prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Grik1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Grik1 | protein/peptide distribution | myoblast cell line | Gene: Grik1 (glutamate receptor, ionotropic, kainate 1)
Type: protein-coding
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family ... |
Does Knockout of Med8 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Med8 | response to virus | Microglial Cell Line | Gene: Med8 (mediator complex subunit 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymeras... |
Does Knockout of Tmem53 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Tmem53 | cell proliferation | Melanoma Cell Line | Gene: Tmem53 (transmembrane protein 53)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of BMP signaling pathway, negative regulation of ossification, negative regulation of osteoblast differentiation, regulation of nucleocytoplasmi... |
Does Knockout of Mfsd4b5 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,684 | Knockout | Mfsd4b5 | protein/peptide distribution | myoblast cell line | Gene: Mfsd4b5 (major facilitator superfamily domain containing 4B5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import across plasma membrane, monoatomic ion transport, sodium ion transport, transmembrane transport; MF: symporter activity, transmembrane tran... |
Does Knockout of Add2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Add2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Add2 (adducin 2)
Type: protein-coding
Summary: This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain ... |
Does Knockout of Mir467c in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Mir467c | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Mir467c (microRNA 467c)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of Elk4 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Elk4 | cell cycle progression | breast epithelium | Gene: Elk4 (ELK4, member of ETS oncogene family)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be inv... |
Does Knockout of Fbxo33 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Fbxo33 | cell proliferation | Colonic Cancer Cell Line | Gene: Fbxo33 (F-box protein 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein ubiquitination, protein ubiquitination
Pathways:
UniProt: Q8VE08
Entrez ID: 70611 |
Does Knockout of Pou1f1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 163 | Knockout | Pou1f1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Pou1f1 (POU domain, class 1, transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, adenohypophysis development, cell fate specification, determination of adult lifespan, negative regulation of transcription by RNA polymerase... |
Does Knockout of Rnaseh2c in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Rnaseh2c | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Rnaseh2c (ribonuclease H2, subunit C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, mismatch repair; CC: nucleus, ribonuclease H2 complex
Pathways: DNA replication - Mus musculus (mouse)
UniProt: Q9CQ18
Entrez ID: 6... |
Does Knockout of Prmt3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Prmt3 | protein/peptide distribution | myoblast cell line | Gene: Prmt3 (protein arginine N-methyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, dendritic spine morphogenesis, methylation, negative regulation of protein ubiquitination, negative regulation of retinoic acid biosynthetic process,... |
Does Knockout of Gab2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Gab2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Gab2 (growth factor receptor bound protein 2-associated protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, cell surface receptor protein tyrosine kinase signaling pathway, integrin-mediated signaling pathway, intracellular signal transduction... |
Does Knockout of Ppm1d in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Ppm1d | cell proliferation | Colonic Cancer Cell Line | Gene: Ppm1d (protein phosphatase 1D magnesium-dependent, delta isoform)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, DNA methylation-dependent constitutive heterochromatin formation, G2/M transition of mit... |
Does Knockout of Prr5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Prr5 | cell proliferation | Colonic Cancer Cell Line | Gene: Prr5 (proline rich 5 (renal))
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of protein phosphorylation. Predicted to be part o... |
Does Knockout of Pigv in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Pigv | protein/peptide distribution | myoblast cell line | Gene: Pigv (phosphatidylinositol glycan anchor biosynthesis, class V)
Type: protein-coding
Summary: Predicted to enable mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be part of mannosyltransferase complex. Predicted to be active in endoplasmic re... |
Does Knockout of Gpr139 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Gpr139 | cell proliferation | Colonic Cancer Cell Line | Gene: Gpr139 (G protein-coupled receptor 139)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, signal transduction; MF: G ... |
Does Knockout of Terf2ip in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,541 | Knockout | Terf2ip | response to chemicals | Lymphoma Cell Line | Gene: Terf2ip (telomeric repeat binding factor 2, interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, negative regulation of DNA recombination at telomere, negative regulation of telomere maintenance, positive regulation... |
Does Knockout of Slc7a7 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Slc7a7 | response to bacteria | renal medulla cell line | Gene: Slc7a7 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-arginine transmembrane transport, L-leucine transport, amino acid transmembrane transport, amino acid transport, regulation of a... |
