prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Vmn1r149 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 1 | 345 | Knockout | Vmn1r149 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Vmn1r149 (vomeronasal 1 receptor 149)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled recepto... |
Does Knockout of Ranbp2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Ranbp2 | cell proliferation | Melanoma Cell Line | Gene: Ranbp2 (RAN binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, centrosome localization, cytoplasmic pattern recognition receptor signaling pathway, intracellular glucose homeostasis, mRNA transport, negative r... |
Does Knockout of 4930571K23Rik in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | 4930571K23Rik | protein/peptide distribution | myoblast cell line | Gene: 4930571K23Rik (RIKEN cDNA 4930571K23 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 75861 |
Does Knockout of Fam184a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Fam184a | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Fam184a (family with sequence similarity 184, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: P-body, centriolar satellite, ciliary basal body, cytosol
Pathways:
UniProt: E9QAL2, E9PW83, F6R487, A0A1W2P7N4, A0A1W2P6N4, F6ZCT9, F6RSY8, A0... |
Does Knockout of Brca2 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Brca2 | phagocytosis | macrophage | Gene: Brca2 (breast cancer 2, early onset)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA recombination, DNA repair, brain development, cell population proliferation, cellular respon... |
Does Knockout of Trappc1 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Trappc1 | cell proliferation | Regulatory T cell | Gene: Trappc1 (trafficking protein particle complex 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TR... |
Does Knockout of Otx1 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Otx1 | cell proliferation | Regulatory T cell | Gene: Otx1 (orthodenticle homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the bicoid subfamily of the paired homeobox transcription factor family. The encoded protein is critical to the maintenance and regionalization of the forebrain and midbrain during development. It may also ... |
Does Knockout of Cox6a1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,176 | Knockout | Cox6a1 | cell proliferation | Colonic Cancer Cell Line | Gene: Cox6a1 (cytochrome c oxidase subunit 6A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; MF: enzyme regulator activity, oxidoreductase activity; CC: membrane, mitochondrial inner m... |
Does Knockout of Anks4b in Immortal mouse chromaffin cells causally result in cell viability? | 1 | 2,469 | Knockout | Anks4b | cell viability | Immortal mouse chromaffin cells | Gene: Anks4b (ankyrin repeat and sterile alpha motif domain containing 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brush border assembly, cell differentiation, protein localization to microvillus, protein-containing complex assembly, response to endoplasmic reticu... |
Does Knockout of Mfsd1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Mfsd1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Mfsd1 (major facilitator superfamily domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dipeptide transmembrane transport, dipeptide transmembrane transport from lysosomal lumen to cytosol, protein localization to lysosome, protein stabilization, t... |
Does Knockout of Epha10 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Epha10 | protein/peptide distribution | Microglial Cell Line | Gene: Epha10 (Eph receptor A10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell surface receptor protein tyrosine kinase signaling pathway, ephrin receptor signaling pathway; MF: ATP binding, ephrin receptor activity, kinase activity, nucleotide bindin... |
Does Knockout of Htt in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Htt | protein/peptide distribution | myoblast cell line | Gene: Htt (huntingtin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled dopamine receptor signaling pathway, Golgi organization, anatomical structure morphogenesis, anterior/posterior pattern specification, associative learning, axo-dendritic transport, b... |
Does Knockout of Gzmc in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Gzmc | response to chemicals | Pancreatic Cancer Cell Line | Gene: Gzmc (granzyme C)
Type: protein-coding
Summary: This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product, expressed by activated T cells, may induce apoptosis of target cells... |
Does Knockout of Zfyve28 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Zfyve28 | cell proliferation | Embryonic Stem Cell Line | Gene: Zfyve28 (zinc finger, FYVE domain containing 28)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in cytosol. Predicte... |
Does Knockout of Apol9b in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Apol9b | protein/peptide accumulation | Microglial Cell Line | Gene: Apol9b (apolipoprotein L 9b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, chloride transmembrane transport, cytolysis by host of symbiont cells, innate immune response, lipid transport, lipoprotein metabolic process; MF: chloride channel activ... |
Does Knockout of Prune2 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Prune2 | protein/peptide accumulation | Embryonic Cell Line | Gene: Prune2 (prune homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process; CC: cytoplasm, cytosol, glutamatergic synapse, presynapse
Pathways:
UniProt: Q52KR3
Entrez ID: 353211 |
Does Knockout of Syce1l in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Syce1l | cell proliferation | Colonic Cancer Cell Line | Gene: Syce1l (synaptonemal complex central element protein 1 like)
