prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Slc19a2 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Slc19a2
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Slc19a2 (solute carrier family 19 (thiamine transporter), member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, pyridoxine transport, spermatogenesis, thiamine diphosphate biosynthetic process, thiamine transmembrane transport, thiamine transport, transmembrane transport, vitamin transport; MF: protein binding, thiamine transmembrane transporter activity, vitamin transmembrane transporter activity; CC: membrane, plasma membrane
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Vitamin B1 (thiamin) metabolism, Vitamin digestion and absorption - Mus musculus (mouse)
UniProt: Q9EQN9
Entrez ID: 116914
|
Does Knockout of Ttc33 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Ttc33
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ttc33 (tetratricopeptide repeat domain 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D6K7
Entrez ID: 67515
|
Does Knockout of Dcps in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Dcps
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dcps (decapping enzyme, scavenger)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA cis splicing, via spliceosome, mRNA methylguanosine-cap decapping, mRNA processing, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; MF: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity, RNA 7-methylguanosine cap binding, hydrolase activity, identical protein binding; CC: P-body, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Mus musculus (mouse), mRNA decay by 3' to 5' exoribonuclease
UniProt: Q9DAR7
Entrez ID: 69305
|
Does Knockout of Myom1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Myom1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Myom1 (myomesin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extraocular skeletal muscle development, muscle contraction, positive regulation of gene expression, positive regulation of protein secretion, protein kinase A signaling, sarcomere organization; MF: identical protein binding, kinase binding, protein homodimerization activity, structural constituent of cytoskeleton, structural molecule activity; CC: M band, cytoplasm, cytoskeleton, myosin filament, sarcomere
Pathways:
UniProt: Q62234
Entrez ID: 17929
|
Does Knockout of Abca14 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Abca14
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Abca14 (ATP-binding cassette, sub-family A member 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid transport, transmembrane transport; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, lipid transporter activity, nucleotide binding; CC: cytoplasm, endomembrane system, intracellular membrane-bounded organelle, membrane
Pathways: ABC transporters - Mus musculus (mouse)
UniProt: E9Q8F8
Entrez ID: 67928
|
Does Knockout of G6pdx in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
G6pdx
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: G6pdx (glucose-6-phosphate dehydrogenase X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NADP+ biosynthetic process, NADP+ metabolic process, NADPH regeneration, angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure, angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure, cellular response to oxidative stress, cholesterol biosynthetic process, erythrocyte development, erythrocyte maturation, glucose 6-phosphate metabolic process, glucose metabolic process, glutathione metabolic process, negative regulation of cell growth involved in cardiac muscle cell development, negative regulation of reactive oxygen species metabolic process, pentose biosynthetic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch, positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of multicellular organism growth, regulation of neuron apoptotic process, response to ethanol, response to oxidative stress, ribose phosphate biosynthetic process; MF: D-glucose binding, NADP binding, carbohydrate binding, glucose-6-phosphate dehydrogenase activity, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors, protein homodimerization activity; CC: centriolar satellite, cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glutathione metabolism - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), RNA Polymerase II Transcription, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, formaldehyde oxidation I, pentose phosphate pathway, pentose phosphate pathway (oxidative branch)
UniProt: Q00612
Entrez ID: 14381
|
Does Knockout of GM20431 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
GM20431
|
phagocytosis
|
macrophage
|
Gene: Gm20431 (predicted gene 20431)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Numbl in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Numbl
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Numbl (numb-like)
Type: protein-coding
Summary: Involved in lateral ventricle development; neuroblast division in subventricular zone; and positive regulation of neurogenesis. Acts upstream of or within adherens junction organization and nervous system development. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; peripheral nervous system ganglion; and sensory organ. Orthologous to human NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: adherens junction organization, axonogenesis, cytokine-mediated signaling pathway, forebrain development, lateral ventricle development, nervous system development, neuroblast division in subventricular zone, neuroblast proliferation, positive regulation of dendrite morphogenesis, positive regulation of neurogenesis, protein metabolic process, regulation of postsynapse assembly; CC: cytoplasm, glutamatergic synapse
Pathways: Notch signaling pathway - Mus musculus (mouse)
UniProt: O08919
Entrez ID: 18223
|
Does Knockout of Acat3 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Acat3
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Acat3 (acetyl-Coenzyme A acetyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acetyl-CoA C-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, transferase activity; CC: cytoplasm, mitochondrion
Pathways: Butanoate metabolism - Mus musculus (mouse), Fat digestion and absorption - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse), Pyruvate metabolism - Mus musculus (mouse), Terpenoid backbone biosynthesis - Mus musculus (mouse), Tryptophan metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse)
UniProt: Q80X81
Entrez ID: 224530
|
Does Knockout of Pcdhga6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Pcdhga6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcdhga6 (protocadherin gamma subfamily A, 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q91XY2
Entrez ID: 93714
|
Does Knockout of Slc39a8 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Slc39a8
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Slc39a8 (solute carrier family 39 (metal ion transporter), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, arginine metabolic process, bicarbonate transport, cadmium ion transmembrane transport, cartilage homeostasis, cellular detoxification of cadmium ion, cobalt ion transport, extracellular matrix organization, intracellular manganese ion homeostasis, intracellular monoatomic cation homeostasis, intracellular zinc ion homeostasis, iron ion import across plasma membrane, leukocyte adhesion to arterial endothelial cell, manganese ion transmembrane transport, mercury ion transport, metal ion transport, mitochondrial manganese ion transmembrane transport, monoatomic ion transport, negative regulation of canonical NF-kappaB signal transduction, negative regulation of inflammatory response, plasma membrane selenite transport, protein N-linked glycosylation, regulation of DNA-templated transcription, regulation of membrane potential, transmembrane transport, zinc ion import across plasma membrane, zinc ion transmembrane transport, zinc ion transport; MF: metal ion transmembrane transporter activity, monoatomic cation:bicarbonate symporter activity, symporter activity, zinc ion transmembrane transporter activity, zinc:bicarbonate symporter activity; CC: apical plasma membrane, basolateral plasma membrane, lysosomal membrane, lysosome, membrane, organelle membrane, plasma membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Ferroptosis - Mus musculus (mouse), Metal ion SLC transporters, Parkinson disease - Mus musculus (mouse), SLC-mediated transmembrane transport, Transport of small molecules, Zinc influx into cells by the SLC39 gene family, Zinc transporters
UniProt: Q91W10
Entrez ID: 67547
|
Does Knockout of Ankra2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Ankra2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ankra2 (ankyrin repeat family A member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of gene expression, regulation of protein-containing complex assembly; MF: histone deacetylase binding, low-density lipoprotein particle receptor binding, protein binding, protein kinase binding, ubiquitin protein ligase binding; CC: 3M complex, cytoplasm, cytoskeleton, cytosol, membrane, nucleus, protein-containing complex
Pathways:
UniProt: Q99PE2
Entrez ID: 68558
|
Does Knockout of Tmod1 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Tmod1
|
phagocytosis
|
macrophage
|
Gene: Tmod1 (tropomodulin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, adult locomotory behavior, lens fiber cell development, muscle contraction, myofibril assembly, pointed-end actin filament capping; MF: actin binding, tropomyosin binding; CC: COP9 signalosome, actin filament, cortical cytoskeleton, cytoplasm, cytoskeleton, membrane, myofibril, sarcomere, striated muscle thin filament
Pathways: Muscle contraction, Striated Muscle Contraction
UniProt: P49813
Entrez ID: 21916
|
Does Knockout of Phgdh in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Phgdh
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Phgdh (3-phosphoglycerate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1 to G0 transition, L-serine biosynthetic process, L-serine metabolic process, amino acid biosynthetic process, gamma-aminobutyric acid metabolic process, glial cell development, glutamine metabolic process, glycine metabolic process, neural tube development, neurogenesis, neuron projection development, regulation of gene expression, serine family amino acid metabolic process, spinal cord development, taurine metabolic process, threonine metabolic process; MF: NAD binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, phosphoglycerate dehydrogenase activity
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Glycine, serine and threonine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Serine metabolism, serine biosynthesis, superpathway of serine and glycine biosynthesis I
UniProt: Q61753
Entrez ID: 236539
|
Does Knockout of Dnajc13 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Dnajc13
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dnajc13 (DnaJ heat shock protein family (Hsp40) member C13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome organization, receptor-mediated endocytosis, regulation of early endosome to late endosome transport, regulation of early endosome to recycling endosome transport; CC: WASH complex, cytosol, early endosome membrane, endosome membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: G3X922, D4AFX7, Q8CHD7, Q8BNL1, Q3TNE7, A0A1L1STR9, A0A087WS25, A0A087WRC9, A0A087WSI0
Entrez ID: 235567
|
Does Knockout of Inpp4a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Inpp4a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Inpp4a (inositol polyphosphate-4-phosphatase, type I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, phosphatidylinositol biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, polyphosphate catabolic process, regulation of postsynaptic membrane neurotransmitter receptor levels, small molecule metabolic process; MF: hydrolase activity, inositol-1,3,4-trisphosphate 4-phosphatase activity, inositol-3,4-bisphosphate 4-phosphatase activity, phosphatase activity, phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; CC: cytoplasm, early endosome membrane, endosome, glutamatergic synapse, membrane, nuclear membrane, nucleoplasm, nucleus, organelle, plasma membrane, postsynaptic density, recycling endosome membrane, synapse
Pathways: Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Synthesis of IP2, IP, and Ins in the cytosol, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the plasma membrane
UniProt: Q9EPW0
Entrez ID: 269180
|
Does Knockout of Trim12c in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Trim12c
|
response to bacteria
|
renal medulla cell line
|
Gene: Trim12c (tripartite motif-containing 12C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, autophagy, host-mediated suppression of symbiont invasion, innate immune response, positive regulation of MAPK cascade, positive regulation of canonical NF-kappaB signal transduction, protein K63-linked ubiquitination, regulation of gene expression, regulation of lipopolysaccharide-mediated signaling pathway, regulation of protein localization, regulation of viral entry into host cell, suppression of viral release by host; MF: identical protein binding, metal ion binding, pattern recognition receptor activity, protein homodimerization activity, protein kinase binding, protein-macromolecule adaptor activity, transcription coactivator activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: P-body, cytoplasm, omegasome
Pathways: Human immunodeficiency virus 1 infection - Mus musculus (mouse)
UniProt: D3Z3L3
Entrez ID: 319236
|
Does Knockout of Sprr1a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Sprr1a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Sprr1a (small proline-rich protein 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: keratinization, keratinocyte differentiation; CC: cell periphery, cornified envelope, cytoplasm
Pathways:
UniProt: Q62266
Entrez ID: 20753
|
Does Knockout of Slc6a1 in Microglial Cell Line causally result in phagocytosis?
