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39845132 | A customizable wireless potentiostat for assessing Ni(OH)<sub>2</sub> decorated vertically aligned MoS<sub>2</sub> thin films for electrochemical sensing of dopamine. | In this study, we show that on-chip grown, vertically aligned MoS<sub>2</sub> films that are decorated with Ni(OH)<sub>2</sub> catalyst are suitable materials to be applied as working electrodes in electrochemical sensing. The constructed sensors display a highly repeatable response to dopamine, used as a model analyte... |
39843130 | Eco-friendly one-pot hydrothermal synthesis of cyclodextrin metal-organic frameworks for enhanced CO<sub>2</sub> capture. | Polysaccharide-based metal-organic frameworks have attracted widespread attention due to their combination of the biocompatibility and flexibility of polysaccharides. Cyclodextrin are interesting bio-ligands in the construction of polysaccharide-based MOFs. Conventional methods for preparing cyclodextrin metal-organic ... |
39840294 | A comparative investigation on excimer fluorescence toward its bright future. | Must excimers quench fluorescence? This study aims to clarify the misconception that excimers are defective species with weak fluorescence. For this purpose, we utilized a rigid xanthene template to connect anthracene units for constructing an inter-excimer and an intra-excimer. Their photophysical properties were syst... |
39831263 | Mixed-phase enabled high-rate copper niobate anodes for lithium-ion batteries. | The advancement of rapid-response grid energy storage systems and the widespread adoption of electric vehicles are significantly hindered by the charging times and energy densities associated with current lithium-ion battery technology. In state-of-the-art lithium-ion batteries, graphite is employed as the standard neg... |
39829982 | Identify structures underlying out-of-equilibrium reaction networks with random graph analysis. | Network measures have proven very successful in identifying structural patterns in complex systems (<i>e.g.</i>, a living cell, a neural network, the Internet). How such measures can be applied to understand the rational and experimental design of chemical reaction networks (CRNs) is unknown. Here, we develop a procedu... |
39813781 | Tunable architecture of cobalt-nickel metal-organic framework/activated carbon composites for superior electrochemical performance in asymmetric supercapacitors. | Cobalt-nickel metal-organic framework/activated carbon (MOF/AC) composites with tunable flower-like architectures were synthesized via a straightforward hydrothermal method, utilizing activated carbon as a structural and functional modifier. This modification increased the surface area from 20.3 m<sup>2</sup>/g to 164.... |
39811685 | Hot shape transformation: the role of PSar dehydration in stomatocyte morphogenesis. | Polysarcosine emerges as a promising alternative to polyethylene glycol (PEG) in biomedical applications, boasting advantages in biocompatibility and degradability. While the self-assembly behavior of block copolymers containing polysarcosine-containing polymers has been reported, their potential for shape transformati... |
39811001 | A 3D four-fold interpenetrated conductive metal-organic framework for fast and robust sodium-ion storage. | Two-dimensional conductive metal-organic frameworks (2D c-MOFs) with high electrical conductivity and tunable structures hold significant promise for applications in metal-ion batteries. However, the construction of 3D interpenetrated c-MOFs for applications in metal-ion batteries is rarely reported. Herein, a 3D four-... |
39802377 | A Ferritin-Based Eg95 Nanoparticle Vaccine Adjuvanted with pCpG Eliciting Robust Immune Responses Against Cystic Echinococcosis in Mice Model. | <h4>Introduction</h4>Cystic echinococcosis (CE), a chronic disabling parasitic zoonosis, poses a great threat to public health and livestock production and causes huge economic losses globally. The commercial Quil-A-adjuvanted Eg95 vaccine was empirically effective for CE control; however, it is expensive and has side ... |
39799690 | Determination of five alternaria toxins in peppermint by dispersive solid-phase extraction coupled with ultra-high performance liquid chromatography-tandem mass spectrometry based on MOF-808-TFA. | An efficient and rapid ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MSMS) method was developed for simultaneous determination of 5 alternaria toxins (ATs) in edible and medicinal plant - peppermint using MOF-808-trifluoroacetic acid (MOF-808-TFA) as the adsorbent. Characterization method... |
39799625 | Multifunctional porphyrinic metal-organic framework-based nanoplatform regulating reactive oxygen species achieves efficient imaging-guided cascaded nanocatalytic therapy. | The integration of reactive oxygen species (ROS) related photodynamic therapy (PDT) with the strategy of reshaping the tumor microenvironment (TME) has emerged as a potential approach for nanodiagnostic and therapeutic interventions. However, the therapeutic efficacy based on ROS treatments may be hindered by intracell... |
39793832 | Construction of GOx-loaded metal organic frameworks antibacterial composite hydrogels for skin wound healing. | Bacterial infections and inflammation severely impede wound healing. Here, we developed a zwitterionic hydrogel incorporating MOF/GOx for pH-responsive, controlled drug release. The multifunctional hydrogel embedded with MOF/GOx was successfully prepared through the Schiff base reaction between the copolymer poly[(2-me... |
