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39852358 | Serum Uric Acid and Bone Health in Middle-Aged and Elderly Hypertensive Patients: A Potential U-Shaped Association and Implications for Future Fracture Risk. | <h4>Background</h4>The influence of serum uric acid (SUA) on bone metabolism, as suggested by previous studies, remains a contentious issue. SUA plays a complex role in bone health and hypertension, making it challenging to discern its impact on the skeletal status of middle-aged and elderly hypertensive patients. This... |
39851741 | Nanotherapeutics for Meningitis: Enhancing Drug Delivery Across the Blood-Brain Barrier. | Meningitis is the acute or chronic inflammation of the protective membranes, surrounding the brain and spinal cord, and this inflammatory process spreads throughout the subarachnoid space. The traditional drug delivery methods pose a disadvantage in limiting the capacity of crossing the blood-brain barrier (BBB) to rea... |
39832872 | Photo-induced multiple charge transfer resonance of Ce-MOF for SERS detection of nucleic acid. | <h4>Background</h4>Sensitive and accurate detection of important cancer markers MicroRNAs (miRNAs) is critical to prevent and treat disease. Among many detection techniques, surface-enhanced Raman scattering(SERS) has attracted much attention due to its advantages such as narrow spectral peak, low interference and non-... |
39831115 | SPD_0410 negatively regulates capsule polysaccharide synthesis and virulence in <i>Streptococcus pneumoniae</i> D39. | <i>Streptococcus pneumoniae</i> capsular polysaccharide (CPS) is a crucial virulence factor for this pathogenic bacterium and is partially under transcriptional control. In this study, we used electrophoretic mobility shift assays and DNA enzyme footprinting to identified the hypothetical protein SPD_0410 as a negative... |
39830981 | Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis. | <h4>Introduction</h4>Extensive efforts have been made to explore members of the IL-10 family as potential therapeutic strategies for various diseases; however, their biological role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains underexplored.<h4>Methods</h4>Gene expression datasets GSE136825, GSE179265, ... |
39830517 | A self-assembled nanoparticle vaccine elicits effective neutralizing antibody response against EBV infection. | <h4>Background</h4>Epstein-Barr virus (EBV) is a significant global public health concern because of its association with various malignancies and autoimmune diseases. Over 90% of the global population is chronically infected with EBV, impacting numerous cancer-related cases annually. However, none of the effective pro... |
39830336 | Dihydromyricetin: an emerging compound with comprehensive effects on multiple systems. | Dihydromyricetin (DHM or DMY) is a flavonoid derived from natural sources with a range of confirmed biological benefits. It exhibits anti-inflammatory, antioxidant, anti-tumor, and anti-viral activities. DHM is recognized for its high biosafety, making it a promising subject for further research. This article offers a ... |
39829510 | Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study. | Manufacturing bioactive materials for drug delivery involves developing materials that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is to optimize therapeutic efficacy and reduce side effects by combining knowledge from materials engineering, biology, and pharmacology.... |
39765091 | Detection of zearalenone by electrochemical aptasensor based on enzyme-assisted target recycling and DNAzyme release strategy. | Zearalenone has a high level of detection and exceedance in cereals and by-products. Herein, an electrochemical aptasensor for ZEN detection was proposed. The selected aptamer, which has a high affinity for ZEN, serves as a molecular recognition element and effectively avoids interference from other toxins. Meanwhile, ... |
39764988 | Molecule self-assembly of hydrangea-shaped hollow O, Cl -codoped graphite-phase carbon nitride microspheres for efficient N-(1,3-dimethyl butyl)-N'-phenyl-p-phenylenediamine quinone photodegradation and bacteria disinfection. | 6PPD-quinone (6PPD-Q) as a derivative of the rubber antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), is attracting intensive attention due to the significant hazard to ecosystems. However, the effective management of this type of contaminant has been scarcely reported. Hydrangea-like hollow O, Cl-... |
39764980 | Ultrasensitive platform for the determination of biothiols using aggregation-induced emission of gold-cysteine nanosheets. | Highly ordered ultrathin nanosheets (NSs) of Au(I)-Cys were fabricated through aggregation-induced supramolecular self-assembly triggered by an extended agitation in an alkaline environment. The synthesized Au(I)-Cys NSs exhibited intense luminescence and exceptional chirality. Remarkably, additions of biothiols to Au(... |
39764561 | Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus. | Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that is primarily known for causing severe joint and muscle symptoms, but its pathological effects have extended beyond these tissues. In this study, we conducted a comprehensive proteomic analysis across various organs in rodent and nonhuman primate models to in... |
39803352 | Molecular Characterization of Bovine <i>Deltapapillomavirus</i> in Equine Sarcoids in Egypt. | Bovine papillomaviruses (BPVs) commonly cause sarcoids in equines worldwide. Equine sarcoids (ESs) reduce the working ability of draft animals and produce untoward cosmetic changes in racing and dancing equine. In this study, nine horses and 16 donkeys with sarcoids were presented to Zagazig University Veterinary Clini... |