Does Knockout of Echdc1 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Echdc1 | protein/peptide accumulation | Regulatory T cell | Gene: Echdc1 (enoyl Coenzyme A hydratase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carboxy-lyase activity, catalytic activity, lyase activity, methyl/ethyl malonyl-CoA decarboxylase activity; CC: cytoplasm, cytosol
Pathways: Propanoate ... |
Does Knockout of Agtr2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Agtr2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Agtr2 (angiotensin II receptor, type 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger, angiotensin-activated signaling pathway, a... |
Does Knockout of Yaf2 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Yaf2 | protein/peptide accumulation | Mouse cell | Gene: Yaf2 (YY1 associated factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: DNA binding, metal ion binding, prot... |
Does Knockout of Mrpl14 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Mrpl14 | protein/peptide accumulation | Mouse cell | Gene: Mrpl14 (mitochondrial ribosomal protein L14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
... |
Does Knockout of A130010J15Rik in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | A130010J15Rik | protein/peptide distribution | myoblast cell line | Gene: A130010J15Rik (RIKEN cDNA A130010J15 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DAE8
Entrez ID: 319266 |
Does Knockout of Laptm5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Laptm5 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Laptm5 (lysosomal-associated protein transmembrane 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to lysosome transport, cellular response to leukemia inhibitory factor, defense response to tumor cell, induction of programmed cell death, intracellular prot... |
Does Knockout of Mamld1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Mamld1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Mamld1 (mastermind-like domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: male gonad development, regulation of transcription by RNA polymerase II, spermatid differentiation, spermatogenesis; CC: Golgi apparatus, centrosome, nuclear body, nucleopl... |
Does Knockout of Ptprf in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Ptprf | cell proliferation | Melanoma Cell Line | Gene: Ptprf (protein tyrosine phosphatase receptor type F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell migration, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of cell population proliferation, negative regula... |
Does Knockout of Rpe65 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Rpe65 | protein/peptide accumulation | Melanoma Cell Line | Gene: Rpe65 (retinal pigment epithelium 65)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye development, circadian rhythm, detection of light stimulus involved in visual perception, lipid metabolic process, neural retina development, response to light stim... |
Does Knockout of Lrrc4b in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Lrrc4b | protein/peptide accumulation | Embryonic Cell Line | Gene: Lrrc4b (leucine rich repeat containing 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of synapse assembly, regulation of postsynaptic density assembly, regulation of presynapse assembly, synaptic membrane adhesion; MF: cell-cell adhesion med... |
Does Knockout of Oplah in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 2,173 | Knockout | Oplah | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Oplah (5-oxoprolinase (ATP-hydrolysing))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutathione metabolic process; MF: 5-oxoprolinase (ATP-hydrolyzing) activity, ATP binding, catalytic activity, hydrolase activity, identical protein binding, nucleotide binding;... |
Does Knockout of Lag3 in Embryonic Fibroblast Cell Line causally result in autophagy? | 1 | 1,044 | Knockout | Lag3 | autophagy | Embryonic Fibroblast Cell Line | Gene: Lag3 (lymphocyte-activation gene 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, cell surface receptor signaling pathway, immune system process, innate immune response, negative regulation of T cell activation, negative regulation of int... |
Does Knockout of Cd300a in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Cd300a | cell proliferation | Mouse kidney carcinoma cell | Gene: Cd300a (CD300A molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of localization in cell, immune system process, intracellular signal transduction, negative regulation of B cell proliferation, negative regulation of B cell receptor signaling pa... |
Does Knockout of Scn4a in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Scn4a | phagocytosis | macrophage | Gene: Scn4a (sodium channel, voltage-gated, type IV, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: choline transport, membrane depolarization during action potential, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, n... |
Does Knockout of Zfp13 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Zfp13 | cell proliferation | Mouse kidney carcinoma cell | Gene: Zfp13 (zinc finger protein 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of mitochondrial outer membrane permeabilizat... |
Does Knockout of Rai14 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Rai14 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Rai14 (retinoic acid induced 14)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; jaw; neural ectoderm... |
Does Knockout of Ikzf3 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Ikzf3 | cell proliferation | Melanoma Cell Line | Gene: Ikzf3 (IKAROS family zinc finger 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell differentiation, T cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of B cell differentiation, regulation of B ce... |