39793810 | Confinement of carbon dots into carboxymethyl cellulose matrice to prepare solid-state fluorescent films and couple with Eu-MOF toward white light-emitting diodes. | As a novel fluorescent carbon nanomaterial, carbon dots are restricted by their poor fluorescence in the solid state, although they exhibit favorable photoluminescence in solution. N-doped carbon dots (N-CDs) and solid-state fluorescence films were prepared using green and renewable cellulose-derived materials, respect... |
39793719 | Study on the impact of β-CD inclusion complex on the in vivo metabolism of ginsenoside Re: A pharmacokinetic, metabolite analysis, and tissue distribution investigation in a rat model. | Triol-type ginsenoside Re (GS-Re) exhibits potent anti-myocardial ischemia-reperfusion effects, but its clinical use is hindered by poor bioavailability. This study evaluates the impact of β-cyclodextrin (β-CD) inclusion on GS-Re bioavailability and tissue dynamics in rat models. The GS-Re-β-CD complex was prepared usi... |
39793353 | A cinnamon and clove essential oil mix microencapsulated with hydroxypropyl-β-cyclodextrin: Study on physicochemical, antibacterial, and low salt pickles preservation properties. | In order to overcome the technical challenges of poor stability and weak antibacterial effects of individual essential oil in food preservation applications, the present study aimed to encapsulate cinnamon and clove essential oil compound by using spray-drying technique. The combination of cinnamon and clove essential ... |
39790235 | Engaging a highly fluorescent conjugated polymer network for probing endogenous hypochlorite in macrophage cells: improved sensitivity <i>via</i> signal amplification. | We have employed a triazine-based conjugated polymer network (CPN) for the selective detection of hypochlorite in a semi-aqueous environment. CPNs have been widely employed in gas capture, separation, and adsorption, but the fluorescent properties of CPNs possessing extensive π-conjugated systems tend to be unexplored.... |
39788859 | Prebiotic RNA self-assembling and the origin of life: Mechanistic and molecular modeling rationale for explaining the prebiotic origin and replication of RNA. | In recent years, a great interest has been focused on the prebiotic origin of nucleic acids and life on Earth. An attractive idea is that life was initially based on an autocatalytic and autoreplicative RNA (the RNA-world). RNA duplexes are right-handed helical chains with antiparallel orientation, but the rationale fo... |
39787923 | Hydroxyl-induced structural defects in metal-organic frameworks for improved photocatalytic decontamination: Accelerated exciton dissociation and hydrogen bonding interaction. | The introduction of structural defects can improve the charge separation efficiency of metal-organic frameworks (MOFs)-based photocatalysts, which however come with suboptimal decontamination performance, due to steric hindrance and limited binding capacity of the involved modulators. In this work, hydroxyl group captu... |
39780973 | Recent advances in metal-catalysed oxidation reactions. | Oxidation reactions are vital tools in synthetic organic chemistry. Oxidation of organic species such as alcohols, phenols, aldehydes and ketones provides synthetically valuable organic compounds, especially synthetic intermediates for several biologically active compounds. Some of these synthetic intermediates have sh... |
39780966 | Unexpected stability of the iron(II) complex by an asymmetrical Schiff base from Fe(III): structure, magnetic and Mössbauer investigations. | The asymmetric Schiff base prepared <i>in situ</i> from ethylenediamine and pyridine-2-carboxaldehyde reacts with Fe(ClO<sub>4</sub>)<sub>3</sub>·6H<sub>2</sub>O to form the Fe(II) complex [FeL<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> with L = <i>N</i>,<i>N</i>-diethyl-<i>N</i>'-(pyridin-2-yl)methylene)ethane-1,2-diam... |
39780275 | Breaking boundaries: role of the brain barriers in metastatic process. | Brain metastases (BMs) are the most common intracranial tumors in adults and occur 3-10 times more frequently than primary brain tumors. Despite intensive multimodal therapies, including resection, radiotherapy, and chemotherapy, BMs are associated with poor prognosis and remain challenging to treat. BMs predominantly ... |
39780215 | An integrative analysis reveals cancer risk associated with artificial sweeteners. | <h4>Background</h4>Artificial sweeteners (AS) have been widely utilized in the food, beverage, and pharmaceutical industries for decades. While numerous publications have suggested a potential link between AS and diseases, particularly cancer, controversy still surrounds this issue. This study aims to investigate the a... |
39780009 | Dynamic supramolecular snub cubes. | Mimicking the superstructures and properties of spherical biological encapsulants such as viral capsids<sup>1</sup> and ferritin<sup>2</sup> offers viable pathways to understand their chiral assemblies and functional roles in living systems. However, stereospecific assembly of artificial polyhedra with mechanical prope... |
39779970 | Self-assembly of chiroptical ionic co-crystals from silver nanoclusters and organic macrocycles. | Atomically precise nanoclusters can be assembled into ordered superlattices with unique electronic, magnetic, optical and catalytic properties. The co-crystallization of nanoclusters with functional organic molecules provides opportunities to access an even wider range of structures and properties, but can be challengi... |
