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converted_340 | Is it feasible to determine the complete proteome of yeast? | or model organisms like yeast, we can now quantify complete proteomes in just a few hours., A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis., So far, attempts to generate such maps for any proteome have failed to reach complete proteome coverage. Here we use a strategy bas... | yes |
converted_1237 | Has the protein GFP been used in transgenesis for live protein imaging? | we review recent advancement in the functional studies of the three different GnRH neuron systems, mainly focusing on the electrophysiological analysis of the GnRH-green fluorescent protein (GFP) transgenic animals., founders were found to be transgenic for GFP., GFP expression was detected in a wide range of murine ti... | yes |
converted_445 | Is there any relationship between histone ubiquitylation and splicing? | histone H2B-specific deubiquitinase and demonstrate that H2B deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons., H2B monoubiquitylation (H2BK123ub1) marks introns in Saccharomyces cerevisiae, H2B ubiquitination by facilitating splicing, pre-mRNA splicing plays a crit... | yes |
converted_3937 | Are mucins glycosylated proteins? | Many members of the mucin family are evolutionarily conserved and are often aberrantly expressed and glycosylated in various benign and malignant pathologies leading to tumor invasion, metastasis, and immune evasion., Mucin is a glycoprotein that is the primary component of the mucus overlaying the epithelial tissues. ... | yes |
converted_3834 | Does the use of bDMARDs during pregnancy impact neonatal development? | Exposure to bDMARDs during pregnancy does not seem to interfere with post-natal development up to infancy., Long-term follow-up data about newborns exposed to bDMARDs during pregnancy are however scarce. | no |
converted_4169 | Has dupilumab been FDA approved for atopic dermatitis? | Recent advances and understanding of the pathogenesis of AD have resulted in new therapies that target specific pathways with increased efficacy and the potential for less systemic side effects. New FDA-approved therapies for AD are crisaborole and dupilumab. , In March of 2017, the United States Food and Drug Administ... | yes |
converted_3503 | Are stretch enhancers transcribed more than super-enhancers? | Super-enhancers are transcriptionally more active and cell type-specific than stretch enhancers., We found that stretch enhancers are more abundant, more distal to transcription start sites, cover twice as much the genome, and are significantly less conserved than super-enhancers. In contrast, super-enhancers are signi... | no |
converted_1723 | Does fibronectin constitute a serum biomarker for Duchenne muscular dystrophy? | Fibronectin is a serum biomarker for Duchenne muscular dystrophy, There was a significant increase in fibronectin levels in DMD patients compared to age-matched controls. Fibronectin levels in patients with Becker muscular dystrophy, Bethlem myopathy, or myasthenia gravis were comparable to control levels. Progressive ... | yes |
converted_3951 | Does steroid 5A-Reductase deficiency lead to hermaphroditism? | 5α steroid reductase deficiency (5αSRD) is an autosomal recessive enzymatic deficiency and mutations in the 5α steroid reductase type 2 gene (SRD5A2) result in male pseudohermaphrodism caused by decreased dihydrotestosterone (DHT) synthesis., The diagnosis of steroid-5-alpha-reductase deficiency is rarely considered by... | yes |
converted_3226 | Is myc a tumour suppressor gene? | oncogenic Myc, a master transcription factor that turns on anabolic metabolism to promote cell growth in many cancers. , he MYC oncogene, the proto-oncogene protein c-MYC, however, other genes such as the proto-oncogene c-Myc are promising targets for anticancer therapy | no |
converted_1530 | Does triiodothyronine stimulate red blood cell sodium potassium pump? | reduction in Na+,K+ATPase activity has been demonstrated in red blood cells (RBCs), as well as an inverse correlation between this enzymatic action and free triiodothyronine (FT3) levels., The restoration of normal FT3 values also brings about a normalization of Na+,K+ATPase activity in erythrocytes., at hyperthyroid p... | no |
converted_839 | Are seizures among the neurological symptoms of incontinentia pigmenti? | High-dose glucocorticoid therapy in the management of seizures in neonatal incontinentia pigmenti, Incontinentia pigmenti is an X-linked dominant disorder resulting from a mutation of IKBKG. This disorder has a classic dermatologic presentation, but neurologic involvement, with seizures and cortical infarction, can ari... | yes |
