prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Chd1l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Chd1l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Chd1l (chromodomain helicase DNA binding protein 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, chromatin remodeling; MF: ATP binding, ATP hydrolysis activity, ATP-dependent chromatin remodeler activity, DNA helicase activity, histone reader activity, hydrolase activity, nucleosome binding, nucleotide binding, poly-ADP-D-ribose modification-dependent protein binding; CC: chromosome, nucleoplasm, nucleus, site of DNA damage, site of double-strand break
Pathways: DNA Repair, Dual Incision in GG-NER, Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), Nucleotide Excision Repair
UniProt: Q9CXF7
Entrez ID: 68058
|
Does Knockout of Defa24 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Defa24
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Defa24 (defensin, alpha, 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, disruption of plasma membrane integrity in another organism, innate immune response, killing by host of symbiont cells, killing of cells of another organism, positive regulation of interleukin-8 production, positive regulation of membrane permeability, protein homotetramerization; MF: pore-forming activity, protein homodimerization activity; CC: extracellular region, extracellular space, midbody, secretory granule
Pathways: Alpha-defensins, Antimicrobial peptides, Defensins, Immune System, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Staphylococcus aureus infection - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q5G865
Entrez ID: 503491
|
Does Knockout of Eef1a2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Eef1a2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Eef1a2 (eukaryotic translation elongation factor 1 alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of apoptotic process, regulation of postsynaptic specialization assembly, translation, translational elongation; MF: GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein kinase binding, translation elongation factor activity; CC: GABA-ergic synapse, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, eukaryotic translation elongation factor 1 complex, membrane, myelin sheath, neuronal cell body, synapse
Pathways: Legionellosis - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: P62631
Entrez ID: 13628
|
Does Knockout of Sf3b6 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,412
|
Knockout
|
Sf3b6
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Sf3b6 (splicing factor 3B, subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, blastocyst formation, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding; CC: U12-type spliceosomal complex, U2-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Spliceosome - Mus musculus (mouse)
UniProt: P59708
Entrez ID: 66055
|
Does Knockout of Krt14 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Krt14
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Krt14 (keratin 14)
Type: protein-coding
Summary: This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: epithelial cell differentiation, hair cycle, intermediate filament bundle assembly, intermediate filament organization, keratinocyte differentiation, morphogenesis of an epithelium, response to radiation, stem cell differentiation; MF: keratin filament binding, protein binding, structural constituent of skin epidermis, structural molecule activity; CC: basal part of cell, cell periphery, cornified envelope, cytoplasm, cytoskeleton, intermediate filament, keratin filament, nucleus
Pathways: Cell junction organization, Cell-Cell communication, Developmental Biology, Estrogen signaling pathway - Mus musculus (mouse), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Mus musculus (mouse), Type I hemidesmosome assembly
UniProt: Q61781
Entrez ID: 16664
|
Does Knockout of Tmem25 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Tmem25
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmem25 (transmembrane protein 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of excitatory postsynaptic potential, regulation of protein stability; CC: endosome, extracellular region, late endosome, lysosome, membrane, plasma membrane
Pathways:
UniProt: Q9DCF1
Entrez ID: 71687
|
Does Knockout of Grsf1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Grsf1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Grsf1 (G-rich RNA sequence binding factor 1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Acts upstream of or within anterior/posterior pattern specification and morphogenesis of embryonic epithelium. Located in mitochondrion. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and sensory organ. Orthologous to human GRSF1 (G-rich RNA sequence binding factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: anterior/posterior pattern specification, mRNA processing, morphogenesis of embryonic epithelium, positive regulation of mitochondrial RNA catabolic process, regulation of RNA splicing, tRNA processing; MF: RNA binding, mRNA binding, nucleic acid binding; CC: cytoplasm, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribonucleoprotein granule
Pathways:
UniProt: Q8C5Q4
Entrez ID: 231413
|
Does Knockout of Miga1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Miga1
|
cell cycle progression
|
breast epithelium
|
Gene: Miga1 (mitoguardin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial fusion; MF: protein heterodimerization activity, protein homodimerization activity; CC: membrane, mitochondrial outer membrane, mitochondrion, plasma membrane
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA
UniProt: Q4QQM5
Entrez ID: 215708
|
Does Knockout of Pnck in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Pnck
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pnck (pregnancy upregulated non-ubiquitously expressed CaM kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9QYK9
Entrez ID: 93843
|
Does Knockout of Gm4567 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm4567
|
phagocytosis
|
macrophage
|
Gene: Gm4567 (predicted gene 4567)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, molecular_function, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: Q3UTA8
Entrez ID: 100043645
|
Does Knockout of Pex7 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Pex7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pex7 (peroxisomal biogenesis factor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endochondral ossification, ether lipid biosynthetic process, fatty acid beta-oxidation, neuron migration, peroxisome organization, protein import into peroxisome matrix, protein targeting to peroxisome, protein transport; MF: enzyme binding, peroxisome matrix targeting signal-2 binding, protein homodimerization activity; CC: cytoplasm, cytosol, peroxisomal matrix, peroxisome
Pathways: Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization
UniProt: P97865
Entrez ID: 18634
|
Does Knockout of Serpina1d in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Serpina1d
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Serpina1d (serine (or cysteine) peptidase inhibitor, clade A, member 1D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: response to chromate, response to cytokine, response to lead ion, response to methanol, response to peptide hormone; MF: endopeptidase inhibitor activity, identical protein binding, peptidase inhibitor activity, protease binding, serine-type endopeptidase inhibitor activity; CC: Golgi apparatus, endoplasmic reticulum, extracellular region, extracellular space
Pathways: Complement and coagulation cascades - Mus musculus (mouse)
UniProt: Q00897
Entrez ID: 20703
|
Does Knockout of Arhgef37 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Arhgef37
|
response to bacteria
|
renal medulla cell line
|
Gene: Arhgef37 (Rho guanine nucleotide exchange factor 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity; CC: cellular_component, cytoplasm
Pathways: Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, Signal Transduction, Signaling by GPCR, p75 NTR receptor-mediated signalling
UniProt: A1IGU4
Entrez ID: 328967
|
Does Knockout of Dnajb11 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Dnajb11
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Dnajb11 (DnaJ heat shock protein family (Hsp40) member B11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA modification, negative regulation of neurogenesis, protein folding, protein maturation; MF: misfolded protein binding, protein binding, signaling receptor binding, unfolded protein binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, extracellular space, nucleus, protein folding chaperone complex
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q99KV1
Entrez ID: 67838
|
Does Knockout of Klhl10 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Klhl10
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Klhl10 (kelch-like 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell morphogenesis, fertilization, homeostasis of number of cells within a tissue, male genitalia morphogenesis, male gonad development, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, spermatid development, spermatogenesis; MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q9D5V2
Entrez ID: 66720
|
Does Knockout of Zfp775 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Zfp775
|
cell proliferation
|
Regulatory T cell
|
Gene: Zfp775 (zinc finger protein 775)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q8BI73