Does Knockout of Arl6ip6 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Arl6ip6 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Arl6ip6 (ADP-ribosylation factor-like 6 interacting protein 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, nuclear inner membrane, nucleus
Pathways:
UniProt: Q8BH07
Entrez ID: 65103 |
Does Knockout of Cpne8 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Cpne8 | protein/peptide distribution | myoblast cell line | Gene: Cpne8 (copine VIII)
Type: protein-coding
Summary: This gene encodes a member of the copine family of highly conserved, calcium-dependent phospholipid binding proteins. The encoded protein has two characteristic C2 domains and a VWFA domain and may play a role in membrane trafficking. A related pse... |
Does Knockout of Uts2r in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,175 | Knockout | Uts2r | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Uts2r (urotensin 2 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, blood circulation, blood vessel diameter maintenance, negative regulation of blood pressure, negative regulation of glomerular filtration, nega... |
Does Knockout of Tbc1d5 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Tbc1d5 | cell proliferation | Regulatory T cell | Gene: Tbc1d5 (TBC1 domain family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, macroautophagy, positive regulation of receptor internalization, protein transport, response to starvation, retrograde transport, endosome to Golgi; MF: AP-2 adaptor com... |
Does Knockout of Prpf38b in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Prpf38b | cell proliferation | Regulatory T cell | Gene: Prpf38b (PRP38 pre-mRNA processing factor 38 (yeast) domain containing B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing; CC: nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Spliceosome - ... |
Does Knockout of Selp in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,179 | Knockout | Selp | cell proliferation | Colonic Cancer Cell Line | Gene: Selp (selectin, platelet)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell-cell adhesion, cellular response to interleukin-6, heterophilic cell-cell adhesion via pla... |
Does Knockout of Slc22a8 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Slc22a8 | cell proliferation | Mouse kidney carcinoma cell | Gene: Slc22a8 (solute carrier family 22 (organic anion transporter), member 8)
Type: protein-coding
Summary: Enables antiporter activity and organic anion transmembrane transporter activity. Predicted to be involved in glutathione transport; prostaglandin transport; and quaternary ammonium group transpo... |
Does Knockout of Zyg11b in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Zyg11b | protein/peptide distribution | myoblast cell line | Gene: Zyg11b (zyg-ll family member B, cell cycle regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins; CC: Cu... |
Does Knockout of Pdcd6ip in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Pdcd6ip | protein/peptide distribution | myoblast cell line | Gene: Pdcd6ip (programmed cell death 6 interacting protein)
Type: protein-coding
Summary: Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including actomyosin contractile ring assembly; bicellular tight junction assembly; and maintenance of ep... |
Does Knockout of 1700029H14Rik in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | 1700029H14Rik | protein/peptide distribution | myoblast cell line | Gene: 1700029H14Rik (RIKEN cDNA 1700029H14 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D9Y4, G3X906, E9PY36
Entrez ID: 66501 |
Does Knockout of Rpl35a in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Rpl35a | cell proliferation | Melanoma Cell Line | Gene: Rpl35a (ribosomal protein L35A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, rRNA processing, ribosomal large subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: ribonucleoprotein complex binding, s... |
Does Knockout of Pcdh9 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Pcdh9 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Pcdh9 (protocadherin 9)
Type: protein-coding
Summary: This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may ... |
Does Knockout of Numbl in Melanoma Cell Line causally result in cell proliferation? | 1 | 1,270 | Knockout | Numbl | cell proliferation | Melanoma Cell Line | Gene: Numbl (numb-like)
Type: protein-coding
Summary: Involved in lateral ventricle development; neuroblast division in subventricular zone; and positive regulation of neurogenesis. Acts upstream of or within adherens junction organization and nervous system development. Located in cytoplasm. Is express... |
Does Knockout of Arxes1 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Arxes1 | protein/peptide accumulation | Microglial Cell Line | Gene: Arxes1 (adipocyte-related X-chromosome expressed sequence 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fat cell differentiation, protein targeting to ER, signal peptide processing; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, signal pep... |
Does Knockout of Rgs8 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Rgs8 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Rgs8 (regulator of G-protein signaling 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled acetylcholine receptor signaling pathway, G protein-coupled receptor signaling pathway, negative regulation of signal transduction, positive regulation of GTP... |
Does Knockout of Actn3 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Actn3 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Actn3 (actinin alpha 3)
Type: protein-coding
Summary: This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking acti... |
Does Knockout of Gfra3 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Gfra3 | cell proliferation | Melanoma Cell Line | Gene: Gfra3 (glial cell line derived neurotrophic factor family receptor alpha 3)
Type: protein-coding
