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39792610 | ROS-Responsive Microneedle Patches Enable Peri-Lacrimal Gland Therapeutic Administration for Long-Acting Therapy of Sjögren's Syndrome-Related Dry Eye. | Sjögren's syndrome-related dry eye (SSDE) is a severe dry eye subtype characterized by significant immune cell attacks on the lacrimal gland. However, delivering immunosuppressive drugs to the lacrimal glands for SSDE therapy safely and sustainably poses significant challenges in clinical practice. Herein, a ROS-respon... |
39792591 | Fine-Tuning of the Sequential Self-Assembly of Entangled Polyhedra by Exploiting the Side-Chain Effect. | The control of the sequential self-assembly processes of highly entangled (Ag<sub>3</sub>L<sub>2</sub>)<sub>n</sub> (n=2,4,6,8) and Ag<sub>21</sub>L<sub>12</sub> coordination polyhedra using side-chain effects was studied via the introduction of linear or branched side chains into the tripodal ligands. In addition to c... |
39792562 | FragPT2: Multifragment Wave Function Embedding with Perturbative Interactions. | Embedding techniques allow the efficient description of correlations within localized fragments of large molecular systems while accounting for their environment at a lower level of theory. We introduce FragPT2: a novel embedding framework that addresses multiple interacting active fragments. Fragments are assigned sep... |
39792369 | <i>In Situ</i> Assembly of 3-(Tetrazol-5-yl)triazole Complexes with Ammonium Perchlorate for High-Performance Energetic Composites. | Advanced energetic composites possess promising properties and wide-ranging applications in explosives and propellants. Nonetheless, most metal-based energetic composites present significant challenges due to surface oxidation and low-pressure output. This study introduces a facile <i>in situ</i> method to develop ener... |
39792338 | Epoxy-Affixed ZIF-8/CS/Cellulase: a Sustainable Approach for Hydrolysis of Agricultural Waste to Reducing Sugars. | Cellulase was effectively immobilized onto an epoxy-bound chitosan-modified zinc metal-organic framework (epoxy/ZIF-8/CS/cellulase) support, yielding a conjugation rate of 0.64 ± 0.02 mg/cm2 and retaining 80.01 ± 0.01% of its specific activity. The bare and cellulase-bound supports was characterized by Fourier transfor... |
39792083 | Effect of Chirality and Amphiphilicity on the Antimicrobial Activity of Tripodal Lysine-Based Peptides. | A series of tripodal (three-arm) lysine-based peptides were designed and synthesized and their self-assembly properties in aqueous solution and antimicrobial activity were investigated. We compare the behaviors of homochiral tripodal peptides (KKY)<sub>3</sub>K and a homologue containing the bulky aromatic fluorenylmet... |
39792079 | Targeted NIR Fluorescent Mechanically Interlocked Molecules-Peptide Bioconjugate for Live Cancer Cells Submitochondrial Stimulated Emission Depletion Super-Resolution Microscopy. | Herein, a water-soluble, ultrabright, near-infrared (NIR) fluorescent, mechanically interlocked molecules (MIMs)-peptide bioconjugate is designed with dual targeting capabilities. Cancer cell surface overexpressed α<sub>V</sub>β<sub>3</sub> integrin targeting two RGDS tetrapeptide residues is tethered at the macrocycle... |
39792034 | Substructure-Specific Antibodies Against Fentanyl Derivatives. | Structural variants of the synthetic opioid fentanyl are a major threat to public health. Following an investigation showing that many derivatives are poorly detected by commercial lateral flow and related assays, we created hapten conjugate vaccines using an immunogenic virus-like particle carrier and eight synthetic ... |
39791925 | Ultrasensitive "On-Off" Ratiometric Fluorescence Biosensor Based on RPA-CRISPR/Cas12a for Detection of <i>Staphylococcus aureus</i>. | <i>Staphylococcus aureus</i> (<i>S. aureus</i>) is a major pathogenic bacterium responsible for bacterial foodborne diseases, making its rapid, specific, and accurate detection crucial. In this study, we develop a ratiometric biosensor based on the recombinase polymerase amplification-clustered regularly interspaced sh... |
39791864 | Flexible Site-Specific Labeling-Mediated Self-Assembly Sensor Based on Quantum Dots and LUMinescent AntiBody Sensor for Duplexed Detection of Antibodies. | Over recent years, the LUMinescent AntiBody Sensor (LUMABS) system, utilizing bioluminescence resonance energy transfer (BRET), has emerged as a highly effective method for antibody detection. This system incorporates NanoLuc (Nluc) as the donor and fluorescent protein (FP) as the acceptor. However, the limited Stokes ... |
39791372 | From Pseudocyclic to Macrocyclic Ionophores: Strategies toward the Synthesis of Cyclic Monensin Derivatives. | There has been a long search for a simple preparation of new cyclic analogues of ionophore antibiotics. We report a simple and general synthesis of three new cyclic derivatives of polyether ionophore, monensin A (MON). The application of the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes to macrocycli... |
39791306 | MOF-derived Carbon-Based Materials for Energy-Related Applications. | New carbon-based materials (CMs) are recommended as attractively active materials due to their diverse nanostructures and unique electron transport pathways, demonstrating great potential for highly efficient energy storage applications, electrocatalysis, and beyond. Among these newly reported CMs, metal-organic framew... |