Entrez ID: 243372
|
Does Knockout of Abi2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Abi2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Abi2 (abl interactor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, camera-type eye development, cell migration, cell projection morphogenesis, dendrite development, learning or memory, lens fiber cell morphogenesis, mitophagy, nervous system development, neuron migration, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of lamellipodium assembly, postsynapse organization, postsynaptic actin cytoskeleton organization, regulation of dendritic spine morphogenesis, zonula adherens assembly; MF: identical protein binding, signaling adaptor activity, small GTPase binding, ubiquitin protein ligase binding; CC: SCAR complex, actin filament, actin-based cell projection, adherens junction, anchoring junction, cell projection, cytoplasm, cytoskeleton, cytosol, dendrite, dendritic spine, filopodium, filopodium tip, glutamatergic synapse, lamellipodium, postsynaptic actin cytoskeleton, synapse
Pathways: Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: P62484
Entrez ID: 329165
|
Does Knockout of Rnf185 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Rnf185
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Rnf185 (ring finger protein 185)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, autophagy, cGAS/STING signaling pathway, defense response to virus, immune system process, innate immune response, positive regulation of ERAD pathway, positive regulation of innate immune response, positive regulation of type I interferon-mediated signaling pathway, protein K27-linked ubiquitination, protein autoubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein-containing complex binding, transferase activity, ubiquitin binding, ubiquitin protein ligase activity, ubiquitin-like protein conjugating enzyme binding, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Co-inhibition by PD-1, Immune System, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Transport of small molecules
UniProt: Q91YT2
Entrez ID: 193670
|
Does Knockout of Nr1i2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Nr1i2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nr1i2 (nuclear receptor subfamily 1, group I, member 2)
Type: protein-coding
Summary: Enables nuclear receptor activity. Involved in cellular response to molecule of bacterial origin. Acts upstream of or within gene expression and positive regulation of gene expression. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; genitourinary system; gut; liver; and nervous system. Orthologous to human NR1I2 (nuclear receptor subfamily 1 group I member 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, cellular response to molecule of bacterial origin, gene expression, intracellular receptor signaling pathway, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, xenobiotic catabolic process, xenobiotic metabolic process, xenobiotic transport; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, nuclear receptor activity, nuclear receptor binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: intermediate filament cytoskeleton, nuclear body, nucleoplasm, nucleus, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Nuclear Receptor transcription pathway, Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors
UniProt: O54915
Entrez ID: 18171
|
Does Knockout of Peg3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Peg3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Peg3 (paternally expressed 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: autophagosome, cytoplasm, nucleus
Pathways:
UniProt: Q3URU2
Entrez ID: 18616
|
Does Knockout of Try5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Try5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Try5 (trypsin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: calcium ion binding, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: acrosomal vesicle, cytoplasmic vesicle, extracellular region, extracellular space
Pathways: Activation of Matrix Metalloproteinases, Alpha-defensins, Antimicrobial peptides, Defensins, Degradation of the extracellular matrix, Extracellular matrix organization, Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neutrophil degranulation, Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q9QUK9
Entrez ID: 103964
|
Does Knockout of Mesd in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Mesd
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mesd (mesoderm development LRP chaperone)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, mesoderm development, negative regulation of protein glycosylation, ossification, phagocytosis, positive regulation of Wnt signaling pathway, positive regulation of skeletal muscle acetylcholine-gated channel clustering, protein folding, protein localization to cell surface, protein localization to plasma membrane; MF: identical protein binding, low-density lipoprotein particle receptor binding, protein binding, protein folding chaperone; CC: endoplasmic reticulum, plasma membrane
Pathways:
UniProt: Q9ERE7
Entrez ID: 67943
|
Does Knockout of Pkig in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Pkig
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Pkig (protein kinase inhibitor, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of protein import into nucleus, negative regulation of transcription by RNA polymerase II; MF: cAMP-dependent protein kinase inhibitor activity, protein kinase inhibitor activity; CC: cytoplasm, nucleus
Pathways:
UniProt: O70139
Entrez ID: 18769
|
Does Knockout of Pdha2 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Pdha2
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Pdha2 (pyruvate dehydrogenase E1 alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucose metabolic process, pyruvate decarboxylation to acetyl-CoA, tricarboxylic acid cycle; MF: metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, pyruvate dehydrogenase (acetyl-transferring) activity; CC: mitochondrial matrix, mitochondrion, nucleolus, oxidoreductase complex, pyruvate dehydrogenase complex
Pathways: Aerobic respiration and respiratory electron transport, Central carbon metabolism in cancer - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, PDH complex synthesizes acetyl-CoA from PYR, Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), Regulation of pyruvate dehydrogenase (PDH) complex, Regulation of pyruvate metabolism, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, acetyl-CoA biosynthesis (from pyruvate), superpathway of acetyl-CoA biosynthesis
UniProt: P35487
Entrez ID: 18598
|
Does Knockout of Gm10392 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Gm10392
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm10392 (predicted gene 10392)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100049168
|
Does Knockout of Cyp2j12 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Cyp2j12
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Cyp2j12 (cytochrome P450, family 2, subfamily j, polypeptide 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxygenase P450 pathway, icosanoid metabolic process, linoleic acid metabolic process, organic acid metabolic process, xenobiotic metabolic process; MF: arachidonate 11,12-epoxygenase activity, arachidonate 14,15-epoxygenase activity, arachidonate epoxygenase activity, heme binding, iron ion binding, isomerase activity, linoleic acid epoxygenase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse)
UniProt: G3UZ89, G3UXT0
Entrez ID: 242546
|
Does Knockout of Gpr89 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Gpr89
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gpr89 (G protein-coupled receptor 89)
Type: protein-coding
Summary: Predicted to enable voltage-gated monoatomic anion channel activity. Involved in T cell differentiation. Acts upstream of or within skin development. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in Golgi cisterna membrane. Is expressed in several structures, including clavicle; ganglia; gut; liver lobe; and ventral grey horn. Orthologous to human GPR89A (G protein-coupled receptor 89A) and GPR89B (G protein-coupled receptor 89B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: T cell differentiation, intracellular pH reduction, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, protein transport, skin development; MF: protein binding, voltage-gated monoatomic anion channel activity; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, Golgi-associated vesicle membrane, membrane, monoatomic ion channel complex
Pathways:
UniProt: Q8BS95
Entrez ID: 67549
|
Does Knockout of Slc6a14 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Slc6a14
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Slc6a14 (solute carrier family 6 (neurotransmitter transporter), member 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: (R)-carnitine transmembrane transport, alanine transport, amine transport, amino acid import across plasma membrane, amino acid transport, beta-alanine transport, branched-chain amino acid transport, chloride transport, glycine import across plasma membrane, response to toxic substance, sodium ion transmembrane transport; MF: (R)-carnitine transmembrane transporter activity, alanine transmembrane transporter activity, amine transmembrane transporter activity, aromatic amino acid transmembrane transporter activity, beta-alanine transmembrane transporter activity, branched-chain amino acid:sodium symporter activity, neutral, basic amino acid:sodium:chloride symporter activity, symporter activity; CC: apical plasma membrane, brush border membrane, membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, SLC-mediated transport of neurotransmitters, Transport of small molecules
