prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Zp1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Zp1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zp1 (zona pellucida glycoprotein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, prevention of polyspermy, single fertilization; MF: acrosin binding, structural constituent of egg coat; CC: egg coat, extracellular matrix, extracellular region, membrane, plasma membrane
Pathways: Fertilization, Interaction With Cumulus Cells And The Zona Pellucida, Reproduction
UniProt: Q62005
Entrez ID: 22786
|
Does Knockout of Slc35e4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Slc35e4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Slc35e4 (solute carrier family 35, member E4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, membrane
Pathways:
UniProt: Q8K3D6
Entrez ID: 103710
|
Does Knockout of Myf6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Myf6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Myf6 (myogenic factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, muscle organ development, muscle tissue morphogenesis, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of myoblast differentiation, positive regulation of skeletal muscle fiber development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal muscle cell differentiation, skeletal muscle tissue development, skeletal muscle tissue regeneration, somitogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: cytosol, mitotic spindle, nucleoplasm, nucleus
Pathways: Developmental Biology, Myogenesis
UniProt: P15375
Entrez ID: 17878
|
Does Knockout of Serpina3g in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Serpina3g
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Serpina3g (serine (or cysteine) peptidase inhibitor, clade A, member 3G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, apoptotic process, immune system process, response to cytokine, response to peptide hormone; MF: cysteine-type endopeptidase inhibitor activity, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: cytoplasm, extracellular space, nucleus
Pathways:
UniProt: Q5I2A0
Entrez ID: 20715
|
Does Knockout of Ly6a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Ly6a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ly6a (lymphocyte antigen 6 family member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine receptor signaling pathway, response to bacterium; MF: acetylcholine receptor binding, acetylcholine receptor inhibitor activity, protein binding; CC: external side of plasma membrane, membrane, plasma membrane, side of membrane, synapse
Pathways:
UniProt: P05533
Entrez ID: 110454
|
Does Knockout of Fndc11 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Fndc11
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Fndc11 (fibronectin type III domain containing 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q80WB0
Entrez ID: 332713
|
Does Knockout of Bora in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Bora
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Bora (bora, aurora kinase A activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, regulation of mitotic nuclear division, regulation of mitotic spindle organization, regulation of protein localization; MF: protein kinase binding; CC: cytoplasm, meiotic spindle, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q8BS90
Entrez ID: 77744
|
Does Knockout of Slc39a4 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Slc39a4
|
phagocytosis
|
macrophage
|
Gene: Slc39a4 (solute carrier family 39 (zinc transporter), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, cellular response to zinc ion starvation, intracellular monoatomic cation homeostasis, intracellular zinc ion homeostasis, metal ion transport, monoatomic ion transport, transmembrane transport, zinc ion import across plasma membrane, zinc ion transmembrane transport, zinc ion transport; MF: identical protein binding, metal ion binding, metal ion transmembrane transporter activity, monoatomic cation:bicarbonate symporter activity, zinc ion binding, zinc ion sensor activity, zinc ion sequestering activity, zinc ion transmembrane transporter activity; CC: apical plasma membrane, cytoplasmic vesicle, endosome, membrane, plasma membrane, recycling endosome membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Metal ion SLC transporters, Mineral absorption - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), SLC-mediated transmembrane transport, Transport of small molecules, Zinc influx into cells by the SLC39 gene family, Zinc transporters
UniProt: Q78IQ7
Entrez ID: 72027
|
Does Knockout of Oprl1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Oprl1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Oprl1 (opioid receptor-like 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017].
Gene Ontology: BP: G protein-coupled opioid receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, behavioral response to cocaine, behavioral response to ethanol, behavioral response to nicotine, calcium-mediated signaling, cellular response to ethanol, conditioned place preference, eating behavior, negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, negative regulation of blood pressure, negative regulation of cAMP/PKA signal transduction, neuron-neuron synaptic transmission, neuropeptide signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of urine volume, regulation of locomotor rhythm, regulation of synaptic transmission, GABAergic, response to ethanol, response to peptide, sensory perception of pain, signal transduction; MF: G protein-coupled opioid receptor activity, G protein-coupled receptor activity, neuropeptide binding, nociceptin receptor activity; CC: cytoplasmic vesicle, membrane, neuron projection, plasma membrane, synaptic membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: P35377
Entrez ID: 18389
|
Does Knockout of Epn3 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Epn3
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Epn3 (epsin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: EH domain binding, clathrin binding, lipid binding, phospholipid binding; CC: cell cortex, clathrin vesicle coat, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, endosome, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q91W69
Entrez ID: 71889
|
Does Knockout of Astn1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Astn1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Astn1 (astrotactin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell migration, cell-cell adhesion, locomotory behavior, neuron cell-cell adhesion, neuron migration; CC: clathrin-coated vesicle, cytoplasmic vesicle, endosome, external side of plasma membrane, membrane, perikaryon, plasma membrane
Pathways:
UniProt: Q61137
Entrez ID: 11899
|
Does Knockout of Clic5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Clic5
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Clic5 (chloride intracellular channel 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: auditory receptor cell stereocilium organization, chloride transmembrane transport, chloride transport, diet induced thermogenesis, epidermal cell differentiation, inner ear receptor cell stereocilium organization, intracellular protein localization, monoatomic ion transmembrane transport, monoatomic ion transport, neuromuscular process controlling balance, response to dietary excess, sensory perception of sound, visual perception; MF: chloride channel activity, oxidoreductase activity, protein binding; CC: Golgi apparatus, actin cytoskeleton, apical plasma membrane, cell cortex, cell projection, centrosome, chloride channel complex, cytoplasm, cytoskeleton, membrane, mitochondrial inner membrane, mitochondrion, monoatomic ion channel complex, plasma membrane, stereocilium, stereocilium base, stereocilium bundle
Pathways:
UniProt: Q8BXK9
Entrez ID: 224796
|
Does Knockout of Mgst3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Mgst3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mgst3 (microsomal glutathione S-transferase 3)
Type: protein-coding
Summary: Predicted to enable several functions, including glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Predicted to be involved in leukotriene biosynthetic process and prostanoid metabolic process. Predicted to be located in mitochondrial outer membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Is expressed in several structures, including alimentary system; integumental system; liver; nervous system; and sensory organ. Orthologous to human MGST3 (microsomal glutathione S-transferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: arachidonate metabolic process, cellular oxidant detoxification, leukotriene biosynthetic process, leukotriene metabolic process, lipid metabolic process, prostanoid metabolic process; MF: glutathione peroxidase activity, glutathione transferase activity, identical protein binding, leukotriene-C4 synthase activity, lyase activity, oxidoreductase activity, transferase activity; CC: endoplasmic reticulum, membrane, mitochondrial outer membrane, mitochondrion, nuclear envelope
Pathways: Aflatoxin activation and detoxification, Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: Q9CPU4
Entrez ID: 66447
|
Does Knockout of Nlrp4g in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Nlrp4g
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Nlrp4g (NLR family, pyrin domain containing 4G)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Foxd3 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Foxd3
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Foxd3 (forkhead box D3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, anatomical structure morphogenesis, cell differentiation, cellular response to leukemia inhibitory factor, embryonic placenta development, in utero embryonic development, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, trophectodermal cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, nucleus, transcription regulator complex
Pathways:
UniProt: Q61060
Entrez ID: 15221
|
Does Knockout of Birc7 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Birc7
|
cell cycle progression
|
breast epithelium
|
Gene: Birc7 (baculoviral IAP repeat-containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, lens development in camera-type eye, negative regulation of apoptotic process, negative regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of JNK cascade, positive regulation of protein ubiquitination, protein ubiquitination, regulation of apoptotic process, regulation of cell cycle, regulation of cell population proliferation, regulation of natural killer cell apoptotic process; MF: cysteine-type endopeptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, metal ion binding, peptidase inhibitor activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Golgi apparatus, centrosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Apoptosis - multiple species - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: A2AWP0