Summary: This gene encodes a cell surface glycoprotein and member of the glial cell line-derived neurotrophic receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed... |
Does Knockout of Ubl4b in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Ubl4b | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Ubl4b (ubiquitin-like 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytoplasm
Pathways:
UniProt: Q9CQ84
Entrez ID: 67591 |
Does Knockout of Zc3hc1 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Zc3hc1 | phagocytosis | macrophage | Gene: Zc3hc1 (zinc finger, C3HC type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, protein ubiquitination; MF: metal ion binding, protein kinase binding, zinc ion binding; CC: nuclear envelope, nuclear membrane, nuclear pore nuclear basket, nucleoplasm... |
Does Knockout of Zfp821 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Zfp821 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Zfp821 (zinc finger protein 821)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA b... |
Does Knockout of Ctsm in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Ctsm | protein/peptide accumulation | Regulatory T cell | Gene: Ctsm (cathepsin M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen catabolic process, fusion of virus membrane with host endosome membrane, fusion of virus membrane with host plasma membrane, protein autoprocessing, proteolysis, proteolysis involved in prot... |
Does Knockout of Ep400 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 81 | Knockout | Ep400 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Ep400 (E1A binding protein p400)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of apo... |
Does Knockout of Tor4a in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Tor4a | cell proliferation | Mouse kidney carcinoma cell | Gene: Tor4a (torsin family 4, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, molecular_function, nucleotide binding; CC: cytoplasm, endomembrane system, endoplasmic reticulum lumen, membrane, nuclear envelope
Pathw... |
Does Knockout of Lnpep in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,171 | Knockout | Lnpep | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Lnpep (leucyl/cystinyl aminopeptidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cold-induced thermogenesis, neuropeptide catabolic process, peptide catabolic process, positive regulation of blood pressure, protein catabolic process, pro... |
Does Knockout of Epm2a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 161 | Knockout | Epm2a | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Epm2a (epilepsy, progressive myoclonic epilepsy, type 2 gene alpha)
Type: protein-coding
Summary: Enables several functions, including alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity; phosphatase activity; and starch binding activity. Involved in carbohydrate phosphorylation and ... |
Does Knockout of Itpkb in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Itpkb | cell proliferation | Colonic Cancer Cell Line | Gene: Itpkb (inositol 1,4,5-trisphosphate 3-kinase B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, T cell differentiation, cell surface receptor signaling pathway, cellular response to calcium ion, common myeloid progenitor cell proliferation, inositol ph... |
Does Knockout of C1qtnf7 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | C1qtnf7 | cell proliferation | Mouse kidney carcinoma cell | Gene: C1qtnf7 (C1q and tumor necrosis factor related protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, protein binding; CC: collagen trimer, extracellular region, extracellular space
Pathways:
UniProt: Q8BVD7
... |
Does Knockout of Anxa7 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Anxa7 | cell proliferation | Embryonic Stem Cell Line | Gene: Anxa7 (annexin A7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, establishment of localization in cell, glial cell proliferation, hemostasis, intracellular calcium ion homeostasis, intracellular water homeostasis, ligand-gated ion channel signaling path... |
Does Knockout of Cct8l1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Cct8l1 | cell proliferation | Colonic Cancer Cell Line | Gene: Cct8l1 (chaperonin containing TCP1 subunit 8-like 1)
Type: protein-coding
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of chaperonin-containing T-complex. Orthologous to human CCT8L1P (chaperonin containing TCP1 s... |
Does Knockout of Rnf166 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Rnf166 | response to virus | Microglial Cell Line | Gene: Rnf166 (ring finger protein 166)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, immune system process, innate immune response, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, trans... |
Does Knockout of Ccdc146 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Ccdc146 | cell cycle progression | breast epithelium | Gene: Ccdc146 (coiled-coil domain containing 146)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, cell morphogenesis, cell population proliferation, cilium organization, flagellated sperm motility, gene expression, manchette assem... |
Does Knockout of Klk1b3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Klk1b3 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Klk1b3 (kallikrein 1-related peptidase b3)
Type: protein-coding
Summary: This gene encodes the gamma subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems.... |
Does Knockout of Atp10a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Atp10a | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Atp10a (ATPase, class V, type 10A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid transport, phospholipid translocation, phospholipid transport, positive regulation of membrane tubulation; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane... |
