prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Vmn1r149 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Vmn1r149
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Vmn1r149 (vomeronasal 1 receptor 149)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: E9PWL6
Entrez ID: 100043051
|
Does Knockout of Ranbp2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Ranbp2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ranbp2 (RAN binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, centrosome localization, cytoplasmic pattern recognition receptor signaling pathway, intracellular glucose homeostasis, mRNA transport, negative regulation of RNA export from nucleus, negative regulation of innate immune response, nuclear export, nucleocytoplasmic transport, protein folding, protein sumoylation, protein transport, regulation of gluconeogenesis, response to amphetamine, toll-like receptor signaling pathway; MF: GTPase activator activity, RNA binding, SUMO ligase activity, SUMO transferase activity, kinase activator activity, metal ion binding, peptidyl-prolyl cis-trans isomerase activity, protein binding, protein-containing complex binding, small GTPase binding, transferase activity, zinc ion binding; CC: SUMO ligase complex, annulate lamellae, cytoplasm, cytoplasmic periphery of the nuclear pore complex, cytosol, membrane, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear pore, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q9ERU9
Entrez ID: 19386
|
Does Knockout of 4930571K23Rik in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
4930571K23Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 4930571K23Rik (RIKEN cDNA 4930571K23 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 75861
|
Does Knockout of Fam184a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Fam184a
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Fam184a (family with sequence similarity 184, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: P-body, centriolar satellite, ciliary basal body, cytosol
Pathways:
UniProt: E9QAL2, E9PW83, F6R487, A0A1W2P7N4, A0A1W2P6N4, F6ZCT9, F6RSY8, A0A1W2P6K1, F6TU77, A0A1W2P7W6
Entrez ID: 75906
|
Does Knockout of Brca2 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Brca2
|
phagocytosis
|
macrophage
|
Gene: Brca2 (breast cancer 2, early onset)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA recombination, DNA repair, brain development, cell population proliferation, cellular response to ionizing radiation, cellular senescence, centrosome duplication, chordate embryonic development, chromatin remodeling, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, establishment of protein localization to telomere, female gonad development, hematopoietic stem cell proliferation, hemopoiesis, homologous chromosome orientation in meiotic metaphase I, inner cell mass cell proliferation, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, male meiosis I, mammary gland development, meiosis I, mitotic recombination-dependent replication fork processing, multicellular organism growth, negative regulation of mammary gland epithelial cell proliferation, nucleotide-excision repair, oocyte maturation, positive regulation of DNA-templated transcription, positive regulation of mitotic cell cycle, regulation of DNA damage checkpoint, regulation of DNA-templated transcription, regulation of cytokinesis, replication fork processing, response to UV-C, response to X-ray, response to gamma radiation, spermatogenesis, stem cell proliferation, telomere maintenance via recombination; MF: DNA binding, gamma-tubulin binding, histone H3 acetyltransferase activity, histone H4 acetyltransferase activity, identical protein binding, protease binding, protein binding, single-stranded DNA binding; CC: BRCA2-MAGE-D1 complex, DNA repair complex, centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, cytosol, lateral element, nuclear ubiquitin ligase complex, nucleoplasm, nucleus, protein-containing complex, secretory granule
Pathways: Breast cancer - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through MMEJ (alt-NHEJ), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Presynaptic phase of homologous DNA pairing and strand exchange, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: P97929
Entrez ID: 12190
|
Does Knockout of Trappc1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Trappc1
|
cell proliferation
|
Regulatory T cell
|
Gene: Trappc1 (trafficking protein particle complex 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, cytoplasm, endoplasmic reticulum
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q5NCF2
Entrez ID: 245828
|
Does Knockout of Otx1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Otx1
|
cell proliferation
|
Regulatory T cell
|
Gene: Otx1 (orthodenticle homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the bicoid subfamily of the paired homeobox transcription factor family. The encoded protein is critical to the maintenance and regionalization of the forebrain and midbrain during development. It may also have important functions in sense organ development, pituitary function, and in the regulation of blood cell production. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anterior/posterior pattern specification, diencephalon morphogenesis, forebrain development, inner ear morphogenesis, metencephalon development, midbrain development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways: Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: P80205
Entrez ID: 18423
|
Does Knockout of Cox6a1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Cox6a1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cox6a1 (cytochrome c oxidase subunit 6A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; MF: enzyme regulator activity, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, myelin sheath, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: P43024
Entrez ID: 12861
|
Does Knockout of Anks4b in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Anks4b
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Anks4b (ankyrin repeat and sterile alpha motif domain containing 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brush border assembly, cell differentiation, protein localization to microvillus, protein-containing complex assembly, response to endoplasmic reticulum stress; CC: brush border, cell projection, endoplasmic reticulum membrane, microvillus, plasma membrane, plasma membrane bounded cell projection
Pathways:
UniProt: Q8K3X6
Entrez ID: 72074
|
Does Knockout of Mfsd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Mfsd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mfsd1 (major facilitator superfamily domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dipeptide transmembrane transport, dipeptide transmembrane transport from lysosomal lumen to cytosol, protein localization to lysosome, protein stabilization, transmembrane transport; MF: dipeptide uniporter activity, protein binding, protein homodimerization activity, transmembrane transporter activity; CC: lysosomal membrane, lysosome, membrane
Pathways:
UniProt: Q9DC37
Entrez ID: 66868
|
Does Knockout of Epha10 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Epha10
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Epha10 (Eph receptor A10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell surface receptor protein tyrosine kinase signaling pathway, ephrin receptor signaling pathway; MF: ATP binding, ephrin receptor activity, kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity; CC: dendrite, membrane, plasma membrane
Pathways: Axon guidance, Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, Nervous system development
UniProt: Q8BYG9
Entrez ID: 230735
|
Does Knockout of Htt in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Htt
