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39806308 | Methanol-Enhanced Low-Cell-Voltage Hydrogen Generation at Industrial-Grade Current Density by Triadic Active Sites of Pt<sub>1</sub>-Pd<i><sub>n</sub></i>-(Ni,Co)(OH)<sub><i>x</i></sub>. | Methanol (ME) is a liquid hydrogen carrier, ideal for on-site-on-demand H<sub>2</sub> generation, avoiding its costly and risky distribution issues, but this "ME-to-H<sub>2</sub>" electric conversion suffers from high voltage (energy consumption) and competitive oxygen evolution reaction. Herein, we demonstrate that a ... |
39806279 | Preclinical and First-in-Human Study of a Compact Radionuclide Labeled Self-Assembly Nanomedicine for Chemo-Radio-Theranostics of Cancer. | The emerging combination of chemotherapy and radionuclide therapy has been actively investigated to overcome the limitations of monotherapy and augment therapeutic efficacy. However, it remains a challenge to design a single delivery vehicle that can incorporate chemotherapeutics and radionuclides into a compact struct... |
39806067 | Transforming an ATP-dependent enzyme into a dissipative, self-assembling system. | Nucleoside triphosphate (NTP)-dependent protein assemblies such as microtubules and actin filaments have inspired the development of diverse chemically fueled molecular machines and active materials but their functional sophistication has yet to be matched by design. Given this challenge, we asked whether it is possibl... |
39805977 | Hybrid stochastic and robust optimization of a hybrid system with fuel cell for building electrification using an improved arithmetic optimization algorithm. | This paper proposes a hybrid stochastic-robust optimization framework for sizing a photovoltaic/tidal/fuel cell (PV/TDL/FC) system to meet an annual educational building demand based on hydrogen storage via unscented transformation (UT), and information gap decision theory-based risk-averse strategy (IGDT-RA). The hybr... |
39805958 | Morphology remodelling and membrane channel formation in synthetic cells via reconfigurable DNA nanorafts. | The shape of biological matter is central to cell function at different length scales and determines how cellular components recognize, interact and respond to one another. However, their shapes are often transient and hard to reprogramme. Here we construct a synthetic cell model composed of signal-responsive DNA nanor... |
39805917 | Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma. | Osteosarcoma (OS) is the most common primary bone malignancy. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has been implicated in bone destruction, tumor survival and metastases during OS. We examined the role of Dkk-1 in OS disease progression and explored strategies for targeting its activity. Dkk-1 enhances OS sur... |
39805872 | Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity. | Immune functions decline with aging, leading to increased susceptibility to various diseases including tumors. Exploring aging-related molecular targets in elderly patients with cancer is thus highly sought after. Here we find that an ER transmembrane enzyme, sterol O-acyltransferase 2 (SOAT2), is overexpressed in regu... |
39805840 | Targeted co-delivery nanosystem based on methotrexate, curcumin, and PAMAM dendrimer for improvement of the therapeutic efficacy in cervical cancer. | The simultaneous administration of multiple drugs within identical nanocarriers to cancer cells or tissues can result in the effective action of drugs at reduced concentrations. In this investigation, PAMAM dendrimers (G4-PAMAM) were employed to link with methotrexate (MTX) using DCC/NHS chemistry and followed by the e... |
39805842 | Efficient continuous SF<sub>6</sub>/N<sub>2</sub> separation using low-cost and robust metal-organic frameworks composites. | Physisorption presents a promising alternative to cryogenic distillation for capturing the most potent greenhouse gas, SF<sub>6</sub>, but existing adsorbents face challenges in meeting diverse chemical and engineering concerns. Herein, with insights into in-pore chemistry and industrial process design, we report a sys... |
39805770 | Staudinger Reaction-Responsive Coacervates for Cytosolic Antibody Delivery and TRIM21-Mediated Protein Degradation. | A low-molecular-weight compound whose structure strikes a fine balance between hydrophobicity and hydrophilicity may form coacervates via liquid-liquid phase separation in an aqueous solution. These coacervates may encapsulate and convoy proteins across the plasma membrane into the cell. However, releasing the cargo fr... |
39805740 | Trapping Anions within Stacks of Tetra-Urea Macrocycles. | Designing molecular receptors that bind anions in water is a significant challenge, and an even greater difficulty lies in using these receptors to remove anions from water without resorting to the hazardous liquid-liquid extraction approach. We here demonstrate an effective and synthetically simple strategy toward the... |
39805660 | CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors. | <h4>Background</h4>Adaptive cellular therapy (ACT), particularly chimeric antigen receptor (CAR)-T cell therapy, has been successful in the treatment of hemopoietic malignancies. However, poor trafficking of administered effector T cells to the tumor poses a great hurdle for this otherwise powerful therapeutic approach... |
39805091 | Synthetic Lipid Biology. | Cells contain thousands of different lipids. Their rapid and redundant metabolism, dynamic movement, and many interactions with other biomolecules have justly earned lipids a reputation as a vexing class of molecules to understand. Further, as the cell's hydrophobic metabolites, lipids assemble into supramolecular stru... |
