prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Wasf3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Wasf3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Wasf3 (WASP family, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, cytoskeleton organization, lamellipodium assembly, lamellipodium organization, modification of postsynaptic actin cytoskeleton, oligodendrocyte development, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of myelination, regulation of cell shape; MF: Arp2/3 complex binding, actin binding, protein kinase A regulatory subunit binding; CC: SCAR complex, cytoplasm, cytoskeleton, glial cell projection, glutamatergic synapse, lamellipodium, postsynapse
Pathways: Adherens junction - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, RAC1 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: Q8VHI6
Entrez ID: 245880
|
Does Knockout of Snap91 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Snap91
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Snap91 (synaptosomal-associated protein 91)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, chemical synaptic transmission, clathrin coat assembly, clathrin-dependent endocytosis, establishment or maintenance of cell polarity, neuron development, neurotransmitter secretion, positive regulation of axonogenesis, positive regulation of clathrin coat assembly, positive regulation of synaptic vesicle clustering, positive regulation of synaptic vesicle endocytosis, protein transport, regulation of clathrin-dependent endocytosis, regulation of endocytosis, regulation of protein transport, regulation of synaptic vesicle endocytosis, regulation of terminal button organization, synaptic vesicle endocytosis, vesicle budding from membrane; MF: 1-phosphatidylinositol binding, SH2 domain binding, SNARE binding, clathrin adaptor activity, clathrin binding, clathrin heavy chain binding, inositol hexakisphosphate binding, molecular adaptor activity, phosphatidylinositol-4,5-bisphosphate binding, phospholipase C inhibitor activity, phospholipase D inhibitor activity, phospholipase binding, phospholipid binding, protein binding, protein kinase binding; CC: AP-2 adaptor complex, Schaffer collateral - CA1 synapse, axon terminus, clathrin-coated pit, clathrin-coated vesicle, cytosol, extrinsic component of presynaptic endocytic zone membrane, membrane, neuronal cell body, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic active zone membrane, presynaptic membrane, synaptic vesicle
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q61548
Entrez ID: 20616
|
Does Knockout of Cmtm4 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Cmtm4
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Cmtm4 (CKLF-like MARVEL transmembrane domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane
Pathways:
UniProt: Q8CJ61
Entrez ID: 97487
|
Does Knockout of Cep152 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Cep152
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Cep152 (centrosomal protein 152)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, centriole replication, centrosome duplication, de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; MF: protein binding, protein kinase binding; CC: centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, deuterosome, nuclear body, nucleoplasm, pericentriolar material, procentriole, procentriole replication complex
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: A2AUM9
Entrez ID: 99100
|
Does Knockout of Col10a1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Col10a1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Col10a1 (collagen, type X, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone development, cartilage development, endochondral ossification; MF: extracellular matrix structural constituent conferring tensile strength, metal ion binding; CC: cell cortex, collagen trimer, collagen type X trimer, extracellular matrix, extracellular region, receptor complex
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Extracellular matrix organization, Non-integrin membrane-ECM interactions, Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q05306
Entrez ID: 12813
|
Does Knockout of Fam151b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Fam151b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fam151b (family with sequence similarity 151, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, photoreceptor cell development
Pathways:
UniProt: D3YUE4
Entrez ID: 73942
|
Does Knockout of Suclg1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Suclg1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Suclg1 (succinate-CoA ligase, GDP-forming, alpha subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: succinate metabolic process, succinyl-CoA metabolic process, tricarboxylic acid cycle; MF: GDP binding, catalytic activity, ligase activity, nucleotide binding, protein binding, protein-containing complex binding, succinate-CoA ligase (ADP-forming) activity, succinate-CoA ligase (GDP-forming) activity; CC: mitochondrial inner membrane, mitochondrion, protein-containing complex, succinate-CoA ligase complex (ADP-forming), succinate-CoA ligase complex (GDP-forming)
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Metabolism, Propanoate metabolism - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), glutamate degradation VII
UniProt: Q9WUM5
Entrez ID: 56451
|
Does Knockout of Rln1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Rln1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Rln1 (relaxin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenylate cyclase-modulating G protein-coupled receptor signaling pathway, developmental growth, mammary gland morphogenesis, negative regulation of apoptotic process, nipple development, prostate gland growth, regulation of apoptotic process, regulation of cell population proliferation, regulation of nitric oxide mediated signal transduction, spermatogenesis; MF: hormone activity, signaling receptor binding
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse)
UniProt: A2RTV8
Entrez ID: 19773
|
Does Knockout of Urm1 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Urm1
|
response to virus
|
Microglial Cell Line
|
Gene: Urm1 (ubiquitin related modifier 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble uridine modification; MF: protein tag activity, sulfur carrier activity; CC: cytoplasm, cytosol, nucleus
Pathways: Sulfur relay system - Mus musculus (mouse)
UniProt: Q9D2P4
Entrez ID: 68205
|
Does Knockout of Pik3r1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Pik3r1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, T follicular helper cell differentiation, cellular response to UV, cellular response to insulin stimulus, cytokine-mediated signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, glucose metabolic process, growth hormone receptor signaling pathway, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, interleukin-18-mediated signaling pathway, intracellular glucose homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, myeloid leukocyte migration, natural killer cell mediated cytotoxicity, negative regulation of apoptotic process, negative regulation of blood pressure, negative regulation of cell adhesion, negative regulation of cell-cell adhesion, negative regulation of cell-matrix adhesion, negative regulation of heart rate, negative regulation of multicellular organismal process, negative regulation of muscle cell apoptotic process, negative regulation of osteoclast differentiation, negative regulation of proteolysis, negative regulation of smooth muscle cell proliferation, negative regulation of stress fiber assembly, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol metabolic process, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, positive regulation of RNA splicing, positive regulation of cell migration, positive regulation of cellular component biogenesis, positive regulation of cellular component organization, positive regulation of endoplasmic reticulum unfolded protein response, positive regulation of filopodium assembly, positive regulation of focal adhesion disassembly, positive regulation of gene expression, positive regulation of lamellipodium assembly, positive regulation of leukocyte migration, positive regulation of myoblast differentiation, positive regulation of protein import into nucleus, positive regulation of smooth muscle cell proliferation, positive regulation of synapse assembly, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, protein import into nucleus, protein stabilization, protein transport, regulation of protein localization to plasma membrane, regulation of stress fiber assembly, regulation of toll-like receptor 4 signaling pathway, response to cAMP, response to endoplasmic reticulum stress, response to glucocorticoid, response to insulin, signal transduction; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, ATPase binding, ErbB-3 class receptor binding, GTPase activator activity, calmodulin binding, insulin binding, insulin receptor binding, insulin receptor substrate binding, insulin-like growth factor receptor binding, kinase activator activity, neurotrophin TRKA receptor binding, nuclear estrogen receptor binding, phosphatidylinositol 3-kinase regulator activity, phosphatidylinositol 3-kinase regulatory subunit binding, phosphoprotein binding, phosphotyrosine residue binding, platelet-derived growth factor receptor binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein kinase binding, protein phosphatase binding, receptor tyrosine kinase binding, signaling receptor binding, ubiquitin protein ligase binding; CC: cell-cell junction, cis-Golgi network, cytoplasm, cytosol, membrane, nucleus, perinuclear endoplasmic reticulum membrane, perinuclear region of cytoplasm, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA, protein-containing complex
