prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Carf in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Carf
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Carf (calcium response factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to calcium ion, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: granular component, nucleus
Pathways:
UniProt: Q8VHI4
Entrez ID: 241066
|
Does Knockout of Sds in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Sds
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Sds (serine dehydratase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-serine catabolic process, amino acid metabolic process, gluconeogenesis, lipid metabolic process, protein-containing complex assembly, pyruvate biosynthetic process, small molecule biosynthetic process; MF: L-serine ammonia-lyase activity, lyase activity, protein homodimerization activity, pyridoxal phosphate binding, threonine deaminase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Glycine, serine and threonine metabolism - Mus musculus (mouse), L-serine degradation, Metabolism, Metabolism of amino acids and derivatives, Serine metabolism, Threonine catabolism, Valine, leucine and isoleucine biosynthesis - Mus musculus (mouse), glycine betaine degradation
UniProt: Q8VBT2
Entrez ID: 231691
|
Does Knockout of Dcpp3 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Dcpp3
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Dcpp3 (demilune cell and parotid protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, molecular_function; CC: extracellular space
Pathways:
UniProt: L7N259
Entrez ID: 620253
|
Does Knockout of Pop1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Pop1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pop1 (processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA 5'-leader removal, tRNA decay, tRNA processing; MF: ribonuclease P RNA binding, ribonuclease P activity; CC: multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonuclease MRP complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9D4G5, Q8K205
Entrez ID: 67724
|
Does Knockout of Fancl in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Fancl
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fancl (Fanconi anemia, complementation group L)
Type: protein-coding
Summary: This gene encodes the complementation group L subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes. The FA complex is necessary for protection against DNA damage. This gene product, an E3 ubiquitin ligase, catalyzes and is required for the monoubiquitination of the protein encoded by the Fanconi anemia, complementation group D2 gene, a critical step in the FA pathway (PMID: 12973351, 21229326). In mouse, mutations of this E3 ubiquitin ligase gene can lead to infertility in adult males and females, and a deletion of this gene can cause embryonic lethality in some genetic backgrounds. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: DNA damage response, DNA repair, gamete generation, interstrand cross-link repair, protein monoubiquitination, protein ubiquitination, regulation of cell population proliferation; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: Fanconi anaemia nuclear complex, chromatin, cytoplasm, nuclear body, nuclear envelope, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9CR14
Entrez ID: 67030
|
Does Knockout of Ldhb in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Ldhb
|
cell proliferation
|
Regulatory T cell
|
Gene: Ldhb (lactate dehydrogenase B)
Type: protein-coding
Summary: This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes 1 and 19. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: NAD+ metabolic process, carboxylic acid metabolic process, lactate biosynthetic process from pyruvate, lactate metabolic process, pyruvate catabolic process; MF: L-lactate dehydrogenase (NAD+) activity, NAD binding, catalytic activity, identical protein binding, kinase binding, lactate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: cytoplasm, cytosol, membrane, membrane raft, mitochondrial inner membrane, mitochondrion, myelin sheath, oxidoreductase complex
Pathways: Aerobic respiration and respiratory electron transport, Central carbon metabolism in cancer - Mus musculus (mouse), Cysteine and methionine metabolism - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, Propanoate metabolism - Mus musculus (mouse), Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), pyruvate fermentation to lactate
UniProt: P16125
Entrez ID: 16832
|
Does Knockout of Huwe1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Huwe1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Huwe1 (HECT, UBA and WWE domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, Golgi organization, base-excision repair, canonical NF-kappaB signal transduction, cell differentiation, chromatin remodeling, circadian regulation of gene expression, defense response to bacterium, membrane fusion, negative regulation of canonical NF-kappaB signal transduction, negative regulation of mitochondrial fusion, negative regulation of peroxisome proliferator activated receptor signaling pathway, peroxisome proliferator activated receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein ubiquitination, positive regulation of type 2 mitophagy, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein branched polyubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, rhythmic process, ubiquitin-dependent protein catabolic process; MF: DNA binding, histone ubiquitin ligase activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: Golgi membrane, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Innate Immune System, Neutrophil degranulation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q7TMY8
Entrez ID: 59026
|
Does Knockout of Fam8a1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Fam8a1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fam8a1 (family with sequence similarity 8, member A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Hrd1p ubiquitin ligase complex, membrane
Pathways:
UniProt: Q3URQ4
Entrez ID: 97863
|
Does Knockout of Mup9 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Mup9
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mup9 (major urinary protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: P02762
Entrez ID: 100038948
|
Does Knockout of Tmem63b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Tmem63b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tmem63b (transmembrane protein 63b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: drinking behavior, exocytosis, intermembrane lipid transfer, intestinal stem cell homeostasis, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, phospholipid transport, plasma membrane phospholipid scrambling, sensory perception of sound, surfactant secretion; MF: calcium-activated cation channel activity, mechanosensitive monoatomic cation channel activity, mechanosensitive monoatomic ion channel activity, osmolarity-sensing monoatomic cation channel activity, phosphatidylcholine transfer activity, phospholipid scramblase activity, protein binding, sphingomyelin transfer activity; CC: actin cytoskeleton, alveolar lamellar body membrane, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways:
UniProt: Q3TWI9
Entrez ID: 224807
|
Does Knockout of Syt6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Syt6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Syt6 (synaptotagmin VI)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acrosomal vesicle exocytosis, acrosome reaction, chemical synaptic transmission, postsynaptic dense core vesicle exocytosis, regulation of calcium ion-dependent exocytosis, vesicle-mediated transport; MF: SNARE binding, calcium ion sensor activity, calcium-dependent phospholipid binding, calcium-dependent protein binding, clathrin binding, identical protein binding, metal ion binding, phosphatidylserine binding, phospholipid binding, protein binding, protein heterodimerization activity, protein homodimerization activity, syntaxin binding; CC: cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytosol, exocytic vesicle, glutamatergic synapse, membrane, perinuclear endoplasmic reticulum, plasma membrane, synapse, synaptic membrane, synaptic vesicle membrane
Pathways:
UniProt: Q9R0N8
Entrez ID: 54524
|
Does Knockout of Palm in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Palm
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Palm (paralemmin)
Type: protein-coding
Summary: Enables D3 dopamine receptor binding activity. Involved in several processes, including cellular response to electrical stimulus; positive regulation of dendritic spine development; and positive regulation of filopodium assembly. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; and regulation of cell shape. Located in several cellular components, including filopodium; neuron spine; and postsynaptic density. Is expressed in several structures, including eye; liver; nasal epithelium; nervous system; and renal cortex. Orthologous to human PALM (paralemmin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cellular response to electrical stimulus, cytoskeleton organization, intracellular protein localization, negative regulation of dopamine receptor signaling pathway, positive regulation of dendritic spine development, positive regulation of filopodium assembly, protein localization to plasma membrane, regulation of cell shape, regulation of postsynapse assembly, synapse maturation; CC: apicolateral plasma membrane, axon, basolateral plasma membrane, cell projection, cytoplasm, dendrite, dendrite membrane, dendritic spine, dendritic spine membrane, filopodium, filopodium membrane, glutamatergic synapse, membrane, neuron spine, nucleoplasm, plasma membrane, postsynapse, postsynaptic density, synapse, synaptic membrane
