prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Vmn1r201 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Vmn1r201 | cell proliferation | Melanoma Cell Line | Gene: Vmn1r201 (vomeronasal 1 receptor 201)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromon... |
Does Knockout of Ush1g in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Ush1g | cell cycle progression | breast epithelium | Gene: Ush1g (USH1 protein network component sans)
Type: protein-coding
Summary: This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This prote... |
Does Knockout of Aqp9 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Aqp9 | cell cycle progression | breast epithelium | Gene: Aqp9 (aquaporin 9)
Type: protein-coding
Summary: This gene encodes a member of the aquaglyceroporin subfamily of aquaporins. This protein transports water, glycerol, urea, purines and pyrimidines and plays a role in glycerol metabolism and osteoclast differentiation. Alternative splicing results i... |
Does Knockout of Mgarp in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Mgarp | cell proliferation | Embryonic Stem Cell Line | Gene: Mgarp (mitochondria localized glutamic acid rich protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal transport, axon development, axonal transport of mitochondrion, cellular response to gonadotropin-releasing hormone, cellular response to hyp... |
Does Knockout of D430041D05Rik in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | D430041D05Rik | protein/peptide accumulation | Microglial Cell Line | Gene: D430041D05Rik (RIKEN cDNA D430041D05 gene)
Type: protein-coding
Summary: Is expressed in nervous system; neural retina; thymus; and upper jaw molar. Orthologous to human KIAA1549L (KIAA1549 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
... |
Does Knockout of Dnm2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 2,307 | Knockout | Dnm2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Dnm2 (dynamin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, Golgi to plasma membrane transport, actin filament bundle organization, aorta development, autophagy, cellular response to dopamine, centrosome cycle, corona... |
Does Knockout of Arhgap1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Arhgap1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Arhgap1 (Rho GTPase activating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosomal transport, negative regulation of endocytic recycling, signal transduction, small GTPase-mediated signal transduction, transferrin transport; MF: GTPase activator act... |
Does Knockout of Arhgap25 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Arhgap25 | protein/peptide accumulation | Microglial Cell Line | Gene: Arhgap25 (Rho GTPase activating protein 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, negative regulation of small GTPase mediated signal transduction, phagocytosis, engulfment, regulation of small GTPase mediated signal transducti... |
Does Knockout of Atg16l1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Atg16l1 | protein/peptide distribution | myoblast cell line | Gene: Atg16l1 (autophagy related 16 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, axonal transport, corpus callosum development, defense response to virus, dendrite arborization, hippocampus development, macroautophagy, microau... |
Does Knockout of Pcnx2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Pcnx2 | cell proliferation | Melanoma Cell Line | Gene: Pcnx2 (pecanex homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q5DU28
Entrez ID: 270109 |
Does Knockout of Jak1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Jak1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Jak1 (Janus kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell surface receptor signaling pathway via JAK-STAT, cellular response to interleukin-3, cellular response to interleukin-7, cytokine-mediated signaling pathway, enzyme-link... |
Does Knockout of Etv1 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Etv1 | cell proliferation | Embryonic Stem Cell Line | Gene: Etv1 (ets variant 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell differentiation, mechanosensory behavior, muscle organ development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II... |
Does Knockout of Kdm6b in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Kdm6b | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Kdm6b (KDM1 lysine (K)-specific demethylase 6B)
Type: protein-coding
Summary: Enables beta-catenin binding activity; histone H3K27me2/H3K27me3 demethylase activity; and sequence-specific DNA binding activity. Involved in several processes, including cardiac muscle cell differentiation; mesodermal ... |
Does Knockout of Taf6l in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Taf6l | cell proliferation | Regulatory T cell | Gene: Taf6l (TATA-box binding protein associated factor 6 like)
Type: protein-coding
Summary: Predicted to enable transcription coactivator activity. Involved in regulation of DNA-templated transcription and regulation of somatic stem cell population maintenance. Located in nucleus. Is expressed in tail... |
