prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Slc19a2 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Slc19a2 | protein/peptide accumulation | Microglial Cell Line | Gene: Slc19a2 (solute carrier family 19 (thiamine transporter), member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, pyridoxine transport, spermatogenesis, thiamine diphosphate biosynthetic process, thiamine transmembrane transport, thiamine tra... |
Does Knockout of Ttc33 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Ttc33 | protein/peptide distribution | myoblast cell line | Gene: Ttc33 (tetratricopeptide repeat domain 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D6K7
Entrez ID: 67515 |
Does Knockout of Dcps in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Dcps | cell proliferation | Embryonic Stem Cell Line | Gene: Dcps (decapping enzyme, scavenger)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA cis splicing, via spliceosome, mRNA methylguanosine-cap decapping, mRNA processing, nuclear-transcrib... |
Does Knockout of Myom1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Myom1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Myom1 (myomesin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extraocular skeletal muscle development, muscle contraction, positive regulation of gene expression, positive regulation of protein secretion, protein kinase A signaling, sarcomere organization; MF: ... |
Does Knockout of Abca14 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Abca14 | protein/peptide accumulation | Embryonic Cell Line | Gene: Abca14 (ATP-binding cassette, sub-family A member 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid transport, transmembrane transport; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity... |
Does Knockout of G6pdx in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | G6pdx | cell proliferation | Embryonic Stem Cell Line | Gene: G6pdx (glucose-6-phosphate dehydrogenase X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NADP+ biosynthetic process, NADP+ metabolic process, NADPH regeneration, angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressu... |
Does Knockout of GM20431 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | GM20431 | phagocytosis | macrophage | Gene: Gm20431 (predicted gene 20431)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Numbl in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,260 | Knockout | Numbl | cell proliferation | Mouse kidney carcinoma cell | Gene: Numbl (numb-like)
Type: protein-coding
Summary: Involved in lateral ventricle development; neuroblast division in subventricular zone; and positive regulation of neurogenesis. Acts upstream of or within adherens junction organization and nervous system development. Located in cytoplasm. Is express... |
Does Knockout of Acat3 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Acat3 | protein/peptide accumulation | Regulatory T cell | Gene: Acat3 (acetyl-Coenzyme A acetyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acetyl-CoA C-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, transferase activity; CC: cyt... |
Does Knockout of Pcdhga6 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Pcdhga6 | cell proliferation | Mouse kidney carcinoma cell | Gene: Pcdhga6 (protocadherin gamma subfamily A, 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, pl... |
Does Knockout of Slc39a8 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Slc39a8 | response to virus | Embryonic Fibroblast Cell Line | Gene: Slc39a8 (solute carrier family 39 (metal ion transporter), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, arginine metabolic process, bicarbonate transport, cadmium ion transmembrane transport, cartilage homeostasis, cellular ... |
Does Knockout of Ankra2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Ankra2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Ankra2 (ankyrin repeat family A member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of gene expression, regulation of protein-containing complex assembly; MF: histone deacetylase binding, low-density lipoprotein particle receptor binding, protein bi... |
Does Knockout of Tmod1 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Tmod1 | phagocytosis | macrophage | Gene: Tmod1 (tropomodulin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, adult locomotory behavior, lens fiber cell development, muscle contraction, myofibril assembly, pointed-end actin filament capping; MF: actin binding, tropomyosin bin... |
Does Knockout of Phgdh in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 165 | Knockout | Phgdh | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Phgdh (3-phosphoglycerate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1 to G0 transition, L-serine biosynthetic process, L-serine metabolic process, amino acid biosynthetic process, gamma-aminobutyric acid metabolic process, glial cell developmen... |
Does Knockout of Dnajc13 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Dnajc13 | cell proliferation | Melanoma Cell Line | Gene: Dnajc13 (DnaJ heat shock protein family (Hsp40) member C13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome organization, receptor-mediated endocytosis, regulation of early endosome to late endosome transport, regulation of early endosome to recycling endos... |
Does Knockout of Inpp4a in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Inpp4a | cell proliferation | Melanoma Cell Line | Gene: Inpp4a (inositol polyphosphate-4-phosphatase, type I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, phosphatidylinositol biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, polyphosphate catabolic process, regulati... |