Pathways: 3-phosphoinositide biosynthesis, AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, CDC42 GTPase cycle, Carbohydrate digestion and absorption - Mus musculus (mouse), Cell surface interactions at the vascular wall, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Co-stimulation by CD28, Co-stimulation by ICOS, Colorectal cancer - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Downstream TCR signaling, Downstream signal transduction, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, ESR-mediated signaling, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, FLT3 Signaling, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G alpha (q) signalling events, GAB1 signalosome, GP1b-IX-V activation signalling, GPCR downstream signalling, GPVI-mediated activation cascade, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Innate Immune System, Insulin receptor signalling cascade, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-7 signaling, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, MET activates PI3K/AKT signaling, Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Metabolism, Metabolism of lipids, MicroRNAs in cancer - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI Metabolism, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K events in ERBB2 signaling, PI3K events in ERBB4 signaling, PI3K-Akt signaling pathway - Mus musculus (mouse), PI3K/AKT activation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP metabolism, PIP3 activates AKT signaling, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Prion disease - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RAF/MAP kinase cascade, RET signaling, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, RHOJ GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, RND1 GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Regulation of signaling by CBL, Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Role of LAT2/NTAL/LAB on calcium mobilization, Role of phospholipids in phagocytosis, Signal Transduction, Signaling by ALK, Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by Erythropoietin, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by LTK, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Nuclear Receptors, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by VEGF, Signaling by the B Cell Receptor (BCR), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Synthesis of PIPs at the plasma membrane, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling, TNF signaling pathway - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tie2 Signaling, Toll-like receptor signaling pathway - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P26450
Entrez ID: 18708
|
Does Knockout of Zfp746 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Zfp746
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp746 (zinc finger protein 746)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, protein heterooligomerization, protein homooligomerization, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, transcription cis-regulatory region binding, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q3U133
Entrez ID: 69228
|
Does Knockout of Zmym2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Zmym2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zmym2 (zinc finger, MYM-type 2)
Type: protein-coding
Summary: This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: negative regulation of DNA-templated transcription; MF: metal ion binding, protein binding, ubiquitin conjugating enzyme binding, zinc ion binding; CC: PML body, nucleus
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Negative Regulation of CDH1 Gene Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q9CU65
Entrez ID: 76007
|
Does Knockout of Suz12 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Suz12
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Suz12 (SUZ12 polycomb repressive complex 2 subunit)
Type: protein-coding
Summary: This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: chromatin organization, facultative heterochromatin formation, negative regulation of cell differentiation, negative regulation of chemokine production, negative regulation of epithelial cell proliferation, negative regulation of transcription by RNA polymerase II, oligodendrocyte differentiation, positive regulation of cell population proliferation, random inactivation of X chromosome, response to retinoic acid, spinal cord development; MF: RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, enzyme activator activity, histone H3K9me2/3 reader activity, histone methyltransferase activity, lncRNA binding, metal ion binding, promoter-specific chromatin binding, protein binding, sequence-specific DNA binding, transcription corepressor binding, zinc ion binding; CC: ESC/E(Z) complex, RSC-type complex, chromatin silencing complex, chromosome, nuclear body, nucleolus, nucleoplasm, nucleus, protein-DNA complex, ribonucleoprotein complex, sex chromatin
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Co-inhibition by PD-1, Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Metabolism of proteins, Negative Regulation of CDH1 Gene Transcription, Oxidative Stress Induced Senescence, PKMTs methylate histone lysines, PRC2 methylates histones and DNA, Post-translational protein modification, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of chromatin organization proteins, Transcriptional Regulation by E2F6
UniProt: Q80U70
Entrez ID: 52615
|
Does Knockout of Mtmr12 in Microglial Cell Line causally result in phagocytosis?
| 0
| 1,587
|
Knockout
|
Mtmr12
|
phagocytosis
|
Microglial Cell Line
|
Gene: Mtmr12 (myotubularin related protein 12)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in sarcomere and sarcoplasmic reticulum. Predicted to be active in cytoplasm and membrane. Orthologous to human MTMR12 (myotubularin related protein 12). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: CC: cytoplasm, membrane, sarcomere, sarcoplasmic reticulum
Pathways: Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism, Synthesis of PIPs at the early endosome membrane
UniProt: Q80TA6
Entrez ID: 268783
|
Does Knockout of Cfap20 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Cfap20
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cfap20 (cilia and flagella associated protein 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, flagellated sperm motility, positive regulation of cell motility, positive regulation of feeding behavior, protein polyglutamylation, regulation of cilium beat frequency involved in ciliary motility; CC: axonemal B tubule inner sheath, axonemal microtubule, cell projection, centriole, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule, motile cilium, nucleoplasm, nucleus, sperm flagellum
Pathways:
UniProt: Q8BTU1
Entrez ID: 14894
|
Does Knockout of Spr in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Spr
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Spr (sepiapterin reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-phenylalanine metabolic process, cell morphogenesis involved in neuron differentiation, dopamine metabolic process, nitric oxide biosynthetic process, norepinephrine metabolic process, pteridine metabolic process, regulation of multicellular organism growth, serotonin metabolic process, tetrahydrobiopterin biosynthetic process, tetrahydrobiopterin metabolic process, voluntary musculoskeletal movement; MF: oxidoreductase activity, protein homodimerization activity, sepiapterin reductase (NADP+) activity; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm
Pathways: Folate biosynthesis - Mus musculus (mouse), tetrahydrobiopterin biosynthesis I, tetrahydrobiopterin biosynthesis II
UniProt: G3UZ79, Q91XH5, G3UXX3
Entrez ID: 20751
|
Does Knockout of Esx1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Esx1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Esx1 (extraembryonic, spermatogenesis, homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel development, labyrinthine layer blood vessel development, labyrinthine layer morphogenesis, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, neuron development, regulation of DNA-templated transcription, regulation of cell cycle, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nuclear speck, nucleus
Pathways: Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: A2AG22, O88933, G3UXJ1
Entrez ID: 13984
|
Does Knockout of Tas2r120 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Tas2r120
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tas2r120 (taste receptor, type 2, member 120)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane, motile cilium
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse)
UniProt: Q7M721
Entrez ID: 387348
|
Does Knockout of Sec61g in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Sec61g
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sec61g (SEC61 translocon subunit gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, post-translational protein targeting to membrane, translocation, protein targeting, protein transport; MF: protein transmembrane transporter activity, ribosome binding; CC: Sec61 translocon complex, Ssh1 translocon complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, Phagosome - Mus musculus (mouse), Protein export - Mus musculus (mouse), Protein localization, Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: P60060
Entrez ID: 20335
|
Does Knockout of Jrk in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Jrk
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Jrk (jerky)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of canonical Wnt signaling pathway; MF: DNA binding, mRNA binding, nucleic acid binding; CC: cytoplasm, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q60976
Entrez ID: 16469
|
Does Knockout of Ndufaf2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Ndufaf2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ndufaf2 (NADH:ubiquinone oxidoreductase complex assembly factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, mitochondrial respiratory chain complex I assembly, negative regulation of insulin secretion involved in cellular response to glucose stimulus; MF: protein-containing complex binding; CC: membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q59J78
Entrez ID: 75597
|
Does Knockout of Rdh16 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Rdh16
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rdh16 (retinol dehydrogenase 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 9-cis-retinoic acid biosynthetic process, androgen biosynthetic process, lipid metabolic process, positive regulation of retinoic acid biosynthetic process, retinoic acid metabolic process, retinoid metabolic process, retinol metabolic process, steroid metabolic process; MF: 11-cis-retinol dehydrogenase (NAD+) activity, all-trans-retinol dehydrogenase (NAD+) activity, androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, identical protein binding, oxidoreductase activity; CC: endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, organelle membrane
Pathways: Retinol metabolism - Mus musculus (mouse)
UniProt: O54909
Entrez ID: 19683
|
Does Knockout of Tlr13 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Tlr13