Does Knockout of Cep170 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Cep170 | response to bacteria | renal medulla cell line | Gene: Cep170 (centrosomal protein 170)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein binding; CC: centriolar subdistal appendage, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, microtubule, spindle
Pathw... |
Does Knockout of Pim2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Pim2 | cell proliferation | Melanoma Cell Line | Gene: Pim2 (proviral integration site 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, apoptotic mitochondrial changes, apoptotic process, negative regulation of apoptotic process, negative regulation of cell population proliferati... |
Does Knockout of Sost in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Sost | phagocytosis | macrophage | Gene: Sost (sclerostin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, cellular response to parathyroid hormone stimulus, negative regulation of BMP signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of canonical W... |
Does Knockout of Mettl2 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Mettl2 | protein/peptide distribution | myoblast cell line | Gene: Mettl2 (methyltransferase 2, methylcytidine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, tRNA methylation, tRNA processing; MF: RNA methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, tR... |
Does Knockout of Serpina1f in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Serpina1f | cell proliferation | Melanoma Cell Line | Gene: Serpina1f (serine (or cysteine) peptidase inhibitor, clade A, member 1F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: endoplasmic reticulum, extracellular region, extracellular space
... |
Does Knockout of Hsf2 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Hsf2 | protein/peptide accumulation | Embryonic Cell Line | Gene: Hsf2 (heat shock factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polym... |
Does Knockout of Vwa2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Vwa2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Vwa2 (von Willebrand factor A domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-independent cell-matrix adhesion, regulation of insulin receptor signaling pathway; MF: calcium ion binding, identical protein binding; CC: basement membrane, ... |
Does Knockout of Nup85 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Nup85 | protein/peptide accumulation | Mouse cell | Gene: Nup85 (nucleoporin 85)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemotaxis, cytokine-mediated signaling pathway, lamellipodium assembly, mRNA export from nucleus, mRNA transport, macrophage chemotaxis, nephron development, nucleocytoplasmic transport, positiv... |
Does Knockout of B4galt4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 165 | Knockout | B4galt4 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: B4galt4 (UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, glycosylation, keratan sulfate proteoglycan biosynthetic process, lactosylceramide biosynthetic process, lipid ... |
Does Knockout of Ncdn in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Ncdn | cell proliferation | Mouse kidney carcinoma cell | Gene: Ncdn (neurochondrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone resorption, neuron projection development, regulation of neuronal synaptic plasticity, regulation of postsynaptic neurotransmitter receptor internalization; CC: axon, cell projection, cytoplas... |
Does Knockout of Tmem232 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Tmem232 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Tmem232 (transmembrane protein 232)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell projection organization, flagellated sperm motility, maintenance of protein complex location, spermatid cytoplasm removal during spermiation of flagellated s... |
Does Knockout of Lrrc37a in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Lrrc37a | cell proliferation | Melanoma Cell Line | Gene: Lrrc37a (leucine rich repeat containing 37A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt:
Entrez ID: 237954 |
Does Knockout of Col4a3 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Col4a3 | response to virus | Microglial Cell Line | Gene: Col4a3 (collagen, type IV, alpha 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell surface receptor signaling pathway, collagen-activated tyrosine kinase receptor signaling pathway, endothelial cell apoptotic process, glomerular basement membran... |
Does Knockout of Fabp9 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Fabp9 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Fabp9 (fatty acid binding protein 9, testis)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: lipid binding, long-chain fatty acid binding; CC: acrosomal vesicle, cytoplasm, cytosol, nucleus
Pathways: Metabolism, Metabolism of lipids, Triglyceride catabolism... |
Does Knockout of Il16 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Il16 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Il16 (interleukin 16)
Type: protein-coding