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Htt (huntingtin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled dopamine receptor signaling pathway, Golgi organization, anatomical structure morphogenesis, anterior/posterior pattern specification, associative learning, axo-dendritic transport, brain development, cellular senescence, central nervous system development, citrulline metabolic process, determination of adult lifespan, endoplasmic reticulum organization, endoplasmic reticulum to Golgi vesicle-mediated transport, endosomal transport, establishment of mitotic spindle orientation, gastrulation, gene expression, grooming behavior, hormone metabolic process, insulin secretion, lactate biosynthetic process from pyruvate, learning, learning or memory, locomotory behavior, mRNA transport, microtubule depolymerization, microtubule-based process, mitochondrial transport, mitochondrion organization, multicellular organismal-level iron ion homeostasis, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, neural plate formation, neurogenesis, neuron development, olfactory lobe development, paraxial mesoderm formation, peptide hormone secretion, positive regulation of CAMKK-AMPK signaling cascade, positive regulation of aggrephagy, positive regulation of apoptotic process, positive regulation of cilium assembly, positive regulation of lipophagy, positive regulation of mitophagy, positive regulation of motile cilium assembly, positive regulation of non-motile cilium assembly, postsynapse to nucleus signaling pathway, protein destabilization, protein localization to centrosome, protein localization to nucleus, quinolinate biosynthetic process, regulation of CAMKK-AMPK signaling cascade, regulation of gene expression, regulation of intracellular mRNA localization, regulation of neuron apoptotic process, regulation of protein localization to nucleus, regulation of signal transduction, regulation of synaptic plasticity, response to calcium ion, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, social behavior, spermatogenesis, striatum development, synaptic vesicle transport, urea cycle, vesicle transport along microtubule, visual learning, vocal learning; MF: beta-tubulin binding, diazepam binding, dynactin binding, dynein intermediate chain binding, heat shock protein binding, identical protein binding, kinase binding, p53 binding, phosphoprotein phosphatase activity, profilin binding, protein binding, signaling receptor binding, transmembrane transporter binding; CC: Golgi apparatus, autophagosome, axon, centriole, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, dendrite, early endosome, endoplasmic reticulum, glutamatergic synapse, inclusion body, late endosome, neuronal cell body, neuronal ribonucleoprotein granule, nucleoplasm, nucleus, perinuclear region of cytoplasm, postsynaptic cytosol, presynaptic cytosol, protein-containing complex, synapse, synaptic membrane
Pathways: Huntington disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse)
UniProt: G3X9H5
Entrez ID: 15194
|
Does Knockout of Gzmc in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Gzmc
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Gzmc (granzyme C)
Type: protein-coding
Summary: This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product, expressed by activated T cells, may induce apoptosis of target cells. This gene is present in a gene cluster with other members of the granzyme subfamily on chromosome 14. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: ceramide biosynthetic process, granzyme-mediated programmed cell death signaling pathway, killing of cells of another organism, natural killer cell mediated cytotoxicity, negative regulation of translation, plasma membrane repair, positive regulation of immune response to tumor cell, protein maturation, proteolysis, proteolysis involved in protein catabolic process, pyroptotic cell death, pyroptotic inflammatory response; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytolytic granule, cytoplasm, extracellular space, lysosome
Pathways:
UniProt: P08882
Entrez ID: 14940
|
Does Knockout of Zfyve28 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Zfyve28
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Zfyve28 (zinc finger, FYVE domain containing 28)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of epidermal growth factor-activated receptor activity; MF: metal ion binding, phosphatidylinositol-3-phosphate binding, zinc ion binding; CC: cytoplasm, cytosol, early endosome membrane, endosome, membrane
Pathways:
UniProt: Q6ZPK7
Entrez ID: 231125
|
Does Knockout of Apol9b in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Apol9b
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Apol9b (apolipoprotein L 9b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, chloride transmembrane transport, cytolysis by host of symbiont cells, innate immune response, lipid transport, lipoprotein metabolic process; MF: chloride channel activity, lipid binding, molecular_function; CC: cellular_component, extracellular region, extracellular space, high-density lipoprotein particle, very-low-density lipoprotein particle
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Scavenging of heme from plasma, Vesicle-mediated transport
UniProt: A0A2R8W6I1, Q8C7I4, A0A2R8W6N5
Entrez ID: 71898
|
Does Knockout of Prune2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Prune2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Prune2 (prune homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process; CC: cytoplasm, cytosol, glutamatergic synapse, presynapse
Pathways:
UniProt: Q52KR3
Entrez ID: 353211
|
Does Knockout of Syce1l in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Syce1l
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Syce1l (synaptonemal complex central element protein 1 like)
Type: protein-coding
Summary: Predicted to be involved in synaptonemal complex assembly. Predicted to be located in intermediate filament cytoskeleton. Predicted to be active in synaptonemal complex. Is expressed in colon; metanephros; spleen; submandibular gland; and testis. Orthologous to human SYCE1L (synaptonemal complex central element protein 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, meiotic cell cycle, synaptonemal complex assembly, synaptonemal complex organization; CC: intermediate filament cytoskeleton, synaptonemal complex
Pathways:
UniProt: Q5D525
Entrez ID: 668110
|
Does Knockout of Ddb2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Ddb2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ddb2 (damage specific DNA binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, UV-damage excision repair, cellular response to UV, nucleotide-excision repair, protein autoubiquitination, protein polyubiquitination, protein ubiquitination, pyrimidine dimer repair, response to UV; MF: DNA binding, damaged DNA binding, protein-containing complex binding, ubiquitin-protein transferase activity; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, cell junction, chromosome, nucleoplasm, nucleus, protein-containing complex, site of DNA damage
Pathways: Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Dual Incision in GG-NER, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Formation of Incision Complex in GG-NER, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), Global Genome Nucleotide Excision Repair (GG-NER), Hepatitis B - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Metabolism of proteins, Neddylation, Non-small cell lung cancer - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Small cell lung cancer - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Ub-specific processing proteases, Ubiquitin mediated proteolysis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: Q99J79
Entrez ID: 107986
|
Does Knockout of Map9 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Map9
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Map9 (microtubule-associated protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, mitotic cytokinesis, mitotic spindle assembly, regulation of mitotic centrosome separation, regulation of mitotic cytokinesis, regulation of mitotic spindle organization, spindle assembly; MF: microtubule binding; CC: aster, astral microtubule, axon, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, mitotic spindle, mitotic spindle midzone, spindle, spindle midzone
Pathways:
UniProt: Q3TRR0
Entrez ID: 213582
|
Does Knockout of Eif5a2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Eif5a2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Eif5a2 (eukaryotic translation initiation factor 5A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of translational elongation, positive regulation of translational termination, translation, translational elongation; MF: RNA binding, ribosome binding, translation elongation factor activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification
UniProt: Q8BGY2
Entrez ID: 208691
|
Does Knockout of Zfp619 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Zfp619
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp619 (zinc finger protein 619)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q66JZ1, G3X9T2
Entrez ID: 70227
|
Does Knockout of Lyrm7 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Lyrm7
|
response to virus
|
Microglial Cell Line
|
Gene: Lyrm7 (LYR motif containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial respiratory chain complex III assembly, protein folding; MF: molecular_function, protein folding chaperone; CC: mitochondrial matrix, mitochondrial membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex III assembly, Metabolism, Respiratory electron transport
UniProt: Q9DA03
Entrez ID: 75530
|
Does Knockout of Mir128-2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Mir128-2
|
cell cycle progression
|
breast epithelium
|
Gene: Mir128-2 (microRNA 128-2)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: long-term synaptic potentiation, ossification
