prompt
string
hit
int64
screen_id
int64
crispr_strategy
string
gene
string
phenotype
string
cell_type
string
gene_context
string
Does Knockout of Carf in Mouse cell causally result in protein/peptide accumulation?
0
1,047
Knockout
Carf
protein/peptide accumulation
Mouse cell
Gene: Carf (calcium response factor) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular response to calcium ion, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription a...
Does Knockout of Sds in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
1,565
Knockout
Sds
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Sds (serine dehydratase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: L-serine catabolic process, amino acid metabolic process, gluconeogenesis, lipid metabolic process, protein-containing complex assembly, pyruvate biosynthetic process, small molecule biosynthet...
Does Knockout of Dcpp3 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
0
1,077
Knockout
Dcpp3
protein/peptide accumulation
Mouse Embryonic Stem Cell
Gene: Dcpp3 (demilune cell and parotid protein 3) Type: protein-coding Summary: No summary available. Gene Ontology: MF: carbohydrate binding, molecular_function; CC: extracellular space Pathways: UniProt: L7N259 Entrez ID: 620253
Does Knockout of Pop1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
1
81
Knockout
Pop1
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Pop1 (processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: tRNA 5'-leader removal, tRNA decay, tRNA processing; MF: ribonuclease P RNA binding, ribonuclease P activity; CC: multimeric ribonuclease P c...
Does Knockout of Fancl in Melanoma Cell Line causally result in cell proliferation?
0
2,488
Knockout
Fancl
cell proliferation
Melanoma Cell Line
Gene: Fancl (Fanconi anemia, complementation group L) Type: protein-coding Summary: This gene encodes the complementation group L subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes. The FA complex is ne...
Does Knockout of Ldhb in Regulatory T cell causally result in cell proliferation?
0
1,483
Knockout
Ldhb
cell proliferation
Regulatory T cell
Gene: Ldhb (lactate dehydrogenase B) Type: protein-coding Summary: This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript...
Does Knockout of Huwe1 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,481
Knockout
Huwe1
protein/peptide accumulation
Regulatory T cell
Gene: Huwe1 (HECT, UBA and WWE domain containing 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, Golgi organization, base-excision repair, canonical NF-kappaB signal transduction, cell differentiation, chromatin remodeling, circadian re...
Does Knockout of Fam8a1 in myoblast cell line causally result in protein/peptide distribution?
0
1,683
Knockout
Fam8a1
protein/peptide distribution
myoblast cell line
Gene: Fam8a1 (family with sequence similarity 8, member A1) Type: protein-coding Summary: No summary available. Gene Ontology: CC: Hrd1p ubiquitin ligase complex, membrane Pathways: UniProt: Q3URQ4 Entrez ID: 97863
Does Knockout of Mup9 in myoblast cell line causally result in protein/peptide distribution?
0
1,679
Knockout
Mup9
protein/peptide distribution
myoblast cell line
Gene: Mup9 (major urinary protein 9) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: P02762 Entrez ID: 100038948
Does Knockout of Tmem63b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
Tmem63b
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Tmem63b (transmembrane protein 63b) Type: protein-coding Summary: No summary available. Gene Ontology: BP: drinking behavior, exocytosis, intermembrane lipid transfer, intestinal stem cell homeostasis, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, mono...
Does Knockout of Syt6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
161
Knockout
Syt6
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Syt6 (synaptotagmin VI) Type: protein-coding Summary: No summary available. Gene Ontology: BP: acrosomal vesicle exocytosis, acrosome reaction, chemical synaptic transmission, postsynaptic dense core vesicle exocytosis, regulation of calcium ion-dependent exocytosis, vesicle-mediated tran...
Does Knockout of Palm in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,286
Knockout
Palm
cell proliferation
Mouse kidney carcinoma cell
Gene: Palm (paralemmin) Type: protein-coding Summary: Enables D3 dopamine receptor binding activity. Involved in several processes, including cellular response to electrical stimulus; positive regulation of dendritic spine development; and positive regulation of filopodium assembly. Acts upstream of or ...
Does Knockout of Cox11 in Regulatory T cell causally result in cell proliferation?
0
1,483
Knockout
Cox11
cell proliferation
Regulatory T cell
Gene: Cox11 (cytochrome c oxidase assembly protein 11, copper chaperone) Type: protein-coding Summary: Predicted to enable copper ion binding activity. Acts upstream of or within negative regulation of glucokinase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochond...
