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39861710 | Hydrogels of Poly(2-hydroxyethyl methacrylate) and Poly(N,N-dimethylacrylamide) Interpenetrating Polymer Networks as Dermal Delivery Systems for Dexamethasone. | <b>Background/Objectives</b>: This study is an attempt to reveal the potential of two types of interpenetrating polymer network (IPN) hydrogels based on poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(N,N-dimethylacrylamide) (PDMAM). These IPNs were evaluated for their potential for dermal delivery of the hydrophobi... |
39861711 | Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid-A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends. | Self-emulsifying drug delivery systems (SEDDS) represent an innovative approach to improving the solubility and bioavailability of poorly water-soluble drugs, addressing significant challenges associated with oral drug delivery. This review highlights the advancements and applications of SEDDS, including their transiti... |
39861709 | Ashwagandha: Optimizing the Extraction and Electrospun Nanofiber Production. | <b>Background/Objectives:</b> This study explores the development of electrospun nanofibers incorporating bioactive compounds from <i>Withania somnifera</i> (Ashwagandha) root extract, focusing on optimizing extraction conditions and nanofiber composition to maximize biological activity and application potential. <b>Me... |
39852527 | Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023. | Angucyclines/angucyclinones, a class of polyketides with diverse chemical structures, display various bioactivities including antibacterial or antifungal, anticancer, anti-neuroinflammatory, and anti-α-glucosidase activities. Marine and terrestrial microorganisms have made significant contributions to the discovery of ... |
39795244 | Pt@ZnCo<sub>2</sub>O<sub>4</sub> Microspheres as Peroxidase Mimics: Enhanced Catalytic Activity and Application for L-Cysteine Detection. | Compared to natural enzymes, the development of efficient artificial simulated enzymes, such as those based on bimetallic materials with high catalytic activity and good stability, is an important way until now. Herein, we employed ZnCo<sub>2</sub>O<sub>4</sub> microspheres as carriers to synthesize Pt-doped composites... |
39764565 | Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions. | Sarcopenia is defined as a muscle-wasting syndrome that occurs with accelerated aging, while cachexia is a severe wasting syndrome associated with conditions such as cancer and immunodeficiency disorders, which cannot be fully addressed through conventional nutritional supplementation. Sarcopenia can be considered a co... |
39795843 | The Effects of Chain Conformation and Nanostructure on the Dielectric Properties of Polymers. | The dielectric properties of polymers play a pivotal role in the development of advanced materials for energy storage, electronics, and insulation. This review comprehensively explores the critical relationship between polymer chain conformation, nanostructure, and dielectric properties, focusing on parameters such as ... |
39795844 | Shape-Persistent Tetraphenylethylene Macrocycle: Highly Efficient Synthesis and Circularly Polarized Luminescence. | Circularly polarized luminescence (CPL) is an emerging field with significant applications in molecular electronics, optical materials, and chiroptical sensing. Achieving efficient CPL emission in organic systems remains a major challenge, particularly in the development of materials with high fluorescence quantum yiel... |
39795236 | Electrochemical Sensor Based on Co-MOF for the Detection of Dihydromyricetin in <i>Ampelopsis grossedentata</i>. | Dihydromyricetin (DMY), as the main active ingredient in <i>Ampelopsis grossedentata</i>, is a naturally occurring flavonoid that has attracted extensive attention for its multiple biological activities. For the quick and accurate measurement of DMY, a novel electrochemical sensor based on a glassy carbon electrode (GC... |
39795048 | Dietary Tryptophan Requirement of Juvenile Hybrid Grouper (<i>Epinephelus fuscoguttatus</i>♀ <i>× E. lanceolatus</i>♂). | A 10-week feeding study was conducted to examine the effects of dietary tryptophan (Trp) levels on the growth performance and protein metabolism of hybrid grouper (<i>Epinephelus fuscoguttatus</i>♀ × <i>E. lanceolatus</i>♂) with the aim of determining the optimal Trp requirement. Six isonitrogenous and isolipidic exper... |
39787838 | Lithium complexing strategy based on host-guest recognition for efficient Mg<sup>2+</sup>/Li<sup>+</sup> separation. | Ion selective membranes with precise Mg<sup>2+</sup>/Li<sup>+</sup> separation have attracted extensive interest in lithium extraction to circumvent the lithium supply shortage. However, realizing this target remains a significant challenge mainly due to a high concentration ratio of Mg<sup>2+</sup>/Li<sup>+</sup> as w... |
39787779 | Organophosphate esters inhibit enzymatic proteolysis through non-covalent interactions. | Enzymatic proteolysis is the key process to produce bioavailable nitrogen in natural terrestrial and aquatic ecosystems for microorganisms and plants. However, little is known on how protein degradation is influenced by organic contaminants. As we known, the overuse of organophosphate esters (OPEs) has caused serious p... |