Pathways: MicroRNAs in cancer - Mus musculus (mouse)
UniProt:
Entrez ID: 723815
|
Does Knockout of Zfp608 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Zfp608
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Zfp608 (zinc finger protein 608)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of T cell differentiation in thymus, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: metal ion binding, zinc ion binding
Pathways:
UniProt: Q56A10
Entrez ID: 269023
|
Does Knockout of Fam174b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Fam174b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam174b (family with sequence similarity 174, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization; CC: Golgi apparatus, membrane, plasma membrane
Pathways:
UniProt: Q8K064
Entrez ID: 100038347
|
Does Knockout of Rusc1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Rusc1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rusc1 (RUN and SH3 domain containing 1)
Type: protein-coding
Summary: Enables actin binding activity. Predicted to be involved in protein polyubiquitination. Located in Golgi apparatus; early endosome; and microtubule cytoskeleton. Is expressed in gut; nervous system; and sensory organ. Orthologous to human RUSC1 (RUN and SH3 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: protein polyubiquitination; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, early endosome, endosome, microtubule, microtubule cytoskeleton, nucleus, postsynaptic density, synapse
Pathways:
UniProt: Q8BG26
Entrez ID: 72296
|
Does Knockout of Drd5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Drd5
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Drd5 (dopamine receptor D5)
Type: protein-coding
Summary: Enables dopamine neurotransmitter receptor activity, coupled via Gs. Acts upstream of or within several processes, including learning; long-term synaptic depression; and regulation of blood pressure. Located in brush border membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and blepharospasm. Orthologous to human DRD5 (dopamine receptor D5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled dopamine receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, associative learning, cellular response to catecholamine stimulus, long-term synaptic depression, mating behavior, negative regulation of blood pressure, negative regulation of cell migration, norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure, positive regulation of MAPK cascade, reactive oxygen species metabolic process, regulation of female receptivity, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of systemic arterial blood pressure by vasopressin, response to amphetamine, response to cocaine, sensitization, signal transduction, synaptic transmission, dopaminergic, transmission of nerve impulse, visual learning, wound healing; MF: G protein-coupled receptor activity, G-protein alpha-subunit binding, dopamine binding, dopamine neurotransmitter receptor activity, dopamine neurotransmitter receptor activity, coupled via Gs; CC: axon, brush border membrane, ciliary membrane, cilium, dendrite, dendritic spine, glutamatergic synapse, membrane, neuronal cell body, non-motile cilium, plasma membrane, plasma membrane bounded cell projection, postsynaptic density membrane, synapse
Pathways: Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Dopamine receptors, Dopaminergic synapse - Mus musculus (mouse), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q8BLD9
Entrez ID: 13492
|
Does Knockout of Pacrgl in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Pacrgl
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pacrgl (PARK2 co-regulated-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D3X5
Entrez ID: 66768
|
Does Knockout of Il2rg in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Il2rg
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Il2rg (interleukin 2 receptor, gamma chain)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
Gene Ontology: BP: cellular homeostasis, cytokine-mediated signaling pathway, immune system process, interleukin-15-mediated signaling pathway, interleukin-2-mediated signaling pathway, interleukin-4-mediated signaling pathway, interleukin-7-mediated signaling pathway, interleukin-9-mediated signaling pathway, lymphocyte differentiation, mature B cell differentiation, positive regulation of B cell differentiation, positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, positive regulation of T cell differentiation in thymus, positive regulation of gene expression, positive regulation of immunoglobulin production, positive regulation of phagocytosis, regulation of gene expression; MF: coreceptor activity, cytokine binding, cytokine receptor activity, interleukin-15 receptor activity, interleukin-2 binding; CC: cell surface, external side of plasma membrane, membrane, nucleoplasm, plasma membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin receptor SHC signaling, Interleukin-15 signaling, Interleukin-2 family signaling, Interleukin-2 signaling, Interleukin-21 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-7 signaling, Interleukin-9 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Measles - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Primary immunodeficiency - Mus musculus (mouse), RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P34902
Entrez ID: 16186
|
Does Knockout of Ddx5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ddx5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ddx5 (DEAD box helicase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, RNA splicing, alternative mRNA splicing, via spliceosome, androgen receptor signaling pathway, circadian rhythm, epithelial to mesenchymal transition, estrogen receptor signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, mRNA processing, mRNA transcription, miRNA transcription, myoblast differentiation, negative regulation of transcription by RNA polymerase II, nuclear-transcribed mRNA catabolic process, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of DNA-templated transcription, primary miRNA processing, protein import into nucleus, regulation of alternative mRNA splicing, via spliceosome, regulation of androgen receptor signaling pathway, regulation of osteoblast differentiation, regulation of skeletal muscle cell differentiation, regulation of transcription by RNA polymerase II, regulation of viral genome replication, rhythmic process; MF: ATP binding, ATP hydrolysis activity, MH2 domain binding, R-SMAD binding, RNA binding, RNA helicase activity, SMAD binding, calcium-dependent protein binding, calmodulin binding, enzyme binding, helicase activity, hydrolase activity, mRNA 3'-UTR binding, mRNA binding, nuclear androgen receptor binding, nucleic acid binding, nucleotide binding, pre-mRNA binding, primary miRNA binding, promoter-specific chromatin binding, protein binding, ribonucleoprotein complex binding, transcription coregulator activity; CC: catalytic step 2 spliceosome, cytoplasm, nuclear speck, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Proteoglycans in cancer - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: S4R1I6, Q8BTS0, B1ARB9, B1ARC0, S4R1E3
Entrez ID: 13207
|
Does Knockout of Atf7ip2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Atf7ip2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Atf7ip2 (activating transcription factor 7 interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleus, transcription regulator complex
Pathways:
UniProt: Q3UL97
Entrez ID: 75329
|
Does Knockout of Kcna4 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Kcna4
|
response to bacteria
|
renal medulla cell line
|
Gene: Kcna4 (potassium voltage-gated channel, shaker-related subfamily, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of presynaptic membrane potential, transmembrane transport; MF: delayed rectifier potassium channel activity, monoatomic ion channel activity, potassium channel activity, potassium ion binding, protein binding, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated potassium channel activity; CC: asymmetric synapse, axon, axon initial segment, cell projection, cell surface, dendritic shaft, dendritic spine, glutamatergic synapse, membrane, monoatomic ion channel complex, plasma membrane, postsynaptic membrane, presynaptic membrane, voltage-gated potassium channel complex
Pathways: Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: Q61423
Entrez ID: 16492
|
Does Knockout of P3h3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
P3h3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: P3h3 (prolyl 3-hydroxylase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen biosynthetic process, collagen metabolic process, negative regulation of cell population proliferation, peptidyl-lysine hydroxylation; MF: L-ascorbic acid binding, dioxygenase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, procollagen-proline 3-dioxygenase activity, protein binding; CC: catalytic complex, endoplasmic reticulum