Type: protein-coding
Summary: Predicted to be involved in synaptonemal complex assembly. Predicted to be located in intermediate filament cytoskeleton. Predicted to be active in synaptonemal complex. Is expressed in colon; metanephros; s... |
Does Knockout of Ddb2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Ddb2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Ddb2 (damage specific DNA binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, UV-damage excision repair, cellular response to UV, nucleotide-excision repair, protein autoubiquitination, protein polyubiquitination, prot... |
Does Knockout of Map9 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Map9 | cell proliferation | Melanoma Cell Line | Gene: Map9 (microtubule-associated protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, mitotic cytokinesis, mitotic spindle assembly, regulation of mitotic centrosome separation, regulation of mitotic cytokinesis, regulation of mitotic spindle organi... |
Does Knockout of Eif5a2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Eif5a2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Eif5a2 (eukaryotic translation initiation factor 5A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of translational elongation, positive regulation of translational termination, translation, translational elongation; MF: RNA binding, ribosome ... |
Does Knockout of Zfp619 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Zfp619 | cell proliferation | Melanoma Cell Line | Gene: Zfp619 (zinc finger protein 619)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion ... |
Does Knockout of Lyrm7 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Lyrm7 | response to virus | Microglial Cell Line | Gene: Lyrm7 (LYR motif containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial respiratory chain complex III assembly, protein folding; MF: molecular_function, protein folding chaperone; CC: mitochondrial matrix, mitochondrial mem... |
Does Knockout of Mir128-2 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Mir128-2 | cell cycle progression | breast epithelium | Gene: Mir128-2 (microRNA 128-2)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymera... |
Does Knockout of Zfp608 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Zfp608 | response to chemicals | pro-B-lymphocyte | Gene: Zfp608 (zinc finger protein 608)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of T cell differentiation in thymus, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: metal ion bindi... |
Does Knockout of Fam174b in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Fam174b | cell proliferation | Mouse kidney carcinoma cell | Gene: Fam174b (family with sequence similarity 174, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization; CC: Golgi apparatus, membrane, plasma membrane
Pathways:
UniProt: Q8K064
Entrez ID: 100038347 |
Does Knockout of Rusc1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Rusc1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Rusc1 (RUN and SH3 domain containing 1)
Type: protein-coding
Summary: Enables actin binding activity. Predicted to be involved in protein polyubiquitination. Located in Golgi apparatus; early endosome; and microtubule cytoskeleton. Is expressed in gut; nervous system; and sensory organ. Orthologou... |
Does Knockout of Drd5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Drd5 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Drd5 (dopamine receptor D5)
Type: protein-coding
Summary: Enables dopamine neurotransmitter receptor activity, coupled via Gs. Acts upstream of or within several processes, including learning; long-term synaptic depression; and regulation of blood pressure. Located in brush border membrane. Is exp... |
Does Knockout of Pacrgl in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Pacrgl | cell proliferation | Colonic Cancer Cell Line | Gene: Pacrgl (PARK2 co-regulated-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D3X5
Entrez ID: 66768 |
Does Knockout of Il2rg in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Il2rg | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Il2rg (interleukin 2 receptor, gamma chain)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through thi... |
Does Knockout of Ddx5 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Ddx5 | protein/peptide accumulation | Embryonic Cell Line | Gene: Ddx5 (DEAD box helicase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, RNA splicing, alternative mRNA splicing, via spliceosome, androgen receptor signaling pathway, circadian rhythm, epithelial to mesenchymal transition, estrogen receptor... |
Does Knockout of Atf7ip2 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Atf7ip2 | response to virus | Neuroblastoma Cell Line | Gene: Atf7ip2 (activating transcription factor 7 interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleus, transcription regulator complex
Pathways:
UniProt: Q3UL97
Entrez ID: 75329 |
Does Knockout of Kcna4 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Kcna4 | response to bacteria | renal medulla cell line | Gene: Kcna4 (potassium voltage-gated channel, shaker-related subfamily, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion trans... |
Does Knockout of P3h3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 2,173 | Knockout | P3h3 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: P3h3 (prolyl 3-hydroxylase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen biosynthetic process, collagen metabolic process, negative regulation of cell population proliferation, peptidyl-lysine hydroxylation; MF: L-ascorbic acid binding, dioxygenase act... |