Does Knockout of Arl4a in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Arl4a | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Arl4a (ADP-ribosylation factor-like 4A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brown fat cell differentiation, intracellular protein transport, vesicle-mediated transport; MF: GTP binding, GTPase activity, nucleotide binding; CC: cytoplasm, cytosol, membran... |
Does Knockout of Tnfsf12 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Tnfsf12 | response to virus | Microglial Cell Line | Gene: Tnfsf12 (tumor necrosis factor (ligand) superfamily, member 12)
Type: protein-coding
Summary: Predicted to enable receptor ligand activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in extracellular region. Is expressed in Meckel's cartilage; limb; skeleton; and sup... |
Does Knockout of Vtcn1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,308 | Knockout | Vtcn1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Vtcn1 (V-set domain containing T cell activation inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, adaptive immune response, immune system process, negative regulation of T cell activation, negative regulation of T cell ... |
Does Knockout of Mertk in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Mertk | protein/peptide accumulation | Embryonic Cell Line | Gene: Mertk (MER proto-oncogene tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic cell clearance, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, establishment of localization in cell, gamete generation, natural ki... |
Does Knockout of Fbn2 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Fbn2 | cell proliferation | Regulatory T cell | Gene: Fbn2 (fibrillin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, bone trabecula formation, camera-type eye development, embryonic eye morphogenesis, embryonic limb morphogenesis, embryonic morphogenesis, glucose homeostasis, glucose met... |
Does Knockout of Cetn4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Cetn4 | protein/peptide distribution | myoblast cell line | Gene: Cetn4 (centrin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, microtubule cytoskeleton organization; MF: G-protein beta/gamma-subunit complex binding, calcium ion binding, heterotrimeric G-protein binding, metal ion binding; CC: centriole,... |
Does Knockout of Tmem196 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Tmem196 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Tmem196 (transmembrane protein 196)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3YWQ9
Entrez ID: 217951 |
Does Knockout of Ggh in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | Ggh | protein/peptide distribution | myoblast cell line | Gene: Ggh (gamma-glutamyl hydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: response to ethanol, response to insulin, response to xenobiotic stimulus, response to zinc ion, tetrahydrofolylpolyglutamate metabolic process; MF: gamma-glutamyl-peptidase activity, hyd... |
Does Knockout of Zfp934 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Zfp934 | response to virus | Neuroblastoma Cell Line | Gene: Zfp934 (zinc finger protein 934)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA ... |
Does Knockout of Fam184a in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Fam184a | cell proliferation | Melanoma Cell Line | Gene: Fam184a (family with sequence similarity 184, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: P-body, centriolar satellite, ciliary basal body, cytosol
Pathways:
UniProt: E9QAL2, E9PW83, F6R487, A0A1W2P7N4, A0A1W2P6N4, F6ZCT9, F6RSY8, A0... |
Does Knockout of Tubg1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Tubg1 | cell proliferation | Melanoma Cell Line | Gene: Tubg1 (tubulin, gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic spindle organization, microtubule nucleation, microtubule-based process, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle ... |
Does Knockout of Tmprss13 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Tmprss13 | protein/peptide distribution | myoblast cell line | Gene: Tmprss13 (transmembrane protease, serine 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of skin barrier, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, ex... |
Does Knockout of Aspa in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Aspa | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Aspa (aspartoacylase)
Type: protein-coding
Summary: This gene encodes an enzyme that deacteylates N-acetyl-L-aspartic acid (NAA) in the brain to yield acetate and L-aspartate. In humans, alterations in neuronal NAA concentration are associated with many neurodegenerative diseases (decrease associa... |
Does Knockout of Ctu2 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Ctu2 | response to bacteria | renal medulla cell line | Gene: Ctu2 (cytosolic thiouridylase subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: nucleotidyltransferase activity, sulf... |
Does Knockout of Tekt5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Tekt5 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Tekt5 (tektin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, cilium movement involved in cell motility, flagellated sperm motility; CC: axonemal A tubule inner sheath, cell projection, cilium, cytoplasm, cytoskeleton, microtubule cytoskeleton, m... |
Does Knockout of Foxd3 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Foxd3 | cell viability | Immortal mouse chromaffin cells | Gene: Foxd3 (forkhead box D3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, anatomical structure morphogenesis, cell differentiation, cellular response to leukemia inhibitory factor, embryonic placenta development, in utero embryonic develop... |
