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39789014 | Underscoring long-term host-microbiome interactions in a physiologically relevant gingival tissue model. | The human body houses many distinct and interconnecting microbial populations with long-lasting systemic effects, where the oral cavity serves as a pathogens' reservoir. The correlation of different disease states strongly supports the need to understand the interplay between the oral tissue niche and microbiome. Despi... |
39788944 | Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection. | Influenza remains a persistent global health challenge, largely due to the virus' continuous antigenic drift and occasional shift, which impede the development of a universal vaccine. To address this, the identification of broadly neutralizing antibodies and their epitopes is crucial. Nanobodies, with their unique char... |
39788940 | Microfluidic platforms for monitoring cardiomyocyte electromechanical activity. | Cardiovascular diseases account for ~40% of global deaths annually. This situation has revealed the urgent need for the investigation and development of corresponding drugs for pathogenesis due to the complexity of research methods and detection techniques. An in vitro cardiomyocyte model is commonly used for cardiac d... |
39788937 | Near-infrared fluorogenic RNA for in vivo imaging and sensing. | Fluorogenic RNA aptamers have various applications, including use as fluorescent tags for imaging RNA trafficking and as indicators of RNA-based sensors that exhibit fluorescence upon binding small-molecule fluorophores in living cells. Current fluorogenic RNA:fluorophore complexes typically emit visible fluorescence. ... |
39788927 | DNA Aptamer-Polymer Conjugates for Selective Targeting of Integrin α4β1<sup>+</sup> T-Lineage Cancers. | Selective therapeutic targeting of T-cell malignancies is difficult due to the shared lineage between healthy and malignant T cells. Current front-line chemotherapy for these cancers is largely nonspecific, resulting in frequent cases of relapsed/refractory disease. The development of targeting approaches for effective... |
39788894 | Cu-Catalyzed Relay Functionalization of Alkenes: Diverse Synthesis of Diazidated Quinazolinones and Polycyclic Imidazoles. | A Cu-catalyzed relay process for the preparation of diazidated quinazolinone and polycyclic imidazole derivatives in which readily available alkene-tethered substrates undergo an addition/cyclization/C(sp<sup>3</sup>)-H functionalization of alkene sequences with high efficiency is described. Various functionalized N-he... |
39788886 | Dendrimer-Mediated Generation of a Metal-Phenolic Network for Antibody Delivery to Elicit Improved Tumor Chemo/Chemodynamic/Immune Therapy. | To simplify the composition and improve the efficacy of metal-phenolic network (MPN)-based nanomedicine, herein, we designed an MPN platform to deliver programmed death ligand-1 (PD-L1) antibody (anti-PD-L1) for combined tumor chemo/chemodynamic/immune therapy. Here, generation 5 poly(amidoamine) dendrimers conjugated ... |
39787294 | Dynamic Peptide Nanoframework-Guided Protein Coassembly: Advancing Adhesion Performance with Hierarchical Structures. | Hierarchical structures are essential in natural adhesion systems. Replicating these in synthetic adhesives is challenging due to intricate molecular mechanisms and multiscale processes. Here, we report three phosphorylated peptides featuring a hydrophobic self-assembly motif linked to a hydrophilic phosphorylated sequ... |
39787272 | Catalytic Assembly of Peptides Mediated by Complex Coacervates. | The assembly of peptides is generally mediated by liquid-liquid phase separation, which enables control over assembly kinetics, final structure, and functions of peptide-based supramolecular materials. Modulating phase separation can alter the assembly kinetics of peptides by changing solvents or introducing external f... |
39787197 | Top-Down versus Bottom-Up Approaches for σ-Functionals Based on the Approximate Exchange Kernel. | Recently, we investigated a number of so-called σ- and τ-functionals based on the adiabatic-connection fluctuation-dissipation theorem (ACFDT); particularly, extensions of the random phase approximation (RPA) with inclusion of an exchange kernel in the form of an antisymmetrized Hartree kernel. One of these functionals... |
39787004 | The Effects of Morphology and Hydration on Anion Transport in Self-Assembled Nanoporous Membranes. | Ordered nanoporous polymer membranes offer opportunities for systematically probing the mechanisms of ion transport under confinement and for realizing useful materials for electrochemical devices. Here, we examine the impact of morphology and ion hydration on the transport of hydroxide and bromide anions in nanostruct... |
39786932 | Partial PdAu nanoparticle embedding into TiO<sub>2</sub> support accentuates catalytic contributions from the Au/TiO<sub>2</sub> interface. | Despite the broad catalytic relevance of metal-support interfaces, controlling their chemical nature, the interfacial contact perimeter (exposed to reactants), and consequently, their contributions to overall catalytic reactivity, remains challenging, as the nanoparticle and support characteristics are interdependent w... |
39786690 | Screening for cardiac sarcoidosis: diagnostic approach and long-term follow-up in a tertiary centre. | <h4>Background</h4>Cardiac sarcoidosis (CS) is associated with poor prognosis, making early diagnosis and treatment important. This study evaluated the results of a diagnostic approach in patients with known sarcoidosis and suspected cardiac involvement in a tertiary centre and their long-term outcomes.<h4>Methods</h4>... |