Summary: Enables cytokine activity. Involved in cytokine-mediated signaling pathway. Acts upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutroph... |
Does Knockout of Tfg in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation? | 1 | 2,411 | Knockout | Tfg | cell proliferation | Cytotoxic T-lymphocyte (CD8+ T cells) | Gene: Tfg (Trk-fused gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport; MF: identical protein binding; CC: cytosol, endoplasmic reticulum exit site
Pathways: Asparagine N-linked ... |
Does Knockout of Efna1 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Efna1 | response to virus | Embryonic Fibroblast Cell Line | Gene: Efna1 (ephrin A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, aortic valve morphogenesis, axon guidance, cell migration, central nervous system neuron differentiation, endocardial cushion to mesenchymal transition involved in heart valve formation,... |
Does Knockout of Tmc1 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Tmc1 | phagocytosis | macrophage | Gene: Tmc1 (transmembrane channel-like gene family 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: auditory receptor cell development, calcium ion transmembrane transport, detection of mechanical stimulus involved in sensory perception of sound, monoatomic ion transmem... |
Does Knockout of Ralb in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Ralb | cell proliferation | Mouse kidney carcinoma cell | Gene: Ralb (v-ral simian leukemia viral oncogene B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, apoptotic process, cell division, positive regulation of autophagosome assembly, positive regulation of epidermal growth factor receptor si... |
Does Knockout of Ttll5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 163 | Knockout | Ttll5 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ttll5 (tubulin tyrosine ligase-like family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fertilization, flagellated sperm motility, retina development in camera-type eye, sperm axoneme assembly, spermatogenesis; MF: ATP binding, ligase activity, metal i... |
Does Knockout of Pbrm1 in Pancreatic Cell Line causally result in cell proliferation? | 1 | 2,191 | Knockout | Pbrm1 | cell proliferation | Pancreatic Cell Line | Gene: Pbrm1 (polybromo 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, blood vessel remodeling, cardiac vascular smooth muscle cell development, chromatin organization, chromatin remodeling, epicardium-derived cardiac endothelial cell differentiat... |
Does Knockout of Scn3a in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Scn3a | cell proliferation | Mouse kidney carcinoma cell | Gene: Scn3a (sodium channel, voltage-gated, type III, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: behavioral response to pain, cellular response to antibiotic, membrane depolarization during action potential, monoatomic ion transmembrane transport, monoatomic i... |
Does Knockout of Gab1 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Gab1 | protein/peptide distribution | Microglial Cell Line | Gene: Gab1 (growth factor receptor bound protein 2-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cellular response to vascular endothelial growth factor stimulus, endothelial cell chemotaxis, epidermal growth factor receptor signaling... |
Does Knockout of Prn in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Prn | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Prn (prion protein readthrough transcript)
Type: protein-coding
Summary: This locus represents naturally occurring readthrough transcription between the neighboring Prnp (major prion protein) and Prnd (prion-like protein doppel) genes on chromosome 2. The readthrough transcript encodes a protein t... |
Does Knockout of Sox11 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Sox11 | protein/peptide accumulation | Microglial Cell Line | Gene: Sox11 (SRY (sex determining region Y)-box 11)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including camera-type eye development; nervo... |
Does Knockout of Mettl18 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Mettl18 | protein/peptide accumulation | Regulatory T cell | Gene: Mettl18 (methyltransferase like 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, peptidyl-lysine monomethylation, regulation of rRNA processing, regulation of ribosome biogenesis, regulation of translation, regulation of translational elongation; MF:... |
Does Knockout of Prag1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Prag1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Prag1 (PEAK1 related kinase activating pseudokinase 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and protein kinase activity. Involved in regulation of Notch signaling pathway. Located in nucleus. Is expressed in forebrain; spinal cord; telencephalon; and... |
Does Knockout of Cd80 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,176 | Knockout | Cd80 | cell proliferation | Colonic Cancer Cell Line | Gene: Cd80 (CD80 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, T cell costimulation, cell surface receptor signaling pathway, cellular response to lipopolysaccharide, immune response, immune system process, negative regulation of T cell media... |