| 0
| 1,587
|
Knockout
|
Slc6a1
|
phagocytosis
|
Microglial Cell Line
|
Gene: Slc6a1 (solute carrier family 6 (neurotransmitter transporter, GABA), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transmembrane transport, amino acid transport, associative learning, chloride transmembrane transport, gamma-aminobutyric acid import, inorganic anion import across plasma membrane, learning, memory, negative regulation of synaptic transmission, GABAergic, neurotransmitter reuptake, neurotransmitter transport, positive regulation of gamma-aminobutyric acid secretion, response to purine-containing compound, response to toxic substance, sodium ion import across plasma membrane, sodium ion transmembrane transport, synapse organization; MF: amino acid:sodium symporter activity, gamma-aminobutyric acid transmembrane transporter activity, gamma-aminobutyric acid:sodium:chloride symporter activity, identical protein binding, metal ion binding, sodium:chloride symporter activity, symporter activity; CC: GABA-ergic synapse, axon, cell projection, cell surface, membrane, neuronal cell body, plasma membrane, postsynaptic membrane, presynapse, presynaptic membrane, synapse
Pathways: GABA synthesis, release, reuptake and degradation, GABAergic synapse - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, Reuptake of GABA, SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules
UniProt: P31648
Entrez ID: 232333
|
Does Knockout of Tank in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Tank
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tank (TRAF family member-associated Nf-kappa B activator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cellular response to interleukin-1, cellular response to ionizing radiation, cellular response to tumor necrosis factor, negative regulation of canonical NF-kappaB signal transduction, negative regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein deubiquitination, positive regulation of type I interferon production, positive regulation of ubiquitin-specific protease activity; MF: cysteine-type deubiquitinase activity, deubiquitinase activator activity, metal ion binding, molecular adaptor activity, molecular function inhibitor activity, protein binding, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Immune System, Innate Immune System, Lipid and atherosclerosis - Mus musculus (mouse), MyD88-independent TLR4 cascade , NOD-like receptor signaling pathway - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades
UniProt: P70347
Entrez ID: 21353
|
Does Knockout of Zswim5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Zswim5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zswim5 (zinc finger SWIM-type containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q80TC6
Entrez ID: 74464
|
Does Knockout of Zfp229 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Zfp229
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfp229 (zinc finger protein 229)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q80ZY7, E9PWT2, S4R1L0, S4R233
Entrez ID: 381067
|
Does Knockout of Aldh2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Aldh2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Aldh2 (aldehyde dehydrogenase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetaldehyde metabolic process, aldehyde catabolic process, behavioral response to ethanol, cellular detoxification of aldehyde, ethanol catabolic process, ethanol metabolic process, intrinsic apoptotic signaling pathway in response to oxidative stress, negative regulation of apoptotic process, nitroglycerin metabolic process, regulation of dopamine biosynthetic process, regulation of reactive oxygen species metabolic process, regulation of serotonin biosynthetic process; MF: NAD binding, NADH binding, aldehyde dehydrogenase (NAD+) activity, carboxylesterase activity, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, phenylacetaldehyde dehydrogenase (NAD+) activity, protein binding; CC: mitochondrial matrix, mitochondrion
Pathways: β-alanine biosynthesis I, Alcoholic liver disease - Mus musculus (mouse), Arginine and proline metabolism - Mus musculus (mouse), Ascorbate and aldarate metabolism - Mus musculus (mouse), Biological oxidations, Ethanol oxidation, Fatty acid degradation - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), Histidine metabolism - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of proteins, Metabolism of serotonin, Mitochondrial protein degradation, Neuronal System, Neurotransmitter clearance, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Phase I - Functionalization of compounds, Pyruvate metabolism - Mus musculus (mouse), Serotonin clearance from the synaptic cleft, Transmission across Chemical Synapses, Tryptophan metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), beta-Alanine metabolism - Mus musculus (mouse), dopamine degradation, ethanol degradation II (cytosol), fatty acid α-oxidation, putrescine degradation III
UniProt: P47738
Entrez ID: 11669
|
Does Knockout of Mafk in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Mafk
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Mafk (v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Factors involved in megakaryocyte development and platelet production, Heme signaling, Hemostasis, KEAP1-NFE2L2 pathway, Regulation of BACH1 activity
UniProt: Q61827
Entrez ID: 17135
|
Does Knockout of Kmt2e in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Kmt2e
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kmt2e (lysine (K)-specific methyltransferase 2E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, epigenetic regulation of gene expression, erythrocyte differentiation, neutrophil activation, neutrophil mediated immunity, positive regulation of DNA-templated transcription, positive regulation of G1/S transition of mitotic cell cycle, regulation of DNA-templated transcription, regulation of cell cycle, regulation of gene expression, retinoic acid receptor signaling pathway; MF: enzyme binding, histone H3K4 methyltransferase activity, histone H3K4me3 reader activity, metal ion binding, transcription coactivator activity, zinc ion binding; CC: Rpd3L-Expanded complex, Set3 complex, centrosome, chromatin, chromosome, cytoplasm, cytoskeleton, euchromatin, nuclear body, nuclear speck, nucleoplasm, nucleus, protein-containing complex
Pathways: Lysine degradation - Mus musculus (mouse)
UniProt: Q3UG20
Entrez ID: 69188
|
Does Knockout of Col3a1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Col3a1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Col3a1 (collagen, type III, alpha 1)
Type: protein-coding
Summary: This gene encodes the alpha-1 subunit of the fibril-forming type III collagen found in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue. The encoded protein forms homotrimeric type III procollagen that undergoes proteolytic processing during fibril formation. A majority of mice lacking the encoded protein die within two days of birth but about 5% of the animals survive to adulthood. The surviving mice exhibit severe cortical malformation and experience significantly shorter lifespan. The mutant mouse named 'tight skin 2' exhibiting systemic sclerosis phenotype was found to harbor a missense point mutation in this gene. A pseudogene of this gene has been defined on chromosome 8. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: aorta development, aorta smooth muscle tissue morphogenesis, basement membrane organization, blood vessel development, cartilage development, cell-matrix adhesion, cellular response to amino acid stimulus, cerebral cortex development, chondrocyte differentiation, collagen fibril organization, digestive tract development, elastic fiber assembly, endochondral bone morphogenesis, extracellular matrix organization, fibroblast proliferation, gene expression, heart development, in utero embryonic development, integrin-mediated signaling pathway, layer formation in cerebral cortex, limb joint morphogenesis, lung development, multicellular organism growth, negative regulation of immune response, negative regulation of neuron migration, neuron migration, positive regulation of Rho protein signal transduction, response to angiotensin, response to cytokine, response to radiation, skeletal system development, skin development, supramolecular fiber organization, tissue homeostasis, transforming growth factor beta receptor signaling pathway, transforming growth factor beta1 production, wound healing; MF: SMAD binding, extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, integrin binding, metal ion binding, platelet-derived growth factor binding, protease binding; CC: collagen trimer, collagen type III trimer, extracellular matrix, extracellular region, extracellular space
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adaptive Immune System, Amoebiasis - Mus musculus (mouse), Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), ECM proteoglycans, Extracellular matrix organization, Fibronectin matrix formation, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Integrin cell surface interactions, MET activates PTK2 signaling, MET promotes cell motility, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Non-integrin membrane-ECM interactions, Platelet activation - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases
UniProt: P08121
Entrez ID: 12825
|
Does Knockout of Entpd2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Entpd2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to interleukin-6, nucleoside diphosphate catabolic process, nucleoside diphosphate metabolic process, platelet activation, purine ribonucleoside diphosphate catabolic process, ribonucleoside triphosphate catabolic process; MF: ADP phosphatase activity, ATP binding, ATP hydrolysis activity, GDP phosphatase activity, UDP phosphatase activity, apyrase activity, hydrolase activity, identical protein binding, nucleoside diphosphate phosphatase activity, nucleotide binding, protein binding, ribonucleoside triphosphate phosphatase activity; CC: basement membrane, cell body, cell projection membrane, cell surface, membrane, plasma membrane
