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40018453 | Precision Intercalation of Organic Molecules in 2D Layered Materials: From Interface Chemistry to Low-Dimensional Physics. | The past few decades have witnessed significant development in intercalation chemistry research aimed at precisely controlling material properties. Intercalation, as a powerful surface and interface synthesis strategy, facilitates the insertion of external guests into van der Waals (vdW) gaps in two-dimensional (2D) la... |
40017764 | Ultra-Low Optical Loss in Single Crystal Waveguides of Fluorene/Fluorenone Cd<sup>II</sup> Coordination Polymers. | Optical waveguides are essential components in integrated photonic circuits and communication devices. Despite recent advances in both inorganic and organic materials, the use of Coordination Polymers (CPs) as single-crystal optical waveguides remains in its infancy but shows great potential. This study aims to gain in... |
39990862 | Therapeutic Drug Distribution across the Mouse Brain Is Heterogeneous as Revealed by In Vivo, Spatially Resolved Aptamer-Based Sensing. | Drug discovery for central nervous system (CNS) targets is a high stakes process with estimated success rates below ten percent. Dose scaling, penetration through the blood-brain-barrier (BBB), and potency are among the various challenges involved in developing drugs for CNS targets. The standard approach to evaluate s... |
39968139 | Drug repurposing of argatroban, glimepiride and ranolazine shows anti-SARS-CoV-2 activity via diverse mechanisms. | Despite the vast vaccination campaigns against SARS-CoV-2, vaccine-resistant variants have emerged, and COVID-19 is continuing to spread with the fear of emergence of new variants that are resistant to the currently available anti-viral drugs. Hence, there is an urgent need to discover potential host-directed - rather ... |
39949959 | Tat-fimbriae ("tafi"): An unusual type of haloarchaeal surface structure depending on the twin-arginine translocation pathway. | The surface structures of archaeal cells, many of which exist at high temperatures, high salinity, and non-physiological pH, are key factors for their adaptation to extreme living conditions. In the haloarchaeon <i>Haloarcula hispanica</i>, we have discovered a thin filamentous surface appendage called tat-fimbriae ("t... |
39931355 | Recent advances in zeolitic imidazolate frameworks as drug delivery systems for cancer therapy. | Biological nanotechnologies based on functional nanoplatforms have synergistically catalyzed the emergence of cancer therapies. As a subtype of metal-organic frameworks (MOFs), zeolitic imidazolate frameworks (ZIFs) have exploded in popularity in the field of biomaterials as excellent protective materials with the adva... |
39914953 | Elucidation of molecular recognition of catecholamine enantiomer by cyclodextrin combined ion mobility spectrometry and theoretical calculation. | Catecholamines, as important neurotransmitter and clinical drugs, have a wide range of regulatory roles in physiological activities. The recognition of catecholamine enantiomer (CE) and the elucidation of recognition mechanism are of great significance for the in-depth understanding of biomolecular interactions. This w... |
39906797 | Fabricating PCPDTBT/PC61BM organic solar cells using the PVD method. | A study conducted to investigate the fabrication of organic solar cells based on PC61BM:PCPDTBT using the Physical Vapor Deposition (PVD) method. The research carries out a number of analyses for structural evaluations (XRD and ESEM), compositional change (XPS and FTIR), and functional assessment (absorption and I-V te... |
39906203 | Green biosynthetic silver nanoparticles from <i>Ageratum conyzoides</i> as multifunctional hemostatic agents: Combining hemostasis, antibacterial, and anti-inflammatory properties for effective wound healing. | Widespread interest in new hemostatic agents arises from the challenge of simultaneously satisfying the requirements of hemostatic, antibacterial, and anti-inflammatory properties while also considering the associated economic costs. An ideal hemostasis material should facilitate rapid hemostasis, intervene against inf... |
39897885 | Design of therapeutic siRNAs for potential application to infection with chikungunya virus. | Emergence of the Chikungunya virus (CHIKV) is a new threat in the world. The disastrous effect of this virus and the unavailability of specific drugs complicated the control and management of the disease. The development of a siRNA-based drug using multiple computational tools could be a way out as one of its therapeut... |
39897864 | Bi-polymeric structured system (xanthan gum-carboxymethyl cellulose) for developing instant powder with the ability to suspend flixweed seeds in beverages: Effect of pH and sweetener type. | Creating innovation in the production of beverage products has always been one of the goals of this industry. This investigation studied the fabrication of an instant biopolymeric structured powder to suspend flixweed seeds in a beverage. A mixture of carboxymethyl cellulose (CMC) and xanthan (XG) hydrocolloids in diff... |
39897825 | A review on surface modification of nanofibrous textiles for diverse applications: Focus on medical uses. | Electrospun nanofibers with a high surface area are attractive materials for biomedical applications. They have potential use in scaffolds, drug delivery, bio face masks, wound dressings, and biosensors. Various surface modifications have been developed to improve their chemical and physical properties. These modificat... |