Does Knockout of Cox19 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,682 | Knockout | Cox19 | protein/peptide distribution | myoblast cell line | Gene: Cox19 (cytochrome c oxidase assembly protein 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular copper ion homeostasis, mitochondrial cytochrome c oxidase assembly; CC: cytoplasm, cytosol, mitochondrial intermembrane space, mitochondrion
Path... |
Does Knockout of 1700024G13Rik in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | 1700024G13Rik | cell proliferation | Mouse kidney carcinoma cell | Gene: 1700024G13Rik (RIKEN cDNA 1700024G13 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3KNL4
Entrez ID: 67085 |
Does Knockout of Sfrp5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Sfrp5 | cell proliferation | Colonic Cancer Cell Line | Gene: Sfrp5 (secreted frizzled-related sequence protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, canonical Wnt signaling pathway, cell differentiation, convergent extension involved in axis elongation, digestive tract morphogenesis, negati... |
Does Knockout of Ly6k in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Ly6k | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Ly6k (lymphocyte antigen 6 family member K)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, flagellated sperm motility; CC: acrosomal vesicle, cell surface, cytoplasm, cytoplasmic vesicle, extracellular region, membrane, membrane ... |
Does Knockout of Zfp689 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Zfp689 | cell proliferation | Colonic Cancer Cell Line | Gene: Zfp689 (zinc finger protein 689)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal muscle cell differentiation; MF: DNA binding, DNA-binding transcription factor acti... |
Does Knockout of Phf11d in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Phf11d | cell cycle progression | breast epithelium | Gene: Phf11d (PHD finger protein 11D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding; CC: nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: A6H5X4
Entrez ID: 219132 |
Does Knockout of Tet3 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Tet3 | cell proliferation | Regulatory T cell | Gene: Tet3 (tet methylcytosine dioxygenase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, epigenetic programing of male pronucleus, epigenetic regulation of gene expression, positive regulation of gene expression via chromosomal CpG island deme... |
Does Knockout of Abhd15 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Abhd15 | protein/peptide distribution | myoblast cell line | Gene: Abhd15 (abhydrolase domain containing 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, lipid catabolic process, lipid metabolic process; MF: monoacylglycerol lipase activity, protein binding, short-chain carboxylesterase activity
... |
Does Knockout of Cngb3 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Cngb3 | cell proliferation | Regulatory T cell | Gene: Cngb3 (cyclic nucleotide gated channel beta 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, transmembrane transport, visual p... |
Does Knockout of Sdhd in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Sdhd | cell proliferation | Embryonic Stem Cell Line | Gene: Sdhd (succinate dehydrogenase complex, subunit D, integral membrane protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthes... |
Does Knockout of Arhgap21 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Arhgap21 | protein/peptide distribution | myoblast cell line | Gene: Arhgap21 (Rho GTPase activating protein 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi localization, Golgi organization, establishment of Golgi localization, maintenance of Golgi location, organelle transport along microtubule, regulation of endocytosis, ... |
Does Knockout of Cnga2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Cnga2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Cnga2 (cyclic nucleotide gated channel alpha 2)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that is the main subunit of the nucleotide-gated olfactory ion channel, which plays a key role in transducing chemosensory signal resulting from hydrogen sulphide exposure. Signa... |
Does Knockout of Kirrel2 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Kirrel2 | protein/peptide accumulation | Regulatory T cell | Gene: Kirrel2 (kirre like nephrin family adhesion molecule 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion; MF: cell adhesion molecule binding, identical protein binding, protein binding; CC: cell-cell junction, membrane, plasma membra... |
Does Knockout of Mis18bp1 in Lung Cancer Cell Line causally result in tumorigenicity? | 0 | 1,089 | Knockout | Mis18bp1 | tumorigenicity | Lung Cancer Cell Line | Gene: Mis18bp1 (MIS18 binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, cell division, pericentric heterochromatin organization; MF: DNA binding, protein binding; CC: CENP-A recruiting complex, chromosome, chromosome,... |
Does Knockout of Riok3 in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Riok3 | cell proliferation | Regulatory T cell | Gene: Riok3 (RIO kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to dsDNA, cellular response to dsRNA, cellular response to virus, defense response to virus, immune system process, innate immune response, maturation of SSU-rRNA, negative regula... |
Does Knockout of Toe1 in Melanoma Cell Line causally result in cell proliferation? | 1 | 1,269 | Knockout | Toe1 | cell proliferation | Melanoma Cell Line | Gene: Toe1 (target of EGR1, member 1 (nuclear))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA metabolic process, snRNA 3'-end processing; MF: 3'-5'-RNA exonuclease activity, metal ion binding, nucleic acid binding, poly(A)-specific ribonuclease activity, snRNA bindi... |