Does Knockout of Trim12c in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Trim12c | response to bacteria | renal medulla cell line | Gene: Trim12c (tripartite motif-containing 12C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, autophagy, host-mediated suppression of symbiont invasion, innate immune response, positive regulation of MAPK cascade, positive regulatio... |
Does Knockout of Sprr1a in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Sprr1a | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Sprr1a (small proline-rich protein 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: keratinization, keratinocyte differentiation; CC: cell periphery, cornified envelope, cytoplasm
Pathways:
UniProt: Q62266
Entrez ID: 20753 |
Does Knockout of Slc6a1 in Microglial Cell Line causally result in phagocytosis? | 0 | 1,587 | Knockout | Slc6a1 | phagocytosis | Microglial Cell Line | Gene: Slc6a1 (solute carrier family 6 (neurotransmitter transporter, GABA), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transmembrane transport, amino acid transport, associative learning, chloride transmembrane transport, gamma-aminobutyric acid ... |
Does Knockout of Tank in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Tank | cell proliferation | Melanoma Cell Line | Gene: Tank (TRAF family member-associated Nf-kappa B activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cellular response to interleukin-1, cellular response to ionizing radiation, cellular response to tumor necrosis factor, negative regulatio... |
Does Knockout of Zswim5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Zswim5 | cell proliferation | Colonic Cancer Cell Line | Gene: Zswim5 (zinc finger SWIM-type containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q80TC6
Entrez ID: 74464 |
Does Knockout of Zfp229 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Zfp229 | cell proliferation | Colonic Cancer Cell Line | Gene: Zfp229 (zinc finger protein 229)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene ex... |
Does Knockout of Aldh2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Aldh2 | cell proliferation | Colonic Cancer Cell Line | Gene: Aldh2 (aldehyde dehydrogenase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetaldehyde metabolic process, aldehyde catabolic process, behavioral response to ethanol, cellular detoxification of aldehyde, ethanol catabolic process, ethanol metabo... |
Does Knockout of Mafk in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Mafk | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Mafk (v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA p... |
Does Knockout of Kmt2e in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 84 | Knockout | Kmt2e | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Kmt2e (lysine (K)-specific methyltransferase 2E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, epigenetic regulation of gene expression, erythrocyte differentiation, neutrophil activation, neutrophil mediated immunity,... |
Does Knockout of Col3a1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Col3a1 | protein/peptide distribution | myoblast cell line | Gene: Col3a1 (collagen, type III, alpha 1)
Type: protein-coding
Summary: This gene encodes the alpha-1 subunit of the fibril-forming type III collagen found in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue. The encoded protein forms homotrimeric type III procollagen tha... |
Does Knockout of Entpd2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Entpd2 | cell proliferation | Colonic Cancer Cell Line | Gene: Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to interleukin-6, nucleoside diphosphate catabolic process, nucleoside diphosphate metabolic pro... |
Does Knockout of Tnip1 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Tnip1 | phagocytosis | macrophage | Gene: Tnip1 (TNFAIP3 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MyD88-dependent toll-like receptor signaling pathway, cellular response to lipopolysaccharide, glycoprotein biosynthetic process, inflammatory response, leukocyte cell-cell adhesio... |
Does Knockout of Traf5 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Traf5 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Traf5 (TNF receptor-associated factor 5)
Type: protein-coding
Summary: Predicted to enable enzyme binding activity; identical protein binding activity; and signaling adaptor activity. Involved in interleukin-17-mediated signaling pathway and regulation of gene expression. Acts upstream of or withi... |
Does Knockout of Cfap69 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Cfap69 | cell proliferation | Mouse kidney carcinoma cell | Gene: Cfap69 (cilia and flagella associated protein 69)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, flagellated sperm motility, olfactory behavior, positive regulation of fertilization, positive regulation of flagellated sperm motility, response ... |
Does Knockout of Cops8 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Cops8 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Cops8 (COP9 signalosome subunit 8)
Type: protein-coding
Summary: Predicted to be involved in activation of NF-kappaB-inducing kinase activity; negative regulation of cell population proliferation; and protein modification process. Located in nucleus. Part of COP9 signalosome. Is expressed in sever... |
Does Knockout of Slc8a3 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Slc8a3 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Slc8a3 (solute carrier family 8 (sodium/calcium exchanger), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion export across plasma membrane, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, ca... |
Does Knockout of Cldn8 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Cldn8 | protein/peptide distribution | myoblast cell line | Gene: Cldn8 (claudin 8)
Type: protein-coding
Summary: This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through... |
