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39861119 | The Potential Application of Nanocarriers in Delivering Topical Antioxidants. | The imbalance in the production of reactive oxygen species (ROS) with endogenous antioxidant capacity leads to oxidative stress, which drives many disorders, especially in the skin. In such conditions, supplementing exogenous antioxidants may help the body prevent the negative effect of ROS. However, the skin, as the o... |
39857391 | GENI as an AMPK Activator Binds α and γ Subunits and Improves the Memory Dysfunction of Alzheimer's Disease Mouse Models via Autophagy and Neuroprotection. | Geniposidic 4-isoamyl ester (GENI) with anti-aging effects is a new iridoid glycoside derivative from <i>Gardenia jasminoides</i> Ellis found in our previous study. In this study, to indicate whether this compound has anti-Alzheimer's disease (AD) effect, the galactose-induced AD mice and naturally aging mice with AD w... |
39852571 | From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery. | Biomimetic nanodrug delivery systems based on cell membranes have emerged as a promising approach for targeted cancer therapy due to their biocompatibility and low immunogenicity. Among them, platelet-mediated systems are particularly noteworthy for their innate tumor-homing and cancer cell interaction capabilities. Th... |
39846690 | Evaluation of Drug-Polymer and Drug-Drug Interaction in Cellulosic Multi-Drug Delivery Matrices. | Multi-drug delivery systems have gained increasing interest from the pharmaceutical industry. Alongside this is the interest in amorphous solid dispersions as an approach to achieve effective oral delivery of compounds with solubility-limited bioavailability. Despite this, there is limited information regarding predict... |
39835200 | Characterization of the ligand-binding properties of odorant-binding protein 38 from <i>Riptortus pedestris</i> when interacting with soybean volatiles. | <h4>Background</h4><i>Riptortus pedestris</i> (Fabricius) (Hemiptera: Alydidae) is a major soybean pest throughout East Asia that relies on its advanced olfactory system for the perception of plant-derived volatile compounds and aggregation pheromones for conspecific and host plant localization. Odorant binding protein... |
39834849 | Pectin obtention from agroindustrial wastes of <i>Malus domestica</i> using green solvents (citric acid and natural deep eutectic solvents). Chemical, thermal, and rheological characterization. | The use of green solvents, citric acid (CA), and natural deep eutectic solvents (NADES) for the obtention of pectin from wastes (pulp and peel) of <i>Malus domestica</i> was studied. The NADES used comprised citric acid-glucose-water (N1) or lactic acid-glucose-water (N2). The fractions rich in pectin obtained after ex... |
39834835 | Applications of polymeric nanoparticles in drug delivery for glioblastoma. | Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, necessitating innovative therapeutic approaches. Polymer-based nanotechnology has emerged as a promising solution, offering precise drug delivery, enhanced blood-brain barrier (BBB) penetration, and adaptability to the tumor mic... |
39834832 | Polymer-based antimicrobial strategies for periodontitis. | Periodontitis is a chronic inflammatory condition driven by plaque-associated microorganisms, where uncontrolled bacterial invasion and proliferation impair host immune responses, leading to localized periodontal tissue inflammation and bone destruction. Conventional periodontal therapies face challenges, including inc... |
39834829 | Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations. | The natural world is a vast reservoir of exceptionally varied and inventive chemical compositions. Natural products are used as initial compounds to create combinatorial libraries by targeted modifications and then by analyzing their structure-activity connections. This stage is regarded as a crucial milestone in drug ... |
39834812 | Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development. | Plant- and marine-derived natural products are rich sources of bioactive compounds essential for drug discovery. These compounds contain complex mixtures of metabolites, which collectively contribute to their pharmacological properties. However, challenges arise in the isolation of individual bioactive compounds, owing... |
39834705 | Effects of cattle manure and sludge vermicompost on nutrient dynamics and yield in strawberry cultivation with distinct continuous cropping histories in a greenhouse. | Continuous cropping has emerged as a significant challenge affecting yield and quality in greenhouse strawberries, particularly as the cultivation of strawberries as a protected crop continues to increase. To address this issue, substrates with 0 or 2 years of continuous cropping were fertilized with two types of organ... |
39834655 | <i>In silico</i> identification of chilli genome encoded MicroRNAs targeting the 16S rRNA and <i>secA</i> genes of "<i>Candidatus</i> phytoplasma trifolii<i>"</i>. | Phytoplasma, a potentially hazardous pathogen associated with witches' broom, is an economically harmful disease-producing bacteria that damages chilli cultivation. Phytoplasma-infected plants display various symptoms that indicate significant disruptions in normal plant physiology and behaviour. Diseases caused by phy... |
39834642 | Optogenetic control of mitochondrial aggregation and function. | The balance of mitochondrial fission and fusion plays an important role in maintaining the stability of cellular homeostasis. Abnormal mitochondrial fission and fragmentation have been shown to be associated with oxidative stress, which causes a variety of human diseases from neurodegeneration disease to cancer. Theref... |
