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39808695 | Tb-based Metal-Organic Framework-Referenced Fluorescence Assay for Distinguishing Hydroquinone from Its Isomers and Subsequent Quantitative Visual Detection of Cu<sup>2</sup>. | Hydroquinone (HQ) and copper ions (Cu<sup>2+</sup>) are categorized as environmental pollutants that are severely limited in water. Designing a selective assay for discriminating HQ from its two isomers and the convenient determination of Cu<sup>2+</sup> is of great importance. Herein, a Tb-based metal-organic framewor... |
39808679 | Does curcumin supplementation affect inflammation, blood count and serum brain-derived neurotropic factor concentration in amateur long-distance runners? | Curcumin is known for its potential health benefits; however, the evidence remains inconclusive regarding its necessity as a supplement for athletes during the preparatory phase of training. This study aimed to assess the effect of 6-week curcumin supplementation at a dose of 2g/day on selected inflammatory markers, bl... |
39808654 | The <i>Aedes aegypti</i> mosquito evolves two types of prophenoloxidases with diversified functions. | Insect phenoloxidase, presented as an inactive precursor prophenoloxidase (PPO) in hemolymph, catalyzes melanin formation, which is involved in wound healing, pathogen killing, reversible oxygen collection during insect respiration, and cuticle and eggshell formation. Mosquitoes possess 9 to 16 PPO members across diffe... |
39808649 | Fracture-healing effects of Rhizoma Musae ethanolic extract: An integrated study using UHPLC-Q-Exactive-MS/MS, network pharmacology, and molecular docking. | <h4>Background</h4>Fracture disrupts the integrity and continuity of the bone, leading to symptoms such as pain, tenderness, swelling, and bruising. Rhizoma Musae is a medicinal material frequently utilized in the Miao ethnic region of Guizhou Province, China. However, its specific mechanism of action in treating fract... |
39808585 | Context-Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides. | Despite their critical role in context-dependent interactions for protein functions, intrinsically disordered regions (IDRs) are often overlooked for designing peptide assemblies. Here, we exploit IDRs to enable context-dependent heterotypic assemblies of intrinsically disordered peptides, where "context-dependent" ref... |
39808342 | Targeting CHEK1: Ginsenosides-Rh2 and Cu2O@G-Rh2 nanoparticles in thyroid cancer. | Thyroid cancer (THCA) is an increasingly common malignant tumor of the endocrine system, with its incidence rising steadily in recent years. For patients who experience recurrence or metastasis, treatment options are relatively limited, and the prognosis is poor. Therefore, exploring new therapeutic strategies has beco... |
39808283 | A comprehensive study of the influence of non-covalent interactions on electron density redistribution during the reaction between acetic acid and methylamine. | <h4>Context</h4>A chemical reaction can be described, from a physicochemical perspective, as a redistribution of electron density. Additionally, non-covalent interactions locally modify the electron density distribution. This study aims to characterize the modification of reactivity caused by the presence of non-covale... |
39808260 | Recent advances in electrochemical sensing and remediation technologies for ciprofloxacin. | Ciprofloxacin (CIP) is an extensively used broad-spectrum, fluoroquinolone antibiotic used for treating diverse bacterial infections. Effluent treatment plants (ETPs) worldwide lack technologies to detect or remediate antibiotics. CIP reaches the aquatic phase primarily due to inappropriate disposal practices, lack of ... |
39808206 | Electrochemical aptasensor based on zirconium/copper oxides embedded in mesoporous carbon derived from bimetallic metal-organic framework for ultrasensitive detection of miR-21. | A novel electrochemical aptasensor based on bimetallic zirconium and copper oxides embedded within mesoporous carbon (denoted as ZrO<sub>2</sub>CuO<sub>x</sub>@mC) was constructed to detect miRNA. The porous ZrO<sub>2</sub>CuO<sub>x</sub>@mC was created through the pyrolysis of bimetallic zirconium/copper-based metal-o... |
39808195 | Fracture liaison service (FLS) is associated with lower subsequent fragility fracture risk and mortality: NoFRACT (the Norwegian capture the fracture initiative). | Subsequent fracture rates and associated mortality were compared before and after the introduction of fracture liaison service (FLS). In 100,198 women and men, FLS was associated with 13% and 10% lower risk of subsequent fragility fractures and 18% and 15% lower mortality. The study suggests that FLS may prevent fractu... |
39808180 | Confinement-Induced Self-Assembly of Protein Nanofibrils Probed by Microfocus X-ray Scattering. | We here explore confinement-induced assembly of whey protein nanofibrils (PNFs) into microscale fibers using microfocused synchrotron X-ray scattering. Solvent evaporation aligns the PNFs into anisotropic fibers, and the process is followed in situ by scattering experiments within a droplet of PNF dispersion. We find a... |
39807849 | Solid-State Nuclear Magnetic Resonance Spectroscopy for Surface Characterization of Metal Oxide Nanoparticles: State of the Art and Perspectives. | Metal oxide materials have found wide applications across diverse fields; in most cases, their functionalities are dictated by their surface structures and properties. A comprehensive understanding of the intricate surface features is critical for their further design, optimization, and applications, necessitating mult... |