39791311 | Excited-State Carrier Dynamics in Semiconducting Heterostructures from Self-Sorted NIR Active Dyes. | Heterostructures comprise two or more different semiconducting materials stacked either as co-assemblies or self-sorted based on their dynamics of aggregates. However, self-sorting in heterostructures is rather significant in improving the short exciton diffusion length and charge separation. Despite small organic mole... |
39790022 | Antioxidant, Antimicrobial, Anticancer, and Molecular Docking Insights into Pancratium maritimum Seeds and Flowers: A Phytochemical Approach. | This study investigates the antioxidant, antimicrobial, and anticancer properties of Pancratium maritimum L. in Sp. Pl.: 291 (1753) seeds and flowers. Antioxidant activity was assessed using DPPH free radical scavenging and iron chelation assays. Antimicrobial evaluations assessed the efficacy of the extracts against d... |
39790015 | Cooperative Anion-π Catalysis with Chiral Molecular Cages toward Enantioselective Desymmetrization of Anhydrides. | Exploiting novel noncovalent interactions for catalysis design represents a fascinating direction. For the flexible and relatively weak anion-π interactions, manipulation of two or more π-acidic surfaces for cooperative activation is highly desirable. Here, we demonstrate the strategy of cooperative anion-π catalysis b... |
39789208 | Cancer vaccines: platforms and current progress. | Cancer vaccines, crucial in the immunotherapeutic landscape, are bifurcated into preventive and therapeutic types, both integral to combating oncogenesis. Preventive cancer vaccines, like those against HPV and HBV, reduce the incidence of virus-associated cancers, while therapeutic cancer vaccines aim to activate dendr... |
39789155 | Sensitive and selective colorimetric detection of thiophanate-methyl based on a novel Ru-Fe<sub>3</sub>O<sub>4</sub> nanozyme with enhanced peroxidase-like activity. | A novel Ru-Fe<sub>3</sub>O<sub>4</sub> nanozyme with enhanced peroxidase-like (POD-like) activity was synthesized through a hydrothermal method. Ru-Fe<sub>3</sub>O<sub>4</sub> nanozyme was effectively utilized for the detection of thiophanate-methyl (TM) using a colorimetric technique. The POD-like activity of Ru-Fe<su... |
39788950 | Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome. | A well-balanced ion channel trafficking machinery is paramount for the normal electromechanical function of the heart. Ion channel variants and many drugs can alter the cardiac action potential and lead to arrhythmias by interfering with mechanisms like ion channel synthesis, trafficking, gating, permeation, and recycl... |
39788934 | Mitochondrial diseases: from molecular mechanisms to therapeutic advances. | Mitochondria are essential for cellular function and viability, serving as central hubs of metabolism and signaling. They possess various metabolic and quality control mechanisms crucial for maintaining normal cellular activities. Mitochondrial genetic disorders can arise from a wide range of mutations in either mitoch... |
39745191 | From Guest-Induced Crystallization to Molecular Imprinting: Calculation-Guided Discovery of Hydrogen-Bonded Tetrazole Frameworks for p-Xylene Separation. | Exploring host-guest interactions to regulate hydrogen-bonding assembly offers a promising approach for developing advanced porous crystal materials (PCMs). However, screening compatible guests with appropriate geometries and host-guest interactions that could inhibit the dense packing of building blocks remains a prim... |
39744860 | Recent Applications of Pillararene-Inspired Water-Soluble Hosts. | Pillararenes and their derivatives have emerged in supramolecular chemistry as unique macrocycles for applications in host-guest chemistry, materials science and biomimetics. Many variations have been conceived and synthesized in recent years and in this review, we relate progress in water-soluble versions: leaning tow... |
39743874 | MOF-Based Dual-Layer Pickering Emulsion: Molecular-Level Gating of Water Delivery at Water-Oil Interface for Efficient Photocatalytic Hydrogenation Using H<sub>2</sub>O as a Hydrogen Source. | Biphasic system not only presents a promising opportunity for complex catalytic processes, but also is a grand challenge in efficient tandem reactions. As an emerging solar-to-chemical conversion, the visible-light-driven and water-donating hydrogenation combines the sustainability of photocatalysis and economic-value ... |
39742452 | Direct Synthesis of Topology-Controlled BODIPY and CO<sub>2</sub>-Based Zirconium Metal-Organic Frameworks for Efficient Photocatalytic CO<sub>2</sub> Reduction. | Boron dipyrromethene (BODIPY)-based zirconium metal-organic frameworks (Zr-MOFs) possess strong light-harvesting capabilities and great potential for artificial photosynthesis without the use of sacrificial reagents. However, their direct preparation has not yet been achieved due to challenges in synthesizing suitable ... |
39727146 | Unusual Endotaxy Growth of Hexagonal Nanosheets by the Self-Assembly of a Homopolymer. | A classical crystallization usually grows epitaxially from a crystal nucleus. Presented in this study is an unusual endotaxy growth manner of a crystalline homopolymer to form hexagonal nanosheets. The amphiphilic homopolymer, poly(3-(4-(phenyldiazenyl)phenoxy)propyl methacrylate) (PAzoPMA), is first annealed in isopro... |