39786666 | Emerging trends in long-acting sustained drug delivery for glaucoma management. | Glaucoma is an optic neuropathy in which progressive degeneration of retinal ganglion cells and the optic nerve leads to irreversible visual loss. Glaucoma is one of the leading causes of blindness. The pathogenesis of glaucoma is determined by different pathogenetic mechanisms, including increased intraocular pressure... |
39786667 | A SERS and colorimetric dual-mode biosensor based on stimulus-responsive DNA/MOF-bound bimetallic nanozyme for the ultrasensitive detection of chloramphenicol in food. | A dual-mode detection platform utilizing colorimetric and Raman was developed based on the exponential amplification reaction (EXPAR) strategy and a "core-satellite" structure constructed by bimetallic nanozymes to detect chloramphenicol (CAP). Initially, DNA-gated metal-organic frameworks (MOFs) incorporating cascaded... |
39786561 | The influence of prolonged aerobic exercise on cardiac, muscular, and renal biomarkers in trained individuals with obesity. | <h4>Purpose</h4>The aim of this study was to investigate the influence of prolonged aerobic exercise on cardiac, muscular and renal inflammatory markers in a group of trained obese men.<h4>Methods</h4>Seventeen men (aged 40 ± 6 years; body mass index [BMI] 31.3 ± 2.8 kg m<sup>-2</sup>, maximal oxygen uptake [V'O<sub>2<... |
39786338 | α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure. | Epithelial cells can become polyploid upon tissue injury, but mechanosensitive cues that trigger this state are poorly understood. Using an Madin Darby Canine Kidney (MDCK) cell knock-out/reconstitution system, we show that α-catenin mutants that alter force-sensitive binding to F-actin or middle (M)-domain promote cyt... |
39785585 | Solvent-Driven Self-Assembly of Discrete Ni(II)-Azide Complexes: Unraveling Unusual Behavior in Mimicking Jack Bean Urease. | The well-known inhibitory strength of 3d metal Schiff base complexes against urease enzymes has long been acknowledged, but their untapped potential to act as ureolytic mimics of active metallobiosites remained unexplored. To break the new ground, we present pyrrolidine-based mononuclear Ni(II)-azide complex <b>1</b> {... |
39785238 | Rational Modification of a Cross-Linker for Improved Flexible Protein Structure Modeling. | Chemical cross-linking/mass spectrometry (XL-MS) has emerged as a complementary tool for mapping interaction sites within protein networks as well as gaining moderate-resolution native structural insight with minimal interference. XL-MS technology mostly relies on chemoselective reactions (cross-linking) between protei... |
39783932 | Effective Gene Expression Prediction and Optimization from Protein Sequences. | High soluble protein expression in heterologous hosts is crucial for various research and applications. Despite considerable research on the impact of codon usage on expression levels, the relationship between protein sequence and expression is often overlooked. In this study, a novel connection between protein express... |
39783908 | Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides. | Sigal peptides have garnered remarkable efficacy in rejuvenating photoaged skin and delaying senescence. Nevertheless, their low solubility and poor permeability bring about a formidable challenge in their transdermal delivery. To address this challenge, bioactive ionic liquids (ILs) synthesized from natural glycyrrhiz... |
39783835 | Structural Design and Challenges of Micron-Scale Silicon-Based Lithium-ion Batteries. | Currently, lithium-ion batteries (LIBs) are at the forefront of energy storage technologies. Silicon-based anodes, with their high capacity and low cost, present a promising alternative to traditional graphite anodes in LIBs, offering the potential for substantial improvements in energy density. However, the significan... |
39783825 | Plug-In Design of the Microneedle Electrode Array for Multi-Parameter Biochemical Sensing in Gouty Arthritis. | Gouty arthritis is one of the most common forms of inflammatory arthritis and has brought a significant burden on patients and society. Current strategies for managing gout primarily focus on long-term urate-lowering therapy. With the rapid advancement of point-of-care testing (POCT) technology, continuous monitoring o... |
39783798 | Breaking the Trade-Off Between Electrical Conductivity and Mechanical Strength in Bulk Graphite Using Metal-Organic Framework-Derived Precursors. | High-performance bulk graphite (HPBG) that simultaneously integrates superior electrical conductivity and excellent strength is in high demand, yet it remains critical and challenging. Herein a novel approach is introduced utilizing MOF-derived nanoporous metal/carbon composites as precursors to circumvent this traditi... |
39783796 | Injectable Senolytic Hydrogel Depot for the Clearance of Senescent Cells. | Small molecules are frontline therapeutics for many diseases; however, they are often limited by their poor solubility. Therefore, hydrophobic small molecules are often encapsulated or prepared as pure drug nanoparticles. Navitoclax, used to eliminate senescent cells, is one such small molecule that faces challenges in... |