Does Knockout of Sat1 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Sat1 | response to virus | Microglial Cell Line | Gene: Sat1 (spermidine/spermine N1-acetyl transferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, polyamine biosynthetic process, polyamine catabolic process, polyamine metabolic process, putrescine catabolic process, regulation of cell population pro... |
Does Knockout of Clic4 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Clic4 | cell proliferation | Melanoma Cell Line | Gene: Clic4 (chloride intracellular channel 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, branching morphogenesis of an epithelial tube, cellular response to calcium ion, chloride transmembrane transport, chloride transport, endothelial cell morphogenes... |
Does Knockout of S100a2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | S100a2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: S100a2 (S100 calcium binding protein A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endothelial cell migration; MF: calcium ion binding, calcium-dependent protein binding, identical protein binding
Pathways:
UniProt: J3QMC7
Entrez ID:... |
Does Knockout of Pcdhga7 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Pcdhga7 | response to virus | Neuroblastoma Cell Line | Gene: Pcdhga7 (protocadherin gamma subfamily A, 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, pl... |
Does Knockout of Styxl1 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Styxl1 | protein/peptide accumulation | Mouse cell | Gene: Styxl1 (serine/threonine/tyrosine interacting-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of stress granule assembly, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of neuron projection development, ... |
Does Knockout of Cables2 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Cables2 | phagocytosis | macrophage | Gene: Cables2 (CDK5 and Abl enzyme substrate 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell division, regulation of cell cycle; CC: cellular_component, cytosol
Pathways:
UniProt: Q8K3M5
Entrez ID: 252966 |
Does Knockout of Serpina9 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Serpina9 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Serpina9 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extrace... |
Does Knockout of Dlst in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Dlst | cell proliferation | Mouse kidney carcinoma cell | Gene: Dlst (dihydrolipoamide S-succinyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate decarboxylation to succinyl-CoA, 2-oxoglutarate metabolic process, L-lysine catabolic process to acetyl-CoA via saccharopine, succinyl-CoA metabolic process,... |
Does Knockout of Gbp7 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Gbp7 | protein/peptide distribution | myoblast cell line | Gene: Gbp7 (guanylate binding protein 7)
Type: protein-coding
Summary: Enables GTP binding activity and GTPase activity. Involved in several processes, including cellular response to interferon-beta; cytolysis in another organism; and defense response to other organism. Acts upstream of or within adhesi... |
Does Knockout of Klhl15 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Klhl15 | response to chemicals | pro-B-lymphocyte | Gene: Klhl15 (kelch-like 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of double-strand break repair via homologous recombination, nuclear protein quality control by the ubiquitin-proteasome system, protein ubiquitination, ubiquitin-dependent pro... |
Does Knockout of Sfxn2 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Sfxn2 | response to virus | Microglial Cell Line | Gene: Sfxn2 (sideroflexin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, mitochondrial transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, serine import into mitochondrion, transmembrane transport; MF: monoa... |
Does Knockout of Nop53 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Nop53 | protein/peptide accumulation | Melanoma Cell Line | Gene: Nop53 (NOP53 ribosome biogenesis factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to hypoxia, mitotic G2 DNA damage checkpoint signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B ... |
Does Knockout of Stab1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Stab1 | cell proliferation | Melanoma Cell Line | Gene: Stab1 (stabilin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell signaling, defense response to bacterium, endocytosis, inflammatory response, negative regulation of angiogenesis; MF: calcium ion binding, hyaluronic acid binding, low-densi... |
Does Knockout of Sorbs3 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Sorbs3 | cell cycle progression | breast epithelium | Gene: Sorbs3 (sorbin and SH3 domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-substrate adhesion, negative regulation of transcription by RNA polymerase II, positive regulation of MAPK cascade, positive regulation of stress fiber as... |