Pathways:
UniProt: Q9Z0P4
Entrez ID: 18483
|
Does Knockout of Cox11 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Cox11
|
cell proliferation
|
Regulatory T cell
|
Gene: Cox11 (cytochrome c oxidase assembly protein 11, copper chaperone)
Type: protein-coding
Summary: Predicted to enable copper ion binding activity. Acts upstream of or within negative regulation of glucokinase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 23. Orthologous to human COX11 (cytochrome c oxidase copper chaperone COX11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ATP biosynthetic process, intracellular monoatomic cation homeostasis; MF: copper ion binding, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, protein-containing complex
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Oxidative phosphorylation - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: Q6P8I6
Entrez ID: 69802
|
Does Knockout of Ccdc85b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Ccdc85b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ccdc85b (coiled-coil domain containing 85B)
Type: protein-coding
Summary: Predicted to enable delta-catenin binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of fat cell differentiation. Located in nucleus. Orthologous to human CCDC85B (coiled-coil domain containing 85B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of cell growth, negative regulation of fat cell differentiation; MF: delta-catenin binding, protein binding; CC: adherens junction, anchoring junction, centrosome, cytoplasm, cytoskeleton, nucleus
Pathways:
UniProt: Q6PDY0
Entrez ID: 240514
|
Does Knockout of Dennd2a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Dennd2a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dennd2a (DENN domain containing 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein transport, retrograde transport, endosome to Golgi; MF: guanyl-nucleotide exchange factor activity; CC: actin cytoskeleton, cytoplasm, cytoskeleton, cytosol
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q8C4S8
Entrez ID: 209773
|
Does Knockout of Cyth1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Cyth1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cyth1 (cytohesin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of epithelial cell polarity, presynaptic modulation of chemical synaptic transmission, regulation of ARF protein signal transduction; MF: guanyl-nucleotide exchange factor activity, lipid binding, protein binding; CC: adherens junction, anchoring junction, bicellular tight junction, cytoplasm, cytoplasmic side of plasma membrane, cytosol, extrinsic component of presynaptic membrane, membrane, neuromuscular junction, plasma membrane
Pathways: Endocytosis - Mus musculus (mouse), Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Phospholipase D signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q9QX11
Entrez ID: 19157
|
Does Knockout of Klra3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Klra3
|
cell cycle progression
|
breast epithelium
|
Gene: Klra3 (killer cell lectin-like receptor, subfamily A, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, signaling receptor activity; CC: cell surface, membrane, plasma membrane
Pathways: Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: Q64329
Entrez ID: 16634
|
Does Knockout of Prm1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Prm1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Prm1 (protamine 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chromosome condensation, nucleus organization, sperm DNA condensation, spermatid development, spermatogenesis; MF: DNA binding; CC: chromosome, cytosol, male germ cell nucleus, nucleoplasm, nucleosome, nucleus
Pathways:
UniProt: P02319
Entrez ID: 19118
|
Does Knockout of Sh3kbp1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Sh3kbp1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sh3kbp1 (SH3-domain kinase binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, apoptotic process, cell migration, cytoskeleton organization, endocytosis, positive regulation of B cell activation, regulation of cell shape, ubiquitin-dependent endocytosis; MF: SH3 domain binding, molecular adaptor activity, protein binding, ubiquitin protein ligase binding; CC: GABA-ergic synapse, anchoring junction, cell-cell junction, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, endocytic vesicle, focal adhesion, glutamatergic synapse, membrane, neuron projection, postsynaptic density, synapse
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Axon guidance, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, EGFR downregulation, Endocytosis - Mus musculus (mouse), Immune System, Membrane Trafficking, Negative regulation of MET activity, Nervous system development, Reelin signalling pathway, Signal Transduction, Signaling by EGFR, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Signaling by the B Cell Receptor (BCR), Vesicle-mediated transport
UniProt: Q8R550
Entrez ID: 58194
|
Does Knockout of Il7r in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Il7r
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Il7r (interleukin 7 receptor)
Type: protein-coding
Summary: Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell homeostasis, B cell proliferation, T cell differentiation, T cell homeostasis, T cell mediated cytotoxicity, cell morphogenesis, cellular homeostasis, cytokine-mediated signaling pathway, defense response to Gram-positive bacterium, hemopoiesis, interleukin-7-mediated signaling pathway, lymph node development, negative regulation of T cell apoptotic process, negative regulation of T cell mediated cytotoxicity, positive regulation of T cell differentiation in thymus, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of receptor signaling pathway via STAT, regulation of cell size; MF: cytokine receptor activity, interleukin-7 receptor activity; CC: cytosol, external side of plasma membrane, membrane, nucleoplasm, plasma membrane
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Immune System, Interleukin-7 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Membrane Trafficking, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Primary immunodeficiency - Mus musculus (mouse), Signaling by Interleukins, Vesicle-mediated transport
UniProt: P16872
Entrez ID: 16197
|
Does Knockout of Ifngr2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Ifngr2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ifngr2 (interferon gamma receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, defense response to virus, microglial cell activation, positive regulation of glutamate receptor signaling pathway, type II interferon-mediated signaling pathway, type III interferon-mediated signaling pathway; MF: cytokine receptor activity, type II interferon receptor activity; CC: membrane, plasma membrane
Pathways: Chagas disease - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), IFNG signaling activates MAPKs, Immune System, Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Regulation of IFNG signaling, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: D6RIP6, Q63953
Entrez ID: 15980
|
Does Knockout of 4731417B20Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
4731417B20Rik
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: 4731417B20Rik (RIKEN cDNA 4731417B20 gene)
Type: unknown
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 74576
|
Does Knockout of Trmt11 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Trmt11
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Trmt11 (tRNA methyltransferase 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, methylation, tRNA processing; MF: RNA binding, methyltransferase activity, nucleic acid binding, tRNA (guanine(10)-N2)-methyltransferase activity, tRNA binding, transferase activity; CC: cytoplasm, tRNA (m2G10) methyltransferase complex
Pathways:
UniProt: A0A1L1SSB7, E9QKG3, A0A1L1SQZ0, A0A1L1SVA9
Entrez ID: 73681
|
Does Knockout of Defb8 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Defb8
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Defb8 (defensin beta 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, innate immune response, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity, phosphatidylinositol-4,5-bisphosphate binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q91V82
Entrez ID: 244334
|
Does Knockout of Aqp3 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Aqp3
|
phagocytosis
|
macrophage
|