39783786 | Single-Cell Multi-omics Assessment of Spinal Cord Injury Blocking via Cerium-doped Upconversion Antioxidant Nanoenzymes. | Spinal cord injury (SCI) impairs the central nervous system and induces the myelin-sheath-deterioration because of reactive oxygen species (ROS), further hindering the recovery of function. Herein, the simultaneously emergency treatment and dynamic luminescence severity assessment (SETLSA) strategy is designed for SCI ... |
39783715 | Lattice Oxygen Redox Dynamics in Zeolite-Encapsulated CsPbBr<sub>3</sub> Perovskite OER Electrocatalysts. | Understanding the oxygen evolution reaction (OER) mechanism is pivotal for improving the overall efficiency of water electrolysis. Despite methylammonium lead halide perovskites (MAPbX<sub>3</sub>) have shown promising OER performance due to their soft-lattice nature that allows lattice-oxygen oxidation of active α-PbO... |
39783156 | Multifaceted Catalytic Glucose Depletion and Reactive Oxygen Species-Scavenging Nanoenzyme Composite Hydrogel for Facilitating Diabetic Bone Regeneration. | Regeneration of diabetic bone defects remains a formidable challenge due to the chronic hyperglycemic state, which triggers the accumulation of advanced glycation end products (AGEs) and reactive oxygen species (ROS). To address this issue, we have engineered a bimetallic metal-organic framework-derived Mn@Co<sub>3</su... |
39783139 | Polymer-Grafted Gold Colloids and Supracolloids: From Mechanisms of Formation to Dynamic Soft Matter. | Gold nanoparticles represent nanosized colloidal entities with high relevance for both basic and applied research. When gold nanoparticles are functionalized with polymer-molecule ligands, hybrid nanoparticles emerge whose interactions with the environment are controlled by the polymer coating layer: Colloidal stabilit... |
39782881 | Naphthalene Diimide-Embedded Donor-Acceptor Carbon Nanohoops: Photophysical, Photoconductive, and Charge Transport Properties. | Designing the architecture of donor-acceptor (D-A) pairs is an effective strategy to tailor the electronic structure of conjugated macrocycles for optoelectronic devices. Herein, we present the synthesis of three D-A nanohoops <b>NDI-[<i>n</i>]CPP</b> (<i>n</i> = 7, 8, 9) containing a naphthalene diimide (NDI) unit as ... |
39782686 | Sustained inhibition of CSF1R signaling augments antitumor immunity through inhibiting tumor-associated macrophages. | Tumor-associated macrophages (TAMs) are one of the key immunosuppressive components in the tumor microenvironment (TME) and contribute to tumor development, progression, and resistance to cancer immunotherapy. Several reagents targeting TAMs have been tested in preclinical and clinical studies, but they have had limite... |
39782689 | KRASG12D drives immunosuppression in lung adenocarcinoma through paracrine signaling. | Lung cancer is the leading cause of cancer deaths in the United States. New targeted therapies against the once-deemed undruggable oncogenic KRAS are changing current therapeutic paradigms. However, resistance to targeted KRAS inhibitors almost inevitably occurs; resistance can be driven by tumor cell-intrinsic changes... |
39782489 | Photocurrent Generation by Plant Light-Harvesting Complexes is Enhanced by Lipid-Linked Chromophores in a Self-Assembled Lipid Membrane. | The light-harvesting pigment-protein complex II (LHCII) from plants can be used as a component for biohybrid photovoltaic devices, acting as a photosensitizer to increase the photocurrent generated when devices are illuminated with sunlight. LHCII is effective at photon absorption in the red and blue regions of the vis... |
39782014 | Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials. | Biopolymers, such as collagens, elastin, silk fibroin, spider silk, fibrin, keratin, and resilin have gained significant interest for their potential biomedical applications due to their biocompatibility, biodegradability, and mechanical properties. This review focuses on the design and integration of biomimetic peptid... |
39780701 | Resolving the Nanostructure of Carbon Nitride-Supported Single-Atom Catalysts. | Single-atom catalysts (SACs) are gathering significant attention in chemistry due to their unique properties, offering uniform active site distribution and enhanced selectivity. However, their precise structure often remains unclear, with multiple models proposed in the literature. Understanding the coordination enviro... |
39780688 | Predicting the Mechanical Properties of Supramolecular Gels. | The prediction of gelation is an important target, yet current models do not predict any post-gel properties. Gels can be formed through the self-assembly of many molecules, but close analogs often do not form gels. There has been success using a number of computational approaches to understand and predict gelation fro... |
39780690 | Anchorable Polymers Enabling Ultra-Thin and Robust Hole-Transporting Layers for High-Efficiency Inverted Perovskite Solar Cells. | Currently, the development of polymeric hole-transporting materials (HTMs) lags behind that of small-molecule HTMs in inverted perovskite solar cells (PSCs). A critical challenge is that conventional polymeric HTMs are incapable of forming ultra-thin and conformal coatings like self-assembly monolayers (SAMs), especial... |
39780639 | Edmundo G. Percástegui. | "My favorite principle is Molecular Self-Assembly. There is beauty in its simplicity, elegance, and the way it creates complexity and functionality… My secret/not-so-secret passion is singing and playing my guitar (it helped to make a few coins back in the day)…" Find out more about Edmundo G. Percástegui in his Introd... |
