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39840111 | Gallic acid: a dietary metabolite's therapeutic potential in the management of atherosclerotic cardiovascular disease. | Atherosclerotic cardiovascular disease (ASCVD) causes significant morbidity and mortality globally. Most of the chemicals specifically target certain pathways and minimally impact other diseases associated with ASCVD. Moreover, interactions of these drugs can cause toxic reactions. Consequently, the exploration of mult... |
39840071 | Designing a multi-epitope vaccine candidate against human rhinovirus C utilizing immunoinformatics approach. | Human rhinovirus C (HRV-C) is a significant contributor to respiratory tract infections in children and is implicated in asthma exacerbations across all age groups. Despite its impact, there is currently no licensed vaccine available for HRV-C. Here, we present a novel approach to address this gap by employing immunoin... |
39840069 | Virus-like particle: a nano-platform that delivers cancer antigens to elicit an anti-tumor immune response. | Virus-like particles (VLPs), as a unique form of nanocarrier, predominantly encompass hollow protein shells that exhibit analogous morphology and structure to naturally occurring viruses, yet devoid of genetic material. VLPs are considered safe, easily modifiable, and stable, making them suitable for preparation in var... |
39840043 | PANoptosis in intestinal epithelium: its significance in inflammatory bowel disease and a potential novel therapeutic target for natural products. | The intestinal epithelium, beyond its role in absorption and digestion, serves as a critical protective mechanical barrier that delineates the luminal contents and the gut microbiota from the lamina propria within resident mucosal immune cells to maintain intestinal homeostasis. The barrier is manifested as a contiguou... |
39840036 | Ligands of CD6: roles in the pathogenesis and treatment of cancer. | Cluster of Differentiation 6 (CD6), an established marker of T cells, has multiple and complex functions in regulation of T cell activation and proliferation, and in adhesion of T cells to antigen-presenting cells and epithelial cells in various organs and tissues. Early studies on CD6 demonstrated its role in mediatin... |
39839941 | Comprehensibility of gender-fair language in German-language video lectures. | In many languages, it is common to use masculine-only forms when all genders are meant or gender is irrelevant to the actual statement. This practice is criticized for making women and members of other genders, their achievements and interests, less visible. Gender-fair language is intended to represent all genders equ... |
39839778 | REV7: a small but mighty regulator of genome maintenance and cancer development. | REV7, also known as MAD2B, MAD2L2, and FANCV, is a HORMA-domain family protein crucial to multiple genome stability pathways. REV7's canonical role is as a member of polymerase ζ, a specialized translesion synthesis polymerase essential for DNA damage tolerance. REV7 also ensures accurate cell cycle progression and pre... |
39839637 | Advances in the clinical application of machine learning in acute pancreatitis: a review. | Traditional disease prediction models and scoring systems for acute pancreatitis (AP) are often inadequate in providing concise, reliable, and effective predictions regarding disease progression and prognosis. As a novel interdisciplinary field within artificial intelligence (AI), machine learning (ML) is increasingly ... |
39839278 | Efficacy and safety of Jianpi Qinghua granules for non-erosive reflux disease with spleen deficiency and damp-heat syndrome: a multicenter, randomized, double-blind, placebo-controlled clinical trial. | <h4>Background</h4>Non-erosive reflux disease (NERD), the most frequent phenotype of gastroesophageal reflux disease, presents without visible esophageal mucosal damage but significantly impacts patients' quality of life. Current treatments like proton pump inhibitors show limited efficacy for many NERD patients, neces... |
39839116 | Unveiling the role of BON domain-containing proteins in antibiotic resistance. | The alarming rise of antibiotic-resistant Gram-negative bacteria poses a global health crisis. Their unique outer membrane restricts antibiotic access. While diffusion porins are well-studied, the role of BON domain-containing proteins (BDCPs) in resistance remains unexplored. We analyze protein databases, revealing wi... |
39822905 | <i>In situ</i> synthesis of degradable polymer prodrug nanoparticles. | The <i>in situ</i> synthesis of degradable polymer prodrug nanoparticles is still a challenge to be met, which would make it possible to remedy both the shortcomings of traditional formulation of preformed polymers (<i>e.g.</i>, low nanoparticle concentrations) and those of the physical encapsulation of drugs (<i>e.g.<... |
39811010 | Dibenzyl isophthalates as versatile hosts in room temperature phosphorescence host-guest systems. | We report a series of dibenzyl isophthalates (DBIs) as novel hosts for room-temperature phosphorescence (RTP) host-guest systems, achieving RTP quantum yields (QY) of up to 77% or lifetimes of up to 21.0 s with the guest coronene-<i>d</i> <sub>12</sub>. Furthermore, a 4,4'-Br substituted DBI was used to form host-guest... |
39808916 | JTF-SqueezeNet: A SqueezeNet network based on joint time-frequency data representation for egg-laying detection in individually caged ducks. | Accurate individual egg-laying detection is crucial for eliminating low-yielding breeder ducks and improving production efficiency. However, existing methods are often expensive and require strict environmental conditions. This study proposes a data processing method based on wearable sensors and joint time-frequency r... |