Does Knockout of Ccdc85b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,266
Knockout
Ccdc85b
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Ccdc85b (coiled-coil domain containing 85B) Type: protein-coding Summary: Predicted to enable delta-catenin binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of fat cell differentiation. Located in nucleus. Orthologous to human CCDC85B (coiled...
Does Knockout of Dennd2a in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,287
Knockout
Dennd2a
cell proliferation
Mouse kidney carcinoma cell
Gene: Dennd2a (DENN domain containing 2A) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein transport, retrograde transport, endosome to Golgi; MF: guanyl-nucleotide exchange factor activity; CC: actin cytoskeleton, cytoplasm, cytoskeleton, cytosol Pathways...
Does Knockout of Cyth1 in myoblast cell line causally result in protein/peptide distribution?
0
1,682
Knockout
Cyth1
protein/peptide distribution
myoblast cell line
Gene: Cyth1 (cytohesin 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: establishment of epithelial cell polarity, presynaptic modulation of chemical synaptic transmission, regulation of ARF protein signal transduction; MF: guanyl-nucleotide exchange factor activity, li...
Does Knockout of Klra3 in breast epithelium causally result in cell cycle progression?
0
1,469
Knockout
Klra3
cell cycle progression
breast epithelium
Gene: Klra3 (killer cell lectin-like receptor, subfamily A, member 3) Type: protein-coding Summary: No summary available. Gene Ontology: MF: carbohydrate binding, signaling receptor activity; CC: cell surface, membrane, plasma membrane Pathways: Natural killer cell mediated cytotoxicit...
Does Knockout of Prm1 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,276
Knockout
Prm1
cell proliferation
Colonic Cancer Cell Line
Gene: Prm1 (protamine 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, chromosome condensation, nucleus organization, sperm DNA condensation, spermatid development, spermatogenesis; MF: DNA binding; CC: chromosome, cytosol, male germ cell nucleus, ...
Does Knockout of Sh3kbp1 in Embryonic Stem Cell Line causally result in cell proliferation?
0
579
Knockout
Sh3kbp1
cell proliferation
Embryonic Stem Cell Line
Gene: Sh3kbp1 (SH3-domain kinase binding protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: actin filament organization, apoptotic process, cell migration, cytoskeleton organization, endocytosis, positive regulation of B cell activation, regulation of cell shape, ...
Does Knockout of Il7r in Colonic Cancer Cell Line causally result in tumorigenicity?
0
2,177
Knockout
Il7r
tumorigenicity
Colonic Cancer Cell Line
Gene: Il7r (interleukin 7 receptor) Type: protein-coding Summary: Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) ...
Does Knockout of Ifngr2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,266
Knockout
Ifngr2
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Ifngr2 (interferon gamma receptor 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cytokine-mediated signaling pathway, defense response to virus, microglial cell activation, positive regulation of glutamate receptor signaling pathway, type II interferon-mediated ...
Does Knockout of 4731417B20Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
1,130
Knockout
4731417B20Rik
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: 4731417B20Rik (RIKEN cDNA 4731417B20 gene) Type: unknown Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID: 74576
Does Knockout of Trmt11 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,399
Knockout
Trmt11
protein/peptide accumulation
Microglial Cell Line
Gene: Trmt11 (tRNA methyltransferase 11) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA processing, methylation, tRNA processing; MF: RNA binding, methyltransferase activity, nucleic acid binding, tRNA (guanine(10)-N2)-methyltransferase activity, tRNA binding, transf...
Does Knockout of Defb8 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,399
Knockout
Defb8
protein/peptide accumulation
Microglial Cell Line
Gene: Defb8 (defensin beta 8) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell chemotaxis, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, innate immune response, positive chemo...
Does Knockout of Aqp3 in macrophage causally result in phagocytosis?
0
1,890
Knockout
Aqp3
phagocytosis
macrophage
Gene: Aqp3 (aquaporin 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cellular response to hypoxia, establishment of localization in cell, glycerol transmembrane transport, odontogenesis, polyol transmembrane transport, positive regulation of immune system process, ren...
Does Knockout of Aldh3b3 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,263
Knockout
Aldh3b3
cell proliferation
Colonic Cancer Cell Line
Gene: Aldh3b3 (aldehyde dehydrogenase 3 family, member B3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: aldehyde metabolic process; MF: 3-chloroallyl aldehyde dehydrogenase activity, aldehyde dehydrogenase (NAD+) activity, aldehyde dehydrogenase [NAD(P)+] activity, oxi...