39897799 | Interferon-γ production in response to the cytotoxic T lymphocyte epitope within an antigen incorporated in simian virus 40 virus-like particles. | In a previous study, we showed that administration of antigen-incorporated virus-like particles (VLPs) derived from simian virus 40 (SV40) induces production of cytotoxic T lymphocytes (CTL), as well as antibodies against the incorporated antigen(s), without the need for an adjuvant; however, it remains unclear how imm... |
39897787 | Drug delivery strategies to improve the treatment of corneal disorders. | Anterior eye disorders including dry eye syndrome, keratitis, chemical burns, and trauma have varying prevalence rates in the world. Classical dosage forms based-topical ophthalmic drugs are popular treatments for managing corneal diseases. However, current dosage forms of ocular drugs can be associated with major chal... |
39896260 | Benchmarking the robustness of the correct identification of flexible 3D objects using common machine learning models. | True three-dimensional (3D) data are prevalent in domains such as molecular science or computer vision. In these data, machine learning models are often asked to identify objects subject to intrinsic flexibility. Our study introduces two datasets from molecular science to assess the classification robustness of common ... |
39895831 | Deep plasma and tissue proteome profiling of knockout mice reveals pathways associated with <i>Svep1</i> deficiency. | Despite strong causal associations with cardiovascular and metabolic disorders including coronary artery disease, hypertension, and type 2 diabetes, as well as a range of other diseases, the exact function of the protein SVEP1 remains largely unknown. Animal models have been employed to investigate how SVEP1 contribute... |
39877688 | Exploring the noncovalent interaction between β-lactoglobulin and flavonoids under nonthermal process: Characterization, physicochemical properties, and potential for lycopene delivering. | The poor structure stability and low bioavailability of lycopene (LY) hampers the wide application in food field. Thus, it is crucial to explore novel deliver carrier for LY based on protein-flavonoid complexes. In this study, the noncovalent interaction mechanism between β-lactoglobulin (β-LG) and flavonoids (apigenin... |
39877607 | Highly sensitive non-enzymatic glucose sensing using Ni nanowires and graphene thin film on the gate area of extended gate electric double-layer field-effect transistor. | This study presents an innovative glucose detection platform, featuring a highly sensitive, non-enzymatic glucose sensor. The sensor integrates nickel nanowires and a graphene thin film deposited on the gate region of an extended-gate electric double-layer field-effect transistor (EGEDL-FET). This unique combination of... |
39877604 | Removal of Cr(VI) from aqueous solutions by activated carbon and its composite with P<sub>2</sub>W<sub>17</sub>O<sub>61</sub>: A spectroscopic study to reveal adsorption mechanism. | Molecular scale information is needed to understand ions coordination to mineral surfaces and consequently to accelerate the design of improved adsorbents. The present work reports on the use of two-dimensional correlation Fourier Transform infra-red spectroscopy (2D-COS-FTIR) and hetero 2D-COS-FTIR- X-ray diffraction ... |
39867656 | Targeting the initiator to activate both ferroptosis and cuproptosis for breast cancer treatment: progress and possibility for clinical application. | Breast cancer is the most commonly diagnosed cancer worldwide. Metal metabolism is pivotal for regulating cell fate and drug sensitivity in breast cancer. Iron and copper are essential metal ions critical for maintaining cellular function. The accumulation of iron and copper ions triggers distinct cell death pathways, ... |
39867593 | A genetically encoded fluorescent biosensor for sensitive detection of cellular c-di-GMP levels in <i>Escherichia coli</i>. | Cyclic di-guanosine monophosphate (c-di-GMP) acts as a second messenger regulating bacterial behaviors including cell cycling, biofilm formation, adhesion, and virulence. Monitoring c-di-GMP levels is crucial for understanding these processes and designing inhibitors to combat biofilm-related antibiotic resistance. Her... |
39867472 | Therapeutic functions of medical implants from various material categories with integrated biomacromolecular systems. | Medical implants are designed to replace missing parts or improve body functions and must be capable of providing structural support or therapeutic intervention for a medical condition. Advances in materials science have enabled the development of devices made from metals, polymers, bioceramics, and composites, each wi... |
39867471 | An injectable, self-healing, anti-infective, and anti-inflammatory novel glycyrrhizic acid hydrogel for promoting acute wound healing and regeneration. | <h4>Introduction</h4>Bacterial infection, a complex wound microenvironment, and a persistent inflammatory response in acute wounds can result in delayed healing and abnormal scar formation, thereby compromising the normal function and aesthetic appearance of skin tissue. This issue represents one of the most challengin... |
39866909 | The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases. | Multiple sclerosis (MS) is a chronic central nervous system (CNS) disease with demyelinating inflammatory characteristics. It is the most common nontraumatic and disabling disease affecting young adults. The incidence and prevalence of MS have been increasing. However, its exact cause remains unclear. The main tests us... |
