prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Fam76b in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Fam76b
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Fam76b (family with sequence similarity 76, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA stabilization, negative regulation of inflammatory response, negative regulation of macrophage activation, negative regulation of protein export from nucleus; CC: nuclear speck, nucleus
Pathways:
UniProt: Q80XP8
Entrez ID: 72826
|
Does Knockout of Casr in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Casr
|
cell proliferation
|
Regulatory T cell
|
Gene: Casr (calcium-sensing receptor)
Type: protein-coding
Summary: Predicted to enable several functions, including integrin binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Involved in regulation of presynaptic membrane potential. Acts upstream of or within positive regulation of ATP-dependent activity; positive regulation of gene expression; and regulation of calcium ion transport. Is active in glutamatergic synapse. Is expressed in several structures, including branchial pouch; central nervous system; lung; metanephros; and superior cervical ganglion. Used to study autosomal dominant hypocalcemia 1; familial hypocalciuric hypercalcemia 1; and hyperparathyroidism. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); intellectual disability; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, JNK cascade, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, bile acid secretion, branching morphogenesis of an epithelial tube, cellular response to glucose stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to hypoxia, cellular response to low-density lipoprotein particle stimulus, cellular response to peptide, cellular response to vitamin D, chloride transmembrane transport, detection of calcium ion, establishment of localization in cell, fat pad development, intracellular calcium ion homeostasis, ossification, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of calcium ion import, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of insulin secretion, positive regulation of positive chemotaxis, positive regulation of vasoconstriction, regulation of calcium ion transport, regulation of presynaptic membrane potential, response to calcium ion, response to fibroblast growth factor, response to ischemia, response to metal ion, signal transduction, vasodilation; MF: G protein-coupled receptor activity, amino acid binding, calcium ion binding, identical protein binding, integrin binding, metal ion binding, protein homodimerization activity, protein kinase binding, transmembrane transporter binding; CC: apical plasma membrane, axon, axon terminus, basolateral plasma membrane, cell surface, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, presynaptic membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, NOD-like receptor signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q9QY96
Entrez ID: 12374
|
Does Knockout of Phactr3 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Phactr3
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Phactr3 (phosphatase and actin regulator 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: actin binding, protein phosphatase inhibitor activity; CC: nuclear matrix, nucleoplasm, nucleus
Pathways:
UniProt: Q8BYK5
Entrez ID: 74189
|
Does Knockout of Nxph2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Nxph2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Nxph2 (neurexophilin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: signaling receptor binding
Pathways:
UniProt: Q61199
Entrez ID: 18232
|
Does Knockout of Bet1l in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Bet1l
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bet1l (Bet1 golgi vesicular membrane trafficking protein like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: membrane fusion, protein transport, regulation of retrograde vesicle-mediated transport, Golgi to ER, retrograde transport, endosome to Golgi; MF: SNAP receptor activity; CC: Golgi apparatus, Golgi membrane, Golgi stack, Golgi-associated vesicle, SNARE complex, cytosol, endosome, membrane, trans-Golgi network
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O35153
Entrez ID: 54399
|
Does Knockout of Rgl3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Rgl3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rgl3 (ral guanine nucleotide dissociation stimulator-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, signal transduction, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Signal Transduction
UniProt: Q3UYI5
Entrez ID: 71746
|
Does Knockout of Pglyrp4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Pglyrp4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pglyrp4 (peptidoglycan recognition protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, biological process involved in interaction with host, defense response to Gram-positive bacterium, defense response to bacterium, detection of bacterium, immune response, immune system process, innate immune response, killing of cells of another organism, negative regulation of natural killer cell differentiation involved in immune response, negative regulation of type II interferon production, peptidoglycan catabolic process; MF: N-acetylmuramoyl-L-alanine amidase activity, peptidoglycan binding, peptidoglycan immune receptor activity, protein heterodimerization activity, zinc ion binding; CC: extracellular region, protein-containing complex
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: Q0VB07
Entrez ID: 384997
|
Does Knockout of Tagln2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Tagln2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tagln2 (transgelin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, epithelial cell differentiation
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q9WVA4
Entrez ID: 21346
|
Does Knockout of Bsnd in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Bsnd
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Bsnd (barttin CLCNK type accessory beta subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, chloride transport, intracellular chloride ion homeostasis, intracellular monoatomic ion homeostasis, intracellular potassium ion homeostasis, sensory perception of sound; MF: chloride channel activity, chloride channel regulator activity, protein binding; CC: basolateral plasma membrane, membrane, plasma membrane, protein-containing complex
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q8VIM4
Entrez ID: 140475
|
Does Knockout of Arhgef1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Arhgef1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Arhgef1 (Rho guanine nucleotide exchange factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho-activating G protein-coupled receptor signaling pathway, microtubule depolymerization; MF: G protein-coupled receptor binding, GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding; CC: cytoplasm, cytosol, membrane, plasma membrane
Pathways: Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, Human cytomegalovirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), NRAGE signals death through JNK, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vascular smooth muscle contraction - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: Q61210
Entrez ID: 16801
|
Does Knockout of Hspa4l in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Hspa4l
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hspa4l (heat shock protein 4 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein folding, response to unfolded protein; MF: ATP binding, ATP-dependent protein folding chaperone, adenyl-nucleotide exchange factor activity, nucleotide binding, protein binding; CC: cytoplasm, cytosol, nucleus
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of HSF1-mediated heat shock response
UniProt: P48722
Entrez ID: 18415
|
Does Knockout of Cyb5r2 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,411
|
Knockout
|
Cyb5r2
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Cyb5r2 (cytochrome b5 reductase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: FAD binding, cytochrome-b5 reductase activity, acting on NAD(P)H, oxidoreductase activity; CC: endoplasmic reticulum membrane, membrane, mitochondrion
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Erythrocytes take up carbon dioxide and release oxygen, O2/CO2 exchange in erythrocytes, Transport of small molecules
UniProt: Q3KNK3
Entrez ID: 320635
|
Does Knockout of Adam28 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Adam28
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Adam28 (a disintegrin and metallopeptidase domain 28)
Type: protein-coding
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are typically membrane-anchored, although a form of this protein may be secreted. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein may bind to integrins and regulate lymphocyte migration by enhancing cell adhesion. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: proteolysis; MF: hydrolase activity, immunoglobulin receptor binding, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity; CC: cell surface, membrane, mitochondrion, plasma membrane
Pathways:
UniProt: Q9JLN6
Entrez ID: 13522
|
Does Knockout of Rsbn1l in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Rsbn1l
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rsbn1l (round spermatid basic protein 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: dioxygenase activity, metal ion binding, molecular_function, oxidoreductase activity; CC: nucleus
Pathways:
UniProt: A0A0G2JDQ6, D3Z0K6, A0A0G2JEI9
Entrez ID: 242860
|
Does Knockout of Hoxb4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Hoxb4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hoxb4 (homeobox B4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, bone marrow development, definitive hemopoiesis, embryonic organ morphogenesis, embryonic skeletal system morphogenesis, hematopoietic stem cell differentiation, hematopoietic stem cell proliferation, hemopoiesis, morphogenesis of an epithelial sheet, negative regulation of transcription by RNA polymerase II, positive regulation of stem cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, skeletal system development, skeletal system morphogenesis, somatic stem cell division, spleen development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: centrosome, nucleoplasm, nucleus
Pathways:
UniProt: P10284
Entrez ID: 15412
|
Does Knockout of Magt1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Magt1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Magt1 (magnesium transporter 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cognition, magnesium ion transmembrane transport, magnesium ion transport, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex B, plasma membrane
Pathways: Adaptive Immune System, Co-inhibition by PD-1, Immune System, Innate Immune System, Miscellaneous transport and binding events, Neutrophil degranulation, PD-L1(CD274) glycosylation and translocation to plasma membrane, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Transport of small molecules
UniProt: Q9CQY5
Entrez ID: 67075
|
Does Knockout of Gm527 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Gm527
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm527 (predicted gene 527)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled dopamine receptor signaling pathway, NMDA selective glutamate receptor signaling pathway, biological_process, cAMP-mediated signaling, gene expression, memory, neurogenesis
Pathways:
UniProt: Q4KL13
Entrez ID: 217648
|
Does Knockout of Phyhipl in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Phyhipl
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Phyhipl (phytanoyl-CoA hydroxylase interacting protein-like)
Type: protein-coding
Summary: Located in mitochondrion. Is expressed in several structures, including nervous system; neural retina; and olfactory epithelium. Orthologous to human PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cytoplasm, mitochondrion
Pathways:
UniProt: Q8BGT8
Entrez ID: 70911
|
Does Knockout of Kdm4c in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Kdm4c
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kdm4c (lysine (K)-specific demethylase 4C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: androgen receptor signaling pathway, blastocyst formation, chromatin organization, chromatin remodeling, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulation of stem cell differentiation, stem cell population maintenance; MF: chromatin binding, dioxygenase activity, enzyme binding, histone H3K36 demethylase activity, histone H3K9 demethylase activity, histone H3K9me2/H3K9me3 demethylase activity, histone demethylase activity, metal ion binding, nuclear androgen receptor binding, oxidoreductase activity, transcription coactivator activity, zinc ion binding; CC: chromatin, nucleus, pericentric heterochromatin
Pathways: Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones
UniProt: Q8VCD7
Entrez ID: 76804
|
Does Knockout of Vps18 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Vps18
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Vps18 (VPS18 CORVET/HOPS core subunit)
Type: protein-coding
Summary: Enables actin binding activity. Acts upstream of or within endosome organization and symbiont entry into host cell. Located in actin filament and early endosome. Part of AP-3 adaptor complex and CORVET complex. Is expressed in alimentary system; ganglia; nose; and peripheral nervous system. Orthologous to human VPS18 (VPS18 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: autophagy, endosome organization, endosome to lysosome transport, intracellular protein transport, lysosome organization, negative regulation of intracellular estrogen receptor signaling pathway, organelle fusion, protein transport, protein ubiquitination, regulation of synaptic vesicle exocytosis, symbiont entry into host cell, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: actin binding, metal ion binding, protein binding, protein-macromolecule adaptor activity, syntaxin binding, ubiquitin protein ligase activity, zinc ion binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endomembrane system, endosome, glutamatergic synapse, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, presynapse
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q8R307
Entrez ID: 228545
|
Does Knockout of Fap in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Fap
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fap (fibroblast activation protein)
Type: protein-coding
Summary: This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: angiogenesis, apoptotic process, cell adhesion, endothelial cell migration, melanocyte apoptotic process, melanocyte proliferation, negative regulation of cell proliferation involved in contact inhibition, negative regulation of extracellular matrix disassembly, negative regulation of extracellular matrix organization, positive regulation of execution phase of apoptosis, proteolysis, proteolysis involved in protein catabolic process, regulation of cell cycle, regulation of collagen catabolic process; MF: dipeptidyl-peptidase activity, endopeptidase activity, hydrolase activity, identical protein binding, integrin binding, peptidase activity, protease binding, protein homodimerization activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: anchoring junction, apical part of cell, basal part of cell, cell projection, cell surface, extracellular region, extracellular space, lamellipodium, lamellipodium membrane, membrane, peptidase complex, plasma membrane, ruffle membrane
Pathways:
UniProt: P97321
Entrez ID: 14089
|
Does Knockout of Ggct in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 2,187
|
Knockout
|
Ggct
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Ggct (gamma-glutamyl cyclotransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: release of cytochrome c from mitochondria; MF: gamma-glutamylcyclotransferase activity, lyase activity, protein homodimerization activity; CC: cytosol
Pathways: γ-glutamyl cycle, Biological oxidations, Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Glutathione synthesis and recycling, Metabolism, Phase II - Conjugation of compounds
UniProt: Q9D7X8
Entrez ID: 110175
|
Does Knockout of Parm1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Parm1
|
cell cycle progression
|
breast epithelium
|
Gene: Parm1 (prostate androgen-regulated mucin-like protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, Golgi membrane, cytosol, early endosome, endosome, endosome membrane, late endosome, membrane, nucleoplasm, plasma membrane
Pathways:
UniProt: Q923D3
Entrez ID: 231440
|
Does Knockout of Slc44a3 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Slc44a3
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Slc44a3 (solute carrier family 44, member 3)
Type: protein-coding
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in gut and olfactory epithelium. Orthologous to human SLC44A3 (solute carrier family 44 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: organic cation transport, transmembrane transport; MF: organic cation transmembrane transporter activity, transmembrane transporter activity; CC: membrane
Pathways: Choline metabolism in cancer - Mus musculus (mouse), Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, SLC-mediated bile acid transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Synthesis of PC, Transport of small molecules
UniProt: Q921V7
Entrez ID: 213603
|
Does Knockout of Gpr149 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Gpr149
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Gpr149 (G protein-coupled receptor 149)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, antral ovarian follicle growth, negative regulation of ovulation, neuropeptide signaling pathway, preantral ovarian follicle growth, signal transduction; MF: G protein-coupled receptor activity, neuropeptide binding; CC: membrane, neuron projection, plasma membrane
Pathways:
UniProt: Q3UVY1
Entrez ID: 229357
|
Does Knockout of Vps45 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Vps45
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Vps45 (vacuolar protein sorting 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, protein transport, vesicle-mediated transport; CC: Golgi apparatus, Golgi membrane, cytoplasmic vesicle, endosome, endosome membrane, membrane, synaptic vesicle
Pathways: Endocytosis - Mus musculus (mouse), Factors involved in megakaryocyte development and platelet production, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Vesicle-mediated transport
UniProt: P97390
Entrez ID: 22365
|
Does Knockout of Pam in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Pam