UniProt: Q9JMA9
Entrez ID: 56774
|
Does Knockout of Zyg11a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Zyg11a
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Zyg11a (zyg-11 family member A, cell cycle regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A1Y7VNL1, A0A217FL76, F8WHU3
Entrez ID: 230590
|
Does Knockout of Vav1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Vav1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Vav1 (vav 1 oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell proliferation, G protein-coupled receptor signaling pathway, T cell activation, T cell costimulation, T cell differentiation, cell migration, cell surface receptor signaling pathway, immune response, immune response-regulating cell surface receptor signaling pathway, integrin-mediated signaling pathway, intracellular signal transduction, natural killer cell activation, natural killer cell mediated cytotoxicity, neutrophil chemotaxis, phagocytosis, positive regulation of cell adhesion, positive regulation of natural killer cell mediated cytotoxicity, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, reactive oxygen species metabolic process, regulation of immune response, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, metal ion binding, phosphorylation-dependent protein binding, phosphotyrosine residue binding, protein binding, zinc ion binding; CC: cell-cell junction, cytoplasm, cytosol
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Azathioprine ADME, B cell receptor signaling pathway - Mus musculus (mouse), CD28 dependent Vav1 pathway, Cell death signalling via NRAGE, NRIF and NADE, Chemokine signaling pathway - Mus musculus (mouse), Co-stimulation by CD28, Cytokine Signaling in Immune system, Death Receptor Signaling, Drug ADME, Erythropoietin activates RAS, FCERI mediated Ca+2 mobilization, FCERI mediated MAPK activation, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Focal adhesion - Mus musculus (mouse), G alpha (12/13) signalling events, GPCR downstream signalling, GPVI-mediated activation cascade, Hemostasis, Immune System, Innate Immune System, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), NRAGE signals death through JNK, Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Platelet activation, signaling and aggregation, Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOG GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Regulation of signaling by CBL, Signal Transduction, Signaling by Erythropoietin, Signaling by GPCR, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by VEGF, Signaling by the B Cell Receptor (BCR), T cell receptor signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: P27870
Entrez ID: 22324
|
Does Knockout of Nmrk2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Nmrk2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nmrk2 (nicotinamide riboside kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway, NADP+ biosynthetic process, negative regulation of myoblast differentiation, nicotinamide riboside metabolic process, pyridine nucleotide biosynthetic process; MF: ATP binding, kinase activity, metal ion binding, nicotinate riboside kinase activity, nucleotide binding, protein binding, ribosylnicotinamide kinase activity, ribosylnicotinate kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, plasma membrane
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NAD salvage pathway II, NAD salvage pathway III, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nicotinate metabolism
UniProt: Q9D7C9
Entrez ID: 69564
|
Does Knockout of Eddm3b in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Eddm3b
|
cell proliferation
|
Regulatory T cell
|
Gene: Eddm3b (epididymal protein 3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8K0E4
Entrez ID: 219026
|
Does Knockout of Grip1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Grip1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Grip1 (glutamate receptor interacting protein 1)
Type: protein-coding
Summary: This gene encodes a protein containing multiple PDZ (post synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 protein) domains. The encoded protein acts as a mediator between cytoskeletal and membrane proteins, particularly in neuronal cells, and facilitates complex formation at the cell membrane. Mutation of this gene can cause embryonic lethality resulting from defects of the dermo-epidermal junction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: cellular response to brain-derived neurotrophic factor stimulus, cellular response to phorbol 13-acetate 12-myristate, dendrite arborization, intracellular protein localization, nervous system development, neurotransmitter receptor transport, endosome to postsynaptic membrane, positive regulation of dendrite morphogenesis, positive regulation of neuron projection arborization, positive regulation of protein localization to plasma membrane, regulation of synaptic scaling, vesicle-mediated transport in synapse; MF: GTPase binding, PDZ domain binding, ionotropic glutamate receptor binding, protein binding, protein-containing complex binding, signaling receptor binding; CC: GABA-ergic synapse, cell projection, cytoplasm, cytoplasmic vesicle, dendrite, dendritic shaft, dendritic spine, dendritic spine head, dendritic spine neck, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, exocyst, glutamatergic synapse, membrane, membrane raft, microtubule, neuron projection, neuronal cell body, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynapse, postsynaptic density, postsynaptic membrane, presynapse, presynaptic active zone, presynaptic membrane, proximal dendrite, recycling endosome, spine synapse, synapse, synaptic cleft, synaptic membrane, terminal bouton
Pathways: Glutamate binding, activation of AMPA receptors and synaptic plasticity, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses
UniProt: Q925T6
Entrez ID: 74053
|
Does Knockout of Tcf24 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Tcf24
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tcf24 (transcription factor 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: developmental process, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein dimerization activity
Pathways:
UniProt: V9GWT9, Q3UV43
Entrez ID: 100039596
|
Does Knockout of Ints8 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ints8
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ints8 (integrator complex subunit 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, protein localization to chromatin, snRNA 3'-end processing, snRNA processing; CC: INTAC complex, chromatin, chromosome, integrator complex, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q80V86
Entrez ID: 72656
|
Does Knockout of Tmem139 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Tmem139
|
phagocytosis
|
macrophage
|
Gene: Tmem139 (transmembrane protein 139)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: E9PX92, Q8C6T0
Entrez ID: 109218
|
Does Knockout of Plcxd2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Plcxd2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Plcxd2 (phosphatidylinositol-specific phospholipase C, X domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lipid catabolic process, lipid metabolic process, signal transduction; MF: hydrolase activity, molecular_function, phosphoric diester hydrolase activity; CC: cellular_component, nucleus
Pathways:
UniProt: B2RXA1
Entrez ID: 433022
|
Does Knockout of Pnpla8 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Pnpla8
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pnpla8 (patatin-like phospholipase domain containing 8)
Type: protein-coding
Summary: Enables calcium-independent phospholipase A2 activity. Involved in cardiolipin metabolic process; regulation of cellular response to oxidative stress; and triglyceride homeostasis. Located in mitochondrion and peroxisome. Orthologous to human PNPLA8 (patatin like phospholipase domain containing 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: arachidonate metabolic process, arachidonate secretion, cardiolipin metabolic process, fatty acid metabolic process, intracellular signal transduction, linoleic acid metabolic process, lipid catabolic process, lipid homeostasis, lipid metabolic process, phosphatidylcholine catabolic process, phosphatidylethanolamine catabolic process, prostaglandin biosynthetic process, regulation of cellular response to oxidative stress, triglyceride homeostasis; MF: calcium-independent phospholipase A2 activity, hydrolase activity, phosphatidylcholine lysophospholipase activity, phospholipase A1 activity, phospholipase A2 activity, phospholipase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial membrane, mitochondrion, peroxisomal membrane, peroxisome
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism
UniProt: Q8K1N1
Entrez ID: 67452
|
Does Knockout of Rps27rt in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Rps27rt
|
cell cycle progression
|
breast epithelium
|