39807682 | Unveiling the Role Reversal of Guest and Host in OverTolerant Hybrid Perovskites. | The structural and electronic changes are investigated in a 3D hybrid perovskite, methylhydrazinium lead chloride (MHyPbCl<sub>3</sub>) from a host/guest perspective as it transitions from a highly polar to less polar phase upon cooling, using first-principles calculations. The two phases vary structurally in the guest... |
39807672 | Comprehensive Chemical Analysis of the Methyl 3-Nitrogen-2,3-Dideoxysaccharides Derivatives with d-<i>ribo</i>-Configuration: Synthesis, Reactivity of HIV-1 Reverse Transcriptase Inhibitors. | This study extends previous research, particularly focusing on patented scientific objects No. ID: PL 240 353 B1, investigating the physicochemical properties of the methyl 3-azido- and 3-amino-2,3-dideoxysaccharides with a nucleoside scaffold similar to 3'-azidothymidine (AZT). The study utilizes multiwavelength spect... |
39807574 | Quantifying Magnetic Anisotropy of Series of Five-Coordinate Co<sup>II</sup> Ions: Experimental and Theoretical Insights. | Stabilizing large easy-axis type magnetic anisotropy in molecular complexes is a challenging task, yet it is crucial for the development of information storage devices and applications in molecular spintronics. Achieving this requires a deep understanding of electronic structure and the relationships between structure ... |
39807563 | Discovery of Peptidic Siderophore Degradation by Screening Natural Product Profiles in Marine-Derived Bacterial Mono- and Cocultures. | Coral reefs are hotspots of marine biodiversity, which results in the synthesis of a wide variety of compounds with unique molecular scaffolds, and bioactivities, rendering reefs an ecosystem of interest. The chemodiversity stems from the intricate relationships between inhabitants of the reef, as the chemistry produce... |
39807075 | Electron-Rich Heptacyclic S,N Heteroacene Enabling C-Shaped A-D-A-type Electron Acceptors With Photoelectric Response beyond 1000 Nm for Highly Sensitive Near-Infrared Photodetectors. | A highly electron-rich S,N heteroacene building block is developed and condensed with FIC and Cl-IC acceptors to furnish CT-F and CT-Cl, which exhibit near-infrared (NIR) absorption beyond 1000 nm. The C-shaped CT-F and CT-Cl self-assemble into a highly ordered 3D intermolecular packing network via multiple π-π interac... |
39807033 | Nanotherapy for Neural Retinal Regeneration. | Retinal diseases can severely impair vision and even lead to blindness, posing significant threats to both physical and mental health. Physical retinal regenerative therapies are poised to revolutionize the treatment of various disorders associated with blindness. However, these therapies must overcome the challenges p... |
39807014 | Ultramicroporous Tröger's Base Framework Membranes With Ionized Sub-nanochannels for Efficient Acid/Alkali Recovery. | Membrane technology holds significant potential for the recovery of acids and alkalis from industrial wastewater systems, with ion exchange membranes (IEMs) playing a crucial role in these applications. However, conventional IEMs are limited to separating only monovalent cations or anions, presenting a significant chal... |
39807013 | Scale-free Spatio-temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins. | The self-assembly of intrinsically disordered proteins (IDPs) into condensed phases and the formation of membrane-less organelles (MLOs) can be considered as the phenomenon of collective behavior. The conformational dynamics of IDPs are essential for their interactions and the formation of a condensed phase. From a phy... |
39806297 | Ion homeostasis and coordinated salt tolerance mechanisms in a barley (Hordeum vulgare L.)doubled haploid line. | Salinization poses a significant challenge in agriculture. Identifying salt-tolerant plant germplasm resources and understanding their mechanisms of salt tolerance are crucial for breeding new salt-tolerant plant varieties. However, one of the primary obstacles to achieving this goal in crops is the physiological compl... |
39805989 | Highly electroactive thiazolium [5,4-d]thiazol-2,5-dicarboxylic acid-silver electrochemiluminescent metal-organic frameworks: synthesis, properties and application in glutathione detection. | Thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid (H<sub>2</sub>Thz), a thiazolothiazole (TTz) derivative with carboxylic acid groups, was synthesized as a ligand for the creation of five MOFs, each associated with distinct metal ions including Ag<sup>+</sup>, Mn<sup>2+</sup>, Co<sup>2+</sup>, Zn<sup>2+</sup>, and Cu<sup>2... |
39805836 | Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy. | Tongue squamous cell carcinoma (TSCC) is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion. Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients. The current treatment modalit... |
39801269 | Immunoinformatics-guided design of a multiepitope peptide vaccine targeting the receptor-binding domain of SARS-CoV-2 spike glycoprotein: insights from Indonesian samples. | The emergence of new variants of SARS-CoV-2, including Alpha, Beta, Gamma, Delta, Omicron variants, and XBB sub-variants, contributes to the number of coronavirus cases worldwide. SARS-CoV-2 is a positive RNA virus with a genome of 29.9 kb that encodes four structural proteins: spike glycoprotein (S), envelope glycopro... |