39866698 | Strand-Swapped SH3 Domain Dimer with Superoxide Dismutase Activity. | The design of metalloproteins allows us to better understand metal complexation in proteins and the resulting function. In this study, we incorporated a Cu<sup>2+</sup>-binding site into a natural protein domain, the 58 amino acid c-Crk-SH3, to create a miniaturized superoxide dismutase model, termed SO1. The resulting... |
39866315 | Transcriptomic and metabolomic analysis reveals the molecular mechanism of exogenous melatonin improves salt tolerance in eggplants. | <h4>Introduction</h4>Melatonin significantly enhances the tolerance of plants to biotic and abiotic stress, and plays an important role in plant resistance to salt stress. However, its role and molecular mechanisms in eggplant salt stress resistance have been rarely reported. In previous studies, we experimentally demo... |
39861233 | Development of Molecularly Imprinted Photonic Crystals Sensor for High-Sensitivity, Rapid Detection of Sulfamethazine in Food Samples. | As a veterinary drug, sulfamethazine is frequently used to control animal diseases. In this study, a novel molecularly imprinted photonic crystal sensor for the fast visual detection of sulfamethazine in milk and chicken has been developed. Under optimum preparation conditions, a molecularly imprinted, photonic crystal... |
39861237 | Cellulose-Based Materials and Their Application in Lithium-Sulfur Batteries. | Lithium-sulfur (Li-S) batteries are promising candidates for next-generation energy storage due to their high energy density, cost-effectiveness, and environmental friendliness. However, their commercialization is hindered by challenges, such as the polysulfide shuttle effect, lithium dendrite growth, and low electrica... |
39860124 | Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application. | pH sensitivity of chitosan allows for precise phase transitions in acidic environments, controlling swelling and shrinking, making chitosan suitable for drug delivery systems. pH transitions are modulated by the presence of cross-linkers by the functionalization of the chitosan chain. This review relays a summary of ch... |
39860119 | Albumin as an Effective Auxiliary Agent for the Enriched Extraction of Anthraquinones and Curcumin from Plant Matrices. | Nowadays, several processes to enrich desired bioactive compounds in plant extracts have been developed. The objective of the present study was to assess the performance of bovine serum albumin in increasing the extractive yields of anthraquinones and diarylheptanoids from their respective raw plant powder extracts. Al... |
39860121 | Recent Progress in Enzyme Immobilization to Metal-Organic Frameworks to Enhance the CO<sub>2</sub> Conversion Efficiency. | Climate change and the energy crisis, driven by excessive CO<sub>2</sub> emissions, have emerged as pressing global challenges. The conversion of CO<sub>2</sub> into high-value chemicals not only mitigates atmospheric CO<sub>2</sub> levels but also optimizes carbon resource utilization. Enzyme-catalyzed carbon technolo... |
39860118 | Development of Homogeneous Carboxylation of Phenolates via Kolbe-Schmitt Reaction. | In this study, the homogeneous carboxylation of potassium, sodium, and lithium phenolates in DMSO solution at 100 °C by the Kolbe-Schmitt reaction was investigated. The impact of water, phenolate concentration, and cation nature on the yield of products and reaction selectivity was demonstrated. Based on the patterns o... |
39859753 | Innovative Supported Membranes for Ion Mobility Spectrometer (IMS) Sample Introduction Systems with High Permeability Relative to Toxic Agents in Air (TAAs). | One of the main objectives of the ion mobility spectrometry (IMS) technique is to reduce moisture in detection systems, which causes the formation of ion clusters and ion water and a reduction in formed clusters' activity. Thus, one of the methods limiting moisture in a sampling injection system is to use hydrophobic p... |
39859284 | Enhancing the Solubility and Dissolution of Apigenin: Solid Dispersions Approach. | Apigenin (APG), a bioactive flavonoid with promising therapeutic potential, suffers from poor water solubility, which limits its bioavailability. To address this, solid dispersions of APG were prepared using ball milling with sodium alginate (SA), Pluronic<sup>®</sup> F-68 (PLU68), Pluronic<sup>®</sup> F-127 (PLU127), ... |
39859264 | Enhancing Industrial Hemp (<i>Cannabis sativa</i>) Leaf By-Products: Bioactive Compounds, Anti-Inflammatory Properties, and Potential Health Applications. | The sustainable utilization of biomass-derived bioactives addresses the growing demand for natural health products and supports sustainable development goals by reducing reliance on synthetic chemicals in healthcare. <i>Cannabis sativa</i> biomass, in particular, has emerged as a valuable resource within this context. ... |
39859254 | Pyrrolysine Aminoacyl-tRNA Synthetase as a Tool for Expanding the Genetic Code. | In addition to the 20 canonical amino acids encoded in the genetic code, there are two non-canonical ones: selenocysteine and pyrrolysine. The discovery of pyrrolysine synthetases (PylRSs) was a key event in the field of genetic code expansion research. The importance of this discovery is mainly due to the fact that th... |
39858178 | <i>Fasciola gigantica</i> Recombinant Abelson Tyrosine Protein Kinase (r<i>Fg</i>Abl) Regulates Various Functions of Buffalo Peripheral Blood Mononuclear Cells. | <i>Fasciola gigantica</i> can modulate host immune mechanisms through excretory-secretory products (ESP). As one of the components of ESP, it is unknown whether Abelson tyrosine protein kinase (Abl) is involved in parasite-host immune interaction. To investigate the immunoregulatory function of Abl in <i>Fasciola gigan... |