39780608 | A Multiresonant Thermally Activated Delayed Fluorescent Dendrimer with Intramolecular Energy Transfer: Application for Efficient Host-Free Green Solution-Processed Organic Light-emitting Diodes. | The development of narrowband emissive, bright, and stable solution-processed organic light-emitting diodes (SP-OLEDs) remains a challenge. Here, a strategy is presented that merges within a single emitter a TADF sensitizer responsible for exciton harvesting and an MR-TADF motif that provides bright and narrowband emis... |
39780613 | Fine-Tuning the Anisotropies of Air-Stable Single-Molecule Magnets Based on Macrocycle Ligands. | Air-stable single-molecule magnets (SMMs) can be obtained by confining Dy<sup>III</sup> ion in a <i>D</i><sub>6<i>h</i></sub> coordination environment; however, most of the current efforts were focused on modifying the rigidity of the macrocycle ligand. Herein, we attempt to assemble air-stable SMMs based on macrocycle... |
39780584 | Unraveling the Atomistic Mechanism of Electrostatic Lateral Association of Peptide β-Sheet Structures and Its Role in Nanofiber Growth and Hydrogelation. | Guiding molecular assembly of peptides into rationally engineered nanostructures remains a major hurdle against the development of functional peptide-based nanomaterials. Various non-covalent interactions come into play to drive the formation and stabilization of these assemblies, of which electrostatic interactions ar... |
39780407 | Melanin-Binding-Based Discovery of Topically Instilled Carbonic Anhydrase Inhibitors for Targeted Delivery and Prolonged Action in the Eye. | Glaucoma is a vision-threatening disease that is currently treated with intraocular-pressure-reducing eyedrops that are instilled once or multiple times daily. Unfortunately, the treatment is associated with low patient adherence and suboptimal treatment outcomes. We developed carbonic anhydrase II inhibitors (CAI-II) ... |
39780203 | Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis. | <h4>Background</h4>Cardiac fibrosis plays a critical role in the progression of various forms of heart disease, significantly increasing the risk of sudden cardiac death. However, currently, there are no therapeutic strategies available to prevent the onset of cardiac fibrosis.<h4>Methods and results</h4>Here, biomimet... |
39776076 | Ring Magnet-Guided Magnetic Manipulation for Biofabrication of 3D Cellular Structures. | Negative magnetophoresis is employed to levitate cells in a paramagnetic medium without the need for magnetic labeling, preserving their natural state and minimizing toxicity. The single-ring magnet configuration that provides an open space in the levitation chamber enhances culture accessibility and scalability, enabl... |
39773648 | A dual thermo/pH-sensitive hydrogel as 5-Fluorouracil carrier for breast cancer treatment. | Intelligent hydrogels are promising in constructing scaffolds for the controlled delivery of drugs. Here, a dual thermo- and pH-responsive hydrogel called PCG [poly ( N -isopropyl acrylamide-co-itaconic acid)/chitosan/glycerophosphate (PNI/CS/GP)] was established as the carrier of 5-fluorouracil (5-FU) for triple-negat... |
39722304 | In vivo self-assembled siRNAs within small extracellular vesicles attenuate LRRK2-induced neurodegeneration in Parkinson's disease models. | <h4>Rationale</h4>Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene play an important role in Parkinson's disease (PD) pathogenesis, and downregulation of LRRK2 has become a promising therapy for PD. Here, we developed a synthetic biology strategy for the self-assembly and delivery of small interfering RNAs (s... |
39719400 | Photoswitchable Topological Regulation of Covalent Macrocycles, Molecular Recognition, and Interlocked Structures. | Macrocycles represent one important class of functional molecules, and dynamic macrocycles with the potential of cleavability, adaptability, and topological conversion are challenging. Herein we report photoswitchable allosteric and topological control of dynamic covalent macrocycles and further the use in guest bindin... |
39719037 | Solvent-Free Chemical Recycling of Polyesters and Polycarbonates by Magnesium-Based Lewis Acid Catalyst. | Developing a simple and efficient catalyst system for closed-loop recycling of polymers to monomers is an essentially important but challenging task for the recycle of polymer wastes and preventing the downcycle of plastic products. Herein, we employ inexpensive, commercially available Lewis acids (LAs) to achieve clos... |
39716015 | Tunable Mechanically Interlocked Semi-Crystalline Networks. | High-performance polymers based on dynamic chemistry have been widely explored for multi-field advanced applications. However, noncovalent sacrificial bond-mediated energy dissipation mechanism causes a trade-off between mechanical toughness and resilience. Herein, we achieved the synchronous boost of seemingly conflic... |
39715710 | Photocatalytic Hydroxylation and Oxidative Coupling Reactions Mediated by Multinuclear Au(I) Supramolecular Clusters. | Polynuclear Au(I) cluster photocatalysts, known for their high activity and stability, hold substantial potential in organic synthetic chemistry. This study synthesized two Au(I) supramolecular cluster catalysts with different nuclearities: a tetranuclear cluster, C1 ([(dppmAu<sub>2</sub>)<sub>2</sub>L<sup>1</sup>] • P... |