39777807 | DNA Origami Adsorption and Lattice Formation on Different SiO<sub>x</sub> Surfaces. | Self-assembled DNA origami lattices on silicon oxide surfaces have great potential to serve as masks in molecular lithography. However, silicon oxide surfaces come in many different forms and the type and history of the silicon oxide has a large effect on its physicochemical surface properties. Therefore, we here inves... |
39776029 | Packing Engineering of Zirconium Metal-Organic Cages in Mixed Matrix Membranes for CO<sub>2</sub>/CH<sub>4</sub> Separation. | Metal-organic cages (MOCs) have been considered as emerging zero-dimensional (0D) porous fillers to generate molecularly homogeneous MOC-based membrane materials. However, the discontinuous pore connectivity and low filler concentrations limit the improvement of membrane separation performance. Herein, we propose the d... |
39743678 | 2,3 : 6,7-Naphthalenediimide-Based Chiral Triangular Macrocycle: Self-Assembled Helix, Outer π-Surface Directed Co-Assembly and Circularly Polarized Luminescence. | Here, we report the synthesis and self-assembly of a novel chiral 2,3 : 6,7-naphthalenediimide-based triangular macrocycle (NDI-Δ) and its chiroptical properties. The enantiomeric NDI-Δ is synthesized by condensation of (RR) or (SS)-trans-1,2-cyclohexanediamine and 2,3,6,7-naphthalenetetracarboxylic 2,3 : 6,7-dianhydri... |
39715287 | Light-Driven Adaptive Molecular Crystals Activated by [2+2] and [4+4] Cycloadditions. | Photomechanical crystals act as light-driven material-machines that can convert the energy carried by photons into kinetic energy via shape deformation or displacement, and this capability holds a paramount significance for the development of photoactuated devices. This transformation is usually attributed to anisotrop... |
39692802 | Chemoselective homologative preparation of trisubstituted alkenyl halides from carbonyls and carbenoids. | The chemoselective synthesis of trisubstituted alkenyl halides (Cl, Br, F, I) starting from ketones and aldehydes and lithium halocarbenoids is reported. Upon forming the corresponding tetrahedral intermediate adduct, followed by the addition of thionyl chloride, a selective E2-type elimination is triggered, furnishing... |
39668774 | Advances in chemistry of CALF-20, a metal-organic framework for industrial gas applications. | The metal-organic framework CALF-20 is a super-stable adsorbent utilised for carbon dioxide capture and storage in cement plants. Furthermore, recent findings suggest its potential for various gas-related applications. In this brief review, we summarise ten years of research on CALF-20, emphasising its historical backg... |
39620696 | Zwitterionic polymers with high serum tolerance for intracellular protein delivery. | Cationic polymers have been widely developed as carriers for intracellular protein delivery, but face tough challenges such as poor serum tolerance and inevitable material toxicity. Here, we present a type of phase-separating polymer with an anionic surface to address the above issues. A cationic dendrimer is first mod... |
39319382 | Sequence determinants of protein phase separation and recognition by protein phase-separated condensates through molecular dynamics and active learning. | Elucidating how protein sequence determines the properties of disordered proteins and their phase-separated condensates is a great challenge in computational chemistry, biology, and biophysics. Quantitative molecular dynamics simulations and derived free energy values can in principle capture how a sequence encodes the... |
39308396 | Modelling ligand exchange in metal complexes with machine learning potentials. | Metal ions are irreplaceable in many areas of chemistry, including (bio)catalysis, self-assembly and charge transfer processes. Yet, modelling their structural and dynamic properties in diverse chemical environments remains challenging for both force fields and <i>ab initio</i> methods. Here, we introduce a strategy to... |
40095657 | Biomaterial-based strategies: a new era in spinal cord injury treatment. | Enhancing neurological recovery and improving the prognosis of spinal cord injury have gained research attention recently. Spinal cord injury is associated with a complex molecular and cellular microenvironment. This complexity has prompted researchers to elucidate the underlying pathophysiological mechanisms and chang... |
40015766 | Saliva analysis using metal-organic framework-coated miniaturized vials. | <h4>Background</h4>In-vial microextraction is probably the simplest microextraction technique because it eliminates centrifugation and/or filtration steps while offering short extraction and desorption times. However, it has had limited applicability, mostly involving polydimethylsiloxane coatings and gas chromatograph... |
39967184 | Photocatalytic degradation of the pesticide pyridaben: Identification of degradation pathways using SERS and GC-MS. | Degradation pathways of the pesticide pyridaben in tea caused by ultraviolet photocatalytic degradation were identified using SERS and GC-MS. Pyridaben in tea decreased from 4.50 mg/kg to 3.46 mg/kg after 2 h and to 0.62 mg/kg after 5 h, with a degradation rate of 86.22 % and a recovery rate of 90.00 %. The pyridaben d... |
39967067 | Simultaneous adsorption and fluorescent sensing of ampicillin based on a trimetallic metal-organic framework. | Antibiotic residue is a growing concern for human health, and exploring a method for antibiotic detection is imperative Herein, a trimetallic metal-organic framework (NH2-MIL-53(Al)@Mo/Zn-MOF) with an adsorption effect was prepared by growing Mo/Zn-MOF on the surface of NH<sub>2</sub>-MIL-53(Al) for simultaneous pre-co... |