39858173 | Integrating Metabolomics and Genomics to Uncover the Impact of Fermented Total Mixed Ration on Heifer Growth Performance Through Host-Dependent Metabolic Pathways. | With the increasing demand for enhancing livestock production performance and optimizing feed efficiency, this study aimed to investigate the effects of fermented total mixed ration (FTMR) containing different proportions of rice straw and sheath and leaves of <i>Zizania latifolia</i> on systemic nutrient metabolism an... |
39857280 | Transcriptomic Insights into Dual Temperature-Salinity Stress Response in "Shuike No. 1", a Pioneering Rainbow Trout Strain Bred in China. | Global warming poses a significant threat to aquaculture, particularly for cold-water species like rainbow trout (<i>Oncorhynchus mykiss</i>). Understanding the molecular mechanisms underlying stress responses is crucial for developing resilient strains. This study investigates the dual stress of salinity and temperatu... |
39856876 | An Experimental and Computational Study on the Effects of Ball Milling on the Physicochemical Properties and Digestibility of a Canna Starch/Tea Polyphenol Complex. | To investigate the impact of tea polyphenols on the thermodynamic properties, gelatinization properties, rheological properties, and digestion characteristics of starch after ball milling, canna starch and tea polyphenols were mixed at a 10:1 ratio (<i>w</i>/<i>w</i>) in an experiment and processed with different ball ... |
39856874 | Sources of Lipopeptides and Their Applications in Food and Human Health: A Review. | Lipopeptides (LPs) are widely sourced surface-active natural products with a wide range of functions and low toxicity, high potency, and good biodegradability. In this paper, we summarize, for the first time, the plant, animal, microbial, and synthetic sources of LPs. We also introduce the applications of LPs in food a... |
39856866 | The Impact of Oyster Mushrooms (<i>Pleurotus ostreatus</i>) on the Baking Quality of Rye Flour and Nutrition Composition and Antioxidant Potential of Rye Bread. | This study aimed to evaluate the use of oyster mushroom (<i>Pleurotus ostreatus</i>) powder (OMP) for producing rye bread. The raw materials were low-extract rye flour and OMP, which were analyzed in terms of their nutritional and health-promoting qualities. Mixtures of rye flour with OMP were prepared, replacing 5, 7.... |
39852089 | Integration of Functional Materials in Photonic and Optoelectronic Technologies for Advanced Medical Diagnostics. | Integrating functional materials with photonic and optoelectronic technologies has revolutionized medical diagnostics, enhancing imaging and sensing capabilities. This review provides a comprehensive overview of recent innovations in functional materials, such as quantum dots, perovskites, plasmonic nanomaterials, and ... |
39852088 | Recent Progress in Self-Healing Triboelectric Nanogenerators for Artificial Skins. | Self-healing triboelectric nanogenerators (TENGs), which incorporate self-healing materials capable of recovering their structural and functional properties after damage, are transforming the field of artificial skin by effectively addressing challenges associated with mechanical damage and functional degradation. This... |
39845871 | Engineering perfluoroarenes for enhanced molecular barrier effect and chirality transfer in solutions. | Noncovalent forces have a significant impact on photophysical properties, and the flexible employment of weak forces facilitates the design of novel luminescent materials with a variety of applications. The arene-perfluoroarene (AP) force, as one type of π-hole/π interaction, shows unique directionality, involving an e... |
39845272 | A Case of Radical Resection of Esophageal Basaloid Cell Carcinoma After Hemostasis by Transarterial Embolization. | Esophageal bleeding management typically involves endoscopy but becomes challenging with large or hemorrhagic tumors, especially in cases of rare basal cell carcinoma. This malignancy, with a poorer prognosis than squamous cell carcinoma, often requires definitive surgery. A 78-year-old man with severe hematemesis unde... |
39827820 | Development of a Silver-Based MOF Oxidase-Like nanozyme modified with molecularly imprinted polymer for sensitive and selective colorimetric detection of quercetin. | Antioxidants are vital components in various food, plant, and pharmacological products, making their quantitative, selective, and straightforward assessment essential for evaluating product quality and health benefits. Nanozymes, such as metal-organic frameworks (MOFs) with enzyme-like catalytic activity, hold signific... |
39826273 | CIMNE-CRISPR: A novel amplification-free diagnostic for rapid early detection of African Swine Fever Virus. | African Swine Fever Virus (ASFV) is a highly contagious pathogen with nearly 100% mortality in swine, causing severe global economic loss. Current detection methods rely on nucleic acid amplification, which requires specialized equipment and skilled operators, limiting accessibility in resource-constrained settings. To... |
39824014 | A paper-based SERS/colorimetry substrate for reliable detection. | For on-site analysis, the combination of surface enhanced Raman scattering (SERS) and colorimetry, as a dual-mode detection, can effectively improve the accuracy of detection, and reduce the influence of instrument fluctuation, which greatly improves the accuracy and reliability of the results. However, the preparation... |