39773561 | Targeted inhibition of Aurora kinase A promotes immune checkpoint inhibition efficacy in human papillomavirus-driven cancers. | <h4>Background</h4>Human papillomavirus (HPV)-driven cancers include head and neck squamous cell carcinoma and cervical cancer and represent approximately 5% of all cancer cases worldwide. Standard-of-care chemotherapy, radiotherapy, and immune checkpoint inhibitors (ICIs) are associated with adverse effects and limite... |
39765416 | Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO. | Extracorporeal membrane oxygenation (ECMO) is a technique used to support severe cardiopulmonary failure. Its potential life-saving benefits are tempered by the significant risk for acute brain injury (ABI), from both primary pathophysiologic factors and ECMO-related complications through central nervous system cellula... |
39765080 | Fe<sub>3</sub>O<sub>4</sub>/Ni nanoparticles anchored nitrogen-doped porous carbon derived from core-shell MOF for simultaneous electrochemical detection of dopamine and 5-hydroxytryptamine. | Pre-designed core-shell metal-organic frameworks (MOFs@MOFs) with customized functionalities can enhance the material properties compared to conventional single MOFs. The porous carbon composites derived from MOFs@MOFs also have excellent functionality due to the presence of multiple metal/metal oxide nanoparticles. Th... |
39764711 | Short Aromatic Blocks Enhance Styrene Conversion in Polymer Cubosome Formation via Polymerization-Induced Self-Assembly. | Polymer cubosomes (PCs) have garnered significant interest in the field of nanomaterials and nanotechnology due to their unique properties and potential applications. However, the fabrication of PCs remains challenging. Polymerization-induced self-assembly (PISA) is recognized as an efficient method for producing a var... |
39764695 | Bis-Naphthylacrylonitrile-Based Supramolecular Artificial Light-Harvesting System for White Light Emission. | A novel aggregation-induced emission (AIE)-based artificial light-harvesting system (LHS) is successfully assembled via the host-guest interaction of bis-naphthylacrylonitrile derivative (BND), water-soluble pillar[5]arene (WP5), and sulforhodamine 101 (SR101). After host-guest assembly, the formed WP5⊃BND complexes sp... |
39763431 | Evaporation-Induced Reticular Growth of UiO-66_NH<sub>2</sub> in Chitosan Films: Adsorption of Iodine. | Metal-organic frameworks (MOFs) combined with polymers as hybrid materials offer numerous advantages such as enhanced performances through synergistic effects at their interface. The primary challenge in developing polymer/MOF hybrid matrix films is ensuring optimal dispersion and strong adhesion of crystalline MOFs to... |
39805241 | Chiral alkynyl Au(I) complexes: Enhancing chiroptical amplification of circularly polarized luminescence through supramolecular helices. | The construction of helical structures through self-assembly and the exploration of their formation mechanisms not only amplify chiroptical properties but also provide profound insights into the structures and functions of natural helices. In this study, we developed a chiral Au(I) system based on BINAP and alkynyl lig... |
39801568 | Real-World Treatment Outcomes of an Artificial Tear Containing Arabinogalactan, Hyaluronic Acid and Trehalose Among Subjects with Dry Eye. | <h4>Purpose</h4>To assess the efficacy, adherence, and tolerability of a new artificial tear based on arabinogalactan, hyaluronic acid, and trehalose in a population with dry eye disease (DED).<h4>Methods</h4>A retrospective, real-world, post-marketing study identified 96 adult patients (aged 18-80 years) with signs an... |
39798417 | Fluorescent distinguishing flavonoid glycosides against aglycones based on the selective recognization of boric acid-functional Eu(III)-organic framework. | Flavonoid glycosides are formed by dehydration condensation of aglycones and sugar molecules. Therefore, discrimination of flavonoid glycosides from their corresponding aglycones is a challenging task because they contain the same aglycone part in their molecular structures. Herein, boric acid-functional Eu(III)-organi... |
39798360 | Enhanced ammonia-sensitive intelligent films based on a metal-organic framework for accurate shrimp freshness monitoring. | Sensitive intelligent films can be used to accurately monitor food freshness. In this study, a cellulose acetate curcumin-loaded cyclodextrin (CD)-based metal-organic framework intelligent film (CA-Cur@CD-MOF) was developed to monitor shrimp freshness at different spoilage stages in real time. The mechanical, barrier, ... |
39788387 | GAS41 promotes ITGA4-mediated PI3K/Akt/mTOR signaling pathway and glioma tumorigenesis. | Glioma Amplified Sequence 41 (GAS41) is a chromatin-associated protein that belongs to the YEATS domain family of proteins and is frequently amplified in various tumors. However, its biological function and carcinogenic mechanism in gliomas are not fully understood. In this study, we revealed that GAS41 was upregulated... |
39781223 | Symmetrical and asymmetrical surface structure expansions of silver nanoclusters with atomic precision. | Controlling symmetrical or asymmetrical growth has allowed a series of novel nanomaterials with prominent physicochemical properties to be produced. However, precise and continuous size growth based on a preserved template has long been a challenging pursuit, yet little has been achieved in terms of manipulation at the... |