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Phosphate bond hydrolysis by NTPDase proteins, Purine metabolism - Mus musculus (mouse), Taste transduction - Mus musculus (mouse)
UniProt: O55026
Entrez ID: 12496
|
Does Knockout of Tnip1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Tnip1
|
phagocytosis
|
macrophage
|
Gene: Tnip1 (TNFAIP3 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MyD88-dependent toll-like receptor signaling pathway, cellular response to lipopolysaccharide, glycoprotein biosynthetic process, inflammatory response, leukocyte cell-cell adhesion, negative regulation of ERK1 and ERK2 cascade, negative regulation of canonical NF-kappaB signal transduction, positive regulation of inflammatory response, positive regulation of macromolecule metabolic process, positive regulation of protein deubiquitination, positive regulation of transcription by RNA polymerase II, regulation of primary metabolic process, regulation of transcription by RNA polymerase II; MF: identical protein binding, mitogen-activated protein kinase binding, polyubiquitin modification-dependent protein binding, protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Ovarian tumor domain proteases, Post-translational protein modification
UniProt: Q9WUU8
Entrez ID: 57783
|
Does Knockout of Traf5 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Traf5
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Traf5 (TNF receptor-associated factor 5)
Type: protein-coding
Summary: Predicted to enable enzyme binding activity; identical protein binding activity; and signaling adaptor activity. Involved in interleukin-17-mediated signaling pathway and regulation of gene expression. Acts upstream of or within positive regulation of cell population proliferation and signal transduction. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in genitourinary system and tongue muscle. Orthologous to human TRAF5 (TNF receptor associated factor 5). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: CD40 signaling pathway, apoptotic process, cell surface receptor signaling pathway, interleukin-17-mediated signaling pathway, mRNA stabilization, positive regulation of NF-kappaB transcription factor activity, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell population proliferation, regulation of apoptotic process, regulation of canonical NF-kappaB signal transduction, signal transduction, signal transduction involved in regulation of gene expression, tumor necrosis factor-mediated signaling pathway; MF: identical protein binding, metal ion binding, protein binding, signaling adaptor activity, thioesterase binding, tumor necrosis factor receptor binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, zinc ion binding; CC: CD40 receptor complex, centrosome, cytoplasm, cytoplasmic side of plasma membrane, cytosol
Pathways: Epstein-Barr virus infection - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P70191
Entrez ID: 22033
|
Does Knockout of Cfap69 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Cfap69
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cfap69 (cilia and flagella associated protein 69)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, flagellated sperm motility, olfactory behavior, positive regulation of fertilization, positive regulation of flagellated sperm motility, response to odorant, sensory perception of smell, sperm axoneme assembly, spermatogenesis; MF: molecular_function, protein binding; CC: axonemal central pair projection, cell projection, cilium, cytoplasm, motile cilium, non-motile cilium, sperm midpiece
Pathways:
UniProt: Q8BH53
Entrez ID: 207686
|
Does Knockout of Cops8 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Cops8
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Cops8 (COP9 signalosome subunit 8)
Type: protein-coding
Summary: Predicted to be involved in activation of NF-kappaB-inducing kinase activity; negative regulation of cell population proliferation; and protein modification process. Located in nucleus. Part of COP9 signalosome. Is expressed in several structures, including early embryo; liver; and oocyte. Orthologous to human COPS8 (COP9 signalosome subunit 8). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: COP9 signalosome assembly, negative regulation of cell population proliferation, protein deneddylation; CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q8VBV7
Entrez ID: 108679
|
Does Knockout of Slc8a3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Slc8a3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Slc8a3 (solute carrier family 8 (sodium/calcium exchanger), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion export across plasma membrane, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, calcium ion transport into cytosol, cell communication, cellular response to cAMP, cellular response to hypoxia, hematopoietic progenitor cell differentiation, intracellular calcium ion homeostasis, learning, learning or memory, long-term synaptic potentiation, memory, metal ion transport, mitochondrial calcium ion homeostasis, mitochondrial calcium ion transmembrane transport, modulation of excitatory postsynaptic potential, monoatomic ion transport, myelination, negative regulation of intracellular signal transduction, oligodendrocyte differentiation, regulation of postsynaptic cytosolic calcium ion concentration, regulation of skeletal muscle contraction, regulation of system process, sodium ion transmembrane transport, sodium ion transport, synapse organization, telencephalon development, transmembrane transport; MF: antiporter activity, calcium:monoatomic cation antiporter activity, calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration, calcium:sodium antiporter activity, calmodulin binding, metal ion binding; CC: anchoring junction, axon, axon terminus, cell projection, centrosome, cytoplasm, cytosol, dendrite, dendritic spine, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, microtubule, microtubule cytoskeleton, mitochondrial outer membrane, mitochondrion, neuromuscular junction, neuronal cell body, nucleoplasm, organelle, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynapse, postsynaptic density, postsynaptic membrane, sarcolemma, sarcoplasm, synapse
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Hemostasis, Hypertrophic cardiomyopathy - Mus musculus (mouse), Ion homeostasis, Metal ion SLC transporters, Mineral absorption - Mus musculus (mouse), Muscle contraction, Olfactory transduction - Mus musculus (mouse), Platelet calcium homeostasis, Platelet homeostasis, Protein digestion and absorption - Mus musculus (mouse), Reduction of cytosolic Ca++ levels, SLC-mediated transmembrane transport, Sodium/Calcium exchangers, Transport of small molecules, cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: S4R2P9
Entrez ID: 110893
|
Does Knockout of Cldn8 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Cldn8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cldn8 (claudin 8)
Type: protein-coding
Summary: This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a paracellular cation barrier. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: bicellular tight junction assembly, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion; MF: identical protein binding, protein binding, structural molecule activity; CC: anchoring junction, apicolateral plasma membrane, basolateral plasma membrane, bicellular tight junction, membrane, plasma membrane, tight junction
Pathways: Cell adhesion molecules - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: Q9Z260
Entrez ID: 54420
|
Does Knockout of Vps25 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Vps25
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vps25 (vacuolar protein sorting 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: macroautophagy, multivesicular body sorting pathway, protein transport, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; MF: protein homodimerization activity, structural molecule activity; CC: ESCRT II complex, cytoplasm, cytosol, endosome, endosome membrane, membrane, mitochondrion, nucleus
Pathways: Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9CQ80
Entrez ID: 28084
|
Does Knockout of Pyroxd2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Pyroxd2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pyroxd2 (pyridine nucleotide-disulphide oxidoreductase domain 2)
Type: protein-coding
Summary: Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial matrix. Orthologous to human PYROXD2 (pyridine nucleotide-disulphide oxidoreductase domain 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrion organization; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q3U4I7
Entrez ID: 74580
|
Does Knockout of Galnt9 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Galnt9
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Galnt9 (polypeptide N-acetylgalactosaminyltransferase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein O-linked glycosylation, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, molecular_function, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification
UniProt: G3X942, Q3TB05, A0A0G2JGP7
Entrez ID: 231605
|
Does Knockout of Trhde in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Trhde
|
cell cycle progression
|
breast epithelium
|
Gene: Trhde (TRH-degrading enzyme)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: peptide catabolic process, proteolysis; MF: aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, pyroglutamyl-peptidase activity, zinc ion binding; CC: extracellular space, membrane
Pathways:
UniProt: Q8K093
Entrez ID: 237553
|
Does Knockout of Senp1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Senp1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Senp1 (SUMO1/sentrin specific peptidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA destabilization, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, protein desumoylation, protein sumoylation, proteolysis, regulation of definitive erythrocyte differentiation, regulation of mRNA stability, regulation of macromolecule metabolic process, regulation of postsynapse assembly, regulation of primary metabolic process; MF: SUMO-specific endopeptidase activity, cysteine-type peptidase activity, deSUMOylase activity, hydrolase activity, peptidase activity, protein binding; CC: cytoplasm, focal adhesion, glutamatergic synapse, nuclear membrane, nucleoplasm, nucleus, postsynaptic cytosol, presynaptic cytosol
