrez ID: 14272
|
Does Knockout of Lrrc10 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Lrrc10
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Lrrc10 (leucine rich repeat containing 10)
Type: protein-coding
Summary: Enables actin binding activity and alpha-actinin binding activity. Acts upstream of or within cardiac muscle cell development. Located in several cellular components, including cytoskeleton; mitochondrion; and sarcomere. Is expressed in heart and male reproductive gland or organ. Used to study dilated cardiomyopathy. Orthologous to human LRRC10 (leucine rich repeat containing 10). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cardiac muscle cell development; MF: actin binding, alpha-actinin binding; CC: cytoskeleton, mitochondrion, myofibril, nucleus, sarcomere
Pathways:
UniProt: Q8K3W2
Entrez ID: 237560
|
Does Knockout of Psg26 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Psg26
|
response to virus
|
Microglial Cell Line
|
Gene: Psg26 (pregnancy-specific beta-1-glycoprotein 26)
Type: protein-coding
Summary: Predicted to be involved in T cell activation and immune response. Predicted to be located in apical plasma membrane and cytosol. Predicted to be active in external side of plasma membrane. Orthologous to human CEACAM21 (CEA cell adhesion molecule 21). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: T cell activation, female pregnancy, immune response; CC: cellular_component, external side of plasma membrane
Pathways:
UniProt: Q4KL65
Entrez ID: 574429
|
Does Knockout of Amn1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Amn1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Amn1 (antagonist of mitotic exit network 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cobalamin transport, vesicle-mediated transport; MF: cargo receptor activity, molecular_function; CC: SCF ubiquitin ligase complex, microvillus membrane
Pathways:
UniProt: B8JKV0
Entrez ID: 232566
|
Does Knockout of Dnm1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Dnm1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Dnm1 (dynamin 1)
Type: protein-coding
Summary: This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: G protein-coupled receptor internalization, clathrin coat assembly involved in endocytosis, endocytosis, endosome organization, modulation of chemical synaptic transmission, positive regulation of synaptic vesicle endocytosis, positive regulation of synaptic vesicle recycling, protein homooligomerization, protein homotetramerization, receptor internalization, receptor-mediated endocytosis, regulation of synaptic vesicle endocytosis, regulation of vesicle size, synaptic vesicle budding from presynaptic endocytic zone membrane, synaptic vesicle endocytosis, vesicle scission; MF: D2 dopamine receptor binding, GDP binding, GTP binding, GTPase activity, SH3 domain binding, hydrolase activity, identical protein binding, microtubule binding, nitric-oxide synthase binding, nucleotide binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein homodimerization activity, protein kinase binding, protein serine/threonine kinase binding, protein-containing complex binding; CC: Golgi apparatus, cell projection, chromaffin granule, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, endocytic vesicle, glutamatergic synapse, membrane, membrane coat, microtubule, myelin sheath, photoreceptor inner segment, photoreceptor ribbon synapse, plasma membrane, presynapse, presynaptic endocytic zone membrane, protein-containing complex, synapse, synaptic vesicle, varicosity
Pathways: Adaptive Immune System, Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Immune System, Innate Immune System, L1CAM interactions, MHC class II antigen presentation, Membrane Trafficking, Nervous system development, Phospholipase D signaling pathway - Mus musculus (mouse), Recycling pathway of L1, Synaptic vesicle cycle - Mus musculus (mouse), Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Vesicle-mediated transport
UniProt: P39053
Entrez ID: 13429
|
Does Knockout of Fastkd3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Fastkd3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fastkd3 (FAST kinase domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial RNA processing, mitochondrial cytochrome c oxidase assembly, positive regulation of mitochondrial translation, regulation of mitochondrial mRNA stability; CC: mitochondrial matrix, mitochondrion, nucleoplasm, ribonucleoprotein granule
Pathways:
UniProt: Q8BSN9
Entrez ID: 69577
|
Does Knockout of Pde7a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Pde7a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pde7a (phosphodiesterase 7A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cAMP catabolic process, negative regulation of cAMP/PKA signal transduction, signal transduction; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cyclic-nucleotide phosphodiesterase activity, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity; CC: cytoplasm, cytosol
Pathways: G alpha (s) signalling events, GPCR downstream signalling, Morphine addiction - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P70453
Entrez ID: 18583
|
Does Knockout of Ccdc90b in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Ccdc90b
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Ccdc90b (coiled-coil domain containing 90B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q8C3X2
Entrez ID: 66365
|
