prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ocstamp in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Ocstamp
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ocstamp (osteoclast stimulatory transmembrane protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cellular response to estrogen stimulus, cellular response to tumor necrosis factor, multinuclear osteoclast differentiation, positive regulation of macrophage fusion, positive regulation of osteoclast differentiation, positive regulation of osteoclast proliferation; CC: cellular_component, membrane
Pathways:
UniProt: Q9D611
Entrez ID: 74614
|
Does Knockout of Onecut1 in cardiac muscle cell line causally result in protein/peptide accumulation?
| 0
| 1,662
|
Knockout
|
Onecut1
|
protein/peptide accumulation
|
cardiac muscle cell line
|
Gene: Onecut1 (one cut domain, family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, Notch signaling pathway, anatomical structure morphogenesis, cell fate commitment, cilium assembly, endocrine pancreas development, endoderm development, enteroendocrine cell differentiation, epithelial cell development, glucose metabolic process, liver development, negative regulation of transforming growth factor beta receptor signaling pathway, pancreas development, pancreatic A cell differentiation, pancreatic D cell differentiation, positive regulation of cell migration, positive regulation of transcription by RNA polymerase II, regulation of cell-matrix adhesion, regulation of transcription by RNA polymerase II, spleen development, type B pancreatic cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways: Maturity onset diabetes of the young - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: O08755
Entrez ID: 15379
|
Does Knockout of Mir3113 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Mir3113
|
cell cycle progression
|
breast epithelium
|
Gene: Mir3113 (microRNA 3113)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100526542
|
Does Knockout of Vps26a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Vps26a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vps26a (VPS26 retromer complex component A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, intracellular protein transport, protein transport, retrograde transport, endosome to Golgi; CC: cytoplasm, cytosol, early endosome, endosome, endosome membrane, lysosome, membrane, retromer complex, retromer, cargo-selective complex, tubular endosome, vesicle
Pathways: Endocytosis - Mus musculus (mouse), Signal Transduction, Signaling by WNT, WNT ligand biogenesis and trafficking
UniProt: P40336
Entrez ID: 30930
|
Does Knockout of Usp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Usp1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Usp1 (ubiquitin specific peptidase 1)
Type: protein-coding
Summary: This gene encodes a member of the ubiquitin-specific peptidase family. The encoded protein acts as a catalytic subunit in a heterodimeric deubiquitinating enzyme complex that deubiquitinates Fanconi anemia, complementation group D2, and plays a role in homologous recombination-mediated DNA repair. Disruption of this gene is associated with a Fanconi anemia-like phenotype and genomic instability. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 3, 12, and 15. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: DNA damage response, DNA repair, cell surface receptor signaling pathway via JAK-STAT, monoubiquitinated protein deubiquitination, positive regulation of receptor signaling pathway via JAK-STAT, protein deubiquitination, proteolysis, regulation of DNA repair, regulation of protein stability, response to UV, skeletal system development; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cytosol, nucleoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Recognition of DNA damage by PCNA-containing replication complex
UniProt: Q8BJQ2
Entrez ID: 230484
|
Does Knockout of Zfp90 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 167
|
Knockout
|
Zfp90
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp90 (zinc finger protein 90)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA binding, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q61967
Entrez ID: 22751
|
Does Knockout of Miox in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Miox
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Miox (myo-inositol oxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inositol catabolic process; MF: NADP binding, alcohol dehydrogenase (NADP+) activity, ferric iron binding, inositol oxygenase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H; CC: cytoplasm, inclusion body
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Synthesis of IP2, IP, and Ins in the cytosol
UniProt: Q9QXN5
Entrez ID: 56727
|
Does Knockout of Ankrd49 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Ankrd49
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Ankrd49 (ankyrin repeat domain 49)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, positive regulation of DNA-templated transcription, spermatogenesis
Pathways:
UniProt: Q8VE42
Entrez ID: 56503
|
Does Knockout of B3gnt7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
B3gnt7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: B3gnt7 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: keratan sulfate proteoglycan biosynthetic process, poly-N-acetyllactosamine biosynthetic process, protein O-linked glycosylation, protein glycosylation; MF: UDP-glycosyltransferase activity, acetylglucosaminyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - keratan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q8K0J2
Entrez ID: 227327
|
Does Knockout of D5Ertd579e in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
D5Ertd579e
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: D5Ertd579e (DNA segment, Chr 5, ERATO Doi 579, expressed)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Orthologous to human KIAA0232 (KIAA0232). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: ATP binding, molecular_function, nucleotide binding
Pathways:
UniProt: Q80U59
Entrez ID: 320661
|
Does Knockout of Vmn1r80 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Vmn1r80
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Vmn1r80 (vomeronasal 1 receptor 80)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BR91, L7N1Z3
Entrez ID: 171238
|
Does Knockout of Zfand1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Zfand1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfand1 (zinc finger, AN1-type domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to arsenite ion, positive regulation of intracellular protein transport, stress granule disassembly; MF: metal ion binding, proteasome binding, zinc ion binding; CC: cytoplasm, cytoplasmic stress granule
Pathways:
UniProt: Q8BFR6
Entrez ID: 66361
|
Does Knockout of Stat2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Stat2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Stat2 (signal transducer and activator of transcription 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, defense response, defense response to virus, negative regulation of type I interferon-mediated signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of mitochondrial fission, regulation of protein phosphorylation, regulation of transcription by RNA polymerase II, response to peptide hormone, signal transduction, type I interferon-mediated signaling pathway; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, ubiquitin-like protein ligase binding; CC: ISGF3 complex, cytoplasm, cytosol, nucleus, plasma membrane
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: Q9QXJ2
Entrez ID: 20847
|
Does Knockout of Crnn in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Crnn
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Crnn (cornulin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-cell adhesion, cellular response to cytokine stimulus, positive regulation of cell cycle G1/S phase transition, positive regulation of keratinocyte proliferation, regulation of gene expression, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, response to heat; MF: calcium ion binding, calcium-dependent protein binding, metal ion binding, transition metal ion binding; CC: cytoplasm, membrane
Pathways:
UniProt: A0A0A6YXA1, D3YUU6
Entrez ID: 381457
|
Does Knockout of Zfp672 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Zfp672
|
response to virus
|
Microglial Cell Line
|
Gene: Zfp672 (zinc finger protein 672)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q99LH4
Entrez ID: 319475
|
Does Knockout of Kat5 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,557
|
Knockout
|
Kat5
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Kat5 (K(lysine) acetyltransferase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA double-strand break processing, DNA repair, DNA repair-dependent chromatin remodeling, aggrephagy, apoptotic process, attachment of mitotic spindle microtubules to kinetochore, cGAS/STING signaling pathway, cellular response to estradiol stimulus, cellular response to glucose starvation, cellular response to glucose stimulus, cellular response to oxygen-containing compound, cellular response to stress, chromatin organization, double-strand break repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, establishment of mitotic spindle orientation, germ cell development, immune system process, innate immune response, lipid droplet disassembly, membraneless organelle assembly, negative regulation of DNA-templated transcription, negative regulation of double-strand break repair via homologous recombination, negative regulation of interleukin-2 production, negative regulation of myoblast differentiation, negative regulation of transcription by RNA polymerase II, neural tube development, neurogenesis, nucleotide-excision repair, peptidyl-lysine acetylation, phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of aggrephagy, positive regulation of attachment of mitotic spindle microtubules to kinetochore, positive regulation of autophagy, positive regulation of circadian rhythm, positive regulation of double-strand break repair via homologous recombination, positive regulation of innate immune response, positive regulation of mitotic sister chromatid segregation, positive regulation of myoblast differentiation, positive regulation of regulatory T cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of triglyceride biosynthetic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein localization to site of double-strand break, protein targeting to vacuole involved in autophagy, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of chromatin organization, regulation of double-strand break repair, regulation of hematopoietic stem cell differentiation, regulation of transcription by RNA polymerase II, response to ionizing radiation, sperm DNA condensation, spermatid development, triglyceride biosynthetic process; MF: DNA-binding transcription factor binding, acyltransferase activity, chromatin binding, histone H2A acetyltransferase activity, histone H2AK5 acetyltransferase activity, histone H4 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, peptide 2-hydroxyisobutyryltransferase activity, peptide butyryltransferase activity, peptide crotonyltransferase activity, peptide lactyltransferase (CoA-dependent) activity, phospholipase binding, protein binding, protein-containing complex binding, protein-lysine-acetyltransferase activity, transcription coactivator activity, transferase activity, zinc ion binding; CC: H4 histone acetyltransferase complex, NuA4 histone acetyltransferase complex, Swr1 complex, chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, mitotic spindle pole, nuclear lumen, nucleolus, nucleoplasm, nucleosome, nucleus, perinuclear region of cytoplasm, piccolo histone acetyltransferase complex, protein-containing complex, site of double-strand break, spindle pole, transcription regulator complex