Does Knockout of Ccs in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Ccs | cell proliferation | Regulatory T cell | Gene: Ccs (copper chaperone for superoxide dismutase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: removal of superoxide radicals, superoxide metabolic process; MF: copper ion binding, enzyme binding, metal ion binding, superoxide dismutase copper chaperone activity; C... |
Does Knockout of Unc79 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Unc79 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Unc79 (unc-79 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult behavior, behavioral response to ethanol, multicellular organism growth, suckling behavior; CC: membrane, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels,... |
Does Knockout of Samm50 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Samm50 | protein/peptide distribution | myoblast cell line | Gene: Samm50 (SAMM50 sorting and assembly machinery component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cristae formation, protein import into mitochondrial matrix, protein insertion into mitochondrial outer membrane; CC: SAM complex, cytoplasm, membrane, mitochond... |
Does Knockout of 2410002F23Rik in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | 2410002F23Rik | cell proliferation | Mouse kidney carcinoma cell | Gene: 2410002F23Rik (RIKEN cDNA 2410002F23 gene)
Type: protein-coding
Summary: Predicted to be involved in response to virus. Predicted to be active in Golgi apparatus. Is expressed in central nervous system and retina. Orthologous to human C19orf48P (chromosome 19 open reading frame 48, pseudogene). [p... |
Does Knockout of Tas2r135 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Tas2r135 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Tas2r135 (taste receptor, type 2, member 135)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sens... |
Does Knockout of Mgst1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Mgst1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Mgst1 (microsomal glutathione S-transferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipid hydroperoxide, glutathione metabolic process, glutathione transport, response to lipopolysaccharide, response to xenobiotic stimulus; MF: glutat... |
Does Knockout of Sumo3 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Sumo3 | cell proliferation | Melanoma Cell Line | Gene: Sumo3 (small ubiquitin-like modifier 3)
Type: protein-coding
Summary: This gene encodes a member of the small ubiquitin-like modifier family. The encoded protein may regulate a variety of proteins in many pathways via a post-translational modification, known as SUMOylation. This activity may play ... |
Does Knockout of Copz1 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Copz1 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Copz1 (coatomer protein complex, subunit zeta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intra-Golgi vesicle-mediated transport, intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicl... |
Does Knockout of Ctnnb1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Ctnnb1 | cell proliferation | Melanoma Cell Line | Gene: Ctnnb1 (catenin beta 1)
Type: protein-coding
Summary: This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in th... |
Does Knockout of Errfi1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Errfi1 | protein/peptide distribution | myoblast cell line | Gene: Errfi1 (ERBB receptor feedback inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, bile acid biosynthetic process, cartilage development, cell migration, cellular hyperosmotic response, cellular response to dexamethasone stimulus, cellula... |
Does Knockout of Clpb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Clpb | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Clpb (ClpB caseinolytic peptidase B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RIG-I signaling pathway, antiviral innate immune response, cellular response to heat, granulocyte differentiation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein di... |
Does Knockout of Arglu1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,259 | Knockout | Arglu1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Arglu1 (arginine and glutamate rich 1)
Type: protein-coding
Summary: Enables pre-mRNA binding activity and transcription coactivator activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in several structures, including brain; genito... |
Does Knockout of Tmem67 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Tmem67 | protein/peptide accumulation | Microglial Cell Line | Gene: Tmem67 (transmembrane protein 67)
Type: protein-coding
Summary: Predicted to enable filamin binding activity; misfolded protein binding activity; and unfolded protein binding activity. Involved in several processes, including epithelial tube branching involved in lung morphogenesis; negative regul... |
Does Knockout of Spata1 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Spata1 | protein/peptide accumulation | Regulatory T cell | Gene: Spata1 (spermatogenesis associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein binding; CC: acrosomal vesicle, cytoplasmic vesicle
Pathways:
UniProt: Q9D5R4
Entrez ID: 70951 |
Does Knockout of Tgds in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,175 | Knockout | Tgds | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Tgds (TDP-glucose 4,6-dehydratase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, nucleotide-sugar metabolic process; MF: catalytic activity, dTDP-glucose 4,6-dehydratase activity, lyase activity, molecular_function
Pathways:
... |
Does Knockout of Zc3h12d in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Zc3h12d | phagocytosis | macrophage | Gene: Zc3h12d (zinc finger CCCH type containing 12D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, mRNA catabolic process, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell proliferation, ne... |
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