prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Wasf3 in Embryonic Cell Line causally result in protein/peptide accumulation? | 1 | 1,152 | Knockout | Wasf3 | protein/peptide accumulation | Embryonic Cell Line | Gene: Wasf3 (WASP family, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, cytoskeleton organization, lamellipodium assembly, lamellipodium organization, modification of postsynaptic actin cytoskeleton, oligodendrocyte development... |
Does Knockout of Snap91 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Snap91 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Snap91 (synaptosomal-associated protein 91)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, chemical synaptic transmission, clathrin coat assembly, clathrin-dependent endocytosis, establishment or maintenance of cell polarity, neuron development, neuro... |
Does Knockout of Cmtm4 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Cmtm4 | response to chemicals | pro-B-lymphocyte | Gene: Cmtm4 (CKLF-like MARVEL transmembrane domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane
Pathways:
UniProt: Q8CJ61
Entrez ID: 97487 |
Does Knockout of Cep152 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Cep152 | protein/peptide accumulation | Regulatory T cell | Gene: Cep152 (centrosomal protein 152)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, centriole replication, centrosome duplication, de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; MF: protein binding, ... |
Does Knockout of Col10a1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,172 | Knockout | Col10a1 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Col10a1 (collagen, type X, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone development, cartilage development, endochondral ossification; MF: extracellular matrix structural constituent conferring tensile strength, metal ion binding; CC: cell cortex, c... |
Does Knockout of Fam151b in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Fam151b | cell proliferation | Embryonic Stem Cell Line | Gene: Fam151b (family with sequence similarity 151, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, photoreceptor cell development
Pathways:
UniProt: D3YUE4
Entrez ID: 73942 |
Does Knockout of Suclg1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Suclg1 | cell proliferation | Colonic Cancer Cell Line | Gene: Suclg1 (succinate-CoA ligase, GDP-forming, alpha subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: succinate metabolic process, succinyl-CoA metabolic process, tricarboxylic acid cycle; MF: GDP binding, catalytic activity, ligase activity, nucleotide binding,... |
Does Knockout of Rln1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Rln1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Rln1 (relaxin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenylate cyclase-modulating G protein-coupled receptor signaling pathway, developmental growth, mammary gland morphogenesis, negative regulation of apoptotic process, nipple development, prostate glan... |
Does Knockout of Urm1 in Microglial Cell Line causally result in response to virus? | 0 | 1,438 | Knockout | Urm1 | response to virus | Microglial Cell Line | Gene: Urm1 (ubiquitin related modifier 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble uridine modification; MF: protein tag activity, sulfur carrier activity; CC: cytoplasm, cytosol, nucleus
... |
Does Knockout of Pik3r1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 1,664 | Knockout | Pik3r1 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, T follicular helper cell differentiation, cellular response to UV, cellular response to insulin stimulus, cytokine-mediated signaling path... |
Does Knockout of Zfp746 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,682 | Knockout | Zfp746 | protein/peptide distribution | myoblast cell line | Gene: Zfp746 (zinc finger protein 746)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, protein heteroo... |
Does Knockout of Zmym2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Zmym2 | cell proliferation | Melanoma Cell Line | Gene: Zmym2 (zinc finger, MYM-type 2)
Type: protein-coding
Summary: This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transformi... |
Does Knockout of Suz12 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Suz12 | protein/peptide accumulation | Embryonic Cell Line | Gene: Suz12 (SUZ12 polycomb repressive complex 2 subunit)
Type: protein-coding
Summary: This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through t... |
Does Knockout of Mtmr12 in Microglial Cell Line causally result in phagocytosis? | 0 | 1,587 | Knockout | Mtmr12 | phagocytosis | Microglial Cell Line | Gene: Mtmr12 (myotubularin related protein 12)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in sarcomere and sarcoplasmic reticulum. Predicted to be act... |
Does Knockout of Cfap20 in Melanoma Cell Line causally result in cell proliferation? | 1 | 1,270 | Knockout | Cfap20 | cell proliferation | Melanoma Cell Line | Gene: Cfap20 (cilia and flagella associated protein 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, flagellated sperm motility, positive regulation of cell motility, positive regulation of feeding behavior, protein polyglutamylation, regulation of cil... |
Does Knockout of Spr in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Spr | cell proliferation | Embryonic Stem Cell Line | Gene: Spr (sepiapterin reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-phenylalanine metabolic process, cell morphogenesis involved in neuron differentiation, dopamine metabolic process, nitric oxide biosynthetic process, norepinephrine metabolic process, pte... |