39834632 | Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury. | Traumatic brain injury (TBI) represents a significant global public health issue, with effective management posing numerous challenges. The pathophysiology of TBI is typically categorized into two phases: primary and secondary injuries. Secondary injury involves pathophysiological mechanisms such as blood-brain barrier... |
39834388 | Curcumin encapsulated in PAMAM dendrimers for the therapeutic treatment of ischemic stroke in rats. | <h4>Introduction</h4>Ischemic stroke is a devastating neurovascular condition that occurs when cerebral tissue fails to receive an adequate supply of oxygen. Despite being a leading cause of death and disability worldwide, therapeutic interventions are currently limited. Polyamidoamine (PAMAM) dendrimers are nanomolecu... |
39834373 | The response of soil microbial community to application of organic amendment to saline land. | <h4>Introduction</h4>The salinization of coastal soils is a primary cause of global land degradation. The aim of this study was to evaluate the effect of organic amendment on the soil microbial community within a saline gradient.<h4>Methods</h4>The study was designed with five levels of electrical conductivity (EC): 0.... |
39834360 | Gut microbiota: a novel target for exercise-mediated regulation of NLRP3 inflammasome activation. | The NOD-like receptor family pyrin domain-containing 3 (NLRP3) is a key pattern recognition receptor in the innate immune system. Its overactivation leads to the production of pro-inflammatory cytokines, such as IL-1β and IL-18, which contribute to the development and progression of various diseases. In recent years, e... |
39831155 | Enhancing molecular oxygen activation by nitrogen-doped carbon encapsulating FeNi alloys with ultra-low Pt loading. | Modulating the electronic structure of noble metals via electronic metal-support interaction (EMSI) has been proven effectively for facilitating molecular oxygen activation and catalytic oxidation reactions. Nevertheless, the investigation of the fundamental mechanisms underlying activity enhancement has primarily focu... |
39829525 | Optimizing the Construction and Activation of 3D-Printed Electrochemical Sensors: An Experimental Design Approach for Simultaneous Electroanalysis of Paracetamol and Caffeine. | This work presents an optimization of the construction, treatment, and activation of 3D-printed electrochemical sensors (E-3D). For this, was used a 2<sup>3</sup>-full factorial design examining three key variables at two levels: electrode height, electrode diameter, and printing speed. Moreover, it evaluates various p... |
39817987 | Developmental changes of skin quality from breast, back, and thigh of Pekin ducks from 1 to 6 weeks of age. | Good skin quality not only improved carcass quality but also increased consumer demand for fresh poultry meat. This study aimed to investigate the developmental changes in skin growth and quality of Pekin ducks during 1-6 weeks of age. The skin samples were collected from the breast, back, and thigh tissues of six male... |
39817270 | Identification and Characterization of a Protease Producing <i>Bacillus cereus</i> Strain From Tannery Waste for Efficient Dehairing of Goat Skin. | Environmental pollution has been a significant concern for the last few years. The leather industry significantly contributes to the economy but is one of Bangladesh's most prominent polluting industries. It is also responsible for several severe diseases such as cancer, lung diseases, and heart diseases of leather wor... |
39816728 | Unlocking Biochar's Potential: Innovative Strategies for Sustainable Remediation of Heavy Metal Stress in Tobacco Plants. | Tobacco, being a globally cultivated crop, holds significant social and economic importance. Tobacco plants are susceptible to the adverse effects of heavy metals (HMs), particularly cadmium (Cd), which hinders root development, disrupts water balance, and impedes nutrient absorption. Higher concentrations of HMs, espe... |
39811007 | Copper catalyzed selective methane oxidation to acetic acid using O<sub>2</sub>. | The direct transformation of methane into C<sub>2</sub> oxygenates such as acetic acid selectively using molecular oxygen (O<sub>2</sub>) is a significant challenge due to the chemical inertness of methane, the difficulty of methane C-H bond activation/C-C bond coupling and the thermodynamically favored over-oxidation.... |
39810997 | Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition. | Alzheimer's disease (AD) is the most prevalent neurodegenerative dementia, marked by progressive cognitive decline and memory impairment. Despite advances in therapeutic research, single-target-directed treatments often fall short in addressing the complex, multifactorial nature of AD. This arises from various patholog... |
39764852 | DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs. | Glucose binding can alter protein oligomerization to enable differentiation. Here, we demonstrate that glucose binding is a general capacity of DExD/H-box RNA helicases, including DDX50, which was found to be essential for the differentiation of diverse cell types. Glucose binding to conserved DDX50 ATP binding sequenc... |