Does Knockout of Ttpal in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,276
Knockout
Ttpal
cell proliferation
Colonic Cancer Cell Line
Gene: Ttpal (tocopherol (alpha) transfer protein-like) Type: protein-coding Summary: No summary available. Gene Ontology: MF: molecular_function, phosphatidylinositol bisphosphate binding Pathways: UniProt: Q9D3D0 Entrez ID: 76080
Does Knockout of Rpp21 in myoblast cell line causally result in protein/peptide distribution?
0
1,683
Knockout
Rpp21
protein/peptide distribution
myoblast cell line
Gene: Rpp21 (ribonuclease P 21 subunit) Type: protein-coding Summary: No summary available. Gene Ontology: BP: RNA processing, response to xenobiotic stimulus, tRNA 5'-leader removal, tRNA processing; MF: metal ion binding, ribonuclease P RNA binding, ribonuclease P activity; CC: endoribonuclea...
Does Knockout of Cyb5r3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,262
Knockout
Cyb5r3
cell proliferation
Breast Adenocarcinoma Cell Line
Gene: Cyb5r3 (cytochrome b5 reductase 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cholesterol biosynthetic process, cholesterol metabolic process, lipid metabolic process, nitric oxide biosynthetic process, steroid biosynthetic process, steroid metabolic process, s...
Does Knockout of Rpain in Lymphoma Cell Line causally result in response to chemicals?
0
1,547
Knockout
Rpain
response to chemicals
Lymphoma Cell Line
Gene: Rpain (RPA interacting protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA recombination, DNA repair, DNA-templated DNA replication, protein import into nucleus, response to UV; MF: metal ion binding, protein-containing complex binding, zinc ion binding; CC...
Does Knockout of Tcf7l2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,279
Knockout
Tcf7l2
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Tcf7l2 (transcription factor 7 like 2, T cell specific, HMG box) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Wnt signaling pathway, blood vessel development, bone mineralization, canonical Wnt signaling pathway, cell differentiation, cellular response to starvat...
Does Knockout of Upf2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
Upf2
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: Upf2 (UPF2 regulator of nonsense transcripts homolog (yeast)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: animal organ regeneration, liver development, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, response to unfolded protein; MF: RNA bin...
Does Knockout of Nhlh2 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Nhlh2
protein/peptide accumulation
Embryonic Cell Line
Gene: Nhlh2 (nescient helix loop helix 2) Type: protein-coding Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor bindin...
Does Knockout of Ube2e3 in Regulatory T cell causally result in protein/peptide accumulation?
1
1,481
Knockout
Ube2e3
protein/peptide accumulation
Regulatory T cell
Gene: Ube2e3 (ubiquitin-conjugating enzyme E2E 3) Type: protein-coding Summary: Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein K11-linked ubiquitination; protein K48-linked ubiquitination; and protein K63-linked ubiquitination. Located in nucleus. Orthologous to human...
Does Knockout of Zswim5 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Zswim5
phagocytosis
macrophage
Gene: Zswim5 (zinc finger SWIM-type containing 5) Type: protein-coding Summary: No summary available. Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding Pathways: UniProt: Q80TC6 Entrez ID: 74464
Does Knockout of Wdr25 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,272
Knockout
Wdr25
cell proliferation
Mouse kidney carcinoma cell
Gene: Wdr25 (WD repeat domain 25) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: UniProt: E9Q349 Entrez ID: 212198
Does Knockout of Ecm1 in Colonic Cancer Cell Line causally result in tumorigenicity?
0
2,178
Knockout
Ecm1
tumorigenicity
Colonic Cancer Cell Line
Gene: Ecm1 (extracellular matrix protein 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: angiogenesis, biomineral tissue development, chondrocyte development, endochondral bone growth, inflammatory response, negative regulation of bone mineralization, negative regulati...
Does Knockout of Tsen15 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Tsen15
protein/peptide accumulation
Embryonic Cell Line
Gene: Tsen15 (tRNA splicing endonuclease subunit 15) Type: protein-coding Summary: Predicted to enable nucleic acid binding activity. Predicted to be involved in mRNA processing and tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be located in nucleolus. Human ortholog(s) of this ...
Does Knockout of Gpbar1 in Colonic Cancer Cell Line causally result in cell proliferation?
0
1,264
Knockout
Gpbar1
cell proliferation
Colonic Cancer Cell Line
Gene: Gpbar1 (G protein-coupled bile acid receptor 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway, cellular response to bile acid, energy ...