Does Knockout of Unc5b in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Unc5b | response to virus | Microglial Cell Line | Gene: Unc5b (unc-5 netrin receptor B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, anterior/posterior axon guidance, apoptotic process, axon guidance, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation o... |
Does Knockout of Ccdc157 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Ccdc157 | cell proliferation | Regulatory T cell | Gene: Ccdc157 (coiled-coil domain containing 157)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5SPX1
Entrez ID: 216516 |
Does Knockout of Lcn5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Lcn5 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Lcn5 (lipocalin 5)
Type: protein-coding
Summary: This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding mul... |
Does Knockout of Apold1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Apold1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Apold1 (apolipoprotein L domain containing 1)
Type: protein-coding
Summary: Predicted to enable lipid binding activity. Predicted to be involved in angiogenesis and regulation of endothelial cell differentiation. Is expressed in heart ventricle. Orthologous to human APOLD1 (apolipoprotein L domain... |
Does Knockout of Per3 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Per3 | phagocytosis | macrophage | Gene: Per3 (period circadian clock 3)
Type: protein-coding
Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian ... |
Does Knockout of Cbfb in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Cbfb | phagocytosis | macrophage | Gene: Cbfb (core binding factor beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell maturation, definitive hemopoiesis, lymphocyte differentiation, myeloid cell differentiation, negative regulation of CD4-positive, alpha-beta T cell differentiation, negative regula... |
Does Knockout of Psmf1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Psmf1 | cell proliferation | Colonic Cancer Cell Line | Gene: Psmf1 (proteasome (prosome, macropain) inhibitor subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein c... |
Does Knockout of Arl16 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Arl16 | cell proliferation | Mouse kidney carcinoma cell | Gene: Arl16 (ADP-ribosylation factor-like 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, GTPase activity, molecular_function, nucleotide binding
Pathways:
UniProt: Q3V3L8, B1ATY8
Entrez ID: 70317 |
Does Knockout of Bzw2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Bzw2 | cell proliferation | Melanoma Cell Line | Gene: Bzw2 (basic leucine zipper and W2 domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of translation, regulation of translational initiation; CC: cytoplasm
Pathways:
UniProt: Q91VK1
Entrez ID: 66912 |
Does Knockout of Edrf1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Edrf1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Edrf1 (erythroid differentiation regulatory factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription; CC: cellular_component, nucleus
Pathways:
UniProt: Q6GQV7
Entrez ID: 214764 |
Does Knockout of Tlnrd1 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Tlnrd1 | cell proliferation | Embryonic Stem Cell Line | Gene: Tlnrd1 (talin rod domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: actin binding, identical protein binding, molecular_function
Pathways:
UniProt: Q9ERE8
Entrez ID: 80889 |
Does Knockout of Arhgef12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 163 | Knockout | Arhgef12 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Arhgef12 (Rho guanine nucleotide exchange factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho protein signal transduction, Rho-activating G protein-coupled receptor signaling pathway, intracellular signal tran... |
Does Knockout of B4galnt2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 167 | Knockout | B4galnt2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: B4galnt2 (beta-1,4-N-acetyl-galactosaminyl transferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UDP-N-acetylgalactosamine metabolic process, UDP-N-acetylglucosamine metabolic process, carbohydrate derivative biosynthetic process, negative regulation of cel... |
Does Knockout of Clec9a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Clec9a | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Clec9a (C-type lectin domain family 9, member a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cytokine production, receptor-mediated endocytosis; CC: cell surface, membrane
Pathways:
UniProt: Q8BRU4
Entrez ID: 232... |
Does Knockout of Abcb7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 2,173 | Knockout | Abcb7 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Abcb7 (ATP-binding cassette, sub-family B member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular iron ion homeostasis, iron ion transmembrane transport, iron-sulfur cluster assembly, iron-sulfur cluster export from the mitochondrion, negative regula... |
Does Knockout of Saal1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Saal1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Saal1 (serum amyloid A-like 1)
Type: protein-coding
Summary: Predicted to be involved in positive regulation of synoviocyte proliferation. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human SAAL1 (serum amyloid A like 1). [provided by Alliance of Genome... |
Does Knockout of Upk1b in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Upk1b | protein/peptide distribution | Microglial Cell Line | Gene: Upk1b (uroplakin 1B)
Type: protein-coding
Summary: Acts upstream of or within response to bacterium. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in genitourinary system; mesothelium; pharyngo-tympanic tube; pharynx epithelium; and skin. Or... |