Entrez ID: 329581
|
Does Knockout of Isl2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Isl2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Isl2 (insulin related protein 2 (islet 2))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, negative regulation of neuron differentiation, neuron development, neuron fate commitment, neuron fate specification, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, retinal ganglion cell axon guidance, spinal cord motor neuron cell fate specification, visceral motor neuron differentiation; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q9CXV0
Entrez ID: 104360
|
Does Knockout of Sema6c in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Sema6c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sema6c (sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell differentiation, negative chemotaxis, negative regulation of axon extension, nervous system development, neural crest cell migration, positive regulation of cell migration, semaphorin-plexin signaling pathway; MF: chemorepellent activity, semaphorin receptor binding; CC: cell surface, cytoplasm, membrane, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q9WTM3
Entrez ID: 20360
|
Does Knockout of Inpp5k in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Inpp5k
|
cell proliferation
|
Regulatory T cell
|
Gene: Inpp5k (inositol polyphosphate 5-phosphatase K)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to cAMP, cellular response to epidermal growth factor stimulus, cellular response to hormone stimulus, cellular response to insulin stimulus, cellular response to oxygen-containing compound, cellular response to tumor necrosis factor, glucose homeostasis, host-mediated suppression of viral transcription, in utero embryonic development, lipid metabolic process, negative regulation of D-glucose transmembrane transport, negative regulation of DNA-templated transcription, negative regulation of RNA biosynthetic process, negative regulation of calcium ion transport, negative regulation of dephosphorylation, negative regulation of glycogen biosynthetic process, negative regulation of insulin receptor signaling pathway, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of protein targeting to membrane, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, negative regulation of stress fiber assembly, phosphatidylinositol dephosphorylation, positive regulation of DNA-templated transcription, positive regulation of renal water transport, positive regulation of urine volume, protein localization to plasma membrane, regulation of glycogen biosynthetic process, regulation of transport, response to insulin, ruffle assembly; MF: hydrolase activity, inositol bisphosphate phosphatase activity, inositol trisphosphate phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity, inositol-polyphosphate 5-phosphatase activity, phosphatase activity, phosphatidylinositol phosphate 5-phosphatase activity, phosphatidylinositol trisphosphate phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, protein binding, vasopressin receptor activity; CC: cytoplasm, cytosol, endoplasmic reticulum, membrane, neuron projection, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle, ruffle membrane, trans-Golgi network
Pathways: D-<i>myo</i>-inositol (1,4,5)-trisphosphate degradation, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism, Synthesis of PIPs at the plasma membrane, superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism
UniProt: Q8C5L6
Entrez ID: 19062
|
Does Knockout of AB124611 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
AB124611
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: AB124611 (cDNA sequence AB124611)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: A0A0B4J1G2, Z4YNA9
Entrez ID: 382062
|
Does Knockout of Rsad2 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Rsad2
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Rsad2 (radical S-adenosyl methionine domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD4-positive, alpha-beta T cell activation, CD4-positive, alpha-beta T cell differentiation, defense response to virus, immune system process, innate immune response, negative regulation of protein secretion, negative regulation of viral genome replication, ossification, positive regulation of T-helper 2 cell cytokine production, positive regulation of immune response, positive regulation of toll-like receptor 7 signaling pathway, positive regulation of toll-like receptor 9 signaling pathway, regulation of ossification, response to virus; MF: 4 iron, 4 sulfur cluster binding, catalytic activity, iron-sulfur cluster binding, lyase activity, metal ion binding, protein binding; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, fibrillar center, lipid droplet, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion
Pathways: Hepatitis C - Mus musculus (mouse), Influenza A - Mus musculus (mouse)
UniProt: Q8CBB9
Entrez ID: 58185
|
Does Knockout of Trib1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Trib1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Trib1 (tribbles pseudokinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of JNK cascade, negative regulation of MAPK cascade, negative regulation of lipopolysaccharide-mediated signaling pathway, negative regulation of neutrophil differentiation, negative regulation of smooth muscle cell migration, negative regulation of smooth muscle cell proliferation, negative regulation of transcription by RNA polymerase II, positive regulation of eosinophil differentiation, positive regulation of macrophage differentiation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of MAP kinase activity, response to lipopolysaccharide; MF: ATP binding, RNA polymerase II-specific DNA-binding transcription factor binding, mitogen-activated protein kinase kinase binding, protein kinase activity, protein kinase binding, protein kinase inhibitor activity, transcription regulator inhibitor activity, ubiquitin protein ligase binding, ubiquitin-protein transferase regulator activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8K4K4
Entrez ID: 211770
|
Does Knockout of Plekho1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Plekho1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Plekho1 (pleckstrin homology domain containing, family O member 1)
Type: protein-coding
Summary: Acts upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Located in muscle cell projection membrane and ruffle membrane. Orthologous to human PLEKHO1 (pleckstrin homology domain containing O1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lamellipodium morphogenesis, myoblast fusion, myoblast migration, regulation of cell shape, regulation of myoblast fusion; CC: cytoplasm, membrane, muscle cell projection membrane, nucleus, plasma membrane, ruffle membrane
Pathways:
UniProt: Q9JIY0
Entrez ID: 67220
|
Does Knockout of Zfp428 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Zfp428
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Zfp428 (zinc finger protein 428)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Is expressed in cortical plate. Orthologous to human ZNF428 (zinc finger protein 428). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q8C1M2
Entrez ID: 232969
|
Does Knockout of Npm3 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Npm3
|
phagocytosis
|
macrophage
|
Gene: Npm3 (nucleoplasmin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, rRNA processing, rRNA transcription; MF: RNA binding, chromatin binding, histone binding, protein binding; CC: actin cytoskeleton, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9CPP0
Entrez ID: 18150
|
Does Knockout of Dmrt3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,685
|
Knockout
|
Dmrt3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dmrt3 (doublesex and mab-3 related transcription factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult locomotory behavior, adult walking behavior, cell differentiation, male sex differentiation, regulation of DNA-templated transcription, regulation of odontogenesis of dentin-containing tooth, regulation of transcription by RNA polymerase II, sex differentiation, transmission of nerve impulse, ventral spinal cord interneuron specification; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q80WT2
Entrez ID: 240590
|
Does Knockout of Fzd10 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Fzd10
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fzd10 (frizzled class receptor 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Wnt signaling pathway, canonical Wnt signaling pathway, cell surface receptor signaling pathway, non-canonical Wnt signaling pathway, positive regulation of JNK cascade, regulation of actin cytoskeleton organization, signal transduction; MF: G protein-coupled receptor activity, Wnt receptor activity, Wnt-protein binding, transmembrane signaling receptor activity; CC: cell surface, cytoplasm, extracellular space, membrane, nucleoplasm, plasma membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q8BKG4
Entrez ID: 93897
|