39779971 | A pseudo-cubic metal-organic cage with conformationally switchable faces for dynamically adaptive guest encapsulation. | The creation of hosts capable of accommodating different guest molecules may enable these hosts to play useful roles in chemical purifications, among other applications. Metal-organic cages are excellent hosts for various guests, but they generally incorporate rigid structural units that hinder dynamic adaptation to sp... |
39779901 | Population-level amplification of gene regulation by programmable gene transfer. | Engineering cells to sense and respond to environmental cues often focuses on maximizing gene regulation at the single-cell level. Inspired by population-level control mechanisms like the immune response, we demonstrate dynamic control and amplification of gene regulation in bacterial populations using programmable pla... |
39779880 | Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection. | To overtake competitors, microbes produce and secrete secondary metabolites that kill neighbouring cells and sequester nutrients. This metabolite-mediated competition probably evolved in complex microbial communities in the presence of viral pathogens. We therefore hypothesized that microbes secrete natural products th... |
39779694 | Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region. | One of the hallmarks of RNA viruses is highly structured untranslated regions (UTRs) which are often essential for viral replication, transcription, or translation. In this report, we discovered a series of coumarin derivatives that bind to a four-way RNA helix called SL5 in the 5' UTR of the SARS-CoV-2 RNA genome. To ... |
39779671 | Organocatalytic enantioselective synthesis of double S-shaped quadruple helicene-like molecules. | Helicene-shaped molecules are compelling chemical structures with unique twisted helical chirality and remarkable properties. Although progress occurs in the catalytic asymmetric synthesis of helicene (-like) molecules, the enantioselective synthesis of multiple helicenes, especially four or higher helicity, is still c... |
39779582 | Inclusion Complex of Nimodipine with Sulfobutylether-β-cyclodextrin: Preparation, Characterization, In Vitro and In Vivo Evaluation. | Nimodipine (NIMO) is used to treat ischemic nerve injury from subarachnoid hemorrhage (SAH), but its low aqueous solubility limits clinical safety and bioavailability. This study aims to improve NIMO's solubility by preparing inclusion complexes with sulfobutylether-β-cyclodextrin (SBE-β-CD), reducing the limitations o... |
39779489 | Design and Construction of a Porphyrin-Based Samarium(III)-Metal-Organic Framework for Antibiotic Detection. | Porphyrins bearing the unique 18π electron tetrapyrrolic macrocycles exhibit interesting photophysical and photochemical properties and have been considered as promising ligands for the construction of functionalized metal-organic frameworks (MOFs). The combination of porphyrin-type ligands with lanthanide metals featu... |
39779487 | Living Cell-Mediated Self-Assembly: From Monomer Design and Morphology Regulation to Biomedical Applications. | The self-assembly of molecules into highly ordered architectures is a ubiquitous and natural process, wherein molecules spontaneously organize into large structures to perform diverse functions. Drawing inspiration from the formation of natural nanostructures, cell-mediated self-assembly has been developed to create fu... |
39779459 | Biocompatible 2D Material Inks Enabled by Supramolecular Chemistry: From Synthesis to Applications. | ConspectusThe emergence of two-dimensional (2D) materials, such as graphene, transition-metal dichalcogenides (TMDs), and hexagonal boron nitride (h-BN), has sparked significant interest due to their unique physicochemical, optical, electrical, and mechanical properties. Furthermore, their atomically thin nature enable... |
39779305 | Solid Lipid Nanoparticles Coated with Glucosylated poly(2-oxazoline)s: A Supramolecular Toolbox Approach. | Multifunctional polymers are interesting substances for the formulation of drug molecules that cannot be administered in their pure form due to their pharmacokinetic profiles or side effects. Polymer-drug formulations can enhance pharmacological properties or create tissue specificity by encapsulating the drug into nan... |
39778908 | Hydration and Biodistribution of Zwitterionic Dendrimers Conjugating a Sulfobetaine Monomer and Polymers. | Zwitterionic polymers exhibit strong hydration, high biocompatibility, and antifouling properties. Dendrimers are regularly branched polymers, which are used in the drug delivery system (DDS). In this study, we synthesized zwitterionic monomer- and polymer-conjugated dendrimers as a biocompatible nanoparticle to invest... |
39778704 | Operando Photoelectrochemical Surface-Enhanced Raman Spectroscopy: Interfacial Mechanistic Insights and Simultaneous Detection of Patulin. | Comprehending the biosensing mechanism of the biosensor interface is crucial for sensor development, yet accurately reflecting interfacial interactions within actual detection environments remains an unsolved challenge. An operando photoelectrochemical surface-enhanced Raman spectroscopy (PEC-SERS) biosensing platform ... |
39778588 | Chromic Electrospun Polymer Nanofibers: Preparation, Applications, and the Future. | Physical understanding and determination of different analytes without the need for advanced and additional equipment are highly important, which can be achieved by using stimuli-induced chromic materials. Physical and chemical incorporation of responsive chromophores into different polymers results in the fabrication ... |