39795380 | Antifungal Activity of Genistein Against Phytopathogenic Fungi <i>Valsa mali</i> Through ROS-Mediated Lipid Peroxidation. | <i>Valsa mali</i> (<i>V. mali</i>) is a necrotrophic fungus responsible for apple Valsa canker, which significantly diminishes apple production yields and quality in China. Our serendipitous findings revealed that genistein significantly inhibits the mycelial growth of <i>V. mali</i>, with an inhibition rate reaching 4... |
39795375 | Enhanced Phytoextraction Technologies for the Sustainable Remediation of Cadmium-Contaminated Soil Based on Hyperaccumulators-A Review. | Heavy metal pollution in soil is a significant challenge around the world, particularly cadmium (Cd) contamination. In situ phytoextraction and remediation technology, particularly focusing on Cd hyperaccumulator plants, has proven to be an effective method for cleaning Cd-contaminated agricultural lands. However, this... |
39795215 | Bluues_cplx: Electrostatics at Protein-Protein and Protein-Ligand Interfaces. | (1) Background: Electrostatics plays a capital role in protein-protein and protein-ligand interactions. Implicit solvent models are widely used to describe electrostatics and complementarity at interfaces. Electrostatic complementarity at the interface is not trivial, involving surface potentials rather than the charge... |
39795217 | Electromigration Techniques in the Analysis of Selected Cosmetic Ingredients: A Review. | The cosmetics industry is one of the fastest-growing sectors worldwide. The dynamic evolution of this industry results in an increasingly diverse range of products containing various active ingredients. Ensuring the quality of these products is crucial for consumer safety, necessitating the use of advanced analytical m... |
39793209 | PAMAM/miR-144 nanocarrier system inhibits the migration of gastric cancer by targeting mTOR signal transduction pathway. | Exogenous microRNA-144 (miR-144) is considered as a potential biological drug for gastric cancer because of its biological activity to inhibit the epithelial-mesenchymal transition (EMT). However, the specific molecular mechanisms have not been fully revealed. In addition, their vulnerability to degradation by RNA enzy... |
39778394 | Supramolecular phosphorescent assemblies based on cucurbit[8]uril and bromophenylpyridine derivatives for dazomet recognition. | A bromophenylpyridine derivative (N1) was designed, synthesized, and the molecule was incorporated into the cavity of the cucurbit[8]uril (Q[8]) as a guest to form a 2:1 host-guest complex. This complex demonstrates good room temperature phosphorescence (RTP) properties in aqueous solution. The host-guest interaction a... |
39760004 | Nanoformulated phytochemicals in skin anti-aging research: an updated mini review. | Skin aging is characterized by progressive loss of functionality and regenerative potential of the skin, resulting in the appearance of wrinkles, irregular pigmentation, a decrease of elasticity, dryness, and rough texture. Damage to the skin caused by oxidative stress could substantially be slowed down by the use of p... |
39759928 | A comprehensive approach for elucidating the interplay between 4f <sup><i>n</i>+1</sup> and 4f <sup><i>n</i></sup> 5d<sup>1</sup> configurations in Ln<sup>2+</sup> complexes. | Lanthanides (Ln) are typically found in the +3 oxidation state. However, in recent decades, their chemistry has been expanded to include the less stable +2 oxidation state across the entire series except promethium (Pm), facilitated by the coordination of ligands such as trimethylsilylcyclopentadienyl, C<sub>5</sub>H<s... |
39759542 | Titanium dioxide nanoparticles: a promising candidate for wound healing applications. | Effective wound management and treatment are crucial in clinical practice, yet existing strategies often fall short in fully addressing the complexities of skin wound healing. Recent advancements in tissue engineering have introduced innovative approaches, particularly through the use of nanobiomaterials, to enhance th... |
39758968 | Partial cystectomy as a surgical option for colorectal cancer patients with pathological bladder invasion: an original retrospective study. | <h4>Background</h4>Limited research exists on colorectal cancer (CRC) patients with bladder invasion, with survival outcomes post-cystectomy underexplored and a debate between partial and total cystectomy ongoing.<h4>Objective</h4>The study aimed to evaluate the effect of pathological bladder invasion on the long-term ... |
39758925 | Design, characterization, and <i>in vitro</i> evaluation of magnetic carboxymethylated β-cyclodextrin as a pH-sensitive carrier system for amantadine delivery: a novel approach for targeted drug delivery. | In this study, a magnetic carboxymethylated β-cyclodextrin (Mag/CM-β-CD) was developed as a carrier system to assess its capability on drug delivery application by forming an inclusion complex with amantadine (Amn) as a drug model. The synthesized inclusion complex (Mag/CM-β-CD/Amn) was analyzed using various technique... |
39758919 | Polypyrrole functionalized MoS<sub>2</sub> for sensitive and simultaneous determination of heavy metal ions in water. | Assessing heavy metal ion (HMI) contamination to sustain drinking water hygiene is a challenge. Conventional approaches are appealing for the detection of HMIs but electrochemical approaches can resolve the limitations of these approaches, such as tedious sample preparation, high cost, time consuming and the need for t... |