Does Knockout of Naga in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,268
Knockout
Naga
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Naga (N-acetyl galactosaminidase, alpha) Type: protein-coding Summary: No summary available. Gene Ontology: BP: carbohydrate catabolic process, carbohydrate metabolic process, glycolipid catabolic process, glycoside catabolic process, lipid metabolic process, oligosaccharide metabolic pro...
Does Knockout of Aldh18a1 in Regulatory T cell causally result in cell proliferation?
0
1,483
Knockout
Aldh18a1
cell proliferation
Regulatory T cell
Gene: Aldh18a1 (aldehyde dehydrogenase 18 family, member A1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: L-proline biosynthetic process, amino acid biosynthetic process, citrulline biosynthetic process, glutamate metabolic process, ornithine biosynthetic process, resp...
Does Knockout of Pigh in Colonic Cancer Cell Line causally result in cell proliferation?
1
1,275
Knockout
Pigh
cell proliferation
Colonic Cancer Cell Line
Gene: Pigh (phosphatidylinositol glycan anchor biosynthesis, class H) Type: protein-coding Summary: No summary available. Gene Ontology: BP: GPI anchor biosynthetic process; CC: cytoplasm, endoplasmic reticulum membrane, glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) com...
Does Knockout of Slc26a11 in Microglial Cell Line causally result in response to virus?
0
2,429
Knockout
Slc26a11
response to virus
Microglial Cell Line
Gene: Slc26a11 (solute carrier family 26, member 11) Type: protein-coding Summary: No summary available. Gene Ontology: BP: chloride transmembrane transport, monoatomic ion transport, oxalate transport, sulfate transmembrane transport, transmembrane transport; MF: antiporter activity, chloride ...
Does Knockout of Zcchc4 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,481
Knockout
Zcchc4
protein/peptide accumulation
Regulatory T cell
Gene: Zcchc4 (zinc finger, CCHC domain containing 4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: methylation, positive regulation of translation, rRNA methylation; MF: S-adenosyl-L-methionine binding, metal ion binding, methyltransferase activity, nucleic acid binding...
Does Knockout of Kpna7 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,287
Knockout
Kpna7
cell proliferation
Mouse kidney carcinoma cell
Gene: Kpna7 (karyopherin subunit alpha 7) Type: protein-coding Summary: No summary available. Gene Ontology: BP: NLS-bearing protein import into nucleus, blastocyst development, epigenetic regulation of gene expression, negative regulation of gene expression, positive regulation of gene express...
Does Knockout of Npr1 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,398
Knockout
Npr1
protein/peptide accumulation
Microglial Cell Line
Gene: Npr1 (natriuretic peptide receptor 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: blood vessel diameter maintenance, cGMP biosynthetic process, cGMP-mediated signaling, cell surface receptor signaling pathway, cyclic nucleotide biosynthetic process, dopamine met...
Does Knockout of Pde9a in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,289
Knockout
Pde9a
cell proliferation
Mouse kidney carcinoma cell
Gene: Pde9a (phosphodiesterase 9A) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cGMP catabolic process, cGMP metabolic process, negative regulation of cAMP/PKA signal transduction, negative regulation of neural precursor cell proliferation, positive regulation of cardi...
Does Knockout of Mmgt2 in myoblast cell line causally result in protein/peptide distribution?
0
1,683
Knockout
Mmgt2
protein/peptide distribution
myoblast cell line
Gene: Mmgt2 (membrane magnesium transporter 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cobalt ion transport, copper ion transmembrane transport, copper ion transport, magnesium ion transmembrane transport, magnesium ion transport, manganese ion transmembrane trans...
Does Knockout of Mir21c in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Mir21c
cell cycle progression
breast epithelium
Gene: Mir21c (microRNA 21c) Type: ncRNA Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I...
Does Knockout of Zfp65 in Regulatory T cell causally result in cell proliferation?
0
1,484
Knockout
Zfp65
cell proliferation
Regulatory T cell
Gene: Zfp65 (zinc finger protein 65) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA po...
Does Knockout of Arhgap29 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,280
Knockout
Arhgap29
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Arhgap29 (Rho GTPase activating protein 29) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of small GTPase mediated signal transduction, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity,...
Does Knockout of Ndufa11 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Ndufa11
protein/peptide accumulation
Embryonic Cell Line
Gene: Ndufa11 (NADH:ubiquinone oxidoreductase subunit A11) Type: protein-coding Summary: No summary available. Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner ...