Does Knockout of Jak2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Jak2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Jak2 (Janus kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, activation of Janus kinase activity, adaptive immune response, apoptotic signaling pathway, axon regeneration, cell adhesion, cell differentiation, cell surface receptor signaling pathway via JAK-STAT, cellular response to dexamethasone stimulus, cellular response to interleukin-3, cellular response to lipopolysaccharide, cellular response to steroid hormone stimulus, chromatin organization, chromatin remodeling, collagen-activated signaling pathway, cytokine-mediated signaling pathway, defense response to symbiont, enzyme-linked receptor protein signaling pathway, erythrocyte differentiation, erythropoietin-mediated signaling pathway, extrinsic apoptotic signaling pathway, granulocyte-macrophage colony-stimulating factor signaling pathway, growth hormone receptor signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, hormone-mediated signaling pathway, immune response, immune system process, innate immune response, interleukin-12-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-3-mediated signaling pathway, interleukin-5-mediated signaling pathway, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to oxidative stress, lipopolysaccharide-mediated signaling pathway, mammary gland epithelium development, microglial cell activation, modulation of chemical synaptic transmission, myeloid cell differentiation, negative regulation of 3'-UTR-mediated mRNA stabilization, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell population proliferation, negative regulation of cell-cell adhesion, negative regulation of cytokine production involved in inflammatory response, negative regulation of growth hormone receptor signaling pathway, negative regulation of neuron apoptotic process, nuclear receptor-mediated mineralocorticoid signaling pathway, platelet-derived growth factor receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of MHC class II biosynthetic process, positive regulation of NK T cell proliferation, positive regulation of SMAD protein signal transduction, positive regulation of T cell proliferation, positive regulation of T-helper 17 type immune response, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, positive regulation of cell activation, positive regulation of cell differentiation, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell-substrate adhesion, positive regulation of cold-induced thermogenesis, positive regulation of cytosolic calcium ion concentration, positive regulation of epithelial cell apoptotic process, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, positive regulation of growth hormone receptor signaling pathway, positive regulation of insulin secretion, positive regulation of interleukin-1 beta production, positive regulation of interleukin-17 production, positive regulation of intracellular signal transduction, positive regulation of leukocyte proliferation, positive regulation of natural killer cell proliferation, positive regulation of nitric oxide biosynthetic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of platelet activation, positive regulation of platelet aggregation, positive regulation of protein import into nucleus, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of vascular associated smooth muscle cell proliferation, post-embryonic hemopoiesis, post-translational protein modification, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autophosphorylation, regulation of T cell activation, regulation of apoptotic process, regulation of inflammatory response, regulation of leukocyte cell-cell adhesion, regulation of nitric oxide biosynthetic process, regulation of postsynapse to nucleus signaling pathway, response to antibiotic, response to granulocyte macrophage colony-stimulating factor, response to hydroperoxide, response to interleukin-12, response to oxidative stress, response to tumor necrosis factor, signal transduction, symbiont-induced defense-related programmed cell death, thrombopoietin-mediated signaling pathway, tumor necrosis factor-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: ATP binding, SH2 domain binding, acetylcholine receptor binding, cytokine receptor binding, growth hormone receptor binding, heme binding, histone H3Y41 kinase activity, histone binding, identical protein binding, insulin receptor substrate binding, interleukin-12 receptor binding, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, peptide hormone receptor binding, phosphatidylinositol 3-kinase binding, protein binding, protein kinase activity, protein kinase binding, protein tyrosine kinase activity, signaling receptor activator activity, signaling receptor binding, transferase activity, type 1 angiotensin receptor binding; CC: caveola, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endomembrane system, euchromatin, extrinsic component of cytoplasmic side of plasma membrane, extrinsic component of plasma membrane, focal adhesion, glutamatergic synapse, granulocyte macrophage colony-stimulating factor receptor complex, interleukin-12 receptor complex, interleukin-23 receptor complex, membrane, membrane raft, nucleoplasm, nucleus, plasma membrane, postsynapse
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Cyclin D associated events in G1, Cytokine Signaling in Immune system, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Erythropoietin activates RAS, Factors involved in megakaryocyte development and platelet production, G1 Phase, Growth hormone receptor signaling, Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), IFNG signaling activates MAPKs, IL-6-type cytokine receptor ligand interactions, Immune System, Inactivation of CSF3 (G-CSF) signaling, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, Interleukin receptor SHC signaling, Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-2 family signaling, Interleukin-20 family signaling, Interleukin-23 signaling, Interleukin-27 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-35 Signalling, Interleukin-4 and Interleukin-13 signaling, Interleukin-6 family signaling, Interleukin-6 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK family signaling cascades, MAPK1 (ERK2) activation, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, Mitotic G1 phase and G1/S transition, Necroptosis - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin receptor signaling, Prolactin signaling pathway - Mus musculus (mouse), RAF activation, RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Regulation of IFNG signaling, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by Erythropoietin, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q62120
Entrez ID: 16452
|
Does Knockout of Ssbp1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Ssbp1
|
cell cycle progression
|
breast epithelium
|
Gene: Ssbp1 (single-stranded DNA binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, mitochondrion organization, positive regulation of mitochondrial DNA replication, protein homotetramerization; MF: DNA binding, chromatin binding, enzyme activator activity, identical protein binding, protein homodimerization activity, single-stranded DNA binding; CC: mitochondrial nucleoid, mitochondrion
Pathways: DNA Replication, DNA replication - Mus musculus (mouse), Homologous recombination - Mus musculus (mouse), Metabolism of proteins, Mismatch repair - Mus musculus (mouse), Mitochondrial protein degradation, Strand-asynchronous mitochondrial DNA replication
UniProt: Q9CYR0
Entrez ID: 381760
|
Does Knockout of Gm9758 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Gm9758
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gm9758 (predicted gene 9758)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q80ZT2
Entrez ID: 381714
|
Does Knockout of Anks1 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Anks1
|
response to bacteria
|
renal medulla cell line
|
Gene: Anks1 (ankyrin repeat and SAM domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ephrin receptor signaling pathway, negative regulation of ubiquitin-dependent protein catabolic process, neuron remodeling, regulation of ephrin receptor signaling pathway, substrate-dependent cell migration; MF: ephrin receptor binding; CC: cell projection, cytoplasm, cytosol, neuron projection, nucleoplasm
Pathways:
UniProt: P59672
Entrez ID: 224650
|
Does Knockout of Vmn2r10 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Vmn2r10
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Vmn2r10 (vomeronasal 2, receptor 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: O35204, K7N621, A0A3B2WCF2
Entrez ID: 22307
|
Does Knockout of Plb1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Plb1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Plb1 (phospholipase B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: diacylglycerol catabolic process, lipid metabolic process, phosphatidylcholine catabolic process, phosphatidylethanolamine catabolic process, phosphatidylglycerol catabolic process, phospholipid metabolic process, positive regulation of acrosome reaction, retinol metabolic process, triglyceride catabolic process; MF: calcium-independent phospholipase A2 activity, hydrolase activity, hydrolase activity, acting on ester bonds, lipase activity, phosphatidylcholine lysophospholipase activity, phospholipase A2 activity, phospholipase activity, retinyl-palmitate esterase activity, triacylglycerol lipase activity; CC: apical plasma membrane, brush border membrane, membrane, plasma membrane
Pathways: Acyl chain remodelling of PC, Arachidonic acid metabolism - Mus musculus (mouse), Ether lipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Metabolism, Metabolism of fat-soluble vitamins, Metabolism of lipids, Metabolism of vitamins and cofactors, Phospholipid metabolism, Retinoid metabolism and transport, Sensory Perception, Visual phototransduction, Vitamin digestion and absorption - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), phospholipases
UniProt: Q3TTY0
Entrez ID: 665270
|
Does Knockout of Mir3072 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Mir3072
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mir3072 (microRNA 3072)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100499517
|
Does Knockout of Atp6v0d2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Atp6v0d2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Atp6v0d2 (ATPase, H+ transporting, lysosomal V0 subunit D2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, vacuolar acidification, vacuolar transport; CC: apical plasma membrane, early endosome, endosome, membrane, plasma membrane proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain, vacuolar proton-transporting V-type ATPase complex
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q80SY3
Entrez ID: 242341
|
Does Knockout of Fbxo24 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Fbxo24
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Fbxo24 (F-box protein 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axoneme assembly, biological_process, chromatin organization, cilium organization, mRNA splicing, via spliceosome, mitochondrion organization, piRNA processing, protein catabolic process, single fertilization, spermatogenesis; MF: molecular_function, protein binding; CC: SCF ubiquitin ligase complex, cellular_component
Pathways:
UniProt: Q9D417
Entrez ID: 71176
|
Does Knockout of Asmt in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Asmt
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Asmt (acetylserotonin O-methyltransferase)
Type: protein-coding
Summary: This gene belongs to the methyltransferase superfamily and is located in the pseudoautosomal region (PAR) of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin and is abundant in the pineal gland. Two amino acid substitutions (R78G and R242C) are present in the encoded protein derived from the reference strain, C57BL/6J, and this protein shows low enzyme activity relative to the protein derived from other strains. [provided by RefSeq, May 2015].