39763276 | Pnictogen Bond-Mediated Coassemblies for Noncovalent Molecular Glass. | Pnictogen bond (PnB) occurring on the group-15 elements is recognized as σ- or π-hole-based interaction that has garnered attention in the fields of anion recognition and organocatalysis. Due to the polyvalent feature of pnictogens and high directionality, PnB possesses potential in the design of convergent coassembled... |
39763191 | Expanding the Functions of KHSRP Protein: Insights into DNA G-Quadruplex Binding. | KHSRP (KH-type splicing regulatory protein) is a multifunctional nucleic acid-binding protein that regulates various cellular processes, with critical roles in controlling gene expression. G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in essential cellular activities, including gene expression,... |
39763137 | Rapid Amplification and Detection of Single-Stranded Nucleic Acids for Point-of-Care Diagnosis. | Nucleic acid detection plays a crucial role in various applications, including disease diagnostics, research development, food safety, and environmental health monitoring. A rapid, point-of-care (POC) nucleic acid test can greatly benefit healthcare system by providing timely diagnosis for effective treatment and patie... |
39763134 | Unlocking Low-Temperature Ammonia Decomposition via an Iron Metal-Organic Framework-Derived Catalyst Under Photo-Thermal Conditions. | Photo-thermal catalysis, leveraging both thermal and non-thermal solar contributions, emerges as a sustainable approach for fuel and chemical synthesis. In this study, an Fe-based catalyst derived from a metal-organic framework is presented for efficient photo-thermal ammonia (NH<sub>3</sub>) decomposition. Optimal con... |
39763125 | Lab-on-the-Needles: A Microneedle Patch-Based Mobile Unit for Highly Sensitive <i>Ex Vivo</i> and <i>In Vivo</i> Detection of Protein Biomarkers. | Detection of biomarkers associated with physiological conditions provides critical insights into healthcare and disease management. However, challenges in sampling and analysis complicate the detection and quantification of protein biomarkers within the epidermal layer of the skin and in viscous liquid biopsy samples. ... |
39763116 | Photoexcited Electro-Driven Reactive Oxygen Species Channeling for Precise Extraction of Biomarker Information from Tumor Interstitial Fluid. | Direct electrochemical detection of miRNA biomarkers in tumor tissue interstitial fluid (TIF) holds great promise for adjuvant therapy for tumors in the perioperative period, yet is limited by background interference and weak signal. Herein, a wash-free and separation-free miRNA biosensor based on photoexcited electro-... |
39763104 | A Wireless Health Monitoring System Accomplishing Bimodal Decoupling Based on an "IS"-Shaped Multifunctional Conductive Hydrogel. | Flexible wearable sensors with bimodal functionality offer substantial value for human health monitoring, as relying on a single indicator is insufficient for capturing comprehensive physiological information. However, bimodal sensors face multiple challenges in practical applications, including mutual interference bet... |
39763100 | Colloid-Forming Prodrug-Hydrogel Composite Prolongs Lower Intraocular Pressure in Rodent Eyes after Subconjunctival Injection. | Colloidal drug aggregates (CDAs) are challenging in drug discovery due to their unpredictable formation and interference with screening assays. These limitations are turned into a strategic advantage by leveraging CDAs as a drug delivery platform. This study explores the deliberate formation and stabilization of CDAs f... |
39763089 | Supramolecular Coassembly Activated Dual-Excitation Fluorescent Sensing Platform for Precise Detection of Aflatoxin B<sub>1</sub>. | The development of a sensory signal amplification approach is very crucial for rapid and precise detection of aflatoxin B<sub>1</sub> (AFB<sub>1</sub>). However, such approaches remain scarce due to the weak interactions between AFB<sub>1</sub> and the sensing probes. Herein, the first example of a dual-excitation fluo... |
39763065 | Effect of Hyaluronan Molecular Weight on the Stability and Biofunctionality of Microfibers Assembled by Interfacial Polyelectrolyte Complexation. | Nervous system disorders are characterized by a progressive loss of function and structure of neurons that ultimately leads to a decline in cognitive and motor functions. In this study, we used interfacial polyelectrolyte complexation (IPC) to produce fibers for neural tissue regeneration. IPC is a processing method th... |
39763056 | The Effect of Accessibility of Insoluble Substrate on the Overall Kinetics of Enzymatic Degradation. | The enzymatic reaction kinetics on cellulose and other solid substrates is limited by the access of the enzyme to the reactive substrate sites. We introduce a general model in which the reaction rate is determined by the active surface area, and the resulting kinetics consequently reflects the evolving relationship bet... |
39762625 | Uniform single-crystal mesoporous metal-organic frameworks. | The synthesis of mesoporous metal-organic frameworks (meso-MOFs) is desirable as these materials can be used in various applications. However, owing to the imbalance in structural tension at the micro-scale (MOF crystallization) and the meso-scales (assembly of micelles with MOF subunits), the formation of single-cryst... |
39762199 | Integration of Immune Responses and Transcriptomic Signatures Reveals the Efficacy of Maternal Genetic Vaccination in a Pregnant Model and Its Neonates. | Maternal vaccination is essential for safeguarding both mother and foetus from infectious diseases. This study investigated the immunogenicity and efficacy of a maternal ORF-B2L genetic vaccine in a pregnant rat model, focusing on maternal-neonatal immune modulation, placental and neonatal spleen transcriptomics and th... |