39758914 | Imidazolium-based ionic liquid functionalized chiral metal-organic framework as an efficient catalyst for asymmetric catalytic sulfoxidation. | Ionic liquid (IL) units in heterogeneous catalysts exhibit synergistic effects to enhance catalytic performance and stabilize catalytically active centers, while also preventing the degradation of catalysts during the reaction process. Ionic liquid units in IL-functionalized CMOF catalysts enhance their catalytic perfo... |
39758907 | Electrochemically embedded heterostructured Ni/NiS anchored onto carbon paper as bifunctional electrocatalysts for urea oxidation and hydrogen evolution reaction. | Developing high-efficiency, cost-effective, and long-term stable nanostructured catalysts for electrocatalytic water splitting remains one of the most challenging aspects of hydrogen fuel production. Urea electrooxidation reaction (UOR) can produce hydrogen energy from nitrogen-rich wastewater, making it a more sustain... |
39758905 | Ethylenediamine assist preparation of carbon dots with novel biomass for highly sensitive detection of levodopa. | Levodopa (l-Dopa), a precursor drug for dopamine has been widely used to treat Parkinson's disease. However, excess accumulation of l-Dopa in the body may cause movement disorders and uncontrollable emotions. Therefore, it is vital to monitor l-Dopa levels in patients. In this study, a carbon dot (CD)-based fluorescenc... |
39756762 | Molecular recognition of the promoter DNA signature sequence by Hms1p<sup>DBD</sup>. | Transcriptional regulation of sterol biosynthetic genes is mediated by conserved sterol-regulatory element binding proteins (SREBPs) in human pathogenic fungi, however, its homolog in S. cerevisiae regulate filamentous growth during stress conditions. These pseudohyphal growths might be associated with the expression o... |
39756750 | Deferoxamine-loaded gelatin methacryloyl hydrogel endue 3D-printed PGCL-hydroxyapatite scaffold with angiogenesis, anti-oxidative and immunoregulatory capacities for facilitating bone healing. | Promoting angiogenesis, alleviating oxidative stress injury and inflammation response are crucial for bone healing. Herein, the deferoxamine (DFO)-loaded gelatin methacryloyl (GelMA) hydrogel coating (GelMA-DFO) was constructed on the 3D-printed poly(Glycolide-Co-Caprolactone)-hydroxyapatite (PGCL-HAP) scaffold. After ... |
39756736 | Efficient Hg<sup>2+</sup> adsorption using a silk fibroin/MOF-2/alginate composite: Kinetics and thermodynamics. | The effective adsorption of (mercuric ions) Hg<sup>2+</sup> onto synthesized and characterized composite materials based on calcium alginate (CG), zinc metal-organic farmwork (MOF-2), and silk fibroin powder (SF) has been reported in this study. Under various application conditions, the adsorption capacities of silk fi... |
39756732 | Effect of isoflavone structures on the formation of starch-isoflavone complexes: Experimental and molecular dynamics analysis. | Isoflavones were the commonly polyphenols capable of forming inclusion complexes with starch to slow starch enzymatic digestion. However, the impact of isoflavone structures on the formation of starch-isoflavone complexes was not well understood. In this study, isoflavones with distinct structurally differences, includ... |
39756721 | Near-infrared DNA-AgNCs enzyme-free fluorescence biosensing for microRNA imaging in living cells based on self-replicating catalytic hairpin self-assembly. | In this work, a fast signal amplification system mediated by self-replicating catalytic hairpin self-assembly (SCHA) was established for microRNA-155 using near-infrared DNA-Ag Nanoclusters (DNA-AgNCs) as fluorescence signal output. Among them, two fission target-like DNA sequences are merged into two hairpin DNA H1 an... |
39756599 | Supramolecular delivery systems for polyphenols: A green approach to predict in vivo permeability through an in vitro setup. | The use of in vitro markers able to reproduce the in vivo permeability and diffusivity of orally administered drugs, could represent an innovative starting point for the formulation of delivery systems, in particular for low soluble and low permeable drugs belonging to BCS class II and IV. Considering the great interes... |
39755025 | Cationic and anionic PLGA-cholesterol hybrid nanoparticles as promising platforms to enhance the trypanocidal efficacy of benznidazole and drug delivery in Trypanosoma cruzi-infected cells. | Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma cruzi, remains a significant global health challenge. Currently, benznidazole (BNZ) is the primary treatment in many countries. However, this drug is limited by low bioavailability, significant host toxicity, and reduced efficacy in chro... |
39754328 | Periodic Table of Immunomodulatory Elements and Derived Two-Dimensional Biomaterials. | Periodic table of chemical elements serves as the foundation of material chemistry, impacting human health in many different ways. It contributes to the creation, growth, and manipulation of functional metallic, ceramic, metalloid, polymeric, and carbon-based materials on and near an atomic scale. Recent nanotechnology... |