39805045 | Hypoxia-Initiated Supramolecular Free Radicals Induce Intracellular Polymerization for Precision Tumor Therapy. | Despite the development of various controlled release systems for antitumor therapies, off-target side effects remain a persistent challenge. In situ therapeutic synthesis from biocompatible substances offers a safer and more precise alternative. This study presents a hypoxia-initiated supramolecular free radical syste... |
39804998 | Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules. | Template-directed synthesis has become a powerful methodology to access complex molecules. Noncovalent templating has been widely used in the last few decades, but less attention has been paid to covalent template-directed synthesis, despite the fact that this methodology was used for the first reported synthesis of a ... |
39804984 | Spatiotemporal Dynamic Immunomodulation by Infection-Mimicking Gels Enhances Broad and Durable Protective Immunity Against Heterologous Viruses. | Despite their safety and widespread use, conventional protein antigen-based subunit vaccines face significant challenges such as low immunogenicity, insufficient long-term immunity, poor CD8<sup>+</sup> T-cell activation, and poor adaptation to viral variants. To address these issues, an infection-mimicking gel (IM-Gel... |
39804980 | Molecular Determinants of Protein Pathogenicity at the Single-Aggregate Level. | Determining the structure-function relationships of protein aggregates is a fundamental challenge in biology. These aggregates, whether formed in vitro, within cells, or in living organisms, present significant heterogeneity in their molecular features such as size, structure, and composition, making it difficult to de... |
39804974 | Achieving Narrowband and Stable Pure Blue Organic Light-Emitting Diodes by Employing Molecular Vibration Limited Strategies in the Extended π-Conjugated Indolocarbazole Skeleton. | B- and N-heterocyclic fluorophores have reveal promising efficiency in blue organic light-emitting diodes (OLEDs) with small full-width-at-half-maximum (FWHM). However, their structural determinants for spectral broadening and operating stability are still needed to be investigated in further. Herein, a novel multi-N-h... |
39804963 | N-oxide-Functionalized Bipyridines as Strong Electron-Deficient Units to Construct High-Performance n-Type Conjugated Polymers. | Developing low-cost unipolar n-type organic thin-film transistors (OTFTs) is necessary for logic circuits. To achieve this objective, the usage of new electron-deficient building blocks with simple structure and easy synthetic route is desirable. Among all electron-deficient building units, N-oxide-functionalized bipyr... |
39804953 | Benchmarking residue-resolution protein coarse-grained models for simulations of biomolecular condensates. | Intracellular liquid-liquid phase separation (LLPS) of proteins and nucleic acids is a fundamental mechanism by which cells compartmentalize their components and perform essential biological functions. Molecular simulations play a crucial role in providing microscopic insights into the physicochemical processes driving... |
39804950 | Traditional Chinese Medicine Borneol-Based Polymeric Micelles Intracerebral Drug Delivery System for Precisely Pathogenesis-Adaptive Treatment of Ischemic Stroke. | The scarcity of effective neuroprotective agents and the presence of blood-brain barrier (BBB)-mediated extremely inefficient intracerebral drug delivery are predominant obstacles to the treatment of cerebral ischemic stroke (CIS). Herein, ROS-responsive borneol-based amphiphilic polymeric NPs are constructed by using ... |
39804949 | An Albumin-Photosensitizer Supramolecular Assembly with Type I ROS-Induced Multifaceted Tumor Cell Deaths for Photodynamic Immunotherapy. | Photodynamic therapy holds great potentials in cancer treatment, yet its effectiveness in hypoxic solid tumor is limited by the oxygen-dependence and insufficient oxidative potential of conventional type II reactive oxygen species (ROS). Herein, the study reports a supramolecular photosensitizer, BSA@TPE-BT-SCT NPs, th... |
39804896 | Differential insulin response characteristics of graphene oxide-gold nanoparticle composites under varied synthesis conditions. | The structural alterations in the constituent materials of nanocomposites such as graphene nanocomposites typically induce changes in their properties including mechanical, electrical, and optical properties. Therefore, by altering the preparation conditions of nanocomposites and investigating their responsiveness to b... |
39804882 | Ionic Liquid-Functionalized Defective MOFs for Membrane-Based CO<sub>2</sub> Separation: A Dual Optimization Approach for Interface and Transport. | Defective MOFs have been identified as promising candidates for efficient membrane-based separation applications. However, the utilization of defective MOFs in membrane gas separation is still in its infancy due primarily to the inefficient molecular differentiation induced by structural defects. Herein, we report a st... |
39804802 | Employing Triphenylene-Based, Layered, Conductive Metal-Organic Framework Materials as Electrochemical Sensors for Nitric Oxide in Aqueous Media. | This paper describes the first use of conductive metal-organic frameworks as the active material in the electrochemical detection of nitric oxide in aqueous solution. Four hexahydroxytriphenylene (HHTP)-based MOFs linked with first-row transition metal nodes (M = Co, Ni, Cu, Zn) were compared as thin-film working elect... |