Pathways: Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, RHO GTPase cycle, RHOF GTPase cycle, SUMO is proteolytically processed, SUMOylation, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P59110
Entrez ID: 223870
|
Does Knockout of Pgrmc2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Pgrmc2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Pgrmc2 (progesterone receptor membrane component 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, heme transport; MF: heme binding, heme transmembrane transporter activity, lipid binding, protein binding, steroid binding; CC: endomembrane system, endoplasmic reticulum, extracellular region, glutamatergic synapse, membrane, nuclear envelope, nucleus, synapse
Pathways: Cellular responses to stimuli, Cellular responses to stress, Heme signaling, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOD GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80UU9
Entrez ID: 70804
|
Does Knockout of Ccdc170 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Ccdc170
|
cell cycle progression
|
breast epithelium
|
Gene: Ccdc170 (coiled-coil domain containing 170)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization; MF: microtubule binding; CC: Golgi apparatus, cell junction, ciliary basal body
Pathways:
UniProt: F6ST92, D3YXL0, D3Z4M1
Entrez ID: 100504234
|
Does Knockout of Acss3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Acss3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Acss3 (acyl-CoA synthetase short-chain family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lipid metabolic process, small molecule metabolic process; MF: ATP binding, acetate-CoA ligase activity, ligase activity, medium-chain fatty acid-CoA ligase activity, molecular_function, nucleotide binding, propionate-CoA ligase activity; CC: mitochondrial matrix, mitochondrion
Pathways: Ketone body metabolism, Metabolism, Metabolism of lipids, Propanoate metabolism - Mus musculus (mouse), Synthesis of Ketone Bodies, acetate conversion to acetyl-CoA, ethanol degradation II (cytosol)
UniProt: Q14DH7
Entrez ID: 380660
|
Does Knockout of Bpnt1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Bpnt1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bpnt1 (3'(2'), 5'-bisphosphate nucleotidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 3'(2'),5'-bisphosphate nucleotidase activity, hydrolase activity, inositol-1,4-bisphosphate 1-phosphatase activity, magnesium ion binding, metal ion binding
Pathways: Biological oxidations, Cytosolic sulfonation of small molecules, Metabolism, Phase II - Conjugation of compounds, Sulfur metabolism - Mus musculus (mouse)
UniProt: Q9Z0S1
Entrez ID: 23827
|
Does Knockout of Zfp810 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Zfp810
|
response to virus
|
Microglial Cell Line
|
Gene: Zfp810 (zinc finger protein 810)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, molecular_function, zinc ion binding; CC: cellular_component, nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: A0A1L1SUL0, Q99K45
Entrez ID: 235050
|
Does Knockout of Rsbn1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Rsbn1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rsbn1 (rosbin, round spermatid basic protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, chromatin organization, chromatin remodeling; MF: dioxygenase activity, histone H4K20 demethylase activity, metal ion binding, oxidoreductase activity, protein binding; CC: nucleus
Pathways:
UniProt: Q80T69
Entrez ID: 229675
|
Does Knockout of Zfp827 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Zfp827
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Zfp827 (zinc finger protein 827)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, establishment of protein localization to telomere, negative regulation of DNA-templated transcription, negative regulation of shelterin complex assembly, positive regulation of transcription by RNA polymerase II, telomere maintenance; MF: DNA binding, NuRD complex binding, metal ion binding, zinc ion binding; CC: chromatin, chromosome, chromosome, telomeric region, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q505G8
Entrez ID: 622675
|
Does Knockout of Tcaf3 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Tcaf3
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tcaf3 (TRPM8 channel-associated factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein binding, transmembrane transporter binding
Pathways:
UniProt: Q6QR59
Entrez ID: 403088
|
Does Knockout of Stpg4 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Stpg4
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Stpg4 (sperm tail PG rich repeat containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, epigenetic programing of male pronucleus, pyrimidine-containing compound catabolic process; MF: chromatin binding, histone binding, protein binding; CC: cytoplasm, female germ cell nucleus, female pronucleus, germinal vesicle, male germ cell nucleus, male pronucleus, nucleoplasm, nucleus
Pathways:
UniProt: Q9DAG5
Entrez ID: 75467
|
Does Knockout of Fignl1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Fignl1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Fignl1 (fidgetin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, cellular response to ionizing radiation, male meiotic nuclear division, microtubule severing, negative regulation of apoptotic process, negative regulation of intrinsic apoptotic signaling pathway, osteoblast differentiation, osteoblast proliferation, regulation of cell cycle, regulation of double-strand break repair via homologous recombination; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, magnesium ion binding, metal ion binding, microtubule severing ATPase activity, nucleotide binding; CC: cytoplasm, nuclear chromosome, nucleus, perinuclear region of cytoplasm
Pathways: Cell Cycle, DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Meiosis, Meiotic recombination, Reproduction, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q8BPY9
Entrez ID: 60530
|
Does Knockout of Zfp239 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Zfp239
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Zfp239 (zinc finger protein 239)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF239 (zinc finger protein 239). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, transcription cis-regulatory region binding, zinc ion binding
Pathways:
UniProt: P24399
Entrez ID: 22685
|
Does Knockout of Ptgdr2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Ptgdr2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ptgdr2 (prostaglandin D2 receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, calcium-mediated signaling, chemotaxis, negative regulation of male germ cell proliferation, neuropeptide signaling pathway, positive regulation of G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, icosanoid receptor activity, neuropeptide binding, prostaglandin D receptor activity, prostaglandin F receptor activity, prostaglandin J receptor activity; CC: membrane, neuron projection, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Prostanoid ligand receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9Z2J6
Entrez ID: 14764
|
Does Knockout of Ybx2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Ybx2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ybx2 (Y box protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA stabilization, negative regulation of RNA metabolic process, negative regulation of macromolecule biosynthetic process, negative regulation of translation, oogenesis, positive regulation of cold-induced thermogenesis, regulation of gene expression, spermatid development; MF: DNA binding, RNA binding, chromatin binding, lipid binding, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding, ribonucleoprotein complex binding, translation regulator activity; CC: cytoplasm, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q497N3, B2RUF0, A0A0A0MQD2, Q3TTC8, J3QNB9
Entrez ID: 53422
|
Does Knockout of Hgsnat in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Hgsnat
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Hgsnat (heparan-alpha-glucosaminide N-acetyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heparan sulfate proteoglycan catabolic process, lysosomal transport, protein complex oligomerization; MF: acyltransferase activity, heparan-alpha-glucosaminide N-acetyltransferase activity, transferase activity; CC: lysosomal lumen, lysosomal membrane, lysosome, membrane
Pathways: Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG degradation, Heparan sulfate/heparin (HS-GAG) metabolism, Immune System, Innate Immune System, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation
UniProt: Q3UDW8
Entrez ID: 52120
|
Does Knockout of Slc50a1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Slc50a1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc50a1 (solute carrier family 50 (sugar transporter), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate transmembrane transport, carbohydrate transport, glucoside transport; MF: glucoside transmembrane transporter activity, sugar transmembrane transporter activity; CC: Golgi apparatus, Golgi membrane, endomembrane system, membrane, plasma membrane
Pathways: Cellular hexose transport, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q9CXK4
Entrez ID: 19729
|
Does Knockout of Fxyd6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Fxyd6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fxyd6 (FXYD domain-containing ion transport regulator 6)
Type: protein-coding
Summary: This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, Fxyd6, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Jul 2006].