Does Knockout of Eif5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
688
Knockout
Eif5
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Eif5 (eukaryotic translation initiation factor 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: formation of cytoplasmic translation initiation complex, regulation of translational initiation, ribosome assembly, translation, translational initiation; MF: GDP-disso...
Does Knockout of Paxip1 in Lymphoma Cell Line causally result in response to chemicals?
0
1,537
Knockout
Paxip1
response to chemicals
Lymphoma Cell Line
Gene: Paxip1 (PAX interacting (with transcription-activation domain) protein 1) Type: protein-coding Summary: This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-st...
Does Knockout of Clcn2 in Melanoma Cell Line causally result in cell proliferation?
0
1,269
Knockout
Clcn2
cell proliferation
Melanoma Cell Line
Gene: Clcn2 (chloride channel, voltage-sensitive 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: acinar cell differentiation, cell differentiation involved in salivary gland development, cellular hypotonic response, chloride transmembrane transport, chloride transport,...
Does Knockout of Nln in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,267
Knockout
Nln
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Nln (neurolysin (metallopeptidase M3 family)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: peptide catabolic process, peptide metabolic process, protein catabolic process, proteolysis, regulation of gluconeogenesis, regulation of skeletal muscle fiber differentia...
Does Knockout of Rps6ka5 in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
Rps6ka5
cell viability
Immortal mouse chromaffin cells
Gene: Rps6ka5 (ribosomal protein S6 kinase, polypeptide 5) Type: protein-coding Summary: No summary available. Gene Ontology: BP: TORC1 signaling, chromatin remodeling, inflammatory response, interleukin-1-mediated signaling pathway, intracellular signal transduction, negative regulation of DNA...
Does Knockout of Prx in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
0
1,077
Knockout
Prx
protein/peptide accumulation
Mouse Embryonic Stem Cell
Gene: Prx (periaxin) Type: protein-coding Summary: No summary available. Gene Ontology: BP: peripheral nervous system myelin formation, peripheral nervous system myelin maintenance, regulation of RNA splicing, sensory perception of pain, transmission of nerve impulse; CC: anchoring junction, cy...
Does Knockout of Dnmbp in Mouse cell causally result in protein/peptide accumulation?
0
1,047
Knockout
Dnmbp
protein/peptide accumulation
Mouse cell
Gene: Dnmbp (dynamin binding protein) Type: protein-coding Summary: This gene encodes a member of the DBL family of guanine nucleotide exchange factors. The encoded protein has been proposed to regulate the actin cytoskeleton by specifically activating the Rho-family GTPase Cdc42. An interaction between...
Does Knockout of Trpc3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,267
Knockout
Trpc3
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Trpc3 (transient receptor potential cation channel, subfamily C, member 3) Type: protein-coding Summary: No summary available. Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulati...
Does Knockout of Gm10797 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
0
1,274
Knockout
Gm10797
cell proliferation
Mammary Gland Tumor Cell Line
Gene: Gm10797 (predicted gene 10797) Type: Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID:
Does Knockout of Zbtb6 in myoblast cell line causally result in protein/peptide distribution?
0
1,681
Knockout
Zbtb6
protein/peptide distribution
myoblast cell line
Gene: Zbtb6 (zinc finger and BTB domain containing 6) Type: protein-coding Summary: No summary available. Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcript...
Does Knockout of 4933402N03Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,283
Knockout
4933402N03Rik
cell proliferation
Mouse kidney carcinoma cell
Gene: 4933402N03Rik (RIKEN cDNA 4933402N03 gene) Type: protein-coding Summary: Orthologous to human C10orf120 (chromosome 10 open reading frame 120). [provided by Alliance of Genome Resources, Jul 2025] Gene Ontology: Pathways: UniProt: Q8CDT9 Entrez ID: 233918
Does Knockout of Morn3 in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Morn3
cell cycle progression
breast epithelium
Gene: Morn3 (MORN repeat containing 3) Type: protein-coding Summary: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in negative regulation of signal transduction by p53 class mediator. Predicted to be located in acrosomal vesicle. Is expressed in lung. Orthologous t...
Does Knockout of Sfxn3 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
0
2,474
Knockout
Sfxn3
protein/peptide accumulation
Embryonic Fibroblast Cell Line
Gene: Sfxn3 (sideroflexin 3) Type: protein-coding Summary: Predicted to enable L-serine transmembrane transporter activity. Predicted to be involved in serine import into mitochondrion. Located in mitochondrion. Orthologous to human SFXN3 (sideroflexin 3). [provided by Alliance of Genome Resources, Jul ...