39754307 | A Crystalline 3D Supramolecular Polymer Constructed by Clamparene-Based Controllable Self-Assembly and Its Application in Photothermal Conversion. | The development of well-defined three-dimensional supramolecular polymers presents significant challenges, particularly in achieving crystalline state structures. This study addresses this challenge by presenting the construction of a crystalline three-dimensional supramolecular polymer through the self-assembly of cla... |
39754257 | Advances in 3D printing combined with tissue engineering for nerve regeneration and repair. | The repair of nerve damage has long posed a challenge owing to limited self-repair capacity and the highly differentiated nature of nerves. While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative efficacy remains limited. Tissue engineering offers a promising avenue for overc... |
39754249 | Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer. | CDK4/6i, the first-line drug for treating ERα-positive breast cancer, significantly improves clinical outcomes. However, CDK4/6i resistance often develops and remains a major hurdle, and the underlying mechanisms remain challenging to fully investigate. Here, we used Genome-wide CRISPR/Cas9 library screening combined w... |
39754239 | Universal receptive system as a novel regulator of transcriptomic activity of Staphylococcus aureus. | Our previous studies revealed the existence of a Universal Receptive System that regulates interactions between cells and their environment. This system is composed of DNA- and RNA-based Teazeled receptors (TezRs) found on the surface of prokaryotic and eukaryotic cells, as well as integrases and recombinases. In the c... |
39754217 | Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1. | <h4>Background</h4>This research aims to explore the anti-obesity potential of Wu-Mei-Wan (WMW), particularly its effects on adipose tissue regulation in obese mice induced by a high-fat diet (HFD). The study focuses on understanding the role of heat shock factor 1 (HSF1) in mediating these effects.<h4>Methods</h4>HFD-... |
39754191 | Factors associated with the dental service utilization by enrollees on the Lagos State health insurance scheme, Nigeria. | <h4>Background</h4>Despite assumptions that insurance coverage would boost oral healthcare utilization in Nigeria, there is insufficient evidence supporting this claim. This study investigates the associations between residential location, awareness of the oral health insurance scheme, history of dental service utiliza... |
39754127 | Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine. | Extracellular vesicles (EVs) are membrane-bound vesicles that are shed or secreted from the cell membrane and enveloped by a lipid bilayer. They possess stability, low immunogenicity, and non-cytotoxicity, exhibiting extensive prospects in regenerative medicine (RM). However, natural EVs pose challenges, such as insuff... |
39754051 | Epigenetic modification regulates the ligamentum flavum hypertrophy through miR-335-3p/SERPINE2/β-catenin signaling pathway. | <h4>Background</h4>Epigenetic modifications have been proved to play important roles in the spinal degenerative diseases. As a type of noncoding RNA, the microRNA (miRNA) is a vital class of regulatory factor in the epigenetic modifications, while the role of miRNAs in the regulation of epigenetic modifications in liga... |
39754040 | Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospective multicenter study. | <h4>Background</h4>In China many respiratory pathogens stayed low activities amid the COVID-19 pandemic due to strict measures and controls. We here aimed to study the epidemiological and clinical characteristics of pediatric inpatients with Mycoplasma pneumoniae pneumonia (MPP) after the mandatory COVID-19 restriction... |
39754015 | Cytoskeleton-functionalized synthetic cells with life-like mechanical features and regulated membrane dynamicity. | The cytoskeleton is a crucial determinant of mammalian cell structure and function, providing mechanical resilience, supporting the cell membrane and orchestrating essential processes such as cell division and motility. Because of its fundamental role in living cells, developing a reconstituted or artificial cytoskelet... |
39753999 | Effects of LinTT1-peptide conjugation on the properties of poly(ethylene glycol)-block-(ε-caprolactone) nanoparticles prepared by the nanoprecipitation method. | Functionalization of polymer nanoparticles (NPs) with targeting peptides is of interest for drug delivery applications to enhance tumor accumulation and penetration. Herein, we evaluated the feasibility of two different methods for the attachment of a tumor-penetrating peptide LinTT1 (AKRGARSTA) to poly(ethylene glycol... |
39753954 | The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes. | The ESCRT machinery mediates membrane remodeling in numerous processes in cells including cell division and nuclear membrane reformation. The identification of ESCRT homologs in Asgard archaea, currently considered the closest prokaryotic relative of eukaryotes, implies a role for ESCRTs in the membrane remodeling proc... |
39753953 | A bipartite bacterial virulence factor targets the complement system and neutrophil activation. | The complement system and neutrophils constitute the two main pillars of the host innate immune defense against infection by bacterial pathogens. Here, we identify T-Mac, a novel virulence factor of the periodontal pathogen Treponema denticola that allows bacteria to evade both defense systems. We show that T-Mac is ex... |