Pathways: Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization
UniProt: Q8CG70
Entrez ID: 14789
|
Does Knockout of Cox19 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Cox19
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cox19 (cytochrome c oxidase assembly protein 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular copper ion homeostasis, mitochondrial cytochrome c oxidase assembly; CC: cytoplasm, cytosol, mitochondrial intermembrane space, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: Q8K0C8
Entrez ID: 68033
|
Does Knockout of 1700024G13Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
1700024G13Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: 1700024G13Rik (RIKEN cDNA 1700024G13 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3KNL4
Entrez ID: 67085
|
Does Knockout of Sfrp5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Sfrp5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Sfrp5 (secreted frizzled-related sequence protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, canonical Wnt signaling pathway, cell differentiation, convergent extension involved in axis elongation, digestive tract morphogenesis, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cell population proliferation, negative regulation of non-canonical Wnt signaling pathway, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, non-canonical Wnt signaling pathway, post-anal tail morphogenesis, regulation of establishment of planar polarity, regulation of transcription by RNA polymerase II; CC: extracellular region, extracellular space
Pathways: Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q9WU66
Entrez ID: 54612
|
Does Knockout of Ly6k in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Ly6k
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ly6k (lymphocyte antigen 6 family member K)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, flagellated sperm motility; CC: acrosomal vesicle, cell surface, cytoplasm, cytoplasmic vesicle, extracellular region, membrane, membrane raft, plasma membrane, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q9CWP4
Entrez ID: 76486
|
Does Knockout of Zfp689 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Zfp689
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfp689 (zinc finger protein 689)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal muscle cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone binding, metal ion binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8BKK5
Entrez ID: 71131
|
Does Knockout of Phf11d in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Phf11d
|
cell cycle progression
|
breast epithelium
|
Gene: Phf11d (PHD finger protein 11D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding; CC: nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: A6H5X4
Entrez ID: 219132
|
Does Knockout of Tet3 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Tet3
|
cell proliferation
|
Regulatory T cell
|
Gene: Tet3 (tet methylcytosine dioxygenase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, epigenetic programing of male pronucleus, epigenetic regulation of gene expression, positive regulation of gene expression via chromosomal CpG island demethylation, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, protein O-linked glycosylation, regulation of gene expression; MF: 2-oxoglutarate-dependent dioxygenase activity, DNA 5-methylcytosine dioxygenase activity, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, dioxygenase activity, metal ion binding, methyl-CpG binding, oxidoreductase activity, protein binding, zinc ion binding; CC: chromosome, cytoplasm, female pronucleus, male pronucleus, nucleoplasm, nucleus
Pathways:
UniProt: Q8BG87
Entrez ID: 194388
|
Does Knockout of Abhd15 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Abhd15
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Abhd15 (abhydrolase domain containing 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, lipid catabolic process, lipid metabolic process; MF: monoacylglycerol lipase activity, protein binding, short-chain carboxylesterase activity
Pathways:
UniProt: Q5F2F2
Entrez ID: 67477
|
Does Knockout of Cngb3 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Cngb3
|
cell proliferation
|
Regulatory T cell
|
Gene: Cngb3 (cyclic nucleotide gated channel beta 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, transmembrane transport, visual perception; MF: cGMP binding, cyclic nucleotide-activated monoatomic ion channel activity, intracellularly cAMP-activated cation channel activity, intracellularly cGMP-activated cation channel activity, intracellularly cyclic nucleotide-activated monoatomic cation channel activity, monoatomic ion channel activity, nucleotide binding, protein binding; CC: intracellular cyclic nucleotide activated cation channel complex, membrane, photoreceptor outer segment, plasma membrane, transmembrane transporter complex
Pathways: cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q9JJZ9
Entrez ID: 30952
|
Does Knockout of Sdhd in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Sdhd
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sdhd (succinate dehydrogenase complex, subunit D, integral membrane protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, regulation of catecholamine secretion, tricarboxylic acid cycle; MF: heme binding, metal ion binding, succinate dehydrogenase (quinone) activity, ubiquinone binding; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion, respiratory chain complex II (succinate dehydrogenase)
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II, aerobic respiration -- electron donors reaction list
UniProt: Q9CXV1
Entrez ID: 66925
|
Does Knockout of Arhgap21 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Arhgap21
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arhgap21 (Rho GTPase activating protein 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi localization, Golgi organization, establishment of Golgi localization, maintenance of Golgi location, organelle transport along microtubule, regulation of endocytosis, signal transduction; CC: Golgi apparatus, Golgi membrane, actin cytoskeleton, anchoring junction, cell junction, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, membrane, plasma membrane
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6DFV3
Entrez ID: 71435
|
Does Knockout of Cnga2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Cnga2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cnga2 (cyclic nucleotide gated channel alpha 2)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that is the main subunit of the nucleotide-gated olfactory ion channel, which plays a key role in transducing chemosensory signal resulting from hydrogen sulphide exposure. Signaling pathways mediated by this gene operate in the cilia of type B cells. Knock out of this gene affects development of the olfactory epithelium and olfactory bulb. [provided by RefSeq, Aug 2022].
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, membrane depolarization, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, sensory perception of chemical stimulus, sensory perception of smell, sodium ion transport, transmembrane transport; MF: cAMP binding, cGMP binding, calcium channel activity, calmodulin binding, identical protein binding, intracellularly cAMP-activated cation channel activity, intracellularly cGMP-activated cation channel activity, intracellularly cyclic nucleotide-activated monoatomic cation channel activity, monoatomic ion channel activity, nucleotide binding, protein-containing complex binding, voltage-gated potassium channel activity; CC: cell projection, ciliary membrane, intracellular cyclic nucleotide activated cation channel complex, membrane, non-motile cilium, non-motile cilium membrane, perikaryon, plasma membrane
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Olfactory transduction - Mus musculus (mouse), Organelle biogenesis and maintenance, VxPx cargo-targeting to cilium, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q62398
Entrez ID: 12789
|
Does Knockout of Kirrel2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Kirrel2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Kirrel2 (kirre like nephrin family adhesion molecule 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion; MF: cell adhesion molecule binding, identical protein binding, protein binding; CC: cell-cell junction, membrane, plasma membrane, slit diaphragm
Pathways: Cell-Cell communication, Nephrin family interactions
UniProt: Q7TSU7
Entrez ID: 243911
|
Does Knockout of Mis18bp1 in Lung Cancer Cell Line causally result in tumorigenicity?