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, ESR-mediated signaling, Estrogen-dependent gene expression, Formation of the beta-catenin:TCF transactivating complex, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Sensing of DNA Double Strand Breaks, Signal Transduction, Signaling by Nuclear Receptors, Signaling by WNT, Spinocerebellar ataxia - Mus musculus (mouse), TCF dependent signaling in response to WNT, Transcriptional Regulation by TP53
UniProt: Q8CHK4
Entrez ID: 81601
|
Does Knockout of Rab5c in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Rab5c
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Rab5c (RAB5C, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytosis, endosomal transport, endosome organization, intracellular protein transport, plasma membrane to endosome transport, protein transport, regulation of endocytosis; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: early endosome, early endosome membrane, endocytic vesicle, endomembrane system, endosome, lipid droplet, melanosome, membrane, plasma membrane, synaptic vesicle membrane
Pathways: Amoebiasis - Mus musculus (mouse), Clathrin-mediated endocytosis, Endocytosis - Mus musculus (mouse), Golgi Associated Vesicle Biogenesis, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Phagosome - Mus musculus (mouse), Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Ras signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Vasopressin-regulated water reabsorption - Mus musculus (mouse), Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: P35278
Entrez ID: 19345
|
Does Knockout of Cenph in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Cenph
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Cenph (centromere protein H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, kinetochore assembly, kinetochore organization, mitotic cell cycle, mitotic spindle organization; MF: kinetochore binding, protein binding; CC: chromosome, chromosome, centromeric region, inner kinetochore, kinetochore, nucleolus, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9QYM8
Entrez ID: 26886
|
Does Knockout of Nanog in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Nanog
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Nanog (Nanog homeobox)
Type: protein-coding
Summary: The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cell dedifferentiation, cell differentiation, cellular response to erythropoietin, cellular response to rapamycin, embryonic pattern specification, endodermal cell fate specification, gene expression, gonad development, mesodermal cell fate commitment, multidimensional cell growth, negative regulation of BMP signaling pathway, negative regulation of cell fate commitment, negative regulation of endodermal cell fate specification, negative regulation of stem cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of mitotic cell cycle, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of stem cell division, regulation of transcription by RNA polymerase II, response to bisphenol A, response to retinoic acid, somatic stem cell population maintenance, stem cell differentiation, stem cell division, stem cell population maintenance, tissue regeneration; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, identical protein binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription factor binding; CC: chromatin, condensed chromosome, nucleolus, nucleoplasm, nucleus
Pathways: Proteoglycans in cancer - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: Q80Z64
Entrez ID: 71950
|
Does Knockout of Grb14 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Grb14
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Grb14 (growth factor receptor bound protein 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to insulin stimulus, insulin receptor signaling pathway, negative regulation of insulin receptor signaling pathway, negative regulation of meiotic cell cycle process involved in oocyte maturation, signal transduction; MF: molecular adaptor activity, phosphoprotein binding, protein binding, protein-macromolecule adaptor activity, receptor tyrosine kinase binding; CC: cytoplasm, endosome, endosome membrane, membrane, plasma membrane
Pathways: Cell surface interactions at the vascular wall, Hemostasis, Tie2 Signaling
UniProt: Q9JLM9
Entrez ID: 50915
|
Does Knockout of Fbxo47 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Fbxo47
|
cell proliferation
|
Regulatory T cell
|
Gene: Fbxo47 (F-box protein 47)
Type: protein-coding
Summary: Orthologous to human FBXO47 (F-box protein 47). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A2A6H3
Entrez ID: 72973
|
Does Knockout of Azin2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Azin2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Azin2 (antizyme inhibitor 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: alpha-amino acid metabolic process, negative regulation of protein catabolic process, ornithine metabolic process, polyamine biosynthetic process, positive regulation of catalytic activity, positive regulation of polyamine transmembrane transport, putrescine biosynthetic process from arginine, via ornithine, trans-Golgi network membrane organization; MF: catalytic activity, ornithine decarboxylase activator activity, ornithine decarboxylase activity, protein binding; CC: Golgi apparatus, axon, cell projection, cis-Golgi network, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, granular vesicle, membrane, mitochondrion, nucleus, perikaryon, perinuclear region of cytoplasm, trans-Golgi network, transport vesicle
Pathways: Agmatine biosynthesis, Arginine and proline metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, putrescine biosynthesis III, spermine biosynthesis II
UniProt: Q8BVM4
Entrez ID: 242669
|
Does Knockout of Hsfy2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Hsfy2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hsfy2 (heat shock transcription factor, Y-linked 2)
Type: protein-coding
Summary: Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be located in cytosol and nucleoplasm. Orthologous to several human genes including HSFY2 (heat shock transcription factor Y-linked 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q80Y37
Entrez ID: 71066
|
Does Knockout of Plekhb2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Plekhb2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Plekhb2 (pleckstrin homology domain containing, family B (evectins) member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endosome, membrane, recycling endosome membrane
Pathways:
UniProt: Q9QZC7
Entrez ID: 226971
|
Does Knockout of Slc17a8 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Slc17a8
|
phagocytosis
|
macrophage
|
Gene: Slc17a8 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate import, L-glutamate transmembrane transport, chloride transmembrane transport, chloride transport, cochlea development, monoatomic ion transmembrane transport, monoatomic ion transport, neural retina development, neurotransmitter loading into synaptic vesicle, neurotransmitter transport, phosphate ion homeostasis, phosphate ion transport, positive regulation of glutamate uptake involved in transmission of nerve impulse, regulation of acetylcholine uptake, regulation of synapse structure or activity, sensory perception of sound, sodium ion transmembrane transport, sodium ion transport, sodium-dependent phosphate transport, synaptic transmission, glutamatergic, transmembrane transport; MF: L-glutamate transmembrane transporter activity, L-glutamate uniporter activity, chloride channel activity, neurotransmitter transmembrane transporter activity, sodium:phosphate symporter activity, symporter activity, transmembrane transporter activity; CC: apical dendrite, axon terminus, basal dendrite, chloride channel complex, clathrin-sculpted glutamate transport vesicle membrane, cytoplasmic vesicle, dendrite, excitatory synapse, glial limiting end-foot, glutamatergic synapse, membrane, multivesicular body, neuron projection, neuronal cell body, pericellular basket, perikaryon, plasma membrane, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways: Glutamatergic synapse - Mus musculus (mouse), Nicotine addiction - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic vesicle cycle - Mus musculus (mouse), Transport of small molecules
UniProt: Q8BFU8
Entrez ID: 216227
|
Does Knockout of Tap1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,141
|
Knockout
|
Tap1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Tap1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP))
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: adaptive immune response, antigen processing and presentation of endogenous peptide antigen via MHC class I, cytosol to endoplasmic reticulum transport, defense response, immune system process, peptide antigen assembly with MHC class I protein complex, peptide transport, protection from natural killer cell mediated cytotoxicity, protein transport, transmembrane transport; MF: ABC-type peptide antigen transporter activity, ABC-type transporter activity, ADP binding, ATP binding, ATP hydrolysis activity, MHC class I protein binding, MHC class Ib protein binding, TAP1 binding, TAP2 binding, metal ion binding, nucleotide binding, peptide antigen binding, peptide transmembrane transporter activity, protein homodimerization activity, protein-containing complex binding, tapasin binding; CC: MHC class I peptide loading complex, TAP complex, centriolar satellite, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, organelle membrane, phagocytic vesicle membrane
Pathways: ABC transporters - Mus musculus (mouse), Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, ER-Phagosome pathway, Epstein-Barr virus infection - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Phagosome - Mus musculus (mouse), Primary immunodeficiency - Mus musculus (mouse)
UniProt: P21958
Entrez ID: 21354
|
Does Knockout of Cst8 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Cst8