39778151 | Leveraging Cross-Diversity Machine Learning to Unveil Metal-Organic Frameworks with Open Copper Sites for Biogas Upgrading. | Biogas, primarily composed of methane (CH<sub>4</sub>) and carbon dioxide (CO<sub>2</sub>), is considered an alternative renewable energy resource. Efficient CO<sub>2</sub>/CH<sub>4</sub> separation is essential for biogas upgrading to increase energy density, and in this context, metal-organic frameworks (MOFs) have d... |
39778132 | Insights into the MOF-Based Classic Configuration for the Differences in Effective Dye Adsorption, Magnetic Properties, and Computational Analyses. | Two 3D/2D anionic metal-organic frameworks (MOFs), [Cu(HL)]<sub><i>n</i></sub> (<b>1</b>) and [Mn<sub>3</sub>(L)<sub>2</sub>(DMF)<sub>4</sub>]<sub><i>n</i></sub> (<b>2)</b> (DMF = <i>N</i>,<i>N</i>-dimethylformamide), were synthesized by the solvothermal reaction of metal salts and 5'-(4-carboxyphenyl)-2',4',6'-triethy... |
39777633 | Plant Cell Wall-Like Soft Materials: Micro- and Nanoengineering, Properties, and Applications. | Plant cell wall (CW)-like soft materials, referred to as artificial CWs, are composites of assembled polymers containing micro-/nanoparticles or fibers/fibrils that are designed to mimic the composition, structure, and mechanics of plant CWs. CW-like materials have recently emerged to test hypotheses pertaining to the ... |
39773606 | Neurosteroid replacement therapy using tiagabine and zuranolone restores cerebellar neurodevelopment and reduces hyperactive behaviour following preterm birth. | Preterm birth exposes the neonate to hypoxic-ischaemic and excitotoxic insults that impair neurodevelopment and are magnified by the premature loss of placentally supplied, inhibitory neurosteroids. The cerebellum is a neuronally dense brain region, which undergoes critical periods of development during late gestation,... |
39773260 | Phage display technology in ecotoxicology: phage display derived unique peptide for copper identification in aquatic samples. | <h4>Background</h4>Ecotoxicology is essential for the evaluation and comprehension of the effects of emergency pollutants (EP) such as heavy metal ions on the natural environment. EPs pose a substantial threat to the health of humans and the proper functioning of the global ecosystem. The primary concern is the exposur... |
39772852 | Platelet factor 4-derived C15 peptide broadly inhibits enteroviruses by disrupting viral attachment. | Platelet factor 4 (PF4) has been shown to regulate several viral infections. Our previous study demonstrated that PF4 inhibits the entry of enterovirus A 71 (EV71) and coxsackievirus A16 (CA16), which cause hand, foot, and mouth disease (HFMD). In this study, we report that PF4 also inhibits the circulating HFMD pathog... |
39772849 | Impact of composition and surfactant-templating on mesoporous bioactive glasses structural evolution, bioactivity, and drug delivery property. | This study explores mesoporous bioactive glasses (MBGs) that show promise as advanced therapeutic delivery platforms owing to their tailorable porous properties enabling enhanced drug loading capacity and biomimetic chemistry for localized, sustained release. This work systematically investigates the complex relationsh... |
39772807 | Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide. | The enterobacterial common antigen (ECA) is conserved in Gram-negative bacteria of the <i>Enterobacterales</i> order although its function is debated. ECA biogenesis depends on the Wzx/Wzy-dependent strategy whereby the newly synthesized lipid-linked repeat units, lipid III, are transferred across the inner membrane by... |
39772731 | Preparation and application of porcine broadly neutralizing monoclonal antibodies in an immunoassay for efficiently detecting neutralizing antibodies against foot-and-mouth disease virus serotype O. | Neutralizing antibodies provide vital protection against foot-and-mouth disease virus (FMDV). The virus neutralization test (VNT) is a gold standard method for the detection of neutralizing antibodies. However, its application is limited due to the requirement for live virus and unsuitability for large-scale serologica... |
39772695 | Blocking the isoflavone chemoreceptor in <i>Phytophthora sojae</i> to prevent disease. | Inhibiting pathogen chemotaxis is a promising strategy for reducing disease pressure. However, this strategy is currently in the proof-of-concept stage. Here, <i>Phytophthora sojae</i> was used as a model, as its biflagellated zoospores could sense genistein, a soybean root exudate, to navigate host and initiate infect... |
39772687 | Metal-organic frameworks as thermocatalysts for hydrogen peroxide generation and environmental antibacterial applications. | Reactive oxygen species (ROS) are highly reactive, making them useful for environmental and health applications. Traditionally, photocatalysts and piezocatalysts have been used to generate ROS, but their utilization is limited by various environmental and physical constraints. This study introduces metal-organic framew... |
39772674 | Advances in engineering nanoparticles for magnetic particle imaging (MPI). | Magnetic particle imaging (MPI) is an emerging imaging modality with exciting biomedical applications, such as cell tracking, blood pool imaging, and image-guided magnetic hyperthermia. MPI is unique in that signal is generated entirely by synthetic nanoparticle tracers, motivating precise engineering of magnetic nanop... |