Gene: Rps27rt (ribosomal protein S27, retrogene)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in rRNA processing and ribosomal small subunit biogenesis. Predicted to be located in cytosolic ribosome and nucleus. Predicted to be part of cytosolic small ribosomal subunit and small-subunit processome. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 17. Orthologous to human RPS27 (ribosomal protein S27). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cap-dependent Translation Initiation, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Coronavirus disease - COVID-19 - Mus musculus (mouse), EML4 and NUDC in mitotic spindle formation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, M Phase, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6ZWU9
Entrez ID: 100043813
|
Does Knockout of Sec14l2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Sec14l2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sec14l2 (SEC14-like lipid binding 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: enzyme activator activity, lipid binding, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q99J08
Entrez ID: 67815
|
Does Knockout of Zfand3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Zfand3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfand3 (zinc finger, AN1-type domain 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q497H0
Entrez ID: 21769
|
Does Knockout of Rps3a1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Rps3a1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Rps3a1 (ribosomal protein S3A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cytoplasmic translation, negative regulation of apoptotic process, ribosomal small subunit biogenesis, translation; MF: mRNA 5'-UTR binding, mRNA binding, protein binding, structural constituent of ribosome, translation initiation factor binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, nucleolus, nucleus, postsynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P97351
Entrez ID: 20091
|
Does Knockout of Cadm2 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 1
| 1,839
|
Knockout
|
Cadm2
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Cadm2 (cell adhesion molecule 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, synaptic membrane adhesion; CC: GABA-ergic synapse, axon, cell projection, glutamatergic synapse, membrane, neuronal cell body membrane, plasma membrane, postsynaptic membrane, synapse
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization
UniProt: Q8BLQ9
Entrez ID: 239857
|
Does Knockout of Pafah2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Pafah2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pafah2 (platelet-activating factor acetylhydrolase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid catabolic process, lipid metabolic process, negative regulation of apoptotic process; MF: 1-alkyl-2-acetylglycerophosphocholine esterase activity, hydrolase activity, platelet-activating factor acetyltransferase activity, transferase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Ether lipid metabolism - Mus musculus (mouse), Hemostasis, Platelet homeostasis
UniProt: Q8VDG7
Entrez ID: 100163
|
Does Knockout of Serpinb3d in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Serpinb3d
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Serpinb3d (serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, enzyme binding, peptidase inhibitor activity, protease binding, serine-type endopeptidase inhibitor activity, virus receptor activity; CC: cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, extracellular space, nucleus, plasma membrane
Pathways: Amoebiasis - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q6UKZ0
Entrez ID: 394252
|
Does Knockout of Tnnc1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Tnnc1
|
phagocytosis
|
macrophage
|
Gene: Tnnc1 (troponin C, cardiac/slow skeletal)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle cell contraction, cardiac muscle contraction, diaphragm contraction, muscle filament sliding, regulation of muscle contraction, regulation of muscle filament sliding speed, response to metal ion, skeletal muscle contraction, transition between fast and slow fiber, ventricular cardiac muscle tissue morphogenesis; MF: actin filament binding, calcium ion binding, calcium-dependent protein binding, cytoskeletal protein binding, metal ion binding, protein homodimerization activity, troponin I binding, troponin T binding; CC: cardiac Troponin complex, contractile muscle fiber, sarcomere, troponin complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Muscle contraction, Striated Muscle Contraction
UniProt: P19123
Entrez ID: 21924
|
Does Knockout of Cela3a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Cela3a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cela3a (chymotrypsin-like elastase family, member 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
Pathways: Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: A2A9U8
Entrez ID: 242711
|
Does Knockout of Erf in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Erf
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Erf (Ets2 repressor factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chorio-allantoic fusion, ectodermal cell differentiation, in utero embryonic development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, trophoblast giant cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific DNA binding; CC: cytosol, nucleoplasm, nucleus, plasma membrane
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Oncogene Induced Senescence
UniProt: P70459
Entrez ID: 13875
|
Does Knockout of Aff1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Aff1
|
cell cycle progression
|
breast epithelium
|
Gene: Aff1 (AF4/FMR2 family, member 1)
Type: protein-coding
Summary: This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. Knockout of the mouse gene by homologous recombination severely affects early events in lymphopoiesis, including precursor proliferation or recruitment, but is dispensable for terminal differentiation. In addition, an autosomal dominant missense mutation results in several phenotypes including ataxia and adult-onset Purkinje cell loss in the cerebellum, indicating a role in Purkinje cell maintenance and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: DNA-templated transcription, positive regulation of DNA-templated transcription, regulation of gene expression; CC: nucleus, super elongation complex, transcription elongation factor complex
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: E9Q921, A3KMF4, Q3UP77, Q3UQD9, B1AVP1
Entrez ID: 17355
|
Does Knockout of Hikeshi in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Hikeshi
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hikeshi (heat shock protein nuclear import factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, cellular response to heat, lung development, protein import into nucleus, protein transport; MF: Hsp70 protein binding, nuclear import signal receptor activity; CC: cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q9DD02
Entrez ID: 67669
|
Does Knockout of Gm10941 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Gm10941
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gm10941 (predicted gene 10941)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100169878
|
Does Knockout of Las1l in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Las1l
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Las1l (LAS1-like (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing; MF: endonuclease activity, hydrolase activity; CC: Las1 complex, MLL1 complex, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: A2BE28
Entrez ID: 76130
|
Does Knockout of Hoxd3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Hoxd3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hoxd3 (homeobox D3)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including glossopharyngeal nerve morphogenesis; skeletal system development; and thyroid gland development. Predicted to be located in aggresome and nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and gut. Orthologous to human HOXD3 (homeobox D3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription, Notch signaling pathway, anterior/posterior pattern specification, cartilage development, cell-matrix adhesion, embryonic skeletal system morphogenesis, glossopharyngeal nerve morphogenesis, positive regulation of gene expression, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, thyroid gland development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: aggresome, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: P09027
Entrez ID: 15434
|
Does Knockout of Rsrp1 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Rsrp1
|
phagocytosis
|
macrophage
|
Gene: Rsrp1 (arginine/serine rich protein 1)
Type: protein-coding
Summary: Predicted to be involved in spliceosomal complex assembly. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; extraembryonic component; and retina. Orthologous to human RSRP1 (arginine and serine rich protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, spliceosomal complex assembly; CC: cellular_component, nucleus
Pathways:
UniProt: Q3UC65
Entrez ID: 27981
|
Does Knockout of Ankrd66 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Ankrd66
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ankrd66 (ankyrin repeat domain 66)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of canonical Wnt signaling pathway, positive regulation of telomere capping, protein localization to chromosome, telomeric region; MF: NAD+ poly-ADP-ribosyltransferase activity, molecular_function; CC: cellular_component, cytoplasm, nucleus
Pathways:
UniProt: J3QNN4
Entrez ID: 100043332
|
Does Knockout of Cpne3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Cpne3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cpne3 (copine III)