| 0
| 1,089
|
Knockout
|
Mis18bp1
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Mis18bp1 (MIS18 binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, cell division, pericentric heterochromatin organization; MF: DNA binding, protein binding; CC: CENP-A recruiting complex, chromosome, chromosome, centromeric region, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, Cyclin A/B1/B2 associated events during G2/M transition, Deposition of new CENPA-containing nucleosomes at the centromere, G2/M Transition, Mitotic G2-G2/M phases, Nucleosome assembly
UniProt: Q80WQ8
Entrez ID: 217653
|
Does Knockout of Riok3 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Riok3
|
cell proliferation
|
Regulatory T cell
|
Gene: Riok3 (RIO kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to dsDNA, cellular response to dsRNA, cellular response to virus, defense response to virus, immune system process, innate immune response, maturation of SSU-rRNA, negative regulation of MDA-5 signaling pathway, negative regulation of canonical NF-kappaB signal transduction, negative regulation of protein-containing complex assembly, positive regulation of innate immune response, positive regulation of interferon-beta production, ribosome biogenesis; MF: ATP binding, caspase binding, catalytic activity, kinase activity, metal ion binding, nucleotide binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9DBU3
Entrez ID: 66878
|
Does Knockout of Toe1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,269
|
Knockout
|
Toe1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Toe1 (target of EGR1, member 1 (nuclear))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA metabolic process, snRNA 3'-end processing; MF: 3'-5'-RNA exonuclease activity, metal ion binding, nucleic acid binding, poly(A)-specific ribonuclease activity, snRNA binding, zinc ion binding; CC: Cajal body, cytoplasm, nuclear body, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9D2E2
Entrez ID: 68276
|
Does Knockout of Unc5b in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Unc5b
|
response to virus
|
Microglial Cell Line
|
Gene: Unc5b (unc-5 netrin receptor B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, anterior/posterior axon guidance, apoptotic process, axon guidance, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of neuron apoptotic process, netrin-activated signaling pathway, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, signal transduction; MF: netrin receptor activity, protein binding; CC: cytosol, membrane, membrane raft, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q8K1S3
Entrez ID: 107449
|
Does Knockout of Ccdc157 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Ccdc157
|
cell proliferation
|
Regulatory T cell
|
Gene: Ccdc157 (coiled-coil domain containing 157)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5SPX1
Entrez ID: 216516
|
Does Knockout of Lcn5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Lcn5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Lcn5 (lipocalin 5)
Type: protein-coding
Summary: This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: MF: retinoid binding, small molecule binding; CC: extracellular region, extracellular space
Pathways:
UniProt: A2AJB7
Entrez ID: 13863
|
Does Knockout of Apold1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Apold1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Apold1 (apolipoprotein L domain containing 1)
Type: protein-coding
Summary: Predicted to enable lipid binding activity. Predicted to be involved in angiogenesis and regulation of endothelial cell differentiation. Is expressed in heart ventricle. Orthologous to human APOLD1 (apolipoprotein L domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: angiogenesis, autophagosome-dependent secretion, lipid transport, lipoprotein metabolic process, regulation of endothelial cell differentiation, regulation of membrane permeability; MF: lipid binding; CC: Weibel-Palade body, cell-cell junction, extracellular region, membrane
Pathways:
UniProt: E9Q0X2
Entrez ID: 381823
|
Does Knockout of Per3 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Per3
|
phagocytosis
|
macrophage
|
Gene: Per3 (period circadian clock 3)
Type: protein-coding
Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: circadian regulation of gene expression, circadian rhythm, entrainment of circadian clock by photoperiod, negative regulation of transcription by RNA polymerase II, protein stabilization, regulation of circadian sleep/wake cycle, sleep, rhythmic process; MF: kinase binding, protein binding, transcription cis-regulatory region binding, transcription corepressor binding, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Circadian clock, Circadian entrainment - Mus musculus (mouse), Circadian rhythm - Mus musculus (mouse), Degradation of CRY and PER proteins
UniProt: O70361
Entrez ID: 18628
|
Does Knockout of Cbfb in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Cbfb
|
phagocytosis
|
macrophage
|
Gene: Cbfb (core binding factor beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell maturation, definitive hemopoiesis, lymphocyte differentiation, myeloid cell differentiation, negative regulation of CD4-positive, alpha-beta T cell differentiation, negative regulation of transcription by RNA polymerase II, ossification, osteoblast differentiation, positive regulation of CD8-positive, alpha-beta T cell differentiation, positive regulation of transcription by RNA polymerase II, protein polyubiquitination, regulation of transcription by RNA polymerase II; MF: DNA binding, protein binding, sequence-specific DNA binding, transcription coactivator activity; CC: core-binding factor complex, nucleoplasm, nucleus, protein-containing complex
Pathways: ESR-mediated signaling, Estrogen-dependent gene expression, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs), RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, RUNX1 regulates estrogen receptor mediated transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, RUNX1 regulates transcription of genes involved in BCR signaling, RUNX1 regulates transcription of genes involved in differentiation of HSCs, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells, RUNX1 regulates transcription of genes involved in interleukin signaling, RUNX2 regulates bone development, RUNX3 regulates p14-ARF, Regulation of RUNX1 Expression and Activity, Regulation of RUNX3 expression and activity, Signal Transduction, Signaling by Nuclear Receptors, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3
UniProt: Q08024
Entrez ID: 12400
|
Does Knockout of Psmf1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Psmf1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Psmf1 (proteasome (prosome, macropain) inhibitor subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process; MF: endopeptidase inhibitor activity, proteasome binding, protein heterodimerization activity, protein homodimerization activity; CC: cytoplasm, cytosol, endoplasmic reticulum, perinuclear region of cytoplasm, proteasome complex
Pathways: Proteasome - Mus musculus (mouse)
UniProt: Q8BHL8
Entrez ID: 228769
|
Does Knockout of Arl16 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Arl16
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Arl16 (ADP-ribosylation factor-like 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, GTPase activity, molecular_function, nucleotide binding
Pathways:
UniProt: Q3V3L8, B1ATY8
Entrez ID: 70317
|
Does Knockout of Bzw2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Bzw2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Bzw2 (basic leucine zipper and W2 domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of translation, regulation of translational initiation; CC: cytoplasm
Pathways:
UniProt: Q91VK1
Entrez ID: 66912
|
Does Knockout of Edrf1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Edrf1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Edrf1 (erythroid differentiation regulatory factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription; CC: cellular_component, nucleus
Pathways:
UniProt: Q6GQV7
Entrez ID: 214764
|
Does Knockout of Tlnrd1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Tlnrd1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tlnrd1 (talin rod domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: actin binding, identical protein binding, molecular_function
Pathways:
UniProt: Q9ERE8
Entrez ID: 80889
|