39944761 | Evolutionary Specialization of a Promiscuous Designer Enzyme. | The evolution of a promiscuous enzyme for its various activities often results in catalytically specialized variants. This is an important natural mechanism to ensure the proper functioning of natural metabolic networks. It also acts as both a curse and blessing for enzyme engineers, where enzymes that have undergone d... |
39927227 | Discovery of novel vaccine candidates based on the immunogenic epitopes derived from <i>Toxoplasma</i> membrane proteins. | <h4>Purpose</h4>Due to the widespread distribution and importance of <i>Toxoplasma gondii</i> infection as a parasitic zoonosis, multi-epitope vaccine design was implemented using a set of immunodominant epitopes screened out of a wide scope of membrane proteins.<h4>Materials and methods</h4>On this basis, 5 vaccine ca... |
39917021 | PET imaging of HIV-1 envelope protein gp120 using <sup>18</sup>F-labeled nanobodies. | Radiolabeled antibodies against the HIV-1 envelope protein, gp120, have been previously tested in animal models and in people with HIV (PWH). Nanobodies offer advantages over antibodies, including smaller size and faster clearance, which allow labeling with fluorine-18. In this study, three nanobodies (J3, 3E3, B9) cho... |
39911431 | Human immune system: Exploring diversity across individuals and populations. | The immune response is an intricate system that involves the complex connection of cellular and molecular components, each with distinct functional specialisations. It has a distinct capacity to adjust and mould the immune response in accordance with specific stimuli, influenced by both genetic and environmental factor... |
39906206 | Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation. | Severe acute pancreatitis (SAP), a life-threatening inflammatory disease of the pancreas, has a high mortality rate (∼40 %). Current therapeutic approaches, including antibiotics, trypsin inhibitors, fasting, rehydration, and even continuous renal replacement therapy, yield limited clinical management efficacy. Abnorma... |
39897966 | Exploring the potentials of indigenous <i>Saccharomyces cerevisiae</i> and <i>Pichia kudriavzevii</i> for enhancing flavour and aromatic characteristics in apricot wines. | In this study, we investigated the oenological performance of key yeast populations previously identified from apricot wine fermentation, aiming to obtain indigenous starters suitable for apricot wine production. Twenty-one isolates were characterized physiologically, and two isolates each of <i>Saccharomyces cerevisia... |
39897972 | Food packaging films from natural polysaccharides and protein hydrogels: A comprehensive review. | The development of innovative, biodegradable food packaging materials to combat plastic pollution has garnered significant attention from scholars and government agencies worldwide. Natural polysaccharides and proteins exhibit excellent modifiability, biodegradability, high ductility, and compatibility with food produc... |
39897052 | An Exploration of the Universal and Switchable RAFT-Mediated Synthesis of Poly(styrene-<i>alt</i>-maleic acid)-<i>b</i>-poly(<i>N</i>-vinylpyrrolidone) Block Copolymers. | The synthesis of poly(styrene-<i>alt</i>-maleic anhydride) (SMAnh) and poly(4-<i>tert</i>-butylstyrene-<i>alt</i>-maleic anhydride) (<i>t</i>BuSMAnh) macro-RAFT agents was investigated using universal 3,5-dimethylpyrazole dithiocarbamate and stimuli-responsive <i>N</i>-(4-pyridinyl)-<i>N</i>-methyldithiocarbamate RAFT ... |
39896991 | Progress in enzyme-powered micro/nanomotors in diagnostics and therapeutics. | Enzyme-powered micro/nanomotors (EMNMs) represent cutting-edge research taking advantage of enzymes as biocatalysts to provide a driving force for micro/nanomotors. Up to now, EMNMs have been designed to be powered by catalase, urease, lipase, collagenase, compound enzymes, <i>etc</i>. They not only have good biocompat... |
39896279 | Redox-responsive metal-organic framework nanocapsules enhance tumor chemo-immunotherapy by modulating tumor metabolic reprogramming. | Immunotherapy, particularly immune checkpoint blockade (ICB), has opened the era of modern oncology, offering significant promise for modern oncology. However, the efficacy of immunotherapy is frequently curtailed by the immunosuppressive tumor microenvironment (ITM), a milieu shaped by tumor metabolic reprogramming. H... |
39895749 | Wide Bandwidth High-Power Triboelectric Energy Harvesting by Scotch Tape. | A triboelectric generator was proposed using commercial tape materials, which are composed of metalized poly(ethylene terephthalate) films to serve as electrodes and Scotch tape layers for power generation. Power extraction is achieved by the interaction between polypropylene and the acrylic adhesive layer when pressin... |
39895738 | Formulation and Evaluation of a Silymarin Inclusion Complex-Based Gel for Skin Cancer. | Silymarin (SLM) is a bioactive, water-insoluble flavonoid reported against different types of cancer. In the present research, the SLM inclusion complex was prepared by the freeze-drying method using different cyclodextrins. The phase solubility study was performed to assess the stability constant and complexation effi... |
39895723 | Python-Based Algorithm for Estimating NRTL Model Parameters with UNIFAC Model Simulation Results. | A major challenge in bioprocess simulation is the lack of physical and chemical property databases for biochemicals. A Python-based algorithm was developed for estimating the nonrandom two-liquid (NRTL) model parameters of aqueous binary systems in a straightforward manner from simplified molecular-input line-entry spe... |