Type: protein-coding
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ERBB2 signaling pathway, cellular response to calcium ion, cellular response to growth factor stimulus, positive regulation of cell migration; MF: calcium-dependent phospholipid binding, calcium-dependent protein binding, metal ion binding, protein serine/threonine kinase activity, receptor tyrosine kinase binding; CC: anchoring junction, cell junction, cytoplasm, cytosol, focal adhesion, membrane, mitochondrion, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Glycerophospholipid biosynthesis, Immune System, Innate Immune System, Metabolism, Metabolism of lipids, Neutrophil degranulation, Phospholipid metabolism
UniProt: Q8BT60
Entrez ID: 70568
|
Does Knockout of Star in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Star
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Star (steroidogenic acute regulatory protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid biosynthetic process, biphenyl metabolic process, cellular response to alkaloid, cellular response to antibiotic, cellular response to cAMP, cellular response to cadmium ion, cellular response to dexamethasone stimulus, cellular response to epinephrine stimulus, cellular response to fibroblast growth factor stimulus, cellular response to follicle-stimulating hormone stimulus, cellular response to glucose stimulus, cellular response to gonadotropin stimulus, cellular response to growth hormone stimulus, cellular response to insulin stimulus, cellular response to interferon-alpha, cellular response to lipopolysaccharide, cellular response to luteinizing hormone stimulus, cellular response to metal ion, cellular response to transforming growth factor beta stimulus, cellular response to type II interferon, cholesterol metabolic process, circadian rhythm, dibenzo-p-dioxin metabolic process, estrogen biosynthetic process, glucocorticoid metabolic process, intracellular cholesterol transport, lipid metabolic process, lipid transport, male gonad development, negative regulation of neuron apoptotic process, organic acid metabolic process, phenol-containing compound metabolic process, phthalate metabolic process, positive regulation of bile acid biosynthetic process, positive regulation of gene expression, positive regulation of neurogenesis, regulation of neuronal synaptic plasticity, regulation of steroid biosynthetic process, response to activity, response to benzoic acid, response to corticosterone, response to estrogen, response to ethanol, response to fungicide, response to gonadotropin, response to herbicide, response to hydrogen peroxide, response to insecticide, response to ionizing radiation, response to lead ion, response to leptin, response to nicotine, response to nutrient, response to nutrient levels, response to peptide hormone, response to retinoic acid, response to steroid hormone, response to toxic substance, response to xenobiotic stimulus, steroid biosynthetic process, steroid metabolic process, testosterone biosynthetic process; MF: cholesterol binding, cholesterol transfer activity, lipid binding; CC: mitochondrial crista, mitochondrion, neuronal cell body
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Cholesterol metabolism - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroid hormones, Metabolism of steroids, Mitochondrial protein degradation, Ovarian steroidogenesis - Mus musculus (mouse), Pregnenolone biosynthesis
UniProt: P51557
Entrez ID: 20845
|
Does Knockout of Ttbk1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Ttbk1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ttbk1 (tau tubulin kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: learning or memory, negative regulation of gene expression, positive regulation of astrocyte activation, positive regulation of gene expression, positive regulation of microglial cell activation, positive regulation of protein polymerization, signal transduction; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, tau protein binding, tau-protein kinase activity, transferase activity; CC: cytoplasm, cytosol, microtubule associated complex, microtubule cytoskeleton, neuronal cell body, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q6PCN3
Entrez ID: 106763
|
Does Knockout of 4930453N24Rik in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
4930453N24Rik
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: 4930453N24Rik (RIKEN cDNA 4930453N24 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, positive regulation of apoptotic process; CC: nucleus
Pathways:
UniProt: Q3TTL0
Entrez ID: 67609
|
Does Knockout of Chit1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Chit1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Chit1 (chitinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, chitin catabolic process, polysaccharide catabolic process; MF: chitin binding, chitinase activity, endochitinase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds; CC: extracellular region, extracellular space, lysosome
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Digestion, Digestion and absorption, Digestion of dietary carbohydrate, Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q9D7Q1
Entrez ID: 71884
|
Does Knockout of Nxf1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Nxf1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nxf1 (nuclear RNA export factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, mRNA export from nucleus, mRNA transport, poly(A)+ mRNA export from nucleus, protein transport; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, cytoplasmic stress granule, nuclear RNA export factor complex, nuclear envelope, nuclear inclusion body, nuclear pore, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q99JX7
Entrez ID: 53319
|
Does Knockout of Lgals12 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Lgals12
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Lgals12 (lectin, galactose binding, soluble 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, intrinsic apoptotic signaling pathway; MF: carbohydrate binding, lactose binding; CC: cytoplasm, mitochondrion, nucleus
Pathways:
UniProt: Q91VD1
Entrez ID: 56072
|
Does Knockout of Ropn1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Ropn1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ropn1 (ropporin, rhophilin associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium organization, flagellated sperm motility, protein localization to cilium, sperm capacitation; MF: identical protein binding, protein binding, protein heterodimerization activity; CC: cell projection, cilium, cytoplasm, cytosol, motile cilium, sperm cytoplasmic droplet, sperm flagellum, sperm principal piece
Pathways:
UniProt: Q9ESG2
Entrez ID: 76378
|
Does Knockout of Nucb1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Nucb1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nucb1 (nucleobindin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of protein targeting, small GTPase-mediated signal transduction; MF: DNA binding, G-protein alpha-subunit binding, calcium ion binding, guanyl-nucleotide exchange factor activity, metal ion binding; CC: Golgi apparatus, Golgi cisterna membrane, Golgi-associated vesicle, cytoplasm, early endosome, endomembrane system, endoplasmic reticulum-Golgi intermediate compartment, extracellular region, extracellular space, extrinsic component of Golgi membrane, lumenal side of Golgi membrane, membrane, trans-Golgi network
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q02819
Entrez ID: 18220
|
Does Knockout of Rab27b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Rab27b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rab27b (RAB27B, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal protein transport, exocytosis, multivesicular body sorting pathway, positive regulation of exocytosis, regulation of exocytosis, synaptic vesicle endocytosis; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, myosin V binding, nucleotide binding, protein binding, protein domain specific binding; CC: Golgi apparatus, Golgi stack, apical plasma membrane, axon cytoplasm, cytoplasm, endomembrane system, endosome, exocytic vesicle, late endosome, melanosome, membrane, multivesicular body membrane, secretory granule, synaptic vesicle membrane, trans-Golgi network transport vesicle, zymogen granule membrane
Pathways: Hemostasis, Membrane Trafficking, Metabolism of proteins, Pancreatic secretion - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Response to elevated platelet cytosolic Ca2+, Vesicle-mediated transport
UniProt: Q99P58
Entrez ID: 80718
|
Does Knockout of Kcnj14 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Kcnj14
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kcnj14 (potassium inwardly-rectifying channel, subfamily J, member 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion import across plasma membrane, potassium ion transport, regulation of monoatomic ion transmembrane transport; MF: inward rectifier potassium channel activity; CC: dendrite, membrane, monoatomic ion channel complex, neuronal cell body, plasma membrane
Pathways: Cardiac conduction, Cholinergic synapse - Mus musculus (mouse), Classical Kir channels, Inwardly rectifying K+ channels, Muscle contraction, Neuronal System, Oxytocin signaling pathway - Mus musculus (mouse), Phase 4 - resting membrane potential, Potassium Channels
UniProt: Q8JZN3
Entrez ID: 211480
|