39753877 | Aromatic pi-complexation of 1,5-diisocyanonaphthalene with benzene derivatives. | Aromatic π-complexes play a significant role in various chemical and biological systems, significantly influencing their physico-chemical and spectroscopic properties. The identification of new compounds capable of π-complex formation is therefore of great interest. The paper investigates the fluorescent properties of ... |
39753812 | Production of Oncorhynchus mykiss biosensor based on polyvinyl alcohol/chitosan nanocomposite using phycocyanin during refrigerated storage. | Smart packaging, also known as intelligent packaging, is responsive to external stimuli, moisture, light, oxygen, heat, pH, and bacterial growth. In this study, polyvinyl alcohol/nanochitosan/phycocyanin nanocomposite (PVA/NCH/PC-NC) for fish fillets of Oncorhynchus mykiss rainbow trout coating was prepared. Five treat... |
39753790 | Investigating the link between a layer thickness and surface relief depth in an azo poly(ether imide). | Surface relief grating formation in photo-responsive azo polymers under irradiation is a long-ago-found phenomenon, but all the factors governing its efficiency are still not fully recognized. Here, we report on the enormous impact of the polymer thickness on the possibility of fabrication of extremely high-amplitude s... |
39753777 | Interfacial water confers transcription factors with dinucleotide specificity. | Transcription factors (TFs) recognize specific bases within their DNA-binding motifs, with each base contributing nearly independently to total binding energy. However, the energetic contributions of particular dinucleotides can deviate strongly from the additive approximation, indicating that some TFs can specifically... |
39753625 | Discovery of potent anti-toxoplasmosis drugs from secondary metabolites in Citrus limon (lemon) leaves, supported in-silico study. | Toxoplasmosis induced by Toxoplasma gondii is a well-known health threat, that prompts fatal encephalitis increased with immunocompromised patients, in addition, it can cause chorioretinitis, microcephaly, stillbirth in the fetus and even led to death. Standard therapy uses sulfadiazine and pyrimethamine drugs revealed... |
39753604 | Synthesis and crystal structure of piperidinyl propanenitrile towards the preparation of piperidine based bioactive films for drug delivery applications. | Compounds containing the piperidine group are highly attractive as building blocks for designing new drugs. Functionalized piperidines are of significant interest due to their prevalence in the pharmaceutical field. Herein, 3-oxo-3-(piperidin-1-yl) propanenitrile has been synthesized, and piperidine-based sodium algina... |
39753586 | Pharmacological properties of biomimetic synthesized silver nanoparticles from endophytic fungus Coniothyrium chaingmaiense: KUMBMDBT-25. | In this study, the endophytic fungus Coniothyrium chaingmaiense-KUMBMDBT-25 was isolated from the healthy stem of Euphorbia tirucalli, mass cultivated by submerged fermentation, and extracted using ethyl acetate as a solvent. The extract was subjected to GC-MS analysis. The synthesized Con-AgNPs were characterized thro... |
39753569 | A membrane permeability database for nonpeptidic macrocycles. | The process of developing new drugs is arduous and costly, particularly for targets classified as "difficult-to-drug." Macrocycles show a particular ability to modulate difficult-to-drug targets, including protein-protein interactions, while still allowing oral administration. However, the determination of membrane per... |
39753560 | Ionizable polymeric micelles (IPMs) for efficient siRNA delivery. | Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance (ABC) effect. We design three ionizable oligomers (IOs) that, with polylactide-polyethylene glycol (PLA-PEG), form a potential siRNA delivery system, named Ionizable Polymeric ... |
39753538 | Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS). | Mitochondrial function is modulated by its interaction with the endoplasmic reticulum (ER). Recent research indicates that these contacts are disrupted in familial models of amyotrophic lateral sclerosis (ALS). We report here that this impairment in the crosstalk between mitochondria and the ER impedes the use of gluco... |
39753533 | Entropy engineering activation of UiO-66 for boosting catalytic transfer hydrogenation. | High-entropy metal-organic frameworks (HE-MOFs) hold promise as versatile materials, yet current rare examples are confined to low-valence elements in the fourth period, constraining their design and optimization for diverse applications. Here, a novel high-entropy, defect-rich and small-sized (32 nm) UiO-66 (ZrHfCeSnT... |
39752641 | Controlling the Spatiotemporal Self-Organization of Stimuli-Responsive Nanocrystals under Out-of-Equilibrium Conditions. | Self-organization under out-of-equilibrium conditions is ubiquitous in natural systems for the generation of hierarchical solid-state patterns of complex structures with intricate properties. Efforts in applying this strategy to synthetic materials that mimic biological function have resulted in remarkable demonstratio... |
39752624 | Biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks: degenerating parasite-specific hyperparasite catalysts confer parasite resistance and herald the birth of molecular immunity. | Catalysis and specifically autocatalysis are the quintessential building blocks of life. Yet, although autocatalytic networks are necessary, they are not sufficient for the emergence of life-like properties, such as replication and adaptation. The ultimate and potentially fatal threat faced by molecular replicators is ... |