39895721 | Uncovering the Binding Mechanism of Mutated Omicron Variants via Computational Strategies. | The COVID-19 pandemic, triggered by the SARS-CoV-2 virus, has resulted in nearly 630 million cases and 6.60 million fatalities globally, as of November 2022. SARS-CoV-2, a species of the Coronaviridae family, has a single-stranded positive-sense RNA genome as well as four main structural proteins (S, E, M, and N) requi... |
39872522 | DNA vaccines as promising immuno-therapeutics against cancer: a new insight. | Cancer is one of the leading causes of mortality around the world and most of our conventional treatments are not efficient enough to combat this deadly disease. Harnessing the power of the immune system to target cancer cells is one of the most appealing methods for cancer therapy. Nucleotide-based cancer vaccines, es... |
39872521 | Proteomics and transcriptomics combined reveal specific immunological markers in autoimmune thyroid disease. | <h4>Objective</h4>The pathogenesis of AITD remains unclear to date. This study employs a combination of proteomics and transcriptomics analysis to identify and validate specific immune response markers in patients with hyperthyroidism and hypothyroidism, thereby providing a scientific basis for the clinical diagnosis a... |
39863313 | Ratiometric fluorescent aptasensor based on DNA-gated Fe<sub>3</sub>O<sub>4</sub>@Uio-66-NH<sub>2</sub> and Exo I-assisted signal amplification. | <h4>Background</h4>Ochratoxin A (OTA) is toxic secondary metabolites produced by fungi and can pose a serious threat to food safety and human health. Due to the high stability and toxicity, OTA contamination in agricultural products is of great concern. Therefore, the development of a highly sensitive and reliable OTA ... |
39861886 | Role of the Psi Packaging Signal and Dimerization Initiation Sequence in the Organization of Rous Sarcoma Virus Gag-gRNA Co-Condensates. | Retroviral genome selection and virion assembly remain promising targets for novel therapeutic intervention. Recent studies have demonstrated that the Gag proteins of Rous sarcoma virus (RSV) and human immunodeficiency virus type-1 (HIV-1) undergo nuclear trafficking, colocalize with nascent genomic viral RNA (gRNA) at... |
39861560 | The Physicochemical and Rheological Properties of Green Banana Flour-Wheat Flour Bread Substitutions. | Functional foods are currently receiving increasing popularity in diet modification. Green bananas contain far more dietary fiber (DF) and resistant starch (RS) than mature bananas. The potential for integrating these vital components into food, such as bread, has expanded. Thus, this study aimed to examine the physico... |
39861150 | Non-Viral Delivery Systems to Transport Nucleic Acids for Inherited Retinal Disorders. | Inherited retinal disorders (IRDs) represent a group of challenging genetic conditions that often lead to severe visual impairment or blindness. The complexity of these disorders, arising from their diverse genetic causes and the unique structural and functional aspects of retinal cells, has made developing effective t... |
39861149 | Development of a Hydrocortisone Orodispersible Thin Film Containing Its Succinate Prodrug. | Orodispersible thin film (ODF) is an innovative dosage form that allows for adjustable dosing and improved patient compliance. It is administered by mouth, where it dissolves, making it suitable for children.<h4>Objectives</h4>The aim of the study was to develop and characterize an optimal ODF formulation containing eq... |
39861155 | Anti-Biofilm Agents to Overcome <i>Pseudomonas aeruginosa</i> Antibiotic Resistance. | <i>Pseudomonas aeruginosa</i> is one of world's most threatening bacteria. In addition to the emerging prevalence of multi-drug resistant (MDR) strains, the bacterium also possesses a wide variety of virulence traits that worsen the course of the infections. Particularly, its ability to form biofilms that protect colon... |
39860163 | Native Cyclodextrin-Based Metal-Organic Frameworks (MOFs): Synthesis, Characterization, and Potential Applications in Food Industry. | Metal-organic frameworks (MOFs) have become a highly usable system in various sectors because of their highly ordered structure and high porosity providing them with high storage capacity. However, their use is sometimes forbidden in the food industry due to the presence of some organic compounds which have undesirable... |
39860151 | Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile Acid Levels. | Our previous study demonstrated that γ-cyclodextrin (γ-CD)-perilla oil inclusion complexes increase plasma α-linolenic acid and eicosapentaenoic acid levels in healthy rats without adverse effects. The present study examined the effects of perilla oil, γ-CD, and their inclusion complexes on rats fed cholic acid (CA) to... |
39859347 | Predicting the Anti-SARS-CoV-2 Potential of Isoquinoline Alkaloids from Brazilian Siparunaceae Species Using Chemometric Tools. | The COVID-19 pandemic has caused over 7 million deaths globally in the past four years. <i>Siparuna</i> spp. (Siparunaceae), which is used in Brazilian folk medicine, is considered a genus with potential antiviral alternatives. This study explored the correlation between phytochemicals in <i>Siparuna</i> leaf extracts ... |
39859345 | Molecular Mechanisms of Dietary Compounds in Cancer Stem Cells from Solid Tumors: Insights into Colorectal, Breast, and Prostate Cancer. | Cancer stem cells (CSC) are known to be the main source of tumor relapse, metastasis, or multidrug resistance and the mechanisms to counteract or eradicate them and their activity remain elusive. There are different hypotheses that claim that the origin of CSC might be in regular stem cells (SC) and, due to accumulatio... |