39804801 | Perovskite Nanocrystal Self-Assemblies in 3D Hollow Templates. | Highly ordered nanocrystal (NC) assemblies, namely, superlattices (SLs), have been investigated as materials for optical and optoelectronic devices due to their unique properties based on interactions among neighboring NCs. In particular, lead halide perovskite NC SLs have attracted significant attention owing to their... |
39804788 | Microenvironment Remodeling Microgel Repairs Degenerated Intervertebral Disc via Programmed Delivery of MicroRNA-155. | The progression of intervertebral disc degeneration (IVDD) is associated with increased cell apoptosis and reduced extracellular matrix (ECM) production, both of which are driven by ongoing inflammation. Thus, alleviating the acidic inflammatory microenvironment and mitigating the apoptosis of nucleus pulposus cells (N... |
39804246 | A Hexavalent Tellurium-Based Chalcogen Bonding Catalysis Platform: High Catalytic Activity and Controlling of Selectivity. | Herein, we describe a hexavalent tellurium-based chalcogen bonding catalysis platform capable of addressing reactivity and selectivity issues. This research demonstrates that hexavalent tellurium salts can serve as a class of highly active chalcogen bonding catalysts for the first time. The tellurium centers in these h... |
39804237 | Group a <i>Streptococcus</i> remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination. | Group A <i>Streptococcus</i> (GAS) is a major human pathogen that causes several invasive diseases including necrotizing fasciitis. The host coagulation cascade initiates fibrin clots to sequester bacteria to prevent dissemination into deeper tissues. GAS, especially skin-tropic bacterial strains, utilize specific viru... |
39804191 | ERK1/2 gene expression and hypomethylation of Alu and LINE1 elements in patients with type 2 diabetes with and without cataract: Impact of hyperglycemia-induced oxidative stress. | <h4>Aims</h4>This study aimed to delineate the effect of hyperglycemia on the Alu/LINE-1 hypomethylation and in ERK1/2 genes expression in type 2 diabetes with and without cataract.<h4>Methods</h4>This study included 58 diabetic patients without cataracts, 50 diabetic patients with cataracts, and 36 healthy controls. A... |
39804153 | Ligand Reorganization for End-Point Binding Free Energy Calculations: Identifying Preferred Poses of Fentanyls in the μ Opioid Receptor. | We have developed a method that uses energy landscapes of unbound and bound ligands to compute reorganization free energies for end-point binding free-energy calculations. The method is applied to our previous simulations of fentanyl derivatives bound to the μ opioid receptor in different orientations. Whereas the mean... |
39804126 | Extreme Optical Chirality from Plasmonic Nanocrystals on a Mirror. | Metal nanocrystals synthesized in achiral environments usually exhibit no chiroptical effects. However, by placing nominally achiral nanocrystals 1.3 nm above gold films, we find giant chiroptical effects, reaching anisotropy factors as high as <i>g</i> ≈ 0.9 for single nanodecahedra placed on a gold mirror (NDoM). We ... |
39803919 | Toward Grid-Based Models for Molecular Association. | This paper presents a grid-based approach to model molecular association processes as an alternative to sampling-based Markov models. Our method discretizes the six-dimensional space of relative translation and orientation into grid cells. By discretizing the Fokker-Planck operator governing the system dynamics via the... |
39803829 | Probing Biomolecular Interactions with Paramagnetic Nuclear Magnetic Resonance Spectroscopy. | Recent advances in computational methods like AlphaFold have transformed structural biology, enabling accurate modeling of protein complexes and driving applications in drug discovery and protein engineering. However, predicting the structure of systems involving weak, transient, or dynamic interactions, or of complexe... |
39800747 | Improved conversion of carbon dioxide to methane via photohydrogenation using Gd<sub>2</sub>NiMnO<sub>6</sub> with a dendritic fibrous architecture. | The conversion of diluted CO₂ into high-energy fuels is increasingly central to renewable energy research. This study investigates the efficacy of a Gd₂NiMnO₆ dendritic nanofibrous (DNF) photocatalyst in transforming carbon dioxide to methane through photoreduction. Gd₂NiMnO₆ DNF was found to provide active adsorption ... |
39800733 | Deep imaging of LepR<sup>+</sup> stromal cells in optically cleared murine bone hemisections. | Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach for dissecting the three-dimensional (3D) architecture of tissues and deciphering cellular spatial interactions under physiological and pathological conditions. Deciphering the spatial interaction of leptin receptor-expressing (Le... |
39800731 | A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5. | The global spread of Severe Acute Respiratory Syndrome Coronavirus 2. (SARS-CoV-2) and its variant strains, including Alpha, Beta, Gamma, Delta, and now Omicron, pose a significant challenge. With the constant evolution of the virus, Omicron and its subtypes BA.1, BA.2, BA.3, BA.4, and BA.5 have developed the capacity ... |
39757123 | Self-Healing Elastomers and Coatings via Metal Coordination Bonds. | Self-healing materials can recover the materials from physical damage, and extend the life of equipment. Metal coordination bonds are supramolecular interactions with tunable stability and sensitivity to external stimuli, which are crucial for developing self-healing materials. Incorporating metal coordination bonds in... |
