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10. 1002/advs. 202206875 | 2,023 | Advanced Science | Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration | Abstract Osteoarthritis (OA) is a degenerative disease that often causes cartilage lesions and even osteochondral damage. Osteochondral defects induced by OA are accompanied by an inflammatory arthrosis microenvironment with overproduced reactive oxygen species (ROS), resulting in the exacerbation of defects and diffic... | 1 Introduction Osteoarthritis (OA) is a prevalent degenerative disease causes joint damage. The patients who suffer OA are often faced with defective loss of cartilage and pathological injury of the underlying bone, leading to osteochondral defects. [ 1 ] Studies have found that the progression and pathogenesis of OA a... |
10. 1002/advs. 202207020 | 2,023 | Advanced Science | Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells Inhibits Fibrosis and Exacerbates Degeneration in a HEYL‐Dependent Manner | Abstract The mechanisms of meniscus fibrosis and novel ways to enhance fibrosis is unclear. This work reveals human meniscus fibrosis initiated at E24 weeks. Smooth muscle cell cluster is identified in embryonic meniscus, and the combined analysis with previous data suggests smooth muscle cell in embryonic meniscus as ... | 1 Introduction During human limb development, the meniscus originates from the interzone between the tibia and the femur, and the typical meniscus structure is formed from weeks 7 to 8 of embryonic development. [ 1 ] In the beginning of this process, the meniscus is fully vascularized, and as it develops, the meniscus ... |
10. 1002/advs. 202207050 | 2,023 | Advanced Science | Cell‐Based Therapies for Degenerative Musculoskeletal Diseases | Abstract Degenerative musculoskeletal diseases (DMDs), including osteoporosis, osteoarthritis, degenerative disc disease, and sarcopenia, present major challenges in the aging population. Patients with DMDs present with pain, functional decline, and reduced exercise tolerance, which result in long‐term or permanent def... | 1 Introduction Degenerative musculoskeletal diseases (DMDs) include various age‐related disorders of the musculoskeletal system, among which osteoporosis, osteoarthritis (OA), sarcopenia, and degenerative joint diseases have the highest incidence. Patients with these diseases experience increased pain, a decreased rang... |
10. 1002/advs. 202207089 | 2,023 | Advanced Science | 3D Biomimetic Calcified Cartilaginous Callus that Induces Type H Vessels Formation and Osteoclastogenesis | Abstract The formation of a calcified cartilaginous callus (CACC) is crucial during bone repair. CACC can stimulate the invasion of type H vessels into the callus to couple angiogenesis and osteogenesis, induce osteoclastogenesis to resorb the calcified matrix, and promote osteoclast secretion of factors to enhance ost... | 1 Introduction The regeneration of large‐segment bone defects caused by infection, trauma, and tumors remains a substantial clinical challenge owing to the lack of normal bone repair processes, leading to delayed healing or even nonhealing. [ 1 ] Normal bone healing is similar to bone development and involves multiple ... |
10. 1002/advs. 202207165 | 2,023 | Advanced Science | Molecular/Nanomechanical Insights into Electrostimulation‐Inhibited Energy Metabolism Mechanisms and Cytoskeleton Damage of Cancer Cells | Abstract Inhibiting energy metabolism of cancer cells is an effective way to treat cancer but remains a great challenge. Herein, electrostimulation (ES) is applied to effectively suppress energy metabolism of cancer cells to induce rapid cell death, and deeply reveal the underlying mechanisms at the molecular and nanom... | 1 Introduction Cellular bioenergetics is closely related to cell fates such as cell proliferation, differentiation, and apoptosis, [ 1, 2, 3 ] and the development of metabolic diseases. [ 4 ] Especially, tumor initiation and progression are accompanied by accelerated nutrient uptake and intensive alterations in cellula... |
10. 1002/advs. 202207192 | 2,023 | Advanced Science | Advanced Composites Inspired by Biological Structures and Functions in Nature: Architecture Design, Strengthening Mechanisms, and Mechanical‐Functional Responses | Abstract The natural design and coupling of biological structures are the root of realizing the high strength, toughness, and unique functional properties of biomaterials. Advanced architecture design is applied to many materials, including metal materials, inorganic nonmetallic materials, polymer materials, and so on.... | 1 Introduction Advanced materials through architecture design exhibit excellent mechanical properties, functional physical properties, and unique coupling properties. [ 1, 2, 3, 4, 5 ] They play a fundamental role in promoting the progress of materials science, biology, and physics. [ 6, 7, 8, 9, 10 ] Although many mic... |
10. 1002/advs. 202207334 | 2,023 | Advanced Science | An Update on Adipose‐Derived Stem Cells for Regenerative Medicine: Where Challenge Meets Opportunity | Abstract Over the last decade, adipose‐derived stem cells (ADSCs) have attracted increasing attention in the field of regenerative medicine. ADSCs appear to be the most advantageous cell type for regenerative therapies owing to their easy accessibility, multipotency, and active paracrine activity. This review highlight... | 1 Introduction The past few decades have witnessed exponential growth in regenerative medicine. As an important branch of regenerative medicine, stem cell‐based therapy opens a new avenue for patients with incurable diseases for whom conventional treatments fail. The goal of stem cell‐based therapy is to rejuvenate or ... |
10. 1002/advs. 202207347 | 2,023 | Advanced Science | Super‐Elastic Carbonized Mushroom Aerogel for Management of Uncontrolled Hemorrhage | Abstract Uncontrolled hemorrhage is still the most common cause of potentially preventable death after trauma in prehospital settings. However, there rarely are hemostatic materials that can achieve safely and efficiently rapid hemostasis simultaneously. Here, new carbonized cellulose‐based aerogel hemostatic material ... | 1 Introduction Uncontrolled bleeding, particularly noncompressible torso hemorrhage (NCTH) and compressible junctional (limb‐torso intersection) hemorrhage (CJH), is the leading cause of trauma death in both battlefield injuries and other fortuitous accidents (e. g. , road traffic crashes, occupational injuries). Given... |
10. 1002/advs. 202207400 | 2,023 | Advanced Science | Using Wool Keratin as a Structural Biomaterial and Natural Mediator to Fabricate Biocompatible and Robust Bioelectronic Platforms | Abstract The design and fabrication of biopolymer‐incorporated flexible electronics have attracted immense interest in healthcare systems, degradable implants, and electronic skin. However, the application of these soft bioelectronic devices is often hampered by their intrinsic drawbacks, such as poor stability, inferi... | 1 Introduction The development of flexible and stretchable electronics has experienced a boom in the past decades owing to their emerging applications in personal healthcare, electronic skin, and robotic actuation. [ 1, 2, 3, 4, 5, 6, 7, 8, 9 ] Natural polymers (such as silk, keratin, cellulose, and gelatin) offer an a... |
10. 1002/advs. 202207403 | 2,023 | Advanced Science | Type‐Independent 3D Writing and Nano‐Patterning of Confined Biopolymers | Abstract Biopolymers are essential building blocks that constitute cells and tissues with well‐defined molecular structures and diverse biological functions. Their three‐dimensional (3D) complex architectures are used to analyze, control, and mimic various cells and their ensembles. However, the free‐form and high‐reso... | 1 Introduction At the submicron scale, the availability of biopolymer‐based diverse three‐dimensional (3D) architectures enables the precise control of cells and tissues for in vitro and in vivo applications. [ 1 ] Biological polymers, such as nucleic acids, proteins, and glycans, which are essential building blocks of... |
10. 1002/advs. 202207436 | 2,023 | Advanced Science | Advanced Temporally‐Spatially Precise Technologies for On‐Demand Neurological Disorder Intervention | Abstract Temporal‐spatial precision has attracted increasing attention for the clinical intervention of neurological disorders (NDs) to mitigate adverse effects of traditional treatments and achieve point‐of‐care medicine. Inspiring steps forward in this field have been witnessed in recent years, giving the credit to m... | 1 Introduction In ingenious human nervous systems, over 14 billion neurons collaborate exquisitely and constitute intricate neural networks to perform a myriad of neurophysiological activities including sensation, motor, memory, and emotion. [ 1 ] Any damage or dysfunction of neural circuits could result in undesirable... |
10. 1002/advs. 202207438 | 2,023 | Advanced Science | Visualizable and Lubricating Hydrogel Microspheres Via NanoPOSS for Cartilage Regeneration | Abstract The monitoring of tissue regeneration is particularly important. However, most materials do not allow direct observation of the regeneration process in the cartilage layer. Here, using sulfhydryl polyhedral oligomeric silsesquioxane (POSS‐SH) as a nano‐construction platform, poly(ethylene glycol) (PEG), Kartog... | 1 Introduction Tissue regeneration is primarily used for the replacement, regeneration, and reconstruction of organs. [ 1 ] The development of a new method to promote tissue regeneration requires better monitoring of the interaction between the engineered and host tissues, as well as the degree of tissue anastomosis. C... |