Does Knockout of Esx1 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Esx1 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Esx1 (extraembryonic, spermatogenesis, homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel development, labyrinthine layer blood vessel development, labyrinthine layer morphogenesis, negative regulation of DNA-templated transcription, negative r... |
Does Knockout of Tas2r120 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Tas2r120 | protein/peptide accumulation | Microglial Cell Line | Gene: Tas2r120 (taste receptor, type 2, member 120)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sens... |
Does Knockout of Sec61g in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Sec61g | protein/peptide accumulation | Embryonic Cell Line | Gene: Sec61g (SEC61 translocon subunit gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, post-translational protein targeting to membrane, translocation, protein targeting, protein transport; MF: protein transmembrane transporter acti... |
Does Knockout of Jrk in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Jrk | protein/peptide accumulation | Mouse cell | Gene: Jrk (jerky)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of canonical Wnt signaling pathway; MF: DNA binding, mRNA binding, nucleic acid binding; CC: cytoplasm, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q60976
... |
Does Knockout of Ndufaf2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Ndufaf2 | cell proliferation | Melanoma Cell Line | Gene: Ndufaf2 (NADH:ubiquinone oxidoreductase complex assembly factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, mitochondrial respiratory chain complex I assembly, negative regulation of insulin secretion involved in... |
Does Knockout of Rdh16 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Rdh16 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Rdh16 (retinol dehydrogenase 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 9-cis-retinoic acid biosynthetic process, androgen biosynthetic process, lipid metabolic process, positive regulation of retinoic acid biosynthetic process, retinoic acid metabolic proc... |
Does Knockout of Tlr13 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Tlr13 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Tlr13 (toll-like receptor 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MyD88-dependent toll-like receptor signaling pathway, immune system process, inflammatory response, innate immune response, regulation of MAPK cascade, response to virus, signal transducti... |
Does Knockout of Tmem132b in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Tmem132b | response to bacteria | renal medulla cell line | Gene: Tmem132b (transmembrane protein 132B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: V9GX71, F7BAB2
Entrez ID: 208151 |
Does Knockout of Arpp19 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Arpp19 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Arpp19 (cAMP-regulated phosphoprotein 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, cell division, mitotic cell cycle, positive regulation of gluconeogenesis; MF: phosphatase inhibitor activity, potassium channel regulato... |
Does Knockout of Mdfi in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Mdfi | cell proliferation | Mouse kidney carcinoma cell | Gene: Mdfi (MyoD family inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, dorsal/ventral axis specification, embryonic skeletal system morphogenesis, maintenance of protein location in cell, negative regulation of DNA-templated transcription... |
Does Knockout of Pdlim3 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Pdlim3 | cell proliferation | Embryonic Stem Cell Line | Gene: Pdlim3 (PDZ and LIM domain 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament organization, heart development, muscle structure development; MF: actin binding, actinin binding, cytoskeletal protein binding, metal ion b... |
Does Knockout of D130052B06Rik in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,260 | Knockout | D130052B06Rik | cell proliferation | Mouse kidney carcinoma cell | Gene: D130052B06Rik (RIKEN cDNA D130052B06 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Insl3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,175 | Knockout | Insl3 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Insl3 (insulin-like 3)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor binding activity and protease binding activity. Involved in regulation of male gonad development. Acts upstream of or within in utero embryonic development and male gonad development. Predicted to b... |
Does Knockout of Klra9 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Klra9 | response to virus | Microglial Cell Line | Gene: Klra9 (killer cell lectin-like receptor subfamily A, member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, signaling receptor activity; CC: cell surface, membrane, plasma membrane
Pathways: Natural killer cell mediated cytotoxicity... |
Does Knockout of Adamts2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Adamts2 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Adamts2 (ADAM metallopeptidase with thrombospondin type 1 motif 2)
Type: protein-coding
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The enco... |
Does Knockout of Sptbn2 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Sptbn2 | protein/peptide accumulation | Embryonic Cell Line | Gene: Sptbn2 (spectrin beta, non-erythrocytic 2)
Type: protein-coding
Summary: A structural constituent of postsynapse. Involved in postsynapse organization and regulation of postsynaptic specialization assembly. Acts upstream of or within adult behavior; cerebellar Purkinje cell layer morphogenesis; an... |
Does Knockout of Cacna2d2 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Cacna2d2 | protein/peptide distribution | myoblast cell line | Gene: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, muscle cell developme... |