39778221 | Computational exploration of the self-aggregation mechanisms of phenol-soluble modulins β1 and β2 in Staphylococcus aureus biofilms. | The formation of functional bacterial amyloids by phenol-soluble modulins (PSMs) in Staphylococcus aureus is a critical component of biofilm-associated infections, providing robust protective barriers against antimicrobial agents and immune defenses. Clarifying the molecular mechanisms of PSM self-assembly within the b... |
39765294 | A "cyclodextrin-salicylic acid-chitosan" bifunctional monomer magnetic hydrophilic imprinted sandwich gel for targeted adsorption and slow release of ginkgolic acid. | This study aims to address the challenge of detoxifying ginkgolic acid and transform it from waste into a valuable resource. By using pseudo-template molecular imprinting technology to chemically modify polysaccharide materials, we developed a polysaccharide-based molecular imprinted material (MMCC-CD/CS-MIP) for the t... |
39757753 | Polycationic γ-Cyclodextrin with Amino Side Chains for a Highly Efficient Anti-Heparin Coagulant. | Multicharged cyclodextrins have attracted significant attention because of their applications in biology and pharmaceuticals. This study reports an aminoethoxy-phenyl-pyridinium-modified γ-cyclodextrin (PyA-γ-CD) as a highly efficient coagulant for heparin through multivalent interactions. The UV titration experiment i... |
39757721 | Cargo hitchhiking autophagy - a hybrid autophagy pathway utilized in yeast. | Macroautophagy is a catabolic process that maintains cellular homeostasis by recycling intracellular material through the use of double-membrane vesicles called autophagosomes. In turn, autophagosomes fuse with vacuoles (in yeast and plants) or lysosomes (in metazoans), where resident hydrolases degrade the cargo. Give... |
39757712 | A Bioinspired Antifouling Coating Based on "Host-Guest Interaction" Strategy: Durable Slipperiness and Tunable Transparency. | Lubricant-mediated surfaces limit their practical application in transparent antifouling due to the inherent drawbacks of lubricant loss and poor transparency. Liquid-Like Surfaces(LLSs)are expected to solve these problems. Herein, inspired by the skin structure of globefish, some slippery LLSs are prepared with the cy... |
39757706 | A Modular Self-Assembling and Self-Adjuvanting Multiepitope Peptide Nanoparticle Vaccine Platform to Improve the Efficacy and Immunogenicity of BCG. | After more than a century since its initial development, Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB). Subunit boosters are considered a viable strategy to enhance BCG efficacy, which often wanes in adolescence. While many studies on booster subunit vaccines have concentrate... |
39757546 | Ordered Photoexfoliation for Polypseudorotaxane Nanosheets. | Two-dimensional layered structural materials exhibit a wide range of properties due to their ultrahigh specific surface area. However, achieving ordered exfoliation to obtain uniform two-dimensional structures remains challenging. In this study, we developed a supramolecular system by covalently bonding hexathiobenzene... |
39757545 | Probing Magnetism in Self-Assembled Organometallic Complexes Using Kondo Spectroscopy. | Control of individual spins at the atomic level holds great promise for miniaturized spintronics, quantum sensing, and quantum information processing. Both single atomic and molecular spin centers are prime candidates for these applications and are often individually addressed and manipulated using scanning tunneling m... |
39757528 | A Bio-Inspired Perspective on Materials Sustainability. | The article explores materials sustainability through a bio-inspired lens and discusses paradigms that can reshape the understanding of material synthesis, processing, and usage. It addresses various technological fields, from structural engineering to healthcare, and emphasizes natural material cycles as a blueprint f... |
39757519 | Porphyrin-Based Metal-Organic Framework Photocatalysts: Structure, Mechanism and Applications. | In recent years, porphyrins have been frequently reported as photocatalysts due to their fascinating photochemical properties. However, porphyrins have the same shortcomings as other homogeneous photocatalysts, such as poor stability and difficulty in recovering. To solve this problem, it is a good strategy to form a p... |
39757512 | MOF-Derived Hierarchically Porous Carbon with Orthogonal Channels for Advanced Na-Se Batteries. | Na-Se batteries with high theoretical capacity and rich natural abundance are regarded as desirable substitutes for lithium-ion batteries in the predicament of scarce lithium resources. However, the huge volume expansion of Se and the shuttling effect of polyselenides hinder the development of Na-Se batteries. Herein, ... |
39757511 | Fecal Metaproteomics as a Tool to Monitor Functional Modifications Induced in the Gut Microbiota by Ketogenic Diet: A Case Study. | Metaproteomics is a valuable approach to characterize the biological functions involved in the gut microbiota (GM) response to dietary interventions. Ketogenic diets (KDs) are very effective in controlling seizure severity and frequency in drug-resistant epilepsy (DRE) and in the weight loss management in obese/overwei... |
39757498 | Asymmetric Microgels with Tunable Morphologies by Assembly-Guided Polymerization of Liquid Crystalline Monomers. | Understanding and controlling the morphology of microgels is crucial for optimizing their properties and functions in diverse areas of application. The fabrication of microgels that exhibit both structural and chemical anisotropy using a template-free approach faces significant challenges. Existing approaches toward su... |