10. 1002/advs. 202207536 | 2,023 | Advanced Science | Nerve‐on‐a‐Chip Derived Biomimicking Microfibers for Peripheral Nerve Regeneration | Abstract Fibrous scaffolds have shown their advantages in tissue engineering, such as peripheral nerve regeneration, while most of the existing fiber‐shaped scaffolds are with simple structures, and the in vitro performance for nerve regeneration lacks systematic analysis. Here, novel nerve‐on‐a‐chip derived biomimicki... | 1 Introduction Peripheral nerve injury has become such a common but severe problem in the daily life of patients that it calls for efficient interventions or therapies. [ 1 ] Existing approaches like autografts, allografts, and chemical or electrical stimulations have fortunately gained gratifying achievements, while t... |
10. 1002/advs. 202207715 | 2,023 | Advanced Science | Arthritic Microenvironment‐Dictated Fate Decisions for Stem Cells in Cartilage Repair | Abstract The microenvironment and stem cell fate guidance of post‐traumatic articular cartilage regeneration is primarily the focus of cartilage tissue engineering. In articular cartilage, stem cells are characterized by overlapping lineages and uneven effectiveness. Within the first 12 weeks after trauma, the articula... | 1 Introduction Articular cartilage injury is an important problem worldwide. [ 1 ] Articular cartilage is a lymphatic connective tissue that does not contain blood vessels or nerves. It is particularly difficult for articular cartilage within load‐bearing joints to recover normal function following injury, [ 2 ] as dis... |
10. 1002/advs. 202207759 | 2,023 | Advanced Science | Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano‐Bio‐Platforms | Abstract Engineering advanced therapeutic and diagnostic nano‐bio‐platforms (NBPFs) have emerged as rapidly‐developed pathways against a wide range of challenges in antitumor, antipathogen, tissue regeneration, bioimaging, and biosensing applications. Emerged 2D materials have attracted extensive scientific interest as... | 1 Introduction Recently developed nanomaterials‐based therapeutic and diagnostic nano‐bio‐platforms (NBPFs) have resulted in new horizons for creating new pathways and breakthroughs against a wide range of challenging diseases, [ 1, 2, 3, 4, 5 ] for instance, cancer therapeutics, pathogen inhibition, tissue regeneratio... |
10. 1002/advs. 202270028 | 2,022 | Advanced Science | Extracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization (Adv. Sci. 5/2022) | Extracellular DNA In article number 2103693, Li‐na Niu and co‐workers discuss a fascinating novel function of extracellular DNA as mineralization initiators in ectopic calcification. Extracellular DNAs regulate matrix calcification outside cells and participate in extracellular mineral nucleation and collagen mineraliz... | No full text available |
10. 1002/advs. 202300038 | 2,023 | Advanced Science | Nanostructured 3D‐Printed Hybrid Scaffold Accelerates Bone Regeneration by Photointegrating Nanohydroxyapatite | Abstract Nanostructured biomaterials that replicate natural bone architecture are expected to facilitate bone regeneration. Here, nanohydroxyapatite (nHAp) with vinyl surface modification is acquired by silicon‐based coupling agent and photointegrated with methacrylic anhydride‐modified gelatin to manufacture a chemica... | 1 Introduction Inevitable limitations of autologous and allogeneic bone grafts necessitate the development of functional artificial bony implants with biomimetic composition and structure. [ 1, 2 ] Therein, exogenous cells and growth factors in bone tissue engineering (BTE) scaffolds present an unpredictable clinical r... |
10. 1002/advs. 202300055 | 2,023 | Advanced Science | Clickable Dynamic Bioinks Enable Post‐Printing Modifications of Construct Composition and Mechanical Properties Controlled over Time and Space | Abstract Bioprinting is a booming technology, with numerous applications in tissue engineering and regenerative medicine. However, most biomaterials designed for bioprinting depend on the use of sacrificial baths and/or non‐physiological stimuli. Printable biomaterials also often lack tunability in terms of their compo... | 1 Introduction 3D bioprinting technology holds great promise toward advancing the fields of tissue engineering and regenerative medicine, [ 1 ] with applications spanning from disease modeling to drug testing and tissue replacement. [ 2, 3, 4, 5 ] Bioprinting allows for the 3D arrangement of biomaterials and cells, com... |
10. 1002/advs. 202300475 | 2,023 | Advanced Science | Revealing the Role of Zinc Ions in Atherosclerosis Therapy via an Engineered Three‐Dimensional Pathological Model | Abstract An incomplete understanding of the cellular functions and underlying mechanisms of zinc ions released from zinc‐based stents in atherosclerosis (AS) therapy is one of the major obstacles to their clinical translation. The existing evaluation methodology using cell monolayers has limitations on accurate results... | 1 Introduction Cardiovascular diseases (CVDs) have been the leading cause of death over the past few decades. Atherosclerosis (AS), contributing to the formation of fatty lesions and vascular occlusions on the arterial wall, is the major pathological basis of CVDs. [ 1 ] To date, the implantation of vascular stents is ... |
10. 1002/advs. 202300516 | 2,023 | Advanced Science | A Recombinant Parathyroid Hormone‐Related Peptide Locally Applied in Osteoporotic Bone Defect | Abstract The local application of drug‐loaded bioactive scaffold materials is one of the important directions to solve the clinical problem of osteoporotic (OP) bone defects. This study retains the advantages of drug loading and mechanical properties of natural 3D bioactive scaffolds. The scaffolds are functionally mod... | 1 Introduction Osteoporosis (OP) is a common metabolic bone disease caused by an imbalance in homeostasis within the bone tissue, which predisposes to adverse clinical outcomes such as increased fracture risk and fracture severity. Maintaining the structural stability of internal fixation in osteoporotic fractures is i... |
10. 1002/advs. 202300517 | 2,023 | Advanced Science | Ferroptosis‐Enhanced Immunotherapy with an Injectable Dextran‐Chitosan Hydrogel for the Treatment of Malignant Ascites in Hepatocellular Carcinoma | Abstract Malignant ascites in advanced hepatocellular carcinoma (HCC) is a complex clinical problem that lacks effective treatments. Due to the insensitivity of advanced HCC cells to traditional chemotherapies, low drug accumulation, and limited drug residence time in the peritoneal cavity, the therapeutic effects of m... | 1 Introduction Hepatocellular carcinoma (HCC) represents a significant public health issue globally, particularly in East Asia and Africa, and is a leading cause of cancer‐related death. [ 1, 2 ] Since 2015, significant advances have been made in the management of HCC, especially in the development of systematic therap... |
10. 1002/advs. 202300658 | 2,023 | Advanced Science | Composite Nanocoatings of Biomedical Magnesium Alloy Implants: Advantages, Mechanisms, and Design Strategies | Abstract The rapid degradation of magnesium (Mg) alloy implants erodes mechanical performance and interfacial bioactivity, thereby limiting their clinical utility. Surface modification is among the solutions to improve corrosion resistance and bioefficacy of Mg alloys. Novel composite coatings that incorporate nanostru... | 1 Introduction Magnesium (Mg)‐based alloys have multiple biomedical applications due to their mechanical properties (including high specific strength and low density) that approximate those of human bone. Released Mg 2+ ions are among the elements essential to cell division and proliferation, muscle contraction, and ne... |
10. 1002/advs. 202300668 | 2,023 | Advanced Science | Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges | Abstract Early clinical diagnosis, effective intraoperative guidance, and an accurate prognosis can lead to timely and effective medical treatment. The current conventional clinical methods have several limitations. Therefore, there is a need to develop faster and more reliable clinical detection, treatment, and monito... | 1 Introduction Nearly 75% of all deaths worldwide are caused by chronic illnesses such as cancer, heart disease, and lung disease, which have significantly increased in prevalence. [ 1 ] The prompt and efficient administration of treatments is facilitated by an early clinical diagnosis, effective intraoperative guidanc... |
10. 1002/advs. 202300670 | 2,023 | Advanced Science | Dynamic Stimulations with Bioengineered Extracellular Matrix‐Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy | Abstract Cells interact with their surrounding environment through a combination of static and dynamic mechanical signals that vary over stimulus types, intensity, space, and time. Compared to static mechanical signals such as stiffness, porosity, and topography, the current understanding on the effects of dynamic mech... | 1 Introduction The state and behavior of a cell are dynamic and they are a function of its intrinsic characteristics (e. g. , genetic makeup, cytoskeletal contractility, and metabolic signaling pathways) and its interaction with the local environment. [ 1, 2 ] The extracellular microenvironment consists of the extracel... |
10. 1002/advs. 202300694 | 2,023 | Advanced Science | Reconfigurable Magnetic Liquid Building Blocks for Constructing Artificial Spinal Column Tissues | Abstract All‐liquid molding can be used to transform a liquid into free‐form solid constructs, while maintaining internal fluidity. Traditional biological scaffolds, such as cured pre‐gels, are normally processed in solid state, sacrificing flowability and permeability. However, it is essential to maintain the fluidity... | 1 Introduction All‐liquid molding, [ 1, 2 ] has opened a promising path to mold aqueous solutions into permanent non‐equilibrium shapes while retaining their liquid fluidity. This technique has been developed and widely used in fabricating functional devices with a remarkable bulk fluidity and fixed surface morphology ... |