39714803 | Unusual Reaction of Isocyanides with Aromatic Aldehydes Catalyzed by a Supramolecular Capsule. | The supramolecular resorcinarene hexameric capsule efficiently promotes the unprecedented reaction between isocyanides and electron-deficient aromatic aldehydes leading to the formation of imines and carbon monoxide. The mechanism of the reaction was investigated via isotope labelling, kinetic analysis of the reaction,... |
39714364 | Oligoadenine Strand Functionalized Polyacrylamide Hydrogel Film Exhibiting pH-Triggered High-Degree Inverse Shape Deformations. | Smart shape-memory DNA hydrogels, which can respond to various types of external stimuli and undergo macroscopic shape deformations, have shown great potential in various applications. By constructing free-standing films, the deformation and response properties of these hydrogels can be further enhanced, and visualized... |
39670688 | Heteroatom-Based Ligand Engineering of Metal Organic Frameworks for Efficient and Robust Electrochemical Water Oxidation. | Metal-organic frameworks (MOFs) are promising catalysts for the electrochemical oxygen evolution reaction (OER) due to their high surface area, tunable pore structures, and abundant active sites. Ligand engineering is an important strategy to optimize their performance. Here, we report the synthesis of NiFe-MOFs based ... |
40487985 | Small-molecule inhibitor screen to identify mechanisms of sickle hemoglobin clearance by liver endothelium. | Intrahepatic accumulation of cell-free hemoglobin (Hb) is a significant pathology linked with hemolytic disorders such as sickle cell disease (SCD). In addition to hepatic Kupffer cells, liver sinusoidal endothelial cells (LSECs) were recently reported to contribute to Hb clearance in SCD mice and patients via currentl... |
40206603 | Wearable bioelectronics based on emerging nanomaterials for telehealth applications. | Nanomaterial-driven, soft wearable bioelectronics are transforming telemedicine by offering skin comfort, biocompatibility, and the capability for continuous remote monitoring of physiological signals. The devices, enabled by advanced zero-dimensional (0D), one-dimensional (1D), and two-dimensional (2D) nanomaterials, ... |
40171103 | Application of collagen in bone regeneration. | At present, there is a significant population of individuals experiencing bone deficiencies caused by injuries, ailments affecting the bones, congenital abnormalities, and cancer. The management of substantial bone defects a significant global orthopedic challenge due to the intricacies involved in promoting and restor... |
39925527 | COVID-19 Humic/Fulvic Acid Plus Epigallocatechin Gallate Treatment: A Retrospective Chart Review. | <h4>Introduction</h4>The initial COVID-19 infection caused significant mortality in the nursing home setting. The mortality in our facility was approximately 50% and occurred in the later phase of the initial infection. In the nursing home setting, there were no approved treatment regimes. Specific treatment was left t... |
39914952 | Chitosan cryogels incorporated with phytic acid-modified UiO-66-NH<sub>2</sub> for enhanced flame-retardant performance. | In this work, chitosan (CS) was used as the skeleton to synthesize flame-retardant composite cryogels. Phytic acid (PA)-modified Zr-based metal-organic framework (PA-UiO-66-NH<sub>2</sub>) was integrated into the CS network to enhance flame retardant performance. The vertical combustion test (UL-94) grade was V-0, and ... |
39914947 | Current advances in the synthesis of beta-cyclodextrin-based metal organic frameworks and their potential applications in the adsorption/removal of pollutants: A comprehensive review. | Beta-cyclodextrin-based metal-organic frameworks (βCD-MOFs) are porous coordination compounds that represent a versatile class of renewable, biocompatible, edible, and non-toxic MOFs. These structures can be produced on a large scale by linking organic bridging ligands and metal ions. βCD-MOFs have increasingly attract... |
39886575 | Hydroxyl Radical-π Interaction in a Single Crystal. | Numerous attempts for organic radical stability mostly entail steric hindrance, spin-delocalization, supramolecular interaction with the host, π-π interactions, and hydrogen bonding. To date, there is no report of single crystals containing a hydroxyl radical (<sup>•</sup>OH). In this work, we have stabilized <sup>•</s... |
39886029 | Neptunium Pyridine Dipyrrolide Complexes. | Two pyridine dipyrrolide neptunium(IV) complexes, (<sup>Mes</sup>PDP<sup>Ph</sup>)NpCl<sub>2</sub>(THF) and Np(<sup>Mes</sup>PDP<sup>Ph</sup>)<sub>2</sub>, where (<sup>Mes</sup>PDP<sup>Ph</sup>)<sup>2-</sup> is the doubly deprotonated form of 2,6-bis(5-(2,4,6-trimethylphenyl)-3-phenyl-1<i>H</i>-pyrrol-2-yl)pyridine, ha... |
39877425 | Plasmonic Nanoparticles for Photothermal Therapy: Benchmarking of Photothermal Properties and Modeling of Heating at Depth in Human Tissues. | Many different types of nanoparticles have been developed for photothermal therapy (PTT), but directly comparing their efficacy as heaters and determining how they will perform when localized at depth in tissue remains complex. To choose the optimal nanoparticle for a desired hyperthermic therapy, it is vital to unders... |
39861729 | Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery. | Cyclodextrins can serve as carriers for various payloads, utilizing their capacity to form unique host-guest inclusion complexes within their cavity and their versatile surface functionalization. Recently, cationic cyclodextrins have gained considerable attention, as they can improve drug permeability across negatively... |