Gene: Aqp3 (aquaporin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, establishment of localization in cell, glycerol transmembrane transport, odontogenesis, polyol transmembrane transport, positive regulation of immune system process, renal water absorption, response to ischemia, response to retinoic acid, transmembrane transport, urea transmembrane transport, urea transport, water transport; MF: channel activity, glycerol channel activity, identical protein binding, polyol transmembrane transporter activity, urea transmembrane transporter activity, water channel activity; CC: basolateral plasma membrane, cell-cell junction, cytoplasm, membrane, nucleoplasm, plasma membrane
Pathways: Aquaporin-mediated transport, Passive transport by Aquaporins, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins, Vasopressin-regulated water reabsorption - Mus musculus (mouse)
UniProt: Q8R2N1
Entrez ID: 11828
|
Does Knockout of Aldh3b3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Aldh3b3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Aldh3b3 (aldehyde dehydrogenase 3 family, member B3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aldehyde metabolic process; MF: 3-chloroallyl aldehyde dehydrogenase activity, aldehyde dehydrogenase (NAD+) activity, aldehyde dehydrogenase [NAD(P)+] activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; CC: cytoplasm, membrane, plasma membrane
Pathways: Drug metabolism - cytochrome P450 - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), Histidine metabolism - Mus musculus (mouse), Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Phenylalanine metabolism - Mus musculus (mouse), Tyrosine metabolism - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse)
UniProt: J3QMK6
Entrez ID: 73458
|
Does Knockout of Ttpal in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Ttpal
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ttpal (tocopherol (alpha) transfer protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, phosphatidylinositol bisphosphate binding
Pathways:
UniProt: Q9D3D0
Entrez ID: 76080
|
Does Knockout of Rpp21 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Rpp21
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rpp21 (ribonuclease P 21 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, response to xenobiotic stimulus, tRNA 5'-leader removal, tRNA processing; MF: metal ion binding, ribonuclease P RNA binding, ribonuclease P activity; CC: endoribonuclease complex, multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8R040
Entrez ID: 67676
|
Does Knockout of Cyb5r3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Cyb5r3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cyb5r3 (cytochrome b5 reductase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol metabolic process, lipid metabolic process, nitric oxide biosynthetic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: ADP binding, AMP binding, FAD binding, NAD binding, cytochrome-b5 reductase activity, acting on NAD(P)H, flavin adenine dinucleotide binding, nitrite reductase (NO-forming) activity, oxidoreductase activity, protein binding; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, nitric-oxide synthase complex
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Biological oxidations, Immune System, Innate Immune System, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Neutrophil degranulation, Phase I - Functionalization of compounds, Vitamin C (ascorbate) metabolism
UniProt: Q9DCN2
Entrez ID: 109754
|
Does Knockout of Rpain in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,547
|
Knockout
|
Rpain
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rpain (RPA interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, DNA repair, DNA-templated DNA replication, protein import into nucleus, response to UV; MF: metal ion binding, protein-containing complex binding, zinc ion binding; CC: PML body, cytoplasm, fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: Q9CWY9
Entrez ID: 69723
|
Does Knockout of Tcf7l2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Tcf7l2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tcf7l2 (transcription factor 7 like 2, T cell specific, HMG box)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, blood vessel development, bone mineralization, canonical Wnt signaling pathway, cell differentiation, cellular response to starvation, embryonic digestive tract morphogenesis, embryonic genitalia morphogenesis, embryonic hindgut morphogenesis, face morphogenesis, fat cell differentiation, glucose homeostasis, glucose metabolic process, glycogen metabolic process, in utero embryonic development, insulin metabolic process, intracellular glucose homeostasis, maintenance of DNA repeat elements, multicellular organism growth, myoblast fate commitment, negative regulation of BMP signaling pathway, negative regulation of DNA-templated transcription, negative regulation of androgen receptor signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of fat cell differentiation, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of gluconeogenesis, negative regulation of organ growth, negative regulation of transcription by RNA polymerase II, negative regulation of type B pancreatic cell apoptotic process, neural tube development, odontogenesis of dentin-containing tooth, oligodendrocyte development, pituitary gland development, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of epithelial cell proliferation, positive regulation of epithelial to mesenchymal transition, positive regulation of gluconeogenesis, positive regulation of heparan sulfate proteoglycan biosynthetic process, positive regulation of insulin secretion, positive regulation of lipid biosynthetic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of triglyceride biosynthetic process, post-embryonic development, regulation of DNA-templated transcription, regulation of gluconeogenesis, regulation of hormone metabolic process, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of myelination, regulation of oligodendrocyte differentiation, regulation of skeletal muscle tissue development, regulation of smooth muscle cell proliferation, regulation of transcription by RNA polymerase II, response to glucose, secretory granule localization, skin development, somatic stem cell population maintenance, tissue development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, armadillo repeat domain binding, beta-catenin binding, chromatin binding, gamma-catenin binding, nuclear receptor binding, promoter-specific chromatin binding, protein binding, protein kinase binding, sequence-specific DNA binding, transcription cis-regulatory region binding, transcription corepressor binding; CC: PML body, beta-catenin-TCF complex, beta-catenin-TCF7L2 complex, catenin-TCF7L2 complex, chromatin, cytosol, nucleoplasm, nucleus, protein-DNA complex, transcription regulator complex
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Adherens junction - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Beta-catenin independent WNT signaling, Breast cancer - Mus musculus (mouse), Ca2+ pathway, Colorectal cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Developmental Biology, Endometrial cancer - Mus musculus (mouse), Formation of the beta-catenin:TCF transactivating complex, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Melanogenesis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), RNA Polymerase II Transcription, RUNX3 regulates WNT signaling, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Repression of WNT target genes, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Thyroid cancer - Mus musculus (mouse), Transcriptional regulation by RUNX3, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q924A0
Entrez ID: 21416
|
Does Knockout of Upf2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Upf2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Upf2 (UPF2 regulator of nonsense transcripts homolog (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ regeneration, liver development, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, response to unfolded protein; MF: RNA binding, telomeric DNA binding; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, exon-exon junction complex, nucleus, perinuclear region of cytoplasm
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: A2AT37
Entrez ID: 326622
|
Does Knockout of Nhlh2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Nhlh2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nhlh2 (nescient helix loop helix 2)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on apoptotic process; hypothalamus gonadotrophin-releasing hormone neuron development; and peripheral nervous system development. Acts upstream of or within several processes, including cell migration in hindbrain; male gonad development; and male mating behavior. Located in chromatin. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; head mesenchyme derived from neural crest; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Orthologous to human NHLH2 (nescient helix-loop-helix 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, cell differentiation, cell migration in hindbrain, central nervous system development, hypothalamus gonadotrophin-releasing hormone neuron development, male gonad development, male mating behavior, ovulation cycle, peripheral nervous system development, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding, transcription coactivator binding; CC: chromatin, nucleus
Pathways:
UniProt: Q64221
Entrez ID: 18072
|
Does Knockout of Ube2e3 in Regulatory T cell causally result in protein/peptide accumulation?