|
cell proliferation
|
Regulatory T cell
|
Gene: Cst8 (cystatin 8 (cystatin-related epididymal spermatogenic))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: cysteine-type endopeptidase inhibitor activity, peptidase inhibitor activity; CC: cell surface, cytoplasm, extracellular region
Pathways:
UniProt: P32766
Entrez ID: 13012
|
Does Knockout of Klrb1f in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Klrb1f
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Klrb1f (killer cell lectin-like receptor subfamily B member 1F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, protein binding, signaling receptor activity; CC: cell surface, membrane, plasma membrane
Pathways: Malaria - Mus musculus (mouse)
UniProt: Q8VD98
Entrez ID: 232408
|
Does Knockout of Grwd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Grwd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Grwd1 (glutamate-rich WD repeat containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, nucleosome assembly, nucleosome disassembly, ribosome biogenesis; MF: DNA replication origin binding, chromatin binding, histone binding; CC: chromosome, cytosol, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q810D6
Entrez ID: 101612
|
Does Knockout of Pim1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Pim1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pim1 (proviral integration site 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular detoxification, cellular response to amino acid starvation, cellular response to nutrient levels, cellular response to type II interferon, cytolysis in another organism, defense response to bacterium, negative regulation of TORC1 signaling, negative regulation of apoptotic process, negative regulation of innate immune response, non-canonical inflammasome complex assembly, positive regulation of DNA-templated transcription, positive regulation of TORC1 signaling, positive regulation of brown fat cell differentiation, positive regulation of cardiac muscle cell proliferation, positive regulation of cardioblast proliferation, protein phosphorylation, protein stabilization, regulation of hematopoietic stem cell proliferation, regulation of mitotic cell cycle, regulation of transmembrane transporter activity, vitamin D receptor signaling pathway; MF: ATP binding, kinase activity, manganese ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, ribosomal small subunit binding, transferase activity; CC: cytoplasm, cytosol, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: P06803
Entrez ID: 18712
|
Does Knockout of Myh11 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Myh11
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Myh11 (myosin, heavy polypeptide 11, smooth muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actomyosin structure organization, cardiac muscle cell development, elastic fiber assembly, skeletal muscle myosin thick filament assembly, smooth muscle contraction; MF: ATP binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding, structural constituent of muscle; CC: brush border, cytoplasm, melanosome, muscle myosin complex, myofibril, myosin II complex, myosin complex, myosin filament, smooth muscle contractile fiber, stress fiber
Pathways: Regulation of actin cytoskeleton - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse)
UniProt: A0A2R8VHF9, E9QPE7, A0A338P6K2
Entrez ID: 17880
|
Does Knockout of Tvp23b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Tvp23b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tvp23b (trans-golgi network vesicle protein 23B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein secretion, vesicle-mediated transport; CC: Golgi membrane, membrane
Pathways:
UniProt: Q9D8T4
Entrez ID: 67510
|
Does Knockout of Pgm5 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Pgm5
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pgm5 (phosphoglucomutase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cell adhesion, myofibril assembly, striated muscle tissue development; MF: magnesium ion binding, phosphoglucomutase activity, protein binding; CC: Z disc, adherens junction, anchoring junction, cell-substrate junction, costamere, cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, dystrophin-associated glycoprotein complex, focal adhesion, intercalated disc, membrane, plasma membrane, sarcolemma, spot adherens junction, stress fiber
Pathways: GDP-glucose biosynthesis, UDP-glucose conversion, glucose and glucose-1-phosphate degradation, glycogen degradation II, glycogen degradation III, starch degradation
UniProt: Q8BZF8
Entrez ID: 226041
|
Does Knockout of Grid1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Grid1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Grid1 (glutamate receptor, ionotropic, delta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ionotropic glutamate receptor signaling pathway, modulation of chemical synaptic transmission, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of synaptic plasticity, phospholipase C-activating G protein-coupled receptor signaling pathway, regulation of postsynapse organization, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of postsynaptic membrane potential, social behavior, synaptic signaling via neuropeptide, synaptic transmission, glutamatergic; MF: AMPA glutamate receptor activity, G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential, GABA receptor activity, identical protein binding, ligand-gated monoatomic ion channel activity, metal ion binding, monoatomic ion channel activity, protein binding, signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: AMPA glutamate receptor complex, GABA-ergic synapse, dendritic spine, glutamatergic synapse, membrane, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse, trans-synaptic protein complex
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse)
UniProt: Q61627
Entrez ID: 14803
|
Does Knockout of Slc10a6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Slc10a6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc10a6 (solute carrier family 10 (sodium/bile acid cotransporter family), member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid and bile salt transport, lipid transport, monoatomic ion transport, sodium ion transport, sodium-dependent organic anion transport, transmembrane transport; MF: bile acid:sodium symporter activity, sodium-dependent organic anion transmembrane transporter activity, symporter activity
Pathways: SLC-mediated bile acid transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: Q9CXB2
Entrez ID: 75750
|
Does Knockout of Tas2r131 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Tas2r131
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tas2r131 (taste receptor, type 2, member 131)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, molecular_function; CC: membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse)
UniProt: Q7M708
Entrez ID: 387356
|
Does Knockout of Gm5797 in small cell lung cancer causally result in cell proliferation?
| 1
| 1,714
|
Knockout
|
Gm5797
|
cell proliferation
|
small cell lung cancer
|
Gene: Gm5797 (predicted gene 5797)
Type: protein-coding
Summary: predicted gene 5797
Gene Ontology:
Pathways:
UniProt: Q5BKP9
Entrez ID: 545013
|
Does Knockout of Ppp2cb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Ppp2cb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ppp2cb (protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic mitochondrial changes, mitotic cell cycle, negative regulation of Ras protein signal transduction, negative regulation of canonical NF-kappaB signal transduction, negative regulation of gene expression, negative regulation of tumor necrosis factor-mediated signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of gene expression, regulation of microtubule polymerization, response to antibiotic, response to endoplasmic reticulum stress, response to hydrogen peroxide, response to lead ion; MF: hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, transmembrane transporter binding; CC: FAR/SIN/STRIPAK complex, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, nucleus, protein phosphatase type 2A complex, spindle pole
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Antiviral mechanism by IFN-stimulated genes, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Beta-catenin phosphorylation cascade, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chagas disease - Mus musculus (mouse), Co-inhibition by CTLA4, Co-stimulation by CD28, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin D associated events in G1, Cytokine Signaling in Immune system, DARPP-32 events, Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Dopaminergic synapse - Mus musculus (mouse), E2F mediated regulation of DNA replication, EML4 and NUDC in mitotic spindle formation, ERK/MAPK targets, ERKs are inactivated, G alpha (i) signalling events, G1 Phase, G1/S Transition, G2/M Transition, GPCR downstream signalling, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, Hepatitis C - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Innate Immune System, Interferon Signaling, Interleukin-17 signaling, Intracellular signaling by second messengers, Long-term depression - Mus musculus (mouse), M Phase, MAP kinase activation, MAPK family signaling cascades, MAPK targets/ Nuclear events mediated by MAP kinases, MAPK1/MAPK3 signaling, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of MAPK pathway, Negative regulation of the PI3K/AKT network, Nuclear Events (kinase and transcription factor activation), Oocyte meiosis - Mus musculus (mouse), Opioid Signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PKR-mediated signaling, Platelet homeostasis, Platelet sensitization by LDL, RAF activation, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Sphingolipid signaling pathway - Mus musculus (mouse), Spry regulation of FGF signaling, TCF dependent signaling in response to WNT, TGF-beta signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Tight junction - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcriptional Regulation by TP53, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P62715
Entrez ID: 19053
|
Does Knockout of Cdk6 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Cdk6
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cdk6 (cyclin dependent kinase 6)
Type: protein-coding