39752607 | Smartphone-Assisted Fluorescence Determination of Inorganic Phosphorus Using a Samarium Metal-Organic Framework. | Inorganic phosphori are widely used in food, whose quantitative detection method is of significance. This work presents a Sm-DDB (H<sub>4</sub>DDB = 1,3-di(3',5'-dicarboxylphenyl)benzene), which acts as a ratiometric fluorescence sensor to monitor PO<sub>4</sub><sup>3-</sup>, H<sub>2</sub>PO<sub>4</sub><sup>-</sup>, an... |
39752602 | Supramolecular Entrapping and Extraction of Selenate, Molybdate and Tungstate Ions from Water by Nanojars. | The supramolecular binding exclusively by H-bonds of SeO<sub>4</sub><sup>2-</sup>, MoO<sub>4</sub><sup>2-</sup> and WO<sub>4</sub><sup>2-</sup> ions to form nanojars of the formula [EO<sub>4</sub><sup>2-</sup>⊂{<i>cis</i>-Cu<sup>II</sup>(μ-OH)(μ-pz)}<sub><i>n</i></sub>]<sup>2-</sup> (<b>Cu</b><sub><b><i>n</i></b></sub>... |
39752569 | Glutathione-Responsive Metal-Organic-Framework-Derived Mn<sub><i>x</i></sub>O<sub><i>y</i></sub>/(A/R)TiO<sub>2</sub> Nanoparticles for Enhanced Synergistic Sonodynamic/Chemodynamic/Immunotherapy. | Despite the potential of sonodynamic therapy (SDT) in treating malignant tumors, the lack of effective sonosensitizers has limited its clinical implementation. In this study, we explored the relationship between the heteroatom doping concentration in metal-organic frameworks and interface formation after pyrolysis by r... |
39752537 | NEK7 phosphorylation amplifies NLRP3 inflammasome activation downstream of potassium efflux and gasdermin D. | The NLRP3 inflammasome plays a critical role in innate immunity and inflammatory diseases. NIMA-related kinase 7 (NEK7) is essential for inflammasome activation, and its interaction with NLRP3 is enhanced by K<sup>+</sup> efflux. However, the mechanism by which K<sup>+</sup> efflux promotes this interaction remains unk... |
39752485 | Treating myocardial infarction via a nano-ultrasonic contrast agent-mediated high-efficiency drug delivery system targeting macrophages. | Following myocardial infarction (MI), the accumulation of CD86-positive macrophages in the ischemic injury zone leads to secondary myocardial damage. Precise pharmacological intervention targeting this process remains challenging. This study engineered a nanotherapeutic delivery system with CD86-positive macrophage-spe... |
39752417 | The omicron variant of SARS-CoV-2 drove broadly increased seroprevalence in a public university setting. | Omicron is the comparatively most transmissible and contagious variant of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). We conducted a seroprevalence study from March 1-3, 2022, to investigate the seroprevalence of SARS-CoV-2 antibodies among individuals aged 18 years and older after the Omicron outbrea... |
39752369 | Progress in antileishmanial drugs: Mechanisms, challenges, and prospects. | Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, continues to pose global health challenges. Current treatments face issues like resistance, safety, efficacy, and cost. This review covers the discovery, mechanisms of action, clinical applications, and limitations of key antileishmanial agents... |
39752339 | Molecular dynamics simulation based prediction of T-cell epitopes for the production of effector molecules for liver cancer immunotherapy. | Liver cancer is the sixth most frequent malignancy and the fourth major cause of deaths worldwide. The current treatments are only effective in early stages of cancer. To overcome the therapeutic challenges and exploration of immunotherapeutic options, broad spectral therapeutic vaccines could have significant impact. ... |
39752295 | PM6-ML: The Synergy of Semiempirical Quantum Chemistry and Machine Learning Transformed into a Practical Computational Method. | Machine learning (ML) methods offer a promising route to the construction of universal molecular potentials with high accuracy and low computational cost. It is becoming evident that integrating physical principles into these models, or utilizing them in a Δ-ML scheme, significantly enhances their robustness and transf... |
39752277 | Precise Preparation of Size-Uniform Two-Dimensional Platelet Micelles Through Crystallization-Assisted Rapid Microphase Separation Using All-Bottlebrush-Type Block Copolymers with Crystalline Side Chains. | Polymer nanoparticles with low curvature, especially two-dimensional (2D) soft materials, are rich in functions and outstanding properties and have received extensive attention. Crystallization-driven self-assembly (CDSA) of linear semicrystalline block copolymers is currently a common method of constructing 2D platele... |
39752260 | Genetically Engineered, Multichromophore Virus-Like Nanoparticles with Ultranarrow Distribution of Emission Intensity. | Variance in the properties of optical mesoscopic probes is often a limiting factor in applications. In the thermodynamic limit, the smaller the probe, the larger the relative variance. However, specific viral protein cages can assemble efficiently outside the bounds of statistical fluctuations at equilibrium through a ... |
39752259 | Site-Selective Copper(I)-Catalyzed Hydrogenation of Amides. | We present a bifunctional catalyst consisting of a copper(I)/N-heterocyclic carbene and an organocatalytic guanidine moiety that enables, for the first time, a copper(I)-catalyzed reduction of amides with H<sub>2</sub> as the terminal reducing agent. The guanidine allows for reactivity tuning of the originally weakly n... |