39861727 | Selection of In Vivo Relevant Dissolution Test Parameters for the Development of Cannabidiol Formulations with Enhanced Oral Bioavailability. | <b>Background:</b> Cannabidiol (CBD) shows interesting therapeutic properties but has yet to demonstrate its full potential in clinical trials partly due to its low solubility in physiologic media. Two different formulations of CBD (amorphous and lipid-based) have been optimized and enable an increase in bioavailabilit... |
39861525 | Variations in the End-Use Quality of Whole Grain Flour Are Closely Related to the Metabolites in the Grains of Pigmented Wheat (<i>Triticum aestivum</i> L.). | Whole grain flour is considered a part of a healthy diet, especially when produced with pigmented wheat (<i>Triticum aestivum</i>). However, the specific metabolic pathways and mechanisms by which these metabolites affect the end-use quality of pigmented wheat varieties still need to be better understood. This study ex... |
39861227 | Ultrasonic Deposition of Cellulose Nanocrystals on Substrates for Enhanced Eradication Activity on Multidrug-Resistant Pathogens. | Amidst the pervasive threat of bacterial afflictions, the imperative for advanced antibiofilm surfaces with robust antimicrobial efficacy looms large. This study unveils a sophisticated ultrasonic synthesis method for cellulose nanocrystals (CNCs, 10-20 nm in diameter and 300-900 nm in length) and their subsequent appl... |
39861133 | Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis. | <i>Mycobacterium tuberculosis</i> infections continue to pose a significant global health challenge, particularly due to the rise of multidrug-resistant strains, random mycobacterial mutations, and the complications associated with short-term antibiotic regimens. Currently, five approved drugs target cell wall biosynth... |
39861135 | From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents. | Ciprofloxacin, a widely used second-generation fluoroquinolone for treating bacterial infections, has recently shown notable anticancer properties. This review explores progress in developing ciprofloxacin derivatives with anticancer properties, emphasizing key structural changes that improve their therapeutic effectiv... |
39861011 | Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis. | Cytomegalovirus (CMV) is a ubiquitous virus that infects most of the human population and causes significant morbidity and mortality, particularly among immunocompromised individuals. Understanding CMV's genetic diversity and evolutionary dynamics is crucial for elucidating its pathogenesis and developing effective the... |
39860394 | A Real-World Comparison of the Safety Profile for Immune Checkpoint Inhibitors in Oncology Patients. | <b>Background/Objectives:</b> Owing to the growing use of immune checkpoint inhibitors (ICIs) in the treatment of cancer, a wide spectrum of toxicity has arisen among cancer patients. Yet, limited ICI toxicity-related research is currently conducted in our region. <b>Methods:</b> This is a retrospective observational s... |
39860113 | Discovery of Quinazolone Pyridiniums as Potential Broad-Spectrum Antibacterial Agents. | The overprescription of antibiotics in medicine and agriculture has accelerated the development and spread of antibiotic resistance in bacteria, which severely limits the arsenal available to clinicians for treating bacterial infections. This work discovered a new class of heteroarylcyanovinyl quinazolones and quinazol... |
39860111 | Molecular Origami: Designing Functional Molecules of the Future. | In the field of chemical biology, DNA origami has been actively researched. This technique, which involves folding DNA strands like origami to assemble them into desired shapes, has made it possible to create complex nanometer-sized structures, marking a major breakthrough in nanotechnology. On the other hand, controll... |
39860101 | Encapsulation of Vecuronium and Rocuronium by Sugammadex Investigated by Surface-Enhanced Raman Spectroscopy. | Aiming toward a novel, noninvasive technique, with a real-time potential application in the monitoring of the complexation of steroidal neuromuscular blocker drugs Vecuronium (<b>Vec</b>) and Rocuronium (<b>Roc</b>) with sugammadex (<b>SDX</b>, medication for the reversal of neuromuscular blockade induced by <b>Vec</b>... |
39860102 | Enhanced Antibacterial Activity of Hydrophobic Modified Lysozyme Against Gram-Negative Bacteria Without Accumulated Resistance. | Macromolecule bactericides present challenges such as low biocompatibility and not being biodegradable, so broad-spectrum bactericides without accumulated bacteria resistance are now in urgent demand all over the world. Lysozyme, a kind of wide-spread natural enzyme easily extracted from nature, has become attractive f... |
39859729 | Magnetite Nanoparticles Encapsulated with PBS-PEG for AMF Hyperthermia. | Novel studies on typical synthesized magnetite nanoparticles were encapsulated into a poly (butylene succinate)/poly (ethylene glycol) copolymer (PBS-PEG). PBS was chosen because of its biocompatibility characteristics necessary for biomedical applications. PEG, as part of the macromolecular structure, increases the hy... |
39859229 | Luminescence Properties of Hoechst 33258 in Polyvinyl Alcohol Films. | We report a comprehensive investigation of the photophysical properties of Hoechst 33258 (HOE) embedded in polyvinyl alcohol (PVA) films. HOE displays a bright, highly polarized, blue fluorescence emission centered at 430 nm, indicating effective immobilization within the polymer matrix of PVA. Its fluorescence quantum... |