39749415 | Lanthanide-Based Metal-Organic Frameworks Offering Hydrogen Bonding Cavities: Luminescent Characteristics and Sensing Applications. | This work presents the synthesis and characterization of three isomorphous lanthanide-based metal-organic frameworks (Ln-MOFs) (Ln<sup>3+</sup>=Eu (1), Tb (2), and Sm (3)) supported by a pyridine-2,6-dicarboxamide-based linker offering appended arylcarboxylate groups. Single crystal X-ray diffraction studies highlight ... |
39744930 | Photocatalytic Dehalogenation of Aryl Halides Mediated by the Flexible Metal-Organic Framework MIL-53(Cr). | The catalytic potential of flexible metal-organic frameworks (MOFs) remains underexplored, particularly in liquid-phase reactions. This study employs MIL-53(Cr), a prototypical "breathing" MOF capable of structural adaptation via pore size modulation, as a photocatalyst for the dehalogenation of aryl halides. Powder X-... |
39743930 | Segregation of Constitutional Isomers of Some Aromatic Amines Exploiting the Changes of Photo-Luminescence Behaviour of Isoreticular Metal-Organic Frameworks. | Three different two dimensional Cd(II)-based metal-organic frameworks (MOFs) have been synthesized by utilizing same N,N'-donor ligand and three different functionalized dicarboxylate linkers namely isophthalate, 5-nitroisophthalate and 5-hydroxyisophthalate for compound 1, 2 and 3 respectively. The compounds that are ... |
39737808 | Deciphering the Role of Crown-ether Receptor Orientation in C-H Oxidation Catalyzed by Supramolecular Nonheme Fe<sup>IV</sup>(O) Complexes. | The outstanding efficiency and selectivity of enzymatic reactions, such as C-H oxidation by nonheme iron oxygenases, stems from a precise control of substrate positioning inside the active site. The resulting proximity between a specific moiety (a certain C-H bond) and the reactant (a Fe<sup>IV</sup>(O) active species)... |
39716967 | De Novo Design of Lipopeptide-Based β-Sheet-Like Self-Assemblies: A Strategy to Develop Fusion Inhibitors as Broad-Spectrum Antivirals. | The recent surge in emerging viral infections warrants the design of broad-spectrum antivirals. We aim to develop a lead molecule that targets a common biochemical feature of many enveloped viruses, membrane fusion. To achieve the broad-spectrum ability, instead of targeting the fusion machinery, we plan to modulate th... |
39714554 | Tunning the Wettability of the PVDF Membrane using the PVA-Stabilized TA-UiO-66-NH<sub>2</sub> MOF Membranes to Separate Layered Oil-Water Mixture and Surfactant-Stabilized Emulsion. | This study introduces a UiO-66-NH<sub>2</sub>/Tannic acid/Polyvinylidene fluoride (UTP) composite membrane for efficient oil-water separation. Pristine polyvinylidene fluoride (PVDF) membranes, due to their hydrophobic nature, tend to foul during oil-in-water emulsion separation. By incorporating the metal-organic fram... |
39620716 | β-Cyclodextrin modified imidazole probe specific recognition of organic acids based on nuclear magnetic resonance. | Supramolecular interactions play an important role in molecular recognition. Cyclodextrins (CDs) are excellent hosts that are frequently utilized in the identification of chemical compounds. Proper modifications to CD can give it the ability to accurately recognize specific molecules. In this research, CD was modified ... |
39607365 | <i>In situ</i> growth of octa-phenyl polyhedral oligomeric silsesquioxane nanocages over fluorinated graphene nanosheets: super-wetting coatings for oil and organic sorption. | Superhydrophobic surfaces offer significant advantages through their hierarchical micro/nanostructures, which create optimal surface roughness and low surface energy, making the development of robust surfaces essential for enhancing their physical and chemical stability. Here, we introduce <i>in situ</i> growth of octa... |
39589280 | Development of a water-soluble ouroboros-like calix[6]arene-trisimidazole-based ligand for enhanced binding of zinc. | Increasing the thermodynamic stability of metal complexes in water is a key challenge for various applications of coordination chemistry. In this study, a calix[6]arene macrocycle functionalized with three imidazole units on the narrow rim and three primary amino legs on the wide rim was synthesized and studied. This l... |
39584597 | Supramolecular bidentate rhodium(I) or iridium(I) phosphine and oxazoline amino acid bioconjugates as selective catalysts for enantioselective reactions. | This publication describes monodentate phosphine and oxazoline ligands attached to an amino acid ester and the application of their supramolecularly assembled rhodium(I) or iridium(I) complexes in asymmetric catalysis. The major feature of these complexes is the transmission of chirality from distant hydrogen bonded am... |
39925668 | Solar Drying for Domestic and Industrial Applications: A Comprehensive Review of Innovations and Efficiency Enhancements. | Global challenges such as energy scarcity and food security are intensified by a growing population and substantial post-harvest food losses, contributing to alarming hunger levels. Solar drying is recognized as an effective, high-quality, and sustainable method for food preservation, significantly aiding global food s... |
39925667 | Mineral Plastics and Gels from Multi-Arm Ionomers. | Plastic production and waste are a growing menace that affects the soil, the marine environment, and the air in a cumulative manner. The demand for mineral and bioplastics from renewable and biodegradable materials has therefore increased in all relevant sectors. The use of currently available degradable plastics is, h... |