39762158 | Boosting the Actuation Performance of a Dynamic Supramolecular Polyurethane-Urea Elastomer via Kinetic Control. | The ongoing soft actuation has accentuated the demand for dielectric elastomers (DEs) capable of large deformation to replace the traditional rigid mechanical apparatus. However, the low actuation strain of DEs considerably limits their practical applications. This work developed high-performance polyurethane-urea (PUU... |
39762157 | Self-Healing Flexible Fiber Optic Sensors for Safe Underwater Monitoring. | The advancement of underwater monitoring technologies has been significantly hampered by the limitations of traditional electrical sensors, particularly in the presence of electromagnetic interference and safety concerns in aquatic environments. Fiber optic sensors are therefore nowadays widely applied to underwater mo... |
39762152 | Reduced Uptake of Oxidized Low-Density Lipoprotein by Macrophages Using Multiple Aptamer Combinations. | The accumulation of oxidized low-density lipoprotein (oxLDL) in macrophages leads to the formation of foam cells and atherosclerosis development. Reducing the uptake of oxLDL in macrophages decreases the incidence and progression of atherosclerosis. Four distinct single-strand DNA sequences, namely, AP07, AP11, AP25, a... |
39762089 | Laser-Induced Metal-Organic Framework-Derived Flexible Electrodes for Electrochemical Sensing. | The successful development of a metal-organic framework (MOF)-derived Co/Co<sub>3</sub>O<sub>4</sub>/C core-shell composite integrated into laser-induced graphitic (LIG) carbon electrodes for electrochemical sensing is reported. The sensors are fabricated via a direct laser scribing technique using a UV laser (355 nm w... |
39762079 | CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment. | <h4>Background</h4>To date, a growing body of evidence suggests that unfolded protein response (UPR) sensors play a vital role in carcinogenesis. However, it remains unclear whether they are involved in pancreatic ductal adenocarcinoma (PDAC) and how they relate to clinical outcomes. This study aims to investigate the ... |
39761295 | NMR spectroscopy derived plasma biomarkers of inflammation in human populations: Influences of age, sex and adiposity. | Understanding the distribution and variation in inflammatory markers is crucial for advancing our knowledge of inflammatory processes and evaluating their clinical utility in diagnosing and monitoring acute and chronic disease. 1H NMR spectroscopy of blood plasma and serum was applied to measure a composite panel of in... |
39761280 | Genetic variation of hemolysin co-regulated protein 1 affects the immunogenicity and pathogenicity of Burkholderia pseudomallei. | Hemolysin co-regulated protein 1 (Hcp1) is a component of the cluster 1 Type VI secretion system (T6SS1) that plays a key role during the intracellular lifecycle of Burkholderia pseudomallei. Hcp1 is recognized as a promising target antigen for developing melioidosis diagnostics and vaccines. While the gene encoding Hc... |
39761200 | Precise Control of Efficient Phosphorescence in Host-Guest Doping Systems via Dynamic Metal-Ligand Coordination. | Organic room-temperature phosphorescent (RTP) materials have wide-ranging applications in anticounterfeiting, biodiagnostics, and optoelectronic devices due to their unique properties. However, it remains a challenge to give organic RTP materials dynamic tunability to satisfy the demands of various advanced application... |
39802388 | Cellulose Based Nano-Scaffolds for Targeted Cancer Therapies: Current Status and Future Perspective. | In the last few years, cellulose has garnered much interest for its application in drug delivery, especially in cancer therapy. It has special properties like biocompatibility, biodegradability, high porosity, and water permeability render it a good candidate for developing efficient carriers for anticancer agents. Cel... |
39802379 | <sub>h</sub>CeO<sub>2</sub>@CA-074Me Nanoparticles Alleviate Inflammation and Improve Osteogenic Microenvironment by Regulating the CTSB-NLRP3 Signaling Pathway. | <h4>Background</h4>It is well established that the interaction between osteogenesis and inflammation can impact bone tissue regeneration. The use of nanoparticles to treat and alleviate inflammation at the molecular level has the potential to improve the osteogenic microenvironment and serve as a therapeutic approach.<... |
39802380 | Novel Modifications and Delivery Modes of Cyclic Dinucleotides for STING Activation in Cancer Treatment. | The microenvironment tends to be immunosuppressive during tumor growth and proliferation. Immunotherapy has attracted much attention because of its ability to activate tumor-specific immune responses for tumor killing. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is an innate immune p... |
39799807 | Water-mediated cytosine self-assembly in infrared perspective. | Self-assembly plays a crucial role in the formation and allosteric processes of many biomolecules, water molecules can affect these processes. Cytosine (Cyt) has excellent self-assembly ability, forming a flat and ordered structure through hydrogen bonds (HBs) in the presence of water molecules. However, the vibration ... |
39799697 | Albumin-seeking NIR dyes for high-sensitive imaging of glomerular filtration barrier breakdown. | The kidney, vital for metabolic balance, faces risks of severe diseases if dysfunctional. The glomerular filtration barrier (GFB), crucial for blood filtration, disrupts in conditions like diabetic nephropathy or nephritides, resulting in proteinuria or even renal failure. Monitoring GFB integrity is essential for earl... |