39859209 | Molecular Characterization of Cancer Preventive and Therapeutic Potential of Three Antistress Compounds, Triethylene Glycol, Withanone, and Withaferin A. | The molecular link between stress and carcinogenesis and the positive outcomes of stress intervention in cancer therapy have recently been well documented. Cancer stem cells (CSCs) facilitate cancer malignancy, drug resistance, and relapse and, hence, have emerged as a new therapeutic target. Here, we aimed to investig... |
39858482 | Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review. | One class of cosmetic compounds that have raised interest of many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use of peptides in cosmetic products. Peptides are novel active ingredients that improve collagen synthesis, enhance skin cell proliferation, or dec... |
39858349 | Unseen Enemy: Mechanisms of Multidrug Antimicrobial Resistance in Gram-Negative ESKAPE Pathogens. | Multidrug antimicrobial resistance (AMR) represents a formidable challenge in the therapy of infectious diseases, triggered by the particularly concerning gram-negative <i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>,... |
39858149 | Swine Acute Diarrhea Syndrome Coronavirus: An Overview of Virus Structure and Virus-Host Interactions. | SADS-CoV, a recently identified <i>Rhinolophus</i> bat coronavirus HKU2-associated swine coronavirus, is a malignant pathogen that causes acute diarrhea, severe diarrhea, and weight loss in infected piglets. The virus was first detected in Guangdong Province, China, in 2017 and has since been observed in Jiangxi, Fujia... |
39856853 | Characterization and Comparison of Structure and Physicochemical Properties of Highland Barley Starch of Different Colors. | Domesticated highland barley is an important starch reserve and has differently colored grains, owing to different genotype backgrounds and cultivation environments. In this study, black, purple, blue, and yellow highland barley varieties were planted under the same cultivation conditions, and their starch distribution... |
39852830 | Peptide Antigen Modifications Influence the On-Target and Off-Target Antibody Response for an Influenza Subunit Vaccine. | <h4>Background/objectives</h4>Peptide amphiphile micelles (PAMs) are an exciting nanotechnology currently being studied for a variety of biomedical applications, especially for drug delivery. Specifically, PAMs can enhance in vivo trafficking, cell-targeting, and cell interactions/internalization. However, modifying pe... |
39852705 | Various Sizes and Shapes of Mixed-Anion Fe(NH<sub>2</sub>trz)<sub>3</sub>(BF<sub>4</sub>)<sub>2-x</sub>(SiF<sub>6</sub>)<sub>x/2</sub>@SiO<sub>2</sub> Nanohybrid Particles Undergoing Spin Crossover Just Above Room Temperature. | Spin crossover (SCO) iron (II) coordination compounds in the form of nanohybrid SCO@SiO<sub>2</sub> particles were prepared using a reverse micelles technique based on the TritonX-100/cyclohexane/water ternary system. Tetraethyl orthosilicate (TEOS) acts as precursor of both the SiF<sub>6</sub><sup>2-</sup> counter-ani... |
39852260 | ZIF-8-Embedded Cation-Exchange Membranes with Improved Monovalent Ion Selectivity for Capacitive Deionization. | Membrane capacitive deionization (MCDI) is an electrochemical ion separation process that combines ion-exchange membranes (IEMs) with porous carbon electrodes to enhance desalination efficiency and address the limitations of conventional capacitive deionization (CDI). In this study, a cation-exchange membrane (CEM) emb... |
39852258 | A Review of Sulfate Removal from Water Using Polymeric Membranes. | Access to clean and reliable water has become a critical concern due to the global water crisis. High sulfate levels in drinking water raise health concerns for humans and animals and can cause serious corrosion in industrial systems. Sulfated waters represent a major challenge on the Canadian prairies, leading to many... |
39852086 | Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications-A Comprehensive Review. | Surface Plasmon Resonance (SPR)-based biodetection systems have emerged as powerful tools for real-time, label-free biomolecular interaction analysis, revolutionizing fields such as diagnostics, drug discovery, and environmental monitoring. This review highlights the foundational principles of SPR, focusing on the inte... |
39850902 | Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection. | CASK, a MAGUK family scaffold protein, regulates gene expression as a transcription co-activator in neurons. However, the mechanism of CASK nucleus translocation and the regulatory function of CASK in myeloid cells remains unclear. Here, we investigated its role in H5N1-infected macrophages. We found that H5N1 triggers... |
39850874 | Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy. | Molecular characterization of tumors is essential to identify predictive biomarkers that inform treatment decisions and improve precision immunotherapy development and administration. However, challenges such as the heterogeneity of tumors and patient responses, limited efficacy of current biomarkers, and the predomina... |
39850757 | Recent advances of lysine lactylation in prokaryotes and eukaryotes. | Lysine lactylation is a newly discovered protein post-translational modification that plays regulatory roles in cell metabolism, growth, reprogramming, and tumor progression. It utilizes lactate as the modification precursor, which is an end product of glycolysis while functioning as a signaling molecule in cells. Unli... |