10. 1002/advs. 202300812 | 2,023 | Advanced Science | Engineered Biomimetic Fibrillar Fibronectin Matrices Regulate Cell Adhesion Initiation, Migration, and Proliferation via | Abstract Cells regulate adhesion to the fibrillar extracellular matrix (ECM) of which fibronectin is an essential component. However, most studies characterize cell adhesion to globular fibronectin substrates at time scales long after cells polarize and migrate. To overcome this limitation, a simple and scalable method... | 1 Introduction Tissue‐specific biochemical compositions and biophysical properties of 3D fibrillar extracellular matrices (ECM) modulate the cellular response and hence play crucial roles in physiology and pathology. [ 1 ] Fibronectin (FN) is a structural and biochemical component of the ECM that is indispensable for d... |
10. 1002/advs. 202300816 | 2,023 | Advanced Science | 3D‐Printed Functional Hydrogel by DNA‐Induced Biomineralization for Accelerated Diabetic Wound Healing | Abstract Chronic wounds in diabetic patients are challenging because their prolonged inflammation makes healing difficult, thus burdening patients, society, and health care systems. Customized dressing materials are needed to effectively treat such wounds that vary in shape and depth. The continuous development of 3D‐p... | 1 Introduction Skin injuries caused by diseases, burns, and other accidents are common wounds. [ 1 ] Generally, acute wounds undergo the following healing stages: initial hemostasis, inflammation, proliferation, and remodeling. [ 2, 3, 4 ] Chronic wounds, in contrast, do not follow these stages; they hardly heal owing ... |
10. 1002/advs. 202300912 | 2,023 | Advanced Science | Synergizing Algorithmic Design, Photoclick Chemistry and Multi‐Material Volumetric Printing for Accelerating Complex Shape Engineering | Abstract The field of biomedical design and manufacturing has been rapidly evolving, with implants and grafts featuring complex 3D design constraints and materials distributions. By combining a new coding‐based design and modeling approach with high‐throughput volumetric printing, a new approach is demonstrated to tran... | 1 Introduction Design complexities in the biomedical domain have been increasing at an exponential pace. This is highly relevant in the field of implants and grafts. Using advanced computer‐aided design (CAD) and computational modeling (CM) tools, complex implants are being developed that offer better mechanics (reduce... |
10. 1002/advs. 202301309 | 2,023 | Advanced Science | Multicellular Bioprinting of Biomimetic Inks for Tendon‐to‐Bone Regeneration | Abstract Tendon‐to‐bone interface has a hierarchical structure and gradient component that are conducive to distributing the stresses to achieve movement. Conventional biomaterials lack the capacity to induce synchronous repair of multiple tissues, resulting in the failure of the interface repair. Biomimetic strategies... | 1 Introduction Soft and hard tissue damage usually occurs simultaneously in severe bone defects, cartilage damage, teeth missing, or tendon injury. [ 1 ] At present, integrated regeneration of soft/hard composite tissues remains an intractable problem in clinics, since the frequent failure of reconstructing complex sof... |
10. 1002/advs. 202301395 | 2,023 | Advanced Science | Alveoli‐Like Multifunctional Scaffolds for Optical and Electrochemical In Situ Monitoring of Cellular Responses from Type II Pneumocytes | Abstract While breathing, alveoli are exposed to external irritants, which contribute to the pathogenesis of lung disease. Therefore, in situ monitoring of alveolar responses to stimuli of toxicants under in vivo environments is important to understand lung disease. For this purpose, 3D cell cultures are recently emplo... | 1 Introduction The alveoli are the main units involved in respiration and are normally filled with air upon inhalation. Due to this, the alveoli are easily exposed to potentially hazardous materials and air pollution. Alveolar diseases are caused by the inhalation of noxious chemical components, such as cigarette smoke... |
10. 1002/advs. 202301489 | 2,023 | Advanced Science | Programmable Acoustic Holography using Medium‐Sound‐Speed Modulation | Abstract Acoustic holography offers the ability to generate designed acoustic fields to manipulate microscale objects. However, the static nature or large aperture sizes of 3D printed acoustic holographic phase plates limits the ability to rapidly alter generated fields. In this work， a programmable acoustic holography... | 1 Introduction Acoustic holography generates designed acoustic fields by modulating the interference of wavefronts in free space, [ 1, 2, 3, 4, 5, 6, 7, 8 ] with emerging applications in cell/tissue engineering, [ 9, 10, 11 ] medical ultrasound, [ 12, 13, 14, 15 ] particle manipulation, [ 16, 17, 18, 19 ] and particle ... |
10. 1002/advs. 202301499 | 2,023 | Advanced Science | Scalable Generation of Pre‐Vascularized and Functional Human Beige Adipose Organoids | Abstract Obesity and type 2 diabetes are becoming a global sociobiomedical burden. Beige adipocytes are emerging as key inducible actors and putative relevant therapeutic targets for improving metabolic health. However, in vitro models of human beige adipose tissue are currently lacking and hinder research into this ce... | 1 Introduction Despite public health initiatives, type 2 diabetes and obesity have reached worldwide pandemic proportions and are associated with the leading cause of death. Both metabolic disorders are characterized by an imbalance between energy intake and energy expenditure. Adipose tissues are key regulators of thi... |
10. 1002/advs. 202301544 | 2,023 | Advanced Science | Deep Learning Empowers the Discovery of Self‐Assembling Peptides with Over 10 Trillion Sequences | Abstract Self‐assembling of peptides is essential for a variety of biological and medical applications. However, it is challenging to investigate the self‐assembling properties of peptides within the complete sequence space due to the enormous sequence quantities. Here, it is demonstrated that a transformer‐based deep ... | 1 Introduction Peptides, which are short chains consisting of normally less than 50 amino acids, have been paid tremendous attention due to their facile synthesis, inherent biodegradability, and biocompatibility, as well as rich chemical diversity for producing stable nanostructures with fluorescence, [ 1 ] semiconduct... |
10. 1002/advs. 202301639 | 2,023 | Advanced Science | A 3D‐Printed Dual Driving Forces Scaffold with Self‐Promoted Cell Absorption for Spinal Cord Injury Repair | Abstract Stem cells play critical roles in cell therapies and tissue engineering for nerve repair. However, achieving effective delivery of high cell density remains a challenge. Here, a novel cell delivery platform termed the hyper expansion scaffold (HES) is developed to enable high cell loading. HES facilitated self... | 1 Introduction Spinal cord injury (SCI) is a serious disease of the central nervous system with more than half a million new cases worldwide reported every year. [ 1, 2 ] The main contributors to poor recovery from SCI are a nonpermissive microenvironment and insufficient replenishment of cells in the lesion. [ 3, 4 ] ... |
10. 1002/advs. 202301665 | 2,023 | Advanced Science | Tough Gelatin Hydrogel for Tissue Engineering | Abstract Tough hydrogel has attracted considerable interest in various fields, however, due to poor biocompatibility, nondegradation, and pronounced compositional differences from natural tissues, it is difficult to be used for tissue regeneration. Here, a gelatin‐based tough hydrogel (GBTH) is proposed to fill this ga... | 1 Introduction Tough hydrogel has been a major research focus in the past decades due to excellent mechanical properties, and it has been commonly used in soft artificial muscles, tissue engineering scaffolds, [ 1 ] flexible electronics, [ 2, 3 ] and other applications. Various methods to produce tough hydrogel have be... |
10. 1002/advs. 202301806 | 2,023 | Advanced Science | Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment | Abstract Bone diseases including bone defects, bone infections, osteoarthritis, and bone tumors seriously affect life quality of the patient and bring serious economic burdens to social health management, for which the current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial‐based strategies ha... | 1 Introduction Bone consisting of bone cells embedded in hierarchical intercellular collagen and calcium phosphate plays an important role in the body structural support, organs protection, and endocrine system and hematopoiesis regulation. [ 1, 2 ] Bone diseases including bone defects, bone infections, osteoarthritis,... |
10. 1002/advs. 202302044 | 2,023 | Advanced Science | Advanced Metallized Nanofibers for Biomedical Applications | Abstract Nanofibers are long, wire‐like materials with nanoscale diameters and specific length diameter ratios. Nanofibers have porous reticular networks with remarkably high specific surface areas and significant interconnectivity between pores, allowing for the chemical modification and loading of drugs. Metallized n... | 1 Introduction Natural fibers, such as cotton, hemp, and silk were used by humans as early as the Neolithic era to cover the body and keep warm. With the development of the chemical and polymer material industries, a series of synthetic polymer fibers have been designed and synthesized; these fibers are not limited to ... |
10. 1002/advs. 202302136 | 2,023 | Advanced Science | Liver‐Inspired Polyetherketoneketone Scaffolds Simulate Regenerative Signals and Mobilize Anti‐Inflammatory Reserves to Reprogram Macrophage Metabolism for Boosted Osteoporotic Osseointegration | Abstract Tissue regeneration is regulated by morphological clues of implants in bone defect repair. Engineered morphology can boost regenerative biocascades that conquer challenges such as material bioinertness and pathological microenvironments. Herein, a correlation between the liver extracellular skeleton morphology... | 1 Introduction Currently, designing efficient strategies to repair bone defects caused by trauma and diseases still faces enormous challenges. [ 1 ] In the field of tissue engineering, the application of bone substitute materials, such as biological scaffolds, represents a promising approach to repairing defects. [ 2 ]... |