39799624 | Synthesis of Mn-doped hollow octahedron ZnIn<sub>2</sub>S<sub>4</sub> to enhance photocatalytic hydrogen production performance utilizing metal-organic framework as template. | Designing semiconductor photocatalysts with unique structures can improve the transfer efficiency of solar energy to hydrogen (H<sub>2</sub>). In this study, a dual modification method of element doping and morphological control was used. The Mn-doped hollow octahedron ZnIn<sub>2</sub>S<sub>4</sub> (ZHO-Mn) was synthes... |
39799622 | Phosphate-adsorbed metal organic framework as a recycled material for catalytic degradation of ceftriaxone sodium via peroxymonosulfate activation. | In this study, the zirconium-based metal organic framework (Zr-MOF) was applied as the adsorbent for phosphorus (P) pollution in water. Then the phosphate-adsorbed metal organic frameworks (MOFs) were used as a recycled raw material and calcined to obtain P-doped MOFs-derived carbon material (ZrP@Zr-BTC). Next, the ZrP... |
39798424 | CO driven tunable syngas synthesis via CO<sub>2</sub> photoreduction using a novel NiCo bimetallic metal-organic frameworks. | Syngas has important industrial applications, and converting CO<sub>2</sub> to CO is critical for syngas production. Metal-organic frameworks (MOFs) have demonstrated significant potential in photocatalytic syngas conversion, although the impact of catalytic reactions on tunable H<sub>2</sub>/CO ratios remains unclear.... |
39798379 | A novel electrochemiluminescence sensor based on NiCo NCs@C<sub>3</sub>N QDs nanocomposites with poly-L-cysteine as co-reaction accelerator for ultrasensitive detection of vitamin K<sub>1</sub>. | A novel electrochemiluminescence (ECL) sensor based on eco-friendly C<sub>3</sub>N QDs was constructed for the ultrasensitive detection of VK<sub>1</sub>. The synthesized NiCo nanocages (NiCo NCs) with large specific surface area and high catalytic activity were used to effectively load C<sub>3</sub>N QDs, forming the ... |
39797372 | Macular Pigment Changes and Visual Recovery Following Successful Full-Thickness Macular Hole Closure Using the Inverted Flap Technique. | <b>Objectives</b>: This study aimed to assess the role of macular pigment optical density (MPOD) in patients with a full-thickness macular hole (FTMH) compared to healthy controls, evaluating postoperative changes in MPOD and exploring potential correlations with visual outcomes. <b>Methods</b>: This prospective, cross... |
39796426 | Development and Assessment of a Color-Variable Chlorine Dioxide Slow-Releasing Card for Litchi Preservation. | Chlorine dioxide (ClO<sub>2</sub>) gas has attracted considerable attention due to its safety and efficiency. In this study, we successfully developed a color-variable ClO<sub>2</sub> slow-releasing card for postharvest litchi. The optimal ClO<sub>2</sub> slow-releasing card was prepared as follows: Card A was soaked i... |
39795522 | Carbon Nanotube/Polymer Composites for Functional Applications. | Carbon nanotubes (CNTs) have garnered significant interest in the field of nanotechnology owing to their unique structure and exceptional properties. These materials find applications across a diverse array of fields, including electronics, environmental science, energy, and biotechnology. CNTs serve as potent reinforc... |
39795247 | Scaling Behavior of Ionic Conductance Dependent on Surface Charge Inside a Single-Digit Nanopore. | The ionic conductance in a charged nanopore exhibits a power-law behavior in low salinity-as has been verified in many experiments (G0∝c0α)-which is governed by surface charges. The surface charge inside a nanopore determines the zeta potential and ion distributions, which have a significant impact on ion transport, es... |
39795249 | Luminescent Iridium-Terpyridine Complexes with Various Bis-Cyclometalated Ligands. | A series of luminescent bis-cyclometalated iridium complexes with 2,2':6',2″-terpyridine (tpy), [Ir(<i>C^N</i>)<sub>2</sub>(tpy)]PF<sub>6</sub> (<i>C^N</i> = 2-phenylpyridinate (ppy) for <b>1</b>; benzo[h]quinolinate (bzq) for <b>2</b>; 1-phenylisoquinolinate (piq) for <b>3</b>; and 2-phenylbenzothiazolate (pbt) for <b... |
39793362 | Insights into the differences of caspase and apoptosis levels in pork longissimus thoracis muscles with different tenderness: A perspective on S-nitrosylation modification. | This study investigated the differences of caspase and apoptosis levels in pork with different tenderness from the perspective of S-nitrosylation and further explored their role during pork tenderization. Ten longissimus thoracis muscles selected from 36 individual carcasses based on shear force were divided into high ... |
39791836 | Laser Synthesis of Platinum Single-Atom Catalysts for Hydrogen Evolution Reaction. | Platinum (Pt)-based heterogeneous catalysts show excellent performance for the electrocatalytic hydrogen evolution reaction (HER); however, the high cost and earth paucity of Pt means that efforts are being directed to reducing Pt usage, whilst maximizing catalytic efficiency. In this work, a two-step laser annealing p... |
39778836 | Preparation of dual supramolecular EGCG-carboxymethyl chitosan: Structure, antioxidant and anti-inflammatory properties. | In the field of cosmetics, epigallocatechin gallate (EGCG) is highly valued for its multiple effects such as delaying photoaging, whitening, anti-allergy, acne removal, astringency, and moisturizing. However, due to the active chemical properties of EGCG, there are challenges in terms of stability and transdermal absor... |