39778578 | Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. | The N-Myc transcription factor, encoded by MYCN, is a mechanistically validated, yet challenging, target for neuroblastoma (NB) therapy development. In normal neuronal progenitors, N-Myc undergoes rapid degradation, while, in MYCN-amplified NB cells, Aurora kinase A (Aurora-A) binds to and stabilizes N-Myc, resulting i... |
39778492 | Highly hydrophobic calixarene polymers for efficient enrichment of polar nitrobenzene compounds. | Macrocyclic polymer materials exhibit excellent selectivity and adsorption performance in pollutant adsorption due to unique host-guest recognition. Herein, three kinds of calixarene polymers (C4P, C6P and C8P) were synthesized through Sonogashira reaction, and were characterized through <sup>1</sup>H NMR, FT-IR, SEM, ... |
39778387 | Synthetic peptide scaffolds as ion channels and molecular carriers. | Transmembrane ion exchange controls biological functions and is essential for life. Over the years, a great variety of nature-inspired artificial ion channels and carriers have been synthesized to control and promote ion exchange across biological membranes. In this context, peptides emerged as ideal scaffolds for synt... |
39778074 | Substituent-Driven Anion-Binding Selectivity in Aliphatic Chain-Substituted 1,2-Phenylene Urea Macrocycles and Optimized Synthetic Methodology. | 1,2-Phenylene tetraurea macrocycles recently attracted attention as self-assembled channel-making compounds with high selectivity to chlorides. Here, we report on the introduction of aliphatic chains in the periphery of the 1,2-phenylene tetraurea macrocycle, which led to deterioration in the ability of the macrocycle ... |
39778059 | Ultrafast, Robust, and Reversible Self-Assembled Nanofibers via Thiolactone Chemistry Strategy. | Self-assembly in supramolecular chemistry is crucial for nanostructure creation but faces challenges like slow speeds and lack of reversibility. In this study, a novel comb-like polymer poly(amide sulfide) (PAS) based on thiolactone chemistry is reported, which rapidly self-assemble into stable nanofibers, offering exc... |
39778018 | Conductive Hydrogel Systems Enabling Rapid and Controllable Release of Guests at Low-Voltage Region. | Smart delivery materials that respond to electric fields attract interest across various fields, whereas systems enabling rapid, controllable, and safe delivery capabilities remain essential. Based on the hypothesis of utilizing electric field to manipulate inter-component noncovalent bonds in delivery materials, a hyd... |
39777982 | Surface Engineering of 2D Metal-Porphyrin Metal-Organic Frameworks Z-Scheme Heterostructure for Boosting and Stable Photocatalytic Hydrogen Evolution. | How to improve the stability and activity of metal-organic frameworks is an attractive but challenging task in energy conversion and pollutant degradation of metal-organic framework materials. In this paper, a facile method is developed by fabricating titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) layer on 2D cop... |
39777922 | Synthetic Aspects and Characterization Needs in MOF Chemistry - from Discovery to Applications. | Even if MOFs are recently developed for large-scale applications, the road to applications of MOFs is long and rocky. This requires to overcome challenges associated with phase discovery, synthesis optimization, basic and advanced characterization, and computational studies. Lab-scale results need to be transferred to ... |
39777914 | CO<sub>2</sub> and Temperature Induced Switching of a Flexible Metal-Organic Framework with Surface-Mounted Nanoparticles. | Within the material family of metal-organic frameworks (MOFs) the subclass of flexible MOFs (flexMOFs) has attracted great attention, showing structural flexibility as a response to external stimuli such as guest adsorption, temperature, and pressure. Hybrid composites like nanoparticle (NP) loaded flexible MOFs, which... |
39777895 | Tailoring Super-Performed Chemo-Sensor via Simulation-Modeling and MEMS-Screening. | Chemo-sensor designing involves a time-consuming trial-and-error screening process, which commonly cannot lead to optimal S<sup>4</sup>R features (Sensitivity, Selectivity, Speed, Stability, and Reversibility). Due to strong path dependence on reported groups/mechanisms, conventional chemo-sensors often fail to meet cr... |
39777863 | Engineered 3D DNA Crystals: A Molecular Design Perspective. | Recent advances in biomolecular self-assembly have transformed material science, enabling the creation of novel materials with unparalleled precision and functionality. Among these innovations, 3D DNA crystals have emerged as a distinctive class of macroscopic materials, engineered through the bottom-up approach by DNA... |
39777860 | Comparative bioactivity analysis of latex and water extract of Euphorbia gaillardotii: chemical profile, antioxidant capacity, effects on water quality, in vitro antimicrobial-cytotoxic activities, and in silico molecular docking studies. | The genus Euphorbia, belonging to the family Euphorbiaceae, represents a significant ethnobotanical heritage due to the diverse bioactive properties exhibited. In this study, the phytochemical composition and biological activities of latex and aerial parts of the water extract of Euphorbia gaillardotii were investigate... |
39777803 | Wood and Cellulose: the Most Sustainable Advanced Materials for Past, Present, and Future Civilizations. | Wood, with its constituent building block cellulose, is by far the most common biomaterial on the planet and has been the most important material used by humans to establish civilization. If there is one single biomaterial that should be studied and used by materials scientists across disciplines to achieve a sustainab... |