39823954 | Engineering Defect-Mediated S-scheme heterojunctions in MOF-Derived N-doped NiO porous microrods and ZnIn<sub>2</sub>S<sub>4</sub> nanosheets for superior photocatalytic hydrogen evolution. | The development of efficient photocatalysts inspired by natural photosynthesis has drawn considerable interest for sustainable hydrogen (H<sub>2</sub>) production. Among the various strategies for enhancing H<sub>2</sub> evolution, constructing step-scheme (S-scheme) heterojunctions has attracted extensive interest, th... |
39823904 | A novel electronic nose for sensing (E)-2-hexenal based on Mn-MOF nanonets with NADPH-like activity. | Bioreceptors are increasingly popular for selective aroma sensing but face challenges with receptor separation and cell culture. Here, we developed a bioreceptor-free electronic nose employing Mn-metal organic framework (Mn-MOF) nanonets as sensing materials for rapid electrochemical quantification of (E)-2-hexenal, a ... |
39813449 | Access pathways to the transsexualizing process in Brazil: a scoping review. | <h4>Objective</h4>To analyze the representation of access pathways to the transsexualizing process in Brazil and the main barriers faced by transgender people.<h4>Method</h4>A scoping review of the literature was conducted. Searches took place in January 2024, with articles and reviews that addressed access to the tran... |
39816240 | Urogenital Manifestations in Mpox (Monkeypox) Infection: A Comprehensive Review of Epidemiology, Pathogenesis, and Therapeutic Approaches. | Monkeypox (mpox), caused by mpox virus (MPXV) infection, reemerged in 2022 and still raises concerns globally. Abundant clinical data indicate that mpox is a sexually transmitted infection and that the urogenital system is the most frequently involved system in mpox, which deserves more attention. Penile lesions are th... |
39813784 | An innovative strategy for constructing multicore yolk-shell Si/C anodes for lithium-ion batteries. | The yolk-shell architecture offers a promising solution to the challenges of silicon (Si) anodes in lithium-ion batteries (LIBs), particularly in addressing the significant volume changes that occur during charge and discharge cycles. However, traditional construction methods often rely on sacrificial templates and aci... |
39811102 | Fat Liquefaction and Lipo Particles in a CIED Pocket During Generator Change-Not an Infection: A Rare Case Report. | A case of fat liquefaction and fat particles in the pacemaker pocket observed in a female patient 12 years after implantation. The patient had no symptoms and no signs of infection or other discomfort of the heart and pacemaker pocket. The biochemical analysis showed a slight increase in cardiac troponin T, 0.026 ng/mL... |
39809069 | Cucurbit[6]uril host-guest interaction assisted N-terminal epitope imprinted particles for cytochrome c recognition prepared by reversible addition-fragmentation chain transfer strategy. | A novel strategy for cytochrome c selective recognition assisted with cucurbit[6]uril by host-guest interaction via N-terminal epitope imprinting and reversible addition-fragmentation chain transfer (RAFT) polymerization was developed. N-terminal nonapeptide of cytochrome c (GI-9) was used as the epitope template to ac... |
39805202 | Single-molecule resolution of the conformation of polymers and dendrimers with solid-state nanopores. | Polymers and dendrimers are macromolecules, possessing unique and intriguing characteristics, that are widely applied in self-assembled functional materials, green catalysis, drug delivery and sensing devices. Traditional approaches for the structural characterization of polymers and dendrimers involve DLS, GPC, NMR, I... |
39802641 | Avian influenza overview September-December 2024. | Between 21 September and 6 December 2024, 657 highly pathogenic avian influenza (HPAI) A(H5N1) and A(H5N5) virus detections were reported in domestic (341) and wild (316) birds across 27 countries in Europe. Many HPAI outbreaks in domestic birds were clustered in areas with high poultry density and characterised by sec... |
39802478 | Enhanced performance of UiO-66 for supercapacitor applications through oxidation <i>via</i> the Hummers' method. | Supercapacitors (SCs) are gaining attention in energy storage due to their high-power density, rapid charge/discharge ability, and long life cycle. Improving these features relies on developing advanced electrode materials with better energy storage properties. This study explores UiO-66, a zirconium-based metal-organi... |
39801503 | Finely Tailored Conjugated Small Molecular Nanoparticles for Near-Infrared Biomedical Applications. | Near-infrared (NIR) phototheranostics (PTs) show higher tissue penetration depth, signal-to-noise ratio, and better biosafety than PTs in the ultraviolet and visible regions. However, their further advancement is severely hindered by poor performances and short-wavelength absorptions/emissions of PT agents. Among repor... |
39800291 | Synthesis and characterization of advanced Ad-UiO-66@NGO composite for efficient CO<sub>2</sub> capture and CO<sub>2</sub>/N<sub>2</sub> adsorption selectivity. | Highly effective adsorbents, with their impressive adsorption capacity and outstanding selectivity, play a pivotal role in technologies such as carbon capture and utilization in industrial flue gas applications, leading to significant reductions in greenhouse gas emissions. This study aims to synthesize advanced compos... |
39800297 | Ultrasensitive quantification of neonicotinoid thiamethoxam in environment using MOF-derived CuCo<sub>2</sub>O<sub>4</sub>/3D rGO based electrochemical sensor integrated with optimized neural network. | Accurate quantification of neonicotinoid insecticides is pivotal to ensure environmental safety by examining and mitigating their potential harmful effects on pollinators and aquatic ecosystems. In this scenario, detection of neonicotinoid insecticide, thiamethoxam (TMX), is significant for safeguarding ecological bala... |