Does Knockout of Fuca2 in Melanoma Cell Line causally result in cell proliferation?
0
1,270
Knockout
Fuca2
cell proliferation
Melanoma Cell Line
Gene: Fuca2 (fucosidase, alpha-L- 2, plasma) Type: protein-coding Summary: No summary available. Gene Ontology: BP: carbohydrate metabolic process, fucose metabolic process, glycoside catabolic process, regulation of entry of bacterium into host cell, response to bacterium; MF: alpha-L-fucosida...
Does Knockout of Tnrc18 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Tnrc18
phagocytosis
macrophage
Gene: Tnrc18 (trinucleotide repeat containing 18) Type: protein-coding Summary: No summary available. Gene Ontology: BP: protein localization to chromatin, transposable element silencing by heterochromatin formation; MF: chromatin binding, chromatin-protein adaptor activity, histone H3K9me2/3 r...
Does Knockout of P4htm in Melanoma Cell Line causally result in cell proliferation?
0
2,493
Knockout
P4htm
cell proliferation
Melanoma Cell Line
Gene: P4htm (prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of erythrocyte differentiation; MF: 2-oxoglutarate-dependent dioxygenase activity, L-ascorbic acid binding, calcium ion binding, dioxygenas...
Does Knockout of Spout1 in breast epithelium causally result in cell cycle progression?
0
1,468
Knockout
Spout1
cell cycle progression
breast epithelium
Gene: Spout1 (SPOUT domain containing methyltransferase 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell division, maintenance of centrosome location, methylation, miRNA processing, post-transcriptional regulation of gene expression, rRNA base methylation, rRNA pro...
Does Knockout of Zfp959 in Melanoma Cell Line causally result in cell proliferation?
0
1,269
Knockout
Zfp959
cell proliferation
Melanoma Cell Line
Gene: Zfp959 (zinc finger protein 959) Type: protein-coding Summary: No summary available. Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, meta...
Does Knockout of Prdm4 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,260
Knockout
Prdm4
cell proliferation
Mouse kidney carcinoma cell
Gene: Prdm4 (PR domain containing 4) Type: protein-coding Summary: This gene encodes a member of the PR/SET family of zinc finger proteins. This protein has been shown to bind DNA in a sequence-specific manner and has been implicated in neural stem cell proliferation and differentiation. Pseudogenes hav...
Does Knockout of Trim29 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
84
Knockout
Trim29
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: Trim29 (tripartite motif-containing 29) Type: protein-coding Summary: No summary available. Gene Ontology: BP: immune system process, innate immune response, negative regulation of protein localization to nucleus, negative regulation of transcription by RNA polymerase II; MF: identical pr...
Does Knockout of Miga2 in Melanoma Cell Line causally result in cell proliferation?
0
1,281
Knockout
Miga2
cell proliferation
Melanoma Cell Line
Gene: Miga2 (mitoguardin 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: bone development, mitochondrial fusion; MF: protein heterodimerization activity, protein homodimerization activity; CC: membrane, mitochondrial outer membrane, mitochondrion, plasma membrane ...
Does Knockout of Dynlt1a in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Dynlt1a
protein/peptide accumulation
Embryonic Cell Line
Gene: Dynlt1a (dynein light chain Tctex-type 1A) Type: protein-coding Summary: No summary available. Gene Ontology: Pathways: Immune System, Innate Immune System, Neutrophil degranulation, Salmonella infection - Mus musculus (mouse) UniProt: P51807 Entrez ID: 10031087...
Does Knockout of Msx1 in myoblast cell line causally result in protein/peptide distribution?
1
1,685
Knockout
Msx1
protein/peptide distribution
myoblast cell line
Gene: Msx1 (msh homeobox 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: BMP signaling pathway, activation of meiosis, anterior/posterior pattern specification, bone morphogenesis, cartilage development, cartilage morphogenesis, cell morphogenesis, cell surface recepto...
Does Knockout of Vps51 in Microglial Cell Line causally result in protein/peptide accumulation?
0
1,398
Knockout
Vps51
protein/peptide accumulation
Microglial Cell Line
Gene: Vps51 (VPS51 GARP complex subunit) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Golgi organization, Golgi vesicle transport, autophagy, brain morphogenesis, endocytic recycling, lipid transport, lysosomal transport, protein targeting, protein transport, retrograd...