39777433 | Recent Advances and Perspectives on Coupled Water Electrolysis for Energy-Saving Hydrogen Production. | Overall water splitting (OWS) to produce hydrogen has attracted large attention in recent years due to its ecological-friendliness and sustainability. However, the efficiency of OWS has been forced by the sluggish kinetics of the four-electron oxygen evolution reaction (OER). The replacement of OER by alternative elect... |
39776280 | Deciphering the Role of Second Metal in M-Ni (M = Fe, Ni, and Mn) Heterobimetallic Electrocatalysts in Controlling the HAT versus Hydride Transfer Mechanism for the Dehydrogenation of Alcohols. | The second 3d-transition metal incorporation in Ni-(oxy)hydroxide has a drastic effect on alkaline OER and alcohol dehydrogenation reactivity. While Mn incorporation suppresses the alkaline OER, it greatly improves the alcohol dehydrogenation reactivity. A complete reversal of reactivity is obtained when Fe is incorpor... |
39775168 | FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains. | O-Fucosylation plays crucial roles in various essential biological events. Alongside the well-established O-fucosylation of epidermal growth factor-like repeats by protein O-fucosyltransferase 1 (POFUT1) and thrombospondin type 1 repeats by POFUT2, we recently identified a type of O-fucosylation on the elastin microfib... |
39775135 | Comparative transcriptome analyses of different orthosiphon aristatus tissues reveal differentially expressed genes associated with flavonoid biosynthesis. | Orthosiphon aristatus (O. aristatus) has been used as a popular traditional folk medicine for the treatment of kidney disease. Recent studies have shown that O. aristatus root contains more flavonoids and has higher antioxidant capacity compared to its medicinal parts. However, there is limited knowledge on the mechani... |
39775102 | Acceptor engineering of quinone-based cycloparaphenylenes via post-synthesis for achieving white-light emission in single-molecule. | Developing donor-acceptor [n]cycloparaphenylenes (D-A [n]CPPs) with multiple emissions from different emissive states remains challenging yet crucial for achieving white-light emission in single-molecule. Here, we report our explorations into acceptor engineering of quinone-based D-A [10]CPPs (Nq/Aq/Tq[10]CPPs) via a p... |
39775076 | External validation of an artificial intelligence model using clinical variables, including ICD-10 codes, for predicting in-hospital mortality among trauma patients: a multicenter retrospective cohort study. | Artificial intelligence (AI) is being increasingly applied in healthcare to improve patient care and clinical outcomes. We previously developed an AI model using ICD-10 (International Classification of Diseases, Tenth Revision) codes with other clinical variables to predict in-hospital mortality among trauma patients f... |
39774985 | Ln-MOF in production of durable antimicrobial and UV-Protective fluorescent cotton fabric for potential application in military textiles. | Industrialization of military textiles faces many challenges and some requirements such as durability, protection and suitability for hostile environment must be provided. Herein, fluorescent protective cotton with ultraviolet radiation (UVR)-protection and antimicrobial property was currently prepared via the immobili... |
39774954 | BrCF<sub>2</sub>CN for photocatalytic cyanodifluoromethylation. | Considering the unique electronic properties of the CF<sub>2</sub> and the CN groups, the CF<sub>2</sub>CN group has significant potential in drug and agrochemical development, as well as material sciences. However, incorporating a CF<sub>2</sub>CN group remains a considerable challenge. In this work, we disclose a use... |
39774546 | Integrative metabolomics and transcriptomics profiling reveals differential expression of flavonoid synthesis in Ophiopogon japonicus (L. f.) Ker-Gawl. in adaptation to drought. | Drought is one of the consequences of climate change that severely affects plant growth and development. Ophiopogon japonicus (L. f.) Ker-Gawl. (Chinese name: Chuanmaidong, abbreviated as CMD) is a commonly used herbaceous plant whose growth and development are strongly affected by drought. Here, we comprehensively ana... |
39774464 | Cross-species recognition of two porcine coronaviruses to their cellular receptor aminopeptidase N of dogs and seven other species. | Porcine deltacoronavirus (PDCoV) and transmissible gastroenteritis coronavirus (TGEV), the two causative agents of porcine diarrhea, have been reported to be at risk of cross-species transmission, including to humans. However, the potential host range in which these two CoVs interact remains unclear. We screened 16 ani... |
39774260 | Roles of immunoglobulin GM and KM allotypes and Fcγ receptor 2 A genotypes in humoral immunity to a conserved microbial polysaccharide in pulmonary diseases. | Immunoglobulin GM (γ marker) and KM (κ marker) allotypes-encoded by immunoglobulin heavy chain G (IGHG) and immunoglobulin κ constant (IGKC) genes-have been shown to be associated with immune responsiveness to a variety of self and nonself antigens. The aim of the present investigation was to determine whether allelic ... |
39774136 | Defluorinative functionalization approach led by difluoromethyl anion chemistry. | Organofluorine compounds have greatly benefited the pharmaceutical, agrochemical, and materials sectors. However, they are plagued by concerns associated with Per- and Polyfluoroalkyl Substances. Additionally, the widespread use of the trifluoromethyl group is facing imminent regulatory scrutiny. Defluorinative functio... |