39859320 | Potential Use of Selected Natural Compounds with Anti-Biofilm Activity. | Antibiotic resistance in microorganisms is an escalating global concern, exacerbated by their formation of biofilms, which provide protection through an extracellular matrix and communication via quorum sensing, enhancing their resistance to treatment. This situation has driven the search for alternative approaches, pa... |
39852770 | The Rise of Pluripotent Stem Cell-Derived Glia Models of Neuroinflammation. | Neuroinflammation is a blanket term that describes the body's complex inflammatory response in the central nervous system (CNS). It encompasses a phenotype shift to a proinflammatory state, the release of cytokines, the recruitment of peripheral immune cells, and a wide variety of other processes. Neuroinflammation has... |
39852267 | Simultaneously Enhanced Permeability and Selectivity of Pebax-1074-Based Mixed-Matrix Membrane for CO<sub>2</sub> Separation. | Membrane technology is a promising methodology for carbon dioxide separation due to its benefit of a small carbon footprint. However, the trade-off relationship between gas permeability and selectivity is one obstacle to limiting its application. Herein, branched polyethyleneimine (BPEI) containing a rich amino group w... |
39852264 | Realization of Intermolecular Interactions as a Basis for Controlling Pervaporation Properties of Membranes Made of Aromatic Polyamide-Imides. | New aromatic co-polyamide-imides (coPAIs) containing both carboxyl and hydroxyl groups in the repeating units were synthesized for the first time. Transport, thermal and morphological properties of dense nonporous membranes from PAIs obtained using the diacid chloride of 2-(4-carboxyphenyl)-1,3-dioxoisoindoline-5-carbo... |
39852097 | Mapping Surface Potential in DNA Aptamer-Neurochemical and Membrane-Ion Interactions on the SOS Substrate Using Terahertz Microscopy. | In this study, we utilized a terahertz chemical microscope (TCM) to map surface potential changes induced by molecular interactions on silicon-on-sapphire (SOS) substrates. By functionalizing the SOS substrate with DNA aptamers and an ion-selective membrane, we successfully detected and visualized aptamer-neurochemical... |
39852095 | Exploring Innovative Approaches for the Analysis of Micro- and Nanoplastics: Breakthroughs in (Bio)Sensing Techniques. | Plastic pollution, particularly from microplastics (MPs) and nanoplastics (NPs), has become a critical environmental and health concern due to their widespread distribution, persistence, and potential toxicity. MPs and NPs originate from primary sources, such as cosmetic microspheres or synthetic fibers, and secondary ... |
39852093 | Anti-Tissue-Transglutaminase IgA Antibodies Presence Determination Using Electrochemical Square Wave Voltammetry and Modified Electrodes Based on Polypyrrole and Quantum Dots. | A novel electrochemical detection method utilizing a cost-effective hybrid-modified electrode has been established. A glassy carbon (GC) modified electrode was tested for its ability to measure electrochemical tTG antibody levels, which are essential for diagnosing and monitoring Celiac disease (CD). Tissue transglutam... |
39852092 | Pioneering Role of Nanopore Single-Molecule Sensing in Environmental and Food Surveillance. | In recent years, environmental and food safety have garnered substantial focus due to their intimate connection with human health. Numerous biosensors have been developed for identifying deleterious compounds; however, these biosensors reveal certain limitations. Nanopore sensors, featuring nano-scaled pore size, have ... |
39852034 | Self-Assembled Peptide Hydrogels PPI45 and PPI47: Novel Drug Candidates for <i>Staphylococcus aureus</i> Infection Treatment. | <i>Staphylococcus aureus</i>, a prevalent zoonotic pathogen, poses a significant threat to skin wound infections. This study evaluates the bactericidal efficacy of self-assembled peptide hydrogels, PPI45 and PPI47, derived from the defensin-derived peptide PPI42, against <i>S. aureus</i> ATCC43300. The high-level prepa... |
39845135 | A biocompatible β-cyclodextrin inclusion complex containing natural extracts: a promising antibiofilm agent. | Biofilms formed by several bacterial strains still pose a significant challenge to healthcare due to their resistance to conventional treatment approaches, including antibiotics. This study explores the potential of loading natural extracts with antimicrobial activities into β-cyclodextrin (βCD) nanoparticles, which ar... |
39840291 | Competing pathways to aromaticity governed by amine dehydrogenation and metal-organic complexation in on-surface synthesis. | We investigated the reactivity of a <i>gem</i>-dichlorovinyl-carbazole precursor in the on-surface synthesis approach. Our findings reveal that, on the Au(111) surface, the thermally-induced dehalogenation reaction led to the formation of cumulene dimers. Contrastingly, the more reactive Cu(111) surface promoted the fo... |
39839215 | Advancements and challenges of onboard carbon capture and storage technologies for the maritime industry: a comprehensive review. | In response to the growing demand of reducing greenhouse gas (GHG) emissions within maritime sector, Onboard Carbon Capture and Storage (OCCS) technologies provide as key solutions for tackling carbon dioxide (CO<sub>2</sub>) emissions from ships. This review paper offers a comprehensive overview of recent developments... |