Does Knockout of Pign in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Pign | cell proliferation | Melanoma Cell Line | Gene: Pign (phosphatidylinositol glycan anchor biosynthesis, class N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process; MF: mannose-ethanolamine phosphotransferase activity, transferase activity; CC: cytosol, endoplasmic reticulum, endoplasm... |
Does Knockout of Timd4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Timd4 | protein/peptide distribution | myoblast cell line | Gene: Timd4 (T cell immunoglobulin and mucin domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic cell clearance, cytoskeletal rearrangement involved in phagocytosis, engulfment; MF: phosphatidylserine binding, protein binding
Pathways: ... |
Does Knockout of Src in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Src | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Src (Rous sarcoma oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, TORC1 signaling, angiotensin-activated signaling pathway, bone resorption, branching involved in mammary gland duct morphogenesis, canonical glycolysis, cell adhesi... |
Does Knockout of Pmp22 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Pmp22 | cell proliferation | Colonic Cancer Cell Line | Gene: Pmp22 (peripheral myelin protein 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell development, Schwann cell differentiation, Schwann cell migration, actin cytoskeleton organization, adult locomotory behavior, adult walking behavior, aggresome assembl... |
Does Knockout of Syt2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Syt2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Syt2 (synaptotagmin II)
Type: protein-coding
Summary: This gene encodes a member of the synaptotagmin protein family. Synaptotagmin proteins are involved in membrane trafficking and are characterized by an N-terminal transmembrane region as well as tandem calcium binding domains. The encoded prote... |
Does Knockout of Abhd14a in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Abhd14a | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Abhd14a (abhydrolase domain containing 14A)
Type: protein-coding
Summary: Predicted to enable hydrolase activity. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and retina nuclear layer. Orthologous to human ABHD14A ... |
Does Knockout of Dync1li1 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Dync1li1 | protein/peptide accumulation | Microglial Cell Line | Gene: Dync1li1 (dynein cytoplasmic 1 light intermediate chain 1)
Type: protein-coding
Summary: Predicted to enable several functions, including GDP binding activity; dynein heavy chain binding activity; and identical protein binding activity. Predicted to be involved in several processes, including cell... |
Does Knockout of Mipol1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Mipol1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Mipol1 (mirror-image polydactyly 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular_function
Pathways:
UniProt: E9PZ24, G3UVV8
Entrez ID: 73490 |
Does Knockout of Herc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Herc1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Herc1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, bone remodeling, brain development, cerebellar Purkinje cell differentiation, corpus callosum development, gene ex... |
Does Knockout of Acot6 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Acot6 | protein/peptide accumulation | Microglial Cell Line | Gene: Acot6 (acyl-CoA thioesterase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acyl-CoA metabolic process, fatty acid metabolic process, lipid metabolic process; MF: carboxylic ester hydrolase activity, fatty acyl-CoA hydrolase activity, hydrolase activity, thioles... |
Does Knockout of Acbd7 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Acbd7 | phagocytosis | macrophage | Gene: Acbd7 (acyl-Coenzyme A binding domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, energy homeostasis, fatty acid metabolic process, gene expression, leptin-mediated signaling pathway, response to food; ... |
Does Knockout of Gzmk in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Gzmk | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Gzmk (granzyme K)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of membrane attack complex, complement activation, complement activation, GZMK pathway, granzyme-mediated programmed cell death signaling pathway, killing of cells of another organism, leuk... |
Does Knockout of Tmem126b in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Tmem126b | cell proliferation | Mouse kidney carcinoma cell | Gene: Tmem126b (transmembrane protein 126B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly, mitochondrion organization, response to food; CC: membrane, mitochondrial membrane, mitochondrion
Pathways: Aerobic res... |
Does Knockout of Cldnd2 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Cldnd2 | protein/peptide distribution | Microglial Cell Line | Gene: Cldnd2 (claudin domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q9D9H2
Entrez ID: 74276 |
Does Knockout of Haus7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 2,308 | Knockout | Haus7 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Haus7 (HAUS augmin-like complex, subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle, microtubule organizing center organization, spindle assembly; MF: microtubule minus-end binding, thioesterase binding; CC: HAUS complex, cent... |