Does Knockout of Tex13c3 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Tex13c3 | cell proliferation | Colonic Cancer Cell Line | Gene: Tex13c3 (TEX13 family member C3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: mRNA binding, molecular_function
Pathways:
UniProt: Q810P0
Entrez ID: 278255 |
Does Knockout of Dzank1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Dzank1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Dzank1 (double zinc ribbon and ankyrin repeat domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding; CC: cell projection, cellular_component, centrosome, cytoplasm, cytoskeleton
Pathways:
... |
Does Knockout of Kdm5a in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Kdm5a | cell proliferation | Melanoma Cell Line | Gene: Kdm5a (lysine demethylase 5A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, circadian regulation of gene expression, facultative heterochromatin formation, male gonad development, negative regulation of transcription b... |
Does Knockout of Dnm1l in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Dnm1l | protein/peptide accumulation | Melanoma Cell Line | Gene: Dnm1l (dynamin 1-like)
Type: protein-coding
Summary: This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splici... |
Does Knockout of Mrpl11 in Microglial Cell Line causally result in response to virus? | 0 | 1,438 | Knockout | Mrpl11 | response to virus | Microglial Cell Line | Gene: Mrpl11 (mitochondrial ribosomal protein L11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: large ribosomal subunit rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large r... |
Does Knockout of G2e3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | G2e3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: G2e3 (G2/M-phase specific E3 ubiquitin ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, blastocyst development, negative regulation of intrinsic apoptotic signaling pathway, protein polyubiquitination, protein ubiquitination; MF: metal ion ... |
Does Knockout of 4921517D22Rik in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | 4921517D22Rik | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: 4921517D22Rik (RIKEN cDNA 4921517D22 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A286YDE0, Q8CET0
Entrez ID: 70900 |
Does Knockout of Ifngr2 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,180 | Knockout | Ifngr2 | tumorigenicity | Colonic Cancer Cell Line | Gene: Ifngr2 (interferon gamma receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, defense response to virus, microglial cell activation, positive regulation of glutamate receptor signaling pathway, type II interferon-mediated ... |
Does Knockout of Rbm12b2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Rbm12b2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Rbm12b2 (RNA binding motif protein 12 B2)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human RBM12B (RNA bindi... |
Does Knockout of Srgap3 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Srgap3 | cell proliferation | Regulatory T cell | Gene: Srgap3 (SLIT-ROBO Rho GTPase activating protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell migration, nervous system development, regulation of postsynapse assembly, regulation of synapse assembly, signal transduction; MF: GTPase ... |
Does Knockout of Tnfaip8l2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Tnfaip8l2 | cell proliferation | Melanoma Cell Line | Gene: Tnfaip8l2 (tumor necrosis factor, alpha-induced protein 8-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, innate immune response, negative regulation of T cell activation, negative regulation of inflammatory response, regulation of apo... |
Does Knockout of Adam32 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Adam32 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Adam32 (a disintegrin and metallopeptidase domain 32)
Type: protein-coding
Summary: This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The ... |
Does Knockout of Rnh1 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Rnh1 | protein/peptide accumulation | Regulatory T cell | Gene: Rnh1 (ribonuclease/angiogenin inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, cytoplasmic translation, negative regulation of translation in response to stress, regulation of Arp2/3 complex-mediated actin nucleation, regulation of angiog... |
Does Knockout of Rabl2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Rabl2 | cell proliferation | Melanoma Cell Line | Gene: Rabl2 (RAB, member RAS oncogene family-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, flagellated sperm motility, intracellular protein transport, microtubule-based movement, photoreceptor cell morphogenesis, single fertilization; MF: G pro... |
Does Knockout of Supt7l in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Supt7l | protein/peptide accumulation | Embryonic Cell Line | Gene: Supt7l (SPT7-like, STAGA complex gamma subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of protein location in nucleus, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing; MF: protein heterodi... |
Does Knockout of Lrwd1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Lrwd1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Lrwd1 (leucine-rich repeats and WD repeat domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, chromatin organization, establishment of protein localization to chromatin; MF: chromatin binding, histone H3K27me3 reader activity, methy... |
Does Knockout of Atp6v1g2 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Atp6v1g2 | cell proliferation | Embryonic Stem Cell Line | Gene: Atp6v1g2 (ATPase, H+ transporting, lysosomal V1 subunit G2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification; MF: ATP hydrolysis activity, protein binding, proton-transport... |