39850587 | Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration. | Fertility rates are declining in livestock such as cattle, and more than one in five Japanese couples have undergone infertility treatment or are currently infertile. Improving the fertilization rates of domesticated animals is imperative for improving their productivity and maintaining valuable lineages. In this study... |
39850571 | Association of early aspirin use with 90-day mortality in patients with sepsis: an PSM analysis of the MIMIC-IV database. | <h4>Objective</h4>In addition to its antiplatelet and anti-inflammatory properties, aspirin inhibits bacterial proliferation directly. The potential benefits of aspirin may enhance the prognosis for sepsis patients. However, little is known about the effects of early aspirin administration. This study aimed to examine ... |
39850218 | Effect of operational parameters on droplet deposition characteristics using an unmanned aerial vehicle for banana canopy. | In recent years, as an important part of precision agricultural aviation, the plant protection unmanned aerial vehicle (UAV) has been widely studied and applied worldwide, especially in East Asia. Banana, as a typical large broad-leaved crop, has high requirements for pests and diseases control. The mechanization degre... |
39850207 | Comparative response mechanisms of two cultivars of <i>Musa paradisiaca L.</i> to <i>Fusarium oxysporum</i> f.sp. <i>cubense</i> infection. | With the aim of enhancing plants' ability to respond to pathogenic fungi, this study focuses on disease resistance genes. We commenced a series of investigations by capitalizing on the pronounced differences in resistance to Fusarium wilt between resistant and susceptible varieties. Through an in-depth exploration of t... |
39850133 | Characterization and pathogenicity of a novel avian orthoreovirus in China. | <h4>Introduction</h4>Avian orthoreovirus (ARV) is a significant pathogen causing viral arthritis, leading to substantial economic losses in the poultry industry worldwide.<h4>Methods</h4>A novel ARV strain, designated FJ202311, was isolated from a broiler farm in Fujian Province, China. Whole-genome sequencing was cond... |
39850130 | Unveiling the nanoworld of antimicrobial resistance: integrating nature and nanotechnology. | A significant global health crisis is predicted to emerge due to antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic resistance necessitates continuous therapeutic innovation as conventional antibiotic treatments become increasingly ineffective. The naturally occurring ... |
39846707 | Treatment of Onychomycosis and the Drug-Drug Interactions in Patients with Diabetes Mellitus and Diabetic Foot Syndrome: A Systematic Review. | <b>Background:</b> This systematic review reports on treatments for onychomycosis in patients with diabetes and the drug interactions with other drugs in regard to the complicated diabetic patient profile. <b>Methods:</b> The recommendations in the preferred reporting items for systematic reviews and meta-analysis (PRI... |
39846613 | Targeting CD44 and EpCAM with Antibody Dye Conjugates for the Photoimmunotherapy of Prostate Cancer. | <h4>Background/objectives</h4>Photoimmunotherapy (PIT) is an innovative approach for the targeted therapy of cancer. In PIT, photosensitizer dyes are conjugated to tumor-specific antibodies for targeted delivery into cancer cells. Upon irradiation with visible light, the photosensitizer dye is activated and induces can... |
39840296 | Fluorinated and methylated <i>ortho</i>-benzodipyrrole-based acceptors suppressing charge recombination and minimizing energy loss in organic photovoltaics. | The elimination of the A' unit from -type Y6-derivatives has led to the development of a new class of <i>ortho</i>-benzodipyrrole (<i>o</i>-BDP)-based A-D<sub>N</sub>B<sub>N</sub>D-A-type NFAs. In this work, two new A-D<sub>N</sub>B<sub>N</sub>D-A-type NFAs, denoted as CFB and CMB, are designed and synthesized, where e... |
39829977 | Self-sensitized Cu(ii)-complex catalyzed solar driven CO<sub>2</sub> reduction. | Developing a self-sensitized catalyst from earth-abundant elements, capable of efficient light harvesting and electron transfer, is crucial for enhancing the efficacy of CO<sub>2</sub> transformation, a critical step in environmental cleanup and advancing clean energy prospects. Traditional approaches relying on extern... |
39824052 | Excellent acetone sensing enabled by tunable metal organic framework derived TiO<sub>2</sub> nanodisks. | Annealing plays a crucial role for in enhancing the gas sensing properties of MOF-derived TiO<sub>2</sub> (MIL-125). Generally, TiO<sub>2</sub> transforms into different polymorphs (anatase, rutile, and brookite) during annealing, each with unique crystal structures and gas sensing properties. The aim of this research ... |
39818011 | Synthesis and biological assessment of BUB1B inhibitors for the treatment of clear cell renal cell carcinoma. | Clear cell renal cell carcinoma (ccRCC) presents substantial therapeutic challenges due to its molecular heterogeneity, limited response to conventional therapies, and widespread drug resistance. Recent advancements in molecular research have identified novel targets, such as BUB1B, which has been identified through gl... |