Summary: This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: DNA damage response, G1/S transition of mitotic cell cycle, Notch signaling pathway, T cell differentiation in thymus, cell dedifferentiation, cell differentiation, cell division, gliogenesis, hematopoietic progenitor cell differentiation, hematopoietic stem cell differentiation, hemopoiesis, negative regulation of cell cycle, negative regulation of cellular senescence, negative regulation of epithelial cell proliferation, negative regulation of monocyte differentiation, negative regulation of myeloid cell differentiation, negative regulation of osteoblast differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of cell-matrix adhesion, positive regulation of fibroblast proliferation, positive regulation of gene expression, regulation of G2/M transition of mitotic cell cycle, regulation of cell population proliferation, regulation of erythrocyte differentiation, regulation of gene expression, regulation of hematopoietic stem cell differentiation, response to virus, signal transduction, type B pancreatic cell development; MF: ATP binding, FBXO family protein binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, centrosome, cyclin D1-CDK6 complex, cyclin D2-CDK6 complex, cyclin D3-CDK6 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, ruffle
Pathways: Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cyclin D associated events in G1, Drug-mediated inhibition of CDK4/CDK6 activity, Epstein-Barr virus infection - Mus musculus (mouse), G1 Phase, Gene expression (Transcription), Generic Transcription Pathway, Glioma - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Non-small cell lung cancer - Mus musculus (mouse), Oncogene Induced Senescence, Oxidative Stress Induced Senescence, PI3K-Akt signaling pathway - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of RUNX1 Expression and Activity, Senescence-Associated Secretory Phenotype (SASP), Small cell lung cancer - Mus musculus (mouse), Transcriptional regulation by RUNX1, Viral carcinogenesis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: Q64261
Entrez ID: 12571
|
Does Knockout of Tnpo2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Tnpo2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tnpo2 (transportin 2 (importin 3, karyopherin beta 2b))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, negative regulation of muscle cell differentiation, nucleocytoplasmic transport, protein import into nucleus, protein transport; MF: nuclear import signal receptor activity, nuclear localization sequence binding, protein binding, small GTPase binding; CC: cytoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q99LG2
Entrez ID: 212999
|
Does Knockout of Angel1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Angel1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Angel1 (angel homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: catalytic activity, eukaryotic initiation factor 4E binding, mRNA 3'-UTR binding, protein domain specific binding; CC: cis-Golgi network, cytosol, endoplasmic reticulum, mitochondrial outer membrane, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q8VCU0
Entrez ID: 68737
|
Does Knockout of Zcchc8 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Zcchc8
|
phagocytosis
|
macrophage
|
Gene: Zcchc8 (zinc finger, CCHC domain containing 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA processing; MF: RNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: TRAMP complex, catalytic step 2 spliceosome, nuclear body, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Nuclear RNA decay
UniProt: Q9CYA6
Entrez ID: 70650
|
Does Knockout of Ppdpf in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Ppdpf
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ppdpf (pancreatic progenitor cell differentiation and proliferation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TOR signaling, TORC1 signaling, cell differentiation, liver development
Pathways:
UniProt: Q9CR37
Entrez ID: 66496
|
Does Knockout of Qtrt1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Qtrt1
|
response to virus
|
Microglial Cell Line
|
Gene: Qtrt1 (queuine tRNA-ribosyltransferase catalytic subunit 1)
Type: protein-coding
Summary: Enables tRNA-guanosine(34) queuine transglycosylase activity. Involved in tRNA-guanine transglycosylation. Located in cytoplasmic side of mitochondrial outer membrane and nucleus. Part of protein-containing complex. Colocalizes with mitochondrion. Is expressed in several structures, including alimentary system; facial bone primordium; nervous system; respiratory system; and urinary system. Orthologous to human QTRT1 (queuine tRNA-ribosyltransferase catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: tRNA modification, tRNA processing, tRNA wobble guanine modification; MF: glycosyltransferase activity, metal ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity, tRNA-guanosine(34) queuine transglycosylase activity, transferase activity; CC: cytoplasm, cytoplasmic side of mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion, nucleus, protein-containing complex, tRNA-guanine transglycosylase complex, transferase complex
Pathways:
UniProt: Q9JMA2
Entrez ID: 60507
|
Does Knockout of Slc6a13 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Slc6a13
|
cell proliferation
|
Regulatory T cell
|
Gene: Slc6a13 (solute carrier family 6 (neurotransmitter transporter, GABA), member 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid import across plasma membrane, amino acid transport, creatine transmembrane transport, gamma-aminobutyric acid import, monocarboxylic acid transport, neurotransmitter transport, sodium ion transmembrane transport, taurine transmembrane transport; MF: amino acid binding, amino acid transmembrane transporter activity, amino acid:sodium symporter activity, creatine transmembrane transporter activity, gamma-aminobutyric acid transmembrane transporter activity, gamma-aminobutyric acid:sodium:chloride symporter activity, monocarboxylic acid transmembrane transporter activity, symporter activity, taurine:sodium symporter activity; CC: basolateral plasma membrane, cell projection, membrane, plasma membrane
Pathways: GABA synthesis, release, reuptake and degradation, GABAergic synapse - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, Reuptake of GABA, SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules
UniProt: P31649
Entrez ID: 14412
|
Does Knockout of Smim12 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Smim12
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Smim12 (small integral membrane protein 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q78RX3
Entrez ID: 80284
|
Does Knockout of Tlcd2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Tlcd2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Tlcd2 (TLC domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: membrane assembly, phospholipid homeostasis, plasma membrane organization, regulation of membrane lipid distribution; CC: membrane, plasma membrane
Pathways:
UniProt: Q8VC26
Entrez ID: 380712
|
Does Knockout of Nsl1 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Nsl1
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Nsl1 (NSL1, MIS12 kinetochore complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, mitotic sister chromatid segregation; CC: MIS12/MIND type complex, chromosome, chromosome, centromeric region, kinetochore, nuclear speck, nucleus, outer kinetochore, spindle pole
Pathways:
UniProt: E9Q3W6, E9QME3, D3Z4S2
Entrez ID: 381318
|
Does Knockout of Zfp54 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Zfp54
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Zfp54 (zinc finger protein 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: E9PW05
Entrez ID: 22712
|
Does Knockout of Ecd in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Ecd
|
response to virus
|
Microglial Cell Line
|
Gene: Ecd (ecdysoneless cell cycle regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, fibroblast proliferation, mRNA processing, positive regulation of transcription by RNA polymerase II, regulation of G1/S transition of mitotic cell cycle; MF: histone acetyltransferase binding, protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9CS74
Entrez ID: 70601
|
Does Knockout of Fam53b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Fam53b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam53b (family with sequence similarity 53, member B)
Type: protein-coding
Summary: Predicted to be involved in positive regulation of canonical Wnt signaling pathway and protein import into nucleus. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; retina nuclear layer; skeletal muscle tissue; skin; and submandibular gland. Orthologous to human FAM53B (family with sequence similarity 53 member B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, protein import into nucleus, regulation of canonical Wnt signaling pathway; CC: nucleus
Pathways:
UniProt: Q8BGR5
Entrez ID: 77938
|
Does Knockout of Aff2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Aff2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Aff2 (AF4/FMR2 family, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, learning or memory, mRNA processing, negative regulation of gene expression, nuclear speck organization, regulation of RNA splicing, regulation of gene expression; MF: G-quadruplex RNA binding, RNA binding; CC: nuclear speck, nucleus, super elongation complex
Pathways:
UniProt: O55112
Entrez ID: 14266
|
Does Knockout of Rp1l1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Rp1l1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Rp1l1 (retinitis pigmentosa 1 homolog like 1)
Type: protein-coding
Summary: This gene encodes a member of the doublecortin family. This protein is a retinal-specific protein. It contains two N-terminal doublecortin domains, which can assemble and stabilize axonemal microtubules, but lacks the C-terminal repetitive regions including the 16aa repeat found in human RP1L1. This protein and the RP1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: axoneme assembly, cell projection organization, intracellular signal transduction, photoreceptor cell development, photoreceptor cell maintenance, photoreceptor cell outer segment organization, retina development in camera-type eye, visual perception; CC: axoneme, cell projection, cilium, cytoplasm, cytoskeleton, photoreceptor connecting cilium, photoreceptor outer segment
Pathways:
UniProt: Q8CGM2
Entrez ID: 271209
|
Does Knockout of Ino80e in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Ino80e
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ino80e (INO80 complex subunit E)
Type: protein-coding
Summary: Predicted to be involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Ino80 complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human INO80E (INO80 complex subunit E). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromatin remodeling, positive regulation of DNA-templated transcription, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization; CC: Ino80 complex, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: A0A0U1RPF6, Q8R359, D3Z3H2, A0A0U1RP99, D3YV78, A0A0U1RQ91, A0A0U1RPS2, D3Z3H0, A0A0U1RNZ5, A0A0U1RP78
Entrez ID: 233875
|
Does Knockout of Hoxa9 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Hoxa9
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Hoxa9 (homeobox A9)
Type: protein-coding