Does Knockout of Pld5 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Pld5 | phagocytosis | macrophage | Gene: Pld5 (phospholipase D family member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: catalytic activity, hydrolase activity, acting on ester bonds, molecular_function; CC: cellular_component, endoplasmic reticulum membrane, membrane
Pathways:
Un... |
Does Knockout of Atp7b in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Atp7b | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Atp7b (ATPase, copper transporting, beta polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to copper ion, copper ion export, copper ion import, copper ion transport, establishment of localization in cell, intracellular copper ion homeost... |
Does Knockout of Dnajb12 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Dnajb12 | protein/peptide accumulation | Regulatory T cell | Gene: Dnajb12 (DnaJ heat shock protein family (Hsp40) member B12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, cellular response to misfolded protein, protein folding, protein-containing complex assembly; MF: Hsp70 protein binding; CC: endoplasmic reticul... |
Does Knockout of Pi15 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Pi15 | cell proliferation | Mouse kidney carcinoma cell | Gene: Pi15 (peptidase inhibitor 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q8BS03
Entrez ID: 94227 |
Does Knockout of Rnf11 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Rnf11 | cell cycle progression | breast epithelium | Gene: Rnf11 (ring finger protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein autoubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, earl... |
Does Knockout of Fam170b in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Fam170b | response to virus | Neuroblastoma Cell Line | Gene: Fam170b (family with sequence similarity 170, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fertilization, positive regulation of acrosome reaction, regulation of fertilization; CC: acrosomal vesicle, cytoplasmic vesicle, membrane, outer acrosomal membra... |
Does Knockout of Prlhr in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Prlhr | cell proliferation | Colonic Cancer Cell Line | Gene: Prlhr (prolactin releasing hormone receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, feeding behavior, hormone metabolic process, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled recepto... |
Does Knockout of Sult5a1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Sult5a1 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Sult5a1 (sulfotransferase family 5A, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: sulfotransferase activity, transferase activity; CC: cytoplasm
Pathways:
UniProt: Q3UQP7, Q91X36, D6RH78, D3Z6D1
Entrez ID: 57429 |
Does Knockout of Cdx2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Cdx2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Cdx2 (caudal type homeobox 2)
Type: protein-coding
Summary: Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in intestinal epithelial cell differentiation; positive regulation of transcription by RNA poly... |
Does Knockout of Poln in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Poln | response to virus | Microglial Cell Line | Gene: Poln (DNA polymerase N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA-templated DNA replication, double-strand break repair, double-strand break repair via homologous recombination, in... |
Does Knockout of Akap7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Akap7 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Akap7 (A kinase anchor protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, cAMP/PKA signal transduction, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to cAMP, intracellular protein localization, ... |
Does Knockout of Atrx in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Atrx | cell proliferation | Regulatory T cell | Gene: Atrx (ATRX, chromatin remodeler)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, Sertoli cell development, cellular response to hydroxyurea, chromatin organization, chro... |
Does Knockout of Ppp1r37 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Ppp1r37 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Ppp1r37 (protein phosphatase 1, regulatory subunit 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BKR5
Entrez ID: 232947 |
Does Knockout of Pus3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Pus3 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Pus3 (pseudouridine synthase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, mRNA pseudouridine synthesis, pseudouridine synthesis, tRNA processing, tRNA pseudouridine synthesis; MF: RNA binding, isomerase activity, pseudouridine synthase activi... |
Does Knockout of Rpl10a in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Rpl10a | cell proliferation | Mouse kidney carcinoma cell | Gene: Rpl10a (ribosomal protein L10A)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. ... |