39757493 | Co<sub>3</sub>O<sub>4</sub> with the Enhancement of Peroxymonosulfate Adsorption Capacity by Rare Earth Europium-Doping for High-Efficiency Organic Dye Degradation. | Cobalt-based metal-organic framework (MOFs)-derived catalysts are acknowledged for their effectiveness in activating peroxymonosulfate (PMS) for the treatment of persistent pollutants. However, the limited adsorption of PMS on the catalyst surface markedly reduces its degradation efficiency. To overcome this limitation... |
39757489 | Enhanced Electrochemical Performance of Polyaniline-Boron Doped Diamond Electrode for Supercapacitor Applications. | Understanding how to tune the properties of electroactive materials is a key parameter for their applications in energy storage systems. This work presents a comprehensive study in tailoring polyaniline (PANI) suspensions by acid-assisted polymerization method and their subsequent deposition on boron-doped diamond (BDD... |
39757486 | Light-Controlled Intracellular Synthesis of Poly(luciferin) Polymers Induces Cell Paraptosis. | Accumulation of misfolded proteins challenges cellular proteostasis and is implicated in aging and chronic disorders. Cancer cells, moreover, face an elevated level of basal proteotoxic stress; hence, exacerbating endoplasmic reticulum (ER) stress has been shown to induce programmed cell death while enhancing anticance... |
39757485 | Multifunctional Carbon Dots In Situ Confined Hydrogel for Optical Communication, Drug Delivery, pH Sensing, Nanozymatic Activity, and UV Shielding Applications. | Inspired by the emerging potential of photoluminescent hydrogels, this work unlocks new avenues for advanced biosensing, bioimaging, and drug delivery applications. Carbon quantum dots (CDs) are deemed particularly promising among various optical dyes, for enhancing polymeric networks with superior physical and chemica... |
39757461 | A Slimming/Excavating Strategy for Enhanced Intratumoral Penetration of Acid-Disassemblable NO-Releasing Nanomedicines. | Poor tumor penetration is the major predicament of nanomedicines that limits their anticancer efficacy. The dense extracellular matrix (ECM) in the tumor is one of the major barriers against the deep penetration of nanomedicines. In this work, a slimming/excavating strategy is proposed for enhanced intratumoral penetra... |
39757459 | Regulating Supramolecular Assembly and Disassembly of Chitosan toward Efficiently Antibacterial Lubricous and Biodegradable Hydrogel Urinary Catheters. | Urinary catheters serve as critical medical devices in clinical practice. However, the currently used urinary catheters lack efficient antibacterial and lubricating properties, often leading to discomfort with patients and even severe urinary infections. Herein, a new strategy of supramolecular assembly and disassembly... |
39757431 | Nanostructured Surfaces with Plasmonic Activity and Superhydrophobicity: Review of Fabrication Strategies and Applications. | Plasmonics and superhydrophobicity have garnered broad interest from academics and industry alike, spanning fundamental scientific inquiry and practical technological applications. Plasmonic activity and superhydrophobicity rely heavily on nanostructured surfaces, providing opportunities for their mutually beneficial i... |
39757429 | Water Spillover to Expedite Two-Electron Oxygen Reduction. | Limited by the activity-selectivity trade-off relationship, the electrochemical activation of small molecules (like O<sub>2</sub>, N<sub>2,</sub> and CO<sub>2</sub>) rapidly diminishes Faradaic efficiencies with elevated current densities (particularly at ampere levels). Nevertheless, some catalysts can circumvent this... |
39757419 | Reactivity of Imidazole- and Pyridine-Carboxaldehydes for Gem-Diol and Hemiacetal Generation: Theoretical and Experimental Insights. | Gem-diols are defined as organic molecules carrying two hydroxyl groups at the same carbon atom, which is the result of the nucleophilic addition of water to a carbonyl group. In this work, the generation of the hydrated or hemiacetal forms using pyridine- and imidazole-carboxaldehyde isomers in different chemical envi... |
39757415 | Unravelling the Epitaxial Growth Mechanism of Hexagonal and Nanoporous Boron Nitride: A First-Principles Microkinetic Model. | Understanding the chemical and physical mechanisms at play in 2D materials growth is critical for effective process development of methods such as chemical vapor deposition (CVD) as a toolbox for processing more complex nanostructures and 2D materials. A combination of density functional theory and microkinetic modelin... |
39757237 | Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation. | The solubility of commonly used anti-inflammatory drugs has become a significant concern in contemporary medicine. Furthermore, inflammatory arthritis stands out as the most prevalent chronic inflammatory disease globally. The disease's pathology is characterized by heightened inflammation and oxidative stress, culmina... |
39756024 | Arrestin-independent internalization of the GLP-1 receptor is facilitated by a GRK, clathrin, and caveolae-dependent mechanism. | The glucagon-like peptide-1 receptor (GLP-1R) plays an important role in regulating insulin secretion and reducing body weight, making it a prominent target in the treatment of type 2 diabetes and obesity. Extensive research on GLP-1R signaling has provided insights into the connection between receptor function and phy... |