Does Knockout of Mlf1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Mlf1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mlf1 (myeloid leukemia factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, cell differentiation, myeloid progenitor cell differentiation, regulation of DNA-templated transcription, regulation of cell cycle G1/S phase transition, regulation of signal transduction by p53 class mediator; MF: DNA binding, protein binding, protein domain specific binding; CC: cell projection, ciliary basal body, ciliary base, cilium, cytoplasm, cytoskeleton, motile cilium, non-motile cilium, nucleus, perinuclear region of cytoplasm
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q9QWV4
Entrez ID: 17349
|
Does Knockout of Pfkfb1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Pfkfb1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pfkfb1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate phosphorylation, fructose 2,6-bisphosphate metabolic process, fructose metabolic process, gluconeogenesis, glycolytic process, negative regulation of glycolytic process through fructose-6-phosphate, positive regulation of gluconeogenesis, positive regulation of glycolytic process through fructose-6-phosphate; MF: 6-phosphofructo-2-kinase activity, ATP binding, catalytic activity, fructose-2,6-bisphosphate 2-phosphatase activity, fructose-6-phosphate binding, hydrolase activity, identical protein binding, kinase activity, kinase binding, nucleotide binding, transferase activity; CC: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex, cytosol
Pathways: AMPK signaling pathway - Mus musculus (mouse), Fructose and mannose metabolism - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glucose metabolism, Glycolysis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
UniProt: P70266
Entrez ID: 18639
|
Does Knockout of Cwc22 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Cwc22
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cwc22 (CWC22 spliceosome-associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding; CC: U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, catalytic step 2 spliceosome, cytosol, nuclear speck, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8C5N3
Entrez ID: 80744
|
Does Knockout of Cebpe in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Cebpe
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cebpe (CCAAT/enhancer binding protein epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, cellular response to lipopolysaccharide, granulocyte differentiation, macrophage differentiation, myeloid cell differentiation, phagocytosis, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein-containing complex binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, nucleoplasm, nucleus, plasma membrane
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q6PZD9
Entrez ID: 110794
|
Does Knockout of Gpr143 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Gpr143
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gpr143 (G protein-coupled receptor 143)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, melanosome localization, melanosome organization, melanosome transport, neuropeptide signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, regulation of melanosome organization, regulation of melanosome transport, signal transduction; MF: G protein-coupled receptor activity, L-DOPA binding, L-DOPA receptor activity, L-tyrosine binding, dopamine binding; CC: Golgi apparatus, apical plasma membrane, cell junction, lysosomal membrane, lysosome, melanosome, melanosome membrane, membrane, nuclear body, nucleoplasm, plasma membrane
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Signal Transduction, Signaling by GPCR
UniProt: P70259
Entrez ID: 18241
|
Does Knockout of Nell1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Nell1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nell1 (NEL-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of osteoblast proliferation, negative regulation of protein catabolic process, positive regulation of apoptotic process, positive regulation of bone mineralization, positive regulation of ossification, positive regulation of osteoblast differentiation, regulation of gene expression, regulation of osteoblast differentiation; MF: calcium ion binding, heparin binding, identical protein binding, metal ion binding, protein kinase C binding; CC: cytoplasm, extracellular region, extracellular space, nuclear envelope, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q2VWQ2
Entrez ID: 338352
|
Does Knockout of Arhgef39 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Arhgef39
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Arhgef39 (Rho guanine nucleotide exchange factor 39)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell migration; CC: membrane, plasma membrane
Pathways: Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, RAC1 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling
UniProt: Q66JY6
Entrez ID: 230098
|
Does Knockout of Tulp2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Tulp2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Tulp2 (TUB like protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein localization to cilium; MF: phosphoric diester hydrolase activity, protein-containing complex binding; CC: cilium, cytoplasm, extracellular region
Pathways:
UniProt: P46686
Entrez ID: 56734
|
Does Knockout of Cmss1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Cmss1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cmss1 (cms small ribosomal subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9CZT6
Entrez ID: 66497
|
Does Knockout of Zfp386 in cardiac muscle cell line causally result in protein/peptide accumulation?