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pam (peptidylglycine alpha-amidating monooxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, fatty acid primary amide biosynthetic process, lipid metabolic process, long-chain fatty acid metabolic process, peptide amidation, peptide metabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of actin cytoskeleton organization, regulation of transcription by RNA polymerase II, response to pH, response to xenobiotic stimulus, response to zinc ion, toxin metabolic process; MF: L-ascorbic acid binding, calcium ion binding, catalytic activity, copper ion binding, identical protein binding, lyase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen, peptidylamidoglycolate lyase activity, peptidylglycine monooxygenase activity, protein kinase binding, zinc ion binding; CC: cell surface, cytoplasmic vesicle, cytosol, extracellular region, extracellular space, membrane, neuronal cell body, perikaryon, perinuclear region of cytoplasm, plasma membrane, secretory granule, secretory granule membrane, trans-Golgi network, transport vesicle membrane
Pathways:
UniProt: P97467
Entrez ID: 18484
|
Does Knockout of BC051665 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
BC051665
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: BC051665 (cDNA sequence BC051665)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen catabolic process, fusion of virus membrane with host endosome membrane, fusion of virus membrane with host plasma membrane, protein autoprocessing, proteolysis, proteolysis involved in protein catabolic process, receptor-mediated endocytosis of virus by host cell, symbiont entry into host cell, zymogen activation; MF: collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, fibronectin binding, histone binding, hydrolase activity, peptidase activity, proteoglycan binding, serpin family protein binding; CC: Golgi apparatus, extracellular space, lysosome, multivesicular body, plasma membrane
Pathways: Adaptive Immune System, Adherens junctions interactions, Assembly of collagen fibrils and other multimeric structures, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Collagen degradation, Collagen formation, Degradation of CDH1, Degradation of the extracellular matrix, Extracellular matrix organization, Gene expression (Transcription), Generic Transcription Pathway, Glycosaminoglycan metabolism, HS-GAG degradation, Heparan sulfate/heparin (HS-GAG) metabolism, Immune System, Innate Immune System, MHC class II antigen presentation, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of keratinocytes, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Toll-like Receptor Cascades, Trafficking and processing of endosomal TLR, Transcriptional regulation by RUNX1
UniProt: Q80X23, E9Q623, Q3ULD9
Entrez ID: 218275
|
Does Knockout of Nfu1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Nfu1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nfu1 (NFU1 iron-sulfur cluster scaffold)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, iron ion binding, iron-sulfur cluster binding, metal ion binding, protein binding; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, Protein lipoylation
UniProt: Q9QZ23
Entrez ID: 56748
|
Does Knockout of Prok2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Prok2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prok2 (prokineticin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, chemotaxis, circadian rhythm, coronary vasculature development, endothelial cell proliferation, epicardium-derived cardiac endothelial cell differentiation, epicardium-derived cardiac vascular smooth muscle cell differentiation, negative regulation of apoptotic process, neuropeptide signaling pathway, positive regulation of smooth muscle contraction, rhythmic process, spermatogenesis, vasculogenesis involved in coronary vascular morphogenesis; MF: G protein-coupled receptor binding
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9QXU7
Entrez ID: 50501
|
Does Knockout of Jph2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Jph2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Jph2 (junctophilin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion homeostasis, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of cytosolic calcium ion concentration, regulation of cardiac muscle tissue development; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, core promoter sequence-specific DNA binding, phosphatidic acid binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding, phosphatidylserine binding, protein binding; CC: Z disc, endoplasmic reticulum, endoplasmic reticulum membrane, junctional membrane complex, membrane, nucleus, plasma membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways:
UniProt: Q9ET78
Entrez ID: 59091
|
Does Knockout of Csdc2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Csdc2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Csdc2 (cold shock domain containing C2, RNA binding)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA processing, regulation of mRNA stability; MF: RNA binding, mRNA 3'-UTR binding, nucleic acid binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q91YQ3
Entrez ID: 105859
|
Does Knockout of H60c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,685
|
Knockout
|
H60c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: H60c (histocompatibility 60c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, immune response, immune system process, natural killer cell mediated cytotoxicity, positive regulation of T cell mediated cytotoxicity; MF: natural killer cell lectin-like receptor binding; CC: external side of plasma membrane, extracellular space, membrane, plasma membrane, side of membrane
Pathways:
UniProt: B1B213
Entrez ID: 670558
|
Does Knockout of Gm17455 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Gm17455
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Gm17455 (predicted gene, 17455)
Type: protein-coding
Summary: Orthologous to human C10orf105 (chromosome 10 open reading frame 105). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A0A3B2WBH3, G3UW87, A0A3B2WAM3
Entrez ID: 100302688
|
Does Knockout of Sptan1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Sptan1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sptan1 (spectrin alpha, non-erythrocytic 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament capping; MF: actin binding, actin filament binding, calcium ion binding, calmodulin binding, metal ion binding, protein binding, protein-containing complex binding, spectrin binding; CC: Z disc, cell cortex, cell junction, cell projection, cortical actin cytoskeleton, cortical cytoskeleton, cuticular plate, cytoplasm, cytoskeleton, cytosol, fascia adherens, glutamatergic synapse, lateral plasma membrane, membrane, microtubule cytoskeleton, myelin sheath, paranodal junction, paranode region of axon, plasma membrane, postsynapse, protein-containing complex
Pathways: Apoptosis, Apoptosis - Mus musculus (mouse), Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Asparagine N-linked glycosylation, Axon guidance, COPI-mediated anterograde transport, Caspase-mediated cleavage of cytoskeletal proteins, Developmental Biology, ER to Golgi Anterograde Transport, Immune System, Innate Immune System, Interaction between L1 and Ankyrins, L1CAM interactions, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Membrane Trafficking, Metabolism of proteins, NCAM signaling for neurite out-growth, Nervous system development, Neutrophil degranulation, Post-translational protein modification, Programmed Cell Death, RAF/MAP kinase cascade, RHO GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P16546
Entrez ID: 20740
|
Does Knockout of Dyrk3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Dyrk3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dyrk3 (dual-specificity tyrosine phosphorylation regulated kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, erythrocyte differentiation, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of apoptotic process, nuclear speck organization, organelle disassembly, positive regulation of cell cycle G2/M phase transition, protein phosphorylation, regulation of TORC1 signaling, regulation of cellular response to stress, stress granule disassembly; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: centrosome, cytoplasm, cytoplasmic stress granule, cytoskeleton, cytosol, nuclear speck, nucleoplasm, nucleus, pericentriolar material
Pathways:
UniProt: Q922Y0
Entrez ID: 226419
|
Does Knockout of Fars2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Fars2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fars2 (phenylalanine-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phenylalanyl-tRNA aminoacylation, tRNA aminoacylation, tRNA processing, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, phenylalanine-tRNA ligase activity, tRNA binding; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q99M01
Entrez ID: 69955
|
Does Knockout of Gpr45 in Microglial Cell Line causally result in phagocytosis?
| 0
| 1,587
|
Knockout
|
Gpr45
|
phagocytosis
|
Microglial Cell Line
|
Gene: Gpr45 (G protein-coupled receptor 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways: G alpha (s) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q9EQQ4
Entrez ID: 93690
|
Does Knockout of Ifit1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Ifit1
|
response to virus
|
Microglial Cell Line
|
Gene: Ifit1 (interferon-induced protein with tetratricopeptide repeats 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interferon-alpha, cellular response to interferon-beta, defense response to virus, immune system process, innate immune response, negative regulation of viral translation, response to bacterium, response to virus; MF: RNA binding, RNA sequestering activity, enzyme inhibitor activity, protein binding; CC: cytoplasm, cytosol
Pathways: Hepatitis C - Mus musculus (mouse)
UniProt: Q64282
Entrez ID: 15957
|
Does Knockout of Rnf20 in Lung Cancer Cell Line causally result in tumorigenicity?