Does Knockout of Adnp2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Adnp2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adnp2 (ADNP homeobox 2)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and zinc ion binding activity. Involved in nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; brain; genitourinary system; pancreas; and retina nuclear layer. Orthologous to human ADNP2 (ADNP homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: nervous system development, regulation of gene expression; MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8CHC8
Entrez ID: 240442
|
Does Knockout of Ccdc152 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ccdc152
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ccdc152 (coiled-coil domain containing 152)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A2I3BPP3, E9PX14
Entrez ID: 100039139
|
Does Knockout of Cyp2a12 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Cyp2a12
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cyp2a12 (cytochrome P450, family 2, subfamily a, polypeptide 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: coumarin metabolic process, epoxygenase P450 pathway, xenobiotic metabolic process; MF: arachidonate epoxygenase activity, coumarin 7-hydroxylase activity, enzyme binding, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, steroid hydroxylase activity; CC: cytoplasm, cytoplasmic microtubule, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Biological oxidations, CYP2E1 reactions, Cytochrome P450 - arranged by substrate type, Fatty acids, Metabolism, Phase I - Functionalization of compounds, Retinol metabolism - Mus musculus (mouse), Xenobiotics, bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: P56593
Entrez ID: 13085
|
Does Knockout of Epha7 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Epha7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Epha7 (Eph receptor A7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, axon guidance, brain development, branching morphogenesis of a nerve, cell surface receptor protein tyrosine kinase signaling pathway, central nervous system development, ephrin receptor signaling pathway, modulation of chemical synaptic transmission, negative chemotaxis, negative regulation of collateral sprouting, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of synapse assembly, nephric duct morphogenesis, nervous system development, phosphorylation, positive regulation of apoptotic process, positive regulation of neuron apoptotic process, regulation of ERK1 and ERK2 cascade, regulation of cell-cell adhesion, regulation of developmental process, regulation of peptidyl-tyrosine phosphorylation, regulation of postsynapse organization, regulation of protein autophosphorylation, retinal ganglion cell axon guidance; MF: ATP binding, GPI-linked ephrin receptor activity, axon guidance receptor activity, chemorepellent activity, ephrin receptor activity, ephrin receptor binding, growth factor binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, signaling receptor binding, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity; CC: Schaffer collateral - CA1 synapse, dendrite, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane, neuromuscular junction, neuronal cell body, plasma membrane, postsynaptic density membrane, postsynaptic membrane, postsynaptic specialization membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, Nervous system development
UniProt: Q61772
Entrez ID: 13841
|
Does Knockout of Cbln1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Cbln1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cbln1 (cerebellin 1 precursor protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellar granule cell differentiation, establishment of localization in cell, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, maintenance of synapse structure, negative regulation of excitatory postsynaptic potential, negative regulation of inhibitory synapse assembly, positive regulation of long-term synaptic depression, positive regulation of synapse assembly, protein secretion, regulation of postsynaptic density assembly, regulation of presynapse assembly, synapse organization, trans-synaptic signaling, modulating synaptic transmission; MF: identical protein binding, protein binding; CC: extracellular region, glutamatergic synapse, membrane, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic membrane, synapse, synaptic cleft, trans-synaptic protein complex
Pathways:
UniProt: Q9R171
Entrez ID: 12404
|
Does Knockout of Sun5 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Sun5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sun5 (Sad1 and UNC84 domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, protein-containing complex assembly, regulation of protein localization, spermatid development, spermatogenesis; MF: protein binding, protein-membrane adaptor activity; CC: Golgi apparatus, meiotic nuclear membrane microtubule tethering complex, membrane, nuclear envelope, nuclear inner membrane, nucleus, sperm head-tail coupling apparatus
Pathways:
UniProt: Q9DA32
Entrez ID: 76407
|
Does Knockout of Adh6a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Adh6a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Adh6a (alcohol dehydrogenase 6A (class V))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: retinoic acid metabolic process, retinol metabolic process, small molecule catabolic process; MF: alcohol dehydrogenase (NAD+) activity, all-trans-retinol dehydrogenase (NAD+) activity, metal ion binding, oxidoreductase activity, zinc ion binding; CC: cytoplasm, cytosol
Pathways:
UniProt: E9Q5Z6, Q9D932, E9Q4Y1
Entrez ID: 69117
|
Does Knockout of Gm5142 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Gm5142
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gm5142 (predicted gene 5142)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C5X9
Entrez ID: 380907
|
Does Knockout of Traf2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Traf2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Traf2 (TNF receptor-associated factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD27 signaling pathway, CD40 signaling pathway, T cell activation, TORC1 complex assembly, TORC1 signaling, TORC2 complex disassembly, TORC2 signaling, apoptotic process, cellular response to nitric oxide, innate immune response, interleukin-17-mediated signaling pathway, mRNA stabilization, negative regulation of apoptotic process, negative regulation of canonical NF-kappaB signal transduction, negative regulation of glial cell apoptotic process, non-canonical NF-kappaB signal transduction, positive regulation of JUN kinase activity, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell cytokine production, positive regulation of canonical NF-kappaB signal transduction, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of gene expression, positive regulation of interleukin-2 production, positive regulation of tumor necrosis factor-mediated signaling pathway, programmed cell death, programmed necrotic cell death, protein K63-linked ubiquitination, protein autoubiquitination, protein catabolic process, protein polyubiquitination, protein ubiquitination, protein-containing complex assembly, regulation of JNK cascade, regulation of MAPK cascade, regulation of apoptotic process, regulation of immunoglobulin production, regulation of production of molecular mediator of immune response, regulation of protein-containing complex assembly, signal transduction, signal transduction involved in regulation of gene expression, tumor necrosis factor-mediated signaling pathway; MF: CD40 receptor binding, enzyme binding, identical protein binding, lipid binding, metal ion binding, mitogen-activated protein kinase kinase kinase binding, protein binding, protein kinase binding, protein phosphatase binding, protein-containing complex binding, protein-macromolecule adaptor activity, signaling adaptor activity, sphingolipid binding, thioesterase binding, transferase activity, tumor necrosis factor binding, tumor necrosis factor receptor binding, tumor necrosis factor receptor superfamily binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: CD40 receptor complex, IRE1-TRAF2-ASK1 complex, TRAF2-GSTP1 complex, cell cortex, cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane raft, protein-containing complex, receptor complex, tumor necrosis factor receptor superfamily complex, ubiquitin ligase complex, vesicle membrane
Pathways: Adipocytokine signaling pathway - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis, Apoptosis - Mus musculus (mouse), CASP8 activity is inhibited, Caspase activation via Death Receptors in the presence of ligand, Caspase activation via extrinsic apoptotic signalling pathway, Cytokine Signaling in Immune system, Death Receptor Signaling, Deubiquitination, Dimerization of procaspase-8, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Programmed Cell Death, Protein processing in endoplasmic reticulum - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), RIPK1-mediated regulated necrosis, Regulated Necrosis, Regulation by c-FLIP, Regulation of NF-kappa B signaling, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Small cell lung cancer - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), TAK1-dependent IKK and NF-kappa-B activation , TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNF signaling, TNF signaling pathway - Mus musculus (mouse), TNFR1-induced NF-kappa-B signaling pathway, TNFR1-induced proapoptotic signaling, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ub-specific processing proteases, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: P39429