39800164 | Immobilization of glycosyltransferase into a hydrophilic metal-organic framework for efficient biosynthesis of chondroitin sulfate. | Chondroitin sulfate (CS) is a structurally complex anionic polysaccharide widely used in medical, cosmetic and food applications. Enzymatic catalysis is an important strategy for synthesizing CS with uniform chain lengths and well-defined structures. However, the industrial application of glycosyltransferases is hinder... |
39800098 | Reversible light-responsive protein hydrogel for on-demand cell encapsulation and release. | The design of biomaterials that can reconfigure on-demand in response to external stimuli is an emerging area in materials research. However, achieving reversible assembly of protein-based biomaterials by light input remains a major challenge. Here, we present the engineering of a new protein material that is capable o... |
39800001 | Thermosensitive-based synergistic antibacterial effects of novel LL37@ZPF-2 loaded poloxamer hydrogel for infected skin wound healing. | Trauma healing is the process of healing after the body has been subjected to an external force and the skin and other tissues have become dissected or defective, showing the synergistic effect of various processes. Therefore, the investigation of innovative wound dressings has significant research and clinical implica... |
39799064 | Advances of Hydroxyapatite Nanoparticles in Dental Implant Applications. | Hydroxyapatite nanoparticles (HANPs) are becoming increasingly crucial in dental implant applications as they are highly compatible with biological systems, actively support biological processes, and closely resemble bone minerals. This review covers the latest progress in how HANPs are made, studied, and used in denti... |
39798874 | Specific recognition mechanism of an antibody to sulfated tyrosine and its potential use in biological research. | Post-translational modification of proteins is a crucial biological reaction that regulates protein functions by altering molecular properties. The specific detection of such modifications in proteins has made significant contributions to molecular biology research and holds potential for future drug development applic... |
39798765 | Synthesis of zirconium-based metal-organic framework/gelatin aerogel for removing phosphate and fluoride from aqueous solutions. | This study describes the preparation of novel hybrid aerogels derived from gelatin (Gel), incorporating Br-functionalized zirconium-based metal-organic framework (UiO-66-Br; MOF) as modifying agent to effectively eliminate phosphate and fluoride ions from aqueous environments. The adsorption performance of MOF decorate... |
39798637 | Synergistic effects of NO/H<sub>2</sub>S gases on antibacterial, anti-inflammatory, and analgesic properties in oral ulcers using a gas-releasing nanoplatform. | Oral mucosal wounds are more prone to inflammation due to direct exposure to various microorganisms. This can result in pain, delayed healing, and other complications, affecting patients' daily activities such as eating and speaking. Consequently, the overall quality of life for patients is significantly reduced. To ad... |
39797481 | Spindle-Shaped Ni-Fe-Layered Double Hydroxide: Effect of Etching Time on Flexible Energy Storage. | The rising demand for efficient energy storage in flexible electronics is driving the search for materials that are well-suited for the fabrication of these devices. Layered Double Hydroxides (LDHs) stand out as a remarkable material with a layered structure that embodies exceptional electrochemical properties. In this... |
39797479 | Self-Sustained Biophotocatalytic Nano-Organelle Reactors with Programmable DNA Switches for Combating Tumor Metastasis. | Metastasis, the leading cause of mortality in cancer patients, presents challenges for conventional photodynamic therapy (PDT) due to its reliance on localized light and oxygen application to tumors. To overcome these limitations, a self-sustained organelle-mimicking nanoreactor is developed here with programmable DNA ... |
39797477 | Protein-Guided Biomimetic Calcification Constructing 3D Nitrogen-Rich Core-Shell Structures Realizing High-Performance Lithium-Sulfur Batteries. | Biomimetic calcification is a micro-crystallization process that mimics the natural biomineralization process, where biomacromolecules regulate the formation of inorganic minerals. In this study, it is presented that a protein-assisted biomimetic calcification method for the in situ synthesis of nitrogen-doped metal-or... |
39797443 | Multiscale Understanding of Anion Exchange Membrane Fuel Cells: Mechanisms, Electrocatalysts, Polymers, and Cell Management. | Anion exchange membrane fuel cells (AEMFCs) are among the most promising sustainable electrochemical technologies to help solve energy challenges. Compared to proton exchange membrane fuel cells (PEMFCs), AEMFCs offer a broader choice of catalyst materials and a less corrosive operating environment for the bipolar plat... |
39797428 | Co-assemblies of Silver Nanoclusters and Fullerenols With Enhanced Third-Order Nonlinear Optical Response. | Exploring potential third-order nonlinear optical (NLO) materials attracts ever-increasing attention. Given that the atomically precise and rich adjustable structural features of silver nanoclusters (Ag NCs), as well as the unique π-electron conjugated system of carbon-based nanomaterials, a supramolecular co-assembly ... |