Does Knockout of Tufm in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Tufm | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Tufm (Tu translation elongation factor, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translational elongation, translation, translational elongation; MF: GTP binding, GTPase activity, hydrolase activity, magnesium ion binding, metal i... |
Does Knockout of Aadacl4 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Aadacl4 | cell proliferation | Mouse kidney carcinoma cell | Gene: Aadacl4 (arylacetamide deacetylase like 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: B1AVU5
Entrez ID: 435815 |
Does Knockout of Cngb1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Cngb1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Cngb1 (cyclic nucleotide gated channel beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium ion transmembrane transport, calcium ion transport, detection of chemical stimulus involved in sensory perception of ... |
Does Knockout of Ctso in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Ctso | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Ctso (cathepsin O)
Type: protein-coding
Summary: This gene encodes a member of the cathepsin family of cysteine proteases that are involved in the degradation of cellular proteins. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme. [provided by RefS... |
Does Knockout of Aacs in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Aacs | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Aacs (acetoacetyl-CoA synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to glucose stimulus, fatty acid metabolic process, lipid metabolic process, liver development, positive regulation of insulin secretion, response to ethanol, response... |
Does Knockout of Usp28 in Pancreatic Cell Line causally result in protein/peptide accumulation? | 0 | 2,196 | Knockout | Usp28 | protein/peptide accumulation | Pancreatic Cell Line | Gene: Usp28 (ubiquitin specific peptidase 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, cell population proliferation, cellular response to UV, intrinsic apoptotic signaling pathway in response to DNA... |
Does Knockout of Ak6 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Ak6 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Ak6 (adenylate kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleoside monophosphate phosphorylation, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: AMP kinase activity, ATP binding, ATP hydrolysis activity, kinase activit... |
Does Knockout of Mbl2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Mbl2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Mbl2 (mannose-binding lectin (protein C) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of membrane attack complex, antiviral innate immune response, cell surface pattern recognition receptor signaling pathway, complement activation, complement activa... |
Does Knockout of Otop2 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Otop2 | response to virus | Neuroblastoma Cell Line | Gene: Otop2 (otopetrin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, proton transmembrane transport; MF: proton channel activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q80... |
Does Knockout of Sdccag8 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Sdccag8 | protein/peptide accumulation | Regulatory T cell | Gene: Sdccag8 (serologically defined colon cancer antigen 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, centrosome cycle, establishment of cell polarity, microtubule organizing center organization, neuron migration, regulation of cilium ... |
Does Knockout of Acvr1b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Acvr1b | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Acvr1b (activin A receptor, type 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, activin receptor signaling pathway, cardiac fibroblast cell development, cell surface receptor protein serine/threonine kinase signaling pathw... |
Does Knockout of Snhg11 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Snhg11 | cell proliferation | Mouse kidney carcinoma cell | Gene: Snhg11 (small nucleolar RNA host gene 11)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 319317 |
Does Knockout of Ankrd60 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Ankrd60 | cell proliferation | Colonic Cancer Cell Line | Gene: Ankrd60 (ankyrin repeat domain 60)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A2AMD2, A0A6I8MWY2, A6PWV4
Entrez ID: 70065 |
Does Knockout of Tmem87b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Tmem87b | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Tmem87b (transmembrane protein 87B)
Type: protein-coding
Summary: Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in Golgi cisterna membrane. Is expressed in medulla oblongata; medulla oblongata basa... |
Does Knockout of Slco4a1 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Slco4a1 | protein/peptide accumulation | Regulatory T cell | Gene: Slco4a1 (solute carrier organic anion transporter family, member 4a1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, organic anion transport, prostaglandin transport, sodium-independent organic anion transport, thyroid hormone metabolic pr... |
Does Knockout of Ccr6 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Ccr6 | cell proliferation | Colonic Cancer Cell Line | Gene: Ccr6 (C-C motif chemokine receptor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DN2 thymocyte differentiation, DN3 thymocyte differentiation, G protein-coupled receptor signaling pathway, T cell migration, calcium-mediated signaling, cell chemotaxis, chemokine... |