Does Knockout of Vps25 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Vps25 | protein/peptide accumulation | Embryonic Cell Line | Gene: Vps25 (vacuolar protein sorting 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: macroautophagy, multivesicular body sorting pathway, protein transport, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular ... |
Does Knockout of Pyroxd2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Pyroxd2 | cell proliferation | Melanoma Cell Line | Gene: Pyroxd2 (pyridine nucleotide-disulphide oxidoreductase domain 2)
Type: protein-coding
Summary: Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial matrix. Orthologous to human PYROXD2 (pyridine nucleotide-dis... |
Does Knockout of Galnt9 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Galnt9 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Galnt9 (polypeptide N-acetylgalactosaminyltransferase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein O-linked glycosylation, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, molecular_f... |
Does Knockout of Trhde in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Trhde | cell cycle progression | breast epithelium | Gene: Trhde (TRH-degrading enzyme)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: peptide catabolic process, proteolysis; MF: aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, py... |
Does Knockout of Senp1 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,180 | Knockout | Senp1 | tumorigenicity | Colonic Cancer Cell Line | Gene: Senp1 (SUMO1/sentrin specific peptidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA destabilization, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, protein desu... |
Does Knockout of Pgrmc2 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Pgrmc2 | response to virus | Neuroblastoma Cell Line | Gene: Pgrmc2 (progesterone receptor membrane component 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, heme transport; MF: heme binding, heme transmembrane transporter activity, lipid binding, protein binding, steroid binding; CC: endomembra... |
Does Knockout of Ccdc170 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Ccdc170 | cell cycle progression | breast epithelium | Gene: Ccdc170 (coiled-coil domain containing 170)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization; MF: microtubule binding; CC: Golgi apparatus, cell junction, ciliary basal body
Pathways:
UniProt: F6ST92, D3YXL0, D... |
Does Knockout of Acss3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Acss3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Acss3 (acyl-CoA synthetase short-chain family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lipid metabolic process, small molecule metabolic process; MF: ATP binding, acetate-CoA ligase activity, ligase activity, medium-chain fatty a... |
Does Knockout of Bpnt1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Bpnt1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Bpnt1 (3'(2'), 5'-bisphosphate nucleotidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 3'(2'),5'-bisphosphate nucleotidase activity, hydrolase activity, inositol-1,4-bisphosphate 1-phosphatase activity, magnesium ion binding, metal ion binding
Pathw... |
Does Knockout of Zfp810 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Zfp810 | response to virus | Microglial Cell Line | Gene: Zfp810 (zinc finger protein 810)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymera... |
Does Knockout of Rsbn1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Rsbn1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Rsbn1 (rosbin, round spermatid basic protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, chromatin organization, chromatin remodeling; MF: dioxygenase activity, histone H4K20 demethylase activity, metal ion binding, oxidoreductase activity... |
Does Knockout of Zfp827 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Zfp827 | response to chemicals | pro-B-lymphocyte | Gene: Zfp827 (zinc finger protein 827)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, establishment of protein localization to telomere, negative regulation of DNA-templated transcription, negative regulation of shelterin complex assembly, positive ... |
Does Knockout of Tcaf3 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Tcaf3 | protein/peptide accumulation | Microglial Cell Line | Gene: Tcaf3 (TRPM8 channel-associated factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein binding, transmembrane transporter binding
Pathways:
UniProt: Q6QR59
Entrez ID: 403088 |
Does Knockout of Stpg4 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Stpg4 | protein/peptide accumulation | Regulatory T cell | Gene: Stpg4 (sperm tail PG rich repeat containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, epigenetic programing of male pronucleus, pyrimidine-containing compound catabolic process; MF: chromatin binding, histone binding, protein binding... |
Does Knockout of Fignl1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Fignl1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Fignl1 (fidgetin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, cellular response to ionizing radiation, male meiotic nuclear division, microtubule severing, negative regulation of apoptotic process, negative regulation of intrinsic a... |
Does Knockout of Zfp239 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Zfp239 | protein/peptide distribution | Microglial Cell Line | Gene: Zfp239 (zinc finger protein 239)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcr... |
Does Knockout of Ptgdr2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Ptgdr2 | cell proliferation | Melanoma Cell Line | Gene: Ptgdr2 (prostaglandin D2 receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, calcium-mediated signaling, chemotaxis, negative regulation ... |