39794808 | Discovery of 15-deoxynaphthomycins activating the antioxidant NRF2-ARE pathway from Streptomyces sp. N50 via genome mining, global regulator introduction, and molecular networking. | Genome mining is a promising avenue for expanding the repertoire of microbial natural products, which are important for drug development. This approach involves predicting genetically encoded small molecules by examining bacterial genomes via accumulated knowledge of microbial biosynthesis. However, it is also importan... |
39794773 | Silk-engineered bioactive nanoparticles for targeted alleviation of acute inflammatory disease via macrophage reprogramming. | Significant progress has been made in the development of potential therapies for diseases associated with inflammation and oxidative stress. Nevertheless, the availability of effective clinical treatments remains limited. Herein, we introduce a novel silk-based bioactive material, TPSF, developed by sequentially conjug... |
39794466 | Comprehensive discovery and functional characterization of the noncanonical proteome. | The systematic identification and functional characterization of noncanonical translation products, such as novel peptides, will facilitate the understanding of the human genome and provide new insights into cell biology. Here, we constructed a high-coverage peptide sequencing reference library with 11,668,944 open rea... |
39794457 | Oral colon-targeted responsive chitosan/pectin-based nanoparticles propels the application of tofacitinib in colitis therapy. | Tofacitinib (Tof), a commercially available pan-Janus kinases inhibitor, is approved for the treatment of moderate to severe ulcerative colitis. However, its clinical application is limited due to dose-dependent systemic side effects. The present study aims to develop an efficient oral colon-targeted drug delivery syst... |
39794423 | Designing cellulose based biochars for CO<sub>2</sub> separation using molecular simulations. | This study investigates the pyrolysis mechanism of cellulose using reactive molecular dynamics simulations to prepare biochars for CO<sub>2</sub> separation applications. Six biochars with densities ranging from 0.160 to 0.987 g/cm³ were prepared, and their performance in adsorbing CO<sub>2</sub>, CH<sub>4</sub>, and N... |
39794356 | Optical tuning of polymer functionalized zinc oxide quantum dots as a selective probe for the detection of antibiotics. | Excess consumption of antibiotics leads to antibiotic resistance that hinders the control and cure of microbial diseases. Therefore, it is crucial to monitor the antibiotic levels in the environment. In this proposed research work, an optical nano-sensor was devised that can sense the ultra-low concentration of antibio... |
39794349 | Heterochromatic gene silencing controls CD4<sup>+</sup> T cell susceptibility to regulatory T cell-mediated suppression in a murine allograft model. | Protective immune responses require close interactions between conventional (Tconv) and regulatory T cells (Treg). The extracellular mediators and signaling events that regulate the crosstalk between these CD4<sup>+</sup> T cell subsets have been extensively characterized. However, how Tconv translate Treg-dependent su... |
39794308 | Low-carbon indoor humidity regulation via 3D-printed superhygroscopic building components. | Indoor humidity can significantly impact our comfort and well-being, often leading to the use of mechanical systems for its management. However, these systems can result in substantial carbon emissions and energy precarity. This study offers an alternative: using low-carbon materials that naturally buffer moisture to p... |
39793973 | On-Surface Synthesis and Characterization of Radical Spins in Kagome Graphene. | Flat bands in Kagome graphene might host strong electron correlations and frustrated magnetism upon electronic doping. However, the porous nature of Kagome graphene opens a semiconducting gap due to quantum confinement, preventing its fine-tuning by electrostatic gates. Here we induce zero-energy states into a semicond... |
39793028 | Advancing the Mechanosensitivity of Atropisomeric Diarylethene Mechanophores through a Lever-Arm Effect. | Understanding structure-mechanical activity relationships (SMARs) in polymer mechanochemistry is essential for the rational design of mechanophores with desired properties, yet SMARs in noncovalent mechanical transformations remain relatively underexplored. In this study, we designed a subset of diarylethene mechanopho... |
39792956 | Mechanistic Investigations of Cobalt-Catalyzed, Aminoquinoline-Directed C(sp<sup>2</sup>)-H Bond Functionalization. | Monoanionic, bidentate-auxiliary-directed, cobalt-catalyzed C-H bond functionalization has become a very useful tool in organic synthesis. A comprehensive investigation into isolated organometallic intermediates and their reactivity within the catalytic cycle is lacking. We report here mechanistic studies of cobalt-cat... |
39792889 | Identification of biomarkers associated with ferroptosis in macrophages infected with Mycobacterium abscessus using bioinformatic tools. | Mycobacterium abscessus is a rapidly growing nontuberculous mycobacterium that causes severe pulmonary infections. Recent studies indicate that ferroptosis may play a critical role in the pathogenesis of M. abscessus pulmonary disease. We obtained gene expression microarray data from the Gene Expression Omnibus databas... |
39792829 | Immunoinformatics design of a novel multiepitope vaccine candidate against non-typhoidal salmonellosis caused by Salmonella Kentucky using outer membrane proteins A, C, and F. | The global public health risk posed by Salmonella Kentucky (S. Kentucky) is rising, particularly due to the dissemination of antimicrobial resistance genes in human and animal populations. This serovar, widespread in Africa, has emerged as a notable cause of non-typhoidal gastroenteritis in humans. In this study, we us... |