Does Knockout of Arhgef12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Arhgef12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Arhgef12 (Rho guanine nucleotide exchange factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho protein signal transduction, Rho-activating G protein-coupled receptor signaling pathway, intracellular signal transduction, regulation of blood pressure; MF: G protein-coupled receptor binding, GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding; CC: cytoplasm, membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), CDC42 GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, Developmental Biology, G alpha (12/13) signalling events, GPCR downstream signalling, Human cytomegalovirus infection - Mus musculus (mouse), NRAGE signals death through JNK, Nervous system development, Pathways in cancer - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tuberculosis - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cyclic AMP biosynthesis, p75 NTR receptor-mediated signalling
UniProt: Q8R4H2
Entrez ID: 69632
|
Does Knockout of B4galnt2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 167
|
Knockout
|
B4galnt2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: B4galnt2 (beta-1,4-N-acetyl-galactosaminyl transferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UDP-N-acetylgalactosamine metabolic process, UDP-N-acetylglucosamine metabolic process, carbohydrate derivative biosynthetic process, negative regulation of cell-cell adhesion, protein glycosylation, protein import, skeletal muscle fiber differentiation, skeletal muscle tissue regeneration; MF: acetylgalactosaminyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Asparagine N-linked glycosylation, Blood group systems biosynthesis, Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, Post-translational protein modification
UniProt: Q09199
Entrez ID: 14422
|
Does Knockout of Clec9a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Clec9a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Clec9a (C-type lectin domain family 9, member a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cytokine production, receptor-mediated endocytosis; CC: cell surface, membrane
Pathways:
UniProt: Q8BRU4
Entrez ID: 232414
|
Does Knockout of Abcb7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Abcb7
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Abcb7 (ATP-binding cassette, sub-family B member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular iron ion homeostasis, iron ion transmembrane transport, iron-sulfur cluster assembly, iron-sulfur cluster export from the mitochondrion, negative regulation of reactive oxygen species biosynthetic process, positive regulation of heme biosynthetic process, positive regulation of iron-sulfur cluster assembly, transmembrane transport; MF: ABC-type iron-sulfur cluster transporter activity, ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, identical protein binding, nucleotide binding, protein binding, protein homodimerization activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: ABC transporters - Mus musculus (mouse), ABC-family proteins mediated transport, Mitochondrial ABC transporters, Transport of small molecules
UniProt: Q61102
Entrez ID: 11306
|
Does Knockout of Saal1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Saal1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Saal1 (serum amyloid A-like 1)
Type: protein-coding
Summary: Predicted to be involved in positive regulation of synoviocyte proliferation. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human SAAL1 (serum amyloid A like 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: positive regulation of synoviocyte proliferation; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q9D2C2
Entrez ID: 78935
|
Does Knockout of Upk1b in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Upk1b
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Upk1b (uroplakin 1B)
Type: protein-coding
Summary: Acts upstream of or within response to bacterium. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in genitourinary system; mesothelium; pharyngo-tympanic tube; pharynx epithelium; and skin. Orthologous to human UPK1B (uroplakin 1B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: epithelial cell differentiation, response to bacterium; CC: apical plasma membrane, apical plasma membrane urothelial plaque, membrane
Pathways:
UniProt: Q9Z2C6
Entrez ID: 22268
|
Does Knockout of Tex13c3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Tex13c3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tex13c3 (TEX13 family member C3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: mRNA binding, molecular_function
Pathways:
UniProt: Q810P0
Entrez ID: 278255
|
Does Knockout of Dzank1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Dzank1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dzank1 (double zinc ribbon and ankyrin repeat domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding; CC: cell projection, cellular_component, centrosome, cytoplasm, cytoskeleton
Pathways:
UniProt: Q8C008
Entrez ID: 241688
|
Does Knockout of Kdm5a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Kdm5a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Kdm5a (lysine demethylase 5A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, circadian regulation of gene expression, facultative heterochromatin formation, male gonad development, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, rhythmic process, spermatogenesis; MF: DNA binding, chromatin DNA binding, chromatin binding, dioxygenase activity, enzyme inhibitor activity, histone H3K4 demethylase activity, histone H3K4me/H3K4me2/H3K4me3 demethylase activity, histone binding, metal ion binding, oxidoreductase activity, protein binding, transcription cis-regulatory region binding, transcription coactivator activity, zinc ion binding; CC: chromatin, nucleolus, nucleoplasm, nucleus, protein-DNA complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones
UniProt: Q3UXZ9
Entrez ID: 214899
|
Does Knockout of Dnm1l in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Dnm1l
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Dnm1l (dynamin 1-like)
Type: protein-coding
Summary: This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: calcium ion transport, cellular response to hypoxia, cellular response to lipid, endocytosis, heart contraction, intracellular distribution of mitochondria, metal ion transport, mitochondrial fission, mitochondrial fragmentation involved in apoptotic process, mitochondrial membrane fission, mitochondrion distribution, mitochondrion organization, mitocytosis, negative regulation of mitochondrial fusion, peroxisome fission, positive regulation of dendritic spine morphogenesis, positive regulation of mitochondrial fission, positive regulation of neutrophil chemotaxis, positive regulation of protein secretion, positive regulation of synaptic vesicle endocytosis, positive regulation of synaptic vesicle exocytosis, programmed cell death, protein complex oligomerization, protein localization to mitochondrion, regulation of ATP metabolic process, regulation of gene expression, regulation of mitochondrion organization, regulation of mitophagy, regulation of peroxisome organization, response to endoplasmic reticulum stress, response to flavonoid, response to hypobaric hypoxia, rhythmic process, synaptic vesicle endocytosis, synaptic vesicle recycling via endosome; MF: BH2 domain binding, GTP binding, GTP-dependent protein binding, GTPase activity, clathrin binding, hydrolase activity, identical protein binding, lipid binding, microtubule binding, nucleotide binding, protein binding, protein homodimerization activity, protein serine/threonine kinase binding, protein-containing complex binding, small GTPase binding, ubiquitin protein ligase binding; CC: Golgi apparatus, Golgi membrane, brush border, clathrin-coated pit, cytoplasm, cytoplasmic vesicle, cytosol, endomembrane system, endoplasmic reticulum, endosome, late endosome, lysosome, membrane, microtubule, microtubule cytoskeleton, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, mitochondrion-derived vesicle, perinuclear region of cytoplasm, peroxisome, plasma membrane, postsynaptic density, presynaptic endocytic zone membrane, protein-containing complex, secretory vesicle, synapse, synaptic vesicle membrane
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: Q8K1M6
Entrez ID: 74006
|
Does Knockout of Mrpl11 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Mrpl11
|
response to virus
|
Microglial Cell Line
|
Gene: Mrpl11 (mitochondrial ribosomal protein L11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: large ribosomal subunit rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CQF0
Entrez ID: 66419
|
Does Knockout of G2e3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
G2e3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: G2e3 (G2/M-phase specific E3 ubiquitin ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, blastocyst development, negative regulation of intrinsic apoptotic signaling pathway, protein polyubiquitination, protein ubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt: Q5RJY2
Entrez ID: 217558
|
Does Knockout of 4921517D22Rik in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
4921517D22Rik