39778828 | Understanding the role of Radix Paeoniae Alba polysaccharide for corn starch gel amelioration: Physicochemical, structural, and digestive properties. | To ameliorate the limitations of corn starch (CS) processing, Radix Paeoniae Alba polysaccharide (RPAP) was used to modulate the physicochemical and digestive properties of CS. The main purpose of this paper is to investigate the effects of RPAP on the pasting, rheological, thermal, structural, and digestive properties... |
39778617 | A novel MOF-on-MOF-derived carbon-encapsulated CeO<sub>2</sub>/Co/Co<sub>3</sub>O<sub>4</sub> humidity-resistant heterojunction with abundant oxygen vacancies for efficient ozone removal. | Ground-level ozone (O<sub>3</sub>) can infiltrate indoor environments, severely impacting the environment and human health. Moisture-induced catalyst deactivation is a major challenge in catalytic ozone removal. MOF-template-derived heterojunctions supported by carbon materials can prevent chemisorption of water vapor ... |
39762996 | Fabrication of promising competitive graphene nanocomposite transducer to determine Prucalopride succinate in pharmaceutical formulation and in spiked human biological fluids. | The development of a newly fabricated ion-selective electrode (ISE) solid-contacted type for the determination of prucalopride succinate represents a significant advancement in analytical chemistry, particularly in the context of green chemistry principles. The optimization process involved numerous trials to ensure th... |
39762875 | mRNA vaccines in the context of cancer treatment: from concept to application. | Immuno-oncology has witnessed remarkable advancements in the past decade, revolutionizing the landscape of cancer therapeutics in an encouraging manner. Among the diverse immunotherapy strategies, mRNA vaccines have ushered in a new era for the therapeutic management of malignant diseases, primarily due to their impres... |
39762869 | Chitosan nano-formulation enhances stability and bactericidal activity of the lytic phage HK6. | <h4>Background</h4>Successful treatment of pathogenic bacteria like Enterobacter Cloacae with bacteriophage (phage) counteract some hindrance such as phage stability and immunological clearance. Our research is focused on the encapsulation of phage HK6 within chitosan nanoparticles.<h4>Result</h4>Encapsulation signific... |
39762846 | Promising new drugs and therapeutic approaches for treatment of ovarian cancer-targeting the hallmarks of cancer. | Ovarian cancer remains the most lethal gynecological malignancy. Despite the approval of promising targeted therapy such as bevacizumab and PARP inhibitors, 5-year survival has not improved significantly. Thus, there is an urgent need for new therapeutics. New advancements in therapeutic strategies target the pivotal h... |
39762758 | Virtual screening assisted identification of a phytocompound as potent inhibitor against Candida lusitaniae; an in-silico study. | Candida lusitaniae is one of the fungal species which causes serious health illnesses including peritonitis, vaginitis and fungemia, among others. Several antifungal drugs have been designed to tackle its infections but their efficacy is still questionable due to their associated side effects. Hence, there is a need to... |
39762455 | Assessment of the potential and application of Be<sub>12</sub>O<sub>12</sub> nanocage for removal of ciprofloxacin from water employing density functional theory. | The modern world is facing the issue of emerging pollutants for its sustainable development. We report a detailed study on the abatement of ciprofloxacin (CIP) by Be<sub>12</sub>O<sub>12</sub> nanocage. Five different geometries of Be<sub>12</sub>O<sub>12</sub> nanocage with CIP i.e., Com-A, Com-B, Com-C, Com-D and Com... |
39762450 | Mucosal-adapted bacteriophages as a preventive strategy for a lethal Pseudomonas aeruginosa challenge in mice. | Pseudomonas aeruginosa is an emergent threat due to the antimicrobial resistance crisis. Bacteriophages (phages) are promising agents for phage therapy approaches against P. aeruginosa. It has been proposed that metazoans harbor phages on their mucosal surfaces, and this could be exploited for the rational design of pr... |
39762350 | Thio-modified trianglimines, a novel group of chiral macrocyclic compounds of high structural dynamics. | The embellishing of the macrocycle core with sulfur substituents of varied sterical requirements changes the structural dynamics of chiral, triangular polyimines. Despite their formal high symmetry, these compounds adopt diverse conformations, in which the macrocycle core represents a non-changeable unit. DFT calculati... |
39762357 | Optimisation of the crystallisation process through staggered cooling in a nonvibrating granular system. | We study experimentally the optimisation of the crystallisation process through a 2D-dimensional system of magnetic particles under an oscillating magnetic field. The time-dependent magnetic field fluidises the system, and by varying its magnitude, the effective temperature of the system is controlled. The system exhib... |
39762342 | Core-genome guided novel therapeutic targets identification and chimeric vaccine designing against Rickettsia rickettsii. | Rocky Mountain Spotted Fever, caused by the gram-negative intracellular bacteria Rickettsia rickettsii, is a serious tick-borne infection with a fatality rate of 20-30%, if not treated. Since it is the most serious rickettsial disease in North America, modified prevention and treatment strategies are of critical import... |