39895707 | Sensitive Electrochemical Immunosensor for Procymidone Detection Based on a Supramolecular Amplification Strategy. | A sensitive electrochemical immunosensor for procymidone detection was developed based on a supramolecular amplification strategy. β-Cyclodextrin (β-CD)-based nanomaterials were employed to immobilize ferrocene derivative (FC)-functionalized antibodies/antigens through host-guest interactions. With the presence of proc... |
39861737 | Design of the Multi-Bioactive Graphene-Oxide/Gelatin/Alginate Scaffolds as Dual ECM-Mimetic and Specific Wound Healing Phase-Target Therapeutic Concept for Advanced Wound Healing. | <b>Objectives:</b> To develop and evaluate graphene oxide/gelatin/alginate scaffolds for advanced wound therapy capable of mimicking the native extracellular matrix (ECM) and bio-stimulating all specific phases of the wound healing process, from inflammation and proliferation to the remodeling of damaged skin tissue in... |
39860781 | A Reusable Capillary Flow-Driven Microfluidic System for Abscisic Acid Detection Using a Competitive Immunoassay. | Point-of-care (PoC) devices offer a promising solution for fast, portable, and easy-to-use diagnostics. These characteristics are particularly relevant in agrifood fields like viticulture where the early detection of plant stresses is crucial to crop yield. Microfluidics, with its low reagent volume requirements, is we... |
39859308 | How Will Nanomedicine Revolutionize Future Dentistry and Periodontal Therapy? | Periodontitis is a prevalent inflammatory disease affecting the supporting structures of the teeth, leading to gum recession, tooth loss, and systemic health complications. Traditional diagnostic methods and treatments, such as clinical evaluation and scaling, often fall short in early detection and targeted therapy, p... |
39858505 | Visual and High-Efficiency Secretion of SARS-CoV-2 Nanobodies with <i>Escherichia coli</i>. | Nanobodies have gained attention as potential therapeutic and diagnostic agents for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to their ability to bind and neutralize the virus. However, rapid, scalable, and robust production of nanobodies for SARS-CoV-2 remains a crucial challenge. In this study,... |
39857914 | Thrombocytopenia in Critically Ill Children: A Review for Practicing Clinicians. | Thrombocytopenia frequently occurs in patients before, during, and after admission to Pediatric Intensive Care Units (PICUs). In critically ill children, it is often due to multifactorial causes and can be a sign of significant organ dysfunction. This review summarizes the potential causes/mechanisms of thrombocytopeni... |
39856882 | Using Commercial Bio-Functional Fungal Polysaccharides to Construct Emulsion Systems by Associating with SPI. | Fungi polysaccharides are nutraceutical-rich compounds with bioactive properties, offering promising applications in food formulation. This study examined the non-covalent complexation of commercial polysaccharides derived from the fruiting bodies of <i>Auricularia auricula-judae</i> (AA) and <i>Ganoderma lucidum</i> (... |
39852720 | Cu<sup>0</sup>-Functionalized, ZIF-8-Derived, Nitrogen-Doped Carbon Composites for Efficient Iodine Elimination in Solution. | The development of copper-based materials with a high efficiency and low cost is desirable for use in iodine (I<sub>2</sub>) remediation. Herein, Cu<sup>0</sup>-nanoparticles-functionalized, ZIF-8 (Zeolite Imidazole Framework-8)-derived, nitrogen-doped carbon composites (Cu@Zn-NC) were synthesized by ball milling and p... |
39852537 | Antioxidant and Anti-Obesity Properties of Acidic and Alkaline Seaweed Extracts Adjusted to Different pH Levels. | This research examined antioxidant and anti-obesity effects of <i>Palmaria palmata</i> extracts obtained through acidic or alkaline treatments and subsequent pH adjustments. After two rounds of acidic or alkaline extraction, the extracts were separated from biomass and adjusted to different pH values: for acidic extrac... |
39852032 | Thermoresponsive Gels with Rosemary Essential Oil: A Novel Topical Carrier for Antimicrobial Therapy and Drug Delivery Applications. | This study investigates the development and comprehensive characterization of innovative thermoresponsive gels incorporating rosemary essential oil (RoEO) encapsulated in poly(lactic-<i>co</i>-glycolic acid) (PLGA) microparticles, with a focus on their potential applications in topical antimicrobial and wound healing t... |
39823916 | Microfluidics-enabled core/shell nanostructure assembly: Understanding encapsulation processes via particle characterization and molecular dynamics. | In the realm of hybrid nanomaterials, the construction of core/shell nanoparticles offer an effective strategy for encompassing a particle by a polymeric or other suitable material, leading to a nanocomposite with distinct features within its structure. The polymer shell can be formed via nanoprecipitation, optimized b... |
39801195 | Synergistic Binding Sites in a Robust and Scalable Metal-Organic Framework for Record CH<sub>4</sub> Capture. | Effectual CH<sub>4</sub> reclamation from CH<sub>4</sub>/N<sub>2</sub> blends by existing physisorbents in industrialization confronts the adversity of frustrated separation performance, weak structural strength, and restricted scale-up preparation. To solve aforesaid bottlenecks, herein, a strategy is presented to fab... |