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tlr13 (toll-like receptor 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MyD88-dependent toll-like receptor signaling pathway, immune system process, inflammatory response, innate immune response, regulation of MAPK cascade, response to virus, signal transduction, toll-like receptor 13 signaling pathway, toll-like receptor signaling pathway; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, RNA binding, identical protein binding, protein binding, rRNA binding, signaling receptor activity; CC: cytoplasm, endosome, endosome membrane, membrane, plasma membrane
Pathways:
UniProt: Q6R5N8
Entrez ID: 279572
|
Does Knockout of Tmem132b in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Tmem132b
|
response to bacteria
|
renal medulla cell line
|
Gene: Tmem132b (transmembrane protein 132B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: V9GX71, F7BAB2
Entrez ID: 208151
|
Does Knockout of Arpp19 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Arpp19
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Arpp19 (cAMP-regulated phosphoprotein 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, cell division, mitotic cell cycle, positive regulation of gluconeogenesis; MF: phosphatase inhibitor activity, potassium channel regulator activity, protein phosphatase 2A binding, protein phosphatase inhibitor activity, protein phosphatase regulator activity, signaling receptor binding; CC: cytoplasm, cytosol, dendrite, synapse
Pathways: Cell Cycle, Cell Cycle, Mitotic, M Phase, MASTL Facilitates Mitotic Progression, Mitotic Prophase
UniProt: P56212
Entrez ID: 59046
|
Does Knockout of Mdfi in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Mdfi
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mdfi (MyoD family inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, dorsal/ventral axis specification, embryonic skeletal system morphogenesis, maintenance of protein location in cell, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, regulation of JNK cascade, regulation of Wnt signaling pathway, regulation of gene expression, trophoblast giant cell differentiation; MF: DNA-binding transcription factor binding, identical protein binding, protein binding, protein sequestering activity; CC: cytoplasm, nucleus
Pathways:
UniProt: P70331
Entrez ID: 17240
|
Does Knockout of Pdlim3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Pdlim3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pdlim3 (PDZ and LIM domain 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament organization, heart development, muscle structure development; MF: actin binding, actinin binding, cytoskeletal protein binding, metal ion binding, muscle alpha-actinin binding, protein binding, structural constituent of muscle; CC: Z disc, actin cytoskeleton, adherens junction, cytoplasm, cytosol, filamentous actin, stress fiber
Pathways:
UniProt: O70209
Entrez ID: 53318
|
Does Knockout of D130052B06Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
D130052B06Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: D130052B06Rik (RIKEN cDNA D130052B06 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Insl3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Insl3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Insl3 (insulin-like 3)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor binding activity and protease binding activity. Involved in regulation of male gonad development. Acts upstream of or within in utero embryonic development and male gonad development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in extracellular space. Is expressed in Leydig cell; cornea; ovary; testis; and trunk. Used to study cryptorchidism. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human INSL3 (insulin like 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, in utero embryonic development, male gonad development, negative regulation of apoptotic process, negative regulation of cell population proliferation, oocyte maturation, positive regulation of cAMP/PKA signal transduction, positive regulation of cell population proliferation, positive regulation of epithelial cell migration, positive regulation of wound healing, regulation of male gonad development; MF: hormone activity, protease binding; CC: extracellular region, extracellular space, perinuclear region of cytoplasm
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse)
UniProt: Q5RL10
Entrez ID: 16336
|
Does Knockout of Klra9 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Klra9
|
response to virus
|
Microglial Cell Line
|
Gene: Klra9 (killer cell lectin-like receptor subfamily A, member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, signaling receptor activity; CC: cell surface, membrane, plasma membrane
Pathways: Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: Q2TJJ8
Entrez ID: 16640
|
Does Knockout of Adamts2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Adamts2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Adamts2 (ADAM metallopeptidase with thrombospondin type 1 motif 2)
Type: protein-coding
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: collagen catabolic process, collagen fibril organization, extracellular matrix organization, lung development, protein processing, proteolysis, skin development, spermatogenesis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular region
Pathways: Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization, Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8C9W3
Entrez ID: 216725
|
Does Knockout of Sptbn2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Sptbn2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sptbn2 (spectrin beta, non-erythrocytic 2)
Type: protein-coding
Summary: A structural constituent of postsynapse. Involved in postsynapse organization and regulation of postsynaptic specialization assembly. Acts upstream of or within adult behavior; cerebellar Purkinje cell layer morphogenesis; and synapse assembly. Located in apical plasma membrane and neuronal cell body. Is active in several cellular components, including parallel fiber to Purkinje cell synapse; paranodal junction; and postsynaptic spectrin-associated cytoskeleton. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skin. Used to study spinocerebellar ataxia type 5. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 14 and spinocerebellar ataxia type 5. Orthologous to human SPTBN2 (spectrin beta, non-erythrocytic 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actin cytoskeleton organization, actin filament capping, adult behavior, cerebellar Purkinje cell layer morphogenesis, multicellular organism growth, postsynapse organization, regulation of postsynaptic specialization assembly, synapse assembly, synaptic vesicle exocytosis, vesicle-mediated transport; MF: actin binding, actin filament binding, phospholipid binding, structural constituent of cytoskeleton, structural constituent of postsynapse, structural constituent of synapse; CC: Golgi membrane, apical plasma membrane, cell cortex, cell junction, cell projection, cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, endosome, glutamatergic synapse, membrane, neuronal cell body, parallel fiber to Purkinje cell synapse, paranodal junction, perinuclear region of cytoplasm, photoreceptor inner segment, plasma membrane, postsynaptic spectrin-associated cytoskeleton, presynapse, spectrin, synaptic vesicle
Pathways: Adaptive Immune System, Asparagine N-linked glycosylation, Axon guidance, COPI-mediated anterograde transport, Developmental Biology, ER to Golgi Anterograde Transport, Immune System, Interaction between L1 and Ankyrins, L1CAM interactions, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, NCAM signaling for neurite out-growth, Nervous system development, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, RAF/MAP kinase cascade, Signal Transduction, Spinocerebellar ataxia - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: A0A494BBH5, Q68FG2, A0A5F8MPM8
Entrez ID: 20743
|
Does Knockout of Cacna2d2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Cacna2d2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, muscle cell development, neuromuscular junction development, positive regulation of organ growth, regulation of multicellular organism growth, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, rhythmic synaptic transmission; MF: calcium channel activity, metal ion binding, voltage-gated calcium channel activity; CC: GABA-ergic synapse, membrane, monoatomic ion channel complex, plasma membrane, presynaptic active zone membrane, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Integration of energy metabolism, MAPK signaling pathway - Mus musculus (mouse), Metabolism, Muscle contraction, Neuronal System, Oxytocin signaling pathway - Mus musculus (mouse), Phase 0 - rapid depolarisation, Phase 2 - plateau phase, Presynaptic depolarization and calcium channel opening, Regulation of insulin secretion, Transmission across Chemical Synapses
UniProt: Q6PHS9
Entrez ID: 56808
|
Does Knockout of Tufm in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Tufm
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tufm (Tu translation elongation factor, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translational elongation, translation, translational elongation; MF: GTP binding, GTPase activity, hydrolase activity, magnesium ion binding, metal ion binding, nucleotide binding, translation elongation factor activity; CC: mitochondrial inner membrane, mitochondrial nucleoid, mitochondrion, myelin sheath, synapse
Pathways:
UniProt: Q8BFR5
Entrez ID: 233870
|
Does Knockout of Aadacl4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Aadacl4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Aadacl4 (arylacetamide deacetylase like 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: B1AVU5
Entrez ID: 435815
|
Does Knockout of Cngb1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Cngb1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cngb1 (cyclic nucleotide gated channel beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium ion transmembrane transport, calcium ion transport, detection of chemical stimulus involved in sensory perception of smell, detection of light stimulus involved in visual perception, membrane depolarization, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, olfactory nerve maturation, photoreceptor cell maintenance, photoreceptor cell outer segment organization, phototransduction, positive regulation of gene expression, potassium ion transport, regulation of cytosolic calcium ion concentration, response to odorant, retina homeostasis, sensory perception of smell, sodium ion transmembrane transport, sodium ion transport, visual perception; MF: cAMP binding, cGMP binding, calcium channel activity, cyclic nucleotide-activated monoatomic ion channel activity, intracellularly cAMP-activated cation channel activity, intracellularly cGMP-activated cation channel activity, intracellularly cyclic nucleotide-activated monoatomic cation channel activity, nucleotide binding, protein-containing complex binding, sodium channel activity; CC: cell projection, ciliary membrane, intracellular cyclic nucleotide activated cation channel complex, membrane, non-motile cilium membrane, photoreceptor outer segment, plasma membrane, rod photoreceptor outer segment, terminal bouton, transmembrane transporter complex