Summary: This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of similar genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important for hematopoeisis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: DNA-templated transcription, anterior/posterior pattern specification, definitive hemopoiesis, embryonic forelimb morphogenesis, embryonic skeletal system development, embryonic skeletal system morphogenesis, endothelial cell activation, male gonad development, mammary gland development, negative regulation of myeloid cell differentiation, positive regulation of transcription by RNA polymerase II, proximal/distal pattern formation, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II, single fertilization, skeletal system development, spermatogenesis, uterus development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, enzyme binding, protein binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleoplasm, nucleus, transcription regulator complex
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P09631
Entrez ID: 15405
|
Does Knockout of Ell3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Ell3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ell3 (elongation factor RNA polymerase II-like 3)
Type: protein-coding
Summary: Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of epithelial to mesenchymal transition; and transcription by RNA polymerase II. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of cell population proliferation; and positive regulation of neurogenesis. Located in nucleus. Is expressed in embryo endoderm and olfactory epithelium. Orthologous to human ELL3 (elongation factor for RNA polymerase II 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA-templated transcription elongation, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of signal transduction by p53 class mediator, positive regulation of DNA-templated transcription, elongation, positive regulation of neural precursor cell proliferation, positive regulation of neurogenesis, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of epithelial to mesenchymal transition, snRNA transcription by RNA polymerase II, stem cell differentiation, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: cis-regulatory region sequence-specific DNA binding, protein binding; CC: cell junction, chromosome, cytosol, nuclear speck, nucleolus, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q80VR2
Entrez ID: 269344
|
Does Knockout of Npm1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Npm1
|
cell cycle progression
|
breast epithelium
|
Gene: Npm1 (nucleophosmin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, cell volume homeostasis, cellular response to UV, cellular senescence, centrosome cycle, chromatin remodeling, cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), intracellular protein localization, macrophage differentiation, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell population proliferation, negative regulation of centrosome duplication, negative regulation of epithelial cell proliferation, negative regulation of gene expression, negative regulation of mRNA splicing, via spliceosome, negative regulation of neuron apoptotic process, negative regulation of protein kinase activity by regulation of protein phosphorylation, nucleocytoplasmic transport, nucleosome assembly, positive regulation of DNA metabolic process, positive regulation of DNA replication, positive regulation of DNA-templated transcription, positive regulation of biosynthetic process, positive regulation of cell cycle G2/M phase transition, positive regulation of cell population proliferation, positive regulation of centrosome duplication, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein localization to nucleolus, positive regulation of protein ubiquitination, positive regulation of transcription by RNA polymerase II, positive regulation of translation, post-transcriptional regulation of gene expression, protein import into nucleus, protein stabilization, rRNA transcription, regulation of DNA damage response, signal transduction by p53 class mediator, regulation of cell cycle, regulation of cell growth, regulation of cell population proliferation, regulation of centriole replication, regulation of centrosome duplication, regulation of eIF2 alpha phosphorylation by dsRNA, regulation of mRNA stability involved in cellular response to UV, regulation of neuron apoptotic process, regulation of protein stability, ribosomal large subunit biogenesis, ribosomal large subunit export from nucleus, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus; MF: ATP binding, DNA binding, DNA-binding transcription factor binding, NF-kappaB binding, RNA binding, Tat protein binding, chromatin binding, core promoter sequence-specific DNA binding, enzyme binding, histone binding, identical protein binding, molecular adaptor activity, nucleic acid binding, p53 binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding, protein homodimerization activity, protein kinase B binding, protein kinase binding, protein kinase inhibitor activity, rRNA binding, ribosomal large subunit binding, ribosomal small subunit binding, transcription coactivator activity, unfolded protein binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, granular component, large ribosomal subunit, nuclear matrix, nuclear speck, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, ribonucleoprotein complex, small ribosomal subunit, spindle pole centrosome
Pathways: Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Chromosome Maintenance, Cytokine Signaling in Immune system, Deposition of new CENPA-containing nucleosomes at the centromere, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Interferon Signaling, Metabolism of proteins, Nucleosome assembly, PKR-mediated signaling, Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: Q61937
Entrez ID: 18148
|
Does Knockout of Faiml in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Faiml
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Faiml (Fas apoptotic inhibitory molecule like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, regulation of signal transduction; CC: cellular_component, cytoplasm
Pathways:
UniProt: J3QPY3
Entrez ID: 623459
|
Does Knockout of Morc2b in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Morc2b
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Morc2b (microrchidia 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, chromatin remodeling, constitutive heterochromatin formation, double-strand break repair involved in meiotic recombination, gamete generation, homologous chromosome pairing at meiosis, transposable element silencing by heterochromatin formation; MF: ATP binding, ATP hydrolysis activity, chromatin binding, hydrolase activity, identical protein binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, zinc ion binding; CC: cytoplasm, cytosol, heterochromatin, nuclear matrix, nucleoplasm, nucleus
Pathways:
UniProt: Q8C5W4
Entrez ID: 240069
|
Does Knockout of Hagh in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Hagh
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Hagh (hydroxyacyl glutathione hydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutathione biosynthetic process, glutathione metabolic process, methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; MF: hydrolase activity, hydroxyacylglutathione hydrolase activity, metal ion binding; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), methylglyoxal degradation I
UniProt: Q99KB8
Entrez ID: 14651
|
Does Knockout of Cdca7 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Cdca7
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Cdca7 (cell division cycle associated 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, regulation of DNA-templated transcription, regulation of cell population proliferation; MF: hemi-methylated DNA-binding, molecular_function; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9D0M2
Entrez ID: 66953
|
Does Knockout of Cyp4x1 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Cyp4x1
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Cyp4x1 (cytochrome P450, family 4, subfamily x, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, lipid metabolic process; MF: anandamide 14,15 epoxidase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Serotonergic synapse - Mus musculus (mouse)
UniProt: Q6A152
Entrez ID: 81906
|
Does Knockout of Agpat1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Agpat1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Agpat1 (1-acylglycerol-3-phosphate O-acyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, lipid metabolic process, phosphatidic acid biosynthetic process, phospholipid biosynthetic process, positive regulation of cytokine production; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, Fat digestion and absorption - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PA, phosphatidylglycerol biosynthesis I (plastidic), phosphatidylglycerol biosynthesis II (non-plastidic), phospholipid biosynthesis I, triacylglycerol biosynthesis
UniProt: O35083
Entrez ID: 55979
|
Does Knockout of Snapc5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Snapc5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Snapc5 (small nuclear RNA activating complex, polypeptide 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III, transcription by RNA polymerase II, transcription initiation at RNA polymerase III promoter; MF: RNA polymerase II general transcription initiation factor activity, RNA polymerase III general transcription initiation factor activity; CC: nuclear body, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: Q8R2K7
Entrez ID: 330959
|
Does Knockout of Chek2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Chek2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Chek2 (checkpoint kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, G2/M transition of mitotic cell cycle, apoptotic process, autophagosome assembly, cell division, cellular response to bisphenol A, cellular response to gamma radiation, cellular response to stress, cellular response to xenobiotic stimulus, double-strand break repair, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, mitotic DNA damage checkpoint signaling, mitotic intra-S DNA damage checkpoint signaling, mitotic spindle assembly, negative regulation of DNA damage checkpoint, positive regulation of DNA-templated transcription, positive regulation of anoikis, positive regulation of autophagosome assembly, protein K63-linked ubiquitination, protein autophosphorylation, protein catabolic process, protein stabilization, regulation of DNA-templated transcription, regulation of autophagosome assembly, regulation of protein catabolic process, response to gamma radiation, response to glycoside, response to oxidative stress, response to starvation, signal transduction in response to DNA damage, thymocyte apoptotic process; MF: ATP binding, identical protein binding, kinase activity, metal ion binding, nucleotide binding, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin protein ligase binding; CC: Golgi apparatus, PML body, chromosome, telomeric region, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, G1/S DNA Damage Checkpoints, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Stabilization of p53, Transcriptional Regulation by TP53, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, p53 signaling pathway - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9Z265