39837247 | Boosting peroxymonosulfate activation for complete removal of gatifloxacin by a bead-chain zeolitic imidazolate framework composite. | A bead-chain metal-organic framework composite was designed and synthesized by assembling a zeolitic imidazolate framework (ZIF) onto manganese dioxide (MnO<sub>2</sub>) nanowires. The prepared catalyst MnO<sub>2</sub>@ZIF-X (X = 1, 2 and 3) was used to facilitate gatifloxacin (GAT) degradation by using potassium perox... |
39837178 | MOF@Ag/AAB/Au@Ag composite matrix full-dimensional divergence effect-based SERS paper sensor for rapid carbaryl quantification. | Carbaryl is a broad-spectrum carbamate fungicide that may pose a threat to ecosystems and human health. To prevent and control the harm caused by excessive application of carbaryl, a full-dimensional divergence effect SERS sensor has been constructed. Biodegradable paper chips were used as sensor substrates. ZIF-8 with... |
39827547 | A review of the latest advancements in using β-cyclodextrin-based as supramolecular catalysts for Heck reactions. | The Heck reaction is one of the most well-known C-C (carbon-carbon) coupling reactions and was identified with the Nobel Prize in Chemistry in 2010. These reactions have been broadly utilized to prepare a different spectrum of heterocycles with applications in agrochemical and pharmaceutical industries. These reactions... |
39826524 | Immobilization of a novel bacteriophage PpZDSS02 onto the peroxidase-mimicking Cu-MOF for colorimetric sensing of Proteus penneri encompassing both promotion and inhibition mechanisms. | A chromogenic system utilizing a novel bacteriophage-integrated nanozyme was established for Proteus penneri detection. Initially, a novel bacteriophage PpZDSS02 was isolated and identified, demonstrating exceptional biological properties and harboring genes that exhibit specific recognition ability. Afterwards, a PpZD... |
39824076 | Inclusion of α-Linolenic acid ethyl ester in flaxseed oil with β-Cyclodextrin by hydrogen bonding. | β-Cyclodextrin (β-CD) enhances functional properties by forming inclusion complexes (ICs). This study employed β-CD to form IC with fatty acid ethyl ester (FAEE) for concentrating α-Linolenic acid ethyl ester (ALAEE) from flaxseed oil FAEE, and investigated the interaction mechanisms between β-CD and ALAEE. Using the s... |
39816617 | Revisiting the potential of natural antimicrobial peptides against emerging respiratory viral disease: a review. | This review assesses the antiviral capabilities of antimicrobial peptides (AMPs) against SARS-CoV-2 and other respiratory viruses, focussing on their therapeutic potential. AMPs, derived from natural sources, exhibit promising antiviral properties by disrupting viral membranes, inhibiting viral entry, and modulating ho... |
39816166 | Characterization and enhanced antibiofilm activity of <i>Annona muricata</i> extract in combination with fluconazole against <i>Candida albicans</i>. | <h4>Introduction</h4><i>Candida albicans</i> biofilm formation is a significant contributor to antifungal resistance, necessitating new treatment strategies. <i>Annona muricata</i> Lin., a traditional herbal remedy, has shown promise in combating microbial infections. The purpose of this study was to assess the antibio... |
39814307 | Design and theoretical calculation of chitosan derivatives: Amphiphilic chitosan micelles loaded with Chinese fir essential oil. | The unique structure of chitosan-based micelles can be loaded with essential oil, so it is significant to study the modification of chitosan and the interactions between chitosan and essential oil, while molecular dynamics (MD) simulation and density functional theory (DFT) provide a solution. In this study, three kind... |
39814294 | Development of a StIW111C-based bioresponsive pore-forming conjugate for permeabilizing the endosomal membrane. | Gene expression manipulation is pivotal in therapeutic approaches for various diseases. Non-viral delivery systems present a safer alternative to viral vectors, with reduced immunogenicity and toxicity. However, their effectiveness in promoting endosomal escape, a crucial step in gene transfer, remains limited. To addr... |
39814293 | Polydopamine-assisted ion-mediated hyaluronic acid grafting for effective construction of hemocompatible platform with cancer cell recognition. | Surfaces capable of specific biomolecule recognition are essential for cancer theranostics, biosensing, and tissue engineering. However, current grafting methods, critical for dictating the recognition efficiency and biocompatibility of biomaterials, especially hydrophilic polymers, struggle to balance high grafting de... |
39814227 | Recent advances in the synthesis and application of biomolecular condensates. | Biomolecular condensates (BMCs) represent a group of organized and programmed systems that participate in gene transcription, chromosome organization, cell division, tumorigenesis, and aging. However, the understanding of BMCs in terms of internal organizations and external regulations remains at an early stage. Recent... |
39811015 | Levator aponeurosis advancement with partial orbicularis oculi muscle resection for the treatment of Marin Amat syndrome with aponeurotic ptosis: two Case reports. | Marin Amat syndrome is a phenomenon in which eyelids close upon opening of the mouth during the recovery phase after facial nerve paralysis. In this report, we present two surgically treated cases of Marin Amat syndrome with aponeurotic ptosis. Case 1: A 66-year-old man had developed left Bell's palsy a year prior to p... |