Pathways: Activation of the phototransduction cascade, Cargo trafficking to the periciliary membrane, Cilium Assembly, Inactivation, recovery and regulation of the phototransduction cascade, Olfactory transduction - Mus musculus (mouse), Organelle biogenesis and maintenance, Phototransduction - Mus musculus (mouse), Sensory Perception, The phototransduction cascade, Visual phototransduction, VxPx cargo-targeting to cilium, cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: E1AZ71
Entrez ID: 333329
|
Does Knockout of Ctso in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Ctso
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ctso (cathepsin O)
Type: protein-coding
Summary: This gene encodes a member of the cathepsin family of cysteine proteases that are involved in the degradation of cellular proteins. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: proteolysis, proteolysis involved in protein catabolic process; MF: cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: extracellular space, lysosome
Pathways: Adaptive Immune System, Apoptosis - Mus musculus (mouse), Immune System, Lysosome - Mus musculus (mouse), MHC class II antigen presentation
UniProt: Q8BM88
Entrez ID: 229445
|
Does Knockout of Aacs in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Aacs
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Aacs (acetoacetyl-CoA synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to glucose stimulus, fatty acid metabolic process, lipid metabolic process, liver development, positive regulation of insulin secretion, response to ethanol, response to nutrient, response to oleic acid, response to xenobiotic stimulus, small molecule metabolic process; MF: ATP binding, acetoacetate-CoA ligase activity, ligase activity, nucleotide binding, short-chain fatty acid-CoA ligase activity; CC: cytoplasm, cytosol
Pathways: Butanoate metabolism - Mus musculus (mouse), Ketone body metabolism, Metabolism, Metabolism of lipids, Synthesis of Ketone Bodies, Valine, leucine and isoleucine degradation - Mus musculus (mouse)
UniProt: Q9D2R0
Entrez ID: 78894
|
Does Knockout of Usp28 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,196
|
Knockout
|
Usp28
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Usp28 (ubiquitin specific peptidase 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, cell population proliferation, cellular response to UV, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, protein deubiquitination, protein deubiquitination involved in ubiquitin-dependent protein catabolic process, proteolysis, regulation of protein stability, response to ionizing radiation; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, peptidase activity; CC: cytosol, nuclear body, nucleoplasm, nucleus, protein-containing complex
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q5I043
Entrez ID: 235323
|
Does Knockout of Ak6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Ak6
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ak6 (adenylate kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleoside monophosphate phosphorylation, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: AMP kinase activity, ATP binding, ATP hydrolysis activity, kinase activity, nucleotide binding, transferase activity; CC: Cajal body, centrosome, cytoplasm, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q8VCP8
Entrez ID: 102216272
|
Does Knockout of Mbl2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Mbl2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mbl2 (mannose-binding lectin (protein C) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of membrane attack complex, antiviral innate immune response, cell surface pattern recognition receptor signaling pathway, complement activation, complement activation, classical pathway, complement activation, lectin pathway, defense response to Gram-positive bacterium, immune system process, innate immune response, killing by host of symbiont cells, killing of cells of another organism, leukocyte chemotaxis involved in immune response, negative regulation of viral process, opsonization, positive regulation of complement activation, positive regulation of opsonization, positive regulation of phagocytosis, positive regulation of protein processing, protein maturation, proteolysis, surfactant homeostasis, zymogen activation; MF: D-mannose binding, calcium ion binding, calcium-dependent protein binding, carbohydrate binding, galactose binding, identical protein binding, pattern recognition receptor activity, phosphatidylinositol-4-phosphate binding, protease binding, signaling receptor binding; CC: collagen trimer, extracellular region, extracellular space, multivesicular body, protein-containing complex, serine-type endopeptidase complex, symbiont cell surface
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Coronavirus disease - COVID-19 - Mus musculus (mouse), Creation of C4 and C2 activators, Immune System, Initial triggering of complement, Innate Immune System, Lectin pathway of complement activation, Phagosome - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: P41317
Entrez ID: 17195
|
Does Knockout of Otop2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Otop2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Otop2 (otopetrin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, proton transmembrane transport; MF: proton channel activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q80SX5
Entrez ID: 237987
|
Does Knockout of Sdccag8 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Sdccag8
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Sdccag8 (serologically defined colon cancer antigen 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, centrosome cycle, establishment of cell polarity, microtubule organizing center organization, neuron migration, regulation of cilium assembly, tube formation; CC: anchoring junction, cell projection, cell-cell junction, centriolar satellite, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, nucleoplasm, photoreceptor cell cilium
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q80UF4
Entrez ID: 76816
|
Does Knockout of Acvr1b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Acvr1b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Acvr1b (activin A receptor, type 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, activin receptor signaling pathway, cardiac fibroblast cell development, cell surface receptor protein serine/threonine kinase signaling pathway, cell surface receptor signaling pathway, cellular response to growth factor stimulus, extrinsic apoptotic signaling pathway, hair follicle development, in utero embryonic development, mesoderm development, negative regulation of cell growth, negative regulation of gene expression, negative regulation of ossification, nervous system development, nodal signaling pathway, peptidyl-threonine phosphorylation, positive regulation of activin receptor signaling pathway, positive regulation of collagen biosynthetic process, positive regulation of erythrocyte differentiation, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, positive regulation of trophoblast cell migration, regulation of DNA-templated transcription, regulation of gene expression, regulation of signal transduction, signal transduction; MF: ATP binding, I-SMAD binding, SMAD binding, activin binding, activin receptor activity, activin receptor activity, type I, growth factor binding, inhibin binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transmembrane receptor protein serine/threonine kinase activity, ubiquitin protein ligase binding; CC: activin receptor complex, cell surface, membrane, plasma membrane, receptor complex
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by Activin, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: Q61271
Entrez ID: 11479
|
Does Knockout of Snhg11 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Snhg11
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Snhg11 (small nucleolar RNA host gene 11)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 319317
|
Does Knockout of Ankrd60 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Ankrd60
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ankrd60 (ankyrin repeat domain 60)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2AMD2, A0A6I8MWY2, A6PWV4
Entrez ID: 70065
|
Does Knockout of Tmem87b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Tmem87b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmem87b (transmembrane protein 87B)
Type: protein-coding
Summary: Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in Golgi cisterna membrane. Is expressed in medulla oblongata; medulla oblongata basal plate mantle layer; and spinal cord. Orthologous to human TMEM87B (transmembrane protein 87B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: retrograde transport, endosome to Golgi; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, cytosol, membrane
Pathways:
UniProt: Q8BKU8
Entrez ID: 72477
|
Does Knockout of Slco4a1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Slco4a1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Slco4a1 (solute carrier organic anion transporter family, member 4a1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, organic anion transport, prostaglandin transport, sodium-independent organic anion transport, thyroid hormone metabolic process, thyroid hormone transport, transmembrane transport; MF: organic anion transmembrane transporter activity, prostaglandin transmembrane transporter activity, sodium-independent organic anion transmembrane transporter activity, thyroid hormone transmembrane transporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: Organic anion transport by SLCO transporters, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: Q8K078
Entrez ID: 108115
|