converted_2286 | Does a tonsillectomy affect the patient's voice? | Group B had a better awareness of tooth damage (78% vs 30% of patients, P ≤ .001), voice change (61 vs 19%, P = .005), and burns to lips and mouth (44% vs 8%, P = .005). Finally, 35% more patients from group B rated their understanding of tonsillectomy as good or very good (P = .017)., Some patients complaint for dry... | yes |
converted_3339 | Can MVA85A confer immunity against smallpox? | We assessed the safety, immunogenicity, and efficacy of a candidate tuberculosis vaccine, modified vaccinia virus Ankara expressing antigen 85A (MVA85A), in adults infected with HIV-1., Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised,... | no |
converted_1861 | Is treatment resistant depression related to vitamin B9? | Suboptimal serum and red blood cell folate levels have been associated with a poorer response to antidepressant therapy, a greater severity of symptoms, later onset of clinical improvement, and overall treatment resistance. This article reviews the evidence for L-methylfolate and folic acid as antidepressive agents in ... | yes |
converted_2464 | Is Marfan syndrome associated with chordal rupture? | Repair of the mitral valve in children who have Marfan syndrome is especially difficult due to the presence of generalized connective tissue disorder, which may lead to future elongation and rupture of chordae tendineae that were unaffected at the time of mitral valve repair., Mitral regurgitation was caused by annulus... | yes |
converted_464 | Are people with blood group O protected against severe Malaria? | Differential carbonylation of cytoskeletal proteins in blood group O erythrocytes: potential role in protection against severe malaria., . Our findings indicate a possible correlation between the protection against severe malaria in blood group O individuals and a specific pattern of 4-HNE-carbonylation of cytoskeleton... | yes |
converted_4120 | Are Gram positive bacteria able to release extracellular vesicles? | Gram-negative and Gram-positive bacteria release a variety of membrane vesicles through different formation routes. , Release of extracellular vesicles (EVs) is a common feature among eukaryotes, archaea, and bacteria. However, the biogenesis and downstream biological effects of EVs released from gram-positive bacteria... | yes |
converted_4679 | Is there any role of the 'Greek islands' in olfactory receptor choice? | Chromatin conformation capture using in situ Hi-C on fluorescence-activated cell-sorted olfactory sensory neurons and their progenitors shows that olfactory receptor gene clusters from 18 chromosomes make specific and robust interchromosomal contacts that increase with differentiation of the cells. These contacts are o... | yes |
converted_347 | Could the Menzerath-Altmann law be proved mathematically trivial in genomes? | Here we review the statistical foundations of that test and consider three non-parametric tests based upon different correlation metrics and one parametric test to evaluate if Z ∼ 1/X in genomes. The most powerful test is a new non-parametric one based upon the correlation ratio, which is able to reject Z ∼ 1/X in nine... | yes |
converted_2874 | Are phagosomal proteins ubiquitinated? | Phagosomal proteins are ubiquitylated, and ubiquitylation was found to be required for formation of acidic multivesicular structures., membranes of the bacterial phagosome are enriched with ubiquitinated proteins in a way that requires its Dot/Icm type IV secretion system, suggesting the involvement of effectors in the... | yes |
converted_3556 | Is GRG5 involved only in late embryonic mouse development? | Groucho related gene 5 (GRG5) is a multifunctional protein that has been implicated in late embryonic and postnatal mouse development. Here, we describe a previously unknown role of GRG5 in early developmental stages by analyzing its function in stem cell fate decisions. By both loss and gain of function approaches we ... | no |
converted_1130 | Do DNA double-strand breaks play a causal role in carcinogenesis? | The DNA non-homologous end-joining repair gene XRCC6/Ku70 plays an important role in the repair of DNA double-strand breaks (DSBs) induced by both exogenous and endogenous DNA-damaging agents. Defects in overall DSB repair capacity can lead to genomic instability and carcinogenesis., The tumor suppressor breast cancer ... | yes |
converted_3143 | Velocardial facial syndrome, otherwise known as Di George syndrome is caused by a deletion in chromosome 21, yes or no? | The deletion of chromosome 22q11.2 is involved in the majority of DiGeorge or velo-cardiofacial syndrome., deletions of chromosome 7q11.23 (Williams syndrome), 15q11-q13 (Angelman syndrome, Prader-Willi syndrome) and 22q11 (Di George syndrome), Submicroscopic deletions of chromosome 22q11 have been reported in a multip... | no |