39714984 | The Competition Between Cation-Anion and Cation-Triglyme Interaction in Solvate Ionic Liquids Probed by Far Infrared Spectroscopy and Molecular Dynamics Simulations. | Glyme-based electrolyte solutions provide new concepts for developing suitable lithium-ion batteries. The so-called solvate ionic liquids (SILs) are promising electrolytes. They are most efficient in equimolar mixtures of lithium bis(trifluoromethanesulfonyl)imide ([Li][NTf<sub>2</sub>]) and glyme, wherein the [Li]<sup... |
39714882 | Structural and Functional Mimicry of the Antimicrobial Defensin Plectasin by Analogues with Engineered Backbone Composition. | The threat posed by bacteria resistant to common antibiotics creates an urgent need for novel antimicrobials. Non-ribosomal peptide natural products that bind Lipid II, such as vancomycin, represent a promising source for such agents. The fungal defensin plectasin is one of a family of ribosomally produced miniproteins... |
39714819 | MOF Derived Cobalt Ferrite Cubic Rod-Like Materials for Highly Efficient Electrochemical Simultaneous Detection of Multiple Heavy Metal Ions. | A series of CoFe<sub>2</sub>O<sub>4</sub> materials derived from metal-organic framework were successfully constructed by the solvent-thermal method. The morphology of a typical sample CoFe<sub>2</sub>O<sub>4</sub>-1 was mostly in the form of a cubic rod-like structure with a size distribution of 3.2±0.2 μm, while a sm... |
39714359 | Poly(2-Hydroxymethyl-2-Oxazoline) as Super-Hydrophilic Antifouling Polymer. | Non-ionic "super-hydrophilic" polymers generally possess strong non-fouling characteristics and, therefore, can suppress non-specific and unwanted interactions with blood proteins when attached to in vivo nanomedicine ranging from drug or gene delivery to diagnostics. In this contribution, we revitalize a protected alc... |
39688265 | A heterobimetallic MOF as a stable heterogeneous catalyst with high activity for ethylene oligomerization. | Herein, the performance of heterobimetallic clusters MOF-1213(Dy/Ni) for ethylene oligomerization reactions was investigated. At 30 °C and 40 bar, its average ethylene turnover frequency is approximately 160 000 h<sup>-1</sup> (α-olefins selectivity above 80%), which was higher than the activity previously reported for... |
39676702 | Non-symmetric cysteine stapling in native peptides and proteins. | Stapling rigidifies peptides through covalent linkages between amino acids. We introduce 2-chloromethyl-6-cyanopyridine for non-symmetric stapling of N-terminal and internal cysteines. This biocompatible method produces diverse peptide macrocycles with enhanced affinity, stability and inhibitory potency. It is applicab... |
39676673 | Synthesis and Preliminary Evaluation of Tanshinone Mimic Conjugates for Mechanism of Action Studies. | Human antigen R (HuR) is an RNA binding protein (RBP) belonging to the ELAV (Embryonic Lethal Abnormal Vision) family, which stabilizes mRNAs and regulates the expression of multiple genes. Its altered expression or localization is related to pathological features such as cancer or inflammation. Dihydrotanshinone I (DH... |
39625789 | Repurposing of lonafarnib as a treatment for SARS-CoV-2 infection. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has emerged as a global pandemic pathogen with high mortality. While treatments have been developed to reduce morbidity and mortality of COVID-19, more antivirals with broad-spectrum activities are still need... |
40331011 | Same FeN4 Active Site, Different Activity: How Redox Peaks Control Oxygen Reduction on Fe Macrocycles. | Macrocycles show high activity for the electrochemical reduction of oxygen in alkaline media. However, even macrocycles with the same metal centers and MN4 active site can vary significantly in activity and selectivity, and to this date, a quantitative insight into the cause of these staggering differences has not been... |
40290773 | In-silico prediction of coat protein structure of Indian citrus ringspot virus and their interactions with the Argonaut2/DCL4 proteins. | The RNA silencing mechanism is a crucial regulatory system in plants, particularly in antiviral defense. However, most of the plant viruses encode a specific protein called RNA silencing suppressor protein that suppress the RNA silencing mechanism of host. This study employs the bioinformatics tools, including SWISS ho... |
40246455 | Selective ozone oxidation of ammonium ion catalyzed by carbon nanocage-supported Co<sub>3</sub>O<sub>4</sub>: Role of oxygen vacancies and electron transfer sites. | For the effective treatment of the wastewater with low-medium concentration ammonia nitrogen and low strength COD, a high-performance Co<sub>3</sub>O<sub>4</sub> catalyst supported on carbon nanocages (CNCs) was prepared. By isovolumetric im pregnation, Co<sub>3</sub>O<sub>4</sub> could be uniformly dispersed on surfac... |
40213069 | Correction to "Hierarchical Microcarriers Loaded with Peptide Dendrimer-Grafted Methotrexate for Rheumatoid Arthritis Treatment". | [This corrects the article DOI: 10.1002/smsc.202300097.]. |
39989782 | Crystallographic and Thermodynamic Evidence of Negative Coupling in the Flavin-Dependent Tryptophan Halogenases AbeH and BorH. | Flavin-dependent halogenases (FDHs) regioselectively halogenate aromatic substrates using halide ions, O<sub>2</sub>, and reduced flavin (FADH<sub>2</sub>) at physiological temperatures in aqueous solution, making them a green alternative to conventional synthetic methods for aryl halide preparation. To better understa... |