Does Knockout of Ccr6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Ccr6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ccr6 (C-C motif chemokine receptor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DN2 thymocyte differentiation, DN3 thymocyte differentiation, G protein-coupled receptor signaling pathway, T cell migration, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, immune response, isotype switching to IgA isotypes, leukocyte migration involved in inflammatory response, lymphocyte migration, positive regulation of cytosolic calcium ion concentration, positive regulation of dendritic cell chemotaxis, positive regulation of epithelial cell migration, positive regulation of flagellated sperm motility involved in capacitation, regulation of T cell migration, regulation of T-helper 17 cell differentiation, signal transduction, thymocyte migration; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, chemokine receptor activity, protein binding; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, sperm flagellum, sperm midpiece, sperm plasma membrane, sperm principal piece
Pathways: Antimicrobial peptides, Beta defensins, Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Defensins, G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Immune System, Innate Immune System, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: O54689
Entrez ID: 12458
|
Does Knockout of Cox8c in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Cox8c
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cox8c (cytochrome c oxidase subunit 8C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: A6H666
Entrez ID: 75483
|
Does Knockout of Smad9 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Smad9
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Smad9 (SMAD family member 9)
Type: protein-coding
Summary: This gene encodes a member of a family of proteins that act as downstream effectors of the bone morphogenetic protein (BMP) signaling pathway. The encoded protein is phosphorylated by BMP receptors, which stimulates its binding to SMAD4 and translocation into the nucleus, where it functions as a regulator of transcription. Activity of this protein is important for embryonic development. Mutation of this gene results in defects in pulmonary vasculature. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: BMP signaling pathway, Mullerian duct regression, SMAD protein signal transduction, anatomical structure morphogenesis, bone development, cartilage development, cell differentiation, cellular response to growth factor stimulus, hindbrain development, intracellular iron ion homeostasis, midbrain development, osteoblast differentiation, positive regulation of DNA-templated transcription, positive regulation of cell differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal system development, stem cell differentiation, transforming growth factor beta receptor signaling pathway, transforming growth factor beta receptor superfamily signaling pathway, ureteric bud development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, I-SMAD binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding; CC: cytoplasm, cytosol, heteromeric SMAD protein complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Signal Transduction, Signaling by BMP, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: Q9JIW5
Entrez ID: 55994
|
Does Knockout of Daw1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Daw1
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Daw1 (dynein assembly factor with WDR repeat domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonemal dynein complex assembly, cerebrospinal fluid circulation, determination of left/right symmetry, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, heart development, intraciliary transport, outer dynein arm assembly, protein polyubiquitination; CC: SCF ubiquitin ligase complex, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, extracellular region, motile cilium
Pathways:
UniProt: D3Z7A5
Entrez ID: 71227
|
Does Knockout of Ptprn in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Ptprn
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Ptprn (protein tyrosine phosphatase receptor type N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: insulin secretion involved in cellular response to glucose stimulus, luteinization, positive regulation of transcription by RNA polymerase II, positive regulation of type B pancreatic cell proliferation, regulation of secretion, response to reactive oxygen species; MF: GTPase binding, protein binding, spectrin binding, ubiquitin-like protein ligase binding; CC: Golgi apparatus, axon, axon terminus, cell projection, cytoplasmic vesicle, endosome, membrane, neuronal cell body, neuronal dense core vesicle membrane, nucleus, perikaryon, plasma membrane, secretory granule, synapse, synaptic vesicle, transport vesicle membrane
Pathways: Type I diabetes mellitus - Mus musculus (mouse)
UniProt: A0A087WQF2, A6MDD2, A0A087WPU7, A0A087WQ67
Entrez ID: 19275
|
Does Knockout of Tex30 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Tex30
|
phagocytosis
|
macrophage
|
Gene: Tex30 (testis expressed 30)
Type: protein-coding
Summary: Is expressed in diencephalon lateral wall ventricular layer; midbrain ventricular layer; and telencephalon ventricular layer. Orthologous to human TEX30 (testis expressed 30). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q3TUU5
Entrez ID: 75623
|
Does Knockout of Dhx37 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Dhx37
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Dhx37 (DEAH-box helicase 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of male gonad development, ribosomal small subunit biogenesis, ribosome assembly, ribosome biogenesis; MF: ATP binding, RNA binding, U3 snoRNA binding, helicase activity, nucleic acid binding, nucleotide binding; CC: cytoplasm, nuclear membrane, nucleolus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: A0A0G2JG97, Q6NZL1, A0A0G2JG93
Entrez ID: 208144
|
Does Knockout of Slc22a26 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Slc22a26
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc22a26 (solute carrier family 22 (organic cation transporter), member 26)
Type: protein-coding
Summary: Predicted to enable short-chain fatty acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A25 (solute carrier family 22 member 25). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: organic anion transport, transmembrane transport; MF: organic anion transmembrane transporter activity, short-chain fatty acid transmembrane transporter activity, sodium-independent organic anion transmembrane transporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane
Pathways:
UniProt: E9Q6M5, Q91WJ2
Entrez ID: 236149
|
Does Knockout of Lipc in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Lipc
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Lipc (lipase, hepatic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, cholesterol metabolic process, cholesterol transport, chylomicron remnant clearance, chylomicron remodeling, fatty acid biosynthetic process, fatty acid metabolic process, glycerophospholipid catabolic process, heparan sulfate proteoglycan biosynthetic process, high-density lipoprotein particle remodeling, lipid catabolic process, lipid metabolic process, low-density lipoprotein particle clearance, low-density lipoprotein particle remodeling, neutral lipid catabolic process, phosphatidic acid metabolic process, phosphatidylcholine metabolic process, phosphatidylethanolamine metabolic process, phosphatidylserine metabolic process, regulation of plasma lipoprotein particle levels, triglyceride catabolic process, triglyceride homeostasis, triglyceride metabolic process, very-low-density lipoprotein particle remodeling; MF: acetylesterase activity, acyltransferase activity, apolipoprotein binding, carboxylic ester hydrolase activity, chylomicron binding, heparan sulfate proteoglycan binding, heparin binding, hydrolase activity, identical protein binding, lipase activity, lipid binding, lipoprotein lipase activity, low-density lipoprotein particle binding, monoacylglycerol lipase activity, phosphatidylcholine lysophospholipase activity, phospholipase A1 activity, triacylglycerol lipase activity; CC: cell surface, early endosome, extracellular region, extracellular space, high-density lipoprotein particle, late endosome, microvillus
Pathways: Assembly of active LPL and LIPC lipase complexes, Cholesterol metabolism - Mus musculus (mouse), Chylomicron clearance, Glycerolipid metabolism - Mus musculus (mouse), Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Plasma lipoprotein remodeling, Transport of small molecules, triacylglycerol degradation
UniProt: P27656
Entrez ID: 15450
|
Does Knockout of Usp48 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Usp48
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Usp48 (ubiquitin specific peptidase 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, peptidase activity; CC: cell projection, cilium, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, postsynaptic membrane
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q3V0C5
Entrez ID: 170707
|
Does Knockout of Pcca in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Pcca
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pcca (propionyl-Coenzyme A carboxylase, alpha polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid catabolic process, lipid metabolic process; MF: ATP binding, enzyme binding, ligase activity, metal ion binding, nucleotide binding, propionyl-CoA carboxylase activity; CC: catalytic complex, mitochondrial matrix, mitochondrion
Pathways: Biotin transport and metabolism, Fatty acid metabolism, Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Mitochondrial Fatty Acid Beta-Oxidation, Propanoate metabolism - Mus musculus (mouse), Propionyl-CoA catabolism, Valine, leucine and isoleucine degradation - Mus musculus (mouse), isoleucine degradation, methylmalonyl pathway, superpathway of methionine degradation, valine degradation
UniProt: Q91ZA3
Entrez ID: 110821
|
Does Knockout of Ube2z in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Ube2z
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Ube2z (ubiquitin-conjugating enzyme E2Z)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, positive regulation of apoptotic process, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, molecular adaptor activity, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q3UE37
Entrez ID: 268470
|
Does Knockout of Ucn in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,493
|
Knockout
|
Ucn
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ucn (urocortin)