| 0
| 1,781
|
Knockout
|
Rnf20
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Rnf20 (ring finger protein 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of cell migration, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, protein polyubiquitination, protein ubiquitination, regulation of DNA-templated transcription, ubiquitin-dependent protein catabolic process; MF: chromatin binding, histone H2B C-terminal K residue ubiquitin ligase activity, histone binding, identical protein binding, mRNA 3'-UTR binding, metal ion binding, p53 binding, protein binding, transcription coactivator activity, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: HULC complex, nucleolus, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q5DTM8
Entrez ID: 109331
|
Does Knockout of Slco4c1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Slco4c1
|
phagocytosis
|
macrophage
|
Gene: Slco4c1 (solute carrier organic anion transporter family, member 4C1)
Type: protein-coding
Summary: Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including forebrain; genitourinary system; integumental system; respiratory system; and sensory organ. Orthologous to human SLCO4C1 (solute carrier organic anion transporter family member 4C1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell differentiation, monoatomic ion transport, organic anion transport, sodium-independent organic anion transport, spermatogenesis, transmembrane transport; MF: organic anion transmembrane transporter activity, sodium-independent organic anion transmembrane transporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, Organic anion transport by SLCO transporters, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: Q8BGD4
Entrez ID: 227394
|
Does Knockout of Srm in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Srm
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Srm (spermidine synthase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to leukemia inhibitory factor, polyamine biosynthetic process, polyamine metabolic process, spermidine biosynthetic process; MF: catalytic activity, identical protein binding, protein homodimerization activity, spermidine synthase activity, transferase activity
Pathways: Arginine and proline metabolism - Mus musculus (mouse), Cysteine and methionine metabolism - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, spermidine biosynthesis I, spermine biosynthesis II
UniProt: Q64674
Entrez ID: 20810
|
Does Knockout of Slc6a3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Slc6a3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc6a3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenohypophysis development, amino acid transport, cognition, dopamine biosynthetic process, dopamine catabolic process, dopamine transport, dopamine uptake, hyaloid vascular plexus regression, lactation, locomotory behavior, monoamine transport, neurotransmitter transport, neurotransmitter uptake, norepinephrine uptake, positive regulation of multicellular organism growth, prepulse inhibition, regulation of dopamine metabolic process, response to cAMP, response to cocaine, response to ethanol, response to iron ion, response to nicotine, response to xenobiotic stimulus, sensory perception of smell, sodium ion transmembrane transport; MF: amine binding, dopamine binding, dopamine:sodium symporter activity, heterocyclic compound binding, metal ion binding, monoamine transmembrane transporter activity, neurotransmitter transmembrane transporter activity, norepinephrine:sodium symporter activity, protease binding, protein binding, protein phosphatase 2A binding, protein-containing complex binding, signaling receptor binding, symporter activity; CC: axon, axon terminus, cell projection, cell surface, dopaminergic synapse, flotillin complex, membrane, membrane raft, neuron projection, neuronal cell body, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways: Alcoholism - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Dopamine clearance from the synaptic cleft, Dopaminergic synapse - Mus musculus (mouse), Neuronal System, Neurotransmitter clearance, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules
UniProt: Q61327
Entrez ID: 13162
|
Does Knockout of Dcun1d5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,683
|
Knockout
|
Dcun1d5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dcun1d5 (defective in cullin neddylation 1 domain containing 5)
Type: protein-coding
Summary: Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in several processes, including positive regulation of protein neddylation; protein neddylation; and regulation of cell growth. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; jaw; nervous system; and thymus primordium. Orthologous to human DCUN1D5 (defective in cullin neddylation 1 domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, positive regulation of protein neddylation, protein neddylation, regulation of cell growth, regulation of protein neddylation; MF: cullin family protein binding, ubiquitin conjugating enzyme binding, ubiquitin-like protein binding; CC: cytoplasm, cytoskeleton, nucleus, spindle, ubiquitin ligase complex
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9CXV9
Entrez ID: 76863
|
Does Knockout of Fgf21 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Fgf21
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Fgf21 (fibroblast growth factor 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fibroblast growth factor receptor signaling pathway, negative regulation of endothelial cell apoptotic process, neurogenesis, positive regulation of D-glucose import, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of triglyceride catabolic process, regulation of cell migration; MF: fibroblast growth factor receptor binding, growth factor activity; CC: cytoplasm, cytosol, extracellular region, extracellular space
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cellular hexose transport, Gastric cancer - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Melanoma - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), SLC-mediated transmembrane transport, Thermogenesis - Mus musculus (mouse), Transport of small molecules
UniProt: Q9JJN1
Entrez ID: 56636
|
Does Knockout of Rhox4f in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Rhox4f
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rhox4f (reproductive homeobox 4F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: Q2MDF8
Entrez ID: 636177
|
Does Knockout of Col5a1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Col5a1
|
cell proliferation
|
Regulatory T cell
|
Gene: Col5a1 (collagen, type V, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel development, cell adhesion, cell migration, collagen biosynthetic process, collagen fibril organization, eye morphogenesis, heart morphogenesis, integrin biosynthetic process, negative regulation of endodermal cell differentiation, skin development, supramolecular fiber organization, tendon development, wound healing, spreading of epidermal cells; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, heparin binding, platelet-derived growth factor binding, protein binding, proteoglycan binding; CC: basement membrane, collagen trimer, collagen type V trimer, collagen type XI trimer, extracellular matrix, extracellular region, extracellular space
Pathways: Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Developmental Biology, ECM proteoglycans, Extracellular matrix organization, Fibronectin matrix formation, Integrin cell surface interactions, MET activates PTK2 signaling, MET promotes cell motility, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Non-integrin membrane-ECM interactions, Protein digestion and absorption - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases
UniProt: O88207
Entrez ID: 12831
|
Does Knockout of Cilp2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Cilp2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cilp2 (cartilage intermediate layer protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, molecular_function; CC: extracellular region, extracellular space
Pathways:
UniProt: D3Z7H8
Entrez ID: 68709
|
Does Knockout of Spag6l in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Spag6l
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Spag6l (sperm associated antigen 6-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cell projection organization, cerebrospinal fluid circulation, ear development, epithelial cilium movement involved in extracellular fluid movement, establishment of epithelial cell apical/basal polarity, establishment of localization in cell, fibroblast migration, filopodium assembly, flagellated sperm motility, intracellular protein localization, motile cilium assembly, mucociliary clearance, neuron projection extension, non-motile cilium assembly, regulation of cilium beat frequency, regulation of establishment of planar polarity, sperm axoneme assembly, spermatogenesis, stress fiber assembly, substrate-dependent cell migration, cell attachment to substrate, ventricular system development; MF: microtubule binding, protein binding; CC: acrosomal vesicle, axonemal central apparatus, axoneme, cell projection, cilium, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, extracellular region, lateral wall of outer hair cell, manchette, microtubule, microtubule cytoskeleton, motile cilium, sperm principal piece
Pathways:
UniProt: Q9JLI7
Entrez ID: 50525
|
Does Knockout of Phactr4 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Phactr4
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Phactr4 (phosphatase and actin regulator 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, actin cytoskeleton organization, closure of optic fissure, enteric nervous system development, negative regulation of integrin-mediated signaling pathway, nervous system development, neural crest cell migration, neural tube closure, positive regulation of catalytic activity, regulation of cell cycle; MF: actin binding, protein phosphatase 1 binding, protein phosphatase activator activity, protein phosphatase inhibitor activity; CC: cell projection, cytoplasm, lamellipodium
Pathways:
UniProt: Q501J7
Entrez ID: 100169
|
Does Knockout of Vps53 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Vps53