10. 1002/advs. 202302327 | 2,023 | Advanced Science | A Hierarchical Mechanotransduction System: From Macro to Micro | Abstract Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including mechanical forces and properties, are sensed and translated into biochemical signals. Increasing data demonstrate that mechanotransduction is crucial for regulating macroscopic and microscopic dynamics and functionalities... | 1 Introduction Over decades, mechanical stimuli have been increasingly illuminated to play important physio‐pathological roles in many creatures’ life processes. [ 1, 2, 3 ] Mechanotransduction is a process whereby creatures sense mechanical stimuli (inputs) and further transduce downstream biochemical responses (outpu... |
10. 1002/advs. 202302411 | 2,023 | Advanced Science | Surface Tension and Neuronal Sorting in Magnetically Engineered Brain‐Like Tissue | Abstract Engineered 3D brain‐like models have advanced the understanding of neurological mechanisms and disease, yet their mechanical signature, while fundamental for brain function, remains understudied. The surface tension for instance controls brain development and is a marker of cell‐cell interactions. Here, 3D mag... | 1 Introduction Human brain in vitro 3D models have since recent years been utilized for recapitulating the properties and physiology of this organ with the purpose of studying brain‐penetrating drugs, [ 1 ] cell‐cell interactions, [ 2 ] brain disease [ 3 ] and neurological disorders. [ 4 ] These models have evolved fro... |
10. 1002/advs. 202302463 | 2,024 | Advanced Science | Practical Applications of Self‐Healing Polymers Beyond Mechanical and Electrical Recovery | Abstract Self‐healing polymeric materials, which can repair physical damage, offer promising prospects for protective applications across various industries. Although prolonged durability and resource conservation are key advantages, focusing solely on mechanical recovery may limit the market potential of these materia... | 1 Introduction Self‐healing polymers have emerged as a groundbreaking area of research in materials science and engineering, owing to their ability to repair damage thereby extending the life cycle of products and reducing plastic waste and costs. [ 1 ] Consequently, self‐healing polymers have attracted considerable at... |
10. 1002/advs. 202302519 | 2,023 | Advanced Science | A Bioinspired Self‐Healing Conductive Hydrogel Promoting Peripheral Nerve Regeneration | Abstract The development of self‐healing conductive hydrogels is critical in electroactive nerve tissue engineering. Typical conductive materials such as polypyrrole (PPy) are commonly used to fabricate artificial nerve conduits. Moreover, the field of tissue engineering has advanced toward the use of products such as ... | 1 Introduction Peripheral nerve injuries (PNI) occur frequently and are a severe clinical condition that can lead to motor or sensory dysfunction, affecting the overall quality of life. [ 1 ] Nerve regeneration is a challenge owing to limited self‐repair capacity. [ 2 ] Nerve tissues are sensitive to electrical signals... |
10. 1002/advs. 202302574 | 2,023 | Advanced Science | Urethral Microenvironment Adapted Sodium Alginate/Gelatin/Reduced Graphene Oxide Biomimetic Patch Improves Scarless Urethral Regeneration | Abstract The nasty urine microenvironment (UME) is an inherent obstacle that hinders urethral repair due to fibrosis and swelling of the oftentimes adopted hydrogel‐based biomaterials. Here, using reduced graphene oxide (rGO) along with double‐freeze‐drying to strengthen a 3D‐printed patch is reported to realize scarle... | 1 Introduction Urethral stricture, which is a narrowing process of urethra lumen caused by fibrosis of the urethra mucosa and the surrounding spongy corpus spongiosum, is often inevitable after urethral injury. [ 1, 2, 3 ] It has been reported that 229 to 627 out of 100 000 males suffer from urethral stricture, but the... |
10. 1002/advs. 202302611 | 2,023 | Advanced Science | Tissue‐Engineered Disease Modeling of Lymphangioleiomyomatosis Exposes a Therapeutic Vulnerability to HDAC Inhibition | Abstract Lymphangioleiomyomatosis (LAM) is a rare disease involving cystic lung destruction by invasive LAM cells. These cells harbor loss‐of‐function mutations in TSC2, conferring hyperactive mTORC1 signaling. Here, tissue engineering tools are employed to model LAM and identify new therapeutic candidates. Biomimetic ... | 1 Introduction Lymphangioleiomyomatosis (LAM) is a cystic lung disease predominately affecting women, at a prevalence of 1 to 10 per million. [ 1 ] LAM can occur sporadically or in association with the multisystem tumor‐forming disorder, tuberous sclerosis complex (TSC). [ 2 ] The pulmonary histopathology is characteri... |
10. 1002/advs. 202302622 | 2,023 | Advanced Science | Exosomal mRNAs for Angiogenic–Osteogenic Coupled Bone Repair | Abstract Regenerative medicine in tissue engineering often relies on stem cells and specific growth factors at a supraphysiological dose. These approaches are costly and may cause severe side effects. Herein, therapeutic small extracellular vesicles (t‐sEVs) endogenously loaded with a cocktail of human vascular endothe... | 1 Introduction Bony injuries (fractures), particularly critical‐size defects are unable to self‐heal and require orthopedic surgery and therapeutics. [ 1 ] Bone tissue engineering (BTE) strategies such as growth factors and stem‐cell therapies have been widely explored in clinical trials. Several growth factors, such a... |
10. 1002/advs. 202302632 | 2,023 | Advanced Science | Electroceuticals for Regeneration of Long Nerve Gap Using Biodegradable Conductive Conduits and Implantable Wireless Stimulator | Abstract Regeneration of over 10 mm long peripheral nerve defects remains a challenge due to the failure of regeneration by prolonged axotomy and denervation occurring in long‐term recovery. Recent studies reveal that conductive conduits and electrical stimulation accelerate the regeneration of long nerve defects. In t... | 1 Introduction Peripheral nerve injury causes the impairment of sensory and motor functions, muscle atrophy, and neurogenic pain, with most cases of severe peripheral damage recovering incompletely. [ 1, 2 ] A completely transected peripheral nerve can be repaired using end‐to‐end neurorrhaphy, but long nerve gaps over... |
10. 1002/advs. 202302637 | 2,023 | Advanced Science | Ultra‐Rapid and Specific Gelation of Collagen Molecules for Transparent and Tough Gels by Transition Metal Complexation | Abstract Collagen is the most abundant protein in the human body and one of the main components of stromal tissues in tumors which have a high elastic modulus of over 50 kPa. Although collagen has been widely used as a cell culture scaffold for cancer cells, there have been limitations when attempting to fabricate a to... | 1 Introduction Extracellular matrices (ECMs) contain/possess/are made of key components for regulating the cell microenvironment, controlling cell functions such as adhesion, migration, growth, differentiation, cell‐cell interaction, protein secretion, and metabolism. [ 1, 2 ] Collagen (Col) is an important fibrillar E... |
10. 1002/advs. 202302702 | 2,023 | Advanced Science | Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds | Abstract Additively manufactured scaffolds offer significant potential for treating bone defects, owing to their porous, customizable architecture and functionalization capabilities. Although various biomaterials have been investigated, metals – the most successful orthopedic material – have yet to yield satisfactory r... | 1 Introduction Bone defects, arising from trauma, infections, or surgical procedures such as tumor resection and craniotomy, continue to present clinical challenges for regeneration. Although bone grafts are a viable treatment option, their clinical application is constrained by surgical risks and donor site morbidity ... |
10. 1002/advs. 202302747 | 2,023 | Advanced Science | Bifunctional MXene‐Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration | Abstract Retinal degeneration, characterized by the progressive loss of retinal neurons, is the leading cause of incurable visual impairment. Retinal progenitor cells (RPCs)‐based transplantation can facilitate sight restoration, but the clinical efficacy of this process is compromised by the imprecise neurogenic diffe... | 1 Introduction Retinal degeneration (RD) refers to a large group of neurodegenerative diseases of the retina, which mainly include retinitis pigmentosa, macular degeneration, retinal dystrophy and diabetic retinopathy, is the most common cause of untreatable blindness. [ 1 ] Although the pathogenesis of RD remains ambi... |
10. 1002/advs. 202302830 | 2,023 | Advanced Science | Metallization of Targeted Protein Assemblies in Cell‐Derived Extracellular Matrix by Antibody‐Guided Biotemplating | Abstract Biological systems are composed of hierarchical structures made of a large number of proteins. These structures are highly sophisticated and challenging to replicate using artificial synthesis methods. To exploit these structures in materials science, biotemplating is used to achieve biocomposites that accurat... | 1 Introduction Biological systems possess highly hierarchical 3D structures made up of a large number of different proteins. These systems exhibit significantly greater levels of structural complexity than man‐made materials, leading to unique properties. [ 1, 2 ] To exploit this complexity for synthesizing functional ... |