39762329 | Termination-acidity tailoring of molybdenum carbides for alkaline hydrogen evolution reaction. | Transition-metal carbides have been advocated as the promising alternatives to noble-metal platinum-based catalysts in electrocatalytic hydrogen evolution reaction over half a century. However, the effectiveness of transition-metal carbides catalyzing hydrogen evolution in high-pH electrolyte is severely compromised du... |
39762246 | Elastic, strong and tough ionically conductive elastomers. | Stretchable elastic materials with high strength, toughness, and good ionic conductivity are highly desirable for wearable devices and stretchable batteries. Unfortunately, limited success has been reported to attain all of these properties simultaneously. Here, we report a family of ionically conductive elastomers (IC... |
39762241 | Optomechanical micro-rheology of complex fluids at ultra-high frequency. | We present an optomechanical method for locally measuring the rheological properties of complex fluids in the ultra-high frequency range (UHF). A mechanical disk of microscale volume is used as an oscillating probe that monitors a liquid at rest, while the oscillation is optomechanically transduced. An analytical model... |
39762236 | Aurophilic interaction-based aggregation of gem-digold(I) aryls towards high spin-orbit coupling and strong phosphorescence. | Luminescent gold(I) compounds have attracted intensive attention due to anticipated strong spin-orbit coupling (SOC) resulting from heavy atom effect of gold atoms. However, some mononuclear gold(I) compounds are barely satisfactory. Here, we unveil that low participation of gold in transition-related orbitals, caused ... |
39761101 | Phase Characterization and Bioactivity Evaluation of Nucleic Acid-Encapsulated Biomimetically Mineralized ZIF-8. | Metal-organic frameworks (MOFs) provide diverse applications across a wide range of scientific disciplines, including drug/nucleic acid (NA) delivery. In the subclass of MOFs, zeolitic imidazolate framework-8 (ZIF-8) is well regarded due to its exceptional physicochemical properties. Biomolecules can be encapsulated an... |
39761079 | Molecular Simulation Study of All-Silica Zeolites for the Adsorptive Removal of Airborne Chloroethenes. | Chloroethenes (C<sub>2</sub>H<sub>4-<i>x</i></sub>Cl<sub><i>x</i></sub> with <i>x</i> = 1, 2, 3, 4) are produced and consumed in various industrial processes. As the release of these compounds into air, water, and soils can pose significant risks to human health and the environment, different techniques have been explo... |
39761059 | Thermal Actuators Relying on Elastomer-Dispersed Liquid Crystals: From Imines with Supramolecular Chirality and Ferroelectricity to Soft Robots. | The locomotion of various organisms relies on the alternated elongation-contraction of their muscles or bodies. Such biomimicry can offer a promising approach to developing soft robotic devices with improved mobility and efficiency. Most strategies to mimic such motions rely on reversible size modifications of some mat... |
39761029 | Fluorous-Phase- and Chiral-Axis-Enhanced Fluorescent Sensitivity and Chemoselectivity for Cysteine Recognition. | Highly fluorinated naphthyl aldehyde <b>1</b> and binaphthyl aldehyde (<i>R</i>)-<b>2</b> were designed and synthesized for fluorous-phase-based sensing. Greatly enhanced sensitivity and chemoselectivity in going from <b>1</b> to (<i>R</i>)-<b>2</b> in the fluorescent detection of cysteine has been discovered. This is ... |
39760789 | Targeted Covalent Nanodrugs Reinvigorate Antitumor Immunity and Kill Tumors via Improving Intratumoral Accumulation and Retention of Doxorubicin. | Specifically improving the intratumoral accumulation and retention and achieving the maximum therapeutic efficacy of small-molecule chemotherapeutics remains a considerable challenge. To address the issue, we here reported near-infrared (NIR) irradiation-activatable targeted covalent nanodrugs by installing diazirine-l... |
39760709 | Sub-5 Ångstrom Porosity Tuning in Calixarene-Derived Porous Liquids via Supramolecular Complexation Construction. | Sub-Ångstrom-level porosity engineering, which is appealing in gas separations, has been demonstrated in solid carbon, polymer, and framework materials but rarely achieved in the liquid phase. In this work, a gas molecular sieving effect in the liquid phase at sub-5 Ångstrom scale is created via sophisticated porosity ... |
39760663 | Conductive MOF-Derived Coating for Suppressing the Mn Dissolution in LiMn<sub>2</sub>O<sub>4</sub> toward Long-Life Lithium-Ion Batteries. | Spinel lithium manganese oxide (LiMn<sub>2</sub>O<sub>4</sub>, LMO) is a promising cathode material with nontoxicity, high operating voltage, and low cost. However, structural collapse during battery cycling ─ caused by Mn dissolution and the Jahn-Teller effect ─ is a critical disadvantage, reducing cycle retention, pa... |
39760492 | Betacoronavirus internal protein: role in immune evasion and viral pathogenesis. | Betacoronaviruses express a small internal (I) protein that is encoded by the same subgenomic RNA (sgRNA) as the nucleocapsid (N) protein. Translation of the +1 reading frame of the N sgRNA through leaky ribosomal scanning leads to expression of the I protein. The I protein is an accessory protein reported to evade hos... |