Entrez ID: 22030
|
Does Knockout of Ppat in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Ppat
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ppat (phosphoribosyl pyrophosphate amidotransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, L-glutamine catabolic process, purine nucleobase biosynthetic process, purine nucleotide biosynthetic process; MF: 4 iron, 4 sulfur cluster binding, amidophosphoribosyltransferase activity, catalytic activity, glycosyltransferase activity, identical protein binding, iron-sulfur cluster binding, metal ion binding, transferase activity
Pathways: 5-aminoimidazole ribonucleotide biosynthesis I, 5-aminoimidazole ribonucleotide biosynthesis II, Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis, superpathway of 5-aminoimidazole ribonucleotide biosynthesis
UniProt: Q8CIH9
Entrez ID: 231327
|
Does Knockout of Zcchc7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Zcchc7
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zcchc7 (zinc finger, CCHC domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TRAMP-dependent tRNA surveillance pathway, biological_process, nuclear mRNA surveillance of mRNA 3'-end processing, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process; MF: RNA binding, metal ion binding, molecular_function, nucleic acid binding, zinc ion binding; CC: TRAMP complex, cytosol, nucleolus, nucleus
Pathways: RNA degradation - Mus musculus (mouse)
UniProt: B1AX39
Entrez ID: 319885
|
Does Knockout of Apex2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Apex2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Apex2 (apurinic/apyrimidinic endonuclease 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, base-excision repair; MF: DNA binding, DNA-(apurinic or apyrimidinic site) endonuclease activity, catalytic activity, double-stranded DNA 3'-5' DNA exonuclease activity, endonuclease activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, phosphoric diester hydrolase activity, zinc ion binding; CC: cytoplasm, fibrillar center, mitochondrial inner membrane, mitochondrion, nucleoplasm, nucleus
Pathways: Base excision repair - Mus musculus (mouse)
UniProt: Q68G58
Entrez ID: 77622
|
Does Knockout of Ifi209 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Ifi209
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ifi209 (interferon activated gene 209)
Type: protein-coding
Summary: Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Acts upstream of or within cellular response to interferon-beta. Predicted to be located in nucleolus. Predicted to be active in cytosol and nucleoplasm. Is expressed in embryo mesenchyme. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: activation of innate immune response, cellular response to interferon-beta; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8BV49
Entrez ID: 236312
|
Does Knockout of Akr1c20 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Akr1c20
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Akr1c20 (aldo-keto reductase family 1, member C20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: daunorubicin metabolic process, doxorubicin metabolic process, progesterone metabolic process, prostaglandin metabolic process, response to estrogen, response to xenobiotic stimulus, steroid biosynthetic process; MF: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity, 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity, Delta4-3-oxosteroid 5beta-reductase activity, alcohol dehydrogenase (NADP+) activity, aldose reductase (NADPH) activity, all-trans-retinol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, bile acid binding, carboxylic acid binding, chlordecone reductase activity, geranylgeranyl reductase activity, ketoreductase activity, ketosteroid monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, prostaglandin D2 11-ketoreductase activity, prostaglandin H2 endoperoxidase reductase activity, retinal dehydrogenase (NAD+) activity, testosterone dehydrogenase (NADP+) activity, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Arachidonate metabolism, Bile acid and bile salt metabolism, Drug ADME, Fatty acid metabolism, Metabolism, Metabolism of fat-soluble vitamins, Metabolism of lipids, Metabolism of steroids, Metabolism of vitamins and cofactors, Prednisone ADME, RA biosynthesis pathway, Retinoid metabolism and transport, Sensory Perception, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, Synthesis of Prostaglandins (PG) and Thromboxanes (TX), Synthesis of bile acids and bile salts, Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Visual phototransduction
UniProt: Q8VC77, Q9CZU0, A0A1Y7VMC8
Entrez ID: 116852
|
Does Knockout of Ccdc61 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Ccdc61
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ccdc61 (coiled-coil domain containing 61)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, centriole assembly, mitotic spindle assembly; MF: identical protein binding, microtubule binding; CC: cell projection, centriolar satellite, centriolar subdistal appendage, centrosome, ciliary basal body, cytoplasm, cytoskeleton, microtubule organizing center
Pathways:
UniProt: Q3UJV1
Entrez ID: 232933
|
Does Knockout of Kcnh5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Kcnh5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kcnh5 (potassium voltage-gated channel, subfamily H (eag-related), member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, regulation of G2/M transition of mitotic cell cycle, regulation of membrane potential, transmembrane transport; MF: calmodulin binding, delayed rectifier potassium channel activity, monoatomic ion channel activity, potassium channel activity, protein-containing complex binding, transmembrane transporter binding, voltage-gated potassium channel activity; CC: cell surface, membrane, monoatomic ion channel complex, plasma membrane, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: Q920E3
Entrez ID: 238271
|
Does Knockout of Mir2137 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Mir2137
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mir2137 (microRNA 2137)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100316779
|
Does Knockout of Zbtb37 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Zbtb37
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Zbtb37 (zinc finger and BTB domain containing 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: F7ALN1, Q8C3U9, H3BJ23
Entrez ID: 240869
|
Does Knockout of Ankar in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Ankar
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ankar (ankyrin and armadillo repeat containing)
Type: protein-coding
Summary: Predicted to be located in membrane. Orthologous to human ANKAR (ankyrin and armadillo repeat containing). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A2RT91
Entrez ID: 319695
|
Does Knockout of Dyrk3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Dyrk3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dyrk3 (dual-specificity tyrosine phosphorylation regulated kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, erythrocyte differentiation, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of apoptotic process, nuclear speck organization, organelle disassembly, positive regulation of cell cycle G2/M phase transition, protein phosphorylation, regulation of TORC1 signaling, regulation of cellular response to stress, stress granule disassembly; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: centrosome, cytoplasm, cytoplasmic stress granule, cytoskeleton, cytosol, nuclear speck, nucleoplasm, nucleus, pericentriolar material
Pathways:
UniProt: Q922Y0
Entrez ID: 226419
|
Does Knockout of Kcnh1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Kcnh1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kcnh1 (potassium voltage-gated channel, subfamily H (eag-related), member 1)
Type: protein-coding
Summary: Enables delayed rectifier potassium channel activity and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in potassium ion transmembrane transport; regulation of presynaptic cytosolic calcium ion concentration; and regulation of synaptic vesicle exocytosis. Located in plasma membrane. Is active in parallel fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to calcium ion, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, regulation of cell population proliferation, regulation of membrane potential, regulation of presynaptic cytosolic calcium ion concentration, regulation of presynaptic membrane potential, regulation of synaptic vesicle exocytosis, startle response, transmembrane transport; MF: 14-3-3 protein binding, calmodulin binding, cyclic nucleotide binding, delayed rectifier potassium channel activity, identical protein binding, lipid binding, monoatomic ion channel activity, phosphatidylinositol bisphosphate binding, potassium channel activity, protein kinase binding, protein-containing complex binding, transmembrane transporter binding, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated potassium channel activity; CC: axolemma, axon, cell projection, cell surface, dendrite, early endosome membrane, endosome, membrane, monoatomic ion channel complex, neuronal cell body, nuclear inner membrane, nucleus, parallel fiber to Purkinje cell synapse, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynaptic density membrane, postsynaptic membrane, potassium channel complex, presynaptic membrane, synapse, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: Q60603