| 1
| 1,481
|
Knockout
|
Ube2e3
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ube2e3 (ubiquitin-conjugating enzyme E2E 3)
Type: protein-coding
Summary: Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein K11-linked ubiquitination; protein K48-linked ubiquitination; and protein K63-linked ubiquitination. Located in nucleus. Orthologous to human UBE2E3 (ubiquitin conjugating enzyme E2 E3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: negative regulation of gene expression, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein K63-linked ubiquitination, protein monoubiquitination, protein ubiquitination; MF: ATP binding, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity; CC: cytoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P52483
Entrez ID: 22193
|
Does Knockout of Zswim5 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Zswim5
|
phagocytosis
|
macrophage
|
Gene: Zswim5 (zinc finger SWIM-type containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q80TC6
Entrez ID: 74464
|
Does Knockout of Wdr25 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Wdr25
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Wdr25 (WD repeat domain 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q349
Entrez ID: 212198
|
Does Knockout of Ecm1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Ecm1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Ecm1 (extracellular matrix protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, biomineral tissue development, chondrocyte development, endochondral bone growth, inflammatory response, negative regulation of bone mineralization, negative regulation of cytokine-mediated signaling pathway, negative regulation of peptidase activity, ossification, positive regulation of angiogenesis, positive regulation of endothelial cell proliferation, regulation of T cell migration, regulation of bone mineralization, regulation of macromolecule metabolic process, regulation of primary metabolic process, regulation of transcription by RNA polymerase II, regulation of type 2 immune response, signal transduction; MF: extracellular matrix structural constituent, interleukin-2 receptor binding, protease binding, protein binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q61508
Entrez ID: 13601
|
Does Knockout of Tsen15 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Tsen15
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tsen15 (tRNA splicing endonuclease subunit 15)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. Predicted to be involved in mRNA processing and tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be located in nucleolus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2F. Orthologous to human TSEN15 (tRNA splicing endonuclease subunit 15). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, mRNA processing, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: molecular_function, nucleic acid binding; CC: cellular_component, nucleolus, nucleus
Pathways:
UniProt: Q8R3W5
Entrez ID: 66637
|
Does Knockout of Gpbar1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Gpbar1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gpbar1 (G protein-coupled bile acid receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway, cellular response to bile acid, energy homeostasis, positive regulation of ERK1 and ERK2 cascade, positive regulation of cholangiocyte proliferation, regulation of bicellular tight junction assembly, signal transduction; MF: G protein-coupled bile acid receptor activity, G protein-coupled receptor activity; CC: cytoplasm, membrane, plasma membrane, receptor complex
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Signal Transduction, Signaling by GPCR
UniProt: Q80SS6
Entrez ID: 227289
|
Does Knockout of Naga in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Naga
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Naga (N-acetyl galactosaminidase, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate catabolic process, carbohydrate metabolic process, glycolipid catabolic process, glycoside catabolic process, lipid metabolic process, oligosaccharide metabolic process; MF: alpha-N-acetylgalactosaminidase activity, alpha-galactosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, protein homodimerization activity; CC: cytoplasm, lysosome, membrane
Pathways: Glycosphingolipid biosynthesis - globo and isoglobo series - Mus musculus (mouse), Lysosome - Mus musculus (mouse)
UniProt: Q9QWR8
Entrez ID: 17939
|
Does Knockout of Aldh18a1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Aldh18a1
|
cell proliferation
|
Regulatory T cell
|
Gene: Aldh18a1 (aldehyde dehydrogenase 18 family, member A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-proline biosynthetic process, amino acid biosynthetic process, citrulline biosynthetic process, glutamate metabolic process, ornithine biosynthetic process, response to temperature stimulus; MF: ATP binding, catalytic activity, glutamate 5-kinase activity, glutamate-5-semialdehyde dehydrogenase activity, identical protein binding, kinase activity, nucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, transferase activity; CC: cytoplasm, mitochondrial matrix, mitochondrial membrane, mitochondrion
Pathways: Arginine and proline metabolism - Mus musculus (mouse), Glutamate and glutamine metabolism, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitochondrial protein degradation, citrulline biosynthesis, proline biosynthesis II, superpathway of citrulline metabolism
UniProt: Q9Z110
Entrez ID: 56454
|
Does Knockout of Pigh in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Pigh
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pigh (phosphatidylinositol glycan anchor biosynthesis, class H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process; CC: cytoplasm, endoplasmic reticulum membrane, glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Synthesis of glycosylphosphatidylinositol (GPI)
UniProt: Q5M9N4
Entrez ID: 110417
|
Does Knockout of Slc26a11 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Slc26a11
|
response to virus
|
Microglial Cell Line
|
Gene: Slc26a11 (solute carrier family 26, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, monoatomic ion transport, oxalate transport, sulfate transmembrane transport, transmembrane transport; MF: antiporter activity, chloride channel activity, chloride:bicarbonate antiporter activity, monoatomic anion transmembrane transporter activity, secondary active sulfate transmembrane transporter activity, sulfate transmembrane transporter activity; CC: Golgi apparatus, apical plasma membrane, basolateral plasma membrane, endoplasmic reticulum, lysosomal membrane, lysosome, membrane, nucleoplasm, plasma membrane
Pathways: Glycosaminoglycan metabolism, Inorganic anion exchange by SLC26 transporters, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Transport and metabolism of PAPS, Transport of small molecules
UniProt: Q80ZD3
Entrez ID: 268512
|
Does Knockout of Zcchc4 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Zcchc4
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Zcchc4 (zinc finger, CCHC domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, positive regulation of translation, rRNA methylation; MF: S-adenosyl-L-methionine binding, metal ion binding, methyltransferase activity, nucleic acid binding, rRNA (adenine-N6-)-methyltransferase activity, transferase activity, zinc ion binding; CC: cytoplasm, nucleolus, nucleus
Pathways:
UniProt: Q8BKW4
Entrez ID: 78796
|
Does Knockout of Kpna7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Kpna7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kpna7 (karyopherin subunit alpha 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, blastocyst development, epigenetic regulation of gene expression, negative regulation of gene expression, positive regulation of gene expression, protein import into nucleus, protein transport; MF: nuclear import signal receptor activity, nuclear localization sequence binding, protein binding; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytosol, female germ cell nucleus, nucleoplasm, nucleus, spindle
Pathways: Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: C0LLJ0
Entrez ID: 381686
|
Does Knockout of Npr1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Npr1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Npr1 (natriuretic peptide receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel diameter maintenance, cGMP biosynthetic process, cGMP-mediated signaling, cell surface receptor signaling pathway, cyclic nucleotide biosynthetic process, dopamine metabolic process, intracellular signal transduction, negative regulation of smooth muscle cell proliferation, positive regulation of cGMP-mediated signaling, receptor guanylyl cyclase signaling pathway, regulation of blood pressure, regulation of vascular permeability; MF: ATP binding, GTP binding, guanylate cyclase activity, hormone binding, lyase activity, natriuretic peptide receptor activity, nucleotide binding, peptide hormone binding, peptide receptor activity, phosphorus-oxygen lyase activity, protein kinase activity; CC: ANPR-A receptor complex, membrane, plasma membrane, receptor complex
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Cardiac conduction, Muscle contraction, Oxytocin signaling pathway - Mus musculus (mouse), Physiological factors, Purine metabolism - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), cyclic GMP biosynthesis
UniProt: P18293
Entrez ID: 18160
|
Does Knockout of Pde9a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Pde9a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pde9a (phosphodiesterase 9A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cGMP catabolic process, cGMP metabolic process, negative regulation of cAMP/PKA signal transduction, negative regulation of neural precursor cell proliferation, positive regulation of cardiac muscle hypertrophy, positive regulation of long-term synaptic potentiation, signal transduction; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, hydrolase activity, identical protein binding, metal ion binding, phosphoric diester hydrolase activity; CC: Golgi apparatus, cell projection, cytoplasm, cytosol, endoplasmic reticulum, membrane, nucleoplasm, perikaryon, perinuclear region of cytoplasm, plasma membrane, ruffle membrane, sarcolemma
Pathways: Hemostasis, Nitric oxide stimulates guanylate cyclase, Platelet homeostasis, Purine metabolism - Mus musculus (mouse), cGMP effects, cyclic GMP biosynthesis
UniProt: O70628
Entrez ID: 18585
|
Does Knockout of Mmgt2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Mmgt2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mmgt2 (membrane magnesium transporter 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cobalt ion transport, copper ion transmembrane transport, copper ion transport, magnesium ion transmembrane transport, magnesium ion transport, manganese ion transmembrane transport, manganese ion transport, monoatomic cation transport, nickel cation transmembrane transport, nickel cation transport; MF: cobalt ion transmembrane transporter activity, copper ion transmembrane transporter activity, inorganic cation transmembrane transporter activity, magnesium ion transmembrane transporter activity, manganese ion transmembrane transporter activity, nickel cation transmembrane transporter activity; CC: EMC complex, Golgi apparatus, Golgi membrane, cytoplasm, early endosome, early endosome membrane, endosome, membrane, plasma membrane
Pathways:
UniProt: Q8R3L0
Entrez ID: 216829
|
Does Knockout of Mir21c in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Mir21c
|
cell cycle progression
|
breast epithelium
|
Gene: Mir21c (microRNA 21c)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465212
|
Does Knockout of Zfp65 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Zfp65
|
cell proliferation
|
Regulatory T cell
|
Gene: Zfp65 (zinc finger protein 65)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8BY64, Q91W94, B8JJX9, A0A286YD24, B8JJY0
Entrez ID: 235907
|
Does Knockout of Arhgap29 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Arhgap29
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Arhgap29 (Rho GTPase activating protein 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of small GTPase mediated signal transduction, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity, PDZ domain binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8CGF1
Entrez ID: 214137
|
Does Knockout of Ndufa11 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ndufa11
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ndufa11 (NADH:ubiquinone oxidoreductase subunit A11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: A0A3B2W441, G5E814, A0A3B2W4A5
Entrez ID: 69875
|
Does Knockout of Eif5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Eif5
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Eif5 (eukaryotic translation initiation factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: formation of cytoplasmic translation initiation complex, regulation of translational initiation, ribosome assembly, translation, translational initiation; MF: GDP-dissociation inhibitor activity, GTP binding, GTPase activator activity, eukaryotic initiation factor eIF2 binding, nucleotide binding, translation initiation factor activity; CC: cytoplasm, cytosol, plasma membrane, synapse
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, GTP hydrolysis and joining of the 60S ribosomal subunit, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation
UniProt: P59325
Entrez ID: 217869
|
Does Knockout of Paxip1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,537
|
Knockout
|
Paxip1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Paxip1 (PAX interacting (with transcription-activation domain) protein 1)
Type: protein-coding
Summary: This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-strand breaks and is necessary for progression through cell division. The protein also functions in the regulation of transcription by recruiting histone methyltransferases to gene promoters bound by the sequence-specific transcription factor paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013].