Gene Ontology: BP: monoatomic ion transport, positive regulation of sodium ion export across plasma membrane, potassium ion transport, regulation of monoatomic ion transport, sodium ion transport; MF: ion channel regulator activity, sodium channel regulator activity; CC: glutamatergic synapse, membrane, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways: Cardiac conduction, Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Muscle contraction, Transport of small molecules
UniProt: Q9D164
Entrez ID: 59095
|
Does Knockout of Cyb5d2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Cyb5d2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Cyb5d2 (cytochrome b5 domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development, positive regulation of neuron differentiation; CC: endomembrane system, extracellular region, membrane
Pathways:
UniProt: Q5SSH8
Entrez ID: 192986
|
Does Knockout of Chic2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Chic2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Chic2 (cysteine-rich hydrophobic domain 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, Golgi-associated vesicle, membrane, plasma membrane
Pathways:
UniProt: Q9D9G3
Entrez ID: 74277
|
Does Knockout of Tnfrsf9 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Tnfrsf9
|
cell proliferation
|
Regulatory T cell
|
Gene: Tnfrsf9 (tumor necrosis factor receptor superfamily, member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of cell population proliferation, regulation of cell population proliferation, regulation of immature T cell proliferation in thymus; MF: protein binding, signaling receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, TNFR2 non-canonical NF-kB pathway, TNFs bind their physiological receptors
UniProt: P20334
Entrez ID: 21942
|
Does Knockout of Ndufa13 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,285
|
Knockout
|
Ndufa13
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ndufa13 (NADH:ubiquinone oxidoreductase subunit A13)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in mitochondrion and nucleus. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; heart; and oocyte. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 28 and oncocytic carcinoma of the thyroid. Orthologous to human NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: aerobic respiration, apoptotic process, cellular response to interferon-beta, cellular response to retinoic acid, extrinsic apoptotic signaling pathway, mitochondrial respiratory chain complex I assembly, negative regulation of DNA-templated transcription, positive regulation of execution phase of apoptosis, positive regulation of protein catabolic process, protein insertion into mitochondrial inner membrane, proton motive force-driven mitochondrial ATP synthesis; CC: cytoplasm, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm, nucleus, respiratory chain complex, respiratory chain complex I, synapse
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9ERS2
Entrez ID: 67184
|
Does Knockout of Prc1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Prc1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Prc1 (protein regulator of cytokinesis 1)
Type: protein-coding
Summary: Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell population proliferation; and regulation of cytokinesis. Predicted to act upstream of or within microtubule bundle formation. Predicted to be located in several cellular components, including contractile ring; intercellular bridge; and midbody. Predicted to be active in cytoplasm and mitotic spindle midzone. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, microtubule cytoskeleton organization, mitotic spindle midzone assembly, positive regulation of cell population proliferation, regulation of cytokinesis; MF: identical protein binding, kinesin binding, microtubule binding, protein kinase binding; CC: contractile ring, cytoplasm, cytoskeleton, intercellular bridge, microtubule, microtubule cytoskeleton, midbody, mitotic spindle midzone, nucleoplasm, nucleus, plasma membrane, spindle, spindle pole
Pathways: RHO GTPase Effectors, RHO GTPases activate CIT, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q99K43
Entrez ID: 233406
|
Does Knockout of Atp13a1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Atp13a1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atp13a1 (ATPase type 13A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extraction of mislocalized protein from ER membrane, intracellular calcium ion homeostasis, monoatomic cation transmembrane transport, protein transport, transmembrane transport; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled monoatomic cation transmembrane transporter activity, P-type ion transporter activity, P-type transmembrane transporter activity, membrane protein dislocase activity, metal ion binding, nucleotide binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: Q9EPE9
Entrez ID: 170759
|
Does Knockout of Slc12a6 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Slc12a6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc12a6 (solute carrier family 12, member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell volume homeostasis, cellular hypotonic response, cellular hypotonic salinity response, cellular response to glucose stimulus, chemical synaptic transmission, chloride ion homeostasis, chloride transmembrane transport, monoatomic ion transport, potassium ion homeostasis, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, transmembrane transport; MF: chloride:monoatomic cation symporter activity, metal ion binding, potassium ion transmembrane transporter activity, potassium:chloride symporter activity, protein binding, protein kinase binding, symporter activity, transmembrane transporter activity; CC: axon, basolateral plasma membrane, membrane, plasma membrane, synapse
Pathways: Cation-coupled Chloride cotransporters, SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Transport of small molecules
UniProt: Q924N4
Entrez ID: 107723
|
Does Knockout of Lpar1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Lpar1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lpar1 (lysophosphatidic acid receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Golgi to plasma membrane protein transport, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, bleb assembly, cell chemotaxis, cellular response to 1-oleoyl-sn-glycerol 3-phosphate, cellular response to oxygen levels, cerebellum development, corpus callosum development, myelination, negative regulation of cAMP/PKA signal transduction, negative regulation of cilium assembly, negative regulation of neuron projection development, neurogenesis, oligodendrocyte development, optic nerve development, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of Rho protein signal transduction, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cilium assembly, positive regulation of dendritic spine development, positive regulation of smooth muscle cell chemotaxis, positive regulation of stress fiber assembly, protein localization to cilium, regulation of cell shape, regulation of postsynaptic neurotransmitter receptor internalization, regulation of synaptic vesicle cycle, regulation of vesicle-mediated transport, signal transduction; MF: G protein-coupled receptor activity, G-protein alpha-subunit binding, PDZ domain binding, lysophosphatidic acid binding, lysophosphatidic acid receptor activity, phospholipid binding, protein binding; CC: GABA-ergic synapse, cell surface, cytoplasm, dendritic shaft, dendritic spine, endocytic vesicle, endosome, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Gap junction - Mus musculus (mouse), Lysosphingolipid and LPA receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P61793
Entrez ID: 14745
|
Does Knockout of Adora2b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Adora2b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Adora2b (adenosine A2b receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled adenosine receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, negative regulation of cell population proliferation, negative regulation of collagen biosynthetic process, positive regulation of cAMP/PKA signal transduction, positive regulation of cGMP-mediated signaling, positive regulation of catecholamine secretion, positive regulation of cell population proliferation, positive regulation of chemokine production, positive regulation of chronic inflammatory response to non-antigenic stimulus, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of interleukin-6 production, positive regulation of mast cell degranulation, positive regulation of norepinephrine secretion, positive regulation of steroid biosynthetic process, positive regulation of vascular endothelial growth factor production, presynaptic modulation of chemical synaptic transmission, regulation of cell communication, regulation of glucose metabolic process, regulation of signaling, relaxation of vascular associated smooth muscle, response to angiotensin, signal transduction, vasodilation; MF: G protein-coupled adenosine receptor activity, G protein-coupled receptor activity; CC: Schaffer collateral - CA1 synapse, cell surface, glutamatergic synapse, membrane, plasma membrane, presynapse, synapse
Pathways: Adenosine P1 receptors, Alcoholism - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Metabolism of proteins, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nucleotide-like (purinergic) receptors, Rap1 signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Surfactant metabolism, Vascular smooth muscle contraction - Mus musculus (mouse)
UniProt: Q60614
Entrez ID: 11541
|
Does Knockout of Gm5458 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm5458
|
phagocytosis
|
macrophage
|
Gene: Gm5458 (predicted gene 5458)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6P8Z5, L7N219
Entrez ID: 432825
|
Does Knockout of Zfp945 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Zfp945
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp945 (zinc finger protein 945)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, transcription cis-regulatory region binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: F6WAU7, Q66L36, Q3TGT7
Entrez ID: 240041
|
Does Knockout of Mrps18c in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Mrps18c
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mrps18c (mitochondrial ribosomal protein S18C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q8R2L5
Entrez ID: 68735
|
Does Knockout of Naa11 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Naa11
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Naa11 (N(alpha)-acetyltransferase 11, NatA catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: N-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, protein N-terminal-serine acetyltransferase activity, protein-N-terminal amino-acid acetyltransferase activity, protein-N-terminal-alanine acetyltransferase activity, protein-N-terminal-glutamate acetyltransferase activity, transferase activity; CC: Golgi apparatus, NatA complex, centrosome, ciliary basal body, cilium, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q3UX61