39801171 | Bioinspired 1D Anisotropic Double-Spiral Metal Wires for Efficient Fog Harvesting. | Innovative design strategies of fog harvesting devices (FHDs) demonstrate promising remedy for water crisis in arid areas. 1D FHDs ensure unimpeded wind circulation and can be manufactured more cost-effectively for extensive regions. Inspired by cactus thorns, desert beetles, and spider silk, two metal organic framewor... |
39801169 | Optimizing the Coordination Energy of Co-N<sub>x</sub> Sites by Co Nanoparticles Integrated with Fe-NCNTs for Boosting PEMFC and Zn-Air Battery Performance. | Enhancing the catalytic performance and durability of M-N─C catalyst is crucial for the efficient operation of proton exchange membrane fuel cells (PEMFCs) and Zn-Air batteries (ZABs). Herein, an approach is developed for the in situ fabrication of a MOFs-derived porous carbon material, co-loaded with Co nanoparticles ... |
39801076 | Viologen-Radical-Driven Hydrogen Evolution from Water Catalyzed by Co-NHC Catalysts: Radical Scavenging by Nitrate and Volmer-Heyrovsky-like CPET Pathway. | The factors controlling the catalytic activity in photochemical hydrogen evolution reaction (HER) are studied in detail for two macrocyclic cobalt compounds bearing two N-heterocyclic carbenes and two pyridyl donors (<b>Co-NHC1</b> and <b>Co-NHC2</b>, where <b>Co-NHC2</b> has a methoxy substituent on each pyridyl ligan... |
39800898 | Biomaterials-mediated biomineralization for tumor blockade therapy. | Recent advancements in tumor therapy have underscored the potential of biomaterials-mediated biomineralization for tumor blockade. By precisely regulating biomineralization and constructing nanomineralized structures at the cellular level, this therapy achieves multi-dimensional targeted inhibition of tumors. Mineraliz... |
39800881 | Computer Simulation of Sulfated Cyclodextrin-Based Enantioselective Separation of Weak Bases With Partial, High-Concentration Filling of the Chiral Selector and Analyte Detection on the Cathodic Side. | Computer simulation was utilized to characterize the electrophoretic processes occurring during the enantioselective capillary electrophoresis-mass spectrometry (CE-MS) analysis of ketamine, norketamine, and hydroxynorketamine in a system with partial filling of the capillary with 19 mM (equals 5%) of highly sulfated γ... |
39800751 | Recent advancements in the diverse roles of polymerase-associated proteins in the replication and pathogenesis of Newcastle disease virus. | Newcastle disease virus (NDV) is a significant member of the Paramyxoviridae family, known for causing epidemics and substantial economic losses in the poultry industry worldwide. The NDV RNA genome primarily encodes six structural proteins (N, P, M, F, HN, and L) and two non-structural proteins (V and W). Among these,... |
39799476 | Amplification-Free Attomolar Detection of Short Nucleic Acids with Upconversion Luminescence: Eliminating Nonspecific Binding by Hybridization Complex Transfer. | The anti-Stokes emission of photon upconversion nanoparticles (UCNPs) facilitates their use as labels for ultrasensitive detection in biological samples as infrared excitation does not induce autofluorescence at visible wavelengths. The detection of extremely low-abundance analytes, however, remains challenging as it i... |
39714445 | The Interplay Between Component Denticity and Flexibility Promotes the Formation of [Ag<sup>I</sup>⋅⋅⋅Ag<sup>I</sup>]-stabilised Links and Knots. | A subtle interplay between the flexibility of the 2,2'-bipyridyl-based diamine and the denticity of the coordination domain formed upon self-assembly enabled the formation of four distinct topologies stabilised by [Ag⋅⋅⋅Ag]<sup>2+</sup> pairs. The reactions utilising 2,6-diformylpyridine resulted in the formation of si... |
39895709 | Crystal Transformation Synthesis of a Three-Dimensional Dual-Fold Building Block Derived from Metal-Organic Framework for Tetracycline Detection. | Metal-organic framework (MOF)-based sensors, which have garnered considerable focus for their potential to enhance environmental monitoring and improve water quality by accurately and consistently identifying antibiotic compounds in water, have gained considerable interest. With the help of pH value, an unusual instanc... |
39877156 | Self-healable and pH-responsive spermidine/ferrous ion complexed hydrogel Co-loaded with CA inhibitor and glucose oxidase for combined cancer immunotherapy through triple ferroptosis mechanism. | Tumor microenvironment governs various therapeutic tolerability of cancer such as ferroptosis and immunotherapy through rewiring tumor metabolic reprogramming like Warburg metabolism. Highly expressed carbonic anhydrases (CA) in tumor that maintaining the delicate metabolic homeostasis is thus the most potential target... |
39877154 | Anisotropic structure of nanofiber hydrogel accelerates diabetic wound healing via triadic synergy of immune-angiogenic-neurogenic microenvironments. | Wound healing in chronic diabetic patients remains challenging due to the multiple types of cellular dysfunction and the impairment of multidimensional microenvironments. The physical signals of structural anisotropy offer significant potential for orchestrating multicellular regulation through physical contact and cel... |
39861244 | The Role of Light Irradiation and Dendrimer Generation in Directing Electrostatic Self-Assembly. | pH-responsive polyamidoamine (PAMAM) dendrimers are used as well-defined building blocks to design light-switchable nano-assemblies in solution. The complex interplay between the photoresponsive di-anionic azo dye Acid Yellow 38 (AY38) and the cationic PAMAM dendrimers of different generations is presented in this stud... |