converted_137 | Is GAGA associated with nucleosome-free regions (NFR)? | One of the three nuclease hypersensitive sites in the Fab-7 boundary, HS1, contains multiple consensus-binding sequences for the GAGA factor, a protein known to be involved in the formation and/or maintenance of nucleosome-free regions of chromatin., The HS3 sequence contains consensus binding sites for the GAGA factor... | yes |
converted_3189 | Have apolipoprotein mimetics been used in clinical trials? | One of these (AEM-28) has recently been given orphan drug status and is undergoing clinical trials. | yes |
converted_2656 | Is Enlimomab effective for stroke treatment? | However, this treatment failed to show benefit in the Enlimomab Acute Stroke Trial., There was no increase in the frequency of adverse events with increasing doses of enlimomab.CONCLUSIONS: Doses of enlimomab between 140 and 480 mg administered over 5 days did not increase the risk of adverse events in patients with is... | no |
converted_985 | Is JTV519 (K201) a potential drug for the prevention of arrhythmias? | We compared the suppressive effect of K201 (JTV519), a multiple-channel blocker and cardiac ryanodine receptor-calcium release channel (RyR2) stabilizer, with that of diltiazem, a Ca(2+ )channel blocker, in 2 studies of isoproterenol-induced (n = 30) and ischemic-reperfusion-induced VAs (n = 38) in rats. , After admini... | yes |
converted_1468 | Is it possible to determine the proteome of a formalin fixed and paraffin embedded (FFPE) tissue? | ver the last few years, advances in methodology have made it possible to recover peptides from FFPE tissues that yield a reasonable representation of the proteins recovered from identical fresh or frozen specimens., Thus, laser capture microdissection of FFPE tissue coupled with downstream proteomic analysis is a valid... | yes |
converted_381 | Is cadasil syndrome a hereditary disease? | CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast... | yes |
converted_4025 | Is Lanabecestat effective for Alzheimer's disease? | INTRODUCTION: The APECS and AMARANTH trials showed that beta-secretase (BACE) inhibitors verubecestat and lanabecestat failed to slow cognitive and functional decline in individuals with prodromal or early Alzheimer's disease. , Conclusions and Relevance: Treatment with lanabecestat was well tolerated and did not slow ... | no |
converted_1484 | Can clonidine be used to reduce agitation in children. | Children receiving clonidine immediately after anesthesia induction had statistically significant improvement in postoperative agitation at the 15-minute mark (P = .096) and last score obtained (P = .095) using the Watcha scale., Clonidine has proven to be effective in reducing the incidence of post-operative agitation... | yes |
converted_2501 | Down's syndrome occurs when an individual has an extra copy or part of a copy of chromosome 21, yes or no? | Down syndrome (DS; trisomy 21) is the most common survivable disorder due to aneuploidy., Down syndrome (DS), trisomy 21, is caused by increased dose of genes present on human chromosome 21 (HSA21), Down syndrome, or Trisomy 21, is the most frequently occurring chromosomal abnormality in live-born children. , Down synd... | yes |
converted_3309 | Is induction of interferon by TLR7 higher in males? | ur results suggest that variations of TLR7 impair the immune response to HCV and imply a gender-specific effect of this X-chromosomal variation., The c.32A>T variation was over-represented in female patients with chronic HCV-infection compared to patients with other chronic liver diseases and to healthy controls (P < 0... | yes |
converted_1962 | Do normal cells express the protein TERT? | Since telomerase has been recognized as a relevant factor distinguishing cancer cells from normal cells, it has become a very promising target for anti-cancer therapy, Telomerase plays a pivotal role in cellular immortality and tumorigenesis. Its activity is normally not detectable in most somatic cells while it is rea... | no |
converted_1329 | Is p100 the precursor protein molecule of the NF-kappaB transcription factor subunit p50? | We previously reported that alymphoplasia (aly/aly) mice, which have a natural loss-of-function mutation in the Nik gene, which encodes a kinase essential for the processing of p100 to p52 in the alternative nuclear factor-κB (NF-κB) pathway, show mild osteopetrosis with an increase in several parameters of bone format... | no |
converted_3529 | Are CD8+ (cytotoxic) T cells and CD4+ Helper T cells generated in the thyroid and express the T-cell receptor? | A fundamental question in developmental immunology is how bipotential thymocyte precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages., CD4+CD8+ progenitor thymocytes undergo selection following interaction with MHC class I and class II molecules bearing peptide self-antigens, giving rise to CD8+ cyto... | no |