Does Knockout of Ybx2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Ybx2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Ybx2 (Y box protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA stabilization, negative regulation of RNA metabolic process, negative regulation of macromolecule biosynthetic process, negative regulation of translation, oogenesis, positive regulation of ... |
Does Knockout of Hgsnat in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Hgsnat | cell proliferation | Colonic Cancer Cell Line | Gene: Hgsnat (heparan-alpha-glucosaminide N-acetyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heparan sulfate proteoglycan catabolic process, lysosomal transport, protein complex oligomerization; MF: acyltransferase activity, heparan-alpha-glucosaminide N... |
Does Knockout of Slc50a1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Slc50a1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Slc50a1 (solute carrier family 50 (sugar transporter), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate transmembrane transport, carbohydrate transport, glucoside transport; MF: glucoside transmembrane transporter activity, sugar transmembrane ... |
Does Knockout of Fxyd6 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Fxyd6 | cell proliferation | Mouse kidney carcinoma cell | Gene: Fxyd6 (FXYD domain-containing ion transport regulator 6)
Type: protein-coding
Summary: This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid sign... |
Does Knockout of Cyb5d2 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Cyb5d2 | protein/peptide accumulation | Regulatory T cell | Gene: Cyb5d2 (cytochrome b5 domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development, positive regulation of neuron differentiation; CC: endomembrane system, extracellular region, membrane
Pathways:
UniProt: Q5SSH8... |
Does Knockout of Chic2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Chic2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Chic2 (cysteine-rich hydrophobic domain 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, Golgi-associated vesicle, membrane, plasma membrane
Pathways:
UniProt: Q9D9G3
Entrez ID: 74277 |
Does Knockout of Tnfrsf9 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Tnfrsf9 | cell proliferation | Regulatory T cell | Gene: Tnfrsf9 (tumor necrosis factor receptor superfamily, member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of cell population proliferation, regulation of cell population proliferation, regulation of immature T cell prolife... |
Does Knockout of Ndufa13 in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,285 | Knockout | Ndufa13 | cell proliferation | Mouse kidney carcinoma cell | Gene: Ndufa13 (NADH:ubiquinone oxidoreductase subunit A13)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in mitochondrion and nucleus. Part of respiratory chain complex I. Is active in mitochondrial inner... |
Does Knockout of Prc1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Prc1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Prc1 (protein regulator of cytokinesis 1)
Type: protein-coding
Summary: Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell popu... |
Does Knockout of Atp13a1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Atp13a1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Atp13a1 (ATPase type 13A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extraction of mislocalized protein from ER membrane, intracellular calcium ion homeostasis, monoatomic cation transmembrane transport, protein transport, transmembrane transport; MF: ATP bind... |
Does Knockout of Slc12a6 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Slc12a6 | protein/peptide distribution | myoblast cell line | Gene: Slc12a6 (solute carrier family 12, member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell volume homeostasis, cellular hypotonic response, cellular hypotonic salinity response, cellular response to glucose stimulus, chemical synaptic transmission, chloride i... |
Does Knockout of Lpar1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Lpar1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Lpar1 (lysophosphatidic acid receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Golgi to plasma membrane protein transport, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cy... |
Does Knockout of Adora2b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Adora2b | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Adora2b (adenosine A2b receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled adenosine receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, negative... |
Does Knockout of Gm5458 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Gm5458 | phagocytosis | macrophage | Gene: Gm5458 (predicted gene 5458)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6P8Z5, L7N219
Entrez ID: 432825 |
Does Knockout of Zfp945 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Zfp945 | protein/peptide distribution | myoblast cell line | Gene: Zfp945 (zinc finger protein 945)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding tran... |
Does Knockout of Mrps18c in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Mrps18c | cell proliferation | Embryonic Stem Cell Line | Gene: Mrps18c (mitochondrial ribosomal protein S18C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small... |
Does Knockout of Naa11 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Naa11 | cell proliferation | Melanoma Cell Line | Gene: Naa11 (N(alpha)-acetyltransferase 11, NatA catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: N-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, protein N-terminal-serin... |