39774022 | Mechanistic insights into gut microbe derived siderophores and PHD2 interactions with implications for HIF-1α stabilization. | In oxygen-deprived conditions, cells respond by activating adaptive mechanisms to bolster their survival and protect tissue integrity. A key player in this process is the HIF-1α signaling cascade, meticulously regulated by Prolyl Hydroxylase Domain 2 (PHD2), which orchestrates cellular responses to varying oxygen level... |
39773984 | Endothelial-secreted Endocan activates PDGFRA and regulates vascularity and spatial phenotype in glioblastoma. | Extensive neovascularization is a hallmark of glioblastoma (GBM). In addition to supplying oxygen and nutrients, vascular endothelial cells provide trophic support to GBM cells via paracrine signaling. Here we report that Endocan (ESM1), an endothelial-secreted proteoglycan, confers enhanced proliferative, migratory, a... |
39773525 | Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease. | The SARS-CoV-2 main protease (M<sup>pro</sup> or Nsp5) is critical for production of viral proteins during infection and, like many viral proteases, also targets host proteins to subvert their cellular functions. Here, we show that the human tRNA methyltransferase TRMT1 is recognized and cleaved by SARS-CoV-2 M<sup>pro... |
39773020 | Transcriptome integration analysis revealed that miR-103-3p regulates goat myoblast proliferation by targeting FGF18. | <h4>Background</h4>Myoblasts serve as the fundamental building blocks of muscle fibers, and there is a positive correlation between the diameter of myofibers during the juvenile phase and the rate of muscle growth, which does not change in adulthood. However, the molecular mechanisms governing myofiber diameter across ... |
39772746 | Synthesis of ethane from CO<sub>2</sub> by a methyl transferase-inspired molecular catalyst. | Molecular catalysts with a single metal center are reported to reduce CO<sub>2</sub> to a wide range of valuable single-carbon products like CO, HCOOH, CH<sub>3</sub>OH, etc. However, these catalysts cannot reduce CO<sub>2</sub> to two carbon products like ethane or ethylene and the ability to form C-C from CO<sub>2</s... |
39772658 | Screening Cyclodextrin Complexes for Bisphenols with High Binding Performance Based on the Data-Driven Model. | The distinctive cavity structure of cyclodextrin, which results in binding properties, is credited with its application prospects in chemical, pharmacy, and material fields. The binding capacity can be regulated by substituting the hydroxyl groups on the cyclodextrins. It is possible to acquire anticipated binding prop... |
39772649 | Stability and Properties of Ultraviolet Filter Avobenzone under Its Diketo/Enol Tautomerization Induced by Molecular Encapsulation with β-Cyclodextrin. | Inclusion complexation of the sunscreen ingredient avobenzone (AVB) with β-cyclodextrin (β-CD) was investigated to improve its aqueous solubility and photostability; another ultraviolet (UV) filter, oxybenzone (OXB), and the phytochemical antioxidant curcumin (CUR) served as a comparison. In this study, the 1-octanol/w... |
39772554 | Mechanical Twisting-Induced Enhancement of Second-Order Optical Nonlinearity in a Flexible Molecular Crystal. | Flexible molecular crystals are essential for advancing smart materials, providing unique functionality and adaptability for applications in next-generation electronics, pharmaceuticals, and energy storage. However, the optical applications of flexible molecular crystals have been largely restricted to linear optics, w... |
39772529 | DNA Self-Assembly Generated by Aptamer-Triggered Rolling Circle Amplification Cascades for Profiling Colorectal Cancer-Derived Small Extracellular Vesicles. | The analysis of small extracellular vesicles (sEVs) has shown clinical significance in early cancer diagnostics and considerable potential in prognostic assessment and therapeutic monitoring, offering possibilities for precise clinical intervention. Despite recent diagnostic progress based on blood-derived sEVs, the in... |
39772501 | No Bridge between Us: EXAFS and Computations Confirm Two Distant Iron Ions Comprise the Active Site of Alkane Monooxygenase (AlkB). | Alkane monooxygenase (AlkB) is the dominant enzyme that catalyzes the oxidation of liquid alkanes in the environment. Two recent structural models derived from cryo-electron microscopy (cryo-EM) reveal an unusual active site: a histidine-rich center that binds two iron ions without a bridging ligand. To ensure that pot... |
39772494 | Isolation of Inner-Sphere Aquo Complexes of Samarium(II). | The <i>cis-anti-cis</i> and <i>cis-syn-cis</i> isomers of [Sm(dicyclohexano-18-crown-6)(H<sub>2</sub>O)<sub>2</sub>]I<sub>2</sub> exhibiting <i>trans</i> water molecules bound to the Sm<sup>2+</sup> ion have been isolated and characterized. Sm<sup>2+</sup> possesses an electrochemical potential sufficient for water red... |
39772462 | Light-/pH-Regulated Spiropyran Smart-Responsive Hydrophilic Separation Platform for the Identification of Serum Glycopeptides from Hepatocellular Carcinoma Patients. | Smart-responsive materials have attracted much attention in the enrichment of post-translational modifications of proteins. In this work, for the first time, we developed a smart enrichment strategy (MNPs-l-DOPA/PEI-SP) based on the change in hydrophilic properties of spiropyran under the regulation of light and pH to ... |