39859778 | Four-Dimensional Printing of β-Tricalcium Phosphate-Modified Shape Memory Polymers for Bone Scaffolds in Osteochondral Regeneration. | The use of scaffolds for osteochondral tissue regeneration requires an appropriate selection of materials and manufacturing techniques that provide the basis for supporting both cartilage and bone tissue formation. As scaffolds are designed to replicate a part of the replaced tissue and ensure cell growth and different... |
39859303 | Dissecting the Binding Affinity of Anti-SARS-CoV-2 Compounds to Human Transmembrane Protease, Serine 2: A Computational Study. | The human transmembrane protease, serine 2 (TMPRSS2), essential for SARS-CoV-2 entry, is a key antiviral target. Here, we computationally profiled the TMPRSS2-binding affinities of 15 antiviral compounds. Molecular dynamics (MD) simulations for the docked complexes revealed that three compounds exited the substrate-bin... |
39859300 | Special Issue "Advances in Drug Discovery and Synthesis". | In modern medicinal chemistry, drug discovery is a long, difficult, highly expensive and highly risky process for the identification of new drug compounds [...]. |
39859291 | Advancing Inflammatory Bowel Disease Treatment by Targeting the Innate Immune System and Precision Drug Delivery. | Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract. Current immune-modulating therapies are insufficient for 30-50% of patients or cause significant side effects, emphasizing the need for new treatments. Targeting the innate... |
39856877 | The Role of Bitter-Tasting Substances in Salivation and Swallowing: Results of the Pilot Study. | The aim of this study was to investigate the effects of caffeine, vanillin, and epigallocatechin gallate on salivation and swallowing and to find ways to correct their negative effects. Solutions of these substances with an equivalent intensity of bitter taste were compared for this purpose. To compensate for their eff... |
39834658 | Proteomic Identification and Functional Analysis of <i>Babesia microti</i> Reveals Heparin-Binding Proteins. | Glycosaminoglycan (GAG) molecules on the surface of red blood cells play an important regulatory role in the invasion of merozoites of apicomplexan protozoa. Heparan sulfate, a type of GAG molecule, has been identified as an important receptor facilitating the invasion of red blood cells by these parasites. Proteins in... |
39816375 | Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy. | Cancer-associated fibroblasts (CAFs) are a heterogeneous population of non-malignant cells that play a crucial role in the tumor microenvironment, increasingly recognized as key contributors to cancer progression, metastasis, and treatment resistance. So, targeting CAFs has always been considered an important part of c... |
39809023 | Understanding the phase structure evolution and charge storage mechanism of FeCoNi-MOFs as electrodes for asymmetric supercapacitors. | Metal-organic frameworks (MOFs) due to abundant apertures, adjustable components, and multi-purpose structures have broad application prospects in supercapacitors. However, its low conductivity, poor stability, and difficulty growing evenly on the conductive substrate limit the electrochemical energy storage performanc... |
39805456 | Tetracycline removal from aqueous media and hospital wastewater using a magnetic composite of mango lignocellulosic kernel biochar/MnFe<sub>2</sub>O<sub>4</sub>/Cu@Zn-BDC MOF. | This study explored the use of mango lignocellulosic kernel biochar (MKB) modified with MnFe<sub>2</sub>O<sub>4</sub> magnetic nanoparticles and a Cu@Zn-BDC metal-organic framework (MOF) (MKB/MnFe<sub>2</sub>O<sub>4</sub>/Cu@Zn-BDC MOF) for tetracycline (TC) removal from aqueous solutions and hospital wastewater. The m... |
39805422 | The main sources of molecular organization in the cell. Atlas of self-organized and self-regulated dynamic biostructures. | One of the most important goals of contemporary biology is to understand the principles of the molecular order underlying the complex dynamic architecture of cells. Here, we present an overview of the main driving forces involved in the cellular molecular complexity and in the emergent functional dynamic structures, sp... |
39805387 | Interrogation of the tumor microenvironment by nanoparticles. | The tumor microenvironment (TME) plays a pivotal role in cancer progression by fostering intricate multicellular crosstalk among cancer cells, stromal cells, and immune cells. This review explores the emerging paradigm of utilizing nanoparticles to disrupt this crosstalk within the TME as a therapeutic strategy. Nanopa... |
39799341 | Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications. | Immune checkpoint therapies have spearheaded drug innovation over the last decade, propelling cancer treatments toward a new era of precision therapies. Nonetheless, the challenges of low response rates and prevalent drug resistance underscore the imperative for a deeper understanding of the tumor microenvironment (TME... |
39799244 | A Native LH1-RC-HiPIP Supercomplex from an Extremophilic Phototroph. | Halorhodospira (Hlr.) halophila strain BN9622 is an extremely halophilic and alkaliphilic purple phototrophic bacterium and has been widely used as a model for exploring the osmoadaptive and photosynthetic strategies employed by phototrophic extreme halophiles that enable them to thrive in hypersaline environments. Her... |
39799158 | Overrated energy storage performances of dielectrics seriously affected by fringing effect and parasitic capacitance. | Dielectric capacitors are vital for modern power and electronic systems, and accurate assessment of their dielectric properties is paramount. However, in many prevailing reports, the fringing effect near electrodes and parasitic capacitance in the test circuit were often neglected, leading to overrated dielectric perfo... |