39756021 | Regulation of physiological and pathological condensates by molecular chaperones. | Biomolecular condensates are dynamic membraneless compartments that regulate a myriad of cellular functions. A particular type of physiological condensate called stress granules (SGs) has gained increasing interest due to its role in the cellular stress response and various diseases. SGs, composed of several hundred RN... |
39755984 | Convenient and visual ethephon detection in fruits by enhanced fluorescence of metal-organic framework. | For the first time a novel fluorescent La@ZrMOF nanomaterial was synthesized for the convenient and visual detection of ethephon (ETH) based on the ligand-metal charge transfer process. The fluorescence signal gradually enhanced as the concentration of ETH increased, accompanied by a change in the color from colorless ... |
39755956 | Metals in Motion: Understanding Labile Metal Pools in Bacteria. | Metal ions are essential for all life. In microbial cells, potassium (K<sup>+</sup>) is the most abundant cation and plays a key role in maintaining osmotic balance. Magnesium (Mg<sup>2+</sup>) is the dominant divalent cation and is required for nucleic acid structure and as an enzyme cofactor. Microbes typically requi... |
39755857 | New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract. | Chemically engineered extracts represent a promising source of new bioactive semi-synthetic molecules. Prepared through direct derivatization of natural extracts, they can include constituents enriched with elements and sub-structures that are less common in natural products compared to drugs. Fourteen such extracts we... |
39715003 | Crystal-size-dependent Optical Properties of H-atoms on the Nodes of Ti-based Metal-organic Framework. | Proton-coupled electron transfer (PCET) reactions are fundamental to energy storage and conversion processes. By coupling electrons with protons, the net charge neutrality is retained, preventing electrode decomposition due to charge imbalance. PCET reactions with equimolar amounts of protons and electrons can be consi... |
39688474 | A Pillar[5]arene-Based π-Conjugated Organic Small Molecule Emitter: Synthesis, Self-Assembly, and Selective Sensing of Cr<sub>2</sub>O<sub>7</sub> <sup>2-</sup> Anion. | A triphenylamine-containing π-conjugated pillar[5]arene luminescent small organic molecule has been synthesized via Suzuki-coupling reaction. This molecule can self-assemble to form linear supramolecular polymers in both solution and solid state. The molecule shows enhanced emission compared with parent pillar[5]arene ... |
39688070 | The Impact of Single Amino Acid Insertion on the Supramolecular Assembly Pathway of Aromatic Peptide Amphiphiles. | Understanding the mechanism of self-assembly driven by non-covalent interactions is crucial for designing supramolecular materials with desired properties. Here we investigate the self-assembly of aromatic peptide amphiphiles, Fmoc-L<sub>2</sub>QG and Fmoc-L<sub>3</sub>QG using a combination of spectroscopic, transmiss... |
39679944 | DiQuinoline-MonoQuinazoline: A Flat Proton Binder and its Application as a Polyaromatic Hydrocarbon Scavenger and G4 Ligand. | A new miniaturized framework for graphitic material featuring three neighboring pyridinic nitrogen atoms is disclosed. The quinoline/quinazoline hybridized pseudo trimeric macrocycle, DiQuinoline(Q)-MonoQuinazolines(Qz), Q2Qz1, was readily synthesized from the key macrocyclic amide precursor in a modular fashion. Its c... |
39670322 | Emissive Features of Perylene Diimide Derivative with β-Cyclodextrin: Probing the role of inter and intramolecular interactions. | Perylene diimide (PDI) derivatives have been extensively explored as chromophoric dyes for functional organic materials. Here, the custom synthesized tyrosine appended perylene diimide (PDI-Tyr) derivative has shown strong aggregation in aqueous medium diminishing its emissive features, which was surpassed by the supra... |
39656157 | Reusable Ni-Immobilized MOF Catalyst for Dehydrogenation of N-Heterocycles Under Milder Conditions. | Herein, we have demonstrated the design and synthesis of a novel Ni-immobilized MOF as heterogeneous catalyst for the dehydrogenation of N-heterocycles. A series of five and six-membered N-heteroarenes bearing one or more heteroatoms were synthesized in up to 98 % yield (>33 examples). Late stage functionalization to t... |
39654279 | Polystyrene-MOF-Derived 3D Hierarchical Porous Carbon for High-Performance Supercapacitors. | The ability to tailor surface area, porosity, and morphologies has driven extensive research into the synthesis of metal-organic frameworks derived carbons and their applications in energy storage. This study presents the development of three-dimensional hierarchically porous carbon derived from polystyrene and small-s... |
41480235 | Organic room temperature phosphorescence co-crystal with reversible acid/base stimulus response. | Stimulus-responsive organic room temperature phosphorescent (RTP) materials have received significant attention in bioimaging, sensing, and data storage because of their controllable dynamic variability and rapid response. Organic co-crystals, with tailor-designed optical properties through manipulation of their aggreg... |