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA recombination, DNA repair, adipose tissue development, chorion development, chromatin remodeling, endothelial cell migration, negative regulation of DNA-binding transcription factor activity, positive regulation of isotype switching, positive regulation of isotype switching to IgG isotypes, positive regulation of protein ubiquitination, positive regulation of transcription initiation by RNA polymerase II, regulation of cell cycle G2/M phase transition, response to ionizing radiation, vasculogenesis; CC: MLL3/4 complex, chromosome, histone methyltransferase complex, nuclear matrix, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Nonhomologous End-Joining (NHEJ)
UniProt: Q6NZQ4
Entrez ID: 55982
|
Does Knockout of Clcn2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Clcn2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Clcn2 (chloride channel, voltage-sensitive 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acinar cell differentiation, cell differentiation involved in salivary gland development, cellular hypotonic response, chloride transmembrane transport, chloride transport, lung development, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, phagocytosis, engulfment, positive regulation of oligodendrocyte differentiation, regulation of aldosterone biosynthetic process, regulation of biological quality, regulation of membrane depolarization during action potential, regulation of resting membrane potential, retina development in camera-type eye, stabilization of membrane potential, transmembrane transport; MF: chloride channel activity, chloride channel regulator activity, chloride transmembrane transporter activity, protein binding, voltage-gated chloride channel activity, voltage-gated monoatomic anion channel activity, volume-sensitive chloride channel activity; CC: astrocyte end-foot, axon, axon initial segment, basolateral plasma membrane, cell projection, chloride channel complex, dendrite, dendritic spine membrane, membrane, monoatomic ion channel complex, myelin sheath, perikaryon, plasma membrane, postsynaptic membrane, synapse
Pathways: Ion channel transport, Mineral absorption - Mus musculus (mouse), Stimuli-sensing channels, Transport of small molecules
UniProt: Q9R0A1
Entrez ID: 12724
|
Does Knockout of Nln in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Nln
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nln (neurolysin (metallopeptidase M3 family))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: peptide catabolic process, peptide metabolic process, protein catabolic process, proteolysis, regulation of gluconeogenesis, regulation of skeletal muscle fiber differentiation; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, oligopeptidase activity, peptidase activity, peptide binding; CC: cytoplasm, cytosol, mitochondrial intermembrane space, mitochondrion, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), GPCR ligand binding, Peptide ligand-binding receptors, Renin-angiotensin system - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q91YP2
Entrez ID: 75805
|
Does Knockout of Rps6ka5 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Rps6ka5
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Rps6ka5 (ribosomal protein S6 kinase, polypeptide 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, chromatin remodeling, inflammatory response, interleukin-1-mediated signaling pathway, intracellular signal transduction, negative regulation of DNA-templated transcription, positive regulation of NF-kappaB transcription factor activity, positive regulation of transcription by RNA polymerase II, post-translational protein modification, protein phosphorylation, regulation of DNA-templated transcription, regulation of postsynapse organization; MF: ATP binding, histone H2AS1 kinase activity, histone H3S10 kinase activity, histone H3S28 kinase activity, kinase activity, magnesium ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Axon guidance, Bladder cancer - Mus musculus (mouse), C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, CREB phosphorylation, Circadian entrainment - Mus musculus (mouse), Cytokine Signaling in Immune system, Developmental Biology, ERK/MAPK targets, Immune System, Innate Immune System, Interleukin-17 signaling, MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, MicroRNAs in cancer - Mus musculus (mouse), MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NCAM signaling for neurite out-growth, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Nuclear Events (kinase and transcription factor activation), Pathways in cancer - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q8C050
Entrez ID: 73086
|
Does Knockout of Prx in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Prx
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Prx (periaxin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: peripheral nervous system myelin formation, peripheral nervous system myelin maintenance, regulation of RNA splicing, sensory perception of pain, transmission of nerve impulse; CC: anchoring junction, cytoplasm, cytosol, membrane, nuclear speck, nucleus, plasma membrane
Pathways:
UniProt: O55103
Entrez ID: 19153
|
Does Knockout of Dnmbp in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Dnmbp
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Dnmbp (dynamin binding protein)
Type: protein-coding
Summary: This gene encodes a member of the DBL family of guanine nucleotide exchange factors. The encoded protein has been proposed to regulate the actin cytoskeleton by specifically activating the Rho-family GTPase Cdc42. An interaction between the encoded protein and a Listeria protein has been shown to mediate Listeria infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cilium assembly, intracellular signal transduction, regulation of cell shape; MF: guanyl-nucleotide exchange factor activity, protein binding; CC: Golgi apparatus, Golgi stack, anchoring junction, cell-cell junction, cytoplasm, cytoskeleton, cytosol, nuclear body, nucleolus, nucleoplasm, presynapse, synapse, synaptic vesicle
Pathways: CDC42 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6TXD4
Entrez ID: 71972
|
Does Knockout of Trpc3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Trpc3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Trpc3 (transient receptor potential cation channel, subfamily C, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of calcium ion transport into cytosol, positive regulation of cardiac muscle hypertrophy in response to stress, regulation of cytosolic calcium ion concentration, response to ATP, response to calcium ion, single fertilization, transmembrane transport; MF: calcium channel activity, calcium-activated cation channel activity, inositol 1,4,5 trisphosphate binding, metal ion binding, monoatomic ion channel activity, protein binding, store-operated calcium channel activity; CC: cation channel complex, membrane, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse), Effects of PIP2 hydrolysis, Elevation of cytosolic Ca2+ levels, G alpha (q) signalling events, GPCR downstream signalling, Hemostasis, Ion channel transport, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet calcium homeostasis, Platelet homeostasis, Signal Transduction, Signaling by GPCR, Spinocerebellar ataxia - Mus musculus (mouse), Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q9QZC1
Entrez ID: 22065
|
Does Knockout of Gm10797 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Gm10797
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gm10797 (predicted gene 10797)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Zbtb6 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Zbtb6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zbtb6 (zinc finger and BTB domain containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q8K088
Entrez ID: 241322
|
Does Knockout of 4933402N03Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
4933402N03Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: 4933402N03Rik (RIKEN cDNA 4933402N03 gene)
Type: protein-coding
Summary: Orthologous to human C10orf120 (chromosome 10 open reading frame 120). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q8CDT9
Entrez ID: 233918
|
Does Knockout of Morn3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Morn3
|
cell cycle progression
|
breast epithelium
|
Gene: Morn3 (MORN repeat containing 3)
Type: protein-coding
Summary: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in negative regulation of signal transduction by p53 class mediator. Predicted to be located in acrosomal vesicle. Is expressed in lung. Orthologous to human MORN3 (MORN repeat containing 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: biological_process, negative regulation of signal transduction by p53 class mediator, signal transduction by p53 class mediator; MF: molecular_function, protein-macromolecule adaptor activity; CC: acrosomal vesicle, cytoplasmic vesicle
Pathways:
UniProt: Q8C5T4
Entrez ID: 74890
|
Does Knockout of Sfxn3 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 2,474
|
Knockout
|
Sfxn3
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Sfxn3 (sideroflexin 3)
Type: protein-coding
Summary: Predicted to enable L-serine transmembrane transporter activity. Predicted to be involved in serine import into mitochondrion. Located in mitochondrion. Orthologous to human SFXN3 (sideroflexin 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: L-serine transport, amino acid transport, mitochondrial transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, one-carbon metabolic process, serine import into mitochondrion, transmembrane transport; MF: L-serine transmembrane transporter activity, monoatomic ion transmembrane transporter activity, transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q91V61