Gene Ontology: BP: lipid metabolic process, melatonin biosynthetic process, methylation, negative regulation of male gonad development; MF: O-methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, acetylserotonin O-methyltransferase activity, identical protein binding, methyltransferase activity, protein dimerization activity, protein homodimerization activity, transferase activity
Pathways: Metabolism, Metabolism of amine-derived hormones, Metabolism of amino acids and derivatives, Serotonin and melatonin biosynthesis, Tryptophan metabolism - Mus musculus (mouse), biosynthesis of serotonin and melatonin, serotonin and melatonin biosynthesis
UniProt: D3KU66
Entrez ID: 107626
|
Does Knockout of Supt7l in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Supt7l
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Supt7l (SPT7-like, STAGA complex gamma subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of protein location in nucleus, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing; MF: protein heterodimerization activity, transcription coactivator activity; CC: SAGA complex, nucleoplasm, nucleus
Pathways:
UniProt: Q9CZV5
Entrez ID: 72195
|
Does Knockout of Pcdh15 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Pcdh15
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcdh15 (protocadherin 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle assembly, actin filament organization, adult walking behavior, auditory receptor cell stereocilium organization, cell adhesion, detection of mechanical stimulus involved in equilibrioception, detection of mechanical stimulus involved in sensory perception of sound, equilibrioception, homophilic cell adhesion via plasma membrane adhesion molecules, inner ear auditory receptor cell differentiation, inner ear development, inner ear receptor cell stereocilium organization, locomotory behavior, morphogenesis of an epithelium, multicellular organism growth, non-motile cilium assembly, photoreceptor cell maintenance, response to calcium ion, righting reflex, sensory perception of light stimulus, sensory perception of sound, startle response, visual perception; MF: calcium ion binding, cell adhesion molecule binding, protein binding; CC: cytoplasm, extracellular region, extracellular space, membrane, photoreceptor outer segment, plasma membrane, stereocilium, stereocilium bundle, synapse
Pathways:
UniProt: Q99PJ1
Entrez ID: 11994
|
Does Knockout of Hspg2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Hspg2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hspg2 (perlecan (heparan sulfate proteoglycan 2))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, animal organ morphogenesis, brain development, cardiac muscle tissue development, cartilage development involved in endochondral bone morphogenesis, cell differentiation, chondrocyte differentiation, circulatory system development, embryonic skeletal system morphogenesis, endochondral ossification, extracellular matrix organization, intracellular protein localization, negative regulation of amyloid fibril formation, negative regulation of cell adhesion, negative regulation of cell population proliferation, negative regulation of neuron apoptotic process, positive regulation of endothelial cell proliferation, receptor-mediated endocytosis, smoothened signaling pathway, tissue development; MF: calcium ion binding, collagen V binding, extracellular matrix structural constituent conferring compression resistance, metal ion binding, protease binding, protein binding; CC: Golgi lumen, basement membrane, extracellular matrix, extracellular region
Pathways: ECM-receptor interaction - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse)
UniProt: Q05793
Entrez ID: 15530
|
Does Knockout of Phospho2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Phospho2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Phospho2 (phosphatase, orphan 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, metal ion binding, phosphatase activity, pyridoxal phosphatase activity
Pathways: Vitamin B6 metabolism - Mus musculus (mouse)
UniProt: Q9D9M5
Entrez ID: 73373
|
Does Knockout of Ugt2a2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Ugt2a2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ugt2a2 (UDP glucuronosyltransferase 2 family, polypeptide A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid metabolic process, lipid metabolic process, response to symbiont, xenobiotic metabolic process; MF: UDP-glycosyltransferase activity, glucuronosyltransferase activity, glycosyltransferase activity, transferase activity
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), Aspirin ADME, Bile secretion - Mus musculus (mouse), Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug ADME, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Glucuronidation, Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pentose and glucuronate interconversions - Mus musculus (mouse), Phase II - Conjugation of compounds, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse)
UniProt: Q6PDD0
Entrez ID: 552899
|
Does Knockout of Slc6a12 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Slc6a12
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc6a12 (solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, gamma-aminobutyric acid transport, glycine betaine transport, intracellular water homeostasis, monocarboxylic acid transport, neurotransmitter transport, sodium ion transmembrane transport; MF: gamma-aminobutyric acid:sodium:chloride symporter activity, monocarboxylic acid transmembrane transporter activity, symporter activity; CC: basolateral plasma membrane, cell projection, membrane, plasma membrane
Pathways: GABAergic synapse - Mus musculus (mouse), Synaptic vesicle cycle - Mus musculus (mouse)
UniProt: G5E8Z4, Q8VCS9, E9Q5U8, E9PW98, F7AYZ6, F6SJH4, E9PXG1
Entrez ID: 14411
|
Does Knockout of Dffa in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Dffa
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dffa (DNA fragmentation factor, alpha subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic DNA fragmentation, apoptotic process, negative regulation of apoptotic DNA fragmentation, negative regulation of execution phase of apoptosis, positive regulation of apoptotic process, protein folding, regulation of apoptotic process, thymocyte apoptotic process; MF: deoxyribonuclease inhibitor activity, protein binding, protein domain specific binding, protein folding chaperone; CC: chromatin, cytoplasm, cytosol, nucleus, plasma membrane, protein-containing complex
Pathways: Apoptosis - Mus musculus (mouse)
UniProt: O54786
Entrez ID: 13347
|
Does Knockout of Mfap2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Mfap2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mfap2 (microfibrillar-associated protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: embryonic eye morphogenesis, platelet formation, positive regulation of cold-induced thermogenesis, post-embryonic eye morphogenesis; MF: extracellular matrix structural constituent, fibrinogen binding, fibronectin binding, protein binding; CC: extracellular matrix, extracellular region, microfibril
Pathways: Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres
UniProt: P55002
Entrez ID: 17150
|
Does Knockout of Pcdhgb2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Pcdhgb2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pcdhgb2 (protocadherin gamma subfamily B, 2)
Type: protein-coding
Summary: Predicted to be involved in cell adhesion. Located in membrane. Is expressed in brain and cerebral cortex. Orthologous to human PCDHGB2 (protocadherin gamma subfamily B, 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, metal ion binding, protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q91XX7
Entrez ID: 93700
|
Does Knockout of Npy1r in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Npy1r
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Npy1r (neuropeptide Y receptor Y1)
Type: protein-coding
Summary: Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Acts upstream of or within several processes, including feeding behavior; glucose metabolic process; and sensory perception of pain. Predicted to be located in axon and synaptic vesicle. Predicted to be active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and presynaptic membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; immune system; and liver. Used to study obesity. Human ortholog(s) of this gene implicated in amphetamine abuse; cocaine abuse; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human NPY1R (neuropeptide Y receptor Y1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, feeding behavior, glucose metabolic process, locomotory behavior, negative regulation of cytosolic calcium ion concentration, negative regulation of hormone secretion, neuropeptide signaling pathway, outflow tract morphogenesis, peristalsis, positive regulation of cholesterol biosynthetic process, positive regulation of vasoconstriction, regulation of blood pressure, regulation of multicellular organism growth, regulation of presynaptic cytosolic calcium ion concentration, regulation of synaptic vesicle exocytosis, response to morphine, sensory perception of pain, signal transduction, synaptic signaling via neuropeptide; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity, neuropeptide binding, neuropeptide receptor activity, pancreatic polypeptide receptor activity, peptide YY receptor activity; CC: axon, glutamatergic synapse, membrane, neuron projection, neuronal dense core vesicle, plasma membrane, presynaptic membrane, synaptic vesicle
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Regulation of lipolysis in adipocytes - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q04573
Entrez ID: 18166
|
Does Knockout of Pde6g in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Pde6g
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pde6g (phosphodiesterase 6G, cGMP-specific, rod, gamma)
Type: protein-coding
Summary: Predicted to enable spectrin binding activity. Acts upstream of or within positive regulation of G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in photoreceptor outer segment membrane. Is expressed in eye and retina outer nuclear layer. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 57. Orthologous to human PDE6G (phosphodiesterase 6G). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: positive regulation of G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of epidermal growth factor receptor signaling pathway, visual perception; MF: 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cGMP binding, hydrolase activity, protein binding, spectrin binding; CC: photoreceptor outer segment membrane, plasma membrane
Pathways: Activation of the phototransduction cascade, Beta-catenin independent WNT signaling, Ca2+ pathway, Inactivation, recovery and regulation of the phototransduction cascade, Phototransduction - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by WNT, The phototransduction cascade, Visual phototransduction
UniProt: P09174
Entrez ID: 18588
|