39896292 | Proanthocyanidin capsules remodel the ROS microenvironment via regulating MAPK signaling for accelerating diabetic wound healing. | Defective diabetic wound healing is a major clinical challenge, where hyperglycemia at the wound site induces excessive reactive oxygen species (ROS) which activate the MAPK pathway (particularly p38 MAPK), resulting in sustained release of inflammatory factors and cellular damage/apoptosis. Polyphenols are efficient R... |
39896273 | Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis. | Resveratrol (RES), a natural polyphenolic compound, has shown promise in enhancing skeletal muscle regeneration and metabolic function. This study aims to explore the impact of RES on muscle regeneration after injury through the regulation of antioxidant capacity and mitochondrial biogenesis. RES treatment significantl... |
39886581 | Native Mass Spectrometry Captures the Conformational Plasticity of Proteins with Low-Complexity Domains. | Disordered regions are an important functional feature of many multidomain proteins. A prime example is proteins in membraneless organelles, which contain folded domains that engage in specific interactions and disordered low-complexity (LC) domains that mediate liquid-liquid phase separation. Studying these complex ar... |
39886531 | Harnessing the potential of hyaluronic acid methacrylate (HAMA) hydrogel for clinical applications in orthopaedic diseases. | The treatment of orthopaedic diseases, such as fractures and osteoarthritis, remains a significant challenge due to the complex requirements for mechanical strength and tissue repair. Hydrogels based on hyaluronic acid methacrylate (HAMA) show promise as tissue engineering materials for these conditions. Hyaluronic aci... |
39886448 | Enhancing Thermogalvanic Efficiency through Electrostatic Interaction in Cationic Hydrogels. | Thermoelectric hydrogels have the potential to be used in energy conversion devices for harnessing ubiquitous low-grade heat and generating useful electricity. This can be achieved through the use of thermogalvanic cells based on redox chemistry. While significant attention has been focused toward maximizing voltage fo... |
39885946 | ULaMDyn: enhancing excited-state dynamics analysis through streamlined unsupervised learning. | The analysis of nonadiabatic molecular dynamics (NAMD) data presents significant challenges due to its high dimensionality and complexity. To address these issues, we introduce ULaMDyn, a Python-based, open-source package designed to automate the unsupervised analysis of large datasets generated by NAMD simulations. UL... |
39882471 | Safety and efficacy of sugammadex in management of patients with myasthenia gravis undergoing general anesthesia: A systematic review. | <h4>Objective</h4>The objective of this study was to analyze available evidence on efficacy and safety of sugammadex in reversing neuromuscular blockades in patients with Myasthenia Gravis (MG), thereby providing a comprehensive understanding of its potential benefits and risks in this specific patient population.<h4>M... |
39868073 | Cancer vaccine designed from homologous ferritin-based fusion protein with enhanced DC-T cell crosstalk for durable adaptive immunity against tumors. | Peptide vaccines based on tumor antigens face the challenges of rapid clearance of peptides, low immunogenicity, and immune suppressive tumor microenvironment. However, the traditional solution mainly uses exogenous substances as adjuvants or carriers to enhance innate immune responses, but excessive inflammation can d... |
39867952 | A chemically modified DNAzyme-based electrochemical sensor for binary and highly sensitive detection of reactive oxygen species. | Reactive oxygen species (ROS) play a critical role in regulating various physiological processes. To gain a comprehensive understanding of their distinct functions in different physiological events, it is imperative to detect binary ROS simultaneously. However, the development of the sensing method capable of binary RO... |
39867681 | Computational identification of novel natural inhibitors against triple mutant DNA gyrase A in fluoroquinolone-resistant <i>Salmonella</i> Typhimurium. | The rising resistance to fluoroquinolones in <i>Salmonella</i> Typhimurium poses a significant global health challenge. This computational research addresses the pressing need for new therapeutic drugs by utilizing various computational tools to identify potential natural compounds that can inhibit the triple mutant DN... |
39866605 | Highly Green Fluorescent Carbon Dots from Gallic Acid: A Turn-On Sensor toward Pb<sup>2+</sup> Ions. | Carbon dots (CDs) are emerging novel fluorescent sensing nanomaterials owing to their tunable optical properties, biocompatibility, and eco-friendliness. Herein, we report a facile one-pot hydrothermal route for the synthesis of highly green fluorescent CDs using gallic acid (GA) as a single carbon source in <i>N</i>,<... |
39861863 | A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection. | Flaviviruses are a diverse group of viruses primarily transmitted through hematophagous insects like mosquitoes and ticks. Significant expansion in the geographic range, prevalence, and vectors of flavivirus over the last 50 years has led to a dramatic increase in infections that can manifest as hemorrhagic fever or en... |