Entrez ID: 94280
|
Does Knockout of Fuca2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Fuca2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fuca2 (fucosidase, alpha-L- 2, plasma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, fucose metabolic process, glycoside catabolic process, regulation of entry of bacterium into host cell, response to bacterium; MF: alpha-L-fucosidase activity, fucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds; CC: extracellular region, extracellular space, lysosome
Pathways: Immune System, Innate Immune System, Lysosome - Mus musculus (mouse), Metabolism of proteins, Neutrophil degranulation, Other glycan degradation - Mus musculus (mouse), Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q99KR8
Entrez ID: 66848
|
Does Knockout of Tnrc18 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Tnrc18
|
phagocytosis
|
macrophage
|
Gene: Tnrc18 (trinucleotide repeat containing 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein localization to chromatin, transposable element silencing by heterochromatin formation; MF: chromatin binding, chromatin-protein adaptor activity, histone H3K9me2/3 reader activity; CC: chromatin, cytosol, mitochondrion, nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: Q80WC3
Entrez ID: 231861
|
Does Knockout of P4htm in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,493
|
Knockout
|
P4htm
|
cell proliferation
|
Melanoma Cell Line
|
Gene: P4htm (prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of erythrocyte differentiation; MF: 2-oxoglutarate-dependent dioxygenase activity, L-ascorbic acid binding, calcium ion binding, dioxygenase activity, hypoxia-inducible factor-proline dioxygenase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, procollagen-proline 4-dioxygenase activity, zinc ion binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8BG58
Entrez ID: 74443
|
Does Knockout of Spout1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Spout1
|
cell cycle progression
|
breast epithelium
|
Gene: Spout1 (SPOUT domain containing methyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, maintenance of centrosome location, methylation, miRNA processing, post-transcriptional regulation of gene expression, rRNA base methylation, rRNA processing; MF: S-adenosyl-L-methionine binding, methyltransferase activity, miRNA binding, rRNA (uridine-N3-)-methyltransferase activity, transferase activity; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, kinetochore, mitotic spindle, spindle, spindle pole centrosome
Pathways:
UniProt: Q3UHX9
Entrez ID: 227695
|
Does Knockout of Zfp959 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Zfp959
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp959 (zinc finger protein 959)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: A0A286YE35, Q91VM8
Entrez ID: 224893
|
Does Knockout of Prdm4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Prdm4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prdm4 (PR domain containing 4)
Type: protein-coding
Summary: This gene encodes a member of the PR/SET family of zinc finger proteins. This protein has been shown to bind DNA in a sequence-specific manner and has been implicated in neural stem cell proliferation and differentiation. Pseudogenes have been identified on chromosomes 14 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: methylation, negative regulation of cell growth, negative regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulation of neural precursor cell proliferation, regulation of stem cell differentiation, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, death receptor binding, histone methyltransferase binding, metal ion binding, methyltransferase activity, sequence-specific double-stranded DNA binding, transferase activity, zinc ion binding; CC: cytoplasm, histone methyltransferase complex, nucleus
Pathways: Neurotrophin signaling pathway - Mus musculus (mouse)
UniProt: Q80V63
Entrez ID: 72843
|
Does Knockout of Trim29 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Trim29
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Trim29 (tripartite motif-containing 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, innate immune response, negative regulation of protein localization to nucleus, negative regulation of transcription by RNA polymerase II; MF: identical protein binding, metal ion binding, p53 binding, protein binding, zinc ion binding; CC: cytoplasm, lysosome
Pathways:
UniProt: Q8R2Q0
Entrez ID: 72169
|
Does Knockout of Miga2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Miga2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Miga2 (mitoguardin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone development, mitochondrial fusion; MF: protein heterodimerization activity, protein homodimerization activity; CC: membrane, mitochondrial outer membrane, mitochondrion, plasma membrane
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA
UniProt: Q8BK03
Entrez ID: 108958
|
Does Knockout of Dynlt1a in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Dynlt1a
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dynlt1a (dynein light chain Tctex-type 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, Salmonella infection - Mus musculus (mouse)
UniProt: P51807
Entrez ID: 100310872
|
Does Knockout of Msx1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,685
|
Knockout
|
Msx1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Msx1 (msh homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, activation of meiosis, anterior/posterior pattern specification, bone morphogenesis, cartilage development, cartilage morphogenesis, cell morphogenesis, cell surface receptor signaling pathway involved in heart development, cellular response to nicotine, embryonic digit morphogenesis, embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, embryonic morphogenesis, embryonic nail plate morphogenesis, epithelial to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, face morphogenesis, forebrain development, heart development, heart morphogenesis, in utero embryonic development, inner ear development, mammary gland epithelium development, mesenchymal cell apoptotic process, mesenchymal cell proliferation, midbrain development, middle ear morphogenesis, muscle organ development, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of epithelial cell differentiation, negative regulation of gene expression, negative regulation of odontoblast differentiation, negative regulation of striated muscle cell differentiation, negative regulation of transcription by RNA polymerase II, nose development, odontogenesis, odontogenesis of dentin-containing tooth, pituitary gland development, positive regulation of BMP signaling pathway, positive regulation of cell cycle, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of mesenchymal cell apoptotic process, positive regulation of odontogenesis, positive regulation of transcription by RNA polymerase II, protein localization to nucleus, protein stabilization, regulation of DNA-templated transcription, regulation of odontogenesis, regulation of transcription by RNA polymerase II, roof of mouth development, signal transduction involved in regulation of gene expression, stem cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, p53 binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: nuclear periphery, nucleoplasm, nucleus, transcription regulator complex
Pathways: Human T-cell leukemia virus 1 infection - Mus musculus (mouse)
UniProt: P13297
Entrez ID: 17701
|
Does Knockout of Vps51 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Vps51
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Vps51 (VPS51 GARP complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, Golgi vesicle transport, autophagy, brain morphogenesis, endocytic recycling, lipid transport, lysosomal transport, protein targeting, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated cholesterol transport; CC: EARP complex, GARP complex, Golgi apparatus, cytosol, endosome, membrane, nucleolus, recycling endosome, trans-Golgi network
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q3UVL4
Entrez ID: 68505
|
Does Knockout of Ndufs4 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Ndufs4
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ndufs4 (NADH:ubiquinone oxidoreductase core subunit S4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult behavior, adult walking behavior, aerobic respiration, brain development, cellular response to oxygen levels, cognition, dopamine metabolic process, electron transport chain, inflammatory response, innate immune response, mitochondrial respiratory chain complex I assembly, neuron apoptotic process, neuron development, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport, psychomotor behavior, reactive oxygen species metabolic process, regulation of mitochondrial membrane potential, respiratory electron transport chain, respiratory system process, response to cAMP, response to injury involved in regulation of muscle adaptation, sensory perception of sound, tricarboxylic acid cycle, visual perception; MF: NADH dehydrogenase (ubiquinone) activity; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CXZ1
Entrez ID: 17993
|
Does Knockout of Fcho1 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Fcho1
|
phagocytosis
|
macrophage
|