39772601 | Probing Macromolecular Conformation in Restricted Geometry by PEF: Application to Hydrophobically Modified PAMAM Dendrimers Isolated Inside Surfactant Micelles. | The conformation of a series of zero-generation polyamidoamine dendrimers end-labeled with four 1-pyrene-butyroyl, -hexanoyl, -octanoyl, -decanoyl, and -dodecanoyl derivatives, referred to as the PyCX-PAMAM-G0 samples with <i>X</i> = 4, 6, 8, 10, and 12, respectively, was characterized in <i>N</i>,<i>N</i>-dimethylform... |
39772594 | Engineering Protein Dynamics through Mutational Energy Landscape Traps. | Protein dynamics is essential for various biological processes, influencing functions such as enzyme activity, molecular recognition, and signal transduction. However, traditional protein engineering methods often focus on static structures, lacking tools to precisely manipulate dynamic behaviors. Here, we developed Mu... |
39772535 | Metabolic Stability and Targeted Delivery of Oligonucleotides: Advancing RNA Therapeutics Beyond The Liver. | Oligonucleotides have emerged as a formidable new class of nucleic acid therapeutics. Fully modified oligonucleotides exhibit enhanced metabolic stability and display successful clinical applicability for targets formerly considered "undruggable". Accumulating studies show that conjugation to targeting modalities of st... |
39772496 | Metal-Organic Framework with Open Metal Sites for D<sub>2</sub>/H<sub>2</sub> Separation. | The separation of hydrogen isotopes remains a significant challenge due to their nearly identical physicochemical properties. Recently, metal-organic frameworks employing the chemical affinity quantum sieving effect have garnered increasing attention for hydrogen isotope separation. In this study, <b>Cu-BTT</b> with op... |
39772492 | Boron-Doped Endohedral Metallofullerenes: Synthesis and Computational Analysis of a Family of Heteroatom-Doped Molecular Carbons. | Gas-phase synthesis and detection of boron-doped nitride clusterfullerenes and a large variety of monometallofullerenes have been achieved using a pulsed laser vaporization cluster source. Density functional theory (DFT) calculations show that the electronic structures of boron-doped endohedral metallofullerenes differ... |
39772484 | Sequence-Defined DNA Polymers: New Tools for DNA Nanotechnology and Nucleic Acid Therapy. | Structural DNA nanotechnology offers a unique self-assembly toolbox to construct soft materials of arbitrary complexity, through bottom-up approaches including DNA origami, brick, wireframe, and tile-based assemblies. This toolbox can be expanded by incorporating interactions orthogonal to DNA base-pairing such as meta... |
39772463 | Overscreening-Driven Modulation of Ion Adsorption and Desorption in Conductive MOF Electrodes by Charging Rates. | Elucidating the charging mechanism plays an intrinsic and critical role in the development of high-performance supercapacitors; however, a deep understanding of how this mechanism varies under different charging rates remains challenging. In this study, we investigate the charging mechanism of conductive metal-organic ... |
39772443 | Spectroscopic and Computational Insights into the Mechanism of Cofactor Cobalt-Carbon Bond Homolysis by the Adenosylcobalamin-Dependent Enzyme Ethanolamine Ammonia-Lyase. | The adenosylcobalamin (AdoCbl)-dependent enzyme ethanolamine ammonia-lyase (EAL) catalyzes the conversion of ethanolamine to acetaldehyde and ammonia. As is the case for all AdoCbl-dependent isomerases, the catalytic cycle of EAL is initiated by homolytic cleavage of the cofactor's Co-C bond, producing Co<sup>II</sup>c... |
39756686 | Combating cisplatin-resistant lung cancer using a coiled-coil lipopeptides modified membrane fused drug delivery system. | Drug resistance to chemotherapy in treating cancers becomes an increasingly serious challenge, which leads to treatment failure and poor patient survival. Drug-resistant cancer cells normally reduce intracellular accumulation of drugs by controlling drug uptake and promoting drug efflux, which severely limits the effic... |
39733913 | Controlling vaccine kinetics using tannic acid for enhanced humoral immunity. | Despite the success of global vaccination campaigns, vaccine access in low-resource settings is an ongoing challenge. Subunit vaccines are a well-established and clinically scalable intervention, yet they have achieved limited success for poorly immunogenic antigens such as those associated with SARS-CoV-2. Delivery st... |
39714367 | Visible-Light-Driven CO₂ Reduction Using Imidazole-Based Metal-Organic Frameworks as Heterogeneous Photocatalysts. | The development of robust, efficient, and cost-effective heterogeneous photocatalysts for visible light-driven CO<sub>2</sub> reduction continues to be a significant challenge in the quest for sustainable energy solutions. As a result, increasing attention is being directed towards the exploration of high-performance p... |
39714365 | Single-Atom Based Metal-Organic Frameworks for Efficient C-S Cross-Coupling. | Single-atom-based Metal-Organic Frameworks (MOFs) hold great promising candidates for heterogeneous catalysis, demonstrating outstanding catalytic activity and exceptional product selectivity. This is attributed to their optimal atom utilization, high surface energy, and the presence of unsaturated coordination environ... |