39861725 | Enhancing the Solubility of Co-Formulated Hydrophobic Drugs by Incorporating Functionalized Nano-Structured Poly Lactic-<i>co</i>-glycolic Acid (<i>nf</i>PLGA) During Co-Precipitation. | <b>Background/Objectives</b>: The co-formulation of active pharmaceutical ingredients (APIs) is a growing strategy in biopharmaceutical development, particularly when it comes to improving solubility and bioavailability. This study explores a co-precipitation method to prepare co-formulated crystals of griseofulvin (GF... |
39861209 | Metal-Coordinated Polymer-Inorganic Hybrids: Synthesis, Properties, and Application. | This review examines the recent advancements and unique properties of polymer-inorganic hybrid materials formed through coordination bonding (Class II hybrids), which enable enhanced functionality and stability across various applications. Here, we categorize these materials based on properties gained through complexat... |
39861203 | Porosity Tunable Metal-Organic Framework (MOF)-Based Composites for Energy Storage Applications: Recent Progress. | To solve the energy crisis and environmental issues, it is essential to create effective and sustainable energy conversion and storage technologies. Traditional materials for energy conversion and storage however have several drawbacks, such as poor energy density and inadequate efficiency. The advantages of MOF-based ... |
39861125 | Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid Method. | <b>Background:</b> Tumors, as intricate ecosystems, comprise oncocytes and the highly dynamic tumor stroma. Tumor stroma, representing the non-cancerous and non-cellular composition of the tumor microenvironment (TME), plays a crucial role in oncogenesis and progression, through its interactions with biological, chemic... |
39860096 | A Bis-Glycosylamine Strategy for the Synthesis of Dimeric Iminosugars Based on a DAB-1 Scaffold. | A straightforward synthetic route towards DAB-1 scaffolded dimeric iminosugars is described here, starting from readily available bis-glycosylamines. The method allows the integration of a variety of linkages (aryl, alkyl, polyethyleneglycol chains) between both iminosugars through the choice of the bis-amine used in t... |
39860098 | Synthesis and Advanced NMR Characterization of Ordered 3D Reticular Materials with PolySilicate Nodes and Hydrophobic OrganoSilicone Linkers. | This work describes the synthesis of ordered 3D siloxane-silsesquioxane reticular materials with silicate D4R cubes (Si<sub>8</sub>O<sub>20</sub><sup>8-</sup>), harvested from a sacrificial tetrabutylammonium cyclosilicate hydrate (TBA-CySH) precursor, interlinked with octyl and dicyclopentyl (Cp<sub>2</sub>) hydrocarb... |
39859199 | Adhesion Mechanism, Applications, and Challenges of Ocular Tissue Adhesives. | Corneal injury is prevalent in ophthalmology, with mild cases impacting vision and severe cases potentially resulting in permanent blindness. In clinical practice, standard treatments for corneal injury involve transplantation surgery combined with pharmacological therapy. However, surgical sutures exhibit several limi... |
39859198 | Au<sup>III</sup> Acyclic (Amino)(N-Pyridinium)carbenoids: Synthesis via Addition of 2-PySeCl to Au<sup>I</sup>-Bound Isonitriles, Structures, and Cytotoxicity. | In this study, we report the first example of acyclic (amino)(N-pyridinium)carbenoid gold(III) complexes synthesized via a coupling reaction between 2-pyridylselenyl chloride and Au(I)-bound isonitriles. The reaction involves an initial oxidative addition of the Se-Cl moiety to Au(I), followed by the nucleophilic addit... |
39859194 | Validating Structural Predictions of Conjugated Macromolecules in Espaloma-Enabled Reproducible Workflows. | We incorporated Espaloma forcefield parameterization into MoSDeF tools for performing molecular dynamics simulations of organic molecules with HOOMD-Blue. We compared equilibrium morphologies predicted for perylene and poly-3-hexylthiophene (P3HT) with the ESP-UA forcefield in the present work against prior work using ... |
39859182 | A Comparative Transcriptome and Proteome Analysis of the Molecular Mechanism Underlying Anterior to Dorsal Eye Rotation in the Celestial-Eye Goldfish (<i>Carassius auratus</i>). | Goldfish (<i>Carassius auratus</i>), subjected to millennia of artificial selection and breeding, have diversified into numerous ornamental varieties, such as the celestial-eye (CE) goldfish, noted for its unique dorsal eye rotation. Previous studies have primarily focused on anatomical modifications in CE goldfish eye... |
39857961 | <i>Proximity Labeling</i>: Precise Proteomics Technology for Mapping Receptor Protein Neighborhoods at the Cancer Cell Surface. | Cell surface receptors are pivotal to cancer cell transformation, disease progression, metastasis, early detection, targeted therapy, drug responses, and clinical outcomes. Since they coordinate complex signaling communication networks in the tumor microenvironment, mapping the physical interaction partners of cell sur... |
39857401 | Effects of Different Levels of <i>Lycium barbarum</i> Flavonoids on Growth Performance, Immunity, Intestinal Barrier and Antioxidant Capacity of Meat Ducks. | <b>Background:</b> In vitro findings on the biological functions of Lycium barbarum flavonoids (LBFs) as feed additives are limited. This study aimed to explore the effects of different concentrations of LBFs on the growth performance, immune function, intestinal barrier, and antioxidant capacity of meat ducks. A total... |