39752231 | Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis. | Ovarian cancer is the leading cause of death among all gynecological malignancies, and drug resistance renders the current chemotherapy agents ineffective for patients with advanced metastatic tumors. We report an effective treatment strategy for targeting metastatic ovarian cancer involving a nanoformulation (Bola/IM)... |
39751975 | Laser speckle contrast imaging with principal component and entropy analysis: a novel approach for depth-independent blood flow assessment. | Current study presents an advanced method for improving the visualization of subsurface blood vessels using laser speckle contrast imaging (LSCI), enhanced through principal component analysis (PCA) filtering. By combining LSCI and laser speckle entropy imaging with PCA filtering, the method effectively separates stati... |
39751924 | Smartphone-integrated colorimetric sensor for rapid detection of phenolic compounds based on the peroxidase-mimicking activity of copper/cerium-aspartic acid metal-organic framework. | A smartphone-integrated colorimetric sensor is introduced for the rapid detection of phenolic compounds, including 8-hydroquinone (HQ), p-nitrophenol (NP), and catechol (CC). This sensor relies on the peroxidase-mimicking activity of aspartate-based metal-organic frameworks (MOFs) such as Cu-Asp, Ce-Asp, and Cu/Ce-Asp.... |
39751905 | Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle. | Little is known about how distance between homologous chromosomes are controlled during the cell cycle. Here, we show that the distribution of centromere components display two discrete clusters placed to either side of the centrosome and apical/basal axis from prophase to G<sub>1</sub> interphase. 4-Dimensional live c... |
39751380 | Diversity in Notch ligand-receptor signaling interactions. | The Notch signaling pathway uses families of ligands and receptors to transmit signals to nearby cells. These components are expressed in diverse combinations in different cell types, interact in a many-to-many fashion, both within the same cell (in cis) and between cells (in trans), and their interactions are modulate... |
39750508 | The Road Ahead for Metal-Organic Frameworks: Current Landscape, Challenges and Future Prospects. | This perspective highlights the transformative potential of Metal-Organic Frameworks (MOFs) in environmental and healthcare sectors. It discusses work that has advanced beyond technology readiness levels of >4 including applications in capture, storage, and conversion of gases to value added products. This work showcas... |
39750115 | Metal-Organic Frameworks with Phosphonate Monoester Linkers for Catalytic C(sp<sup>2</sup>)-H Borylation of Alkenes. | An isoreticular metal-organic framework (MOF) series was constructed from nickel or cobalt nodes, phosphonate monoester, and bipyridine linkers. The cobalt-containing MOFs were found to catalyze the dehydrogenative C-H borylation of alkenes under mild conditions. This process selectively generates vinyl boronate withou... |
39749991 | Heteropolyacid Ligands in Two-Dimensional Channels Enable Lithium Separation from Monovalent Cations. | Extracting lithium from salt lakes requires ion-selective membranes with customizable nanochannels. However, it remains a major challenge to separate alkali cations due to their same valences and similar ionic radius. Inspired by the K<sup>+</sup> channel of KcsA K<sup>+</sup>, significant progress has been made in adj... |
39749973 | Small molecules targeting the eubacterial β-sliding clamp discovered by combined <i>in silico</i> and <i>in vitro</i> screening approaches. | Antibiotic resistance stands as the foremost post-pandemic threat to public health. The urgent need for new, effective antibacterial treatments is evident. Protein-protein interactions (PPIs), owing to their pivotal role in microbial physiology, emerge as novel and attractive targets. Particularly promising is the α-su... |
39749961 | Quick-and-Easy Validation of Protein-Ligand Binding Models Using Fragment-Based Semiempirical Quantum Chemistry. | Electronic structure calculations in enzymes converge very slowly with respect to the size of the model region that is described using quantum mechanics (QM), requiring hundreds of atoms to obtain converged results and exhibiting substantial sensitivity (at least in smaller models) to which amino acids are included in ... |
39749880 | Imaging malaria parasites across scales and time. | The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology. Since the discovery of the Plasmod... |
39749835 | A Single Bioorthogonal Reaction for Multiplex Cell Surface Protein Labeling. | Small-molecule fluorophores are invaluable tools for fluorescence imaging. However, means for their covalent conjugation to the target proteins limit applications in multicolor imaging. Here, we identify 2-[(alkyl<b>t</b>hio)(<b>a</b>ryl)<b>m</b>ethylene]<b>m</b>alononitrile (TAMM) molecules reacting with 1,2-aminothio... |
39749782 | Aptasensor-based point-of-care detection of cardiac troponin biomarkers for diagnosis of acute myocardial infarction. | Acute myocardial infarction (AMI) represents a critical health challenge characterized by a significant reduction in blood flow to the heart, leading to high rates of mortality and morbidity. Cardiac troponins, specifically cardiac troponin I and cardiac troponin T, are essential proteins involved in cardiac muscle con... |