| 0
| 1,662
|
Knockout
|
Zfp386
|
protein/peptide accumulation
|
cardiac muscle cell line
|
Gene: Zfp386 (zinc finger protein 386 (Kruppel-like))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, double-stranded DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q1WWJ5, Q3TN43
Entrez ID: 56220
|
Does Knockout of Itga2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Itga2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Itga2 (integrin alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell adhesion mediated by integrin, cell-cell adhesion, cell-matrix adhesion, cell-substrate adhesion, cellular response to estradiol stimulus, cellular response to mechanical stimulus, collagen-activated signaling pathway, detection of mechanical stimulus involved in sensory perception of pain, female pregnancy, focal adhesion assembly, hepatocyte differentiation, hypotonic response, integrin-mediated signaling pathway, mammary gland development, mesodermal cell differentiation, positive regulation of cell adhesion, positive regulation of cell projection organization, positive regulation of collagen biosynthetic process, positive regulation of epithelial cell migration, positive regulation of leukocyte migration, positive regulation of phagocytosis, engulfment, positive regulation of positive chemotaxis, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of smooth muscle contraction, positive regulation of translation, positive regulation of transmission of nerve impulse, response to L-ascorbic acid, response to amine, response to hypoxia, response to muscle activity, response to parathyroid hormone, response to xenobiotic stimulus, skin morphogenesis, substrate-dependent cell migration; MF: amyloid-beta binding, collagen binding, collagen binding involved in cell-matrix adhesion, collagen receptor activity, integrin binding, laminin binding, metal ion binding, protein-containing complex binding, signaling receptor activity; CC: axon, axon terminus, basal part of cell, cell projection, cell surface, external side of plasma membrane, focal adhesion, integrin alpha2-beta1 complex, integrin complex, membrane, perinuclear region of cytoplasm, plasma membrane, presynapse
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Integrin cell surface interactions, MET activates PTK2 signaling, MET promotes cell motility, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Small cell lung cancer - Mus musculus (mouse), Syndecan interactions
UniProt: Q62469
Entrez ID: 16398
|
Does Knockout of Gpc5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Gpc5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gpc5 (glypican 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, positive regulation of canonical Wnt signaling pathway, regulation of protein localization to membrane, regulation of signal transduction; CC: Golgi lumen, cell surface, extracellular region, membrane, plasma membrane, side of membrane
Pathways: Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, HS-GAG biosynthesis, HS-GAG degradation, Hedgehog ligand biogenesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Release of Hh-Np from the secreting cell, Retinoid metabolism and transport, Sensory Perception, Signal Transduction, Signaling by Hedgehog, Visual phototransduction
UniProt: Q8CAL5
Entrez ID: 103978
|
Does Knockout of Mug2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Mug2
|
cell cycle progression
|
breast epithelium
|
Gene: Mug2 (murinoglobulin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: endopeptidase inhibitor activity, peptidase inhibitor activity, protease binding, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: P28666
Entrez ID: 17837
|
Does Knockout of Pros1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Pros1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pros1 (protein S (alpha))
Type: protein-coding
Summary: This gene encodes a vitamin K-dependent protein with key roles in multiple biological processes including coagulation, apoptosis and vasculogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein which is secreted into the plasma. Mice lacking the encoded protein die in utero from a fulminant coagulopathy and associated hemorrhages. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: blood coagulation, fibrinolysis, hemostasis, negative regulation of coagulation, positive regulation of phagocytosis, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: calcium ion binding, protein-containing complex binding; CC: extracellular region, extracellular space, protein-containing complex
Pathways: Cell surface interactions at the vascular wall, Common Pathway of Fibrin Clot Formation, Complement and coagulation cascades - Mus musculus (mouse), Formation of Fibrin Clot (Clotting Cascade), Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Gamma-carboxylation of protein precursors, Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Hemostasis, Intrinsic Pathway of Fibrin Clot Formation, Metabolism of proteins, Platelet activation, signaling and aggregation, Platelet degranulation , Post-translational protein modification, Removal of aminoterminal propeptides from gamma-carboxylated proteins, Response to elevated platelet cytosolic Ca2+, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
UniProt: Q08761
Entrez ID: 19128
|
Does Knockout of Tmem70 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Tmem70
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tmem70 (transmembrane protein 70)
Type: protein-coding