Entrez ID: 97243
|
Does Knockout of Cdk5rap3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Cdk5rap3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cdk5rap3 (CDK5 regulatory subunit associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic nuclear changes, cell population proliferation, definitive erythrocyte differentiation, endoplasmic reticulum unfolded protein response, liver development, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, negative regulation of MAP kinase activity, negative regulation of NF-kappaB transcription factor activity, negative regulation of protein catabolic process, negative regulation of protein kinase activity by regulation of protein phosphorylation, negative regulation of protein phosphorylation, negative regulation of protein serine/threonine kinase activity, positive regulation of protein localization to nucleus, positive regulation of protein ubiquitination, positive regulation of proteolysis involved in protein catabolic process, positive regulation of reticulophagy, positive regulation of signal transduction by p53 class mediator, positive regulation of transcription by RNA polymerase II, positive regulation of ubiquitin-dependent protein catabolic process, protein ufmylation, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of mitotic cell cycle, regulation of phosphatase activity, rescue of stalled ribosome, response to endoplasmic reticulum stress, ribosome disassembly; MF: MDM2/MDM4 family protein binding, NF-kappaB binding, cyclin binding, mitogen-activated protein kinase binding, protein binding, protein kinase binding, protein-containing complex binding, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-like protein ligase binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, microtubule, nucleolus, nucleus, protein-containing complex
Pathways:
UniProt: Q99LM2
Entrez ID: 80280
|
Does Knockout of Yy1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,559
|
Knockout
|
Yy1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Yy1 (YY1 transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, DNA damage response, DNA recombination, DNA repair, RNA localization, anterior/posterior pattern specification, camera-type eye morphogenesis, cell differentiation, cellular response to UV, cellular response to interleukin-1, chromatin remodeling, chromosome organization, double-strand break repair via homologous recombination, gene expression, hemopoiesis, immunoglobulin heavy chain V-D-J recombination, negative regulation of cell growth involved in cardiac muscle cell development, negative regulation of gene expression, negative regulation of interferon-beta production, negative regulation of miRNA transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, regulation of transcription by RNA polymerase II, response to UV-C, response to prostaglandin F, spermatogenesis, telomere maintenance; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SMAD binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, four-way junction DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: Ino80 complex, PcG protein complex, chromatin, chromatin silencing complex, cytoplasm, nuclear matrix, nucleoplasm, nucleus, transcription regulator complex
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q00899
Entrez ID: 22632
|
Does Knockout of Gria2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Gria2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Gria2 (glutamate receptor, ionotropic, AMPA2 (alpha 2))
Type: protein-coding
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to brain-derived neurotrophic factor stimulus, cellular response to glycine, chemical synaptic transmission, conditioned place preference, establishment of protein localization, excitatory postsynaptic potential, ionotropic glutamate receptor signaling pathway, modulation of chemical synaptic transmission, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of synaptic transmission, protein tetramerization, receptor internalization, regulation of long-term synaptic depression, regulation of postsynaptic membrane potential, regulation of receptor recycling, regulation of synaptic transmission, glutamatergic, synaptic transmission, glutamatergic; MF: AMPA glutamate receptor activity, PDZ domain binding, SNARE binding, amyloid-beta binding, cytoskeletal protein binding, extracellular ligand-gated monoatomic ion channel activity, extracellularly glutamate-gated ion channel activity, glutamate receptor binding, glutamate-gated calcium ion channel activity, glutamate-gated receptor activity, identical protein binding, immunoglobulin binding, ionotropic glutamate receptor binding, kainate selective glutamate receptor activity, ligand-gated monoatomic cation channel activity, ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, monoatomic ion channel activity, protein binding, protein kinase binding, protein-containing complex binding, scaffold protein binding, signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: AMPA glutamate receptor complex, Schaffer collateral - CA1 synapse, asymmetric synapse, axon, cell surface, dendrite, dendrite cytoplasm, dendrite membrane, dendritic shaft, dendritic spine, dendritic spine head, dendritic spine neck, endoplasmic reticulum, external side of plasma membrane, glutamatergic synapse, growth cone, membrane, neuron projection, neuronal cell body, perikaryon, perisynaptic space, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, presynapse, presynaptic active zone membrane, presynaptic membrane, protein-containing complex, somatodendritic compartment, spine synapse, synapse, synaptic membrane, synaptic vesicle, synaptic vesicle membrane, terminal bouton
Pathways: Amphetamine addiction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nicotine addiction - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q4LG64, E9QKC0, G5E8H1, A0A0A6YW90
Entrez ID: 14800
|
Does Knockout of Mettl13 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Mettl13
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mettl13 (methyltransferase 13, eEF1A lysine and N-terminal methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: catalytic activity, methyltransferase activity, molecular_function, protein-lysine N-methyltransferase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion, nucleus
Pathways:
UniProt: Q91YR5
Entrez ID: 71449
|
Does Knockout of Klra21 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Klra21
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Klra21 (killer cell lectin-like receptor subfamily A, member 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9JHV1
Entrez ID: 93968
|
Does Knockout of Itga11 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Itga11
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Itga11 (integrin alpha 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell adhesion mediated by integrin, cell-cell adhesion, cell-matrix adhesion, collagen-activated signaling pathway, fibroblast migration, integrin-mediated signaling pathway, substrate-dependent cell migration; MF: collagen binding, collagen binding involved in cell-matrix adhesion, collagen receptor activity, metal ion binding, signaling receptor activity; CC: cell surface, focal adhesion, integrin alpha11-beta1 complex, integrin complex, membrane
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), ECM-receptor interaction - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse)
UniProt: Q8CE84, Q7TQC3, A0A0B4J1F0
Entrez ID: 319480
|
Does Knockout of Riok3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Riok3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Riok3 (RIO kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to dsDNA, cellular response to dsRNA, cellular response to virus, defense response to virus, immune system process, innate immune response, maturation of SSU-rRNA, negative regulation of MDA-5 signaling pathway, negative regulation of canonical NF-kappaB signal transduction, negative regulation of protein-containing complex assembly, positive regulation of innate immune response, positive regulation of interferon-beta production, ribosome biogenesis; MF: ATP binding, caspase binding, catalytic activity, kinase activity, metal ion binding, nucleotide binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9DBU3
Entrez ID: 66878
|
Does Knockout of Fam47c in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Fam47c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fam47c (family with sequence similarity 47, member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, transcription initiation-coupled chromatin remodeling; CC: cellular_component, chromatin
Pathways:
UniProt: Q14BE7
Entrez ID: 70864
|
Does Knockout of Cplx3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Cplx3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cplx3 (complexin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, insulin secretion, modulation of chemical synaptic transmission, neurotransmitter transport, regulation of neurotransmitter secretion, regulation of synaptic vesicle fusion to presynaptic active zone membrane, synaptic vesicle exocytosis, synaptic vesicle tethering involved in synaptic vesicle exocytosis, visual perception; MF: SNARE binding, neurotransmitter transmembrane transporter activity, syntaxin binding; CC: SNARE complex, cytosol, membrane, photoreceptor ribbon synapse, plasma membrane, presynaptic active zone membrane, synapse, synaptic vesicle membrane, terminal bouton
Pathways: Synaptic vesicle cycle - Mus musculus (mouse)
UniProt: Q8R1B5
Entrez ID: 235415
|
Does Knockout of Mgat4a in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Mgat4a
|
phagocytosis
|
macrophage
|
Gene: Mgat4a (mannoside acetylglucosaminyltransferase 4, isoenzyme A)
Type: protein-coding
Summary: Enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Involved in N-glycan processing. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in peroxisome. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: N-glycan processing, glyoxylate metabolic process, protein N-linked glycosylation, protein glycosylation; MF: acetylglucosaminyltransferase activity, alanine-glyoxylate transaminase activity, alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity, glycosyltransferase activity, metal ion binding, protein homodimerization activity, transferase activity; CC: Golgi apparatus, Golgi membrane, Golgi stack, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, extracellular region, membrane, peroxisome
Pathways: Asparagine N-linked glycosylation, Metabolism of proteins, N-Glycan antennae elongation, N-Glycan biosynthesis - Mus musculus (mouse), N-glycan antennae elongation in the medial/trans-Golgi, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Transport to the Golgi and subsequent modification, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q812G0
Entrez ID: 269181
|