Does Knockout of Mpc2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Mpc2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mpc2 (mitochondrial pyruvate carrier 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of insulin secretion involved in cellular response to glucose stimulus, pyruvate decarboxylation to acetyl-CoA, pyruvate import into mitochondria; MF: identical protein binding, pyruvate transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Diabetic cardiomyopathy - Mus musculus (mouse)
UniProt: Q9D023
Entrez ID: 70456
|
Does Knockout of Slc5a10 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Slc5a10
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc5a10 (solute carrier family 5 (sodium/glucose cotransporter), member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate transmembrane transport, fructose transmembrane transport, hexose transmembrane transport, mannose transmembrane transport, monoatomic ion transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: D-glucose:sodium symporter activity, carbohydrate:monoatomic cation symporter activity, fructose:sodium symporter activity, hexose transmembrane transporter activity, mannose:sodium symporter activity, solute:sodium symporter activity, transmembrane transporter activity; CC: apical plasma membrane, membrane, plasma membrane
Pathways: Cellular hexose transport, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q5SWY8
Entrez ID: 109342
|
Does Knockout of Zc3hc1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Zc3hc1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zc3hc1 (zinc finger, C3HC type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, protein ubiquitination; MF: metal ion binding, protein kinase binding, zinc ion binding; CC: nuclear envelope, nuclear membrane, nuclear pore nuclear basket, nucleoplasm, nucleus
Pathways:
UniProt: Q80YV2
Entrez ID: 232679
|
Does Knockout of Efna2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Efna2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Efna2 (ephrin A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, bone remodeling, ephrin receptor signaling pathway, olfactory bulb development, osteoclast differentiation; MF: ephrin receptor binding, protein binding; CC: membrane, neuromuscular junction, perikaryon, plasma membrane, side of membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, MAPK signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Nervous system development, PI3K-Akt signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse)
UniProt: P52801
Entrez ID: 13637
|
Does Knockout of Hoxd8 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Hoxd8
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Hoxd8 (homeobox D8)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; and skeletal system morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; limb bud; and nervous system. Orthologous to human HOXD8 (homeobox D8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anterior/posterior pattern specification, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal system morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: P23463
Entrez ID: 15437
|
Does Knockout of Mir7224 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Mir7224
|
cell cycle progression
|
breast epithelium
|
Gene: Mir7224 (microRNA 7224)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465706
|
Does Knockout of Riox2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Riox2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Riox2 (ribosomal oxygenase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, negative regulation of DNA-templated transcription, regulation of cell population proliferation, ribosome biogenesis; MF: dioxygenase activity, histone H3K36 demethylase activity, histone H3K4 demethylase activity, identical protein binding, metal ion binding, oxidoreductase activity, peptidyl-histidine dioxygenase activity, transcription corepressor activity; CC: cytosol, nucleolus, nucleoplasm, nucleus, transcription regulator complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, HDMs demethylate histones, Metabolism of proteins, Post-translational protein modification, Protein hydroxylation
UniProt: Q8CD15
Entrez ID: 67014
|
Does Knockout of Tas2r139 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Tas2r139
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tas2r139 (taste receptor, type 2, member 139)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse)
UniProt: Q7TQA5
Entrez ID: 353148
|
Does Knockout of Acacb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Acacb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Acacb (acetyl-Coenzyme A carboxylase beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import, acetyl-CoA metabolic process, acyl-CoA metabolic process, energy homeostasis, fatty acid biosynthetic process, fatty acid metabolic process, fatty acid oxidation, intracellular aspartate homeostasis, intracellular glutamate homeostasis, lactic acid secretion, lipid metabolic process, malonyl-CoA biosynthetic process, negative regulation of fatty acid beta-oxidation, negative regulation of fatty acid oxidation, negative regulation of fatty acid transport, negative regulation of intracellular lipid transport, negative regulation of lipid catabolic process, negative regulation of transmembrane transport, pentose-phosphate shunt, positive regulation of heart growth, positive regulation of lipid storage, protein homotetramerization, purine nucleotide metabolic process, regulation of cardiac muscle hypertrophy in response to stress, regulation of glucose metabolic process, response to caloric restriction, response to nutrient, response to nutrient levels, response to xenobiotic stimulus, tricarboxylic acid metabolic process; MF: ATP binding, acetyl-CoA carboxylase activity, biotin binding, catalytic activity, identical protein binding, ligase activity, metal ion binding, nucleotide binding; CC: mitochondrial fatty acid beta-oxidation multienzyme complex, mitochondrial outer membrane, mitochondrion, nucleus
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Biotin transport and metabolism, Carnitine shuttle, Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid metabolism, Glucagon signaling pathway - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Propanoate metabolism - Mus musculus (mouse), Pyruvate metabolism - Mus musculus (mouse), biotin-carboxyl carrier protein assembly
UniProt: E9Q4Z2
Entrez ID: 100705
|
Does Knockout of Zfp873 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Zfp873
|
response to virus
|
Microglial Cell Line
|
Gene: Zfp873 (zinc finger protein 873)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: developmental process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: fibrillar center, microtubule cytoskeleton, nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: A0A1B0GT64, Q3UPB5, Q5BL04, E9PU88, A0A1B0GSL8
Entrez ID: 408062
|
Does Knockout of Galnt10 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Galnt10
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Galnt10 (polypeptide N-acetylgalactosaminyltransferase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, Mucin type O-glycan biosynthesis - Mus musculus (mouse), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification
UniProt: Q6P9S7
Entrez ID: 171212
|
Does Knockout of Csn2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Csn2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Csn2 (casein beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways: Prolactin signaling pathway - Mus musculus (mouse)
UniProt: P10598
Entrez ID: 12991
|
Does Knockout of Gm5447 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Gm5447
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gm5447 (predicted gene 5447)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Fggy in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Fggy
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fggy (FGGY carbohydrate kinase domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, carbohydrate phosphorylation, neuron cellular homeostasis, pentose metabolic process; MF: D-ribulokinase activity, kinase activity, phosphotransferase activity, alcohol group as acceptor, transferase activity
Pathways:
UniProt: A2AJL3
Entrez ID: 75578
|
Does Knockout of Sel1l3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Sel1l3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sel1l3 (sel-1 suppressor of lin-12-like 3 (C. elegans))
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q80TS8
Entrez ID: 231238
|
Does Knockout of P3h3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
P3h3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: P3h3 (prolyl 3-hydroxylase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen biosynthetic process, collagen metabolic process, negative regulation of cell population proliferation, peptidyl-lysine hydroxylation; MF: L-ascorbic acid binding, dioxygenase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, procollagen-proline 3-dioxygenase activity, protein binding; CC: catalytic complex, endoplasmic reticulum
Pathways: Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization
UniProt: Q8CG70
Entrez ID: 14789
|
Does Knockout of Zfp457 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Zfp457
|
phagocytosis
|
macrophage
|
Gene: Zfp457 (zinc finger protein 457)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: membrane, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q7M6X7, L7N1X4, A0A286YD33, A0A286YD11
Entrez ID: 431706
|
Does Knockout of Spns2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Spns2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Spns2 (SPNS lysolipid transporter 2, sphingosine-1-phosphate)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell homeostasis, T cell homeostasis, bone development, lipid transport, lymph node development, lymphocyte homeostasis, lymphocyte migration, regulation of T cell migration, regulation of eye pigmentation, regulation of humoral immune response, sensory perception of sound, sphingolipid metabolic process, sphingosine-1-phosphate receptor signaling pathway, transmembrane transport; MF: sphingolipid transporter activity, transmembrane transporter activity; CC: endosome, endosome membrane, membrane, plasma membrane
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism
UniProt: Q91VM4
Entrez ID: 216892
|
Does Knockout of Defb33 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Defb33
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Defb33 (defensin beta 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response, defense response to bacterium, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q30KN3
Entrez ID: 654453
|
Does Knockout of Golim4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Golim4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Golim4 (golgi integral membrane protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, endosome, endosome membrane, membrane
Pathways:
UniProt: Q8BXA1
Entrez ID: 73124
|