Does Knockout of Cdk5rap3 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Cdk5rap3 | cell proliferation | Mouse kidney carcinoma cell | Gene: Cdk5rap3 (CDK5 regulatory subunit associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic nuclear changes, cell population proliferation, definitive erythrocyte differentiation, endoplasmic reticulum unfolded protein response, liver developme... |
Does Knockout of Yy1 in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,559 | Knockout | Yy1 | response to chemicals | Lymphoma Cell Line | Gene: Yy1 (YY1 transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, DNA damage response, DNA recombination, DNA repair, RNA localization, anterior/posterior pattern specification, camera-type eye morphogenesis, cell differentiation... |
Does Knockout of Gria2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Gria2 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Gria2 (glutamate receptor, ionotropic, AMPA2 (alpha 2))
Type: protein-coding
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of g... |
Does Knockout of Mettl13 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Mettl13 | protein/peptide distribution | myoblast cell line | Gene: Mettl13 (methyltransferase 13, eEF1A lysine and N-terminal methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: catalytic activity, methyltransferase activity, molecular_function, protein-lysine N-methyltransferase activity, transferase activity; CC: c... |
Does Knockout of Klra21 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Klra21 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Klra21 (killer cell lectin-like receptor subfamily A, member 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9JHV1
Entrez ID: 93968 |
Does Knockout of Itga11 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Itga11 | protein/peptide distribution | myoblast cell line | Gene: Itga11 (integrin alpha 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell adhesion mediated by integrin, cell-cell adhesion, cell-matrix adhesion, collagen-activated signaling pathway, fibroblast migration, integrin-mediated signaling pathway, s... |
Does Knockout of Riok3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 1,664 | Knockout | Riok3 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Riok3 (RIO kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to dsDNA, cellular response to dsRNA, cellular response to virus, defense response to virus, immune system process, innate immune response, maturation of SSU-rRNA, negative regula... |
Does Knockout of Fam47c in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Fam47c | protein/peptide distribution | myoblast cell line | Gene: Fam47c (family with sequence similarity 47, member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, transcription initiation-coupled chromatin remodeling; CC: cellular_component, chromatin
Pathways:
UniProt: Q14BE7
En... |
Does Knockout of Cplx3 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,176 | Knockout | Cplx3 | cell proliferation | Colonic Cancer Cell Line | Gene: Cplx3 (complexin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, insulin secretion, modulation of chemical synaptic transmission, neurotransmitter transport, regulation of neurotransmitter secretion, regulation of synaptic vesicle fusion to presynapti... |
Does Knockout of Mgat4a in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Mgat4a | phagocytosis | macrophage | Gene: Mgat4a (mannoside acetylglucosaminyltransferase 4, isoenzyme A)
Type: protein-coding
Summary: Enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Involved in N-glycan processing. Acts upstream of or within protein N-linked glycosylation. Predicted to be located ... |
Does Knockout of Lemd1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Lemd1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Lemd1 (LEM domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q14C37
Entrez ID: 213409 |
Does Knockout of Cpa5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Cpa5 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Cpa5 (carboxypeptidase A5)
Type: protein-coding
Summary: This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is exp... |
Does Knockout of St3gal4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | St3gal4 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: St3gal4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cognition, glycolipid biosynthetic process, glycoprotein biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, positive regula... |
Does Knockout of Psors1c2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Psors1c2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Psors1c2 (psoriasis susceptibility 1 candidate 2 (human))
Type: protein-coding
Summary: Predicted to be located in extracellular region. Orthologous to human PSORS1C2 (psoriasis susceptibility 1 candidate 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular... |
Does Knockout of Try5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Try5 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Try5 (trypsin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: calcium ion binding, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: acrosomal vesicle, cytoplasmic vesicle, extracellul... |
Does Knockout of Trim14 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Trim14 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Trim14 (tripartite motif-containing 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, inflammatory response, innate immune response, negative regulation of viral transcription, positive regulation of DNA-templated transcription, protein K48-... |
Does Knockout of Cib1 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Cib1 | cell proliferation | Embryonic Stem Cell Line | Gene: Cib1 (calcium and integrin binding 1)
Type: protein-coding