Does Knockout of Cecr2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,172 | Knockout | Cecr2 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Cecr2 (CECR2, histone acetyl-lysine reader)
Type: protein-coding
Summary: Predicted to enable ATP-dependent chromatin remodeler activity. Acts upstream of or within inner ear development; primary neural tube formation; and single fertilization. Located in euchromatin and nucleus. Part of CERF comp... |
Does Knockout of Gmppa in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Gmppa | protein/peptide distribution | myoblast cell line | Gene: Gmppa (GDP-mannose pyrophosphorylase A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GDP-mannose biosynthetic process, GDP-mannose metabolic process, cognition, glycoprotein metabolic process, motor behavior, muscle organ morphogenesis, negative regulation of bio... |
Does Knockout of Mapk11 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Mapk11 | cell proliferation | Mouse kidney carcinoma cell | Gene: Mapk11 (mitogen-activated protein kinase 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, NLRP1 inflammasome complex assembly, bone development, cellular response to UV-B, cellular response to interleukin-1, cellular response to virus, intracellular... |
Does Knockout of Nrtn in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Nrtn | cell proliferation | Colonic Cancer Cell Line | Gene: Nrtn (neurturin)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosin... |
Does Knockout of Fads2 in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Fads2 | response to bacteria | macrophage | Gene: Fads2 (fatty acid desaturase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-linolenic acid metabolic process, arachidonate metabolite production involved in inflammatory response, fatty acid biosynthetic process, fatty acid derivative biosynthetic process,... |
Does Knockout of Adra2c in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Adra2c | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Adra2c (adrenergic receptor, alpha 2c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adrenergic receptor signaling pathway, epidermal growth fa... |
Does Knockout of Amy1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Amy1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Amy1 (amylase 1, salivary)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, response to bacterium; MF: alpha-amylase activity, amylase activity, calcium ion binding, catalytic activity, cation binding, chloride ion binding, hydrolase a... |
Does Knockout of Bnip2 in Microglial Cell Line causally result in response to virus? | 0 | 1,438 | Knockout | Bnip2 | response to virus | Microglial Cell Line | Gene: Bnip2 (BCL2/adenovirus E1B interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, blastocyst development, centrosome cycle, positive regulation of MAPK cascade, positive regulation of neuron differentiation, positive regulation of ... |
Does Knockout of Ada in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Ada | phagocytosis | macrophage | Gene: Ada (adenosine deaminase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMP catabolic process, AMP salvage, GMP salvage, IMP salvage, Peyer's patch development, T cell activation, adenosine catabolic process, adenosine metabolic process, allantoin metabolic proces... |
Does Knockout of Hs1bp3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Hs1bp3 | protein/peptide distribution | myoblast cell line | Gene: Hs1bp3 (HCLS1 binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, cell surface receptor signaling pathway, regulation of apoptotic process; MF: phosphatidylinositol binding, protein binding; CC: endoplasmic reticulum, mitochond... |
Does Knockout of Nsun5 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Nsun5 | protein/peptide distribution | myoblast cell line | Gene: Nsun5 (NOL1/NOP2/Sun domain family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, cerebral cortex development, cognition, corpus callosum development, methylation, oligodendrocyte development, positive regulation of translation, rRNA bas... |
Does Knockout of Syna in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Syna | protein/peptide distribution | myoblast cell line | Gene: Syna (syncytin a)
Type: protein-coding
Summary: Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a mouse endogenous retrovirus provirus on ... |
Does Knockout of Trappc13 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Trappc13 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Trappc13 (trafficking protein particle complex 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering; CC: TRAPPII protein complex, TRAPPIII protein complex, cytoplasm
... |
Does Knockout of Col6a1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Col6a1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Col6a1 (collagen, type VI, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate metabolic process, adipose tissue development, anatomical structure morphogenesis, apoptotic nuclear changes, apoptotic process, autophagy, basement membrane organizat... |
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