Entrez ID: 50883
|
Does Knockout of Mup21 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Mup21
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Mup21 (major urinary protein 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, odorant binding, pheromone binding, small molecule binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q80YX8
Entrez ID: 381531
|
Does Knockout of Stx3 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Stx3
|
phagocytosis
|
macrophage
|
Gene: Stx3 (syntaxin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytic insertion of neurotransmitter receptor to postsynaptic membrane, exocytosis, intracellular protein transport, long-term synaptic potentiation, membrane fusion, modulation of chemical synaptic transmission, neuron projection development, neurotransmitter transport, organelle membrane fusion, positive regulation of cell adhesion, positive regulation of cell population proliferation, positive regulation of chemotaxis, positive regulation of protein localization to cell surface, positive regulation of protein localization to plasma membrane, regulation of gene expression, vesicle docking, vesicle fusion, vesicle-mediated transport, vesicle-mediated transport in synapse; MF: SNAP receptor activity, SNARE binding, arachidonate binding, protein binding; CC: SNARE complex, Schaffer collateral - CA1 synapse, apical plasma membrane, azurophil granule, cell projection, cell-cell junction, dendrite, endomembrane system, glutamatergic synapse, growth cone, lamellipodium, melanosome, membrane, neuron projection, photoreceptor cell terminal bouton, photoreceptor inner segment, photoreceptor outer segment, plasma membrane, plasma membrane bounded cell projection, postsynapse, presynapse, presynaptic membrane, ribbon synapse, secretory granule, specific granule, synaptic vesicle, zymogen granule membrane
Pathways: Cytokine Signaling in Immune system, Immune System, Other interleukin signaling, SNARE interactions in vesicular transport - Mus musculus (mouse), Signaling by Interleukins, Synaptic vesicle cycle - Mus musculus (mouse)
UniProt: Q64704
Entrez ID: 20908
|
Does Knockout of Drd1 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Drd1
|
response to bacteria
|
renal medulla cell line
|
Gene: Drd1 (dopamine receptor D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import, G protein-coupled dopamine receptor signaling pathway, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, adult walking behavior, associative learning, astrocyte development, behavioral fear response, behavioral response to cocaine, calcium-mediated signaling, cellular response to catecholamine stimulus, cerebral cortex GABAergic interneuron migration, conditioned taste aversion, dentate gyrus development, dopamine transport, eating behavior, feeding behavior, grooming behavior, habituation, hippocampus development, intracellular protein transport, learning, locomotory behavior, long-term synaptic depression, long-term synaptic potentiation, maternal behavior, mating behavior, memory, modification of postsynaptic structure, muscle contraction, negative regulation of cell migration, negative regulation of cellular response to hypoxia, negative regulation of circadian sleep/wake cycle, sleep, negative regulation of synaptic transmission, neuronal action potential, operant conditioning, peristalsis, phospholipase C-activating dopamine receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of feeding behavior, positive regulation of long-term synaptic potentiation, positive regulation of membrane potential, positive regulation of neuron migration, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of synaptic transmission, glutamatergic, postsynaptic modulation of chemical synaptic transmission, presynaptic modulation of chemical synaptic transmission, protein import into nucleus, regulation of dopamine metabolic process, regulation of monoatomic ion transport, regulation of vasoconstriction, response to amphetamine, response to cocaine, response to xenobiotic stimulus, sensitization, signal transduction, social behavior, striatum development, synaptic transmission, dopaminergic, temperature homeostasis, transmission of nerve impulse, vasodilation, visual learning; MF: ATPase binding, D3 dopamine receptor binding, G protein-coupled receptor activity, G-protein alpha-subunit binding, angiotensin receptor binding, arrestin family protein binding, dopamine binding, dopamine neurotransmitter receptor activity, dopamine neurotransmitter receptor activity, coupled via Gs, heterocyclic compound binding, heterotrimeric G-protein binding, protein binding, protein phosphatase binding, protein-containing complex binding, signaling receptor binding; CC: G protein-coupled receptor complex, GABA-ergic synapse, axon, axon terminus, caveola, cell projection, cell surface, ciliary membrane, cilium, dendrite, dendritic shaft, dendritic spine, dendritic spine head, dendritic spine neck, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, membrane, neuronal cell body, non-motile cilium, nucleus, plasma membrane, plasma membrane bounded cell projection, postsynaptic membrane, presynaptic membrane, synapse
Pathways: Alcoholism - Mus musculus (mouse), Amine ligand-binding receptors, Amphetamine addiction - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cocaine addiction - Mus musculus (mouse), Dopamine receptors, Dopaminergic synapse - Mus musculus (mouse), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Gap junction - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q61616
Entrez ID: 13488
|
Does Knockout of Itm2c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,685
|
Knockout
|
Itm2c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Itm2c (integral membrane protein 2C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of amyloid precursor protein biosynthetic process, negative regulation of neuron projection development, neuron differentiation, positive regulation of extrinsic apoptotic signaling pathway; MF: ATP binding, amyloid-beta binding; CC: Golgi apparatus, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q91VK4
Entrez ID: 64294
|
Does Knockout of Myef2 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Myef2
|
phagocytosis
|
macrophage
|
Gene: Myef2 (myelin basic protein expression factor 2, repressor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, mRNA binding, nucleic acid binding; CC: cytoplasm, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q8C854
Entrez ID: 17876
|
Does Knockout of Fnip1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Fnip1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fnip1 (folliculin interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, TORC1 signaling, cellular response to nutrient levels, cellular response to starvation, immature B cell differentiation, lysosome organization, negative regulation of TOR signaling, negative regulation of cell population proliferation, negative regulation of lysosome organization, negative regulation of protein localization to nucleus, negative regulation of transcription by RNA polymerase II, positive regulation of B cell apoptotic process, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of protein-containing complex assembly, protein destabilization, regulation of pro-B cell differentiation; MF: ATPase inhibitor activity, enzyme activator activity, enzyme binding, protein binding, protein-folding chaperone binding; CC: cytoplasm, cytosol, lysosomal membrane, lysosome, membrane
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q68FD7
Entrez ID: 216742
|
Does Knockout of C8a in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
C8a
|
protein/peptide accumulation
|
Mouse cell
|
Gene: C8a (complement component 8, alpha polypeptide)
Type: protein-coding
Summary: This gene encodes the alpha subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the alpha subunit, which associates with the beta and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the beta subunit. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: complement activation, complement activation, GZMK pathway, complement activation, alternative pathway, complement activation, classical pathway, immune response, immune system process, innate immune response, killing of cells of another organism, positive regulation of immune response; MF: complement binding, metal ion binding, protein-containing complex binding; CC: extracellular region, extracellular space, membrane, membrane attack complex, other organism cell membrane, plasma membrane, transmembrane transporter complex
Pathways: Amoebiasis - Mus musculus (mouse), Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Coronavirus disease - COVID-19 - Mus musculus (mouse), Immune System, Innate Immune System, Prion disease - Mus musculus (mouse), Regulation of Complement cascade, Systemic lupus erythematosus - Mus musculus (mouse), Terminal pathway of complement
UniProt: Q8K182
Entrez ID: 230558
|
Does Knockout of Gm38119 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Gm38119
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm38119 (predicted gene, 38119)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Serpinb6c in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Serpinb6c
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Serpinb6c (serine (or cysteine) peptidase inhibitor, clade B, member 6c)
Type: protein-coding
Summary: Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress; negative regulation of endopeptidase activity; and sensory perception of sound. Predicted to be part of serine protease inhibitor complex. Predicted to be active in cytoplasm and extracellular space. Is expressed in esophagus epithelium; ovary; ovary follicle; and testis. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cellular response to osmotic stress, sensory perception of sound; MF: peptidase inhibitor activity, protease binding, serine-type endopeptidase inhibitor activity; CC: cytoplasm, extracellular space, serine protease inhibitor complex
Pathways: Amoebiasis - Mus musculus (mouse)
UniProt: Q6P6K7, W4VSP4, A0A1Y7VLW2
Entrez ID: 97848
|
Does Knockout of Tbc1d12 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Tbc1d12
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tbc1d12 (TBC1D12: TBC1 domain family, member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of autophagosome assembly, vesicle-mediated transport; MF: GTPase activator activity, enzyme binding; CC: autophagosome, cytoplasmic vesicle, endosome, recycling endosome, vacuole
Pathways:
UniProt: Q6A039
Entrez ID: 209478
|
Does Knockout of Mapk4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Mapk4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mapk4 (mitogen-activated protein kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, intracellular signal transduction; MF: ATP binding, MAP kinase activity, kinase activity, nucleotide binding, protein heterodimerization activity, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nucleus
Pathways: IL-17 signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK6/MAPK4 signaling, Signal Transduction
UniProt: Q6P5G0
Entrez ID: 225724
|
Does Knockout of Fam124a in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Fam124a
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Fam124a (family with sequence similarity 124, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3Z5V4
Entrez ID: 629059
|
Does Knockout of Sema3e in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Sema3e
|
phagocytosis
|
macrophage
|
Gene: Sema3e (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, axon guidance, branching involved in blood vessel morphogenesis, cell differentiation, gonadotrophin-releasing hormone neuronal migration to the hypothalamus, negative chemotaxis, negative regulation of angiogenesis, negative regulation of cell-matrix adhesion, negative regulation of developmental process, negative regulation of multicellular organismal process, negative regulation of neuron apoptotic process, nervous system development, neural crest cell migration, positive regulation of cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of anatomical structure morphogenesis, regulation of cell shape, regulation of multicellular organismal development, semaphorin-plexin signaling pathway, sprouting angiogenesis, synapse organization; MF: chemorepellent activity, neuropilin binding, protein binding, receptor ligand activity, semaphorin receptor binding, signaling receptor binding; CC: extracellular region, extracellular space, plasma membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, Nervous system development, Other semaphorin interactions, Semaphorin interactions
UniProt: P70275
Entrez ID: 20349
|
Does Knockout of Mbd4 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Mbd4
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Mbd4 (methyl-CpG binding domain protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, intrinsic apoptotic signaling pathway in response to DNA damage, mitotic G2 DNA damage checkpoint signaling, response to radiation; MF: DNA binding, catalytic activity, hydrolase activity, pyrimidine-specific mismatch base pair DNA N-glycosylase activity; CC: chromatin, cytoplasm, nuclear speck, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Base-Excision Repair, AP Site Formation, Cleavage of the damaged pyrimidine , DNA Repair, Depyrimidination, Displacement of DNA glycosylase by APEX1, Resolution of Abasic Sites (AP sites)
UniProt: Q9Z2D7
Entrez ID: 17193
|
Does Knockout of Tbc1d1 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Tbc1d1
|
response to bacteria
|
renal medulla cell line
|
Gene: Tbc1d1 (TBC1 domain family, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of protein localization; MF: GTPase activator activity, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, nucleus
Pathways: AMPK signaling pathway - Mus musculus (mouse)
UniProt: Q60949
Entrez ID: 57915
|
Does Knockout of Hes2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Hes2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hes2 (hes family bHLH transcription factor 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the mammalian Hes gene family, the mammalian homologues of Drosophila hairy and Enhancer of split. Hes 2 is a basic helix-loop-helix transcriptional repressor and is an effector of the Notch signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: anterior/posterior pattern specification, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neurogenesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways: Human papillomavirus infection - Mus musculus (mouse)
UniProt: O54792
Entrez ID: 15206
|
Does Knockout of Adgra3 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Adgra3
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Adgra3 (adhesion G protein-coupled receptor A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, transmembrane signaling receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q7TT36
Entrez ID: 70693
|
Does Knockout of Tcf12 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Tcf12
|
cell cycle progression
|
breast epithelium
|
Gene: Tcf12 (transcription factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, nervous system development, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, response to gonadotropin-releasing hormone; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, E-box binding, HMG box domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SMAD binding, bHLH transcription factor binding, cAMP response element binding, protein binding, protein dimerization activity, protein heterodimerization activity, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, nuclear speck, nucleoplasm, nucleus, transcription regulator complex
Pathways: Developmental Biology, Gene expression (Transcription), Generic Transcription Pathway, Myogenesis, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Transcriptional regulation by RUNX1
UniProt: Q61286
Entrez ID: 21406
|
Does Knockout of Stat1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Stat1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Stat1 (signal transducer and activator of transcription 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, blood circulation, cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, cellular response to cytokine stimulus, cellular response to interferon-beta, cellular response to lipopolysaccharide, cellular response to type II interferon, cytokine-mediated signaling pathway, defense response, defense response to virus, interleukin-27-mediated signaling pathway, interleukin-7-mediated signaling pathway, interleukin-9-mediated signaling pathway, lipopolysaccharide-mediated signaling pathway, metanephric mesenchymal cell differentiation, metanephric mesenchymal cell proliferation involved in metanephros development, negative regulation by virus of viral protein levels in host cell, negative regulation of angiogenesis, negative regulation of canonical NF-kappaB signal transduction, negative regulation of developmental process, negative regulation of endothelial cell proliferation, negative regulation of macrophage fusion, negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, negative regulation of metanephric nephron tubule epithelial cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of defense response to virus by host, positive regulation of erythrocyte differentiation, positive regulation of interferon-alpha production, positive regulation of mesenchymal cell proliferation, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, renal tubule development, response to bacterium, response to cAMP, response to cytokine, response to exogenous dsRNA, response to interferon-beta, response to lipopolysaccharide, response to peptide hormone, response to type I interferon, response to type II interferon, signal transduction, tumor necrosis factor-mediated signaling pathway, type I interferon-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: CCR5 chemokine receptor binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, enzyme binding, histone acetyltransferase binding, histone binding, identical protein binding, promoter-specific chromatin binding, protein binding, protein homodimerization activity, protein phosphatase 2A binding, sequence-specific DNA binding, transcription coactivator binding, transcription corepressor binding, tumor necrosis factor receptor binding, ubiquitin-like protein ligase binding; CC: ISGF3 complex, RNA polymerase II transcription regulator complex, axon, chromatin, cytoplasm, cytosol, dendrite, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q8C3V4, Q99K94, Q8CFQ1, Q8C8M3, Q8C497, A0A087WSP5, A0A087WRI1, A0A087WSQ5
Entrez ID: 20846
|
Does Knockout of Hif1an in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Hif1an
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Hif1an (hypoxia-inducible factor 1, alpha subunit inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of Notch signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of myoblast differentiation, regulation of developmental process, regulation of signal transduction, regulation of vascular endothelial growth factor receptor signaling pathway; MF: NF-kappaB binding, Notch binding, RNA polymerase II-specific DNA-binding transcription factor binding, [protein]-asparagine 3-dioxygenase activity, ankyrin repeat binding, carboxylic acid binding, dioxygenase activity, ferrous iron binding, metal ion binding, oxidoreductase activity, peptidyl-aspartic acid 3-dioxygenase activity, peptidyl-histidine dioxygenase activity, protein binding, protein homodimerization activity, transcription corepressor activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress
UniProt: Q8BLR9
Entrez ID: 319594
|
Does Knockout of Cyp4a30b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Cyp4a30b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cyp4a30b (cytochrome P450, family 4, subfamily a, polypeptide 30b)
Type: protein-coding
Summary: Predicted to enable 16-hydroxypalmitate dehydrogenase activity and monooxygenase activity. Predicted to be involved in fatty acid metabolic process; icosanoid biosynthetic process; and kidney development. Predicted to be located in apical plasma membrane; cytoplasm; and extracellular space. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: arachidonate metabolic process, fatty acid metabolic process, icosanoid biosynthetic process, kidney development, lauric acid metabolic process, linoleic acid metabolic process; MF: 16-hydroxypalmitate dehydrogenase activity, alkane 1-monooxygenase activity, arachidonate epoxygenase activity, arachidonate monooxygenase activity, heme binding, iron ion binding, leukotriene-B4 20-monooxygenase activity, long-chain fatty acid omega-hydroxylase activity, medium-chain fatty acid omega-hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; CC: apical plasma membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular space, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Fatty acids, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Metabolism, Metabolism of lipids, Miscellaneous substrates, PPAR signaling pathway - Mus musculus (mouse), Phase I - Functionalization of compounds, Retinol metabolism - Mus musculus (mouse), Synthesis of Leukotrienes (LT) and Eoxins (EX), Vascular smooth muscle contraction - Mus musculus (mouse)
UniProt: A0A087WS15
Entrez ID: 435802
|
Does Knockout of Pkia in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Pkia