39714342 | Highly Selective Construction of Unique Cyclic [4]Catenanes Induced by Multiple Noncovalent Interactions. | The synthesis of high-ordered mechanically interlocked supramolecular structures is an extremely challenging topic. Only two linear [4]catenanes have been reported so far and there is no defined strategy to obtain cyclic [4]catenane. Herein, two unprecedented cyclic [4]catenanes, 1 and 2, were prepared in high yields. ... |
39688878 | Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases. | Tau, a microtubule-associated protein, plays a critical role in maintaining neuronal structure and function. However, in neurodegenerative diseases such as Alzheimer's disease and other tauopathies, tau misfolds and aggregates into oligomers and fibrils, leading to neuronal damage. Tau oligomers are increasingly recogn... |
39673369 | Advances in Chiral Macrocycles: Molecular Design and Applications. | Chiral macrocycles have recently emerged as promising materials for enantioselective recognition, asymmetric catalysis, and circularly polarized luminescence (CPL) due to their terminal-free structure, preorganized chiral cavities, and unique host-guest and self-assembly properties. This review summarizes recent advanc... |
39482250 | Targeting Long Noncoding RNA H19 in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in Osteoarthritis. | <h4>Objective</h4>Emerging evidence suggests long noncoding RNA H19 is associated with osteoarthritis (OA) pathology. However, how H19 contributes to OA has not been reported. This study aims to investigate the biologic function of H19 in OA subchondral bone remodeling and OA progression.<h4>Methods</h4>Clinical joint ... |
39297221 | NMR crystallization: <i>in situ</i> NMR strategies for monitoring the evolution of crystallization processes. | We present a discussion of the range of NMR techniques that have been utilized for <i>in situ</i> monitoring of crystallization processes, highlighting the opportunities that now exist for exploiting the versatility of NMR techniques to reveal insights into the changes that occur in both the solid phase and the liquid ... |
39291762 | Probing assembly/disassembly of ordered molecular hydrogels. | Supramolecular hydrogels have a wide range of applications in the biomedical field, acting as scaffolds for cell culture, matrices for tissue engineering and vehicles for drug delivery. L-Phenylalanine (Phe) is a natural amino acid that plays a significant role in several physiological and pathophysiological processes ... |
39258887 | High-throughput calculations and machine learning modeling of <sup>17</sup>O NMR in non-magnetic oxides. | The only NMR-active oxygen isotope, oxygen-17 (<sup>17</sup>O), serves as a sensitive probe due to its large chemical shift range, the electric field gradient at the oxygen site, and the quadrupolar interaction. Consequently, <sup>17</sup>O solid-state NMR offers unique insights into local structures and finds signific... |
40256709 | Research advancements in molecular glues derived from natural product scaffolds: Chemistry, targets, and molecular mechanisms. | The mechanism of action of traditional Chinese medicine (TCM) remains unclear. Historically, research on TCM has mainly focused on exploring the mechanisms of active components acting on single targets. However, it is insufficient to explain the complex mechanisms by which these active components in TCM treat diseases.... |
40224956 | Plant-Origin Compounds and Materials for Advancing Bone Tissue Engineering and 3D Bioprinting: Traditional Medicine Aspects and Current Perspectives. | Bone defects are becoming a true challenge in global health care due to the aging population and higher prevalence of musculoskeletal disorders. The interest in using plant-origin compounds and plant-derived biomaterials in bone tissue engineering (BTE) has been increased due to their availability (abundance), safety, ... |
40213184 | Heat shock protein and Alzheimer's disease: an updated systematic review. | <h4>Background</h4>Alzheimer's disease (AD) is widely acknowledged as a global medical and social concern, and is characterized by the absence of a definitive cure. One of the primary challenges in AD research is the difficulty in targeting and isolating the intricate biochemical pathways that are implicated in the dis... |
40041032 | An <sub>e</sub>pH-driven DNA nanodevice for impeding metastasis <i>in vivo</i> by selectively blocking cell signaling. | Invasion and metastasis dominate tumor progression, causing a substantial proportion of cancer-related deaths. However, the efficacy of current antimetastatic treatments is hampered by the dearth of targeted therapeutics. Recently developed synthetic-receptor toolkits offer potential for artificially regulating cellula... |
40028350 | Insights into IrtAB: Iron Transport Facilitates Ultrasensitive Detection of <i>Mycobacteria</i> in Both Cellular and Clinical Environments. | <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) utilizes a heterodimeric ABC transporter (IrtAB) to extract Fe<sup>3+</sup> ions from host cells. This study demonstrates that ultrasensitive fluorescent probes, achieved through the conjugation of fluorophores with the ligand of IrtAB, N14G and N14G-Fe can detect <i>Mycob... |
39906563 | Nanozyme-based wearable biosensors for application in healthcare. | Recent years have witnessed tremendous advances in wearable sensors, which play an essential role in personalized healthcare for their ability for real-time sensing and detection of human health information. Nanozymes, capable of mimicking the functions of natural enzymes and addressing their limitations, possess uniqu... |