39772461 | Unlocking the Antibacterial Potential of Naphthalimide-Coumarins to Overcome Drug Resistance with Antibiofilm and Membrane Disruption Ability against <i>Escherichia coli</i>. | Resistance by bacteria to available antibiotics is a threat to human health, which demands the development of new antibacterial agents. Considering the prevailing conditions, we have developed a library of new naphthalimide-coumarin moieties as broad-spectrum antibacterial agents to fight against awful drug resistance.... |
39772455 | Calixarene-Based Magnetic Nanosponge Decorating AgNPs for Rapid and Selective Surface-Enhanced Raman Scattering Analysis in Complex Samples. | Rapid and accurate analysis of trace targets in complex samples remains an enormous challenge. Herein, the calix[<i>x</i>]arene-based magnetic cross-linked polymer decorating AgNPs, abbreviated Fe<sub>3</sub>O<sub>4</sub>-CXA-DAB@AgNPs nanosponge, was developed for fast surface-enhanced Raman scattering (SERS) analysis... |
39772451 | Tripodal Triptycenes as a Versatile Building Block for Highly Ordered Molecular Films and Self-Assembled Monolayers. | ConspectusThe design of properties and functions of molecular assemblies requires not only a proper choice of building blocks but also control over their packing arrangements. A highly versatile unit in this context is a particular type of triptycene with substituents at the 1,8,13-positions, called tripodal triptycene... |
39772439 | Polarity Sensor Based on Multivariate Lanthanide Metal-Organic Framework for Constructing Biosensing Platform. | It is significant but challenging to develop polarity sensors that can measure multiscenario polarity in a modular, customized, sensitive, and accurate manner. In this work, we proposed a polarity sensor based on multivariate lanthanide metal-organic framework (Ln-MOF) nanoclusters through the modular programming desig... |
39772434 | Curcumin-Loaded Maltodextrin-Based Proniosomes Potentially Effective against Gemcitabine-Resistant Cholangiocarcinoma. | Cholangiocarcinoma (CCA) or bile-duct cancer is most prevalent in Southeast Asian counties including Thailand. Patients present at an advanced stage when the cancer is often drug resistant, leading to chemotherapy failure. Curcumin has therapeutic potential with various anticancer properties. However, its effectiveness... |
39772435 | K<sup>+</sup>-Responsive Nanoparticles with Charge Reversal and Gating Synergistic Effects for Targeted Intracellular Bacteria Eradication. | Intracellular bacteria can evade the attack of the immune system and the bactericidal effects of most antibiotics due to the protective effect of the host cells. Herein, inspired by the stimuli-responsive behaviors of biological ion channels, a kind of synergistic cascade potassium ion (K<sup>+</sup>)-responsive nanopa... |
39772428 | Two-Component Hydrogels Built from Chinese Herbal Medicine-Derived Glycyrrhizic Acid and Puerarin: Assembly Mechanism, Self-Healing Properties, and Selective Antibacterial Activity. | Chinese herbal medicine has offered a great treasure for discovering intrinsically bioactive low molecular weight gelators (LMWGs). Herein, the two-component hydrogels comprising glycyrrhizic acid (GA) and puerarin (PUE), the primary bioactive components, respectively, from herbs <i>Glycyrrhiza uralensis</i> <i>Fisch</... |
39772410 | Developing a Novel Agrochemical-Based MOF: A Multifunctional Platform with Herbicidal and Antibacterial Activities. | Excessive and uncontrolled application of agrochemicals has resulted in contamination of terrestrial and aquatic environments. In the past decade, metal-organic frameworks (MOFs) have been studied as agrochemical release systems to enhance efficiency while reducing the leaching of toxic molecules to the environment. In... |
39762538 | Exploring the interactions of rapamycin with target receptors in A549 cancer cells: insights from molecular docking analysis. | Rapamycin, a macrocyclic antibiotic derived from the actinomycetes Streptomyces hygroscopicus, is a widely used immunosuppressant and anticancer drug. Even though rapamycin is regarded as a multipotent drug acting against a broad array of anomalies and diseases, the mechanism of action of rapamycin and associated pathw... |
39714899 | Hybrid Inclusion Materials Based on Chiral Nematic Mesoporous Organosilica with Incorporated Cyclodextrin Receptors. | The creation of multicomponent materials with desired properties and functions is a challenge of modern materials chemistry. Chiral nematic mesoporous organosilicas have iridescent properties that make them attractive for decoration and sensing. In this paper, we demonstrate the chemical functionalization of chiral nem... |
39714825 | Block Architectures in 2D Polymer Networks Fabricated via Sequential Copolymerization in a Metal-Organic Framework. | Two-dimensional (2D) polymer network monolayers with novel block architectures were fabricated via sequential copolymerization within a pillared-layer metal-organic framework (MOF) that served as the reaction template. The MOF provides a confined 2D nanospace, restricting the crosslinking copolymerization of vinyl mono... |
39714440 | Polyurethane Elastomers Strengthened by Pseudo[1]rotaxanes Based on Pillararenes. | As a unique property of the interlocked structures, rotaxane allows for intramolecular motions between its wheel and axle components. Introduction of rotaxanes into polymers can endow them with distinctive macroscopic features and outstanding mechanical properties. Here, we prepare a copillar[5]arene with a hydroxyl an... |