Does Knockout of Cox8c in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Cox8c | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Cox8c (cytochrome c oxidase subunit 8C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex IV
... |
Does Knockout of Smad9 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Smad9 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Smad9 (SMAD family member 9)
Type: protein-coding
Summary: This gene encodes a member of a family of proteins that act as downstream effectors of the bone morphogenetic protein (BMP) signaling pathway. The encoded protein is phosphorylated by BMP receptors, which stimulates its binding to SMAD4 an... |
Does Knockout of Daw1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Daw1 | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Daw1 (dynein assembly factor with WDR repeat domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonemal dynein complex assembly, cerebrospinal fluid circulation, determination of left/right symmetry, epithelial cilium movement involved in extracellular flui... |
Does Knockout of Ptprn in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,180 | Knockout | Ptprn | tumorigenicity | Colonic Cancer Cell Line | Gene: Ptprn (protein tyrosine phosphatase receptor type N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: insulin secretion involved in cellular response to glucose stimulus, luteinization, positive regulation of transcription by RNA polymerase II, positive regulation of... |
Does Knockout of Tex30 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Tex30 | phagocytosis | macrophage | Gene: Tex30 (testis expressed 30)
Type: protein-coding
Summary: Is expressed in diencephalon lateral wall ventricular layer; midbrain ventricular layer; and telencephalon ventricular layer. Orthologous to human TEX30 (testis expressed 30). [provided by Alliance of Genome Resources, Jul 2025]
Ge... |
Does Knockout of Dhx37 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,178 | Knockout | Dhx37 | tumorigenicity | Colonic Cancer Cell Line | Gene: Dhx37 (DEAH-box helicase 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of male gonad development, ribosomal small subunit biogenesi... |
Does Knockout of Slc22a26 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Slc22a26 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Slc22a26 (solute carrier family 22 (organic cation transporter), member 26)
Type: protein-coding
Summary: Predicted to enable short-chain fatty acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion... |
Does Knockout of Lipc in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Lipc | cell proliferation | Colonic Cancer Cell Line | Gene: Lipc (lipase, hepatic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, cholesterol metabolic process, cholesterol transport, chylomicron remnant clearance, chylomicron remodeling, fatty acid biosynthetic process, fatty acid metabolic process... |
Does Knockout of Usp48 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Usp48 | protein/peptide distribution | myoblast cell line | Gene: Usp48 (ubiquitin specific peptidase 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase a... |
Does Knockout of Pcca in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Pcca | cell proliferation | Embryonic Stem Cell Line | Gene: Pcca (propionyl-Coenzyme A carboxylase, alpha polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid catabolic process, lipid metabolic process; MF: ATP binding, enzyme binding, ligase activity, metal ion binding, nucleotide binding, propionyl-CoA carbox... |
Does Knockout of Ube2z in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Ube2z | response to chemicals | pro-B-lymphocyte | Gene: Ube2z (ubiquitin-conjugating enzyme E2Z)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, positive regulation of apoptotic process, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF:... |
Does Knockout of Ucn in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,493 | Knockout | Ucn | cell proliferation | Melanoma Cell Line | Gene: Ucn (urocortin)
Type: protein-coding
Summary: This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature... |
Does Knockout of Ndufc2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Ndufc2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ndufc2 (NADH:ubiquinone oxidoreductase subunit C2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, negative regulation of non-canonical NF-... |
Does Knockout of Dnmt1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,174 | Knockout | Dnmt1 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Dnmt1 (DNA methyltransferase 1)
Type: protein-coding
Summary: This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This enzyme plays roles in diverse cellular process... |
Does Knockout of Tnfaip8l3 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Tnfaip8l3 | cell proliferation | Mouse kidney carcinoma cell | Gene: Tnfaip8l3 (tumor necrosis factor, alpha-induced protein 8-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process, intermembrane lipid transfer, lipid transport, phospholipid transport, positive regul... |
Does Knockout of Aadat in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Aadat | cell proliferation | Mouse kidney carcinoma cell | Gene: Aadat (aminoadipate aminotransferase)
Type: protein-coding
Summary: Predicted to enable protein homodimerization activity and transaminase activity. Predicted to be involved in 2-oxoglutarate metabolic process; glutamate metabolic process; and kynurenine metabolic process. Located in mitochondrion... |
Does Knockout of 5530400C23Rik in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | 5530400C23Rik | cell proliferation | Melanoma Cell Line | Gene: 5530400C23Rik (RIKEN cDNA 5530400C23 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydroxyapatite binding, molecular_function; CC: cellular_component, extracellular region
Pathways:
UniProt: Q9D3I0
Entrez ID: 232426 |
Does Knockout of Izumo1r in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Izumo1r | cell proliferation | Colonic Cancer Cell Line | Gene: Izumo1r (IZUMO1 receptor, JUNO)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, fusion of sperm to egg plasma membrane involved in single fertilization, single fertilization, sperm-egg recognition; MF: folic acid binding, protein binding, signaling re... |
Does Knockout of Ogfod3 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Ogfod3 | cell proliferation | Embryonic Stem Cell Line | Gene: Ogfod3 (2-oxoglutarate and iron-dependent oxygenase domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: L-ascorbic acid binding, dioxygenase activity, iron ion binding, metal ion binding, molecular_function, oxidoreductase activity, oxidoreductase a... |
Does Knockout of Adgrg3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Adgrg3 | protein/peptide distribution | myoblast cell line | Gene: Adgrg3 (adhesion G protein-coupled receptor G3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cell surface receptor sig... |
Does Knockout of Camk2n1 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,181 | Knockout | Camk2n1 | tumorigenicity | Colonic Cancer Cell Line | Gene: Camk2n1 (calcium/calmodulin-dependent protein kinase II inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: long-term memory, positive regulation of inflammatory response, positive regulation of insulin secretion involved in cellular response to glucose sti... |
Does Knockout of Sys1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Sys1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Sys1 (SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to endosome transport, Golgi to plasma membrane protein transport, protein localization to Golgi apparatus, protein transport; CC: Gol... |
Does Knockout of Recql in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Recql | protein/peptide accumulation | Embryonic Cell Line | Gene: Recql (RecQ protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, DNA repair, DNA replication, double-strand break repair via homologous recombination, replication fork processing; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolys... |
Does Knockout of Tmem74 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Tmem74 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Tmem74 (transmembrane protein 74)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, general adaptation syndrome, behavioral process, macroautophagy; CC: autophagosome membrane, cytoplasmic vesicle, lysosomal membrane, lysosome, membrane, plasma membrane
... |
Does Knockout of Golt1b in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Golt1b | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Golt1b (golgi transport 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated transport; CC: Golgi apparatus, Golgi membrane, cytopl... |
Does Knockout of Rnd3 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Rnd3 | cell proliferation | Embryonic Stem Cell Line | Gene: Rnd3 (Rho family GTPase 3)
Type: protein-coding
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and signal transduction. Predicted to be ... |
Does Knockout of Ascc1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Ascc1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Ascc1 (activating signal cointegrator 1 complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA alkylation repair, DNA damage response, DNA repair, regulation of DNA-templated transcription; MF: RNA binding, nucleic acid binding; CC: DNA repair comple... |
Does Knockout of Mmp16 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | Mmp16 | protein/peptide distribution | myoblast cell line | Gene: Mmp16 (matrix metallopeptidase 16)
Type: protein-coding
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded prepropr... |
Does Knockout of Pde6c in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Pde6c | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Pde6c (phosphodiesterase 6C, cGMP specific, cone, alpha prime)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cAMP/PKA signal transduction, phototransduction, visible light, retina development in camera-type eye, retinal cone cell development... |
Does Knockout of 1700019D03Rik in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | 1700019D03Rik | cell cycle progression | breast epithelium | Gene: 1700019D03Rik (RIKEN cDNA 1700019D03 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein kinase A regulatory subunit binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9CPS8
Entrez ID: 67080 |
Does Knockout of Xlr3b in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Xlr3b | cell proliferation | Embryonic Stem Cell Line | Gene: Xlr3b (X-linked lymphocyte-regulated 3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, positive regulation of dendritic spine morphogenesis, positive regulation of synapse assembly, spermatid development
Pathways:
UniProt: Q6... |
Does Knockout of Bambi in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Bambi | cell proliferation | Mouse kidney carcinoma cell | Gene: Bambi (BMP and activin membrane-bound inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, negative regulation of BMP signaling pathway, negative regulation of osteoblast differentiation, negative regulation of transforming growth factor beta r... |
Does Knockout of Zdhhc20 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Zdhhc20 | cell viability | Immortal mouse chromaffin cells | Gene: Zdhhc20 (zinc finger, DHHC domain containing 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: host-mediated activation of viral process, peptidyl-L-cysteine S-palmitoylation, protein palmitoylation, protein targeting to membrane, synaptic vesicle maturation, viri... |