10. 1002/advs. 202302874 | 2,023 | Advanced Science | Spatiotemporal Immunomodulation and Biphasic Osteo‐Vascular Aligned Electrospun Membrane for Diabetic Periosteum Regeneration | Abstract Under diabetic conditions, blood glucose fluctuations and exacerbated immunopathological inflammatory environments pose significant challenges to periosteal regenerative repair strategies. Responsive immune regulation in damaged tissues is critical for the immune microenvironment, osteogenesis, and angiogenesi... | 1 Introduction Diabetes mellitus (DM) is a long‐term metabolic disorder that affected ≈425 million people globally in 2017, and the number is estimated to surpass 629 million by 2035. [ 1 ] In addition to well‐known macrovascular and microvascular complications, such as strokes, retinopathy, neuropathy, and nephropathy... |
10. 1002/advs. 202302903 | 2,023 | Advanced Science | Microfluidic‐Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease | Abstract The knowledge of the blood microvasculature and its functional role in health and disease has grown significantly attributable to decades of research and numerous advances in cell biology and tissue engineering; however, the lymphatics (the secondary vascular system) has not garnered similar attention, in part... | 1 Introduction Most human tissues contain a secondary vascular system known as the lymphatics comparable in complexity to their blood vasculature. Both systems serve as an elaborate, hierarchal network of vessels lined by endothelial cells that serve as conduits for fluid, protein, and cellular transport. [ 1 ] However... |
10. 1002/advs. 202302988 | 2,024 | Advanced Science | Remodeling of the Intra‐Conduit Inflammatory Microenvironment to Improve Peripheral Nerve Regeneration with a Neuromechanical Matching Protein‐Based Conduit | Abstract Peripheral nerve injury (PNI) remains a challenging area in regenerative medicine. Nerve guide conduit (NGC) transplantation is a common treatment for PNI, but the prognosis of NGC treatment is unsatisfactory due to 1) neuromechanical unmatching and 2) the intra‐conduit inflammatory microenvironment (IME) resu... | 1 Introduction Peripheral nerve injury (PNI) is a common clinical condition that can result in severe disability and a significant burden on patients and society. [ 1 ] The main causes of the poor prognosis of PNI treatment are interference from surrounding muscle tissue and inflammation. [ 2 ] The main strategy for PN... |
10. 1002/advs. 202303006 | 2,023 | Advanced Science | Laponite Lights Calcium Flickers by Reprogramming Lysosomes to Steer DC Migration for An Effective Antiviral CD8 | Abstract Immunotherapy using dendritic cell (DC)‐based vaccination is an established approach for treating cancer and infectious diseases; however, its efficacy is limited. Therefore, targeting the restricted migratory capacity of the DCs may enhance their therapeutic efficacy. In this study, the effect of laponite (La... | 1 Introduction Dendritic cells (DCs) are the most powerful specialized antigen‐presenting cells, bridging innate and adaptive immunity to activate naïve T cells. [ 1 ] Successful ex vivo generation of DCs from their precursors has ushered in an era of adoptive DC vaccines. [ 2 ] Currently, immunization with functionall... |
10. 1002/advs. 202303033 | 2,023 | Advanced Science | An Intrinsically Magnetic Epicardial Patch for Rapid Vascular Reconstruction and Drug Delivery | Abstract Myocardial infarction (MI) is a major cause of mortality worldwide. The major limitation of regenerative therapy for MI is poor cardiac retention of therapeutics, which results from an inefficient vascular network and poor targeting ability. In this study, a two‐layer intrinsically magnetic epicardial patch (M... | 1 Introduction Myocardial infarction (MI) is the predominant cause of global cardiovascular mortality. [ 1 ] Insufficient blood perfusion to the ischemic zone causes myocardial necrosis and fibrotic scar formation, resulting in ventricular dysfunction and heart failure (HF). [ 2 ] In recent years, with increasing insig... |
10. 1002/advs. 202303078 | 2,023 | Advanced Science | Transition Metal High‐Entropy Nanozyme: Multi‐Site Orbital Coupling Modulated High‐Efficiency Peroxidase Mimics | Abstract Strong substrate affinity and high catalytic efficiency are persistently pursued to generate high‐performance nanozymes. Herein, with unique surface atomic configurations and distinct d‐orbital coupling features of different metal components, a class of highly efficient MnFeCoNiCu transition metal high‐entropy... | 1 Introduction Nanozymes are explicitly defined as a collection of nanomaterial‐based artificial enzyme mimics, and they have gradually evolved as alternatives to natural enzymes due to their outstanding environmental tolerance, recyclability, and long‐term stability. [ 1 ] Since the first accidental discovery of the i... |
10. 1002/advs. 202303215 | 2,023 | Advanced Science | Advances in CAR‐Engineered Immune Cell Generation: Engineering Approaches and Sourcing Strategies | Abstract Chimeric antigen receptor T‐cell (CAR‐T) therapy has emerged as a highly efficacious treatment modality for refractory and relapsed hematopoietic malignancies in recent years. Furthermore, CAR technologies for cancer immunotherapy have expanded from CAR‐T to CAR‐natural killer cell (CAR‐NK), CAR‐cytokine‐induc... | 1 Introduction Recent years have witnessed the emergence and rapid development of CAR technology, and CAR‐T immunotherapy has shown impressive clinical success for refractory and relapsed (r/r) hematopoietic malignancies, including CD19+ leukemia and lymphoma, as well as BCMA+ multiple myeloma. [ 1 ] To date, nine CAR‐... |
10. 1002/advs. 202303228 | 2,023 | Advanced Science | Synthetic Collagen Hydrogels through Symmetric Self‐Assembly of Small Peptides | Abstract Animal‐sourced hydrogels, such as collagen, are widely used as extracellular‐matrix (ECM) mimics in tissue engineering but are plagued with problems of reproducibility, immunogenicity, and contamination. Synthetic, chemically defined hydrogels can avoid such issues. Despite the abundance of collagen in the ECM... | 1 Introduction Except for teeth, nails, and bone, the human body is a hydrogel. [ 1 ] Hydrogels are hydrophilic polymer networks that can retain water at more than 100 times their own weight. [ 2 ] As materials, hydrogels are commonly employed as extracellular matrix (ECM) mimics in tissue engineering and medicine, as ... |
10. 1002/advs. 202303259 | 2,023 | Advanced Science | Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications | Abstract Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways involved in numerous physiological processes (e. g. , vasodilation, neurotransmission, inflammation, apoptosis, and tumor growth). Due to its gaseous form, NO has a short half‐life, and its physiology role is concentration de... | 1 Introduction Nitric oxide (NO) is a ubiquitous gaseous molecule that is water soluble and can pass freely across cell membranes. It has a free radical structure making it notoriously noxious and possesses an extra electron which allows it to be highly reactive. [ 1 ] In the late 1900s, NO was reported as an endotheli... |
10. 1002/advs. 202303291 | 2,023 | Advanced Science | Lepr‐Expressing PDLSCs Contribute to Periodontal Homeostasis and Respond to Mechanical Force by Piezo1 | Abstract Periodontium supports teeth in a mechanically stimulated tissue environment, where heterogenous stem/progenitor populations contribute to periodontal homeostasis. In this study, Leptin receptor+ (Lepr+) cells are identified as a distinct periodontal ligament stem cell (PDLSC) population by single‐cell RNA sequ... | 1 Introduction The periodontium provides attachment and anchorage of teeth in the alveolar bone, while protecting underlying tissues against occlusal trauma. [ 1, 2 ] The periodontal attachment, consisting of cementum covering roots of the teeth, periodontal ligament fibers, and the alveolar bone, share a common develo... |
10. 1002/advs. 202303326 | 2,023 | Advanced Science | Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications | Abstract Hydrogels with tailor‐made swelling‐shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients and metabolites, as well as drug diffusion and release, hydrogels with hi... | 1 Introduction Hydrogels have been the subject of extensive research in a multifaceted range of biomedical fields. They are 3D cross‐linked materials that are capable of retaining a significant fraction of water. [ 1 ] The large water content and porous structure endow the hydrogels a degree of softness resemble natura... |
10. 1002/advs. 202303395 | 2,023 | Advanced Science | Cyclic Stretch Promotes Cellular Reprogramming Process through Cytoskeletal‐Nuclear Mechano‐Coupling and Epigenetic Modification | Abstract Advancing the technologies for cellular reprogramming with high efficiency has significant impact on regenerative therapy, disease modeling, and drug discovery. Biophysical cues can tune the cell fate, yet the precise role of external physical forces during reprogramming remains elusive. Here the authors show ... | 1 Introduction Cells sense the physical properties of their microenvironment and translate them into biochemical signals to regulate their functions and behaviors. [ 1 ] This process, called mechanotransduction, is critical in a wide range of pathophysiological conditions, including development, wound healing, and canc... |
10. 1002/advs. 202303637 | 2,023 | Advanced Science | Double‐Network DNA Macroporous Hydrogel Enables Aptamer‐Directed Cell Recruitment to Accelerate Bone Healing | Abstract Recruiting endogenous bone marrow mesenchymal stem cells (BMSCs) in vivo to bone defect sites shows great promise in cell therapies for bone tissue engineering, which tackles the shortcomings of delivering exogenous stem cells, including limited sources, low retention, stemness loss, and immunogenicity. Howeve... | 1 Introduction As a highly mineralized connective tissue, bone injuries can lead to severe pain and disability, and bone tissue reconstruction is still facing considerable challenges. Tissue engineering method of integrating cells, signaling molecules, and/or biological materials to repair damaged tissues has provided ... |