converted_1507 | Do thyroid hormone receptors change after brain injury? | For example, the T3 receptor alpha was predominantly expressed in stroke-tissue, indicating that regeneration of nerves in stroke tissue may be facilitated by increased T3 receptor alpha expression., TRα expression was also increased in human infants with IVH. , Thus, in infants with IVH the combined elevation in deiod... | yes |
converted_1071 | Are there any specific antidotes for dabigatran? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs. ,... | no |
converted_616 | Is statin use associated with improved outcomes after aneurysmal subarachnoid hemorrhage? | Statins have been shown in two recent small phase I/II trials to be associated with a marked reduction in clinical and transcranial Doppler (TCD) evidence of vasospasm after aneurysmal subarachnoid haemorrhage (SAH). , Statins did not result in reduced TCD velocities, clinical or angiographic vasospasm, or improvements... | yes |
converted_1005 | Is amoxicillin used for treatment of malnutrition in children? | Another RCT did not show superiority of ceftriaxone over amoxicilllin for these same outcomes, but adressed SAM children with and without complications (p = 0.27). Another RCT showed no difference between amoxicillin and cotrimoxazole efficacies for pneumonia in underweight, but not SAM. Our meta-analysis of 12 pooled... | yes |
converted_2791 | Is erythropoietin effective for treatment of amyotrophic lateral sclerosis? | This study was performed to validate the ALS-MITOS as a 6-month proxy of survival in 200 ALS patients followed up to 18 months.METHODS: Analyses were performed on data from the recombinant human erythropoietin RCT that failed to demonstrate differences between groups for both primary and secondary outcomes., CONCLUSION... | no |
converted_3835 | Do exon 38 or 39 KMT2D missense variants cause Kabuki syndrome type 1 (KS1)? | A restricted spectrum of missense KMT2D variants cause a multiple malformations disorder distinct from Kabuki syndrome., To investigate if specific exon 38 or 39 KMT2D missense variants (MVs) cause a condition distinct from Kabuki syndrome type 1 (KS1).METHODS: Multiple individuals, with MVs in exons 38 or 39 of KMT2D ... | no |
converted_418 | Is there evidence that tomato juice lowers cholesterol levels? | The hypocholesterolemic effect of tomato juice has been investigated in an intervention study with rats, along with the possible inhibition effect of bioactive tomato compounds binding to the HMGCR enzyme., The molecular modelling showed that components of tomato can bind to the active site of the enzyme and compete wi... | yes |
converted_3466 | Is Hemochromatosis type 4 is caused by a mutation in a recessive gene? | severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations, Hemochromatosis type 4, also known as ferroportin disease, is an autosomal dominant genetic disorder caused by pathogenic mutations in the SLC40A1 gene, whi... | no |
converted_2462 | Can radius fracture cause carpal tunnel syndrome? | Carpal tunnel syndrome (CTS) after distal radius fractures can present in 3 forms: acute, transient, and delayed., Complications were categorized as carpal tunnel syndrome, other sensibility issues, tendon complications including irritation and rupture, deep infections, complex regional pain syndrome and unidentified D... | yes |
converted_961 | Is it safe to use Abatacept during pregnancy? | These patients were exposed to rituximab (anti-CD20 monoclonal antibody) or abatacept (fusion protein CTLA4Ig) during the first trimester of their pregnancies. No significant adverse effects or complications were observed during the pregnancies, and all three patients delivered healthy newborns. , Despite these favorab... | no |
converted_4711 | Can METTL3 methylate long noncoding RNAs? | METTL3-Mediated lncRNA m6A Modification in the Osteogenic Differentiation of Human Adipose-Derived Stem Cells Induced by NEL-Like 1 Protein., This study aimed to explore the regulatory mechanism of methyltransferase3 (METTL3) -mediated long non-coding RNA (lncRNA) N6-methyladenosine (m6A) modification in the osteogenic... | yes |
converted_2092 | Can valproic acid prolong survival of glioblastoma patients? | For patients who presented with epilepsy, the use of the antiepileptic drug VPA did not associate with survival when compared with patients who did not receive VPA treatment., This prognostic effect is not solely explained by early diagnosis, and survival is not associated with VPA treatment., Several in vivo and in vi... | yes |
converted_3714 | Is deletion at 6q24.2-26 associated with shorter survival for ovarian cancer patients? | Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients., Standard treatments for advanced high-grade serous ovarian carcinomas (HGSOCs) show significant side-effects and provide only short-term survival benefits due to disease recurrence. Thus, identification of novel pro... | no |