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: 4921517D22Rik (RIKEN cDNA 4921517D22 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A286YDE0, Q8CET0
Entrez ID: 70900
|
Does Knockout of Ifngr2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Ifngr2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Ifngr2 (interferon gamma receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, defense response to virus, microglial cell activation, positive regulation of glutamate receptor signaling pathway, type II interferon-mediated signaling pathway, type III interferon-mediated signaling pathway; MF: cytokine receptor activity, type II interferon receptor activity; CC: membrane, plasma membrane
Pathways: Chagas disease - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), IFNG signaling activates MAPKs, Immune System, Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Regulation of IFNG signaling, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: D6RIP6, Q63953
Entrez ID: 15980
|
Does Knockout of Rbm12b2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Rbm12b2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rbm12b2 (RNA binding motif protein 12 B2)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human RBM12B (RNA binding motif protein 12B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: nucleoplasm, ribonucleoprotein complex
Pathways:
UniProt: Q66JV4
Entrez ID: 77604
|
Does Knockout of Srgap3 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Srgap3
|
cell proliferation
|
Regulatory T cell
|
Gene: Srgap3 (SLIT-ROBO Rho GTPase activating protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell migration, nervous system development, regulation of postsynapse assembly, regulation of synapse assembly, signal transduction; MF: GTPase activator activity, protein binding; CC: glutamatergic synapse, postsynapse, synapse
Pathways: Axon guidance - Mus musculus (mouse), CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q812A2
Entrez ID: 259302
|
Does Knockout of Tnfaip8l2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Tnfaip8l2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tnfaip8l2 (tumor necrosis factor, alpha-induced protein 8-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, innate immune response, negative regulation of T cell activation, negative regulation of inflammatory response, regulation of apoptotic process; CC: cytoplasm, lysosome, nucleus
Pathways: Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism
UniProt: Q9D8Y7
Entrez ID: 69769
|
Does Knockout of Adam32 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Adam32
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Adam32 (a disintegrin and metallopeptidase domain 32)
Type: protein-coding
Summary: This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene was found to be expressed predominantly in the pachytene spermatocytes, where the processed protein is localized to the sperm surface. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: binding of sperm to zona pellucida, cell adhesion, male gonad development, proteolysis; MF: metalloendopeptidase activity, metallopeptidase activity; CC: cell surface, cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q8K410
Entrez ID: 353188
|
Does Knockout of Rnh1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Rnh1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Rnh1 (ribonuclease/angiogenin inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, cytoplasmic translation, negative regulation of translation in response to stress, regulation of Arp2/3 complex-mediated actin nucleation, regulation of angiogenesis, tRNA stabilization; MF: ribonuclease inhibitor activity; CC: angiogenin-PRI complex, cytoplasm, cytosol, lamellipodium, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q91VI7
Entrez ID: 107702
|
Does Knockout of Rabl2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Rabl2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rabl2 (RAB, member RAS oncogene family-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, flagellated sperm motility, intracellular protein transport, microtubule-based movement, photoreceptor cell morphogenesis, single fertilization; MF: G protein activity, GTP binding, GTPase activity, nucleotide binding, protein binding; CC: centriole, ciliary basal body, cilium, cytoplasm, endomembrane system, intraciliary transport particle B, pericentriolar material, sperm midpiece
Pathways:
UniProt: E9Q9D5
Entrez ID: 68708
|
Does Knockout of Supt7l in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Supt7l
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Supt7l (SPT7-like, STAGA complex gamma subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of protein location in nucleus, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing; MF: protein heterodimerization activity, transcription coactivator activity; CC: SAGA complex, nucleoplasm, nucleus
Pathways:
UniProt: Q9CZV5
Entrez ID: 72195
|
Does Knockout of Lrwd1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Lrwd1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Lrwd1 (leucine-rich repeats and WD repeat domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, chromatin organization, establishment of protein localization to chromatin; MF: chromatin binding, histone H3K27me3 reader activity, methyl-CpG binding; CC: centrosome, chromosome, chromosome, centromeric region, chromosome, telomeric region, cytoplasm, cytoskeleton, kinetochore, nuclear origin of replication recognition complex, nucleolus, nucleoplasm, nucleus, pericentric heterochromatin
Pathways:
UniProt: Q8BUI3
Entrez ID: 71735
|
Does Knockout of Atp6v1g2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Atp6v1g2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Atp6v1g2 (ATPase, H+ transporting, lysosomal V1 subunit G2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: ATP hydrolysis activity, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: clathrin-coated vesicle membrane, cytoplasmic vesicle, extrinsic component of synaptic vesicle membrane, melanosome, membrane, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9WTT4
Entrez ID: 66237
|
Does Knockout of Ssna1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Ssna1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ssna1 (SS nuclear autoantigen 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon arborization, axon extension, axonogenesis, cell division, intraciliary transport, microtubule cytoskeleton organization, microtubule nucleation, nervous system development, receptor clustering, smoothened signaling pathway; MF: identical protein binding, microtubule binding; CC: axon, axoneme, cell projection, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, midbody, motile cilium, nucleus, plasma membrane, supramolecular fiber
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9JJ94
Entrez ID: 68475
|
Does Knockout of Hyou1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Hyou1
|
phagocytosis
|
macrophage
|
Gene: Hyou1 (hypoxia up-regulated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, endoplasmic reticulum to Golgi vesicle-mediated transport, negative regulation of apoptotic process, negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway, protein folding, regulation of cellular response to stress, response to endoplasmic reticulum stress, response to hypoxia, response to ischemia, response to stress; MF: ATP binding, ATP-dependent protein folding chaperone, adenyl-nucleotide exchange factor activity, nucleotide binding; CC: endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, extracellular region, mitochondrion, smooth endoplasmic reticulum
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9JKR6
Entrez ID: 12282
|
Does Knockout of Elp3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,565
|
Knockout
|
Elp3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Elp3 (elongator acetyltransferase complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central nervous system development, nervous system development, neuron migration, positive regulation of cell migration, regulation of transcription by RNA polymerase II, tRNA processing, tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation, tRNA wobble uridine modification; MF: 4 iron, 4 sulfur cluster binding, RNA binding, acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, catalytic activity, iron-sulfur cluster binding, metal ion binding, phosphorylase kinase regulator activity, tRNA binding, tRNA uridine(34) acetyltransferase activity, transferase activity; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleolus, nucleus
Pathways:
UniProt: Q9CZX0
Entrez ID: 74195
|
Does Knockout of Pop5 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Pop5
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Pop5 (processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae))
Type: protein-coding