40098674 | Tracking and controlling ultrafast charge and energy flow in graphene-semiconductor heterostructures. | Low-dimensional materials have left a mark on modern materials science, creating new opportunities for next-generation optoelectronic applications. Integrating disparate nanoscale building blocks into heterostructures offers the possibility of combining the advantageous features of individual components and exploring t... |
39931356 | Polymeric nanocarriers for therapeutic gene delivery. | The recent commercialization of gene products has sparked significant interest in gene therapy, necessitating efficient and precise gene delivery via various vectors. Currently, viral vectors and lipid-based nanocarriers are the predominant choices and have been extensively investigated and reviewed. Beyond these vecto... |
39896289 | Utilization of nanotechnology to surmount the blood-brain barrier in disorders of the central nervous system. | Central nervous system (CNS) diseases are a major cause of disability and death worldwide. Due to the blood-brain barrier (BBB), drug delivery for CNS diseases is extremely challenging. Nano-delivery systems can overcome the limitations of BBB to deliver drugs to the CNS, improve the ability of drugs to target the brai... |
39896283 | Crosslinker-free <i>in situ</i> hydrogel induces self-aggregation of human dental pulp stem cells with enhanced antibacterial activity. | Recently, injectable hydrogels have garnered significant attention in tissue engineering due to their controlled flowability, strong plasticity, adaptability, and good biocompatibility. However, research on readily injectable <i>in situ</i>-forming hydrogels capable of forming functional three-dimensional (3D) tissue c... |
39866794 | DNA nanotechnology-based strategies for gastric cancer diagnosis and therapy. | Gastric cancer (GC) is a formidable adversary in the field of oncology. The low early diagnosis rate of GC results in a low overall survival rate. Therefore, early accurate diagnosis and effective treatment are the key to reduce the mortality of GC. With the advent of nanotechnology, researchers continue to explore new... |
39866399 | Computational epitope-based vaccine design with bioinformatics approach; a review. | The significance of vaccine development has gained heightened importance in light of the <i>COVID-19</i> pandemic. In such critical circumstances, global citizens anticipate researchers in this field to swiftly identify a vaccine candidate to combat the pandemic's root cause. It is widely recognized that the vaccine de... |
39861853 | Two Years of SARS-CoV-2 Omicron Genomic Evolution in Brazil (2022-2024): Subvariant Tracking and Assessment of Regional Sequencing Efforts. | SARS-CoV-2, the virus responsible for COVID-19, has undergone significant genetic evolution since its emergence in 2019. This study examines the genomic diversity of SARS-CoV-2 in Brazil after the worst phase of the pandemic, the wider adoption of routine vaccination, and the abolishment of other non-pharmacological pr... |
39858455 | Synthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their Dipeptides Against <i>Aspergillus</i> Species. | In recent years, fungal infections have emerged as a significant health concern across veterinary species, especially in livestock such as cattle, where fungal diseases can result in considerable economic losses, as well as in humans. In particular, <i>Aspergillus</i> species, notably <i>Aspergillus flavus</i> and <i>A... |
39852007 | Polymer Gels Based on PAMAM Dendrimers Functionalized with Caffeic Acid for Wound-Healing Applications. | The wound-healing process has usually been related to therapeutic agents with antioxidant properties. Among them, caffeic acid, a cinnamic acid derivative, stands out. However, the use of this natural product is affected by its bioavailability and half-life. Nowadays, different approaches are being taken to improve the... |
39852006 | Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin. | In this present study, we developed and characterized a series of supramolecular G4 hydrogels by integrating <i>β</i>-cyclodextrin (<i>β</i>-CD) and boronic acid linkers into a supramolecular matrix to enhance antibacterial activity against <i>Staphylococcus aureus</i> (<i>S. aureus</i>). We systematically investigated... |
39765090 | Entropy-driven "two-way signal output" cyclic circuit: An ultra-sensitive electrochemical biosensor for non-invasive ORAOV 1 detection. | The rapid, sensitive and reliable detection of oral cancer overexpressed 1 (ORAOV 1) is crucial for the early, non-invasive diagnosis of oral squamous cell carcinoma (OSCC). Herein, we are the first to construct an ultrasensitive electrochemical (EC) biosensor based on an entropy-driven "two-way signal output" (TWSO) c... |
39761886 | Insight into the effect of ZIF-8 on the interaction between drugs and protein/cell. | Understanding the impact of nanomaterials on drug-protein/cell interactions is crucial for comprehending their in vivo biological effects. We investigated the impact of zeolitic imidazolate framework (ZIF)-8 on the interaction between curcumin (Cur) and human serum albumin (HSA) using various spectroscopic techniques a... |
39761858 | Enterobactin carries iron into Caenorhabditis elegans and mammalian intestinal cells by a mechanism independent of divalent metal transporter DMT1. | The diverse microbiota of the intestine is expected to benefit the host, yet the beneficial metabolites derived from the microbiota are still poorly understood. Enterobactin (Ent) is a well-known secreted iron-scavenging siderophore made by bacteria to fetch iron from the host or environment. Little was known about the... |