39886443 | Mutually antagonistic molecular clips: symmetry-breaking non-covalent bonds at the chiral-nonchiral interface. | The homochirality of life remains an unresolved scientific question. Prevailing models postulate that homochirality arose through mutual antagonism. In this mechanism, molecules of opposite handedness deactivate each other, amplifying even a small enantiomeric excess into a larger proportion. In this paper, we present ... |
39868351 | Innovating intervertebral disc degeneration therapy: Harnessing the power of extracellular vesicles. | Intervertebral disc degeneration is the leading cause of low back pain, imposing significant burdens on patients, societies, and economies. Advancements in regenerative medicine have spotlighted extracellular vesicles as promising nanoparticles for intervertebral disc degeneration treatment. Extracellular vesicles reta... |
39866595 | Chiral Recognition of Butylone by Methylated β-Cyclodextrin Inclusion Complexes: Molecular Calculations and Two-Level Factorial Designs. | The integration of molecular docking and AM1 calculations has elucidated the complexation behavior of butylone enantiomers with methylated β-cyclodextrin derivatives. Our study reveals that butylone can adopt two distinct conformations within the β-cyclodextrin cavity, with one conformation being preferentially stabili... |
39861718 | Emerging Nanoparticle-Based Diagnostics and Therapeutics for Cancer: Innovations and Challenges. | Malignant growth is expected to surpass other significant causes of death as one of the top reasons for dismalness and mortality worldwide. According to a World Health Organization (WHO) study, this illness causes approximately between 9 and 10 million instances of deaths annually. Chemotherapy, radiation, and surgery ... |
39861121 | Current Insight of Peptide-Based Hydrogels for Chronic Wound Healing Applications: A Concise Review. | Chronic wounds present a substantial healthcare obstacle, marked by an extended healing period that can persist for weeks, months, or even years. Typically, they do not progress through the usual phases of healing, which include hemostasis, inflammation, proliferation, and remodeling, within the expected timeframe. The... |
39860079 | Comparison of In Situ and Postsynthetic Formation of MOF-Carbon Composites as Electrocatalysts for the Alkaline Oxygen Evolution Reaction (OER). | Mixed-metal nickel-iron, Ni<sub>x</sub>Fe materials draw attention as affordable earth-abundant electrocatalysts for the oxygen evolution reaction (OER). Here, nickel and mixed-metal nickel-iron metal-organic framework (MOF) composites with the carbon materials ketjenblack (KB) or carbon nanotubes (CNT) were synthesize... |
39859162 | Concise Overview of Methodologies Employed in the Study of Bacterial DNA Replication. | DNA replication is a fundamental process in the cell on which the functioning of the entire cell as well as the maintenance of the entire species depends. This process is synchronized with all other processes within the cell as well as with external, environmental factors. This complex network of interconnections prese... |
39859150 | Transcriptomic Insights into Post-Spawning Death and Muscle Atrophy in Ayu (<i>Plecoglossus altivelis</i>). | In semelparous species like the ayu (<i>Plecoglossus altivelis</i>), spawning is followed by rapid physiological decline and death; yet, the underlying molecular mechanisms remain largely unexplored. This study examines transcriptomic changes in ayu skeletal muscle before and after spawning, with a focus on key genes a... |
39858469 | TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses. | TMPRSS2, a human transmembrane protease enzyme, plays a crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving viral glycoproteins, which helps viruses like SARS-CoV-2 and influenza A enter cells more effectively. Genetic differences in TMP... |
39858123 | Alleviating <i>Clostridium perfringens</i>-Induced Intestinal Lesions in Chickens Using the Xylanase <i>Cb</i>Xyn10C and Its Binary Cocktail with a Protease. | <i>Clostridium perfringens</i> infection can induce necrotic enteritis and lead to significant economic loss to the chicken industry. In this study, a xylanase (<i>Cb</i>Xyn10C), which effectively promotes the growth of probiotics, and a protease, which degrades the biofilm of <i>C. perfringens,</i> were analyzed for t... |
39857706 | Novel Poly-Arginine Peptide R18D Reduces α-Synuclein Aggregation and Uptake of α-Synuclein Seeds in Cortical Neurons. | <h4>Background/objectives</h4>The role of α-synuclein (α-syn) pathology in Parkinson's disease (PD) is well established; however, effective therapies remain elusive. Two mechanisms central to PD neurodegeneration are the intracellular aggregation of misfolded α-syn and the uptake of α-syn aggregates into neurons. Catio... |
39852696 | Research on Red/Near-Infrared Fluorescent Carbon Dots Based on Different Carbon Sources and Solvents: Fluorescence Mechanism and Biological Applications. | Fluorescent carbon dots, especially red/near-infrared-emitting CDs, are becoming increasingly important in the field of biomedicine. This article reviews the synthesis, fluorescence mechanisms, and biological applications of R/NIR-CDs, emphasizing the importance of carbon source and solvent selection in controlling the... |