Summary: Predicted to enable mitochondrial proton-transporting ATP synthase complex binding activity. Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrion. Is expressed in several structures, including brain; gut; nasal cavity epithelium; orbito-sphenoid; and urinary system. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 2. Orthologous to human TMEM70 (transmembrane protein 70). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial proton-transporting ATP synthase complex assembly, mitochondrial respiratory chain complex I assembly, protein complex oligomerization, protein homooligomerization; MF: mitochondrial proton-transporting ATP synthase complex binding; CC: membrane, mitochondrial crista, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways:
UniProt: Q921N7
Entrez ID: 70397
|
Does Knockout of Bmpr2 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,197
|
Knockout
|
Bmpr2
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Bmpr2 (bone morphogenetic protein receptor type 2)
Type: protein-coding
Summary: This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: BMP signaling pathway, MAPK cascade, activin receptor signaling pathway, angiogenesis, anterior/posterior pattern specification, aortic valve development, artery development, atrial septum morphogenesis, atrioventricular valve morphogenesis, blood vessel development, blood vessel remodeling, bone development, cardiac muscle tissue development, cell differentiation, cell fate specification, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to BMP stimulus, cellular response to growth factor stimulus, cellular response to starvation, chondrocyte development, endocardial cushion development, endochondral bone morphogenesis, endothelial cell apoptotic process, endothelial cell proliferation, limb development, lung alveolus development, lung development, lung vasculature development, lymphangiogenesis, lymphatic endothelial cell differentiation, maternal placenta development, mesoderm formation, mitral valve morphogenesis, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of cell proliferation involved in heart valve morphogenesis, negative regulation of chondrocyte proliferation, negative regulation of muscle cell differentiation, negative regulation of smooth muscle cell proliferation, negative regulation of systemic arterial blood pressure, negative regulation of vasoconstriction, osteoblast differentiation, outflow tract morphogenesis, outflow tract septum morphogenesis, pharyngeal arch artery morphogenesis, positive regulation of SMAD protein signal transduction, positive regulation of axon extension involved in axon guidance, positive regulation of bone mineralization, positive regulation of cartilage development, positive regulation of cell differentiation, positive regulation of epithelial cell migration, positive regulation of gene expression, positive regulation of locomotion, positive regulation of ossification, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, protein import into nucleus, proteoglycan biosynthetic process, pulmonary valve development, regulation of cell growth, regulation of cell population proliferation, regulation of lung blood pressure, regulation of multicellular organismal development, retina development in camera-type eye, retina vasculature development in camera-type eye, semi-lunar valve development, stem cell differentiation, tissue development, tricuspid valve morphogenesis, vasculature development, venous blood vessel development, ventricular septum morphogenesis; MF: ATP binding, BMP binding, BMP receptor activity, activin receptor activity, type II, cadherin binding, growth factor binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase binding, transferase activity, transforming growth factor beta receptor activity, transmembrane receptor protein serine/threonine kinase activity; CC: adherens junction, apical plasma membrane, axon, basal plasma membrane, caveola, cell body, cell junction, cell surface, clathrin-coated pit, dendrite, membrane, neuronal cell body, nucleoplasm, organelle, plasma membrane, postsynaptic density, receptor complex
Pathways: Axon guidance - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Signal Transduction, Signaling by BMP, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: O35607
Entrez ID: 12168
|
Does Knockout of Elavl3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Elavl3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Elavl3 (ELAV like RNA binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, nervous system development; MF: RNA binding, mRNA 3'-UTR AU-rich region binding, nucleic acid binding
Pathways:
UniProt: Q60900
Entrez ID: 15571
|
Does Knockout of Ccdc50 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Ccdc50
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ccdc50 (coiled-coil domain containing 50)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ubiquitin protein ligase binding; CC: ciliary basal body, cytoplasm, cytosol, microtubule cytoskeleton
Pathways:
UniProt: Q810U5
Entrez ID: 67501
|
Does Knockout of Usf2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Usf2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Usf2 (upstream transcription factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to glucose stimulus, glucose mediated signaling pathway, lactation, lipid homeostasis, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, bHLH transcription factor binding, double-stranded DNA binding, identical protein binding, protein binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways: ESR-mediated signaling, Estrogen-dependent gene expression, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q64705
Entrez ID: 22282
|
Does Knockout of Ermap in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Ermap
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ermap (erythroblast membrane-associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, regulation of cytokine production; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, cytosol, external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q9JLN5