10. 1002/advs. 202303650 | 2,023 | Advanced Science | 3D Printing of Microenvironment‐Specific Bioinspired and Exosome‐Reinforced Hydrogel Scaffolds for Efficient Cartilage and Subchondral Bone Regeneration | Abstract In clinical practice, repairing osteochondral defects presents a challenge due to the varying biological properties of articular cartilages and subchondral bones. Thus, elucidating how spatial microenvironment‐specific biomimetic scaffolds can be used to simultaneously regenerate osteochondral tissue is an imp... | 1 Introduction Articular chondral lesions are present in >60% of patients that undergo arthroscopy. [ 1, 2 ] Cartilage has a limited self‐healing capacity due to its avascular nature and low cellularity. Articular cartilage tissues connect articular surfaces to subchondral bones. In clinical situations, cartilage damag... |
10. 1002/advs. 202303707 | 2,023 | Advanced Science | Calming the Nerves via the Immune Instructive Physiochemical Properties of Self‐Assembling Peptide Hydrogels | Abstract Current therapies for the devastating damage caused by traumatic brain injuries (TBI) are limited. This is in part due to poor drug efficacy to modulate neuroinflammation, angiogenesis and/or promoting neuroprotection and is the combined result of challenges in getting drugs across the blood brain barrier, in ... | 1 Introduction Due to a lack of effective treatments, traumatic brain injury (TBI) is one of the leading causes of long‐term disability and death worldwide, resulting in an enormous socio‐economic burden to patients, patients’ families and broader society. [ 1, 2 ] TBI has a complex prognosis, as it includes any physic... |
10. 1002/advs. 202303818 | 2,023 | Advanced Science | Multi‐Bioinspired MOF Delivery Systems from Microfluidics for Tumor Multimodal Therapy | Abstract Metal–organic framework (MOF)‐based drug delivery systems have demonstrated values in oncotherapy. Current research endeavors are centralized on the functionality enrichment of featured MOF materials with designed versatility for synergistic multimodal treatments. Here, inspired by the multifarious biological ... | 1 Introduction Cancer is a leading cause of death worldwide, seriously threatening human health. [ 1 ] Chemotherapy, as one of the main traditional therapy methods, has been largely indispensable in cancer treatment. [ 2 ] Typically, platinum‐based chemotherapeutics (cisplatin, oxaliplatin, carboplatin, etc. ) are wide... |
10. 1002/advs. 202303819 | 2,023 | Advanced Science | Enhanced Chemo‐Immunotherapy Strategy Utilizing Injectable Thermosensitive Hydrogel for The Treatment of Diffuse Peritoneal Metastasis in Advanced Colorectal Cancer | Abstract Patients with colorectal cancer (CRC) and diffuse peritoneal metastasis (PM) are not eligible for surgical intervention. Thus, palliative treatment remains the standard of care in clinical practice. Systemic chemotherapy fails to cause drug accumulation at the lesion sites, while intraperitoneal chemotherapy (... | 1 Introduction Colorectal cancer (CRC) is the most prevalent malignant tumor of the digestive system and is characterized by high morbidity and mortality rates. [ 1 ] The low early diagnosis rate of CRC can be attributed to ambiguous abdominal symptoms and a lack of endoscopic resources. [ 2 ] At the initial diagnosis,... |
10. 1002/advs. 202303907 | 2,023 | Advanced Science | Erythrocyte‐Leveraged Oncolytic Virotherapy (ELeOVt): Oncolytic Virus Assembly on Erythrocyte Surface to Combat Pulmonary Metastasis and Alleviate Side Effects | Abstract Despite being a new promising tool for cancer therapy, intravenous delivery of oncolytic viruses (OVs) is greatly limited by poor tumor targeting, rapid clearance in the blood, severe organ toxicity, and cytokine release syndrome. Herein, a simple and efficient strategy of erythrocyte‐leveraged oncolytic virot... | 1 Introduction Cancer has been a major threat to public health worldwide and one of the leading causes of death over the past few decades. [ 1 ] Although the early detection, diagnosis, and treatment of cancer, the popular application of various cancer screening methods, as well as the close observation and follow‐up o... |
10. 1002/advs. 202303958 | 2,023 | Advanced Science | Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration | Abstract Owing to their mechanical resilience and non‐toxicity, titanium implants are widely applied as the major treatment modality for the clinical intervention against bone fractures. However, the intrinsic bioinertness of Ti and its alloys often impedes the effective osseointegration of the implants, leading to sev... | 1 Introduction Bone fracture is the most common injuries in daily life. [ 1 ] Although some minor structural damage to the bone mass could be healed in a spontaneous manner on account of the regenerative property of bone tissues, [ 2 ] there are many circumstances that require the implementation of orthopedic implants ... |
10. 1002/advs. 202304023 | 2,023 | Advanced Science | Adipose‐Derived Mesenchymal Stem Cell‐Derived Exosomes Biopotentiated Extracellular Matrix Hydrogels Accelerate Diabetic Wound Healing and Skin Regeneration | Abstract Wound healing is an urgent clinical challenge, particularly in the case of chronic wounds. Traditional approaches to wound healing have limited therapeutic efficacy due to lengthy healing times, risk of immune rejection, and susceptibility to infection. Recently, adipose‐derived mesenchymal stem cell‐derived e... | 1 Introduction As the largest organ of the human body, the skin is composed of various cells and maintains homeostasis. [ 1 ] Wound healing is essential in maintaining and restoring epidermal barrier integrity after skin damage. [ 2 ] In general, wound healing experiences four typical stages, including hemostasis, infl... |
10. 1002/advs. 202304040 | 2,023 | Advanced Science | Cell Surface Engineering Tools for Programming Living Assemblies | Abstract Breakthroughs in precision cell surface engineering tools are supporting the rapid development of programmable living assemblies with valuable features for tackling complex biological problems. Herein, the authors overview the most recent technological advances in chemically‐ and biologically‐driven toolboxes ... | 1 Introduction The mammalian cell surface is a complex frontier that plays a central role in modifying cellular behavior and physiological processes. [ 1 ] Being comprised of a plethora of lipids, proteins, and glycans that carry surface ligands and receptors, the cell surface receives and responds to various stimuli t... |
10. 1002/advs. 202304090 | 2,023 | Advanced Science | Macroporous Granular Hydrogels Functionalized with Aligned Architecture and Small Extracellular Vesicles Stimulate Osteoporotic Tendon‐To‐Bone Healing | Abstract Osteoporotic tendon‐to‐bone healing (TBH) after rotator cuff repair (RCR) is a significant orthopedic challenge. Considering the aligned architecture of the tendon, inflammatory microenvironment at the injury site, and the need for endogenous cell/tissue infiltration, there is an imminent need for an ideal sca... | 1 Introduction Rotator cuff injury is one of the most common musculoskeletal disorders, and its incidence increases with age. Massive rotator cuff tears affect 25% of people over the age of 60% and 50% of people over the age of 80. [ 1 ] It is estimated that ≈250 000 rotator cuff repair (RCR) surgeries are performed ea... |
10. 1002/advs. 202304110 | 2,023 | Advanced Science | Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine | Abstract Bioelectricity is the electrical activity that occurs within living cells and tissues. This activity is critical for regulating homeostatic cellular function and communication, and disruptions of the same can lead to a variety of conditions, including cancer. Cancer cells are known to exhibit abnormal electric... | 1 Introduction Cancer is a complex disease that affects millions of people worldwide. [ 1 ] Despite advances in cancer research and treatment, cancer remains one of the leading causes of death globally. [ 2 ] In recent years, there has been a growing interest in exploring the role of bioelectricity in cancer. [ 3, 4, 5... |
10. 1002/advs. 202304124 | 2,023 | Advanced Science | Microneedle‐Mediated Cell Therapy | Abstract Microneedles have emerged as a promising platform for transdermal drug delivery with prominent advantages, such as enhanced permeability, mitigated pain, and improved patient adherence. While microneedles have primarily been employed for delivering small molecules, nucleic acids, peptides, and proteins, recent... | 1 Introduction Microneedle (MN)‐based transdermal delivery systems have attracted increasing interest as an alternative to conventional administration such as oral and parenteral routes over the past decades. [ 1, 2 ] By physically penetrating the stratum corneum barrier to generate micropores, MNs facilitate the effic... |
10. 1002/advs. 202304160 | 2,023 | Advanced Science | Engineering Heterogeneous Tumor Models for Biomedical Applications | Abstract Tumor tissue engineering holds great promise for replicating the physiological and behavioral characteristics of tumors in vitro. Advances in this field have led to new opportunities for studying the tumor microenvironment and exploring potential anti‐cancer therapeutics. However, the main obstacle to the wide... | 1 Introduction Tumor development often leads to heterogeneities that can cause difficulties in oncology research and clinical treatments. [ 1, 2, 3, 4 ] In recent decades, attention has been paid to tumor heterogeneity to facilitate the development of mechanism studying and therapy discovering. [ 5, 6, 7 ] From an anal... |