39852078 | Fluorogenic Biosensing with Tunable Polydiacetylene Vesicles. | Polydiacetylenes (PDAs) are conjugated polymers that are well known for their colorimetric transition from blue to red with the application of energetic stimulus. Sensing platforms based on polymerized diacetylene surfactant vesicles and other structures have been widely demonstrated for various colorimetric biosensing... |
39851499 | Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial-Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cell Lines. | Metastasizing cancer cells surreptitiously can adapt to metabolic activity during their invasion. By initiating their communications for invasion, cancer cells can reprogram their cellular activities to initiate their proliferation and migration and uniquely counteract metabolic stress during their progression. During ... |
39851496 | TRIM25: A Global Player of Cell Death Pathways and Promising Target of Tumor-Sensitizing Therapies. | Therapy resistance still constitutes a common hurdle in the treatment of many human cancers and is a major reason for treatment failure and patient relapse, concomitantly with a dismal prognosis. In addition to "intrinsic resistance", e.g., acquired by random mutations, cancer cells typically escape from certain treatm... |
39851489 | Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy. | In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, espec... |
39850253 | Proximity-enhanced cysteine-histidine crosslinking for elucidating intrinsically disordered and other protein complexes. | Disordered proteins and domains are ubiquitous throughout the proteome of human cell types, yet the biomolecular sciences lack effective tool compounds and chemical strategies to study this class of proteins. In this context, we introduce a novel covalent tool compound approach that combines proximity-enhanced crosslin... |
39846612 | How Broadly Neutralising Antibodies Are Redefining Immunity to Influenza. | Recent avian influenza outbreaks have heightened global concern over viral threats with the potential to significantly impact human health. Influenza is particularly alarming due to its history of causing pandemics and zoonotic reservoirs. In response, significant progress has been made toward the development of univer... |
39845903 | The N17 domain of huntingtin as a multifaceted player in Huntington's disease. | Huntington's disease (HD) is primarily caused by the aberrant aggregation of the N-terminal exon 1 fragment of mutant huntingtin protein (mHttex1) with expanded polyglutamine (polyQ) repeats in neurons. The first 17 amino acids of the N-terminus of Httex1 (N17 domain) immediately preceding the polyQ repeat domain are e... |
39845785 | Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy. | Recurrent spontaneous seizures with an extended epileptic discharge are the hallmarks of epilepsy. At present, there are several available anti-epileptic drugs (AEDs) in the market. Still no adequate treatment for epilepsy treatment is available. The main disadvantages of AEDs are their associated adverse effects. It i... |
39845568 | Reliable and robust robotic handling of microplates via computer vision and touch feedback. | Laboratory automation requires reliable and precise handling of microplates, but existing robotic systems often struggle to achieve this, particularly when navigating around the dynamic and variable nature of laboratory environments. This work introduces a novel method integrating simultaneous localization and mapping ... |
39845376 | The utilisation of biliary organoids for biomedical applications. | Biliary duct injury, biliary atresia (BA), biliary tract tumors, primary sclerosing cholangitis (PSC), and other diseases are commonly encountered in clinical practice within the digestive system. To gain a better understanding of the pathogenesis and development of these diseases and explore more effective treatment m... |
39845031 | Novel target and cofactor repertoire for the transcriptional regulator JTY_0672 from <i>Mycobacterium bovis</i> BCG. | <i>Mycobacterium tuberculosis</i> (Mtb) is the pathogenic agent of tuberculosis (TB). Intracellular survival plays a central role in the pathogenesis of Mtb in a manner that is dependent on an array of transcriptional regulators for Mtb. However, the functionality of JTY_0672, a member of the TetR family of transcripti... |
39840367 | New horizons in smart plant sensors: key technologies, applications, and prospects. | As the source of data acquisition, sensors provide basic data support for crop planting decision management and play a foundational role in developing smart planting. Accurate, stable, and deployable on-site sensors make intelligent monitoring of various planting scenarios possible. Recent breakthroughs in plant advanc... |
39840350 | An autonomous navigation method for orchard mobile robots based on octree 3D point cloud optimization. | Three-dimensional (3D) LiDAR is crucial for the autonomous navigation of orchard mobile robots, offering comprehensive and accurate environmental perception. However, the increased richness of information provided by 3D LiDAR also leads to a higher computational burden for point cloud data processing, posing challenges... |
39840126 | Novel one-step lignin microsphere preparation for oral tissue regeneration applications. | Lignin is a naturally derived biomacromolecule with excellent biocompatibility and the potential for biomedical application. For the first time, this study isolated nanosized lignin microspheres (LMSs) directly from wheat straw with a polyol-based deep eutectic solvent. The size of these LMSs can be regulated by changi... |
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