39803351 | Design of a Multiepitope Pan-Proteomic mRNA Vaccine Construct Against African Swine Fever Virus: A Reverse Vaccinology Approach. | African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious disease with devastating effects on the global pig industry. This warrants the development of effective control strategies, such as vaccines. However, previously developed inactivated vaccines have proven ineffective, while li... |
39802382 | Advancing Therapeutic Strategies with Polymeric Drug Conjugates for Nucleic Acid Delivery and Treatment. | The effective clinical translation of messenger RNA (mRNA), small interfering RNA (siRNA), and microRNA (miRNA) for therapeutic purposes hinges on the development of efficient delivery systems. Key challenges include their susceptibility to degradation, limited cellular uptake, and inefficient intracellular release. Po... |
39799631 | ZIF-67-derived NiCo<sub>2</sub>O<sub>4</sub> hollow nanocages coupled with g-C<sub>3</sub>N<sub>4</sub> nanosheets as Z-scheme photocatalysts for enhancing CO<sub>2</sub> reduction. | Photocatalytic CO<sub>2</sub> reduction technology plays a significant role in the energy and environmental sectors, highlighting the necessity for developing high-efficiency and stable catalysts. In this study, a novel photocatalyst, xNiCo<sub>2</sub>O<sub>4</sub>/CN (x = 1, 3, and 5 wt%), was synthesized by depositin... |
39796419 | Global Insights into Cultured Meat: Uncovering Production Processes, Potential Hazards, Regulatory Frameworks, and Key Challenges-A Scoping Review. | This scoping review aims to understand the cell-based meat production process, including the regulations, potential hazards, and critical points of this production. This review includes studies on cultured meat production processes, health hazards, and regulatory guidelines, excluding those without hazard analysis, inc... |
39796238 | The Molecular Biology of Placental Transport of Calcium to the Human Foetus. | From fertilisation to delivery, calcium must be transported into and within the foetoplacental unit for intracellular signalling. This requires very rapid, precisely located Ca<sup>2+</sup> transfers. In addition, from around the eighth week of gestation, increasing amounts of calcium must be routed directly from mater... |
39795235 | Recent Advances in the Tunable Optoelectromagnetic Properties of PEDOTs. | Conducting polymers represent a crucial class of functional materials with widespread applications in diverse fields. Among these, poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives have garnered significant attention due to their distinctive optical, electronic, and magnetic properties, as well as their exce... |
39795229 | Exploring the Potential of Malvidin and Echiodinin as Probable Antileishmanial Agents Through In Silico Analysis and In Vitro Efficacy. | Leishmaniasis, a neglected tropical disease caused by <i>Leishmania</i> species, presents serious public health challenges due to limited treatment options, toxicity, high costs, and drug resistance. In this study, the in vitro potential of malvidin and echioidinin is examined as antileishmanial agents against <i>L. am... |
39761900 | Computational insights into the aggregation mechanism of human calcitonin. | Human calcitonin (hCT) is a peptide hormone that regulates calcium homeostasis, but its abnormal aggregation can disrupt physiological functions and increase the risk of medullary thyroid carcinoma. To elucidate the mechanisms underlying hCT aggregation, we investigated the self-assembly dynamics of hCT segments (hCT<s... |
39755936 | Engineered MSC-sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis. | Chondrocyte senescence is an important pathogenic factor causing osteoarthritis (OA) progression through persistently producing pro-inflammatory factors. Mesenchymal stem cells-derived small extracellular vesicles (MSC-sEVs) have shown anti-inflammatory effects in OA models, while persistent existence of senescent chon... |
39755935 | End-to-End Crystal Structure Prediction from Powder X-Ray Diffraction. | Powder X-ray diffraction (PXRD) is a prevalent technique in materials characterization. While the analysis of PXRD often requires extensive human manual intervention, and most automated method only achieved at coarse-grained level. The more difficult and important task of fine-grained crystal structure prediction from ... |
39755928 | Progress in Nanotechnology for Treating Ocular Surface Chemical Injuries: Reflecting on Advances in Ophthalmology. | Ocular surface chemical injuries often result in permanent visual impairment and necessitate complex, long-term treatments. Immediate and extensive irrigation serves as the first-line intervention, followed by various therapeutic protocols applied throughout different stages of the condition. To optimize outcomes, conv... |
39755826 | Preparation of Ag-Metal organic frameworks-loaded Sodium Alginate Hydrogel for the treatment of periodontitis. | Periodontitis, a common chronic inflammatory condition caused by bacteria, leads to loss of attachment, resorption of alveolar bone, and ultimately tooth loss. Therefore, reducing bacterial load and fostering alveolar bone regeneration are essential components in the treatment of periodontitis. In this study, we prepar... |