39714431 | Arraying and Guest Inclusion of Soluble Metal-Organic Nanotubes Composed of Macrocyclic Paddle-Wheel Metal Complexes. | A new series of metal-organic nanotubes was constructed through one-dimensional assembly using molecular triangles or molecular squares composed of paddlewheel dirhodium complexes and bidentate axial ligands. The metal-organic nanotubes were significantly different from conventional solid metal-organic framework (MOF) ... |
39714422 | Imperfections Immobilization and Regeneration in Perovskite with Redox-Active Supramolecular Assembly for Stable Solar Cells. | Imperfections in metal halide perovskites, such as those induced by light exposure or thermal stress, compromise device performance and stability. A key challenge is immobilizing volatile iodine produced by iodide oxidation and regenerating impurities like elemental lead and iodine. Here, we address this by integrating... |
39714418 | Chalcogen Bonding Catalysis Enables Ring-Opening of Cyclopropene and Ring Expansion of Aryl Ketones. | Catalytic transformation of carbene species constitutes a fundamental part in organic synthesis, and the research in this direction has been dominated by transition metals while organic catalysts are difficult to mimic such transition-metal-like reactivity. It would significantly advance carbene chemistry if organic ca... |
39714401 | Stimuli-Responsive DNA Nanomachines for Intracellular Targeted Electrochemiluminescence Imaging in Single Cells. | Electrochemiluminescence (ECL) microscopy has emerged as a powerful technique for single-cell imaging owing to its unparalleled background-free imaging advantages. However, controlled intracellular ECL imaging remains challenging. Here, we developed a stimuli-responsive self-assembled DNA nanomachine that enables the E... |
39714400 | In Vivo Self-Assembly of PROTACs by Bioorthogonal Chemistry for Precision Cancer Therapy. | Proteolysis targeting chimeras (PROTACs) hold immense promise for targeted protein degradation; however, challenges such as off-target effects, poor drug-likeness properties, and the "hook effect" remain. This study introduces Nano-Click-formed PROTACs (Nano-CLIPTACs) for precise tumor protein degradation in vivo. Trad... |
39714346 | Isomerization-Controlled Aggregation in Photoactive Layer: An Additive Strategy for Organic Solar Cells with Over 19.5 % Efficiency. | Morphology control of the photoactive layer is crucial for achieving high-performance organic solar cells (OSCs), yet it remains a significant challenge in this field. One effective approach is the additive strategy, which fine-tunes the morphology of the photoactive layer. However, the underlying mechanisms governing ... |
39688221 | Inter- and Intra-Molecular Charge Redistributions in H-Bonded Cyanuric Acid*Melamine (CA*M) Networks: Insight From Core Level Spectroscopy and Natural Bond Orbital Analysis. | In this work, we elucidate the electronic charge redistributions that occur within the cyanuric acid (CA) and melamine (M) molecules upon formation of the triple H-bond between the imide group of CA and the diaminopyridine group of M. To achieve this, we investigated 2D H-bonded assemblies of M, CA and CA*M grown on th... |
39660419 | TPDYs: strained macrocyclic diynes for bioconjugation processes. | A terphenyl diyne (TPDY) macrocycle, 3,5-TPDY, has been developed incorporating a bent 1,3-diyne that is active in SPAAC processes affording atropoisomeric triazole products, as well as cycloadditions with diazoacetates and tetrazines. A pendant amine allowed bioconjugation of TPDY to two proteins in a microbial transg... |
39660367 | A self-assembled metallo-macrocycle two-qubit spin system. | A self-assembled, charge-neutral dicopper(II) metallo-macrocycle with a near degenerate singlet-triplet ground state is a prototype molecular two-qubit system. The weakly-coupled spin centres delivered a long phase memory time of 5.4 μs, and each spin can be selectively switched using an applied potential providing a c... |
39655486 | Macrocyclic catalysis mediated by water: opportunities and challenges. | Nanospaces within enzymes play a crucial role in chemical reactions in biological systems, garnering significant attention from supramolecular chemists. Inspired by the highly efficient catalysis of enzymes, artificial supramolecular hosts have been developed and widely employed in various reactions, paving the way for... |
40678412 | Discovery and characterization of selective lipase-inhibiting polyheterocyclic derivatives: a combined in silico and in vitro study. | <h4>Background/aim</h4>Obesity has become a global health crisis with an increasing prevalence, necessitating the search for effective therapies. Schiff base derivatives, known for their broad pharmacological activities, have gained attention as potential antiobesity agents. This study aimed to investigate the lipase i... |
40196341 | Innovative composite systems for enhancing plant polyphenol stability and bioavailability. | Plant polyphenols, secondary metabolites in plants, possess valuable functional properties, including anti-inflammatory, antioxidative, and hypoglycemic effects. However, their application in food products is often limited by chemical instability. This review examines innovative composite delivery systems designed to e... |
40182019 | A guide to selecting high-performing antibodies for TAF15 (UniProt ID: Q92804) for use in western blot, immunoprecipitation, and immunofluorescence. | TAF15 (TATA-box binding protein-associated factor 15) is a member of the FET protein family, known for their roles in transcriptional regulation and RNA metabolism. Here we have characterized five TAF15 commercial antibodies for western blot, immunoprecipitation, and immunofluorescence using a standardized experimental... |