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vps53 (VPS53 GARP complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytosolic transport, endocytic recycling, lysosomal transport, protein targeting to lysosome, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated cholesterol transport, vesicle-mediated transport; CC: EARP complex, GARP complex, Golgi apparatus, cytosol, endosome, endosome membrane, membrane, perinuclear region of cytoplasm, recycling endosome, trans-Golgi network
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q8CCB4
Entrez ID: 68299
|
Does Knockout of Tpbpa in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Tpbpa
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tpbpa (trophoblast specific protein alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A286YCU7, Q9CPR0, A0A286YCI4
Entrez ID: 21984
|
Does Knockout of 1810065E05Rik in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
1810065E05Rik
|
cell proliferation
|
Melanoma Cell Line
|
Gene: 1810065E05Rik (RIKEN cDNA 1810065E05 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D8K1, Q5NC41
Entrez ID: 69864
|
Does Knockout of Dpf2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Dpf2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Dpf2 (double PHD fingers 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, chromatin organization, chromatin remodeling, negative regulation of myeloid progenitor cell differentiation, nervous system development, positive regulation of double-strand break repair, positive regulation of stem cell population maintenance, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: histone H3K14ac reader activity, histone H4K16ac reader activity, metal ion binding, zinc ion binding; CC: SWI/SNF complex, centrosome, chromatin, cytoplasm, cytosol, nBAF complex, nucleoplasm, nucleus
Pathways:
UniProt: Q61103
Entrez ID: 19708
|
Does Knockout of Klrb1b in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Klrb1b
|
cell proliferation
|
Regulatory T cell
|
Gene: Klrb1b (killer cell lectin-like receptor subfamily B member 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of natural killer cell mediated cytotoxicity, regulation of natural killer cell mediated cytotoxicity; MF: carbohydrate binding, identical protein binding, protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Malaria - Mus musculus (mouse)
UniProt: Q99JB4
Entrez ID: 80782
|
Does Knockout of 6030458C11Rik in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
6030458C11Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 6030458C11Rik (RIKEN cDNA 6030458C11 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BGC1
Entrez ID: 77877
|
Does Knockout of Akr1a1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Akr1a1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Akr1a1 (aldo-keto reductase family 1, member A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucuronate catabolic process, D-glucuronate catabolic process to D-xylulose 5-phosphate, L-ascorbic acid biosynthetic process, aldehyde catabolic process, cellular detoxification of aldehyde, daunorubicin metabolic process, doxorubicin metabolic process, lipid metabolic process, negative regulation of apoptotic process; MF: L-glucuronate reductase activity, S-nitrosoglutathione reductase (NADH) activity, S-nitrosoglutathione reductase (NADPH) activity, alcohol dehydrogenase (NADP+) activity, aldose reductase (NADPH) activity, all-trans-retinol dehydrogenase (NAD+) activity, allyl-alcohol dehydrogenase activity, glucuronolactone reductase activity, glycerol dehydrogenase (NADP+) activity, methylglyoxal reductase (NADPH) (acetol producing) activity, oxidoreductase activity; CC: apical plasma membrane, cytoplasm, cytosol, membrane, plasma membrane, synapse
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), Biological oxidations, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), D-glucuronate degradation I, Formation of xylulose-5-phosphate, Glutathione conjugation, Glycerolipid metabolism - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), L-ascorbate biosynthesis VI, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose and glucuronate interconversions - Mus musculus (mouse), Phase II - Conjugation of compounds, Pyruvate metabolism - Mus musculus (mouse)
UniProt: Q9JII6
Entrez ID: 58810
|
Does Knockout of 4930474N05Rik in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
4930474N05Rik
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: 4930474N05Rik (RIKEN cDNA 4930474N05 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways:
UniProt: Q3V0P0, Q8BVR5
Entrez ID: 218921
|
Does Knockout of Map3k21 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Map3k21
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Map3k21 (mitogen-activated protein kinase kinase kinase 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, signal transduction; MF: ATP binding, JUN kinase kinase kinase activity, MAP kinase kinase kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: Q8VDG6
Entrez ID: 234878
|
Does Knockout of Ear-ps2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Ear-ps2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Ear-ps2 (eosinophil-associated, ribonuclease A family, pseudogene 2)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Itgae in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Itgae
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Itgae (integrin alpha E, epithelial-associated)
Type: protein-coding
Summary: Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; lymph node; nasal septum; and nucleus pulposus. Orthologous to human ITGAE (integrin subunit alpha E). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell adhesion, cell-cell adhesion, cell-matrix adhesion, integrin-mediated signaling pathway; MF: metal ion binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, integrin complex, membrane
Pathways: Extracellular matrix organization, Integrin cell surface interactions, Regulation of actin cytoskeleton - Mus musculus (mouse)
UniProt: Q60677
Entrez ID: 16407
|
Does Knockout of Gaa in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Gaa
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gaa (glucosidase, alpha, acid)
Type: protein-coding
Summary: This gene encodes a lysosomal acid glucosidase that is involved in the degradation of glycogen. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that cleaves alpha-1-4 and alpha-1-6 glycosidic bonds of glycogen, maltose and intermediate oligosaccharides within the lysosome. Mice lacking the encoded protein exhibit symptoms similar to human Pompe syndrome such as accumulation of glycogen in cardiac and skeletal muscle lysosomes resulting in reduced mobility and strength. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: aorta development, carbohydrate metabolic process, cardiac muscle contraction, diaphragm contraction, glycogen catabolic process, glycogen metabolic process, glycophagy, heart morphogenesis, locomotory behavior, lysosome organization, muscle cell cellular homeostasis, neuromuscular process controlling balance, neuromuscular process controlling posture, regulation of the force of heart contraction, striated muscle contraction, tissue development, vacuolar sequestering; MF: alpha-1,4-glucosidase activity, alpha-glucosidase activity, carbohydrate binding, catalytic activity, glucan 1,6-alpha-glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds; CC: autolysosome lumen, lysosomal membrane, lysosome, membrane
Pathways: Galactose metabolism - Mus musculus (mouse), Glycogen breakdown (glycogenolysis), Glycogen metabolism, Immune System, Innate Immune System, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Starch and sucrose metabolism - Mus musculus (mouse)
UniProt: P70699
Entrez ID: 14387
|
Does Knockout of Ccdc40 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,440
|
Knockout
|
Ccdc40
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ccdc40 (coiled-coil domain containing 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonemal dynein complex assembly, axoneme assembly, cilium movement, determination of digestive tract left/right asymmetry, determination of left/right symmetry, determination of liver left/right asymmetry, determination of pancreatic left/right asymmetry, epithelial cilium movement involved in determination of left/right asymmetry, epithelial cilium movement involved in extracellular fluid movement, flagellated sperm motility, heart looping, inner dynein arm assembly, lung development, motile cilium assembly, protein localization to cilium, regulation of cilium beat frequency; CC: axoneme, cell projection, cilium, cytoplasm, extracellular region, motile cilium
Pathways:
UniProt: Q8BI79
Entrez ID: 207607
|
Does Knockout of Hax1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Hax1
|
phagocytosis
|
macrophage
|
Gene: Hax1 (HCLS1 associated X-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, cellular response to cytokine stimulus, granulocyte colony-stimulating factor signaling pathway, negative regulation of apoptotic process, positive regulation of granulocyte differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transcription by RNA polymerase II, regulation of actin filament organization, regulation of actin filament polymerization; MF: interleukin-1 binding, protein binding, protein domain specific binding, signaling adaptor activity; CC: P-body, actin cytoskeleton, apical plasma membrane, cell cortex, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, lamellipodium, membrane, mitochondrial intermembrane space, mitochondrial matrix, mitochondrial outer membrane, mitochondrion, nuclear membrane, nucleus, plasma membrane, sarcoplasmic reticulum, transcription regulator complex
Pathways:
UniProt: O35387
Entrez ID: 23897
|
Does Knockout of 4933409G03Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
4933409G03Rik
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: 4933409G03Rik (RIKEN cDNA 4933409G03 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: F6YRC2, Q8C5U0
Entrez ID: 227998
|
Does Knockout of Mybph in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Mybph
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mybph (myosin binding protein H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, sarcomere organization; CC: M band, myosin filament
Pathways:
UniProt: P70402
Entrez ID: 53311
|
Does Knockout of Gls2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,663
|
Knockout
|