39809275 | Toward curing neurological autoimmune disorders: Biomarkers, immunological mechanisms, and therapeutic targets. | Autoimmune neurology is a rapidly expanding field driven by the discovery of neuroglial autoantibodies and encompassing a myriad of conditions affecting every level of the nervous system. Traditionally, autoantibodies targeting intracellular antigens are considered markers of T cell-mediated cytotoxicity, while those t... |
39809265 | Enabling tumor-specific drug delivery by targeting the Warburg effect of cancer. | Metabolic reprogramming of tumor cells is an emerging hallmark of cancer. Among all the changes in cancer metabolism, increased glucose uptake and the accumulation of lactate under normoxic conditions (the "Warburg effect") is a common feature of cancer cells. In this study, we develop a lactate-responsive drug deliver... |
39808946 | ATAD2 is a potential immunotherapy target for patients with small cell lung cancer harboring HLA-A∗0201. | <h4>Background</h4>Small cell lung cancer (SCLC) represents a highly aggressive neuroendocrine tumour with a dismal prognosis. Currently, the identification of a specific tumour antigen that can facilitate immune-based therapies for SCLC remains elusive.<h4>Methods</h4>We employed liquid chromatography-tandem mass spec... |
39808525 | mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase. | One critical aspect of cell proliferation is increased nucleotide synthesis, including pyrimidines. Pyrimidines are synthesized through de novo and salvage pathways. Prior studies established that the mammalian target of rapamycin complex 1 (mTORC1) promotes pyrimidine synthesis by activating the de novo pathway for ce... |
39801464 | Evolution of the RNA alternative decay <i>cis</i> element into a high-affinity target for the immunomodulatory protein Roquin. | RNA <i>cis</i> elements play pivotal roles in regulatory processes, e.g. in transcriptional and translational regulation. Two stem-looped <i>cis</i> elements, the constitutive and alternative decay elements (CDE and ADE, respectively) are shape-specifically recognized in mRNA 3' untranslated regions (UTRs) by the immun... |
39807308 | Human Hair Follicle Mesenchymal Stem Cell-Derived Exosomes Attenuate UVB-Induced Photoaging via the miR-125b-5p/TGF-β1/Smad Axis. | Cutaneous photoaging, induced by chronic exposure to ultraviolet (UV) radiation, typically manifests as alterations in both the physical appearance and functional properties of the skin and may predispose individuals to cancer development. Recent studies have demonstrated the reparative potential of exosomes derived fr... |
39807203 | Application of novel silica stabilized on a covalent triazine framework as a highly efficient heterogeneous and recyclable catalyst in the effective green synthesis of porphyrins. | In this study, we present the design, synthesis, and utilization of a covalent triazine framework (CTF) formed by the condensation of <i>N</i> <sup>2</sup>,<i>N</i> <sup>4</sup>,<i>N</i> <sup>6</sup>-tris(4-(aminomethyl)benzyl)-1,3,5-triazine-2,4,6-triamine and 2,4,6-tris(4-formylphenoxy)-1,3,5-triazine on which silica... |
39807186 | Intramolecular noncovalent C-bonding driven conformational preference in spiroisatin-based <i>N</i>-acyl hydrazones. | Noncovalent carbon bonding (C-bonding), a recently explored σ-hole interaction, has primarily been characterized through X-ray structural and computational studies. Evidence of C-bonds in solution is scarce, especially in highly polar solvents like DMSO where solvation effects typically overshadow weak non-covalent int... |
39806939 | Organelle-Targeting Nanoparticles. | Organelles are specialized subunits within cells which carry out vital functions crucial to cellular survival and form a tightly regulated network. Dysfunctions in any of these organelles are linked to numerous diseases impacting virtually every organ system in the human body. Targeted delivery of therapeutics to speci... |
39806938 | Advanced Solid Lubrication with COK-47: Mechanistic Insights on the Role of Water and Performance Evaluation. | Metal-organic framework (MOF) nanoparticles have attracted widespread attention as lubrication additives due to their tunable structures and surface effects. However, their solid lubrication properties have been rarely explored. This work introduces the positive role of moisture in solid lubrication in the case of a ne... |
39806935 | Enhancing the Implant Osteointegration via Supramolecular Co-Assembly Coating with Early Immunomodulation and Cell Colonization. | Osteointegration, the effective coupling between an implant and bone tissue, is a highly intricate biological process. The initial stages of bone-related immunomodulation and cellular colonization play crucial roles, but have received limited attention. Herein, a novel supramolecular co-assembled coating of strontium (... |
39806816 | Twisted Cucurbit[14]uril-Based Supramolecular Self-Assembly Induces Fluorescence Emission of Dye Molecules for Multi-Channel Cell Imaging. | In this study, a supramolecular fluorescent material was constructed by using double-cavity twisted cucurbit[14]uril (tQ[14]) and positively charged Astrazon Pink FG (APFG) based on the non-covalent host-guest interaction for the first time. The thermodynamic parameters of the APFG@tQ[14] in aqueous solution were deter... |
39806451 | Emerging role of exosomes in cancer therapy: progress and challenges. | This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple cancer types. As small extracellular vesicles, exosomes exhibit high biocompatibility and low immunogenicity, making them ideal drug de... |
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