Entrez ID: 27028
|
Does Knockout of Phf11d in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Phf11d
|
response to virus
|
Microglial Cell Line
|
Gene: Phf11d (PHD finger protein 11D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding; CC: nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: A6H5X4
Entrez ID: 219132
|
Does Knockout of Eif4g2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Eif4g2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Eif4g2 (eukaryotic translation initiation factor 4, gamma 2)
Type: protein-coding
Summary: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: negative regulation of autophagy, positive regulation of axon extension, positive regulation of cell growth, positive regulation of dendritic spine development, positive regulation of translation, regulation of translation, regulation of translational initiation, translation, translational initiation; MF: RNA binding, mRNA binding, protein binding, translation factor activity, RNA binding, translation initiation factor activity; CC: axon, cytoplasm, cytosol, eukaryotic translation initiation factor 4F complex, postsynaptic density
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, ISG15 antiviral mechanism, Immune System, Interferon Signaling, Viral myocarditis - Mus musculus (mouse)
UniProt: Q62448
Entrez ID: 13690
|
Does Knockout of Mylk2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Mylk2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mylk2 (myosin, light polypeptide kinase 2, skeletal muscle)
Type: protein-coding
Summary: Predicted to enable myosin light chain binding activity and myosin light chain kinase activity. Involved in skeletal muscle satellite cell differentiation. Acts upstream of or within neuromuscular synaptic transmission. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to human MYLK2 (myosin light chain kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cardiac muscle cell differentiation, cardiac muscle tissue morphogenesis, neuromuscular synaptic transmission, positive regulation of fast-twitch skeletal muscle fiber contraction, positive regulation of gene expression, regulation of MAPK cascade, regulation of muscle filament sliding, regulation of neuronal synaptic plasticity, signal transduction, skeletal muscle cell differentiation, skeletal muscle satellite cell differentiation, striated muscle contraction, synaptic vesicle transport, water transport; MF: ATP binding, calmodulin binding, kinase activity, myosin light chain binding, myosin light chain kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, dendrite, dendritic spine, neuronal cell body, nucleus, synapse, synaptic vesicle, terminal bouton
Pathways: Apelin signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q8VCR8
Entrez ID: 228785
|
Does Knockout of Mta2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Mta2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Mta2 (metastasis-associated gene family, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, chromosome organization, genomic imprinting, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell fate specification, regulation of fibroblast migration, regulation of stem cell differentiation; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone deacetylase activity, histone deacetylase binding, metal ion binding, protein binding, sequence-specific DNA binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity, zinc ion binding; CC: NuRD complex, catalytic complex, chromosome, telomeric region, histone deacetylase complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Signal Transduction, Transcriptional Regulation by TP53
UniProt: Q9R190
Entrez ID: 23942
|
Does Knockout of Tacr3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Tacr3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tacr3 (tachykinin receptor 3)
Type: protein-coding
Summary: This gene belongs to a family of genes that function as receptors for tachykinins. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, conditioned place preference, drinking behavior, positive regulation of blood pressure, positive regulation of flagellated sperm motility, positive regulation of heart rate, positive regulation of luteinizing hormone secretion, positive regulation of uterine smooth muscle contraction, regulation of dopamine metabolic process, regulation of feeding behavior, regulation of uterine smooth muscle contraction, response to cocaine, response to estradiol, signal transduction, tachykinin receptor signaling pathway, vagina development; MF: G protein-coupled receptor activity, tachykinin receptor activity; CC: axon terminus, dendrite membrane, dendritic spine head, dendritic spine membrane, membrane, neuronal cell body, neuronal cell body membrane, plasma membrane, sperm midpiece
Pathways: Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Tachykinin receptors bind tachykinins
UniProt: P47937
Entrez ID: 21338
|
Does Knockout of Mir125b-1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Mir125b-1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mir125b-1 (microRNA 125b-1)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cellular response to estrogen stimulus, cellular response to leukemia inhibitory factor, cellular response to mechanical stimulus, cellular response to tumor necrosis factor, common myeloid progenitor cell proliferation, hematopoietic stem cell differentiation, juxtaglomerular apparatus development, long-term synaptic potentiation, miRNA-mediated post-transcriptional gene silencing, ossification, positive regulation of gene expression, sensory perception of sound
Pathways: MicroRNAs in cancer - Mus musculus (mouse)
UniProt:
Entrez ID: 387236
|
Does Knockout of Zfp629 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Zfp629
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp629 (zinc finger protein 629)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q6A085
Entrez ID: 320683
|
Does Knockout of Caap1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Caap1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Caap1 (caspase activity and apoptosis inhibitor 1)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of apoptotic process. Orthologous to human CAAP1 (caspase activity and apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, regulation of apoptotic process
Pathways:
UniProt: Q8VDY9
Entrez ID: 67770
|
Does Knockout of Secisbp2l in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Secisbp2l
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Secisbp2l (SECIS binding protein 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: mRNA 3'-UTR binding, ribonucleoprotein complex binding, selenocysteine insertion sequence binding; CC: mitochondrion, ribonucleoprotein complex
Pathways:
UniProt: Q8C7M0, A2AQE2, F6QQ13
Entrez ID: 70354
|
Does Knockout of Gpr132 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Gpr132
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gpr132 (G protein-coupled receptor 132)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G1/S transition of mitotic cell cycle, negative regulation of G2/M transition of mitotic cell cycle, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Signal Transduction, Signaling by GPCR
UniProt: Q9Z282
Entrez ID: 56696
|
Does Knockout of Slc25a20 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Slc25a20
|
phagocytosis
|
macrophage
|
Gene: Slc25a20 (solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20)
Type: protein-coding
Summary: Predicted to enable O-acyl-L-carnitine transmembrane transporter activity and carnitine transmembrane transporter activity. Involved in carnitine shuttle. Acts upstream of or within in utero embryonic development. Located in mitochondrial inner membrane. Is expressed in cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Orthologous to human SLC25A20 (solute carrier family 25 member 20). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: (R)-carnitine transmembrane transport, O-acyl-L-carnitine transmembrane transport, carnitine shuttle, carnitine transmembrane transport, in utero embryonic development, lipid transport, mitochondrial transport; MF: (R)-carnitine transmembrane transporter activity, O-acyl-L-carnitine transmembrane transporter activity, carnitine:O-acyl-L-carnitine antiporter activity; CC: cytosol, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion
Pathways: Carnitine shuttle, Fatty acid metabolism, Metabolism, Metabolism of lipids, Thermogenesis - Mus musculus (mouse)
UniProt: Q9Z2Z6
Entrez ID: 57279
|
Does Knockout of Card10 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Card10
|
response to bacteria
|
renal medulla cell line
|
Gene: Card10 (caspase recruitment domain family, member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of NF-kappaB-inducing kinase activity, negative regulation of cell migration involved in sprouting angiogenesis, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein localization to nucleus, regulation of apoptotic process, regulation of immune response
Pathways: NF-kappa B signaling pathway - Mus musculus (mouse)
UniProt: P58660
Entrez ID: 105844
|
Does Knockout of Polr3b in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Polr3b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Polr3b (polymerase (RNA) III (DNA directed) polypeptide B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production, rRNA transcription, snRNA transcription by RNA polymerase III, transcription by RNA polymerase III; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, metal ion binding, nucleotidyltransferase activity, ribonucleoside binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, cytoplasm, cytosol, nuclear DNA-directed RNA polymerase complex, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: P59470
Entrez ID: 70428
|
Does Knockout of Cdsn in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Cdsn
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cdsn (corneodesmosin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid fibril formation, cell-cell adhesion, corneocyte desquamation, negative regulation of cornification, skin morphogenesis; MF: protein homodimerization activity; CC: cornified envelope, desmosome, extracellular region
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q7TPC1
Entrez ID: 386463
|
Does Knockout of Klra8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Klra8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Klra8 (killer cell lectin-like receptor, subfamily A, member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, response to virus; MF: carbohydrate binding, protein binding, signaling receptor activity; CC: cell surface, membrane, plasma membrane
Pathways: Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: Q60682
Entrez ID: 16639
|
Does Knockout of Rbmy in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Rbmy
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Rbmy (RNA binding motif protein, Y chromosome)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, hematopoietic progenitor cell differentiation, mRNA processing, positive regulation of mRNA splicing, via spliceosome; MF: RNA binding, identical protein binding, mRNA binding, nucleic acid binding; CC: male germ cell nucleus, nucleolus, nucleoplasm, nucleus, organelle, protein-containing complex, spliceosomal complex
Pathways:
UniProt: O35698
Entrez ID: 19657
|
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