39792832 | Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single-Component Organic Phototherapeutic Agents. | Photodynamic therapy (PDT) and photothermal therapy (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic and nononcologic diseases. Single-component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, inc... |
39792791 | Long, Synthetic <i>Staphylococcus aureus</i> Type 8 Capsular Oligosaccharides Reveal Structural Epitopes for Effective Immune Recognition. | <i>Staphylococcus aureus</i> is a Gram-positive bacterium that is responsible for severe nosocomial infections. The rise of multidrug-resistant strains, which can pose significant health threats, prompts the development of new treatment interventions, and much attention has been directed at the development of prophylac... |
39792793 | Highly Self-Adhesive and Biodegradable Silk Bioelectronics for All-In-One Imperceptible Long-Term Electrophysiological Biosignals Monitoring. | Skin-like bioelectronics offer a transformative technological frontier, catering to continuous and real-time yet highly imperceptible and socially discreet digital healthcare. The key technological breakthrough enabling these innovations stems from advancements in novel material synthesis, with unparalleled possibiliti... |
39792782 | Machine Learning-Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug-Drug Self-Assembly. | Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self-assembling nanomedicines, employing physiochemical parameters to predi... |
39792775 | Supramolecular Engineering of Nanoceria for Management and Amelioration of Age-Related Macular Degeneration via the Two-Level Blocking of Oxidative Stress and Inflammation. | Age-related macular degeneration (AMD), characterized by choroidal neovascularization (CNV), is the global leading cause of irreversible blindness. Current first-line therapeutics, vascular endothelial growth factor (VEGF) antagonists, often yield incomplete and suboptimal vision improvement, necessitating the explorat... |
39792672 | Morphogen-induced kinase condensates transduce Hh signal by allosterically activating Gli. | Hedgehog (Hh) morphogen governs embryonic development and tissue homeostasis through the Ci/Gli family transcription factors. Here we report that Hh induces phase separation of the fused (Fu)/Ulk family kinases to allosterically regulate Ci/Gli. We find that Hh-induced phosphorylation of Fu/Ulk3 promotes SUMOylation of... |
39792661 | Chromatin conformation, gene transcription, and nucleosome remodeling as an emergent system. | In single cells, variably sized nanoscale chromatin structures are observed, but it is unknown whether these form a cohesive framework that regulates RNA transcription. Here, we demonstrate that the human genome is an emergent, self-assembling, reinforcement learning system. Conformationally defined heterogeneous, nano... |
39792660 | Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells. | Chimeric antigen receptor T cells (CART) targeting CD19 through CD28.ζ signaling induce rapid lysis of leukemic blasts, contrasting with persistent tumor control exhibited by 4-1BB.ζ-CART. We reasoned that molecular dynamics at the CART immune synapse (CARIS) could explain differences in their tumor rejection kinetics.... |
39792653 | Sequential Targeting Chondroitin Sulfate-Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages. | The infiltration and excessive polarization of M1 macrophages contribute to the induction and persistence of low-grade inflammation in joint-related degenerative diseases such as osteoarthritis (OA). The lipid metabolism dysregulation promotes M1 macrophage polarization by coordinating the compensatory pathways of the ... |
39792643 | Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | Older individuals experience increased susceptibility and mortality to bacterial infections, but the underlying etiology remains unclear. Herein, it is shown that aging-associated reduction of commensal Parabacteroides goldsteinii (P. goldsteinii) in both aged mice and humans critically contributes to worse outcomes of... |
39792637 | Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis. | Regulatory T cells (T<sub>regs</sub>) accumulate in the visceral adipose tissue (VAT) to maintain systemic metabolic homeostasis but decline during obesity. Here, we explored the metabolic pathways controlling the homeostasis, composition, and function of VAT T<sub>regs</sub> under normal and high-fat diet feeding cond... |
39792612 | Genetically Programmed Single-Component Protein Hydrogel for Spinal Cord Injury Repair. | Protein self-assembly allows for the formation of diverse supramolecular materials from relatively simple building blocks. In this study, a single-component self-assembling hydrogel is developed using the recombinant protein CsgA, and its successful application for spinal cord injury repair is demonstrated. Gelation is... |
39792598 | From Monocyclization to Pentacyclization: A Versatile Plant Cyclase Produces Diverse Sesterterpenes with Anti-Liver Fibrosis Potential. | A prolific multi-product sesterterpene synthase CbTPS1 is characterized from the medicinal Brassicaceae plant Capsella bursa-pastoris. Twenty different sesterterpenes including 16 undescribed compounds, possessing 10 different mono-/di-/tri-/tetra-/penta-carbocyclic skeletons, including the unique 15-membered macrocycl... |
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