10. 1002/advs. 202304190 | 2,023 | Advanced Science | Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration | Abstract The development of bioactive scaffolds by mimicking bone tissue extracellular matrix is promising for bone regeneration. Herein, inspired by the bone tissue composition, a novel pearl powder (PP) hybrid fish gelatin methacrylate (GelMa) hydrogel scaffold loaded with vascular endothelial growth factor (VEGF) fo... | 1 Introduction The bone defect caused by trauma, infection, tumor, and osteomyelitis is a common orthopedic disease. [ 1, 2 ] Especially, large bone defects, where defected area exceeds the critical state for autologous repair, cannot heal spontaneously with organic stimulation and could result in bone resorption, oste... |
10. 1002/advs. 202304216 | 2,023 | Advanced Science | Biomimetic Intrafibrillar Mineralization of Native Tendon for Soft–Hard Interface Integration by Infiltration of Amorphous Calcium Phosphate Precursors | Abstract Soft and hard tissues possess distinct biological properties. Integrating the soft‐hard interface is difficult due to the inherent non‐osteogenesis of soft tissue, especially of anterior cruciate ligament and rotator cuff reconstruction. This property makes it difficult for tendons to be mineralized and integr... | 1 Introduction Regenerating the tendon‐bone junction remains a persistent challenge due to its complex hierarchical gradient structure, which comprises the tendon, non‐calcified fibrocartilage, calcified fibrocartilage, and bone tissue. [ 1 ] The gradient transition of these four components provides for the smooth tran... |
10. 1002/advs. 202304332 | 2,023 | Advanced Science | Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy | Abstract Microfluidic 3D cell culture devices that enable the recapitulation of key aspects of organ structures and functions in vivo represent a promising preclinical platform to improve translational success during drug discovery. Essential to these engineered devices is the spatial patterning of cells from different... | 1 Introduction Despite the significant investment in research and development over the past decade, the annual approval rate for new drugs has remained largely static. [ 1 ] A major contributor to the impasse is the low rate of successful translation from preclinical studies to clinical development. Human organ chips a... |
10. 1002/advs. 202304460 | 2,023 | Advanced Science | Prediction of Clinical Precision Chemotherapy by Patient‐Derived 3D Bioprinting Models of Colorectal Cancer and Its Liver Metastases | Abstract Methods accurately predicting the responses of colorectal cancer (CRC) and colorectal cancer liver metastasis (CRLM) to personalized chemotherapy remain limited due to tumor heterogeneity. This study introduces an innovative patient‐derived CRC and CRLM tumor model for preclinical investigation, utilizing 3d‐b... | 1 Introduction Colorectal cancer (CRC) is a lethal cancer with a high fatality rate worldwide. [ 1 ] Approximately 2 million people suffer from this cancer, with almost 900 000 deaths related to CRC occurring annually, with a growing trend in some countries. [ 2, 3 ] Due to limitations in early diagnosis, a significant... |
10. 1002/advs. 202304480 | 2,023 | Advanced Science | Decoding Macrophage Subtypes to Engineer Modulating Hydrogels for the Alleviation of Intervertebral Disk Degeneration | Abstract A major pathological basis for low back pain is intervertebral disk degeneration, which is primarily caused by the degeneration of nucleus pulposus cells due to imbalances in extracellular matrix (ECM) anabolism and catabolism. The phenotype of macrophages in the local immune microenvironment greatly influence... | 1 Introduction Intervertebral disk (IVD) degeneration (IVDD) is a major pathological basis for low back pain. [ 1, 2 ] IVDs are composed of cartilaginous endplates, external annulus fibrosus (AF), and nucleus pulposus (NP), where the NP is highly hydrated and capable of maintaining IVD height and uniform load transfer ... |
10. 1002/advs. 202304506 | 2,023 | Advanced Science | Functional PDMS Elastomers: Bulk Composites, Surface Engineering, and Precision Fabrication | Abstract Polydimethylsiloxane (PDMS)—the simplest and most common silicone compound—exemplifies the central characteristics of its class and has attracted tremendous research attention. The development of PDMS‐based materials is a vivid reflection of the modern industry. In recent years, PDMS has stood out as the mater... | 1 Introduction Silicone, also known as polysiloxane, is a synthetic polymer with backbone chains of alternating Si and O atoms. Silicone is a chemically inert, thermally stable substance with excellent water and oxidation resistance. It is used in a wide range of products, such as everyday chemicals, sealants, and biom... |
10. 1002/advs. 202304632 | 2,023 | Advanced Science | Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming | Abstract Polylactide (PLA) is the most widely utilized biopolymer in medicine. However, chronic inflammation and excessive fibrosis resulting from its degradation remain significant obstacles to extended clinical use. Immune cell activation has been correlated to the acidity of breakdown products, yet methods to neutra... | 1 Introduction Polylactide (PLA) is the most widely utilized biopolymer, [ 1 ] with applications in nanotechnology, drug delivery, and adult reconstructive surgery for tissue regeneration. However, after surgical implantation, PLA elicits adverse immune responses in up to 44% of human patients, often requiring further ... |
10. 1002/advs. 202304641 | 2,023 | Advanced Science | Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy | Abstract The treatment of bone defects remains a substantial clinical challenge due to the lack of spatiotemporal management of the immune microenvironment, revascularization, and osteogenic differentiation. Herein, deferoxamine (DFO)‐loaded black phosphorus nanosheets decorated by polydopamine layer are prepared (BPPD... | 1 Introduction With the increase in the aging population, the incidence of bone fractures and orthopedic‐related injuries is rising every year, resulting in enormous medical and economic burdens as well as impaired quality of life. [ 1 ] Generally, the regeneration of damaged bone tissue, especially for large bone defe... |
10. 1002/advs. 202304761 | 2,023 | Advanced Science | Enzymatically Bioactive Nucleus Pulposus Matrix Hydrogel Microspheres for Exogenous Stem Cells Therapy and Endogenous Repair Strategy to Achieve Disc Regeneration | Abstract Exogenous stem cell therapy and endogenous repair has shown great potential in intervertebral disc regeneration. However, limited nutrients and accumulation of lactate largely impair the survival and regenerative capacity of implanted stem cells and endogenous nucleus pulposus cells (NPCs). Herein, an injectab... | 1 Introduction Low back pain (LBP) is the leading cause of health conditions that contribute to the need for rehabilitation services worldwide. [ 1 ] Intervertebral disc (IVD) degeneration (IDD), a primary pathological contributor to LBP, is expected to emerge on a larger scale with global aging, imposing tremendous ec... |
10. 1002/advs. 202304861 | 2,024 | Advanced Science | Injectable and Self‐Curing Single‐Component Hydrogel for Stem Cell Encapsulation and In Vivo Bone Regeneration | Abstract An ideal hydrogel for stem cell therapy would be injectable and efficiently promote stem cell proliferation and differentiation in body. Herein, an injectable, single‐component hydrogel with hyaluronic acid (HA) modified with phenylboronic acid (PBA) and spermidine (SM) is introduced. The resulting HAps (HA‐PB... | 1 Introduction A hydrogel is a 3D network containing water that has been used for various biomedical applications, including as a drug depot, filler, adhesive, and coating material. [ 1 ] In particular, hydrogel‐based cell scaffolds have been reported to greatly increase the efficacy of cell therapy, and thus have been... |
10. 1002/advs. 202304989 | 2,024 | Advanced Science | The Evolution of Technology‐Driven In Vitro Models for Neurodegenerative Diseases | Abstract The alteration in the neural circuits of both central and peripheral nervous systems is closely related to the onset of neurodegenerative disorders (NDDs). Despite significant research efforts, the knowledge regarding NDD pathological processes, and the development of efficacious drugs are still limited due to... | 1 Introduction Neurodegenerative diseases (NDDs) represent an umbrella term that includes more than 600 types of nervous system disorders, involving the central nervous system (CNS) as well as the peripheral nervous system (PNS). These conditions are defined by increasing loss of structure and function of neurons and, ... |
10. 1002/advs. 202305201 | 2,023 | Advanced Science | Smart Aqueous Zinc Ion Battery: Operation Principles and Design Strategy | Abstract The zinc ion battery (ZIB) as a promising energy storage device has attracted great attention due to its high safety, low cost, high capacity, and the integrated smart functions. Herein, the working principles of smart responses, smart self‐charging, smart electrochromic as well as smart integration of the bat... | 1 Introduction Intelligent electronic devices such as wearable electronics, intelligent displays and electronic skins have been widely spread and used in modern society. [ 1, 2, 3, 4, 5 ] Recently, it is in great demand for achieving smart electronic devices by functionally adjusting the chemical or physical properties... |