Entrez ID: 16510
|
Does Knockout of Gm1995 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Gm1995
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gm1995 (predicted gene 1995)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Galnt12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Galnt12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Galnt12 (polypeptide N-acetylgalactosaminyltransferase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, molecular_function, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, Mucin type O-glycan biosynthesis - Mus musculus (mouse), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification
UniProt: Q8BGT9
Entrez ID: 230145
|
Does Knockout of Prl8a2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Prl8a2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Prl8a2 (prolactin family 8, subfamily a, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, maternal process involved in female pregnancy, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to hypoxia, response to nutrient levels; MF: hormone activity, prolactin receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: O54832, O35258, A0A286YDW1
Entrez ID: 13529
|
Does Knockout of S100pbp in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,411
|
Knockout
|
S100pbp
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: S100pbp (S100P binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium-dependent protein binding, molecular_function; CC: cytosol, nuclear speck, nucleus
Pathways:
UniProt: Q9D5K4
Entrez ID: 74648
|
Does Knockout of Snf8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Snf8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Snf8 (SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: early endosome to late endosome transport, endocytic recycling, macroautophagy, multivesicular body assembly, multivesicular body sorting pathway, positive regulation of exosomal secretion, positive regulation of gene expression, positive regulation of protein catabolic process, protein transport, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, regulation of protein catabolic process, regulation of protein complex stability, regulation of transcription by RNA polymerase II; MF: channel regulator activity, lipid binding, protein homodimerization activity; CC: ESCRT II complex, cytoplasm, cytosol, endosome, endosome membrane, late endosome membrane, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, recycling endosome, transcription regulator complex
Pathways: Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9CZ28
Entrez ID: 27681
|
Does Knockout of Igf1r in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Igf1r
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Igf1r (insulin-like growth factor I receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adrenal gland development, amyloid-beta clearance, animal organ morphogenesis, axonogenesis, brain development, cell surface receptor protein tyrosine kinase signaling pathway, cellular response to amyloid-beta, cellular response to glucose stimulus, cellular response to insulin stimulus, cellular response to insulin-like growth factor stimulus, cellular response to transforming growth factor beta stimulus, cerebellum development, dendritic spine maintenance, epidermis development, establishment of cell polarity, estrous cycle, exocrine pancreas development, immune response, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, male sex determination, mammary gland development, negative regulation of MAPK cascade, negative regulation of apoptotic process, negative regulation of cholangiocyte apoptotic process, negative regulation of hepatocyte apoptotic process, negative regulation of muscle cell apoptotic process, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, neuron projection development, positive regulation of DNA metabolic process, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of axon regeneration, positive regulation of cell cycle process, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of cytokinesis, positive regulation of developmental growth, positive regulation of meiotic cell cycle, positive regulation of mitotic nuclear division, positive regulation of osteoblast proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein-containing complex disassembly, positive regulation of smooth muscle cell proliferation, positive regulation of steroid hormone biosynthetic process, postsynaptic modulation of chemical synaptic transmission, prostate gland epithelium morphogenesis, protein autophosphorylation, regulation of JNK cascade, response to L-glutamate, response to ethanol, transcytosis; MF: ATP binding, G-protein alpha-subunit binding, identical protein binding, insulin binding, insulin receptor activity, insulin receptor binding, insulin receptor substrate binding, insulin-like growth factor I binding, insulin-like growth factor binding, insulin-like growth factor receptor activity, kinase activity, nucleotide binding, phosphatidylinositol 3-kinase binding, protein binding, protein kinase activity, protein transporter activity, protein tyrosine kinase activity, protein-containing complex binding, structural molecule activity, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: T-tubule, alphav-beta3 integrin-IGF-1-IGF1R complex, axon, caveola, cilium, glutamatergic synapse, insulin receptor complex, membrane, neuronal cell body, nucleolus, plasma membrane, postsynapse, protein kinase complex, receptor complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adherens junction - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), ESR-mediated signaling, Endocytosis - Mus musculus (mouse), Extra-nuclear estrogen signaling, Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Glioma - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), IGF1R signaling cascade, IRS-related events triggered by IGF1R, Long-term depression - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), SHC-related events triggered by IGF1R, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q60751
Entrez ID: 16001
|
Does Knockout of Psma2 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Psma2
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Psma2 (proteasome subunit alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, response to virus, ubiquitin-dependent protein catabolic process; CC: P-body, cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P49722
Entrez ID: 19166
|
Does Knockout of Vmn1r86 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Vmn1r86
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Vmn1r86 (vomeronasal 1 receptor 86)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BR71, L7N213
Entrez ID: 100312473
|
Does Knockout of Brwd3 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Brwd3
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Brwd3 (bromodomain and WD repeat domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, regulation of cell shape, regulation of transcription by RNA polymerase II
Pathways:
UniProt: A2AHJ4
Entrez ID: 382236
|
Does Knockout of Ech1 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Ech1
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Ech1 (enoyl coenzyme A hydratase 1, peroxisomal)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process; MF: catalytic activity, delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity, isomerase activity; CC: cytoplasm, mitochondrion, peroxisome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization
UniProt: O35459
Entrez ID: 51798
|
Does Knockout of Mir219b in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Mir219b
|
cell cycle progression
|
breast epithelium
|
Gene: Mir219b (microRNA 219b)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102466839
|
Does Knockout of Tsku in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Tsku
|
response to virus
|
Microglial Cell Line
|
Gene: Tsku (tsukushi, small leucine rich proteoglycan)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, anterior commissure morphogenesis, camera-type eye development, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, ciliary body morphogenesis, corpus callosum morphogenesis, energy homeostasis, hippocampus development, inner ear receptor cell stereocilium organization, lateral ventricle development, negative regulation of Wnt signaling pathway, negative regulation of myofibroblast differentiation, negative regulation of neuron projection development, negative regulation of transforming growth factor beta1 production, nervous system development, positive regulation of hair cycle, regulation of gene expression, wound healing; MF: cytokine binding, protein binding, signaling receptor activity, transforming growth factor beta binding; CC: extracellular region, extracellular space, plasma membrane
Pathways:
UniProt: Q8CBR6
Entrez ID: 244152
|
Does Knockout of Atp6v0d2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Atp6v0d2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Atp6v0d2 (ATPase, H+ transporting, lysosomal V0 subunit D2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, vacuolar acidification, vacuolar transport; CC: apical plasma membrane, early endosome, endosome, membrane, plasma membrane proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain, vacuolar proton-transporting V-type ATPase complex
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q80SY3
Entrez ID: 242341
|
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