Gls2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gls2 (glutaminase 2 (liver, mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamine catabolic process, glutamate biosynthetic process, glutamine metabolic process, reactive oxygen species metabolic process, regulation of apoptotic process; MF: glutaminase activity, hydrolase activity; CC: mitochondrion
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Arginine biosynthesis - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), D-Amino acid metabolism - Mus musculus (mouse), GABAergic synapse - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glutamate Neurotransmitter Release Cycle, Glutamate and glutamine metabolism, Glutamatergic synapse - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, MicroRNAs in cancer - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, Proximal tubule bicarbonate reclamation - Mus musculus (mouse), RNA Polymerase II Transcription, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, Transmission across Chemical Synapses, citrulline biosynthesis, glutamine degradation I, glutamine degradation II, superpathway of citrulline metabolism
UniProt: Q571F8
Entrez ID: 216456
|
Does Knockout of Pelp1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Pelp1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Pelp1 (proline, glutamic acid and leucine rich protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to estrogen stimulus, positive regulation of transcription by RNA polymerase II, rRNA processing; MF: SUMO binding, chromatin binding, protein binding; CC: MLL1 complex, cytoplasm, euchromatin, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9DBD5
Entrez ID: 75273
|
Does Knockout of Rad9b in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Rad9b
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Rad9b (RAD9 checkpoint clamp component B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA repair, DNA replication checkpoint signaling, cellular response to ionizing radiation, mitotic intra-S DNA damage checkpoint signaling; CC: checkpoint clamp complex, nucleus
Pathways: Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, Cellular senescence - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q6WBX7
Entrez ID: 231724
|
Does Knockout of Gucy2g in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Gucy2g
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Gucy2g (guanylate cyclase 2g)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cGMP biosynthetic process, cyclic nucleotide biosynthetic process, intracellular signal transduction, receptor guanylyl cyclase signaling pathway; MF: ATP binding, GTP binding, guanylate cyclase activity, lyase activity, nucleotide binding, peptide receptor activity, phosphorus-oxygen lyase activity, protein kinase activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: Purine metabolism - Mus musculus (mouse), cyclic GMP biosynthesis
UniProt: Q6TL19
Entrez ID: 73707
|
Does Knockout of Gc in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Gc
|
phagocytosis
|
macrophage
|
Gene: Gc (vitamin D binding protein)
Type: protein-coding
Summary: Predicted to enable actin binding activity and calcidiol binding activity. Acts upstream of or within vitamin D metabolic process. Predicted to be located in axon; extracellular space; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; hemolymphoid system gland; liver; male reproductive gland or organ; and trigeminal nerve. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: response to nutrient levels, vitamin D metabolic process, vitamin transmembrane transport, vitamin transport; MF: actin binding, calcidiol binding, vitamin D binding, vitamin transmembrane transporter activity; CC: axon, extracellular region, extracellular space, perinuclear region of cytoplasm
Pathways: Metabolism, Metabolism of lipids, Metabolism of steroids, Vitamin D (calciferol) metabolism
UniProt: P21614
Entrez ID: 14473
|
Does Knockout of Map3k15 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Map3k15
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Map3k15 (mitogen-activated protein kinase kinase kinase 15)
Type: protein-coding
Summary: Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in JNK cascade and p38MAPK cascade. Is expressed in pancreas. Orthologous to human MAP3K15 (mitogen-activated protein kinase kinase kinase 15). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: JNK cascade, MAPK cascade, p38MAPK cascade; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: A2AQW0
Entrez ID: 270672
|
Does Knockout of Mterf2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Mterf2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mterf2 (mitochondrial transcription termination factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, nucleic acid binding; CC: mitochondrial matrix, mitochondrial nucleoid, mitochondrion
Pathways:
UniProt: Q8BKY8
Entrez ID: 74238
|
Does Knockout of Pdpn in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Pdpn
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pdpn (podoplanin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, actin-mediated cell contraction, amino acid transport, cell adhesion, cell migration, cell population proliferation, cell-cell adhesion, folic acid transport, lung alveolus development, lung development, lymph node development, lymphangiogenesis, lymphatic endothelial cell fate commitment, negative regulation of apoptotic process, negative regulation of cell population proliferation, positive regulation of cell migration, positive regulation of cell motility, positive regulation of epithelial to mesenchymal transition, positive regulation of extracellular matrix disassembly, positive regulation of platelet activation, positive regulation of platelet aggregation, prostaglandin metabolic process, regulation of G1/S transition of mitotic cell cycle, regulation of cell adhesion, regulation of cell shape, regulation of lamellipodium morphogenesis, regulation of myofibroblast contraction, regulation of substrate adhesion-dependent cell spreading, signal transduction, tube morphogenesis, visceral serous pericardium development, wound healing, spreading of cells; MF: amino acid transmembrane transporter activity, chemokine binding, folic acid transmembrane transporter activity, protein binding, protein-folding chaperone binding, signaling receptor binding; CC: anchoring junction, apical plasma membrane, basolateral plasma membrane, cell junction, cell projection, cytoplasmic vesicle, cytosol, external side of plasma membrane, filopodium, filopodium membrane, lamellipodium, lamellipodium membrane, leading edge of lamellipodium, membrane, membrane raft, microvillus membrane, mitochondrion, plasma membrane, ruffle, ruffle membrane, tetraspanin-enriched microdomain
Pathways: GPVI-mediated activation cascade, Hemostasis, Platelet activation, signaling and aggregation
UniProt: Q62011
Entrez ID: 14726
|
Does Knockout of Tlx1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Tlx1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tlx1 (T cell leukemia, homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, animal organ formation, cell fate commitment, central nervous system development, lymph node development, neuron differentiation, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spleen development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, protein binding; CC: nucleus
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: G3UXB9, Q9QX99
Entrez ID: 21908
|
Does Knockout of Ints3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Ints3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ints3 (integrator complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II transcription initiation surveillance, double-strand break repair via homologous recombination, mitotic G2/M transition checkpoint, response to ionizing radiation, snRNA processing; CC: INTAC complex, SOSS complex, cytoplasm, integrator complex, nucleus, site of double-strand break
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q7TPD0
Entrez ID: 229543
|
Does Knockout of Pdha2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Pdha2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pdha2 (pyruvate dehydrogenase E1 alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucose metabolic process, pyruvate decarboxylation to acetyl-CoA, tricarboxylic acid cycle; MF: metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, pyruvate dehydrogenase (acetyl-transferring) activity; CC: mitochondrial matrix, mitochondrion, nucleolus, oxidoreductase complex, pyruvate dehydrogenase complex
Pathways: Aerobic respiration and respiratory electron transport, Central carbon metabolism in cancer - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, PDH complex synthesizes acetyl-CoA from PYR, Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), Regulation of pyruvate dehydrogenase (PDH) complex, Regulation of pyruvate metabolism, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, acetyl-CoA biosynthesis (from pyruvate), superpathway of acetyl-CoA biosynthesis
UniProt: P35487
Entrez ID: 18598
|
Does Knockout of Gsdmc in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Gsdmc
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gsdmc (gasdermin C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to bacterium, programmed cell death, pyroptotic inflammatory response; MF: phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylserine binding, wide pore channel activity; CC: cytoplasm, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q99NB5
Entrez ID: 83492
|
Does Knockout of Cebpg in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Cebpg
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cebpg (CCAAT/enhancer binding protein gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, DNA-templated transcription, chromatin remodeling, enucleate erythrocyte differentiation, immune response, liver development, mRNA metabolic process, natural killer cell mediated cytotoxicity, negative regulation of DNA-binding transcription factor activity, nucleosome disassembly, positive regulation of DNA repair, positive regulation of transcription by RNA polymerase II, positive regulation of type II interferon production, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending, double-stranded DNA binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, nucleoplasm, nucleus