39816474 | Convergent-beam attosecond x-ray crystallography. | Sub-ångström spatial resolution of electron density coupled with sub-femtosecond to few-femtosecond temporal resolution is required to directly observe the dynamics of the electronic structure of a molecule after photoinitiation or some other ultrafast perturbation, such as by soft X-rays. Meeting this challenge, pushi... |
39816377 | Phytosomes Loaded with Mastoparan-M Represent a Novel Strategy for Breast Cancer Treatment. | <h4>Purpose</h4>Mastoparan-M (Mast-M) has cytotoxic effects on various tumor cells in vitro, including liver cancer and colorectal cancer. However, the anti-tumor mechanism of Mast-M remains unclear and its potential for anti-tumor therapy has not been investigated. Herein, we aimed to develop a novel phytosome formula... |
39816376 | Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration. | Poor aqueous solubility and bioavailability limit the translation of new drug candidates into clinical applications. Nanocrystal formulations offer a promising approach for improving the dissolution rate and saturation solubility. These formulations are applicable for various routes of administration, with each present... |
39811244 | A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery. | Disruption of cholinesterases and, as a consequence, increased levels of acetylcholine lead to serious disturbances in the functioning of the nervous system, including death. The need for rapid administration of an antidote to restore esterase activity is critical, but practical implementation of this is often difficul... |
39808983 | Enhanced bioaccessibility of cyclolinopeptides via zein-cyclodextrin nanoparticles: Simulated gastrointestinal digestion and cellular uptake study. | Cyclolinopeptides (CLS) are hydrophobic cyclic peptides in flaxseed with multiple bioactive activities. This study developed zein (Z)-cyclodextrin (CD) binary nanoparticles (NPs) as an oral delivery system for CLS. Z-CD NP had a smaller diameter (D<sub>h</sub>) and better encapsulation effect on CLS. Formation of CLS-l... |
39808980 | A novel fluorescent sensor for highly sensitive detection of ascorbic acid in food based on inhibiting phosphatase-like activity of Zr-based MOF. | Nanozyme-based sensors for detecting ascorbic acid (AA) generally depend on the reducibility of the analyte. However, these sensors are susceptible to interference from reducing substances in food. Herein, a novel fluorescent sensor for AA detection was developed based on inhibiting the phosphatase-like activity of a Z... |
39802698 | Evolution of amorphous ruthenium nanoclusters into stepped truncated nano-pyramids on graphitic surfaces boosts hydrogen production from ammonia. | Atomic-scale changes can significantly impact heterogeneous catalysis, yet their atomic mechanisms are challenging to establish using conventional analysis methods. By using identical location scanning transmission electron microscopy (IL-STEM), which provides quantitative information at the single-particle level, we i... |
39802479 | Research progress on and outlook of direct CO<sub>2</sub> thickeners for enhanced oil recovery. | Supercritical CO<sub>2</sub>, as an environmentally friendly and pollution-free fluid, has been applied in various EOR techniques such as CO<sub>2</sub> flooding. However, the low viscosity of the gas leads to issues such as early breakthrough, viscous fingering, and gravity override in practical applications. Although... |
39799885 | A signal amplifying MOF-based probe:on-site and ultrasensitive dual-channel portable detection of Hg<sup>2+</sup> in groundwater through a fluorimetrically and RGB-based sensing assay. | Mercury (II) ions (Hg<sup>2+</sup>) are a significant source of heavy metal contamination in groundwater, posing a serious threat to human health and the environment. Therefore, there is an urgent need for the development of a new detection technique with high sensitivity for monitoring Hg<sup>2+</sup> in contaminated ... |
39798740 | Polysaccharide-based drug delivery targeted approach for colon cancer treatment: A comprehensive review. | Colon cancer is a leading cause of cancer-related morbidity and mortality worldwide, necessitating advancements in therapeutic strategies to improve outcomes. Current treatment modalities, including surgery, chemotherapy, and radiation, are limited by systemic toxicity, low drug utilization rates, and off-target effect... |
39798635 | Interpenetrating networks of fibrillar and amorphous collagen promote cell spreading and hydrogel stability. | Hydrogels composed of collagen, the most abundant protein in the human body, are widely used as scaffolds for tissue engineering due to their ability to support cellular activity. However, collagen hydrogels with encapsulated cells often experience bulk contraction due to cell-generated forces, and conventional strateg... |
39794220 | Guidance on biomaterials for periodontal tissue regeneration: Fabrication methods, materials and biological considerations. | Regeneration of the multiple tissues and interfaces in the periodontal complex necessitates multidisciplinary evaluation to establish structure/function relationships. This article, an initiative of the Academy of Dental Materials, provides guidance for performing chemical, structural, and mechanical characterization o... |
39793961 | LTX-315 is a novel broad-spectrum antimicrobial peptide against clinical multidrug-resistant bacteria. | <h4>Introduction</h4>Infections stemming from multidrug-resistant bacteria present a substantial threat to public health today. Discovering or synthesizing novel compounds is crucial to alleviate this pressing situation.<h4>Objective</h4>The main purpose of this study is to verify the antibacterial activity of LTX-315 ... |