Does Knockout of Lemd1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Lemd1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Lemd1 (LEM domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q14C37
Entrez ID: 213409
|
Does Knockout of Cpa5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Cpa5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cpa5 (carboxypeptidase A5)
Type: protein-coding
Summary: This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed in mouse testes where the encoded protein is localized to the germ cells. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: proteolysis; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8R4H4
Entrez ID: 74649
|
Does Knockout of St3gal4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
St3gal4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: St3gal4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cognition, glycolipid biosynthetic process, glycoprotein biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, positive regulation of blood coagulation, positive regulation of leukocyte tethering or rolling, protein glycosylation, sialylation; MF: N-acetyllactosaminide alpha-2,3-sialyltransferase activity, beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase, beta-galactoside (CMP) alpha-2,3-sialyltransferase activity, glycosyltransferase activity, sialyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Blood group systems biosynthesis, Glycosaminoglycan metabolism, Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, N-Glycan antennae elongation, N-glycan antennae elongation in the medial/trans-Golgi, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis, Termination of O-glycan biosynthesis, Transport to the Golgi and subsequent modification
UniProt: Q91Y74
Entrez ID: 20443
|
Does Knockout of Psors1c2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Psors1c2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Psors1c2 (psoriasis susceptibility 1 candidate 2 (human))
Type: protein-coding
Summary: Predicted to be located in extracellular region. Orthologous to human PSORS1C2 (psoriasis susceptibility 1 candidate 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: Q80ZC9
Entrez ID: 57390
|
Does Knockout of Try5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Try5
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Try5 (trypsin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: calcium ion binding, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: acrosomal vesicle, cytoplasmic vesicle, extracellular region, extracellular space
Pathways: Activation of Matrix Metalloproteinases, Alpha-defensins, Antimicrobial peptides, Defensins, Degradation of the extracellular matrix, Extracellular matrix organization, Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neutrophil degranulation, Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q9QUK9
Entrez ID: 103964
|
Does Knockout of Trim14 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Trim14
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Trim14 (tripartite motif-containing 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, inflammatory response, innate immune response, negative regulation of viral transcription, positive regulation of DNA-templated transcription, protein K48-linked deubiquitination; MF: metal ion binding, molecular adaptor activity, transcription coactivator activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, membrane, mitochondrial outer membrane, mitochondrion, phagocytic vesicle
Pathways:
UniProt: Q8BVW3
Entrez ID: 74735
|
Does Knockout of Cib1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Cib1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cib1 (calcium and integrin binding 1)
Type: protein-coding
Summary: Enables protein-membrane adaptor activity and transmembrane transporter binding activity. Involved in several processes, including negative regulation of megakaryocyte differentiation; regulation of intracellular signal transduction; and regulation of protein phosphorylation. Located in cytoplasm and sarcolemma. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human CIB1 (calcium and integrin binding 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA damage response, angiogenesis, apoptotic process, cell adhesion, cell differentiation, cell division, cellular response to growth factor stimulus, cellular response to nerve growth factor stimulus, cellular response to tumor necrosis factor, cytoplasmic microtubule organization, endomitotic cell cycle, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of megakaryocyte differentiation, negative regulation of microtubule depolymerization, negative regulation of neuron projection development, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of protein phosphorylation, platelet formation, positive regulation of ERK1 and ERK2 cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of catalytic activity, positive regulation of cell adhesion mediated by integrin, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cell population proliferation, positive regulation of cell-matrix adhesion, positive regulation of male germ cell proliferation, positive regulation of protein localization to plasma membrane, positive regulation of protein phosphorylation, positive regulation of protein serine/threonine kinase activity, positive regulation of protein targeting to membrane, positive regulation of substrate adhesion-dependent cell spreading, regulation of cell division, regulation of cell population proliferation, response to ischemia, spermatid development, spermatogenesis, thrombopoietin-mediated signaling pathway; MF: calcium ion binding, calcium-dependent protein kinase inhibitor activity, magnesium ion binding, metal ion binding, protein binding, protein kinase binding, protein serine/threonine kinase inhibitor activity, protein-membrane adaptor activity, small GTPase binding, transmembrane transporter binding; CC: apical plasma membrane, axon, cell periphery, cell projection, centrosome, cytoplasm, cytoskeleton, dendrite, endoplasmic reticulum, filopodium tip, growth cone, lamellipodium, membrane, neuron projection, neuronal cell body, nuclear body, nucleoplasm, nucleus, perikaryon, perinuclear region of cytoplasm, plasma membrane, ruffle membrane, sarcolemma
Pathways:
UniProt: Q9Z0F4
Entrez ID: 23991
|
Does Knockout of Lrrc8c in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Lrrc8c
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Lrrc8c (leucine rich repeat containing 8 family, member C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aspartate transmembrane transport, cellular response to osmotic stress, cyclic-GMP-AMP transmembrane import across plasma membrane, fat cell differentiation, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, protein hexamerization, taurine transmembrane transport, transmembrane transport; MF: volume-sensitive anion channel activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, monoatomic ion channel complex, plasma membrane
Pathways: Miscellaneous transport and binding events, Transport of small molecules
UniProt: Q8R502
Entrez ID: 100604
|
Does Knockout of Lpp in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Lpp
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lpp (LIM domain containing preferred translocation partner in lipoma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion; MF: metal ion binding, protein binding; CC: anchoring junction, cytoplasm, cytosol, focal adhesion, nucleus, plasma membrane, stress fiber
Pathways:
UniProt: Q8BFW7
Entrez ID: 210126
|
Does Knockout of Qpctl in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Qpctl
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Qpctl (glutaminyl-peptide cyclotransferase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acyltransferase activity, glutaminyl-peptide cyclotransferase activity, metal ion binding, transferase activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, membrane
Pathways:
UniProt: Q8BH73
Entrez ID: 67369
|
Does Knockout of Prr16 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Prr16
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prr16 (proline rich 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell size, positive regulation of translation
Pathways:
UniProt: A3KMN5
Entrez ID: 71373
|
Does Knockout of Srgap3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Srgap3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Srgap3 (SLIT-ROBO Rho GTPase activating protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell migration, nervous system development, regulation of postsynapse assembly, regulation of synapse assembly, signal transduction; MF: GTPase activator activity, protein binding; CC: glutamatergic synapse, postsynapse, synapse
Pathways: Axon guidance - Mus musculus (mouse), CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q812A2
Entrez ID: 259302
|
Does Knockout of Ppp1r10 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Ppp1r10
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Ppp1r10 (protein phosphatase 1, regulatory subunit 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, negative regulation of cardiac muscle cell apoptotic process, negative regulation of mitotic DNA damage checkpoint, negative regulation of transcription elongation by RNA polymerase II, positive regulation of telomere maintenance, positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled, positive regulation of transcription elongation by RNA polymerase II, protein stabilization, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: DNA binding, RNA binding, enzyme-substrate adaptor activity, metal ion binding, protein binding, protein phosphatase 1 binding, protein phosphatase inhibitor activity, protein phosphatase regulator activity, zinc ion binding; CC: PTW/PP1 phosphatase complex, chromatin, chromosome, chromosome, telomeric region, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q80W00
Entrez ID: 52040
|
Does Knockout of Nploc4 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Nploc4
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Nploc4 (NPL4 homolog, ubiquitin recognition factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, Golgi organization, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, proteasome-mediated ubiquitin-dependent protein catabolic process, retrograde protein transport, ER to cytosol, ubiquitin-dependent protein catabolic process; MF: ATPase binding, K48-linked polyubiquitin modification-dependent protein binding, K63-linked polyubiquitin modification-dependent protein binding, metal ion binding, protein-containing complex binding, ubiquitin binding, ubiquitin protein ligase binding, zinc ion binding; CC: UFD1-NPL4 complex, VCP-NPL4-UFD1 AAA ATPase complex, cytoplasm, cytosol, endoplasmic reticulum, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, DNA Damage Bypass, DNA Repair, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P60670
Entrez ID: 217365
|
Does Knockout of Trav5-1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Trav5-1