converted_4256 | Is esophageal adenocarcinoma associated with aberrant glycosylation? | Altered glycoprotein expression has been demonstrated in tissue from patients with Barrett's esophagus and esophageal cancer but the mechanisms regarding such changes are unknown. , Esophageal adenocarcinoma represents a highly morbid and mortal cancer with a defined progression from metaplasia (Barrett's esophagus) to... | yes |
converted_3052 | Is Netrin-1 a secreted protein? | The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues, Netrin-1 is a secreted protein that directs long-range axon guidance during early stages of neural circuit formation and continues to be expressed in the mammalian forebrain during the postnatal period of peak synapse ... | yes |
converted_2063 | Is Melioidosis caused by the bacterium Burkholderia pseudomallei? | Burkholderia pseudomallei, the causative agent of melioidosis,, What drives the occurrence of the melioidosis bacterium Burkholderia pseudomallei in domestic gardens?, Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern Australia., Out of the ground: aer... | yes |
converted_516 | Is there an association between TERT promoter mutation and survival of glioma patients? | Mutations lead to TERT upregulation and are associated with aggressive clinical behavior in glioblastomas., Kaplan-Meier's survival analysis showed that TERT promoter mutation (P=0.037), Isocitrate dehydrogenase (IDH) mutation (P<0.001), and 1p/19q codeletion (P<0.001) were associated with favorable overall survival (O... | yes |
converted_545 | Have hESC been tested for the treatment of age-related macular degeneration? | Development of human embryonic stem cell therapies for age-related macular degeneration, In this review, we describe recent approaches to develop cell-based therapies for the treatment of AMD. Recent research has focused on replacing the retinal pigment epithelium (RPE), a monolayer of cells vital to photoreceptor cell... | yes |
converted_298 | Can a given genotype exhibit opposite fitness effects (beneficial and detrimental) within the same environment? | Mutations beneficial in one environment may cause costs in different environments, resulting in antagonistic pleiotropy. Here, we describe a novel form of antagonistic pleiotropy that operates even within the same environment, where benefits and deleterious effects exhibit themselves at different growth rates., The hfq... | yes |
converted_993 | Are there clinical trials using stem cells for the treatment of cardiac disease? | Therapy with mesenchymal stem cells is one of the promising tools to improve outcomes after myocardial infarction. Adipose-derived stem cells (ASCs) are an ideal source of mesenchymal stem cells due to their abundance and ease of preparation., Furthermore, several ongoing clinical trials using ASCs are producing promis... | yes |
converted_4469 | Is sacituzumab govitecan effective for breast cancer? | Sacituzumab Govitecan (also known by the brand name TRODELVY®) is a new and available treatment for metastatic triple-negative breast cancer, or mTNBC for short. , Sacituzumab govitecan (sacituzumab govitecan-hziy; Trodelvy™) is a Trop-2-directed antibody conjugated to a topoisomerase I inhibitor (SN-38) that is being ... | yes |
converted_166 | Are there any statistical methods for normalizing and identifying differential regions in histone modification ChIP-seq data? | ChIPnorm: a statistical method for normalizing and identifying differential regions in histone modification ChIP-seq libraries., In this paper we propose a two-stage statistical method, called ChIPnorm, to normalize ChIP-seq data, and to find differential regions in the genome, given two libraries of histone modificati... | yes |
converted_1219 | Can ferric carboxymaltose be used to treat anemia in inflammatory bowel disease patients? | Intravenous iron should be preferred where oral iron is poorly tolerated or where it has failed in moderate to severe anemia, and in combination with erythropoietin, Ferric carboxymaltose is much more convenient, and has been shown to be more effective than iron sucrose in a large randomized tria, nemia and iron defici... | yes |
converted_1335 | Is there increased incidence of incontinence in athletes? | Urinary incontinence affects women of all ages, including top female athletes, but is often under-reported. The highest prevalence of urinary incontinence is reported in those participating in high impact sports., The prevalence of female stress urinary incontinence is high, and young adults are also affected, includin... | yes |
converted_4112 | Is there a role for TFII-I in megakaryopoiesis? | TFII-I/Gtf2i and Erythro-Megakaryopoiesis., TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer. Williams-Beuren Syndrome (WBS) is caused by a large hemizyg... | yes |