39755818 | Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers. | Upregulation of Cyclin E1 and subsequent activation of CDK2 accelerates cell cycle progression from G1 to S phase and is a common oncogenic driver in gynecological malignancies. WEE1 kinase counteracts the effects of Cyclin E1/CDK2 activation by regulating multiple cell cycle checkpoints. Here we characterized the rela... |
39755743 | Exploring pyrazolines as potential inhibitors of NSP3-macrodomain of SARS-CoV-2: synthesis and in silico analysis. | COVID-19 has proved to be a global health crisis during the pandemic, and the emerging JN.1 variant is a potential threat. Therefore, finding alternative antivirals is of utmost priority. In the current report, we present the synthesis of new and potential anti-viral pyrazoline compounds. Here we report a chemical sche... |
39755695 | Hierarchically aligned heterogeneous core-sheath hydrogels. | Natural materials with highly oriented heterogeneous structures are often lightweight but strong, stiff but tough and durable. Such an integration of diverse incompatible mechanical properties is highly desired for man-made materials, especially weak hydrogels which are lack of high-precision structural design. Herein,... |
39755687 | Colorimetric identification of colorless acid vapors using a metal-organic framework-based sensor. | In terms of safety and emergency response, identifying hazardous gaseous acid chemicals is crucial for ensuring effective evacuation and administering proper first aid. However, current studies struggle to distinguish between different acid vapors and remain in the early stages of development. In this study, we propose... |
39755678 | Spontaneous base flipping helps drive Nsp15's preferences in double stranded RNA substrates. | Coronaviruses evade detection by the host immune system with the help of the endoribonuclease Nsp15, which regulates levels of viral double stranded RNA by cleaving 3' of uridine (U). While prior structural data shows that to cleave double stranded RNA, Nsp15's target U must be flipped out of the helix, it is not yet u... |
39755643 | From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy. | In the past decades, Chimeric Antigen Receptor (CAR)-T cell therapy has achieved remarkable success, leading to the approval of six therapeutic products for haematological malignancies. Recently, the therapeutic potential of this therapy has also been demonstrated in non-tumoral diseases. Currently, the manufacturing p... |
39754725 | A Novel Protein NLRP12-119aa that Prevents Rhabdovirus Replication by Disrupting the RNP Complex Formation. | The accurate assembly of the ribonucleoprotein (RNP) complex is fundamental for the replication and transcription of rhabdoviruses, which are known for their broad pathogenic impact. A novel 119-amino-acid protein, NLRP12-119aa is identified, encoded by the circular RNA circNLRP12, that effectively disrupts the formati... |
39754590 | 3D Printing Organogels with Bioderived Cyrene for High-Resolution Customized Hydrogel Structures. | 3D printing techniques are increasingly being explored to produce hydrogels, versatile materials with a wide range of applications. While photopolymerization-based 3D printing can produce customized hydrogel shapes and intricate structures, its reliance on rigid printing conditions limits material properties compared t... |
39754561 | Imidazole-Functionalized Zn-MOFs for One-Step C<sub>2</sub>H<sub>4</sub> Purification from C<sub>2</sub>H<sub>2</sub>/C<sub>2</sub>H<sub>4</sub>/C<sub>2</sub>H<sub>6</sub> Ternary Mixture. | The discovery of new structures is very important for metal-organic framework (MOF) adsorbents and their application in gas separation, where the design of ligands and the selection of metal ions play a decisive role. Herein, we synthesized two isoreticular Zn-MOFs, UPC-250 and UPC-251, composed of imidazole-based tric... |
39715011 | Ferrocene-Based Metal-Organic Framework for Adsorption and Degradation of Antibiotics. | Antibiotics have emerged as a significant class of organic pollutants, posing serious global challenges to both the environment and human health. To address the issue of water pollution by antibiotics, a ferrocene-based organic framework (FcMOF) with paramagnetism has been synthesized by hydrothermal complexation of fe... |
41635304 | Computational optimization of a pan-coronavirus fusion inhibitory peptide targeting spike's heptapeptide repeat region. | In the past two decades, highly pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have constituted a grave threat to human health. Broad-spectrum an... |
40735031 | Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury. | Cholesterol (CH) plays a crucial role in enhancing the membrane stability of drug delivery systems (DDS). However, its association with conditions such as hyperlipidemia often leads to criticism, overshadowing its influence on the biological effects of formulations. In this study, we reevaluated the delivery effect of ... |
40395343 | Regulating Adsorption Behaviors in Crystalline Porous Materials by External Electric Fields. | The regulation of adsorption behaviors in crystalline porous materials (CPMs) using external electric fields (E-fields) is an emerging field. CPMs are highly valued for their large surface area, well-ordered pore structures, and chemical versatility, making them ideal for applications in adsorption/separation, catalysi... |