Pathways: Tuberculosis - Mus musculus (mouse)
UniProt: P53568
Entrez ID: 12611
|
Does Knockout of Manba in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Manba
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Manba (mannosidase, beta A, lysosomal)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, glycoprotein catabolic process; MF: D-mannose binding, beta-mannosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds; CC: extracellular space, lysosome
Pathways: Immune System, Innate Immune System, Lysosomal oligosaccharide catabolism, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Other glycan degradation - Mus musculus (mouse)
UniProt: Q8K2I4
Entrez ID: 110173
|
Does Knockout of Tapbp in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Tapbp
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tapbp (TAP binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MHC class Ib protein complex assembly, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, antigen processing and presentation of peptide antigen via MHC class I, defense response, peptide antigen assembly with MHC class I protein complex, peptide antigen stabilization, protein-containing complex assembly, regulation of gene expression, regulation of protein complex stability; MF: MHC class I protein complex binding, TAP complex binding, TAP1 binding, TAP2 binding, molecular adaptor activity, peptide antigen binding, protein binding, protein folding chaperone; CC: Golgi membrane, MHC class I peptide loading complex, Tapasin-ERp57 complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, phagocytic vesicle membrane, plasma membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, ER-Phagosome pathway, Epstein-Barr virus infection - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System
UniProt: Q9R233
Entrez ID: 21356
|
Does Knockout of Hcst in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Hcst
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hcst (hematopoietic cell signal transducer)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: natural killer cell mediated cytotoxicity, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of immune response; MF: phosphatidylinositol 3-kinase binding, protein binding, protein-macromolecule adaptor activity, signaling receptor binding; CC: cell surface, membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: Q9QUJ0
Entrez ID: 23900
|
Does Knockout of Tnfrsf11a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Tnfrsf11a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tnfrsf11a (tumor necrosis factor receptor superfamily, member 11a, NFKB activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, cellular response to zinc ion starvation, circadian temperature homeostasis, immune system process, lymph node development, mammary gland alveolus development, multinuclear osteoclast differentiation, ossification, osteoclast differentiation, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of bone resorption, positive regulation of canonical NF-kappaB signal transduction, positive regulation of fever generation by positive regulation of prostaglandin secretion, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of osteoclast differentiation, response to ethanol, response to insulin, response to interleukin-1, response to lipopolysaccharide, response to mechanical stimulus, response to tumor necrosis factor, tumor necrosis factor-mediated signaling pathway; MF: cytokine binding, metal ion binding, protein binding, transmembrane signaling receptor activity, tumor necrosis factor receptor activity; CC: cell surface, cytosol, external side of plasma membrane, membrane, membrane raft, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, NF-kappa B signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNFR2 non-canonical NF-kB pathway
UniProt: O35305
Entrez ID: 21934
|
Does Knockout of Rfc2 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Rfc2
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Rfc2 (replication factor C (activator 1) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, enzyme binding, nucleotide binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, nucleus
Pathways: Activation of ATR in response to replication stress, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9WUK4
Entrez ID: 19718
|
Does Knockout of Irs2 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Irs2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Irs2 (insulin receptor substrate 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cellular response to endothelin, cellular response to glucose stimulus, cellular response to insulin stimulus, epithelial cell migration, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, mammary gland development, negative regulation of B cell apoptotic process, negative regulation of long-chain fatty acid import across plasma membrane, positive regulation of B cell proliferation, positive regulation of D-glucose import, positive regulation of cell population proliferation, positive regulation of epithelial cell migration, positive regulation of fatty acid beta-oxidation, positive regulation of glucose metabolic process, positive regulation of glycogen biosynthetic process, positive regulation of insulin secretion, positive regulation of mesenchymal cell proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transport, positive regulation of type B pancreatic cell proliferation, response to glucose, signal transduction; MF: 14-3-3 protein binding, insulin receptor binding, phosphatidylinositol 3-kinase activator activity, phosphatidylinositol 3-kinase binding, protein binding, protein domain specific binding, protein kinase binding, protein phosphatase binding, protein-macromolecule adaptor activity, signaling adaptor activity, transmembrane receptor protein tyrosine kinase adaptor activity; CC: cytoplasm, cytosol, plasma membrane
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Axon guidance, Cytokine Signaling in Immune system, Developmental Biology, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Erythropoietin activates RAS, FoxO signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), IGF1R signaling cascade, IRS activation, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Insulin receptor signalling cascade, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interleukin-7 signaling, Intracellular signaling by second messengers, Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, MicroRNAs in cancer - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Nervous system development, Non-alcoholic fatty liver disease - Mus musculus (mouse), PI3K Cascade, PI3K/AKT activation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, RAF/MAP kinase cascade, RET signaling, Regulation of lipolysis in adipocytes - Mus musculus (mouse), SOS-mediated signalling, Signal Transduction, Signal attenuation, Signaling by Erythropoietin, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Type II diabetes mellitus - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P81122
Entrez ID: 384783
|
Does Knockout of Yme1l1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Yme1l1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Yme1l1 (YME1-like 1 (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation, cellular response to starvation, mitochondrial protein catabolic process, mitochondrial protein processing, mitochondrion organization, negative regulation of apoptotic process, neuronal stem cell population maintenance, positive regulation of mitochondrial fusion, protein hexamerization, protein quality control for misfolded or incompletely synthesized proteins, proteolysis, regulation of stem cell division; MF: ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, nucleotide binding, peptidase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, nuclear body
Pathways: Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Mitochondrial calcium ion transport, Processing of SMDT1, Transport of small molecules
UniProt: O88967
Entrez ID: 27377
|
Does Knockout of Foxn4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Foxn4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Foxn4 (forkhead box N4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amacrine cell differentiation, atrioventricular canal development, heart looping, nervous system development, neuron fate commitment, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of heart contraction, retina layer formation, ventral spinal cord interneuron differentiation, ventral spinal cord interneuron fate commitment; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, chromatin binding, cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q8K3Q3
Entrez ID: 116810
|
Does Knockout of Nhs in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Nhs
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nhs (NHS actin remodeling regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, lens development in camera-type eye; CC: Golgi apparatus, cell junction, nuclear body
Pathways: RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: B1AV60, B9EJX2
Entrez ID: 195727
|
Does Knockout of Igf2bp3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Igf2bp3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Igf2bp3 (insulin-like growth factor 2 mRNA binding protein 3)
Type: protein-coding
Summary: Predicted to enable N6-methyladenosine-containing RNA reader activity; mRNA 3'-UTR binding activity; and mRNA 5'-UTR binding activity. Predicted to be involved in CRD-mediated mRNA stabilization and nervous system development. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; liver; and sensory organ. Orthologous to human IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: CRD-mediated mRNA stabilization, mRNA transport, nervous system development, regulation of translation; MF: N6-methyladenosine-containing RNA reader activity, RNA binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, nucleic acid binding, protein binding; CC: P-body, cytoplasm, cytoplasmic stress granule, cytosol, nucleus
Pathways:
UniProt: Q9CPN8
Entrez ID: 140488
|
Does Knockout of Polr3f in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Polr3f
|
cell proliferation
|
Regulatory T cell
|