Does Knockout of Ndufs4 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
2,175
Knockout
Ndufs4
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Ndufs4 (NADH:ubiquinone oxidoreductase core subunit S4) Type: protein-coding Summary: No summary available. Gene Ontology: BP: adult behavior, adult walking behavior, aerobic respiration, brain development, cellular response to oxygen levels, cognition, dopamine metabolic process, electro...
Does Knockout of Fcho1 in macrophage causally result in phagocytosis?
0
1,889
Knockout
Fcho1
phagocytosis
macrophage
Gene: Fcho1 (FCH domain only 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: T cell receptor signaling pathway, clathrin coat assembly, clathrin-dependent endocytosis, endocytosis, positive regulation of T cell activation; MF: AP-2 adaptor complex binding, protein bind...
Does Knockout of H2al1k in Immortal mouse chromaffin cells causally result in cell viability?
0
2,469
Knockout
H2al1k
cell viability
Immortal mouse chromaffin cells
Gene: H2al1k (H2A histone family member L1K) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell differentiation, chromosome organization, heterochromatin formation, spermatogenesis; MF: DNA binding, protein heterodimerization activity, structural constituent of chromati...
Does Knockout of Tnks2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
0
687
Knockout
Tnks2
tumorigenicity
Immortal Mouse Liver-derived Cell Line
Gene: Tnks2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2) Type: protein-coding Summary: Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Acts upstream of or within regulation of growth. ...
Does Knockout of Ndst1 in Immortal mouse chromaffin cells causally result in cell viability?
1
2,469
Knockout
Ndst1
cell viability
Immortal mouse chromaffin cells
Gene: Ndst1 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: animal organ morphogenesis, aorta development, cardiac septum development, cell population proliferation, coronary vasculature development, embryonic ne...
Does Knockout of Cdh7 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,152
Knockout
Cdh7
protein/peptide accumulation
Embryonic Cell Line
Gene: Cdh7 (cadherin 7, type 2) Type: protein-coding Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature pro...
Does Knockout of Ddx24 in Regulatory T cell causally result in cell proliferation?
0
2,127
Knockout
Ddx24
cell proliferation
Regulatory T cell
Gene: Ddx24 (DEAD box helicase 24) Type: protein-coding Summary: No summary available. Gene Ontology: MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: cytoplasm, nucleolus, nucleus ...
Does Knockout of Gm6455 in macrophage causally result in phagocytosis?
0
1,888
Knockout
Gm6455
phagocytosis
macrophage
Gene: Gm6455 (predicted gene 6455) Type: pseudo Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID: 623849
Does Knockout of Pla2g2c in breast epithelium causally result in cell cycle progression?
0
1,470
Knockout
Pla2g2c
cell cycle progression
breast epithelium
Gene: Pla2g2c (phospholipase A2, group IIC) Type: protein-coding Summary: No summary available. Gene Ontology: BP: arachidonate secretion, lipid catabolic process, lipid metabolic process, phosphatidylcholine metabolic process, phosphatidylglycerol metabolic process, phospholipid catabolic proc...
Does Knockout of Ehmt2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
0
2,308
Knockout
Ehmt2
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: Ehmt2 (euchromatic histone lysine N-methyltransferase 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, behavioral response to cocaine, cellular response to cocaine, cellular response to starvation, ...
Does Knockout of Myo5b in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,283
Knockout
Myo5b
cell proliferation
Mouse kidney carcinoma cell
Gene: Myo5b (myosin VB) Type: protein-coding Summary: No summary available. Gene Ontology: BP: actin filament organization, dendritic spine morphogenesis, endocytosis, endosomal transport, modulation of chemical synaptic transmission, neurotransmitter receptor transport, endosome to plasma memb...
Does Knockout of Sfr1 in Microglial Cell Line causally result in response to virus?
0
1,438
Knockout
Sfr1
response to virus
Microglial Cell Line
Gene: Sfr1 (SWI5 dependent recombination repair 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: DNA damage response, DNA repair, cellular response to estrogen stimulus, double-strand break repair via homologous recombination, positive regulation of DNA-templated transc...
Does Knockout of Aagab in Neuroblastoma Cell Line causally result in response to virus?