Does Knockout of Osbpl5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Osbpl5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Osbpl5 (oxysterol binding protein-like 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermembrane lipid transfer, lipid transport, phospholipid transport; MF: cholesterol binding, lipid binding, phosphatidylinositol-4-phosphate binding, phosphatidylserine binding, phosphatidylserine transfer activity; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, membrane
Pathways: Acyl chain remodelling of PS, Cholesterol metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism
UniProt: Q9ER64
Entrez ID: 79196
|
Does Knockout of Kcnj16 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Kcnj16
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kcnj16 (potassium inwardly-rectifying channel, subfamily J, member 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of monoatomic ion transmembrane transport, regulation of pH, response to carbon dioxide; MF: inward rectifier potassium channel activity; CC: basolateral plasma membrane, membrane, monoatomic ion channel complex, plasma membrane
Pathways: Activation of G protein gated Potassium channels, Activation of GABAB receptors, G protein gated Potassium channels, GABA B receptor activation, GABA receptor activation, Gastric acid secretion - Mus musculus (mouse), Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Inwardly rectifying K+ channels, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Potassium Channels, Potassium transport channels, Transmission across Chemical Synapses
UniProt: Q9Z307
Entrez ID: 16517
|
Does Knockout of Snx7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Snx7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Snx7 (sorting nexin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, mitophagy, piecemeal microautophagy of the nucleus, positive regulation of autophagosome assembly, protein transport, reticulophagy; MF: lipid binding, phosphatidylinositol binding, protein binding; CC: cytoplasm, early endosome, early endosome membrane, endosome, membrane, phagophore assembly site
Pathways:
UniProt: Q9CY18
Entrez ID: 76561
|
Does Knockout of Tie1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Tie1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tie1 (tyrosine kinase with immunoglobulin-like and EGF-like domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, aortic valve morphogenesis, blood vessel development, branching involved in lymph vessel morphogenesis, branching morphogenesis of an epithelial tube, cell differentiation, cell surface receptor protein tyrosine kinase signaling pathway, heart development, in utero embryonic development, lymphatic endothelial cell differentiation, negative regulation of angiogenesis, negative regulation of cell migration, plasma membrane fusion, positive regulation of angiogenesis, regulation of endothelial cell proliferation, regulation of extracellular matrix assembly, response to retinoic acid, tissue remodeling, vasculogenesis; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: membrane, plasma membrane, receptor complex
Pathways:
UniProt: Q06806
Entrez ID: 21846
|
Does Knockout of AW209491 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
AW209491
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: AW209491 (expressed sequence AW209491)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q91WD4
Entrez ID: 105351
|
Does Knockout of Mttp in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Mttp
|
response to bacteria
|
macrophage
|
Gene: Mttp (microsomal triglyceride transfer protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide 1-phosphate transport, cholesterol homeostasis, cholesterol metabolic process, circadian rhythm, establishment of localization in cell, gene expression, glutamine metabolic process, glycolytic process, intermembrane lipid transfer, lipid metabolic process, lipid transport, lipoprotein metabolic process, lipoprotein transport, low-density lipoprotein particle remodeling, phospholipid transport, plasma lipoprotein particle assembly, protein secretion, response to calcium ion, steroid metabolic process, sterol transport, triglyceride metabolic process, triglyceride transport, very-low-density lipoprotein particle clearance; MF: apolipoprotein binding, ceramide 1-phosphate transfer activity, cholesterol transfer activity, lipid binding, lipid transporter activity, phosphatidylcholine transfer activity, phosphatidylethanolamine transfer activity, phospholipid transfer activity, phospholipid transporter activity, protein binding, protein heterodimerization activity, protein-containing complex binding, triglyceride transfer activity; CC: Golgi apparatus, basolateral plasma membrane, brush border membrane, cytosol, endoplasmic reticulum, microvillus membrane, receptor complex, vesicle
Pathways: Chylomicron assembly, Fat digestion and absorption - Mus musculus (mouse), LDL remodeling, Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Transport of small molecules, VLDL assembly
UniProt: O08601
Entrez ID: 17777
|
Does Knockout of Gna12 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Gna12
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gna12 (guanine nucleotide binding protein, alpha 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho protein signal transduction, Rho-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell differentiation, embryonic digit morphogenesis, in utero embryonic development, intracellular signal transduction, negative regulation of vascular associated smooth muscle cell migration, negative regulation of vascular associated smooth muscle cell proliferation, regulation of TOR signaling, regulation of blood pressure, regulation of cell shape, regulation of fibroblast migration, regulation of proteasomal ubiquitin-dependent protein catabolic process, response to xenobiotic stimulus, signal transduction; MF: D5 dopamine receptor binding, G protein activity, G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, guanyl nucleotide binding, metal ion binding, nucleotide binding, protein phosphatase 2A binding, protein phosphatase activator activity; CC: brush border membrane, cytoplasm, heterotrimeric G-protein complex, lateral plasma membrane, membrane, neuron projection, neuronal cell body, plasma membrane
Pathways: G alpha (12/13) signalling events, GPCR downstream signalling, Hemostasis, Human cytomegalovirus infection - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation, signaling and aggregation, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Sphingolipid signaling pathway - Mus musculus (mouse), Thrombin signalling through proteinase activated receptors (PARs), Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P27600
Entrez ID: 14673
|
Does Knockout of Ttbk2 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Ttbk2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ttbk2 (tau tubulin kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cerebellar granular layer development, cerebellar granule cell precursor tangential migration, cerebellum development, cilium assembly, embryonic brain development, embryonic digit morphogenesis, forebrain development, microtubule cytoskeleton organization, negative regulation of microtubule depolymerization, negative regulation of protein localization, negative regulation of protein localization to microtubule, neural tube development, peptidyl-serine phosphorylation, positive regulation of non-motile cilium assembly, regulation of cell migration, regulation of smoothened signaling pathway, signal transduction, smoothened signaling pathway; MF: ATP binding, kinase activity, kinesin binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, centriole, ciliary basal body, ciliary base, ciliary transition zone, cilium, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton, nucleus
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q3UVR3
Entrez ID: 140810
|
Does Knockout of a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: a (nonagouti)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult feeding behavior, epigenetic programming in the zygotic pronuclei, epigenetic regulation of gene expression, generation of precursor metabolites and energy, hormone-mediated signaling pathway, melanin biosynthetic process, melanosome organization, melanosome transport, pigmentation, positive regulation of melanin biosynthetic process; MF: melanocortin receptor binding, neuropeptide hormone activity, protein binding, signaling receptor binding, type 3 melanocortin receptor binding, type 4 melanocortin receptor binding; CC: extracellular region, extracellular space
Pathways: Melanogenesis - Mus musculus (mouse)
UniProt: Q03288
Entrez ID: 50518
|
Does Knockout of Ptprz1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Ptprz1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ptprz1 (protein tyrosine phosphatase receptor type Z, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonal fasciculation, axonogenesis, hematopoietic progenitor cell differentiation, learning or memory, negative regulation of cell population proliferation, negative regulation of cell-substrate adhesion, negative regulation of dendrite development, negative regulation of neuron apoptotic process, neuron projection development, oligodendrocyte differentiation, peptidyl-tyrosine dephosphorylation, positive regulation of Schwann cell migration, positive regulation of cell migration, positive regulation of dendrite development, positive regulation of fibroblast proliferation, positive regulation of neuron migration, positive regulation of neuron projection development, positive regulation of oligodendrocyte differentiation, regulation of dendrite morphogenesis, regulation of myelination, regulation of oligodendrocyte progenitor proliferation, signal transduction; MF: fibroblast growth factor binding, hydrolase activity, integrin binding, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein tyrosine phosphatase activity; CC: axon, dendrite, dendritic spine, extracellular matrix, extracellular region, extracellular space, filopodium, glutamatergic synapse, growth cone, lamellipodium, membrane, neuronal cell body, perineuronal net, plasma membrane, postsynaptic density membrane, postsynaptic membrane, ruffle membrane, synapse
Pathways: Cytokine Signaling in Immune system, Immune System, MDK and PTN in ALK signaling, Other interleukin signaling, Signal Transduction, Signaling by ALK, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases
UniProt: B9EKR1
Entrez ID: 19283
|
Does Knockout of Tmem9 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Tmem9
|
phagocytosis
|
macrophage
|
Gene: Tmem9 (transmembrane protein 9)
Type: protein-coding
Summary: Involved in positive regulation of canonical Wnt signaling pathway and regulation of protein catabolic process. Predicted to be located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. Is expressed in central nervous system; retina; small intestine; and tooth. Orthologous to human TMEM9 (transmembrane protein 9). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: endosomal lumen acidification, lysosomal lumen acidification, positive regulation of canonical Wnt signaling pathway, protein transport, proton-transporting V-type ATPase complex assembly, regulation of protein catabolic process; CC: endosome, intercellular bridge, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, microtubule cytoskeleton, mitotic spindle, multivesicular body membrane