Gene: Fcho1 (FCH domain only 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, clathrin coat assembly, clathrin-dependent endocytosis, endocytosis, positive regulation of T cell activation; MF: AP-2 adaptor complex binding, protein binding; CC: clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytosol, membrane, nucleoplasm, plasma membrane, postsynaptic endocytic zone
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q8K285
Entrez ID: 74015
|
Does Knockout of H2al1k in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
H2al1k
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: H2al1k (H2A histone family member L1K)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chromosome organization, heterochromatin formation, spermatogenesis; MF: DNA binding, protein heterodimerization activity, structural constituent of chromatin; CC: chromosome, nucleosome, nucleus, pericentric heterochromatin
Pathways: Alcoholism - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse)
UniProt: J3QP08
Entrez ID: 547154
|
Does Knockout of Tnks2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Tnks2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tnks2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)
Type: protein-coding
Summary: Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Acts upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; eye; and genitourinary system. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, multicellular organism growth, negative regulation of telomere maintenance via telomere lengthening, positive regulation of canonical Wnt signaling pathway, positive regulation of telomere capping, protein auto-ADP-ribosylation, protein localization to chromosome, telomeric region, protein poly-ADP-ribosylation, protein polyubiquitination, regulation of multicellular organism growth, telomere maintenance; MF: NAD+ poly-ADP-ribosyltransferase activity, NAD+-protein mono-ADP-ribosyltransferase activity, NAD+-protein-aspartate ADP-ribosyltransferase activity, NAD+-protein-glutamate ADP-ribosyltransferase activity, enzyme binding, glycosyltransferase activity, metal ion binding, nucleotidyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, chromosome, chromosome, telomeric region, cytoplasm, membrane, nuclear envelope, nucleus, pericentriolar material, perinuclear region of cytoplasm
Pathways: Degradation of AXIN, Deubiquitination, Intracellular signaling by second messengers, Metabolism of proteins, PIP3 activates AKT signaling, PTEN Regulation, Post-translational protein modification, Regulation of PTEN stability and activity, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Ub-specific processing proteases
UniProt: Q3UES3
Entrez ID: 74493
|
Does Knockout of Ndst1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Ndst1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ndst1 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, aorta development, cardiac septum development, cell population proliferation, coronary vasculature development, embryonic neurocranium morphogenesis, embryonic viscerocranium morphogenesis, fibroblast growth factor receptor signaling pathway, forebrain development, glycosaminoglycan metabolic process, heart development, heparan sulfate proteoglycan biosynthetic process, heparin proteoglycan biosynthetic process, inflammatory response, midbrain development, polysaccharide biosynthetic process, positive regulation of MAPK cascade, positive regulation of smoothened signaling pathway, respiratory gaseous exchange by respiratory system; MF: N-acetylglucosamine deacetylase activity, catalytic activity, deacetylase activity, heparan sulfate N-deacetylase activity, heparan sulfate N-sulfotransferase activity, hydrolase activity, protein binding, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane, trans-Golgi network membrane
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q3UHN9
Entrez ID: 15531
|
Does Knockout of Cdh7 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Cdh7
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cdh7 (cadherin 7, type 2)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related cadherin gene on chromosome 1. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: adherens junction organization, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, homophilic cell adhesion via plasma membrane adhesion molecules; MF: beta-catenin binding, cadherin binding, calcium ion binding, metal ion binding; CC: adherens junction, catenin complex, membrane, plasma membrane
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization
UniProt: Q8BM92
Entrez ID: 241201
|
Does Knockout of Ddx24 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Ddx24
|
cell proliferation
|
Regulatory T cell
|
Gene: Ddx24 (DEAD box helicase 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: cytoplasm, nucleolus, nucleus
Pathways:
UniProt: Q9ESV0
Entrez ID: 27225
|
Does Knockout of Gm6455 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm6455
|
phagocytosis
|
macrophage
|
Gene: Gm6455 (predicted gene 6455)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 623849
|
Does Knockout of Pla2g2c in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Pla2g2c
|
cell cycle progression
|
breast epithelium
|
Gene: Pla2g2c (phospholipase A2, group IIC)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate secretion, lipid catabolic process, lipid metabolic process, phosphatidylcholine metabolic process, phosphatidylglycerol metabolic process, phospholipid catabolic process, phospholipid metabolic process; MF: calcium ion binding, calcium-dependent phospholipase A2 activity, hydrolase activity, metal ion binding, phospholipase A2 activity, phospholipid binding, signaling receptor binding; CC: cellular_component, extracellular region
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Ether lipid metabolism - Mus musculus (mouse), Fat digestion and absorption - Mus musculus (mouse), Glycerophospholipid metabolism - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), phospholipases
UniProt: P48076
Entrez ID: 18781
|
Does Knockout of Ehmt2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Ehmt2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ehmt2 (euchromatic histone lysine N-methyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, behavioral response to cocaine, cellular response to cocaine, cellular response to starvation, chromatin organization, epigenetic regulation of gene expression, fertilization, long-term memory, methylation, negative regulation of DNA-templated transcription, negative regulation of autophagosome assembly, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, neuron fate specification, oocyte development, organ growth, peptidyl-lysine dimethylation, phenotypic switching, regulation of DNA replication, regulation of protein modification process, regulation of transcription by RNA polymerase II, spermatid development, synaptonemal complex assembly; MF: C2H2 zinc finger domain binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, histone H3K27 methyltransferase activity, histone H3K56 methyltransferase activity, histone H3K9 methyltransferase activity, histone H3K9me2 methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, p53 binding, promoter-specific chromatin binding, protein binding, protein-lysine N-methyltransferase activity, transcription corepressor binding, transferase activity, zinc ion binding; CC: chromatin, chromosome, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways: Longevity regulating pathway - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse)
UniProt: Q9Z148
Entrez ID: 110147
|
Does Knockout of Myo5b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Myo5b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Myo5b (myosin VB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, dendritic spine morphogenesis, endocytosis, endosomal transport, modulation of chemical synaptic transmission, neurotransmitter receptor transport, endosome to plasma membrane, positive regulation of axon extension, positive regulation of dendrite morphogenesis, positive regulation of exosomal secretion, positive regulation of protein localization to plasma membrane, protein transmembrane transport, protein transport, regulation of modification of postsynaptic structure, regulation of protein localization, synaptic vesicle recycling via endosome, vesicle-mediated transport, vesicle-mediated transport in synapse; MF: ATP binding, ATP hydrolysis activity, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, ionotropic glutamate receptor binding, microfilament motor activity, nucleotide binding, protein binding, small GTPase binding; CC: Schaffer collateral - CA1 synapse, actin cytoskeleton, apical cortex, brush border, cytoplasm, dendritic spine, glutamatergic synapse, membrane, myosin complex, neuronal cell body, perinuclear region of cytoplasm, postsynapse, postsynaptic actin cytoskeleton, postsynaptic recycling endosome membrane, protein-containing complex, recycling endosome
Pathways:
UniProt: H3BLK6, G5E8G6, D3Z135, G3X9Y9
Entrez ID: 17919
|
Does Knockout of Sfr1 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Sfr1
|
response to virus
|
Microglial Cell Line
|
Gene: Sfr1 (SWI5 dependent recombination repair 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to estrogen stimulus, double-strand break repair via homologous recombination, positive regulation of DNA-templated transcription; MF: transcription coactivator activity; CC: Swi5-Sfr1 complex, centrosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8BP27
Entrez ID: 67788
|
Does Knockout of Aagab in Neuroblastoma Cell Line causally result in response to virus?