|
phagocytosis
|
macrophage
|
Gene: Trav5-1 (T cell receptor alpha variable 5-1)
Type: other
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune system process, response to bacterium
Pathways:
UniProt:
Entrez ID: 633740
|
Does Knockout of Nup205 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,683
|
Knockout
|
Nup205
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nup205 (nucleoporin 205)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport; MF: structural constituent of nuclear pore; CC: nuclear envelope, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q6P9L5, B9EJ54, Q6PDG0, A0A0J9YUD5
Entrez ID: 70699
|
Does Knockout of Bmp7 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Bmp7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Bmp7 (bone morphogenetic protein 7)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutation of this gene results in skeletal, kidney, and other developmental defects. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: BMP signaling pathway, allantois development, ameloblast differentiation, anatomical structure formation involved in morphogenesis, animal organ morphogenesis, axon guidance, branching involved in salivary gland morphogenesis, branching morphogenesis of an epithelial tube, camera-type eye morphogenesis, cardiac muscle tissue development, cardiac septum morphogenesis, cartilage development, cell development, cell differentiation, cell-cell adhesion, cellular response to BMP stimulus, chorio-allantoic fusion, embryonic camera-type eye morphogenesis, embryonic limb morphogenesis, embryonic pattern specification, embryonic skeletal joint morphogenesis, endocardial cushion formation, epithelial cell differentiation, eye development, heart development, heart trabecula morphogenesis, hindbrain development, kidney development, mesenchymal cell differentiation, mesenchyme development, mesoderm formation, mesonephros development, metanephric mesenchymal cell proliferation involved in metanephros development, metanephric mesenchyme morphogenesis, metanephros development, monocyte aggregation, negative regulation of DNA-templated transcription, negative regulation of Notch signaling pathway, negative regulation of cell cycle, negative regulation of cell population proliferation, negative regulation of glomerular mesangial cell proliferation, negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis, negative regulation of mitotic nuclear division, negative regulation of neurogenesis, negative regulation of neuron differentiation, negative regulation of prostatic bud formation, nephrogenic mesenchyme morphogenesis, neural fold elevation formation, neuron projection morphogenesis, odontogenesis of dentin-containing tooth, ossification, osteoblast differentiation, pattern specification process, pericardium morphogenesis, pharyngeal system development, positive regulation of DNA-templated transcription, positive regulation of SMAD protein signal transduction, positive regulation of apoptotic process, positive regulation of bone mineralization, positive regulation of brown fat cell differentiation, positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis, positive regulation of cell differentiation, positive regulation of dendrite development, positive regulation of epithelial cell differentiation, positive regulation of epithelial to mesenchymal transition, positive regulation of gene expression, positive regulation of heterotypic cell-cell adhesion, positive regulation of hyaluranon cable assembly, positive regulation of multicellular organismal process, positive regulation of neuron differentiation, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, regulation of branching involved in prostate gland morphogenesis, regulation of multicellular organismal development, regulation of signal transduction, response to estradiol, response to peptide hormone, response to vitamin D, salivary gland morphogenesis, skeletal system development, tube morphogenesis, ureteric bud development; MF: BMP receptor binding, cytokine activity, growth factor activity, heparin binding, protein binding, protein serine/threonine kinase activator activity, receptor ligand activity; CC: extracellular matrix, extracellular region, extracellular space, vesicle
Pathways: Axon guidance - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Elastic fibre formation, Extracellular matrix organization, Hippo signaling pathway - Mus musculus (mouse), Molecules associated with elastic fibres, TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: P23359
Entrez ID: 12162
|
Does Knockout of Amer2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Amer2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Amer2 (APC membrane recruitment 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, ectoderm development, negative regulation of canonical Wnt signaling pathway, regulation of canonical Wnt signaling pathway; MF: beta-catenin binding, lipid binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8CCJ4
Entrez ID: 72125
|
Does Knockout of Arl6ip5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Arl6ip5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Arl6ip5 (ADP-ribosylation factor-like 6 interacting protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate import across plasma membrane, L-glutamate transmembrane transport, cellular response to oxidative stress, glutathione metabolic process, intrinsic apoptotic signaling pathway in response to oxidative stress, learning or memory, negative regulation of L-glutamate import across plasma membrane, negative regulation of mitochondrial membrane potential, negative regulation of transport, positive regulation of apoptotic process, positive regulation of stress-activated MAPK cascade, protein localization to plasma membrane, protein transport, regulation of neurotransmitter uptake; MF: protein binding, transmembrane transporter binding; CC: cytoplasm, cytoskeleton, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane, presynaptic cytosol
Pathways: Glutamate Neurotransmitter Release Cycle, Neuronal System, Neurotransmitter release cycle, Transmission across Chemical Synapses
UniProt: Q8R5J9
Entrez ID: 65106
|
Does Knockout of Ctsl in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Ctsl
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Ctsl (cathepsin L)
Type: protein-coding
Summary: This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and the cathepsin L1 heavy and light chains. The mature enzyme appears to be important in embryonic development through its processing of histone H3 and may play a role in disease progression in a model of kidney disease. Homozygous knockout mice for this gene exhibit hair loss, skin thickening, bone and heart defects, and enhanced susceptibility to bacterial infection. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: CD4-positive, alpha-beta T cell lineage commitment, Sertoli cell differentiation, antigen processing and presentation of peptide antigen, autophagic cell death, cellular response to starvation, collagen catabolic process, decidualization, elastin catabolic process, enkephalin processing, epithelial tube branching involved in lung morphogenesis, hair follicle morphogenesis, heparan sulfate proteoglycan catabolic process, male gonad development, negative regulation of keratinocyte proliferation, nerve development, protein autoprocessing, protein catabolic process, proteolysis, proteolysis involved in protein catabolic process, response to glucocorticoid, response to glucose, response to gonadotropin, spermatogenesis, thyroid hormone generation, zymogen activation; MF: aminopeptidase activity, collagen binding, cysteine-type carboxypeptidase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, endopeptidase activity, fibronectin binding, histone binding, hydrolase activity, kininogen binding, metal ion binding, peptidase activity, peptide binding, protein binding, protein-containing complex binding, proteoglycan binding, serpin family protein binding; CC: Golgi apparatus, apical part of cell, apical plasma membrane, chromaffin granule, cytoplasm, cytoplasmic vesicle, external side of plasma membrane, extracellular matrix, extracellular region, extracellular space, lysosome, membrane, microvillus, multivesicular body, nucleolus, nucleus, perikaryon, plasma membrane, secretory granule
Pathways: Activation of Matrix Metalloproteinases, Adaptive Immune System, Antigen processing and presentation - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Assembly of collagen fibrils and other multimeric structures, Autophagy - animal - Mus musculus (mouse), Collagen formation, Degradation of the extracellular matrix, Extracellular matrix organization, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Lysosome - Mus musculus (mouse), MHC class II antigen presentation, Phagosome - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of keratinocytes, Rheumatoid arthritis - Mus musculus (mouse), Toll-like Receptor Cascades, Trafficking and processing of endosomal TLR, Transcriptional regulation by RUNX1
UniProt: P06797
Entrez ID: 13039
|
Does Knockout of Calhm1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Calhm1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Calhm1 (calcium homeostasis modulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP export, ATP transport, calcium ion transmembrane transport, calcium ion transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, protein heterooligomerization, protein homooligomerization, regulation of monoatomic ion transmembrane transport, sensory perception of bitter taste, sensory perception of sweet taste, sensory perception of taste, sensory perception of umami taste; MF: calcium channel activity, calcium-activated cation channel activity, identical protein binding, monoatomic cation channel activity, voltage-gated calcium channel activity, voltage-gated channel activity, voltage-gated monoatomic ion channel activity; CC: basolateral plasma membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane, plasma membrane raft
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: D3Z291
Entrez ID: 546729
|
Does Knockout of Med23 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Med23
|
response to virus
|
Microglial Cell Line
|
Gene: Med23 (mediator complex subunit 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of T cell extravasation, positive regulation of gene expression, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, transcription regulator complex, ubiquitin ligase complex
Pathways:
UniProt: Q80YQ2
Entrez ID: 70208
|
Does Knockout of Api5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Api5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Api5 (apoptosis inhibitor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, negative regulation of fibroblast apoptotic process; MF: RNA binding, fibroblast growth factor binding; CC: cytoplasm, nuclear speck, nucleus, spliceosomal complex
Pathways:
UniProt: O35841
Entrez ID: 11800
|
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