39793913 | Improved synthesis and characterization of bile acid esters: Organogelation and supramolecular properties. | Bile acid esters and their derivatives hold significant interest due to their applications in fields such as supramolecular chemistry, biomedicine, and nanomaterials. This study revisits the synthesis and characterization of esters derived from cholic, deoxycholic, and lithocholic acids using short-chain alcohols in co... |
39793822 | Novel Co-MOF-doped gelatin/agar intelligent film for beef freshness visual tracking based on the structural change of ZIF-67 under ammonia etching effect. | It is an important task to construct intelligent packaging for meat freshness monitoring with good color stability and indication function. Herein, cobalt-based metal-organic framework nanomaterials (Co-MOF, ZIF-67) with antimicrobial and ammonia-sensitive properties were successfully synthesized and added into gelatin... |
39790178 | Mechanistic insight into human milk extracellular vesicle-intestinal barrier interactions. | Human milk extracellular vesicles (EVs) are crucial mother-to-baby messengers that transfer biological signals. These EVs are reported to survive digestion and transport across the intestine. The mechanisms of interaction between human milk EVs and the intestinal mucosa, including epithelial uptake remain unclear. Here... |
39789913 | Flexible Morphological Regulation of Photothermal Nanodrugs: Understanding the Relationship between the Structure, Photothermal Effect, and Tumoral Biodistribution. | The morphology of nanodrugs is of utmost importance in photothermal therapy because it directly influences their physicochemical behavior and biological responses. However, clarifying the inherent relationship between morphology and the resultant properties remains challenging, mainly due to the limitations in the flex... |
39789889 | Zebrafish as a Visible Neuroinflammation Model for Evaluating the Anti-Inflammation Effect of Curcumin-Loaded Ferritin Nanoparticles. | It is crucial to inhibit the neuroinflammation response as it is a prominent factor contributing to the pathogenesis of neurodegenerative disorders. However, the limited development of neuroinflammation models dramatically hinders the efficiency of nanomedicine discovery. In recent years, the optically transparent zebr... |
39789765 | Control of Permanent Porosity in Type 3 Porous Liquids via Solvent Clustering. | Porous liquids (PLs) are an exciting new class of materials for carbon capture due to their high gas adsorption capacity and ease of industrial implementation. They are composed of sorbent particles suspended in a nonadsorbed solvent, forming a liquid with permanent porosity. While PLs have a vast number of potential c... |
39789725 | A High-Throughput Screening Pipeline to Identify Methyltransferase and Exonuclease Inhibitors of SARS-CoV-2 NSP14. | SARS-CoV-2 infections led to a worldwide pandemic in 2020. As of 2024, therapeutics against SARS-CoV-2 have continued to be desirable. NSP14 is a dual-function methyltransferase (MTase) and exonuclease (ExoN) with key roles in SARS-CoV-2 genome propagation and host immune system evasion. In this work, we developed high... |
39789492 | High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy. | <h4>Background</h4>Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder associated with pregnancy and is usually diagnosed based on high serum bile acid. However, the pathogenesis of ICP is unclear. Ferroptosis has been reported as an iron-dependent mechanism of cell death. Although the role of... |
39789481 | Exploring the potential of gemcitabine-metal-organic frameworks in combating pancreatic cancer under ketogenic conditions. | <h4>Background</h4>Inadequate treatment responses, chemotherapy resistance, significant heterogeneity, and lengthy treatment durations create an urgent need for new pancreatic cancer therapies. This study aims to investigate the effectiveness of gemcitabine-loaded nanoparticles enclosed in an organo-metallic framework ... |
39789330 | Real-time visualisation of fast nanoscale processes during liquid reagent mixing by liquid cell transmission electron microscopy. | Liquid cell transmission electron microscopy (LCTEM) is a powerful technique for investigating crystallisation dynamics with nanometre spatial resolution. However, probing phenomena occurring in liquids while mixing two precursor solutions has proven extremely challenging, requiring sophisticated liquid cell designs. H... |
39789307 | Advancing brain immunotherapy through functional nanomaterials. | Glioblastoma (GBM), a highly aggressive brain tumor, poses significant treatment challenges due to its highly immunosuppressive microenvironment and the brain immune privilege. Immunotherapy activating the immune system and T lymphocyte infiltration holds great promise against GBM. However, the brain's low immunogenici... |
39789017 | Charge-transfer complexation of coordination cages for enhanced photochromism and photocatalysis. | Intensified host-guest electronic interplay within stable metal-organic cages (MOCs) presents great opportunities for applications in stimuli response and photocatalysis. Zr-MOCs represent a type of robust discrete hosts for such a design, but their host-guest chemistry in solution is hampered by the limited solubility... |
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