Type: protein-coding
Summary: This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit a heightened anxiety-like behaviors and a significantly reduced acoustic startle response. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: aerobic respiration, associative learning, drinking behavior, feeding behavior, female pregnancy, learning or memory, negative regulation of apoptotic process, negative regulation of appetite, negative regulation of blood pressure, negative regulation of cell size, negative regulation of feeding behavior, negative regulation of gene expression, negative regulation of hormone secretion, negative regulation of neuron apoptotic process, neuron projection development, neuropeptide signaling pathway, positive regulation of DNA replication, positive regulation of behavioral fear response, positive regulation of cAMP/PKA signal transduction, positive regulation of calcium ion import, positive regulation of cardiac muscle contraction, positive regulation of cell growth, positive regulation of collagen biosynthetic process, positive regulation of corticotropin secretion, positive regulation of gene expression, positive regulation of interleukin-6 production, positive regulation of transcription by RNA polymerase II, positive regulation of translation, positive regulation of vascular permeability, prepulse inhibition, regulation of synaptic transmission, glutamatergic, response to auditory stimulus, response to estradiol, response to glucocorticoid, response to immobilization stress, response to oxidative stress, response to pain, response to starvation, sensory perception of sound, social behavior, startle response, vasodilation; MF: G protein-coupled receptor binding, corticotropin-releasing hormone receptor 1 binding, corticotropin-releasing hormone receptor 2 binding, histone deacetylase inhibitor activity, hormone activity; CC: axon, axon terminus, dendrite, extracellular region, neuronal cell body, perikaryon, varicosity
Pathways: Class B/2 (Secretin family receptors), GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P81615
Entrez ID: 22226
|
Does Knockout of Ndufc2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Ndufc2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ndufc2 (NADH:ubiquinone oxidoreductase subunit C2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of reactive oxygen species biosynthetic process, positive regulation of ATP biosynthetic process, positive regulation of mitochondrial membrane potential, proton motive force-driven mitochondrial ATP synthesis; CC: cytoplasm, membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Neutrophil degranulation, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQ54
Entrez ID: 68197
|
Does Knockout of Dnmt1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Dnmt1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Dnmt1 (DNA methyltransferase 1)
Type: protein-coding
Summary: This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-terminal domain with a nuclear localization sequence and replication fork-targeting domain, a DNA-binding CXXC domain, two bromo-adjacent homology domains, and a C-terminal catalytic domain. Mouse embryonic stem cells mutant for this gene are viable, but when introduced into the germ line, cause a recessive lethal phenotype with mutant embryos displaying stunted growth and developmental defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cellular response to amino acid stimulus, cellular response to bisphenol A, cellular response to transforming growth factor beta stimulus, chromatin organization, chromosomal DNA methylation maintenance following DNA replication, epigenetic programming of gene expression, methylation, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell apoptotic process, negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching, positive regulation of gene expression, positive regulation of vascular associated smooth muscle cell proliferation, regulation of cell population proliferation, regulation of gene expression, response to bisphenol A, response to xenobiotic stimulus; MF: DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates, DNA binding, DNA-methyltransferase activity, RNA binding, catalytic activity, chromatin binding, histone deacetylase binding, lncRNA binding, metal ion binding, methyl-CpG binding, methyltransferase activity, nuclear estrogen receptor binding, promoter-specific chromatin binding, protein binding, protein domain specific binding, transferase activity, zinc ion binding; CC: cytoplasm, female germ cell nucleus, germ cell nucleus, heterochromatin, nucleoplasm, nucleus, pericentric heterochromatin, protein-containing complex, replication fork
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Epigenetic regulation of gene expression, Gene expression (Transcription), Metabolism of proteins, MicroRNAs in cancer - Mus musculus (mouse), PRC2 methylates histones and DNA, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA methylation proteins
UniProt: P13864
Entrez ID: 13433
|
Does Knockout of Tnfaip8l3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Tnfaip8l3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tnfaip8l3 (tumor necrosis factor, alpha-induced protein 8-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process, intermembrane lipid transfer, lipid transport, phospholipid transport, positive regulation of ERK1 and ERK2 cascade, regulation of apoptotic process; MF: phosphatidylinositol binding, phosphatidylinositol transfer activity; CC: cytoplasm, cytosol, membrane, nucleoplasm, plasma membrane
Pathways: Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism
UniProt: Q3TBL6
Entrez ID: 244882
|
Does Knockout of Aadat in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Aadat
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Aadat (aminoadipate aminotransferase)
Type: protein-coding
Summary: Predicted to enable protein homodimerization activity and transaminase activity. Predicted to be involved in 2-oxoglutarate metabolic process; glutamate metabolic process; and kynurenine metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; heart; liver; and metanephros. Orthologous to human AADAT (aminoadipate aminotransferase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: 2-oxoglutarate metabolic process, L-lysine catabolic process to acetyl-CoA via saccharopine, alpha-amino acid metabolic process, glutamate metabolic process, kynurenine metabolic process; MF: 2-aminoadipate transaminase activity, glycine:2-oxoglutarate aminotransferase activity, kynurenine-glyoxylate transaminase activity, kynurenine-oxoglutarate transaminase activity, methionine-glyoxylate transaminase activity, protein homodimerization activity, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: Lysine catabolism, Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Tryptophan catabolism, Tryptophan metabolism - Mus musculus (mouse), lysine degradation II
UniProt: Q9WVM8
Entrez ID: 23923
|
Does Knockout of 5530400C23Rik in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
5530400C23Rik
|
cell proliferation
|
Melanoma Cell Line
|
Gene: 5530400C23Rik (RIKEN cDNA 5530400C23 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydroxyapatite binding, molecular_function; CC: cellular_component, extracellular region
Pathways:
UniProt: Q9D3I0
Entrez ID: 232426
|
Does Knockout of Izumo1r in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Izumo1r
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Izumo1r (IZUMO1 receptor, JUNO)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, fusion of sperm to egg plasma membrane involved in single fertilization, single fertilization, sperm-egg recognition; MF: folic acid binding, protein binding, signaling receptor activity, signaling receptor binding; CC: external side of plasma membrane, membrane, plasma membrane, side of membrane
Pathways: Endocytosis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q9EQF4
Entrez ID: 64931
|
Does Knockout of Ogfod3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Ogfod3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ogfod3 (2-oxoglutarate and iron-dependent oxygenase domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: L-ascorbic acid binding, dioxygenase activity, iron ion binding, metal ion binding, molecular_function, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Pathways:
UniProt: Q9D136
Entrez ID: 66179
|
Does Knockout of Adgrg3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Adgrg3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adgrg3 (adhesion G protein-coupled receptor G3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, negative regulation of CREB transcription factor activity, negative regulation of non-canonical NF-kappaB signal transduction, regulation of cell migration, signal transduction; MF: G protein-coupled receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q8R0T6
Entrez ID: 54672
|
Does Knockout of Camk2n1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Camk2n1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Camk2n1 (calcium/calmodulin-dependent protein kinase II inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: long-term memory, positive regulation of inflammatory response, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of systemic arterial blood pressure; MF: calcium-dependent protein kinase inhibitor activity, protein kinase binding, protein kinase inhibitor activity; CC: cell projection, dendrite, neuronal cell body, postsynaptic density, synapse
Pathways:
UniProt: Q6QWF9
Entrez ID: 66259
|
Does Knockout of Sys1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Sys1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sys1 (SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to endosome transport, Golgi to plasma membrane protein transport, protein localization to Golgi apparatus, protein transport; CC: Golgi apparatus, Golgi membrane, cytosol, membrane, trans-Golgi network
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q78S06
Entrez ID: 66460
|
Does Knockout of Recql in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Recql
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Recql (RecQ protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, DNA repair, DNA replication, double-strand break repair via homologous recombination, replication fork processing; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, DNA/DNA annealing activity, double-stranded DNA helicase activity, four-way junction helicase activity, helicase activity, hydrolase activity, isomerase activity, metal ion binding, nucleic acid binding, nucleotide binding; CC: chromosome, cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q9Z129