Does Knockout of Ssna1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Ssna1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Ssna1 (SS nuclear autoantigen 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon arborization, axon extension, axonogenesis, cell division, intraciliary transport, microtubule cytoskeleton organization, microtubule nucleation, nervous system development, recept... |
Does Knockout of Hyou1 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Hyou1 | phagocytosis | macrophage | Gene: Hyou1 (hypoxia up-regulated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, endoplasmic reticulum to Golgi vesicle-mediated transport, negative regulation of apoptotic process, negative regulation of endoplasmic reticulum stress-indu... |
Does Knockout of Elp3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,565 | Knockout | Elp3 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Elp3 (elongator acetyltransferase complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central nervous system development, nervous system development, neuron migration, positive regulation of cell migration, regulation of transcription by RNA polymeras... |
Does Knockout of Pop5 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Pop5 | protein/peptide distribution | Microglial Cell Line | Gene: Pop5 (processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae))
Type: protein-coding
Summary: Enables ribonuclease P activity. Acts upstream of or within tRNA processing. Part of nucleolar ribonuclease P complex. Is expressed in Meckel's cartilage and skeleton. Orthologous to human POP... |
Does Knockout of Krtap21-1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Krtap21-1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Krtap21-1 (keratin associated protein 21-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation, developmental growth, hair cycle process, hair follicle development, pigment accumulation in tissues, post-embryonic camera-type eye developmen... |
Does Knockout of Nkapl in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Nkapl | response to virus | Embryonic Fibroblast Cell Line | Gene: Nkapl (NFKB activating protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, regulation of gene expression, spermatogenesis; MF: chromatin binding, molecular_function; CC: nucleus
Pathways:
UniProt: Q5SZT7
Ent... |
Does Knockout of Rbm12b1 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Rbm12b1 | cell cycle progression | breast epithelium | Gene: Rbm12b1 (RNA binding motif protein 12 B1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in central nervous system... |
Does Knockout of Map3k19 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Map3k19 | cell proliferation | Mouse kidney carcinoma cell | Gene: Map3k19 (mitogen-activated protein kinase kinase kinase 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, signal transduction; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase a... |
Does Knockout of Tekt4 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Tekt4 | protein/peptide distribution | Microglial Cell Line | Gene: Tekt4 (tektin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, cilium movement involved in cell motility, flagellated sperm motility, regulation of brood size; CC: axonemal A tubule inner sheath, axonemal microtubule,... |
Does Knockout of Rpl34 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,263 | Knockout | Rpl34 | cell proliferation | Colonic Cancer Cell Line | Gene: Rpl34 (ribosomal protein L34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subun... |
Does Knockout of Mettl8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Mettl8 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Mettl8 (methyltransferase 8, methylcytidine)
Type: protein-coding
Summary: This locus encodes a member of the methyltransferase family, and is involved in chromatin remodeling. Transcripts from this locus can be induced or inhibited by cell stretch and affect cell differentiation in the myogenic o... |
Does Knockout of Btnl1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Btnl1 | protein/peptide distribution | myoblast cell line | Gene: Btnl1 (butyrophilin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, extrathymic T cell selection, regulation of cytokine production; CC: cell surface, external side of plasma membrane, membrane
Pathways:
... |
Does Knockout of Mir7032 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Mir7032 | cell cycle progression | breast epithelium | Gene: Mir7032 (microRNA 7032)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of Mtmr1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Mtmr1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Mtmr1 (myotubularin related protein 1)
Type: protein-coding
Summary: Enables phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and regulation of phosphatidylinositol dephosphorylation. Located in cytoplasm and plasma membrane.... |
Does Knockout of Vmn1r226 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Vmn1r226 | protein/peptide distribution | Microglial Cell Line | Gene: Vmn1r226 (vomeronasal 1 receptor 226)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromon... |
Does Knockout of H2-M5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | H2-M5 | cell proliferation | Colonic Cancer Cell Line | Gene: H2-M5 (histocompatibility 2, M region locus 5)
Type: protein-coding
Summary: Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing ... |
Does Knockout of Dna2 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Dna2 | protein/peptide distribution | myoblast cell line | Gene: Dna2 (DNA replication helicase/nuclease 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, DNA replication, DNA replication checkpoint signaling, DNA replication, Okazaki fragment processing, DNA r... |
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