Pathways:
UniProt: Q9CR23
Entrez ID: 66241
|
Does Knockout of Nlrp10 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 1
| 1,839
|
Knockout
|
Nlrp10
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Nlrp10 (NLR family, pyrin domain containing 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, adaptive immune response, defense response, defense response to fungus, immune system process, inflammatory response, innate immune response, positive regulation of T-helper 1 type immune response, positive regulation of T-helper 17 type immune response, positive regulation of defense response, positive regulation of defense response to bacterium, positive regulation of immune response, positive regulation of inflammatory response, positive regulation of interleukin-1 alpha production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, regulation of inflammatory response; MF: ATP binding, ATP hydrolysis activity, GTPase activity, nucleotide binding; CC: cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane, nuclear membrane, nucleoplasm, plasma membrane
Pathways:
UniProt: Q8CCN1
Entrez ID: 244202
|
Does Knockout of Tdrd6 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Tdrd6
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Tdrd6 (tudor domain containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P granule organization, cell differentiation, germ cell development, oogenesis, piRNA processing, spermatogenesis, spliceosomal snRNP assembly; CC: P granule, chromatoid body, cytoplasm, cytosol, endoplasmic reticulum, ribonucleoprotein complex, synapse
Pathways:
UniProt: P61407
Entrez ID: 210510
|
Does Knockout of Kif1c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,683
|
Knockout
|
Kif1c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kif1c (kinesin family member 1C)
Type: protein-coding
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi apparatus. Is expressed in alimentary system; hindbrain meninges; submandibular gland primordium; telencephalon; and vibrissa. Human ortholog(s) of this gene implicated in spastic ataxia 2. Orthologous to human KIF1C (kinesin family member 1C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anterograde neuronal dense core vesicle transport, microtubule-based movement, retrograde neuronal dense core vesicle transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity; CC: Golgi apparatus, axon, axon cytoplasm, cytoplasm, cytoskeleton, dendrite, kinesin complex, microtubule
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: O35071
Entrez ID: 16562
|
Does Knockout of Elp2 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Elp2
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Elp2 (elongator acetyltransferase complex subunit 2)
Type: protein-coding
Summary: Enables protein kinase binding activity. Acts upstream of or within regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of elongator holoenzyme complex; proteasome complex; and transcription elongation factor complex. Is expressed in central nervous system; liver; and retina nuclear layer. Used to study autism spectrum disorder and intellectual disability. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 58. Orthologous to human ELP2 (elongator acetyltransferase complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: proteasome assembly, regulation of receptor signaling pathway via JAK-STAT, tRNA processing, tRNA wobble uridine modification, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, endopeptidase activator activity, protein binding, protein kinase binding; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleoplasm, nucleus, proteasome complex, transcription elongation factor complex
Pathways:
UniProt: Q91WG4
Entrez ID: 58523
|
Does Knockout of Adk in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Adk
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Adk (adenosine kinase)
Type: protein-coding
Summary: Enables adenosine kinase activity and deoxyadenosine kinase activity. Involved in AMP salvage; GMP salvage; and dAMP salvage. Acts upstream of or within dATP biosynthetic process and purine ribonucleoside salvage. Located in nucleus. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study steatotic liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: AMP salvage, GMP salvage, adenosine metabolic process, dAMP salvage, dATP biosynthetic process, positive regulation of T cell proliferation, positive regulation of cardiac muscle hypertrophy, purine nucleobase metabolic process, purine ribonucleoside metabolic process, purine ribonucleoside salvage, type B pancreatic cell proliferation; MF: ATP binding, adenosine kinase activity, deoxyadenosine kinase activity, kinase activity, metal ion binding, nucleotide binding, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane
Pathways: Drug ADME, Metabolism, Metabolism of nucleotides, Nucleotide salvage, Purine metabolism - Mus musculus (mouse), Purine salvage, Ribavirin ADME, adenine and adenosine salvage VI
UniProt: P55264
Entrez ID: 11534
|
Does Knockout of Rcsd1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Rcsd1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rcsd1 (RCSD domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular hyperosmotic response, protein localization to endosome, retrograde transport, endosome to Golgi, skeletal muscle contraction; MF: actin filament binding, phosphatidylinositol phosphate binding, retromer complex binding; CC: WASH complex, cellular_component, cytosol, early endosome
Pathways:
UniProt: Q3UZA1
Entrez ID: 226594
|
Does Knockout of Vmn1r200 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Vmn1r200
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Vmn1r200 (vomeronasal 1 receptor 200)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BQ12, Q8R281
Entrez ID: 171246
|
Does Knockout of Tarbp2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Tarbp2
|
phagocytosis
|
macrophage
|
Gene: Tarbp2 (TARBP2, RISC loading complex RNA binding subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RISC complex assembly, cytoplasmic pattern recognition receptor signaling pathway, global gene silencing by mRNA cleavage, miRNA processing, multicellular organism growth, negative regulation of cytoplasmic pattern recognition receptor signaling pathway, negative regulation of defense response to virus by host, neural precursor cell proliferation, positive regulation of muscle cell differentiation, positive regulation of translation, positive regulation of viral genome replication, post-transcriptional regulation of gene expression, pre-miRNA processing, protein K63-linked ubiquitination, regulation of miRNA processing, regulation of protein metabolic process, regulation of regulatory ncRNA processing, regulation of siRNA processing, regulation of translation, regulation of viral transcription, regulatory ncRNA-mediated gene silencing, siRNA processing, single fertilization, skeletal muscle tissue regeneration, spermatid development; MF: RNA binding, double-stranded RNA binding, enzyme binding, identical protein binding, miRNA binding, pre-miRNA binding, protein binding, protein homodimerization activity, protein sequestering activity, siRNA binding; CC: RISC complex, RISC-loading complex, cytoplasm, nuclear body, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Gene Silencing by RNA, Gene expression (Transcription), Immune System, Interferon Signaling, MicroRNA (miRNA) biogenesis, PKR-mediated signaling, Small interfering RNA (siRNA) biogenesis
UniProt: P97473
Entrez ID: 21357
|
Does Knockout of Serhl in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Serhl
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Serhl (serine hydrolase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity; CC: cytoplasm, cytoplasmic vesicle, mitochondrion, perinuclear region of cytoplasm, peroxisome
Pathways:
UniProt: Q9EPB5
Entrez ID: 68607
|
Does Knockout of Icosl in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Icosl
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Icosl (icos ligand)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, T cell activation, T cell receptor signaling pathway, T follicular helper cell differentiation, adaptive immune response, immune system process, isotype switching, positive regulation of activated T cell proliferation, positive regulation of interleukin-4 production, regulation of cytokine production, signal transduction; MF: identical protein binding, protein binding, receptor ligand activity, signaling receptor binding; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: Adaptive Immune System, Cell adhesion molecules - Mus musculus (mouse), Co-stimulation by ICOS, Immune System, Intestinal immune network for IgA production - Mus musculus (mouse), Regulation of T cell activation by CD28 family
UniProt: Q9JHJ8
Entrez ID: 50723
|
Does Knockout of Gapt in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Gapt
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Gapt (Grb2-binding adaptor, transmembrane)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell homeostasis, B cell proliferation involved in immune response; CC: Golgi apparatus, membrane, plasma membrane
Pathways:
UniProt: Q8CB93
Entrez ID: 238875
|
Does Knockout of Cks1b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Cks1b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cks1b (CDC28 protein kinase 1b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, fibroblast proliferation, mitotic cell cycle phase transition, regulation of DNA-templated transcription, regulation of mitotic cell cycle; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, histone binding, protein kinase binding, ubiquitin binding; CC: SCF ubiquitin ligase complex, cyclin-dependent protein kinase holoenzyme complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , G1 Phase, G1/S Transition, Mitotic G1 phase and G1/S transition, Pathways in cancer - Mus musculus (mouse), S Phase, SCF(Skp2)-mediated degradation of p27/p21, Small cell lung cancer - Mus musculus (mouse)
UniProt: P61025
Entrez ID: 54124
|
Does Knockout of Thada in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Thada
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Thada (thyroid adenoma associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid homeostasis, negative regulation of endoplasmic reticulum calcium ion concentration, tRNA methylation, tRNA nucleoside ribose methylation, tRNA processing; MF: enzyme regulator activity, molecular_function
Pathways:
UniProt: A8C756
Entrez ID: 240174
|
Does Knockout of Sacm1l in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,276
|
Knockout
|
Sacm1l
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sacm1l (SAC1 suppressor of actin mutations 1-like (yeast))
Type: protein-coding
Summary: This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Dec 2017].