39749773 | Competing Hexagonal and Square Lattices on a Spherical Surface. | The structural properties of packed soft-core particles provide a platform to understand the cross-pollinated physical concepts in solid-state and soft-matter physics. Confined on a spherical surface, the traditional differential geometry also dictates the overall defect properties in otherwise regular crystal lattices... |
39749653 | Designing Hybrid Plasmonic Superlattices with Spatially Confined Responsive Heterostructural Units. | Plasmonic superlattices enable the precise manipulation of electromagnetic fields at the nanoscale. However, the optical properties of static lattices are dictated by their geometry and cannot be reconfigured. Here, we present a surface-interface engineered plasmonic superlattice with confined polyelectrolyte-functiona... |
39749636 | Photothermal Effect and Biomineralization of Black Phosphorus Nanosheet-Composited Hydrogel Boosts Synergistic Treatment of Dentin Hypersensitivity. | Dentin hypersensitivity (DH), marked by exposed dentinal tubules, presents as a sharp toothache triggered by stimuli and subsides when the stimuli are removed. To address the limitations of current commercial desensitizers in terms of acid resistance, friction resistance, and stability, a black phosphorus nanosheet-com... |
39749400 | Conformational Selectivity and Chiral Self-Assembly Structures of Crown Ethers on Metal Surfaces. | Crown ethers (CEs), macrocyclic polyethers, have attracted significant attention in supramolecular chemistry. It is known that they have many isomers due to their flexibility. It is challenging to select some exact conformation and tune the following self-assembly structure of CEs, and it has rarely been reported to da... |
39748762 | A New Type of Bioprosthetic Heart Valve: Synergistic Modification with Anticoagulant Polysaccharides and Anti-inflammatory Drugs. | Valvular heart disease (VHD) poses a significant threat to human health, and the transcatheter heart valve replacement (THVR) is the best treatment for severe VHD. Currently, the glutaraldehyde cross-linked commercial bioprosthetic heart valves (BHVs) remain the first choice for THVR. However, the cross-linking by glut... |
39748400 | Co-housing with Tibetan chickens improved the resistance of Arbor Acres chickens to Salmonella enterica serovar Enteritidis infection by altering their gut microbiota composition. | <h4>Background</h4>Salmonella enterica serovar Enteritidis (S. Enteritidis) is a global foodborne pathogen that poses a significant threat to human health, with poultry being the primary reservoir host. Therefore, addressing S. Enteritidis infections in poultry is crucial to protect human health and the poultry industr... |
39747850 | Radiopharmaceuticals and their applications in medicine. | Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for the diagnosis and treatment of multiple diseases. Radiopharmaceutical therapy, which directly causes systematic and irreparable damage to targeted cells, has attracted increasing attention in the treatment of refractory diseases th... |
39745947 | Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein. | The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the <i>Plasmodium falciparum</i> circumsporozoite protein (PfCSP). Here, using an antigen-agnostic strategy to investigate human antibody responses to whole sporozoites, we id... |
39714804 | Antimicrobial Potential of a Formazanate-Based Mercury(II) Complex: In Vitro- and In Silico-Based Insights. | Herein, we present a distorted square pyramidal mercury complex, [Hg<sup>II</sup>(L)Cl] (1), based on a quinoline-substituted formazan ligand LH[3-Cyano-1,5-(quinolin-8-yl)formazan], which was evaluated for its anti-bacterial activity in vitro. Complex 1 was prepared by refluxing 3-Cyano-1,5-(quinolin-8-yl)formazan lig... |
39714453 | Liquid Crystalline Nanorods by Synchronized Polymerization, Self-Assembly and Oriented Attachment for Utilization in Magnetically Responsive Displays. | The creation of anisotropic nanoparticles (NPs) by polymerization and/or self-assembly (SA) has significantly promoted the applications of polymer nanomaterials in many fields. However, polymer nanorods are not easily accessible via conventional polymerization or SA. Here we report a one-step route to synthesize single... |
39714439 | Precise Supramolecular Nanoarchitectonics for Simultaneous Enhanced Photoluminescence and Photocatalysis in a Co-Assembly by a Biomimetic Isolation-Conduction Strategy. | Limited by the two mutually exclusive physicochemical processes of separation and recombination of photogenerated carriers, achieving photoluminescence and photocatalysis simultaneously is extremely challenging but essential for ever-growing complex issues and specialized scenarios. Here we proposed a biomimetic isolat... |
40851676 | Elucidating Fluorine Steering Effects in Diels-Alder Reactions Interfaced with Charge-Enhanced Reactivity. | Fluorinated molecules are core to contemporary drug discovery programs and critical for advancing innovation in numerous fields. In merging these important chemical themes, fluorinated Diels-Alder cycloaddition products are a particularly attractive subset of compounds with significant utility. Herein, an in-depth comp... |
40777811 | Applications of magnetic nanoparticles for boundarics in biomedicine. | Accurate mapping of boundarics in biomedicine is crucial for improving early diagnosis, crafting individualized medical regimens, and evaluating therapeutic efficacy. Magnetic nanomaterials have attracted considerable attention in the diagnosis and treatment of disease lesions, due to their unique physicochemical prope... |
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