converted_3712 | Are stem cell transplants used to treat acute kidney injury? | Animal studies have shown that mesenchymal stromal cell (MSC) infusions improve acute kidney injury (AKI) outcomes when administered early after ischemic/reperfusion injury or within 24 hours after cisplatin administration., Early Diagnostic Markers for Detection of Acute Kidney Injury in Allogeneic Hematopoietic Stem ... | yes |
converted_4600 | Is NfL (neurofilament light chain) a biomarker of neurodegeneration? | Neurofilament light chain (NfL) has recently been proposed as a promising biomarker in frontotemporal dementia (FTD). , Neurofilament light chain (NfL) is a new, non-disease specific, widely studied biomarker indicative of axonal injury and degeneration, the neurodegeneration biomarker neurofilament light chain (NfL) ,... | yes |
converted_362 | Is there a package in R/bioconductor for classification of alternative splicing? | spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data., Recent software improvements in full-length transcript deconvolution prompted us to develop spliceR, an R package for classification of alternative splicing and prediction of coding potential., splice... | yes |
converted_2542 | Is polyadenylation a process that stabilizes a protein by adding a string of Adenosine residues to the end of the molecule? | The addition of poly(A) tails to eukaryotic nuclear mRNAs promotes their stability, export to the cytoplasm and translation. , Most eukaryotic genes express mRNAs with alternative polyadenylation sites at their 3' ends, Polyadenylation is the non-template addition of adenosine nucleotides at the 3'-end of RNA, which oc... | no |
converted_3660 | Is Impetigo a viral infection that affects the skin? | Importance: Ozenoxacin, a novel topical antibacterial agent with potent bactericidal activity against gram-positive bacteria, has been developed as a cream with 1% active drug for the treatment of impetigo, a highly contagious bacterial skin infection, : To compare the in vitro activity of the anti-impetigo agent, ozen... | no |
converted_259 | Is oxidative stress affected by FOXO expression? | Forkhead-box class O (FoxO) transcription factors regulate mechanisms of cellular aging, including protein quality control, autophagy and defenses against oxidative stress., Statin-mediated upregulation of klotho expression and differential regulation of FoxO expression promote resistance to CsA-induced oxidative stres... | yes |
converted_4483 | Is resistance training usually associated with increasing muscle hypertrophy? | While traditional resistance exercises have been widely used to promote muscle strength and hypertrophy in the elderly, , These findings suggest that in young untrained men, progressing from a training frequency of once per week to a training frequency of 5 times per week with equated volume produces similar gains in ... | yes |
converted_3373 | Is the drug Exubera currently (March 2020) available? | Despite discontinuation of the first inhalable insulin, Exubera®, due to suboptimal market acceptance, development of orally inhaled insulin delivery systems has been galvanized by the recent approval of Afrezza® and several others awaiting approval. | no |
converted_3327 | Does Uc.63+ promote sensitivity to treatment in prostate cancer? | Transcribed ultraconserved region Uc.63+ promotes resistance to docetaxel through regulation of androgen receptor signaling in prostate cancer., The transcribed ultraconserved regions (T-UCRs) are a novel class of non-coding RNAs that are absolutely conserved across species and are involved in carcinogenesis including ... | no |
converted_1260 | Was tamoxifen tested for treatment of glioma patients? | Tamoxifen might have a role in the initial treatment of high-grade gliomas and should be studied in future Phase II trials building on the newly established platform of concurrent chemoradiotherapy., The addition of high-dose tamoxifen to standard radiotherapy does not improve the survival of patients with diffuse intr... | yes |
converted_4399 | Is gabapentin effective for chronic pelvic pain? | There were no significant between-group differences in both worst and average numerical rating scale (NRS) pain scores at 13-16 weeks after randomisation. The mean worst NRS pain score was 7·1 (standard deviation [SD] 2·6) in the gabapentin group and 7·4 (SD 2·2) in the placebo group. Mean change from baseline was -1·4... | no |
converted_3302 | Is the tyrosine kinase BTK implicated in autoimmunity? | Autoimmunity, hypersensitivity to B cell receptor (BCR) cross-linking, and splenomegaly caused by myeloerythroid hyperplasia were alleviated by Btk deficiency in lyn-/- mice., Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity., Autoimmunity wa... | yes |
converted_604 | Has the fungus Ashbya gossypii got many nuclei that share cytoplasm? | multinucleated Ashbya gossypii cells., multinucleated Ashbya gossypii fungal cells, Nuclei in the filamentous, multinucleated fungus Ashbya gossypii divide asynchronously. , multinucleated Ashbya gossypii cells, We analyzed a unique asynchronous nuclear division cycle in a multinucleated filamentous fungus, Ashbya goss... | yes |