39760461 | Autonomous Nucleic Acid and Protein Nanocomputing Agents Engineered to Operate in Living Cells. | In recent years, the rapid development and employment of autonomous technology have been observed in many areas of human activity. Autonomous technology can readily adjust its function to environmental conditions and enable an efficient operation without human control. While applying the same concept to designing advan... |
39760372 | Influence of Tacticity on the Self-Assembly of Poly(ethylene glycol)-<i>b</i>-poly(lactic acid) Block Copolymers. | Lactide, possessing two stereocenters and thus three distinct configurations (DD, DL, and LL), serves as a captivating building block for polymers and self-assembly. Notably, polylactide (PLA) exhibits stereocomplexation, displaying heightened interactions between different configurations compared with interactions wit... |
39760286 | Mesoscopic Morphologies in Frustrated ABC Bottlebrush Block Terpolymers. | Bottlebrush block polymers, characterized by densely grafted side chains extending from a backbone, have recently garnered significant attention. A particularly attractive feature is the accessibility of ordered morphologies with domain spacings exceeding several hundred nanometers, a capability that is challenging to ... |
39758030 | The highly pathogenic strain of porcine deltacoronavirus disrupts the intestinal barrier and causes diarrhea in newborn piglets. | Porcine deltacoronavirus (PDCoV) is increasingly prevalent in newborn piglets with diarrhea. With the development of research on the virus and the feasibility of PDCoV cross-species transmission, the biosafety and the development of pig industry have been greatly affected. In this study, a PDCoV strain CH/LNFX/2022 was... |
39757858 | SARS-COV-2 Pre-Exposure Prophylaxis With Tixagevimab-Cilgavimab in Haematological, Immunocompromised Patients in the Omicron Era. | <h4>Background</h4>Pre-exposure prophylaxis with tixagevimab-cilgavimab significantly reduced severe COVID-19 outcomes in high-risk individuals during the pre-Omicron era (PROVENT trial). However, efficacy in patients with haematological malignancies (HM) was underreported. The rapid emergence of Omicron strains in 202... |
39757838 | Infection Diagnostics Enabled by Selective Adsorption of Breath-Based Biomarkers in Zr-Based Metal-Organic Frameworks. | Exhaled breath contains trace levels of volatile organic compounds (VOCs) that can reveal information about metabolic processes or pathogens in the body. These molecules can be used for medical diagnosis, but capturing and accurately measuring them is a significant challenge in chemical separations. A highly selective ... |
39757835 | Spin Glass Transition of Magnetic Ionic Liquids Induced by Self-Assembly. | Spin glass (SG), in which the spins are glassy, has attracted broad attention for theoretical study and prospective application. SG states are generally related to disordered or frustrated spin systems, which are usually observed in inorganic magnets. Herein, supramolecular magnetic ionic liquid (TMTBDI[FeCl<sub>4</sub... |
39757799 | Differential Diagnosis of Urinary Cancers by Surface-Enhanced Raman Spectroscopy and Machine Learning. | Bladder, kidney, and prostate cancers are prevalent urinary cancers, and developing efficient detection methods is of significance for the early diagnosis of them. However, noninvasive and sensitive detection of urinary cancers still challenges traditional techniques. In this study, we developed a SERS-based method to ... |
39757305 | LncRNA MIR210HG promotes the proliferation of colon cancer cells by inhibiting ferroptosis through binding to PCBP1. | This study aimed to investigate the role of the MIR210 host gene (MIR210HG), a long noncoding RNA (lncRNA), in the proliferation of colon cancer cells and its potential mechanism involving the ferroptosis pathway. We assessed MIR210HG expression in colon cancer cell lines and tissues, and examined the effects of its ov... |
39757214 | Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets. | Cells orchestrate their processes through complex interactions, precisely organizing biomolecules in space and time. Recent discoveries have highlighted the crucial role of biomolecular condensates-membrane-less assemblies formed through the condensation of proteins, nucleic acids, and other molecules-in driving effici... |
39629897 | Novel Class of Ambipolar Columnar Liquid Crystals Based on Cyclic Dipeptide and Isatin Hybrids. | A new class of cyclic dipeptide-isatin hybrids was synthesized using 2,5-diketopiperazine and various isatin derivatives bearing flexible chains and extended aromatic rings in a double Knoevenagel condensation process. These new series demonstrate high solubility and good thermal stability with decomposition temperatur... |
40636302 | Purification of Monoclonal Antibodies Using Chromatographic Methods: Increasing Purity and Recovery. | Monoclonal antibodies (mAbs) have gained increasing significance in biopharmaceutical research and production because of their precise targeting and therapeutic potential. The purification of mAbs is a crucial stage in production, ensuring the elimination of impurities for a top-quality, safe, and efficient final produ... |
40625566 | Rational design of deep eutectic solvents with low viscosities and multiple active sites for efficient recognition and selective capture of NH<sub>3</sub>. | Efficient recognition and selective capture of NH<sub>3</sub> is not only beneficial for increasing the productivity of the synthetic NH<sub>3</sub> industry but also for reducing air pollution. For this purpose, a group of deep eutectic solvents (DESs) consisting of glycolic acid (GA) and phenol (PhOH) with low viscos... |
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