Summary: Enables protein-membrane adaptor activity and transmembrane transporter binding activity. Involved in several processes, including negative regulation of megakaryocyte differentiation; regulation of intracellular signal transducti... |
Does Knockout of Lrrc8c in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Lrrc8c | cell proliferation | Embryonic Stem Cell Line | Gene: Lrrc8c (leucine rich repeat containing 8 family, member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aspartate transmembrane transport, cellular response to osmotic stress, cyclic-GMP-AMP transmembrane import across plasma membrane, fat cell differentiation, m... |
Does Knockout of Lpp in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Lpp | cell proliferation | Mouse kidney carcinoma cell | Gene: Lpp (LIM domain containing preferred translocation partner in lipoma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion; MF: metal ion binding, protein binding; CC: anchoring junction, cytoplasm, cytosol, focal adhesion, nucleus, plas... |
Does Knockout of Qpctl in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,179 | Knockout | Qpctl | cell proliferation | Colonic Cancer Cell Line | Gene: Qpctl (glutaminyl-peptide cyclotransferase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acyltransferase activity, glutaminyl-peptide cyclotransferase activity, metal ion binding, transferase activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, m... |
Does Knockout of Prr16 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Prr16 | cell proliferation | Mouse kidney carcinoma cell | Gene: Prr16 (proline rich 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell size, positive regulation of translation
Pathways:
UniProt: A3KMN5
Entrez ID: 71373 |
Does Knockout of Srgap3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Srgap3 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Srgap3 (SLIT-ROBO Rho GTPase activating protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell migration, nervous system development, regulation of postsynapse assembly, regulation of synapse assembly, signal transduction; MF: GTPase ... |
Does Knockout of Ppp1r10 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Ppp1r10 | response to chemicals | pro-B-lymphocyte | Gene: Ppp1r10 (protein phosphatase 1, regulatory subunit 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, negative regulation of cardiac muscle cell apoptotic process, negative regulation of mitotic DNA damage checkpoint, negative ... |
Does Knockout of Nploc4 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Nploc4 | protein/peptide accumulation | Microglial Cell Line | Gene: Nploc4 (NPL4 homolog, ubiquitin recognition factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, Golgi organization, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, proteasome-mediated ubiquitin-d... |
Does Knockout of Trav5-1 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Trav5-1 | phagocytosis | macrophage | Gene: Trav5-1 (T cell receptor alpha variable 5-1)
Type: other
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune system process, response to bacterium
Pathways:
UniProt:
Entrez ID: 633740 |
Does Knockout of Nup205 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,683 | Knockout | Nup205 | protein/peptide distribution | myoblast cell line | Gene: Nup205 (nucleoporin 205)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport; MF: structural constituent of nuclear pore; CC: nuclear envelope, nuclear membrane, nuclear periphery, nuc... |
Does Knockout of Bmp7 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Bmp7 | protein/peptide distribution | myoblast cell line | Gene: Bmp7 (bone morphogenetic protein 7)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription... |
Does Knockout of Amer2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Amer2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Amer2 (APC membrane recruitment 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, ectoderm development, negative regulation of canonical Wnt signaling pathway, regulation of canonical Wnt signaling pathway; MF: beta-catenin binding, lipid bin... |
Does Knockout of Arl6ip5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Arl6ip5 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Arl6ip5 (ADP-ribosylation factor-like 6 interacting protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate import across plasma membrane, L-glutamate transmembrane transport, cellular response to oxidative stress, glutathione metabolic process, intri... |
Does Knockout of Ctsl in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Ctsl | response to chemicals | pro-B-lymphocyte | Gene: Ctsl (cathepsin L)
Type: protein-coding
Summary: This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and the cathepsin L1 he... |
Does Knockout of Calhm1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Calhm1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Calhm1 (calcium homeostasis modulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP export, ATP transport, calcium ion transmembrane transport, calcium ion transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transp... |
Does Knockout of Med23 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Med23 | response to virus | Microglial Cell Line | Gene: Med23 (mediator complex subunit 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of T cell extravasation, positive regulation of gene expression, positive regulation of transcription elongation... |
Does Knockout of Api5 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Api5 | cell proliferation | Mouse kidney carcinoma cell | Gene: Api5 (apoptosis inhibitor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, negative regulation of fibroblast apoptotic process; MF: RNA binding, fibroblast growth factor binding; CC: cytoplasm, nuclear s... |
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