39799142 | Sequential addition of cations increases photoluminescence quantum yield of metal nanoclusters near unity. | Photoluminescence is one of the most intriguing properties of metal nanoclusters derived from their molecular-like electronic structure, however, achieving high photoluminescence quantum yield (PLQY) of metal core-dictated fluorescence remains a formidable challenge. Here, we report efficient suppression of the total s... |
39799125 | Tailoring pyridine bridged chalcogen-concave molecules for defects passivation enables efficient and stable perovskite solar cells. | Suppressing deep-level defects at the perovskite bulk and surface is indispensable for reducing the non-radiative recombination losses and improving efficiency and stability of perovskite solar cells (PSCs). In this study, two Lewis bases based on chalcogen-thiophene (n-Bu4S) and selenophene (n-Bu4Se) having tetra-pyri... |
39799105 | Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy. | Hypoxic tumors present a significant challenge in cancer therapy due to their ability to adaptation in low-oxygen environments, which supports tumor survival and resistance to treatment. Enhanced mitophagy, the selective degradation of mitochondria by autophagy, is a crucial mechanism that helps sustain cellular homeos... |
39798012 | Synchronous Interference of Dual Metabolic Pathways Mediated by H<sub>2</sub>S Gas/GOx for Augmenting Tumor Microwave Thermal Therapy. | Sublethal tumor cells have an urgent need for energy, making it common for them to switch metabolic phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) for compensatory energy supply; thus, the synchronous interference of dual metabolic pathways for limiting energy level is essential in inhibiting subl... |
39797825 | Construction of Supramolecular Polymer Network Elastomers Based on Pillar[5]arene/Alkyl Chain Host-Guest Interactions. | As a special kind of supramolecular compound with many favorable properties, pillar[<i>n</i>]arene-based supramolecular polymer networks (SPNs) show potential application in many fields. Although we have come a long way using pillar[<i>n</i>]arene to prepare SPNs and construct a series of smart materials, it remains a ... |
39797813 | Biocompatibility of Phosphorus Dendrimers and Their Antibacterial Properties as Potential Agents for Supporting Wound Healing. | Dendrimers are a wide range of nanoparticles with desirable properties that can be used in many areas of medicine. However, little is known about their potential use in wound healing. This study examined the properties of phosphorus dendrimers that were built on a cyclotriphosphazene core and pyrrolidinium (DPP) or pip... |
39797794 | PACKMOL-GUI: An All-In-One VMD Interface for Efficient Molecular Packing. | PACKMOL is a widely utilized molecular modeling tool within the computational chemistry community. However, its tremendous advantages have been impeded by the longstanding lack of a robust open-source graphical user interface (GUI) that integrates parameter settings with the visualization of molecular and geometric con... |
39797769 | Michael and Schiff-Base Reactions-Assisted Fluorescence Sensor Based on the MOF Nanosheet Microspheres for the Effective Discrimination and Detection of Hydroquinone and Catechol. | A novel sensing platform was constructed for the recognition and identification of dihydroxybenzene isomers based on the MOF-0.02TEA fluorescence sensor with the morphology of nanosheet microspheres through coordination modulation. Based on the sensing principle that the amino group on the MOF-0.02TEA can make the Mich... |
39797561 | Integrative molecular and physiological insights into the phytotoxic impact of liquid crystal monomer exposure and the protective strategy in plants. | Liquid crystal monomers (LCMs), the integral components in the manufacture of digital displays, have engendered environmental concerns due to extensive utilization and intensive emission. Despite their prevalence and ecotoxicity, the LCM impacts on plant growth and agricultural yield remain inadequately understood. In ... |
39797546 | Fracture Risk Assessment in the 2023 Osteoporosis Canada Guideline. | Radiologists and other diagnostic imaging specialists play a pivotal role in the management of osteoporosis, a highly prevalent condition of reduced bone strength and increased fracture risk. Bone mineral density (BMD) measurement with dual-energy X-ray absorptiometry (DXA) is a critical component of identifying indivi... |
39745245 | Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation. | The formation of inclusion complexes between Ginsenoside Rg3 and cyclodextrins represents a promising strategy to enhance the solubility of G-Rg3. Nevertheless, the molecular mechanisms underlying the interaction between G-Rg3 and cyclodextrins have yet to be fully elucidated. In this study, we employed a combination o... |
41675503 | Forging the iron-net: Towards a quantitative understanding of microbial communities via siderophore-mediated interactions. | Iron is a critical yet limited nutrient for microbial growth. To scavenge iron, most microbes produce siderophores-diverse small molecules with high iron affinities. Different siderophores are specifically recognized and uptaken by corresponding recognizers, enabling targeted interventions and intriguing cheater-produc... |
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