1
1,422
Knockout
Aagab
response to virus
Neuroblastoma Cell Line
Gene: Aagab (alpha- and gamma-adaptin binding protein) Type: protein-coding Summary: No summary available. Gene Ontology: BP: biological_process, protein transport; CC: cytoplasm, cytosol, nuclear speck Pathways: UniProt: Q8R2R3 Entrez ID: 66939
Does Knockout of Ccnk in Embryonic Stem Cell Line causally result in cell proliferation?
1
579
Knockout
Ccnk
cell proliferation
Embryonic Stem Cell Line
Gene: Ccnk (cyclin K) Type: protein-coding Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Acts upstream of or within in utero embryonic development and negative regulation of...
Does Knockout of Psmc3 in Regulatory T cell causally result in cell proliferation?
0
2,127
Knockout
Psmc3
cell proliferation
Regulatory T cell
Gene: Psmc3 (proteasome (prosome, macropain) 26S subunit, ATPase 3) Type: protein-coding Summary: Predicted to enable identical protein binding activity and proteasome-activating activity. Acts upstream of or within blastocyst development. Located in P-body. Part of proteasome accessory complex. Is expr...
Does Knockout of Ngef in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
0
1,664
Knockout
Ngef
tumorigenicity
Breast Adenocarcinoma Cell Line
Gene: Ngef (neuronal guanine nucleotide exchange factor) Type: protein-coding Summary: Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway; negative regulation of dendritic spine morphogenesis; and regulation of synapse pruning. Is active in glutamatergic synapse. Is ...
Does Knockout of 1810009J06Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
0
83
Knockout
1810009J06Rik
cell proliferation
Pre-B-Lymphocyte Cell Line
Gene: 1810009J06Rik (RIKEN cDNA 1810009J06 gene) Type: protein-coding Summary: No summary available. Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity Pathways: Influenza A - Mus musculus (mous...
Does Knockout of Fer in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,440
Knockout
Fer
protein/peptide accumulation
Embryonic Cell Line
Gene: Fer (FER tyrosine kinase) Type: protein-coding Summary: No summary available. Gene Ontology: BP: Fc-epsilon receptor signaling pathway, Kit signaling pathway, Sertoli cell development, actin cytoskeleton organization, adherens junction assembly, adherens junction disassembly, cell adhesio...
Does Knockout of Nol10 in Embryonic Cell Line causally result in protein/peptide accumulation?
0
1,152
Knockout
Nol10
protein/peptide accumulation
Embryonic Cell Line
Gene: Nol10 (nucleolar protein 10) Type: protein-coding Summary: No summary available. Gene Ontology: CC: nucleolus, nucleus, small-subunit processome Pathways: UniProt: Q5RJG1 Entrez ID: 217431
Does Knockout of F8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
0
165
Knockout
F8
regulation of signal transduction phenotype
Embryonic Fibroblast Cell Line
Gene: F8 (coagulation factor VIII) Type: protein-coding Summary: No summary available. Gene Ontology: BP: acute-phase response, blood coagulation, blood coagulation, intrinsic pathway, hemostasis; MF: copper ion binding, metal ion binding, oxidoreductase activity; CC: extracellular region, extr...
Does Knockout of Rrs1 in myoblast cell line causally result in protein/peptide distribution?
0
1,685
Knockout
Rrs1
protein/peptide distribution
myoblast cell line
Gene: Rrs1 (ribosome biogenesis regulator 1) Type: protein-coding Summary: No summary available. Gene Ontology: BP: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), hematopoietic progenitor cell ...
Does Knockout of Gucy1b2 in Regulatory T cell causally result in protein/peptide accumulation?
0
1,482
Knockout
Gucy1b2
protein/peptide accumulation
Regulatory T cell
Gene: Gucy1b2 (guanylate cyclase 1, soluble, beta 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cGMP biosynthetic process, cGMP-mediated signaling, cyclic nucleotide biosynthetic process, intracellular signal transduction, response to oxygen levels; MF: GTP binding, ...
Does Knockout of Pcdhb9 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,268
Knockout
Pcdhb9
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: Pcdhb9 (protocadherin beta 9) Type: protein-coding Summary: No summary available. Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane Pathways: ...
Does Knockout of Pank2 in Mouse kidney carcinoma cell causally result in cell proliferation?
0
1,286
Knockout
Pank2
cell proliferation
Mouse kidney carcinoma cell
Gene: Pank2 (pantothenate kinase 2) Type: protein-coding Summary: No summary available. Gene Ontology: BP: aerobic respiration, angiogenesis, coenzyme A biosynthetic process, mitochondrion organization, regulation of bile acid metabolic process, regulation of fatty acid metabolic process, regul...