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Pkia (protein kinase inhibitor, alpha)
Type: protein-coding
Summary: Enables cAMP-dependent protein kinase inhibitor activity and protein kinase A catalytic subunit binding activity. Acts upstream of or within negative regulation of macromolecule metabolic process; negative regulation of protein import into nucleus; and regulation of G2/M transition of mitotic cell cycle. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PKIA (cAMP-dependent protein kinase inhibitor alpha). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of cAMP/PKA signal transduction, negative regulation of protein import into nucleus, negative regulation of transcription by RNA polymerase II, regulation of G2/M transition of mitotic cell cycle; MF: cAMP-dependent protein kinase inhibitor activity, protein binding, protein kinase A catalytic subunit binding, protein kinase inhibitor activity; CC: cytoplasm, nucleus
Pathways: Alcoholism - Mus musculus (mouse)
UniProt: P63248
Entrez ID: 18767
|
Does Knockout of Trpv6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Trpv6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trpv6 (transient receptor potential cation channel, subfamily V, member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion homeostasis, calcium ion import, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, parathyroid hormone secretion, protein homotetramerization, response to calcium ion, transmembrane transport; MF: calcium channel activity, calmodulin binding, identical protein binding, metal ion binding, monoatomic ion channel activity, protein binding; CC: calcium channel complex, membrane, plasma membrane
Pathways: Ion channel transport, Mineral absorption - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q91WD2
Entrez ID: 64177
|
Does Knockout of Fan1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Fan1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Fan1 (FANCD2/FANCI-associated nuclease 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via homologous recombination, interstrand cross-link repair, nucleotide-excision repair; MF: 5'-3' exonuclease activity, 5'-flap endonuclease activity, DNA binding, endonuclease activity, exonuclease activity, flap-structured DNA binding, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding, nuclease activity, nucleic acid binding, phosphodiesterase I activity, ubiquitin-modified protein reader activity, zinc ion binding; CC: cilium, cytosol, intercellular bridge, nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse)
UniProt: Q69ZT1
Entrez ID: 330554
|
Does Knockout of Cdh4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Cdh4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cdh4 (cadherin 4)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. The encoded protein is involved in retinal angiogenesis during development where it plays a crucial role in the endothelial-astrocyte interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: adherens junction organization, axon guidance, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, positive regulation of axon extension; MF: beta-catenin binding, cadherin binding, calcium ion binding, metal ion binding; CC: adherens junction, catenin complex, membrane, plasma membrane
Pathways: Adherens junctions interactions, Cell adhesion molecules - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Developmental Biology, Myogenesis
UniProt: P39038
Entrez ID: 12561
|
Does Knockout of Ccdc47 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Ccdc47
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccdc47 (coiled-coil domain containing 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ER overload response, ERAD pathway, calcium ion homeostasis, endoplasmic reticulum calcium ion homeostasis, endoplasmic reticulum organization, multi-pass transmembrane protein insertion into ER membrane, post-embryonic development, protein folding, protein insertion into ER membrane; MF: calcium ion binding, protein binding, protein folding chaperone, ribosome binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, multi-pass translocon complex, protein folding chaperone complex, rough endoplasmic reticulum, rough endoplasmic reticulum membrane
Pathways:
UniProt: Q9D024
Entrez ID: 67163
|
Does Knockout of Dgkz in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Dgkz
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Dgkz (diacylglycerol kinase zeta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, diacylglycerol metabolic process, glycerolipid metabolic process, intracellular signal transduction, lipid metabolic process, lipid phosphorylation, maintenance of postsynaptic density structure, mitotic G1 DNA damage checkpoint signaling, negative regulation of Ras protein signal transduction, negative regulation of T cell receptor signaling pathway, phosphatidic acid biosynthetic process, phospholipase C-activating G protein-coupled receptor signaling pathway, regulation of Ras protein signal transduction, signal transduction; MF: ATP binding, ATP-dependent diacylglycerol kinase activity, alkylglycerol kinase activity, enzyme inhibitor activity, kinase activity, lipid kinase activity, metal ion binding, nucleotide binding, protein binding, transferase activity, zinc ion binding; CC: Schaffer collateral - CA1 synapse, cell projection, cytoplasm, cytosol, glutamatergic synapse, lamellipodium, membrane, nuclear speck, nucleus, plasma membrane, postsynaptic density
Pathways: Choline metabolism in cancer - Mus musculus (mouse), Effects of PIP2 hydrolysis, G alpha (q) signalling events, GPCR downstream signalling, Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid metabolism - Mus musculus (mouse), Hemostasis, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation, signaling and aggregation, Signal Transduction, Signaling by GPCR
UniProt: Q80UP3
Entrez ID: 104418
|
Does Knockout of Plagl2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Plagl2
|
cell proliferation
|
Regulatory T cell
|
Gene: Plagl2 (pleiomorphic adenoma gene-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chylomicron assembly, lipid metabolic process, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of transcription by RNA polymerase II, post-embryonic development, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q925T4
Entrez ID: 54711
|
Does Knockout of Ust in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Ust
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ust (uronyl-2-sulfotransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dermatan sulfate proteoglycan biosynthetic process, establishment of cell polarity, regulation of axonogenesis; MF: 3'-phosphoadenosine 5'-phosphosulfate binding, chondroitin 2-sulfotransferase activity, dermatan 2-sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: CS-GAG biosynthesis, Chondroitin sulfate/dermatan sulfate metabolism, DS-GAG biosynthesis, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q8BUB6
Entrez ID: 338362
|
Does Knockout of Gprin3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Gprin3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gprin3 (GPRIN family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell morphogenesis involved in neuron differentiation, excitatory chemical synaptic transmission, locomotory behavior, neuron projection development, neuronal action potential, response to cocaine, vitamin D receptor signaling pathway; CC: plasma membrane, synapse
Pathways:
UniProt: Q8BWS5
Entrez ID: 243385
|
Does Knockout of Utf1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Utf1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Utf1 (undifferentiated embryonic cell transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II; MF: HMG box domain binding, TBP-class protein binding, protein binding, transcription coactivator activity; CC: nucleus
Pathways:
UniProt: Q6J1H4
Entrez ID: 22286
|
Does Knockout of Bhlha15 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Bhlha15
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Bhlha15 (basic helix-loop-helix family, member a15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Golgi organization, axon development, calcium-mediated signaling, cell differentiation, cell-cell adhesion mediated by cadherin, cell-cell junction organization, cell-cell signaling, cellular response to glucose starvation, endoplasmic reticulum unfolded protein response, establishment of localization in cell, glandular epithelial cell maturation, glucose homeostasis, intracellular distribution of mitochondria, localization of cell, mitochondrial calcium ion transmembrane transport, negative regulation of myotube differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, sensory organ development, type B pancreatic cell maturation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, identical protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways: Maturity onset diabetes of the young - Mus musculus (mouse)
UniProt: Q9QYC3
Entrez ID: 17341
|
Does Knockout of Hace1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Hace1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Hace1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, membrane fusion, protein K48-linked ubiquitination, protein ubiquitination, regulation of cell migration, ubiquitin-dependent protein catabolic process; MF: small GTPase binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, cytoplasm, endoplasmic reticulum, membrane, nuclear body, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q3U0D9
Entrez ID: 209462
|
Does Knockout of Dcps in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Dcps
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dcps (decapping enzyme, scavenger)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA cis splicing, via spliceosome, mRNA methylguanosine-cap decapping, mRNA processing, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; MF: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity, RNA 7-methylguanosine cap binding, hydrolase activity, identical protein binding; CC: P-body, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Mus musculus (mouse), mRNA decay by 3' to 5' exoribonuclease
UniProt: Q9DAR7
Entrez ID: 69305
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Does Knockout of Cetn4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
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Knockout
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Cetn4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cetn4 (centrin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, microtubule cytoskeleton organization; MF: G-protein beta/gamma-subunit complex binding, calcium ion binding, heterotrimeric G-protein binding, metal ion binding; CC: centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule organizing center, nucleus
Pathways:
UniProt: Q8K4K1
Entrez ID: 207175
|
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