Does Knockout of Pola1 in Lymphoma Cell Line causally result in response to chemicals? | 1 | 1,528 | Knockout | Pola1 | response to chemicals | Lymphoma Cell Line | Gene: Pola1 (polymerase (DNA directed), alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA repair, DNA replication, DNA replication initiation, DNA replication, synthesis of primer, DNA strand elongation involved in DNA replication, DNA... |
Does Knockout of Mip in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Mip | cell proliferation | Embryonic Stem Cell Line | Gene: Mip (major intrinsic protein of lens fiber)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canalicular bile acid transport, cell communication, gap junction-mediated intercellular transport, homotypic cell-cell adhesion, lens development in camera-type eye, mainten... |
Does Knockout of 1700030K09Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | 1700030K09Rik | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: 1700030K09Rik (RIKEN cDNA 1700030K09 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q922C1
Entrez ID: 72254 |
Does Knockout of Krt42 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Krt42 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Krt42 (keratin 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium; MF: structural constituent of skin epidermis, structural molecule activity; CC: cytoplasm, cytoske... |
Does Knockout of Efemp2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Efemp2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Efemp2 (epidermal growth factor-containing fibulin-like extracellular matrix protein 2)
Type: protein-coding
Summary: Predicted to enable heparin binding activity and protein homodimerization activity. Involved in several processes, including elastic fiber assembly; negative regulation of vascular... |
Does Knockout of Zfand4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Zfand4 | protein/peptide distribution | myoblast cell line | Gene: Zfand4 (zinc finger, AN1-type domain 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: D3Z3C6
Entrez ID: 67492 |
Does Knockout of Rabep1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,179 | Knockout | Rabep1 | cell proliferation | Colonic Cancer Cell Line | Gene: Rabep1 (rabaptin, RAB GTPase binding effector protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, apoptotic process, endocytosis, protein localization to ciliary membrane, protein transport, regulation of postsynaptic neuro... |
Does Knockout of Mycbpap in Embryonic Fibroblast Cell Line causally result in autophagy? | 1 | 1,044 | Knockout | Mycbpap | autophagy | Embryonic Fibroblast Cell Line | Gene: Mycbpap (MYCBP associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, chemical synaptic transmission, spermatogenesis; CC: cytoplasm, membrane, synapse
Pathways:
UniProt: Q5SUV2
Entrez... |
Does Knockout of Itga7 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Itga7 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Itga7 (integrin alpha 7)
Type: protein-coding
Summary: This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded transmembrane protein is the alpha subunit that forms a noncovalent hetero... |
Does Knockout of Prkacb in Immortal mouse chromaffin cells causally result in cell viability? | 1 | 2,469 | Knockout | Prkacb | cell viability | Immortal mouse chromaffin cells | Gene: Prkacb (protein kinase, cAMP dependent, catalytic, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pat... |
Does Knockout of Dhdh in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Dhdh | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Dhdh (dihydrodiol dehydrogenase)
Type: protein-coding
Summary: Enables D-xylose 1-dehydrogenase (NADP+) activity. Acts upstream of or within D-xylose catabolic process. Is expressed in nervous system and respiratory system. Orthologous to human DHDH (dihydrodiol dehydrogenase). [provided by Allian... |
Does Knockout of Ccdc82 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Ccdc82 | cell proliferation | Regulatory T cell | Gene: Ccdc82 (coiled-coil domain containing 82)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6PG04
Entrez ID: 66396 |
Does Knockout of Amz2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Amz2 | cell proliferation | Colonic Cancer Cell Line | Gene: Amz2 (archaelysin family metallopeptidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity
Pathways:
UniProt: Q400C8
Entrez ID: 13929 |
Does Knockout of Gm10330 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Gm10330 | phagocytosis | macrophage | Gene: Gm10330 (predicted gene 10330)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Crxos in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Crxos | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Crxos (cone-rod homeobox, opposite strand)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst hatching, embryonic placenta development, positive regulation of stem cell differentiation, regulation of transcription by RNA polymerase II, stem cell population m... |
Does Knockout of Gm10638 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Gm10638 | cell proliferation | Colonic Cancer Cell Line | Gene: Gm10638 (predicted gene 10638)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Zfp708 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Zfp708 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Zfp708 (zinc finger protein 708)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transposable element silencing; MF: DNA binding, DNA-binding transcription factor activity, ... |
Does Knockout of Mir495 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Mir495 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Mir495 (microRNA 495)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I... |
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