40160946 | Improved Skill of Rotaxanes to Recognize Cations: A Theoretical Perspective. | Cations have significant applications in fields such as medicinal inorganic chemistry and catalysis. Rotaxanes are composed of a macrocyclic structure that is mechanically interlocked with a linear molecule. These mechanically interlocked molecules (MIMs) provide a potential chemical environment that allows for the int... |
40115375 | Mitochondria-targeting nanomedicines with autophagy inhibitor to enhance cancer photothermal-chemotherapy. | In this article, we fabricated nanomedicines with mitochondrial targeting function and autophagy inhibitor for enhancing cancer photothermal-chemotherapy. The nanoparticles were fabricated with gold nanoparticles (AuNPs) as cores and amphiphilic dextran with (3-carboxypropyl) triphenyl phosphorus bromide and β-cyclodex... |
39983449 | Architects of infection: A structural overview of SARS-related coronavirus spike glycoproteins. | The frequency of zoonotic viral emergence within the Coronaviridae family highlights the critical need to understand the structural features of spike proteins that govern viral entry and host adaptation. Investigating the structural conservation and variation in key regions of the spike protein-those involved in host r... |
39974639 | A Comprehensive Review of Current Approaches in Bladder Cancer Treatment. | Bladder cancer is one of the most common malignant tumors of the urinary system globally. It is also one of the most expensive cancers to manage, due to the need for extensive treatment and follow-ups that often involve invasive and costly procedures. Although there have been some improvements in treatment options, the... |
39931187 | Fast water transport and ionic sieving in ultrathin stacked nanoporous 2D membranes. | Atomically thin nanoporous 2D membranes, featuring unique sieving characteristics for molecules and ions, have significant potential for seawater desalination. However, they face a common trade-off between permeability and selectivity. Here, we report an ultrathin stacked nanoporous graphene membrane (SNGM) created by ... |
39925438 | Recyclable adsorbents of Fe and La co-modified clam shells for phosphorus removal from domestic sewage: Characterization and mechanisms. | This research focused on creating a recyclable magnetic adsorbent, termed La@Fe-CCS, which was modified with lanthanum (La) to improve its efficiency in removing phosphate. The process involved integrating lanthanum into an iron (Fe)-based clam shell matrix (Fe-CCS). This study showed that La@Fe-CCS demonstrated superi... |
39897558 | Tumor-selective dye-based histological electrophoresis enables intraoperative tumor diagnosis via tumor-specific enhancement. | Solid tissue biopsy is fundamental in guiding surgeons during intraoperative and peri-operative management of cancer patients. However, conventional histopathologic methods depend heavily on the expertise of trained pathologists, facing challenges in accuracy and efficiency. <b>Methods:</b> Here, we show that unbiased ... |
39897545 | Single-cell nanocapsules of gut microbiota facilitate fecal microbiota transplantation. | <b>Rationale:</b> Fecal microbiota transplantation (FMT) is advantageous for treating intractable diseases via the microbiota-gut-organ axis. However, invasive administration of gut microbiota via nasal feeding tubes limits the widespread application of FMT. Here, we attempted to develop a novel strategy to deliver gut... |
39897036 | Immunosenescence, Physical Exercise, and their Implications in Tumor Immunity and Immunotherapy. | Aging is associated with a decline in immune function, termed immunosenescence, which compromises host defences and increases susceptibility to infections and cancer. Physical exercise is widely recognized for its myriad health benefits, including the potential to modulate the immune system. This review explores the bi... |
39886596 | Quantitative Prediction of Protein-Polyelectrolyte Binding Thermodynamics: Adsorption of Heparin-Analog Polysulfates to the SARS-CoV-2 Spike Protein RBD. | Interactions of polyelectrolytes (PEs) with proteins play a crucial role in numerous biological processes, such as the internalization of virus particles into host cells. Although docking, machine learning methods, and molecular dynamics (MD) simulations are utilized to estimate binding poses and binding free energies ... |
39866791 | A novel nanocarrier based on natural polyphenols enhancing gemcitabine sensitization ability for improved pancreatic cancer therapy efficiency. | Pancreatic cancer (PC) is a highly lethal malignancy with rapid progression and poor prognosis. Despite the widespread use of gemcitabine (Gem)-based chemotherapy as the first-line treatment for PC, its efficacy is often compromised by significant drug resistance. 1,2,3,4,6-Pentagaloyl glucose (PGG), a natural polyphen... |
39861857 | Impact of COVID-19 on Ocular Surface Health: Infection Mechanisms, Immune Modulation, and Inflammatory Responses. | COVID-19, caused by SARS-CoV-2, has presented formidable challenges to global health since its emergence in late 2019. While primarily known for respiratory symptoms, it can also affect the ocular surface. This review summarizes the effects of SARS-CoV-2 on ocular surface immunity and inflammation, focusing on infectio... |
39861716 | Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy. | Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited drug loading capacity, and concerns regarding potential toxicity... |
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