40370540 | BRD4 regulates m<sup>6</sup>A of ESPL1 mRNA <i>via</i> interaction with ALKBH5 to modulate breast cancer progression. | The interaction between m<sup>6</sup>A-methylated RNA and chromatin modification remains largely unknown. We found that targeted inhibition of bromodomain-containing protein 4 (BRD4) by siRNA or its inhibitor (JQ1) significantly decreases mRNA m<sup>6</sup>A levels and suppresses the malignancy of breast cancer (BC) ce... |
40297741 | Robustness and Sensitivity of Gd(III)-Gd(III) Double Electron-Electron Resonance (DEER) Measurements: Comparative Study of High-Frequency EPR Spectrometer Designs and Spin Label Variants. | In this paper, we explore the robustness and sensitivity of Gd(III)-Gd(III) double electron-electron resonance (DEER) distance measurements in proteins for different spectrometer designs and three spin labels. To do this a protein was labeled at the same two positions with Gd(III) spin labels and measurements were perf... |
40161888 | Natural polymer derivative-based pH-responsive nanoformulations with entrapped diketo-tautomers of 5-fluorouracil for enhanced cancer therapy. | <h4>Background and purpose</h4>Despite significant advancements in cancer therapies, chemotherapeutics continue to be the mainstay for treating cancer patients, with 5-fluorouracil (5-FU) being commonly used for various cancers. However, its limited ability to penetrate cell membranes and its short half-life, caused by... |
40061135 | Herbal based nanoparticles as a possible and potential treatment of cancer: a review. | Cancer is the greatest cause of mortality worldwide. Various drug classes treat various cancers. Nanoformulations made from natural sources are being studied for treating several diseases, including cancer. Surgery, chemotherapy, immunotherapy, and radiation have mostly failed to treat cancer. These drugs may damage qu... |
39967907 | A review on the role of nanoparticles for targeted brain drug delivery: synthesis, characterization, and applications. | Unfortunately, nowadays, brain disorders, which include both neurological and mental disorders, are the main cause of years spent living with a disability worldwide. There are serious diseases with a high prevalence and a high mortality rate. However, the outmoded technical infrastructure makes their treatment difficul... |
39927391 | Syntheses and structures of two coordination polymers formed by Ni(cyclam)<sup>2+</sup> cations and sulfate anions. | The asymmetric units of <i>catena</i>-poly[[(1,4,8,11-tetra-aza-cyclo-tetra-decane-κ<sup>4</sup> <i>N</i> <sup>1</sup>,<i>N</i> <sup>4</sup>,<i>N</i> <sup>8</sup>,<i>N</i> <sup>11</sup>)nickel(II)]-μ<sub>2</sub>-sulfato-κ<sup>2</sup> <i>O</i> <sup>3</sup>:<i>O</i> <sup>4</sup>], [Ni(SO<sub>4</sub>)(C<sub>10</sub>H<sub>... |
39867217 | Effects of glutathione on the physicochemical properties of high hydrostatically pressure gelatinized maize starch. | This research prepared gelatinized waxy maize starch (WMS), low-amylose maize starch (LAS), and high-amylose maize starch (HAS) with different glutathione (GSH) content (5, 10, and 15 %) using high hydrostatic pressure (HHP) at 600 MPa. Scanning electron microscopy (SEM) revealed damaged morphology of WMS and complete ... |
39866789 | Recent development of micro-nano carriers for oral antineoplastic drug delivery. | Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral administration stands as the prevailing and widely utilized method of delivering chemotherapy drugs. However, the majority... |
39866779 | Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma. | Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and a poor prognosis. The blood-brain barrier (BBB) and the blood-tumor barrier (BTB) present significant obstacles to the efficacy of tumor-targeted pharmacotherapy, thereby impeding the therapeutic potential... |
39861704 | Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research. | Psoriasis, a chronic inflammatory dermatosis, represents a significant clinical challenge due to its complex pathogenesis and the limitations of existing therapeutic strategies. Current psoriasis diagnoses are primarily clinician-dependent, with instrumental diagnostics serving as adjuncts. Ongoing research is progress... |
39861702 | Cutting-Edge Advances in Anticancer Therapies: Insights from the Third Edition of the Special Issue "Novel Anticancer Strategies". | Cancer incidence and mortality continue to rise at an alarming rate worldwide, underscoring the urgent need for more effective therapeutic interventions [...]. |
39861701 | Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability. | Resins are complex mixtures of natural constituents containing non-volatile and volatile terpenes, in combination with gums and polyphenols, used since ancient times for their medicinal properties. Current research has evidenced their therapeutic value with a plethora of activities. The main limits of resins and their ... |
39857383 | Prominent Naturally Derived Oxidative-Stress-Targeting Drugs and Their Applications in Cancer Treatment. | The relationship between oxidative stress and cancer has been extensively studied and highlighted, along with its role in various aspects of angiogenesis. The modulation of oxidative levels and the adaptive mechanisms of oxidative stress in cancer systems are attractive research themes for developing anti-cancer strate... |
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