Entrez ID: 19691
|
Does Knockout of Tmem74 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Tmem74
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tmem74 (transmembrane protein 74)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, general adaptation syndrome, behavioral process, macroautophagy; CC: autophagosome membrane, cytoplasmic vesicle, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways:
UniProt: Q8BQU7
Entrez ID: 239408
|
Does Knockout of Golt1b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Golt1b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Golt1b (golgi transport 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated transport; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, membrane, protein-containing complex
Pathways:
UniProt: Q9CR60
Entrez ID: 66964
|
Does Knockout of Rnd3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Rnd3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rnd3 (Rho family GTPase 3)
Type: protein-coding
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and signal transduction. Predicted to be located in Golgi membrane. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; liver; and retina. Orthologous to human RND3 (Rho family GTPase 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: actin filament organization, regulation of actin cytoskeleton organization, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding; CC: Golgi apparatus, Golgi membrane, cytosol, membrane, plasma membrane
Pathways: RHO GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P61588
Entrez ID: 74194
|
Does Knockout of Ascc1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Ascc1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ascc1 (activating signal cointegrator 1 complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA alkylation repair, DNA damage response, DNA repair, regulation of DNA-templated transcription; MF: RNA binding, nucleic acid binding; CC: DNA repair complex, nuclear speck, nucleus, transcription regulator complex
Pathways:
UniProt: Q9D8Z1
Entrez ID: 69090
|
Does Knockout of Mmp16 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Mmp16
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mmp16 (matrix metallopeptidase 16)
Type: protein-coding
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit retarded growth of the skeleton, especially in the cranium and long bones. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: bone development, chondrocyte proliferation, collagen catabolic process, craniofacial suture morphogenesis, embryonic cranial skeleton morphogenesis, endochondral ossification, extracellular matrix organization, ossification, protein processing, proteolysis, skeletal system development; MF: hydrolase activity, metal ion binding, metalloaminopeptidase activity, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular space, membrane, plasma membrane
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, MicroRNAs in cancer - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Signal Transduction, Signaling by TGFB family members, Signaling by TGFBR3, TGFBR3 PTM regulation
UniProt: Q9WTR0
Entrez ID: 17389
|
Does Knockout of Pde6c in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Pde6c
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Pde6c (phosphodiesterase 6C, cGMP specific, cone, alpha prime)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cAMP/PKA signal transduction, phototransduction, visible light, retina development in camera-type eye, retinal cone cell development, sensory perception of light stimulus, signal transduction, visual perception; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cGMP binding, hydrolase activity, metal ion binding, nucleotide binding, phosphoric diester hydrolase activity; CC: membrane, plasma membrane
Pathways: Purine metabolism - Mus musculus (mouse), cyclic GMP biosynthesis
UniProt: Q91ZQ1
Entrez ID: 110855
|
Does Knockout of 1700019D03Rik in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
1700019D03Rik
|
cell cycle progression
|
breast epithelium
|
Gene: 1700019D03Rik (RIKEN cDNA 1700019D03 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein kinase A regulatory subunit binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9CPS8
Entrez ID: 67080
|
Does Knockout of Xlr3b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Xlr3b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Xlr3b (X-linked lymphocyte-regulated 3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, positive regulation of dendritic spine morphogenesis, positive regulation of synapse assembly, spermatid development
Pathways:
UniProt: Q6P205
Entrez ID: 574437
|
Does Knockout of Bambi in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Bambi
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bambi (BMP and activin membrane-bound inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, negative regulation of BMP signaling pathway, negative regulation of osteoblast differentiation, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of DNA-templated transcription, positive regulation of canonical Wnt signaling pathway, positive regulation of cell population proliferation, positive regulation of epithelial to mesenchymal transition, regulation of cell shape, transforming growth factor beta receptor signaling pathway; MF: frizzled binding; CC: cytoplasm, membrane, plasma membrane
Pathways: Downregulation of TGF-beta receptor signaling, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, TGF-beta signaling pathway - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q9D0L6
Entrez ID: 68010
|
Does Knockout of Zdhhc20 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Zdhhc20
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Zdhhc20 (zinc finger, DHHC domain containing 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: host-mediated activation of viral process, peptidyl-L-cysteine S-palmitoylation, protein palmitoylation, protein targeting to membrane, synaptic vesicle maturation, virion attachment to host cell; MF: acyltransferase activity, metal ion binding, palmitoyltransferase activity, protein-cysteine S-myristoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, protein-cysteine S-stearoyltransferase activity, transferase activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q5Y5T1
Entrez ID: 75965
|
Does Knockout of Pola1 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,528
|
Knockout
|
Pola1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Pola1 (polymerase (DNA directed), alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA repair, DNA replication, DNA replication initiation, DNA replication, synthesis of primer, DNA strand elongation involved in DNA replication, DNA synthesis involved in DNA repair, DNA synthesis involved in UV-damage excision repair, double-strand break repair via nonhomologous end joining, lagging strand elongation, leading strand elongation, mitotic DNA replication initiation, regulation of type I interferon production; MF: DNA binding, DNA polymerase activity, DNA replication origin binding, DNA-directed DNA polymerase activity, chromatin binding, double-stranded DNA binding, metal ion binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, protein binding, protein kinase binding, purine nucleotide binding, pyrimidine nucleotide binding, single-stranded DNA binding, transferase activity, zinc ion binding; CC: alpha DNA polymerase:primase complex, chromatin, cytoplasm, cytosol, nuclear envelope, nuclear matrix, nucleolus, nucleoplasm, nucleus
Pathways: Activation of the pre-replicative complex, Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), DNA replication initiation, DNA strand elongation, E2F mediated regulation of DNA replication, Extension of Telomeres, G1/S Transition, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Lagging Strand Synthesis, Leading Strand Synthesis, Mitotic G1 phase and G1/S transition, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the lagging strand, Removal of the Flap Intermediate, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: P33609
Entrez ID: 18968
|
Does Knockout of Mip in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Mip
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mip (major intrinsic protein of lens fiber)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canalicular bile acid transport, cell communication, gap junction-mediated intercellular transport, homotypic cell-cell adhesion, lens development in camera-type eye, maintenance of lens transparency, transmembrane transport, visual perception, water transport; MF: calmodulin binding, cell adhesion mediator activity, channel activity, protein binding, structural constituent of eye lens, water channel activity; CC: anchoring junction, apical plasma membrane, intracellular canaliculus, membrane, plasma membrane
Pathways: Aquaporin-mediated transport, Passive transport by Aquaporins, Transport of small molecules
UniProt: P51180
Entrez ID: 17339
|
Does Knockout of 1700030K09Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
1700030K09Rik
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: 1700030K09Rik (RIKEN cDNA 1700030K09 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q922C1
Entrez ID: 72254
|
Does Knockout of Krt42 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Krt42
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Krt42 (keratin 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium; MF: structural constituent of skin epidermis, structural molecule activity; CC: cytoplasm, cytoskeleton, intermediate filament, keratin filament
Pathways: Estrogen signaling pathway - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Q6IFX2
Entrez ID: 68239
|
Does Knockout of Efemp2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Efemp2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Efemp2 (epidermal growth factor-containing fibulin-like extracellular matrix protein 2)
Type: protein-coding