10. 1002/advs. 202305405 | 2,023 | Advanced Science | Facile General Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks Remodel Wound Microenvironment and Accelerate Healing | Abstract Treating the most widespread complication of diabetes: diabetic wounds poses a significant clinical obstacle due to the intricate nature of wound healing in individuals with diabetes. Here a novel approach is proposed using easily applicable injectable gelatin/metal/tea polyphenol double nanonetworks, which ef... | 1 Introduction Diabetic wounds are the most widespread complication of diabetes and have affected more than 34 million people in USA and 55 million patients worldwide and is predicted to affect more than 80 million by 2030. [ 1, 2, 3, 4 ] These wounds are characterized by their chronicity, impaired blood vessel formati... |
10. 1002/advs. 202305508 | 2,023 | Advanced Science | Hydrogel Crosslinked with Nanoparticles for Prevention of Surgical Hemorrhage and Recurrence of Hepatocellular Carcinoma | Abstract Hepatocellular carcinoma (HCC) is acknowledged as an immunosuppressive neoplasm, whereby the inactive microenvironment facilitates immune tolerance and evasion of HCC. Post‐surgical resected liver cancer exhibits a proclivity for relapse, rendering prevention of recurrence challenging as it may transpire at an... | 1 Introduction The global incidence of hepatocellular carcinoma (HCC) is increasing. [ 1 ] Contemporary medical advancements have led to a diverse range of treatment options for liver cancer, predominantly encompassing surgical interventions, liver transplantation, ablation techniques, interventional therapy, radiation... |
10. 1002/advs. 202305756 | 2,024 | Advanced Science | Programmable Electro‐Assembly of Collagen: Constructing Porous Janus Films with Customized Dual Signals for Immunomodulation and Tissue Regeneration in Periodontitis Treatment | Abstract Currently available guided bone regeneration (GBR) films lack active immunomodulation and sufficient osteogenic ability‐ in the treatment of periodontitis, leading to unsatisfactory treatment outcomes. Challenges remain in developing simple, rapid, and programmable manufacturing methods for constructing bioact... | 1 Introduction Periodontitis represents a prevalent chronic inflammatory disease. Persistent inflammation of periodontal tissues leads to severe destruction of the supporting structures, including the alveolar bone (AB), periodontal ligament, and cementum, eventually resulting in tooth loss. [ 1 ] The primary treatment... |
10. 1002/advs. 202305867 | 2,023 | Advanced Science | Coupling of Perinuclear Actin Cap and Nuclear Mechanics in Regulating Flow‐Induced Yap Spatiotemporal Nucleocytoplasmic Transport | Abstract Mechanical forces, including flow shear stress, govern fundamental cellular processes by modulating nucleocytoplasmic transport of transcription factors like Yes‐associated Protein (YAP). However, the underlying mechanical mechanism remains elusive. In this study, it is reported that unidirectional flow induce... | 1 Introduction Living cells are constantly subjected to distinct mechanical cues, such as matrix viscoelasticity, [ 1 ] compressive forces, [ 2 ] and flow shear stress. [ 3 ] These forces are transmitted to the nucleus through the cytoskeleton, causing nuclear deformation and regulating the nucleocytoplasmic transport ... |
10. 1002/advs. 202305918 | 2,023 | Advanced Science | Glycosaminoglycans’ Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials | Abstract Glycosaminoglycans (GAGs) are important for the occurrence of signaling molecules and maintenance of microenvironment within the extracellular matrix (ECM) in living tissues. GAGs and GAG‐based biomaterial approaches have been widely explored to promote in situ tissue regeneration and repair by regulating the ... | 1 Introduction Wound healing, a multifaceted biological process, requires a highly coordinated immune response, cellular proliferation and differentiation, and tissue morphogenesis. [ 1 ] However, various complex and unfavorable wound microenvironments of the repair process may lead to delayed wound healing and poor he... |
10. 1002/advs. 202306035 | 2,024 | Advanced Science | Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications | Abstract Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in t... | 1 Introduction 2D‐structured nanomaterials have gained significant attention from the scientific community due to their unique physicochemical properties, including a high surface‐to‐volume ratio, surface functionalization, distinct shape and variable nano‐length sizes, adjustable mechanical properties, and high anisot... |
10. 1002/advs. 202306152 | 2,023 | Advanced Science | Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy | Abstract Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, the efficient treatment of inflammation has always been the hot topic in the research of medicine. In the past decades, as a potential biomate... | 1 Introduction Inflammation is an internal defensive response induced by immune cells and cytokines, which aimed at repairing injured tissues and clearing various damage factors such as pathogens. Any factor leads to cell or tissue damage could cause inflammations. [ 1 ] Normally, the procedures of inflammation are as ... |
10. 1002/advs. 202306210 | 2,023 | Advanced Science | Mechanical Intercellular Communication via Matrix‐Borne Cell Force Transmission During Vascular Network Formation | Abstract Intercellular communication is critical to the formation and homeostatic function of all tissues. Previous work has shown that cells can communicate mechanically via the transmission of cell‐generated forces through their surrounding extracellular matrix, but this process is not well understood. Here, mechanic... | 1 Introduction The ability of cells to communicate and coordinate their activity is crucial to the development and homeostatic function of all tissues, and as such, holds high relevance to tissue engineering. [ 1 ] Intercellular communication through receptor‐ligand interactions at cell‐cell interfaces or via diffusive... |
10. 1002/advs. 202306246 | 2,023 | Advanced Science | X‐Ray Visible Protein Scaffolds by Bulk Iodination | Abstract Protein‐based biomaterial use is expanding within medicine, together with the demand to visualize their placement and behavior in vivo. However, current medical imaging techniques struggle to differentiate between protein‐based implants and surrounding tissue. Here a fast, simple, and translational solution fo... | 1 Introduction The use of protein‐based biomaterials is widespread in surgery and regenerative medicine. [ 1, 2 ] Among these collagen is predominant, [ 3 ] with established and emerging clinical applications in repairing urogenital damage, skin wounds, bone defects, hernia, cardio‐vascular disease, and in surgical rec... |
10. 1002/advs. 202306428 | 2,023 | Advanced Science | Three Birds, One Stone: An Osteo‐Microenvironment Stage‐Regulative Scaffold for Bone Defect Repair through Modulating Early Osteo‐Immunomodulation, Middle Neovascularization, and Later Osteogenesis | Abstract In order to repair critical‐sized bone defects, various polylactic acid‐glycolic acid (PLGA)‐based hybrid scaffolds are successfully developed as bone substitutes. However, the byproducts of these PLGA‐based scaffolds are known to acidify the implanted site, inducing tiresome acidic inflammation. Moreover, the... | 1 Introduction Critical‐sized bone defects caused by trauma and other bone diseases are difficult to achieve functional restoration without surgical intervention. [ 1 ] In clinics, autologous bone graft from a patient's ilium is regarded as the gold standard for bone defect treatment, but donor‐site morbidity, limited ... |
10. 1002/advs. 202306470 | 2,023 | Advanced Science | Diffusion‐Based 3D Bioprinting Strategies | Abstract 3D bioprinting has enabled the fabrication of tissue‐mimetic constructs with freeform designs that include living cells. In the development of new bioprinting techniques, the controlled use of diffusion has become an emerging strategy to tailor the properties and geometry of printed constructs. Specifically, t... | 1 Introduction The demand for highly specific in vitro models of human tissues, as well as tissue replacements for regenerative medicine, has necessitated new techniques to fabricate constructs recapitulating the structure and function of native tissues. As an extension of conventional additive manufacturing or 3D prin... |
10. 1002/advs. 202306507 | 2,024 | Advanced Science | Injectable “Homing‐Like” Bioactive Short‐Fibers for Endometrial Repair and Efficient Live Births | Abstract The prevalence of infertility caused by endometrial defects is steadily increasing, posing a significant challenge to women's reproductive health. In this study, injectable “homing‐like” bioactive decellularized extracellular matrix short‐fibers (DEFs) of porcine skin origin are innovatively designed for endom... | 1 Introduction Infertility has become a non‐negligible public health issue, and been estimated to affect ≈15% of the global population. [ 1, 2 ] An embryo‐receptive endometrium is one of the key determinants of a successful pregnancy. [ 3, 4, 5 ] Various factors, such as infection and intrauterine surgery, can lead to ... |
10. 1002/advs. 202306528 | 2,023 | Advanced Science | Hydro‐Sensitive, In Situ Ultrafast Physical Self‐Gelatinizing, and Red Blood Cells Strengthened Hemostatic Adhesive Powder with Antibiosis and Immunoregulation for Wound Repair | Abstract Immediate and effective hemostatic treatments for complex bleeding wounds are an urgent clinical demand. Hemostatic materials with characteristics of adhesion, sealing, anti‐infection, and concrescence promotion have drawn growing concerns. However, pure natural multifunctional hemostatic materials with in sit... | 1 Introduction Acute, excessive bleeding, associated with high mortality, is a serious complication during major trauma or surgery scenarios, sometimes bringing about organ failure and hemorrhagic shock. Immediate and effective hemostatic treatments are necessary to prevent life‐threatening emergencies, due to the unba... |
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