converted_3561 | Is Niraparib effective for ovarian cancer? | Niraparib and olaparib have been approved by the US FDA for maintenance therapy after partial or complete remission in recurrent ovarian cancer., PURPOSE OF REVIEW: The recent United States Food and Drug Administration approvals of niraparib and olaparib as maintenance monotherapy for platinum-sensitive, high-grade ova... | yes |
converted_2660 | Can GDF15 be a biomarker for metformin treatment? | Growth Differentiation Factor 15 as a Novel Biomarker for Metformin., GDF15 levels are a biomarker for the use of metformin in people with dysglycemia, and its concentration reflects the dose of metformin. | yes |
converted_1750 | Is synapsin a phosphoprotein? | Synapsin is an evolutionarily conserved presynaptic phosphoprotein., Synapsins as a family of presynaptic terminal phosphoprotein participates in neuronal development, Synapsin III (SynIII) is a phosphoprotein, The neuronal phosphoprotein synapsin III, Synapsin II is a member of the neuronal phosphoprotein family., pho... | yes |
converted_2021 | Is siltuximab effective for Castleman disease? | Siltuximab: a targeted therapy for idiopathic multicentric Castleman disease., The recent approvals in North America, Europe and Brazil of siltuximab, a monoclonal antibody against IL-6, for iMCD now provide a safe and effective therapy that targets a key aspect of pathogenesis. In the first ever randomized, placebo-co... | yes |
converted_225 | Is it safe to take isotretinoin during pregnancy? | Isotretinoin is a remarkably effective drug for severe, recalcitrant acne vulgaris., a number of important adverse effects were reported, even the most recent pregnancy prevention program (iPledge) is no more successful than prior programs; there will likely always be a small number of female patients becoming pregnant... | no |
converted_211 | Is long QT syndrome a cause for sudden cardiac death in athletes? | A diversity of cardiovascular disorders including hypertrophic cardiomyopathy, congenital coronary anomalies, arrhythmogenic right ventricular dysplasia, dilated cardiomyopathy, aortic rupture due to Marfan syndrome, myocarditis, valvular disease and electrical disorders (Wolff-Parkinson-White syndrome, long QT syndrom... | yes |
converted_2786 | Do yeast LTR give rise to circular DNA? | Circular retrotransposition products generated by a LINE retrotransposon, Formation of Extrachromosomal Circular DNA from Long Terminal Repeats of Retrotransposons in Saccharomyces cerevisiae, Ty eccDNA can arise from the circularization of extrachromosomal linear DNA during the transpositional life cycle of retrotrans... | yes |
converted_3874 | Is isradipine effective for Parkinson's disease? | Adjusted least-squares mean changes in total UPDRS score in the antiparkinson medication ON state over 36 months for isradipine and placebo recipients were 2.99 (95% CI, 0.95 to 5.03) points versus 3.26 (CI, 1.25 to 5.26) points, respectively, with a treatment effect of -0.27 (CI, -3.02 to 2.48) point (P = 0.85)., Conc... | no |
converted_3448 | Is pimavanserin a typical antipsychotic? | Pimavanserin is the first FDA-approved atypical antipsychotic drug indicated for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis (PDP). | no |
converted_2570 | Is pregabalin effective for sciatica? | CONCLUSIONS: Treatment with pregabalin did not significantly reduce the intensity of leg pain associated with sciatica and did not significantly improve other outcomes, as compared with placebo, over the course of 8 weeks. The incidence of adverse events was significantly higher in the pregabalin group than in the plac... | no |
converted_3754 | Glucoraphanin from broccoli can help reduce obesity , yes or no? | Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance., A recent study demonstrated that glucoraphanin, a precursor of the Nrf2 activator sulforaphane, ameliorates obesity by enhancing energy expenditure and browning of white adipose tissue, and attenuates obesity... | yes |
converted_4708 | Can whole genome sequencing be used for diagnosis of mitochondrial disease? | Whole genome sequencing is a useful diagnostic test in patients with suspected mitochondrial disorders, yielding a diagnosis in a further 31% after exclusion of common causes. Most diagnoses were non-mitochondrial disorders and included developmental disorders with intellectual disability, epileptic encephalopathies, o... | yes |
converted_3484 | Is Selinexor effective for multiple myeloma? | Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia., Based on these findings, we conclude that selinexor in combination with dexamethasone is active in heavily pretreated MM and propose a RP2D of 45 mg/m2 (80 mg) plus 20 mg dexamethasone given twice weekly. , S... | yes |