Summary: Enables ribonuclease P activity. Acts upstream of or within tRNA processing. Part of nucleolar ribonuclease P complex. Is expressed in Meckel's cartilage and skeleton. Orthologous to human POP5 (POP5 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: ribonuclease MRP activity, ribonuclease P RNA binding, ribonuclease P activity; CC: multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonuclease MRP complex, ribonuclease P complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9DB28
Entrez ID: 117109
|
Does Knockout of Krtap21-1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Krtap21-1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Krtap21-1 (keratin associated protein 21-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation, developmental growth, hair cycle process, hair follicle development, pigment accumulation in tissues, post-embryonic camera-type eye development, regulation of cell cycle, signal transduction, skin development; CC: cellular_component, intermediate filament
Pathways:
UniProt: B9EK12
Entrez ID: 170656
|
Does Knockout of Nkapl in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Nkapl
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Nkapl (NFKB activating protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, regulation of gene expression, spermatogenesis; MF: chromatin binding, molecular_function; CC: nucleus
Pathways:
UniProt: Q5SZT7
Entrez ID: 66707
|
Does Knockout of Rbm12b1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Rbm12b1
|
cell cycle progression
|
breast epithelium
|
Gene: Rbm12b1 (RNA binding motif protein 12 B1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in central nervous system and sensory organ. Orthologous to human RBM12B (RNA binding motif protein 12B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: nucleoplasm, ribonucleoprotein complex
Pathways:
UniProt: Q80YR9
Entrez ID: 72397
|
Does Knockout of Map3k19 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Map3k19
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Map3k19 (mitogen-activated protein kinase kinase kinase 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, signal transduction; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: E9Q3S4
Entrez ID: 22625
|
Does Knockout of Tekt4 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Tekt4
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Tekt4 (tektin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, cilium movement involved in cell motility, flagellated sperm motility, regulation of brood size; CC: axonemal A tubule inner sheath, axonemal microtubule, cell projection, cilium, cytoplasm, cytoskeleton, microtubule cytoskeleton, motile cilium, sperm flagellum, sperm midpiece, sperm principal piece
Pathways:
UniProt: Q149S1
Entrez ID: 71840
|
Does Knockout of Rpl34 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,263
|
Knockout
|
Rpl34
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rpl34 (ribosomal protein L34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, mitochondrion, nucleolus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D1R9
Entrez ID: 68436
|
Does Knockout of Mettl8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Mettl8
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mettl8 (methyltransferase 8, methylcytidine)
Type: protein-coding
Summary: This locus encodes a member of the methyltransferase family, and is involved in chromatin remodeling. Transcripts from this locus can be induced or inhibited by cell stretch and affect cell differentiation in the myogenic or adipogenic pathways. Multiple transcript variants encoding different isoforms have been found for this gene. Additional splice variants have been described in the literature but they meet nonsense-mediated decay (NMD) criteria and are likely to be degraded as soon as they are transcribed. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin remodeling, fat cell differentiation, mRNA metabolic process, methylation, mitochondrial tRNA modification, positive regulation of mitochondrial translation, skeletal muscle tissue development, tRNA C3-cytosine methylation, tRNA processing; MF: RNA methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, histone acetyltransferase activity, mRNA methyltransferase activity, methyltransferase activity, tRNA (cytidine-3-)-methyltransferase activity, transferase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion, nucleus
Pathways:
UniProt: A2AUU0
Entrez ID: 228019
|
Does Knockout of Btnl1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Btnl1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Btnl1 (butyrophilin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, extrathymic T cell selection, regulation of cytokine production; CC: cell surface, external side of plasma membrane, membrane
Pathways:
UniProt: Q7TST0
Entrez ID: 100038862
|
Does Knockout of Mir7032 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Mir7032
|
cell cycle progression
|
breast epithelium
|
Gene: Mir7032 (microRNA 7032)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465625
|
Does Knockout of Mtmr1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Mtmr1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mtmr1 (myotubularin related protein 1)
Type: protein-coding
Summary: Enables phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and regulation of phosphatidylinositol dephosphorylation. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human MTMR1 (myotubularin related protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: lipid metabolic process, phosphatidylinositol dephosphorylation, protein destabilization, regulation of phosphatidylinositol dephosphorylation; MF: hydrolase activity, phosphatidylinositol phosphate phosphatase activity, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity, protein homodimerization activity; CC: cytoplasm, membrane, plasma membrane
Pathways: Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, RHO GTPase cycle, RHOF GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Synthesis of PIPs at the plasma membrane
UniProt: Q9Z2C4
Entrez ID: 53332
|
Does Knockout of Vmn1r226 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Vmn1r226
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Vmn1r226 (vomeronasal 1 receptor 226)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R2A8
Entrez ID: 171225
|
Does Knockout of H2-M5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
H2-M5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: H2-M5 (histocompatibility 2, M region locus 5)
Type: protein-coding
Summary: Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in brain and thymus. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, antigen processing and presentation of peptide antigen via MHC class I, immune response, immune system process, positive regulation of T cell mediated cytotoxicity; MF: peptide antigen binding, signaling receptor binding; CC: MHC class I protein complex, external side of plasma membrane, extracellular space, lumenal side of endoplasmic reticulum membrane, membrane, phagocytic vesicle membrane
Pathways: Adaptive Immune System, Allograft rejection - Mus musculus (mouse), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, DAP12 interactions, ER-Phagosome pathway, Endocytosis - Mus musculus (mouse), Endosomal/Vacuolar pathway, Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Neutrophil degranulation, Phagosome - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: H3BJA9, A7VMS3, H3BK58, F6VXI7
Entrez ID: 240095
|
Does Knockout of Dna2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Dna2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dna2 (DNA replication helicase/nuclease 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, DNA replication, DNA replication checkpoint signaling, DNA replication, Okazaki fragment processing, DNA replication, removal of RNA primer, base-excision repair, mitochondrial DNA repair, mitochondrial DNA replication, mitotic telomere maintenance via semi-conservative replication, positive regulation of DNA replication, replication fork reversal, telomere maintenance, telomere maintenance via semi-conservative replication; MF: 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, 5'-flap endonuclease activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, RNA binding, catalytic activity, deoxyribonuclease (pyrimidine dimer) activity, endonuclease activity, helicase activity, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nuclease activity, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: chromosome, telomeric region, cytoplasm, gamma DNA polymerase complex, mitochondrial nucleoid, mitochondrion, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Extension of Telomeres, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Lagging Strand Synthesis, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Transcriptional Regulation by TP53
UniProt: Q6ZQJ5
Entrez ID: 327762
|
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