| 1
| 1,422
|
Knockout
|
Aagab
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Aagab (alpha- and gamma-adaptin binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein transport; CC: cytoplasm, cytosol, nuclear speck
Pathways:
UniProt: Q8R2R3
Entrez ID: 66939
|
Does Knockout of Ccnk in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Ccnk
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ccnk (cyclin K)
Type: protein-coding
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Acts upstream of or within in utero embryonic development and negative regulation of stem cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of cyclin K-CDK12 complex; cyclin K-CDK13 complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; olfactory epithelium; and retina nuclear layer. Orthologous to human CCNK (cyclin K). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, cell division, host-mediated suppression of viral genome replication, in utero embryonic development, negative regulation of stem cell differentiation, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of signal transduction, regulation of transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein kinase binding; CC: cyclin K-CDK12 complex, cyclin K-CDK13 complex, cyclin/CDK positive transcription elongation factor complex, nucleoplasm, nucleus
Pathways:
UniProt: Q3U3M5
Entrez ID: 12454
|
Does Knockout of Psmc3 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Psmc3
|
cell proliferation
|
Regulatory T cell
|
Gene: Psmc3 (proteasome (prosome, macropain) 26S subunit, ATPase 3)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and proteasome-activating activity. Acts upstream of or within blastocyst development. Located in P-body. Part of proteasome accessory complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: blastocyst development, host-mediated perturbation of viral transcription, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, identical protein binding, nucleotide binding, proteasome-activating activity; CC: P-body, cytoplasm, nucleus, perinuclear region of cytoplasm, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: O88685
Entrez ID: 19182
|
Does Knockout of Ngef in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Ngef
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Ngef (neuronal guanine nucleotide exchange factor)
Type: protein-coding
Summary: Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway; negative regulation of dendritic spine morphogenesis; and regulation of synapse pruning. Is active in glutamatergic synapse. Is expressed in several structures, including brain; chondrocranium; genitourinary system; heart valve; and liver. Orthologous to human NGEF (neuronal guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, ephrin receptor signaling pathway, negative regulation of dendritic spine morphogenesis, nervous system development, regulation of GTPase activity, regulation of actin cytoskeleton organization, regulation of synapse pruning; MF: ephrin receptor binding, guanyl-nucleotide exchange factor activity, protein binding; CC: cell projection, cytoplasm, cytosol, glutamatergic synapse, growth cone, membrane, postsynapse
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), CDC42 GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, Developmental Biology, EPH-Ephrin signaling, EPHA-mediated growth cone collapse, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, Nervous system development, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling
UniProt: Q8CHT1
Entrez ID: 53972
|
Does Knockout of 1810009J06Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
1810009J06Rik
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: 1810009J06Rik (RIKEN cDNA 1810009J06 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
Pathways: Influenza A - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q9CPN7
Entrez ID: 73626
|
Does Knockout of Fer in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Fer
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Fer (FER tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Fc-epsilon receptor signaling pathway, Kit signaling pathway, Sertoli cell development, actin cytoskeleton organization, adherens junction assembly, adherens junction disassembly, cell adhesion, cell-cell adhesion mediated by cadherin, cellular response to macrophage colony-stimulating factor stimulus, cellular response to reactive oxygen species, chemotaxis, cytokine-mediated signaling pathway, diapedesis, extracellular matrix-cell signaling, germ cell development, insulin receptor signaling pathway, interleukin-6-mediated signaling pathway, male gonad development, microtubule cytoskeleton organization, negative regulation of mast cell activation involved in immune response, peptidyl-tyrosine phosphorylation, platelet-derived growth factor receptor signaling pathway, positive regulation of NF-kappaB transcription factor activity, positive regulation of actin filament polymerization, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of epidermal growth factor receptor signaling pathway, regulation of fibroblast migration, regulation of lamellipodium assembly, regulation of protein phosphorylation, response to lipopolysaccharide, response to platelet-derived growth factor, seminiferous tubule development, signal transduction, substrate adhesion-dependent cell spreading; MF: ATP binding, epidermal growth factor receptor binding, kinase activity, lipid binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein phosphatase 1 binding, protein tyrosine kinase activity, transferase activity; CC: actin cytoskeleton, adherens junction, anchoring junction, cell cortex, cell junction, cell projection, chromatin, cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, lamellipodium, membrane, microtubule cytoskeleton, nucleus, plasma membrane, protein-containing complex
Pathways: Adherens junction - Mus musculus (mouse), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT
UniProt: P70451
Entrez ID: 14158
|
Does Knockout of Nol10 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Nol10
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Nol10 (nucleolar protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleolus, nucleus, small-subunit processome
Pathways:
UniProt: Q5RJG1
Entrez ID: 217431
|
Does Knockout of F8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
F8
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: F8 (coagulation factor VIII)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acute-phase response, blood coagulation, blood coagulation, intrinsic pathway, hemostasis; MF: copper ion binding, metal ion binding, oxidoreductase activity; CC: extracellular region, extracellular space, platelet alpha granule
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, Common Pathway of Fibrin Clot Formation, Complement and coagulation cascades - Mus musculus (mouse), ER to Golgi Anterograde Transport, Formation of Fibrin Clot (Clotting Cascade), Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hemostasis, Intrinsic Pathway of Fibrin Clot Formation, Membrane Trafficking, Metabolism of proteins, Platelet activation, signaling and aggregation, Platelet degranulation , Post-translational protein modification, Response to elevated platelet cytosolic Ca2+, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q06194
Entrez ID: 14069
|
Does Knockout of Rrs1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Rrs1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rrs1 (ribosome biogenesis regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), hematopoietic progenitor cell differentiation, mitotic metaphase chromosome alignment, protein localization to nucleolus, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis; MF: 5S rRNA binding, protein binding; CC: condensed nuclear chromosome, endoplasmic reticulum, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q9CYH6
Entrez ID: 59014
|
Does Knockout of Gucy1b2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Gucy1b2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Gucy1b2 (guanylate cyclase 1, soluble, beta 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cGMP biosynthetic process, cGMP-mediated signaling, cyclic nucleotide biosynthetic process, intracellular signal transduction, response to oxygen levels; MF: GTP binding, guanylate cyclase activity, heme binding, lyase activity, nitric oxide binding, nucleotide binding, phosphorus-oxygen lyase activity; CC: cytoplasm, cytosol, guanylate cyclase complex, soluble
Pathways: Circadian entrainment - Mus musculus (mouse), Gap junction - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Muscle contraction, Oxytocin signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Smooth Muscle Contraction, Vascular smooth muscle contraction - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), cyclic GMP biosynthesis
UniProt: E9Q6H0, Q8BXH3
Entrez ID: 239134
|
Does Knockout of Pcdhb9 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Pcdhb9
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pcdhb9 (protocadherin beta 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: E9Q5G2, Q91XZ1, Q8CCK1
Entrez ID: 93880
|
Does Knockout of Pank2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Pank2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pank2 (pantothenate kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, angiogenesis, coenzyme A biosynthetic process, mitochondrion organization, regulation of bile acid metabolic process, regulation of fatty acid metabolic process, regulation of mitochondrial membrane potential, regulation of triglyceride metabolic process, spermatid development; MF: ATP binding, kinase activity, nucleotide binding, pantothenate kinase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrial intermembrane space, mitochondrion, nucleus
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Vitamin B5 (pantothenate) metabolism
UniProt: Q7M753
Entrez ID: 74450
|
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