converted_3186 | Are there any anti-amyloid antibody approved as drug for Alzheimer's disease treatment? | Treatment with memantine, a noncompetitive NMDA receptor antagonist which is an approved drug for treatment of Alzheimer's disease, rescued protein phosphatase-2A activity by decreasing its demethylation at Leu309 selectively and attenuated Alzheimer's disease-like pathology and cognitive impairment in adeno-associated... | no |
converted_2 | Is the protein Papilin secreted? | Using expression analysis, we identify three genes that are transcriptionally regulated by HLH-2: the protocadherin cdh-3, and two genes encoding secreted extracellular matrix proteins, mig-6/papilin and him-4/hemicentin. , We found that mig-6 encodes long (MIG-6L) and short (MIG-6S) isoforms of the extracellular matri... | yes |
converted_3711 | Was vivotif licensed in Europe and the US at the same time? | Vivotif® is an oral live attenuated vaccine which contains a mutated strain of Salmonella (Ty21a) and reproduces the natural infection. The vaccine was first licensed in Europe in 1983 and in the US in 1989, and over the years it has proved efficacious and safe. | no |
converted_3290 | Are ICAMS, Intracellular Adhesion Molecules, part of the immunoglobulin superfamily? | It has now been shown that adhesion molecules, particularly those of the immunoglobulin super family (e.g. ICAM-1, VCAM-1 and PECAM-1),, Intercellular adhesion molecule 3 (ICAM-3, also known as CD50), a human leukocyte-restricted immunoglobulin super-family (IgSF) member, has previously been implicated in apoptotic ce... | yes |
converted_2965 | There is no drug available to prevent HIV infection, Pre-exposure prophylaxis (PrEP), yes or no? | pre-exposure prophylaxis with generic tenofovir disoproxil fumarate/emtrictabine in London - analysis of pharmacokinetics, safety and outcomes., The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (TDF) is also ... | no |
converted_231 | Do orphan and gene related CpG islands follow power-law-like distributions? | Orphan and gene related CpG Islands follow power-law-like distributions in several genomes: evidence of function-related and taxonomy-related modes of distribution., Here, an investigation of their distributional characteristics in a variety of genomes is undertaken for both whole CGI populations as well as for CGI sub... | yes |
converted_642 | Are Alu elements transcribed? | Alu RNAs in the human transcriptome, Alu elements can be transcribed in two different ways, by two independent polymerases, 'Free Alu RNAs' are transcribed by Pol III from their own promoter, 'embedded Alu RNAs' are transcribed by Pol II as part of protein- and non-protein-coding RNAs, Recent studies have demonstrated ... | yes |
converted_2455 | Is LDB1-mediated enhancer looping dependent on cohesin? | LDB1-mediated enhancer looping can be established independent of mediator and cohesin., Moreover, ENCODE data and our chromatin immunoprecipitation results indicate that cohesin is almost completely absent from validated and predicted LDB1-regulated erythroid enhancer-gene pairs. Thus, lineage specific factors largely ... | no |
converted_2265 | Does echinacea increase anaphylaxis risk? | Chicoric acid (dicaffeoyl-tartaric acid), is a natural phenolic compound found in a number of plants, such as chicory (Cichorium intybus) and Echinacea (Echinacea purpurea), which possesses antioxidant, anti-inflammatory, antiviral, and analgesic activities. Although these biological effects of chicoric acid have been ... | yes |
converted_2902 | Is lithium effective for treatment of amyotrophic lateral sclerosis? | In terms of disease-modifying treatment options, several drugs such as dexpramipexole, pioglitazone, lithium, and many others have been tested in large multicenter trials, albeit with disappointing results., Despite several positive case reports and short studies, further controlled researches have failed to substantia... | no |
converted_109 | Does TGF-beta play a role in cardiac regeneration after myocardial infarction? | We then performed a chemical screen and identified several small molecules that increase or reduce cardiomyocyte proliferation during heart development. These compounds act via Hedgehog, Insulin-like growth factor or Transforming growth factor β signaling pathways. , Here, we report that the balance between the reparat... | yes |
converted_1360 | Is triadin involved in cardiac function? | Junctin (JCN), a 26-kd sarcoplasmic reticulum (SR) transmembrane protein, forms a quaternary protein complex with the ryanodine receptor, calsequestrin, and triadin in the SR lumen of cardiac muscle. Within this complex, calsequestrin, triadin, and JCN appear to be critical for normal regulation of ryanodine receptor-m... | yes |
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