Gene Ontology: BP: exocytic insertion of neurotransmitter receptor to postsynaptic membrane, lipid metabolic process, neurotransmitter receptor transport to postsynaptic membrane, phosphatidylinositol dephosphorylation, vesicle-mediated transport in synapse; MF: hydrolase activity, phosphatase activity, phosphatidylinositol-3,5-bisphosphate phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity, phosphatidylinositol-4-phosphate phosphatase activity, protein binding; CC: AMPA glutamate receptor complex, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, glutamatergic synapse, membrane
Pathways: Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Synthesis of PIPs at the ER membrane, Synthesis of PIPs at the Golgi membrane
UniProt: Q9EP69
Entrez ID: 83493
|
Does Knockout of Rfx4 in cardiac muscle cell line causally result in protein/peptide accumulation?
| 0
| 1,662
|
Knockout
|
Rfx4
|
protein/peptide accumulation
|
cardiac muscle cell line
|
Gene: Rfx4 (regulatory factor X, 4 (influences HLA class II expression))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellar cortex morphogenesis, cilium assembly, dorsal spinal cord development, forebrain development, midbrain development, negative regulation of smoothened signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of protein processing, regulation of transcription by RNA polymerase II, spinal cord dorsal/ventral patterning, telencephalon development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, protein binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q7TNK1
Entrez ID: 71137
|
Does Knockout of Unc13a in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Unc13a
|
cell cycle progression
|
breast epithelium
|
Gene: Unc13a (unc-13 homolog A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SNARE complex assembly, amyloid-beta metabolic process, cell differentiation, chemical synaptic transmission, dense core granule docking, dense core granule priming, exocytosis, innervation, long-term synaptic potentiation, neuromuscular junction development, neuronal dense core vesicle exocytosis, neurotransmitter secretion, positive regulation of dendrite extension, positive regulation of glutamate receptor signaling pathway, positive regulation of neurotransmitter secretion, positive regulation of synaptic plasticity, positive regulation of vesicle fusion, regulation of amyloid precursor protein catabolic process, regulation of calcium-dependent activation of synaptic vesicle fusion, regulation of short-term neuronal synaptic plasticity, regulation of synaptic vesicle priming, synaptic transmission, glutamatergic, synaptic vesicle docking, synaptic vesicle exocytosis, synaptic vesicle maturation, synaptic vesicle priming; MF: SNARE binding, calcium ion binding, calmodulin binding, diacylglycerol binding, identical protein binding, metal ion binding, phospholipid binding, protein binding, protein domain specific binding, protein-containing complex binding, spectrin binding, syntaxin binding, syntaxin-1 binding, zinc ion binding; CC: Golgi-associated vesicle, axon, calyx of Held, cell projection, cytoplasm, excitatory synapse, glutamatergic synapse, membrane, neuromuscular junction, neuron projection, plasma membrane, presynapse, presynaptic active zone, presynaptic membrane, protein-containing complex, synapse, synaptic membrane, synaptic vesicle membrane, terminal bouton
Pathways: Synaptic vesicle cycle - Mus musculus (mouse)
UniProt: Q4KUS2
Entrez ID: 382018
|
Does Knockout of Tm9sf4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Tm9sf4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tm9sf4 (transmembrane 9 superfamily member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, phagocytosis, positive regulation of protein exit from endoplasmic reticulum, positive regulation of protein localization to cell surface, protein localization to membrane, regulation of intracellular pH, response to hypoxia, vacuolar proton-transporting V-type ATPase complex assembly; CC: Golgi apparatus, early endosome, endosome, membrane
Pathways:
UniProt: Q8BH24
Entrez ID: 99237
|
Does Knockout of Piezo1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Piezo1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Piezo1 (piezo-type mechanosensitive ion channel component 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to mechanical stimulus, detection of mechanical stimulus, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of cell-cell adhesion mediated by integrin, positive regulation of integrin activation, positive regulation of myotube differentiation, regulation of membrane potential; MF: identical protein binding, mechanosensitive monoatomic cation channel activity, mechanosensitive monoatomic ion channel activity, monoatomic cation channel activity, protein binding; CC: cell projection, cuticular plate, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, lamellipodium membrane, membrane, plasma membrane, stereocilium
Pathways:
UniProt: F7AC58, E9PUQ9, F6PYU5, F6QY99
Entrez ID: 234839
|
Does Knockout of Kcnip3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Kcnip3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Kcnip3 (Kv channel interacting protein 3, calsenilin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, behavioral response to pain, intracellular protein transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, potassium ion transmembrane transport, potassium ion transport, protein localization to plasma membrane, regulation of neuron apoptotic process, regulation of potassium ion transmembrane transport, regulation of signal transduction, response to magnesium ion, response to pain, sensory perception of pain; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, calcium ion binding, calcium-dependent protein binding, core promoter sequence-specific DNA binding, magnesium ion binding, metal ion binding, potassium channel activity, potassium channel regulator activity, protein binding, protein homodimerization activity, sequence-specific DNA binding, transmembrane transporter binding; CC: Golgi apparatus, axon, axon terminus, cytoplasm, cytosol, dendrite, endoplasmic reticulum, membrane, monoatomic ion channel complex, nucleus, plasma membrane, protein-DNA complex, voltage-gated potassium channel complex
Pathways: Cardiac conduction, Muscle contraction, Phase 1 - inactivation of fast Na+ channels
UniProt: Q9QXT8
Entrez ID: 56461
|
Does Knockout of Zfp449 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Zfp449
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp449 (zinc finger protein 449)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of transcription by RNA polymerase II, spermatogonial cell division; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: Q8CB76
Entrez ID: 78619
|
Does Knockout of Angpt4 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Angpt4
|
response to virus
|
Microglial Cell Line
|
Gene: Angpt4 (angiopoietin 4)
Type: protein-coding
Summary: This gene is a member of the angiopoietin family of secreted growth factors comprising Angiopoietins-1, -2, and -3, all of which bind the TEK Receptor Tyrosine Kinase. Angiopoietin/TEK Receptor Tyrosine Kinase signaling is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance of vascular integrity. Angiopoietin/TEK Receptor Tyrosine Kinase signaling is also required for lymphangiogenesis. Family members bind TEK Receptor Tyrosine Kinase as multimeric clusters but their oligomerization properties differ from one another and this is thought to provide a mechanistic basis for their distinct physiologic roles. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: Notch signaling pathway, Tie signaling pathway, angiogenesis, blood coagulation, cellular response to hypoxia, endoderm development, negative regulation of angiogenesis, negative regulation of apoptotic process, negative regulation of blood vessel endothelial cell migration, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of endothelial cell migration, signal transduction; MF: receptor tyrosine kinase binding, transmembrane receptor protein tyrosine kinase activator activity, vascular endothelial growth factor receptor binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Cell surface interactions at the vascular wall, HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, MAPK signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Tie2 Signaling
UniProt: Q9WVH6
Entrez ID: 11602
|
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