Gene: Polr3f (polymerase (RNA) III (DNA directed) polypeptide F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production, transcription by RNA polymerase III; MF: 4 iron, 4 sulfur cluster binding, double-stranded DNA binding, iron-sulfur cluster binding, metal ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, cytoplasm, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q921X6
Entrez ID: 70408
|
Does Knockout of Mkx in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Mkx
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mkx (mohawk homeobox)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cell development, cellular response to mechanical stimulus, collagen fibril organization, intratendonous ossification, muscle organ development, negative regulation of chondrocyte differentiation, negative regulation of fat cell differentiation, negative regulation of myoblast differentiation, negative regulation of ossification, negative regulation of transcription by RNA polymerase II, positive regulation of collagen biosynthetic process, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II, tendon cell differentiation, tendon formation, tendon sheath development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, protein binding; CC: nucleus, transcription regulator complex
Pathways:
UniProt: Q8BIA3
Entrez ID: 210719
|
Does Knockout of Fgf23 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Fgf23
|
cell proliferation
|
Regulatory T cell
|
Gene: Fgf23 (fibroblast growth factor 23)
Type: protein-coding
Summary: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: ERK1 and ERK2 cascade, MAPK cascade, calcium ion homeostasis, cell differentiation, fibroblast growth factor receptor signaling pathway, intracellular phosphate ion homeostasis, negative regulation of bone mineralization, negative regulation of hormone secretion, negative regulation of osteoblast differentiation, neurogenesis, phosphate ion homeostasis, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of cell population proliferation, regulation of bone mineralization, regulation of cell migration, regulation of phosphate transport, response to sodium phosphate, vitamin D catabolic process; MF: fibroblast growth factor receptor binding, growth factor activity, protein binding, type 1 fibroblast growth factor receptor binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, FGFR1 ligand binding and activation, FGFR1c and Klotho ligand binding and activation, FGFR1c ligand binding and activation, FGFR2 ligand binding and activation, FGFR2c ligand binding and activation, FGFR3 ligand binding and activation, FGFR3c ligand binding and activation, FGFR4 ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Gastric cancer - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Metabolism of proteins, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, Phospholipase C-mediated cascade; FGFR3, Phospholipase C-mediated cascade; FGFR4, Post-translational protein modification, Post-translational protein phosphorylation, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Regulation of actin cytoskeleton - Mus musculus (mouse), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: Q9EPC2
Entrez ID: 64654
|
Does Knockout of Il5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Il5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Il5 (interleukin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, eosinophil differentiation, immune response, interleukin-5-mediated signaling pathway, positive regulation of B cell proliferation, positive regulation of cell population proliferation, positive regulation of eosinophil differentiation, positive regulation of immunoglobulin production, positive regulation of podosome assembly, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of transcription by RNA polymerase II; MF: cytokine activity, growth factor activity, interleukin-5 receptor binding; CC: extracellular region, extracellular space
Pathways: Allograft rejection - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intestinal immune network for IgA production - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Pathways in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins, T cell receptor signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse)
UniProt: P04401
Entrez ID: 16191
|
Does Knockout of Irx2 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Irx2
|
phagocytosis
|
macrophage
|
Gene: Irx2 (Iroquois homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cell development, metanephros development, negative regulation of transcription by RNA polymerase II, neuron differentiation, proximal/distal pattern formation involved in metanephric nephron development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, specification of loop of Henle identity; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P81066
Entrez ID: 16372
|
Does Knockout of Zfp954 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Zfp954
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Zfp954 (zinc finger protein 954)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8BIA9, Q7TNU5
Entrez ID: 232853
|
Does Knockout of Oscp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Oscp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Oscp1 (organic solute carrier partner 1)
Type: protein-coding
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in cytoplasm. Is expressed in several structures, including brain ventricle; heart ventricle; and olfactory epithelium. Orthologous to human OSCP1 (organic solute carrier partner 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: xenobiotic detoxification by transmembrane export across the plasma membrane; MF: transmembrane transporter activity; CC: basal plasma membrane, cytoplasm, membrane, plasma membrane
Pathways:
UniProt: Q8BHW2
Entrez ID: 230751
|
Does Knockout of Prdx6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,680
|
Knockout
|
Prdx6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prdx6 (peroxiredoxin 6)
Type: protein-coding
Summary: This gene encodes a member of the peroxiredoxin family of peroxidases. The encoded protein is a bifunctional enzyme that has glutathione peroxidase and phospholipase activities. This protein is an antioxidant that reduces peroxidized membrane phospholipids and plays an important role in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis. Mice lacking this gene are sensitive to oxidant stress, have altered lung phospholipid metabolism and susceptible to skin tumorigenesis. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: bleb assembly, cell redox homeostasis, cellular oxidant detoxification, glycerophospholipid catabolic process, hydrogen peroxide catabolic process, lipid catabolic process, lipid metabolic process, positive regulation of mRNA splicing, via spliceosome, response to oxidative stress, response to reactive oxygen species; MF: 1-acylglycerophosphocholine O-acyltransferase activity, antioxidant activity, calcium-independent phospholipase A2 activity, catalytic activity, glutathione peroxidase activity, hydrolase activity, identical protein binding, oxidoreductase activity, peroxidase activity, peroxiredoxin activity, phospholipase A2 activity, protein binding, transferase activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, lysosome, mitochondrion, nucleus, perinuclear region of cytoplasm
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Glutathione metabolism - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation, phosphate acquisition II
UniProt: O08709
Entrez ID: 11758
|
Does Knockout of Kif21a in cardiac muscle cell line causally result in protein/peptide accumulation?
| 0
| 1,662
|
Knockout
|
Kif21a
|
protein/peptide accumulation
|
cardiac muscle cell line
|
Gene: Kif21a (kinesin family member 21A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal transport, cortical microtubule organization, microtubule-based movement, regulation of axon guidance, regulation of microtubule depolymerization, regulation of microtubule polymerization; MF: ATP binding, ATP hydrolysis activity, ankyrin repeat binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity; CC: axon, axon cytoplasm, axonal growth cone, cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, dendrite, growth cone, kinesin complex, microtubule, presynapse
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9QXL2
Entrez ID: 16564
|
Does Knockout of Ugcg in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Ugcg
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ugcg (UDP-glucose ceramide glucosyltransferase)
Type: protein-coding
Summary: Enables ceramide glucosyltransferase activity. Involved in several processes, including cornified envelope assembly; establishment of skin barrier; and glucosylceramide biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in membrane. Is expressed in several structures, including blastocyst; brain; early embryo; liver; and oocyte. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, cornified envelope assembly, establishment of skin barrier, glucosylceramide biosynthetic process, intestinal lipid absorption, keratinocyte differentiation, leptin-mediated signaling pathway, lipid metabolic process, neuron development, protein lipidation, regulation of signal transduction, sphingolipid metabolic process; MF: ceramide glucosyltransferase activity, glycosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosphingolipid biosynthesis, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse)
UniProt: O88693
Entrez ID: 22234
|
Does Knockout of Amdhd2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Amdhd2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Amdhd2 (amidohydrolase domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-acetylglucosamine catabolic process, N-acetylglucosamine metabolic process, N-acetylneuraminate catabolic process, negative regulation of UDP-N-acetylglucosamine biosynthetic process; MF: N-acetylglucosamine-6-phosphate deacetylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, metal ion binding
Pathways: <i>N</i>-acetylglucosamine degradation I, <i>N</i>-acetylglucosamine degradation II, Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, Post-translational protein modification, Synthesis of UDP-N-acetyl-glucosamine, Synthesis of substrates in N-glycan biosythesis, superpathway of <i>N</i>-acetylglucosamine, <i>N</i>-acetylmannosamine and <i>N</i>-acetylneuraminate degradation
UniProt: Q8JZV7
Entrez ID: 245847
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.