39857400 | Exploring Potential Complement Modulation Strategies for Ischemia-Reperfusion Injury in Kidney Transplantation. | The complement system plays a crucial role in regulating the inflammatory responses in kidney transplantation, potentially contributing to early decline in kidney function. Ischemia-reperfusion injury (IRI) is among the factors affecting graft outcomes and a primary contributor to delayed graft function. Complement act... |
39852826 | A Spike-Based mRNA Vaccine Encapsulated in Phospholipid 1,2-Dioleoyl-sn-Glycero-3-PhosphoEthanolamine Containing Lipid Nanoparticles Induced Potent B- and T-Cell Responses Associated with Protection Against SARS-CoV-2 Infection and COVID-19-like Symptoms in Hamsters. | <h4>Background</h4>Nucleoside-modified mRNA encapsulated in lipid nanoparticles (LNPs) have emerged as a promising vaccine strategy, especially for COVID-19. While the LNPs protect mRNA from degradation and efficiently deliver the mRNA to antigen-presenting cells, the effect of lipid composition on the immunogenicity a... |
39852080 | Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques. | Nucleic acid aptamers are single-stranded oligonucleotides that are selected through exponential enrichment (SELEX) technology from synthetic DNA/RNA libraries. These aptamers can specifically recognize and bind to target molecules, serving as specific recognition elements. Surface-enhanced Raman scattering (SERS) spec... |
39852022 | Development of Extrudable Hydrogels Based on Carboxymethyl Cellulose-Gelatin Complex Coacervates. | This study investigates the 3D extrusion printing of a carboxymethyl cellulose (CMC)-gelatin complex coacervate system. Various CMC-gelatin coacervate hydrogels were prepared and analyzed to achieve this goal. The impact of the CMC-gelatin ratio, pH, and total biopolymer concentration on coacervation formation and rheo... |
39846021 | HA198 mutations in H9N2 avian influenza: molecular dynamics insights into receptor binding. | <h4>Introduction</h4>The H9N2 avian influenza virus is widely disseminated in poultry and poses a zoonotic threat, despite vaccination efforts. Mutations at residue 198 of hemagglutinin (HA) are critical for antigenic variation and receptor-binding specificity, but the underlying molecular mechanisms remain unclear. Th... |
39845957 | Extracellular matrix re-normalization to improve cold tumor penetration by oncolytic viruses. | Immunologically inert or cold tumors pose a substantial challenge to the effectiveness of immunotherapy. The use of oncolytic viruses (OVs) to induce immunogenic cell death (ICD) in tumor cells is a well-established strategy for initiating the cancer immunity cycle (CIC). This process promotes the trafficking and infil... |
39845900 | Deciphering olfactory receptor binding mechanisms: a structural and dynamic perspective on olfactory receptors. | Olfactory receptors, classified as G-protein coupled receptors (GPCRs), have been a subject of scientific inquiry since the early 1950s. Historically, investigations into the sensory mechanisms of olfactory receptors were often confined to behavioral characteristics in model organisms or the expression of related prote... |
39845902 | Artificial molecular motors in biological applications. | Molecular motors are the cornerstone for the maintenance of living systems and mediate almost all fundamental processes involved in cellular trafficking. The intricate mechanisms underlying natural molecular motors have been elucidated in detail, inspiring researchers in various fields to construct artificial systems w... |
39845901 | Dissecting the biophysical mechanisms of oleate hydratase association with membranes. | This study investigates the dynamics of oleate hydratase (OhyA), a bacterial flavoenzyme from <i>Staphylococcus aureus</i>, and its interactions with lipid membranes, focusing on the factors influencing membrane binding and oligomerization. OhyA catalyzes the hydration of unsaturated fatty acids, playing a key role in ... |
39845453 | Case Report: Nephrotic syndrome as the primary manifestation of Alport syndrome in a Chinese pediatric patient. | <h4>Background</h4>Alport syndrome (AS) is a genetically heterogeneous disorder resulting from variants in genes coding for the alpha-3/4/5 chains of Collagen IV, leading to defective basement membranes in the kidney, cochlea, and eye. The clinical manifestations of AS vary in patients. Cases of childhood AS caused by ... |
39845374 | Nanocurcumin in myocardial infarction therapy: emerging trends and future directions. | Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Curcumin has been observed to significantly reduce pathological processes associated with MI. Its clinical application is limited due to its low bioavailability, rapid degradation, and poor solubility. Advancements in nanotechnology c... |
39845371 | Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy. | Cancer is a major killer threatening modern human health and a leading cause of death worldwide. Due to the heterogeneity and complexity of cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number of researchers and medical professionals are working to develop new ways to... |
39845318 | Mapping the intellectual structure and emerging trends on nanomaterials in colorectal cancer: a bibliometric analysis from 2003 to 2024. | <h4>Background</h4>Colorectal cancer (CRC) is one of thes most prevalent malignant tumors worldwide. Current therapeutic strategies for CRC have limitations, while nanomaterials show significant potential for diagnosing and treating CRC. This study utilizes bibliometric analysis to evaluate the current status and trend... |
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