Summary: Predicted to enable heparin binding activity and protein homodimerization activity. Involved in several processes, including elastic fiber assembly; negative regulation of vascular associated smooth muscle cell proliferation; and vasculature development. Acts upstream of or within artery development. Located in basement membrane; elastic fiber; and microfibril. Is expressed in several structures, including central nervous system; genitourinary system; gut; immune system; and respiratory system. Used to study aortic aneurysm and cutis laxa. Human ortholog(s) of this gene implicated in aortic aneurysm; arterial tortuosity syndrome; autosomal recessive cutis laxa type IB; endometrial cancer; and osteosarcoma. Orthologous to human EFEMP2 (EGF containing fibulin extracellular matrix protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: aorta development, aorta smooth muscle tissue morphogenesis, artery development, elastic fiber assembly, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of aortic smooth muscle cell differentiation, positive regulation of collagen fibril organization, positive regulation of smooth muscle cell-matrix adhesion, regulation of collagen fibril organization, vascular associated smooth muscle cell development; MF: calcium ion binding, extracellular matrix constituent conferring elasticity, heparin binding, protein binding, protein homodimerization activity; CC: basement membrane, elastic fiber, extracellular matrix, extracellular region, extracellular space, microfibril
Pathways: Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres
UniProt: Q9WVJ9
Entrez ID: 58859
|
Does Knockout of Zfand4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Zfand4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfand4 (zinc finger, AN1-type domain 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: D3Z3C6
Entrez ID: 67492
|
Does Knockout of Rabep1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Rabep1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rabep1 (rabaptin, RAB GTPase binding effector protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, apoptotic process, endocytosis, protein localization to ciliary membrane, protein transport, regulation of postsynaptic neurotransmitter receptor internalization, signal transduction, vesicle-mediated transport; MF: GTPase activator activity, growth factor activity, protein binding, protein domain specific binding, protein homodimerization activity; CC: cytoplasm, cytoplasmic vesicle, cytosol, early endosome, endocytic vesicle, endosome, glutamatergic synapse, presynaptic cytosol, protein-containing complex, recycling endosome
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: O35551
Entrez ID: 54189
|
Does Knockout of Mycbpap in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Mycbpap
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Mycbpap (MYCBP associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, chemical synaptic transmission, spermatogenesis; CC: cytoplasm, membrane, synapse
Pathways:
UniProt: Q5SUV2
Entrez ID: 104601
|
Does Knockout of Itga7 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Itga7
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Itga7 (integrin alpha 7)
Type: protein-coding
Summary: This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded transmembrane protein is the alpha subunit that forms a noncovalent heterodimer with the beta subunit to form the functional integrin receptor that binds to laminin. Mice lacking the encoded protein exhibit symptoms of progressive muscular dystrophy, impaired axonal regeneration and cerebral vascular defects. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: blood vessel morphogenesis, cell adhesion, cell migration, cell-cell adhesion, cell-matrix adhesion, heterotypic cell-cell adhesion, integrin-mediated signaling pathway, leukocyte migration, regulation of cell shape; MF: cell adhesion molecule binding, integrin binding, laminin binding, metal ion binding, protein binding, protein-containing complex binding, signaling receptor activity; CC: cell surface, cytoplasm, integrin alpha7-beta1 complex, integrin complex, membrane, muscle tendon junction, neuromuscular junction, sarcolemma
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), ECM-receptor interaction - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse)
UniProt: G3X9Q1, Q3TZS3, A0A8V5L190, A0A1W2P7M9
Entrez ID: 16404
|
Does Knockout of Prkacb in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Prkacb
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Prkacb (protein kinase, cAMP dependent, catalytic, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cellular response to nutrient levels, dorsal/ventral neural tube patterning, negative regulation of TORC1 signaling, negative regulation of meiotic cell cycle, negative regulation of smoothened signaling pathway, neural tube closure, protein phosphorylation, regulation of protein processing; MF: ATP binding, cAMP-dependent protein kinase activity, kinase activity, magnesium ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin protein ligase binding; CC: cAMP-dependent protein kinase complex, centrosome, ciliary base, cytoplasm, cytosol, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Activation of NMDA receptors and postsynaptic events, Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Aquaporin-mediated transport, Autophagy - animal - Mus musculus (mouse), Axon guidance, Bile secretion - Mus musculus (mouse), C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, CREB1 phosphorylation through the activation of Adenylate Cyclase, Ca-dependent events, CaM pathway, Calcium signaling pathway - Mus musculus (mouse), Calmodulin induced events, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), DAG and IP3 signaling, DARPP-32 events, Developmental Biology, Dilated cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Factors involved in megakaryocyte development and platelet production, G alpha (i) signalling events, G alpha (s) signalling events, G-protein mediated events, GABAergic synapse - Mus musculus (mouse), GLI3 is processed to GLI3R by the proteasome, GPCR downstream signalling, GPER1 signaling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glucagon signaling in metabolic regulation, Glucagon signaling pathway - Mus musculus (mouse), Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glutamatergic synapse - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HDL assembly, Hedgehog 'off' state, Hedgehog signaling pathway - Mus musculus (mouse), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Innate Immune System, Insulin secretion - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Integration of energy metabolism, Intracellular signaling by second messengers, Long-term potentiation - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK6/MAPK4 signaling, Melanogenesis - Mus musculus (mouse), Metabolism, Morphine addiction - Mus musculus (mouse), Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Olfactory transduction - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Opioid Signalling, Ovarian steroidogenesis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PKA activation, PKA activation in glucagon signalling, PKA-mediated phosphorylation of CREB, PLC beta mediated events, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Platelet activation - Mus musculus (mouse), Post NMDA receptor activation events, Prion disease - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RET signaling, Rap1 signalling, Ras signaling pathway - Mus musculus (mouse), Regulation of insulin secretion, Regulation of lipolysis in adipocytes - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Signaling by Hedgehog, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Taste transduction - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules, VEGFA-VEGFR2 Pathway, Vascular smooth muscle contraction - Mus musculus (mouse), Vasopressin regulates renal water homeostasis via Aquaporins, Vasopressin-regulated water reabsorption - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: P68181
Entrez ID: 18749
|
Does Knockout of Dhdh in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Dhdh
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Dhdh (dihydrodiol dehydrogenase)
Type: protein-coding
Summary: Enables D-xylose 1-dehydrogenase (NADP+) activity. Acts upstream of or within D-xylose catabolic process. Is expressed in nervous system and respiratory system. Orthologous to human DHDH (dihydrodiol dehydrogenase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: D-xylose catabolic process; MF: D-xylose 1-dehydrogenase (NADP+) activity, nucleotide binding, oxidoreductase activity, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Pathways: Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pentose and glucuronate interconversions - Mus musculus (mouse)
UniProt: Q9DBB8
Entrez ID: 71755
|
Does Knockout of Ccdc82 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Ccdc82
|
cell proliferation
|
Regulatory T cell
|
Gene: Ccdc82 (coiled-coil domain containing 82)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6PG04
Entrez ID: 66396
|
Does Knockout of Amz2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Amz2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Amz2 (archaelysin family metallopeptidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity
Pathways:
UniProt: Q400C8
Entrez ID: 13929
|
Does Knockout of Gm10330 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm10330
|
phagocytosis
|
macrophage
|
Gene: Gm10330 (predicted gene 10330)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Crxos in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Crxos
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Crxos (cone-rod homeobox, opposite strand)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst hatching, embryonic placenta development, positive regulation of stem cell differentiation, regulation of transcription by RNA polymerase II, stem cell population maintenance; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific; CC: nucleus
Pathways:
UniProt: Q3UL53
Entrez ID: 546024
|
Does Knockout of Gm10638 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Gm10638
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gm10638 (predicted gene 10638)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Zfp708 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Zfp708
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zfp708 (zinc finger protein 708)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transposable element silencing; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: A0A087WPV0, F2Z422, F8VPP0
Entrez ID: 432769
|
Does Knockout of Mir495 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mir495
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mir495 (microRNA 495)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cellular response to mechanical stimulus, cellular response to phenylalanine, energy homeostasis, miRNA-mediated post-transcriptional gene silencing
Pathways:
UniProt:
Entrez ID: 751522
|
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