id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
40777770 | Programmable DNA-based biomaterials for bone tissue engineering. | Bone defects are a common pathology in bone tissue diseases, and existing therapeutic interventions have significant limitations, highlighting the need for innovative strategies and advanced biomaterials. DNA, traditionally recognized as a prominent genetic material, also possesses exceptional properties as a biologica... |
40190624 | Novel three-dimensional analysis method for accurate evaluation of cutaneous small sensory nerve fibers in mice. | Intraepidermal nerve fiber (IENF) density is commonly evaluated to diagnose peripheral neuropathy. However, conventional two-dimensional (2D) analysis using rodent models shows high interstudy variability. Three-dimensional (3D) IENF analysis has been proposed for human skin biopsies because the spatial location of eac... |
39926633 | Efficient anticancer drug delivery using nano-colloids self-assembled with an unconventional amphiphile bearing pumpkin-shaped host molecule. | A new type of amphiphiles bearing macrocycle such as cucurbit[7]uril (CB[7]) spontaneously forms a nanomaterial in water, specifically vesicles (<i>t</i>ACB[7] vesicles) with a positive surface charge, verified through various analytical techniques including TIRF, DLS and TEM. Functional validation not only reveals the... |
39917083 | One Step Further: A Flexible Metal-Organic Framework that Functions as a Dual-Purpose Water Vapor Sorbent. | We report a water induced phase transformation in a flexible MOF, [Zn<sub>3</sub>(OH)<sub>2</sub>(btca)<sub>2</sub>] (Hbtca = 1H-benzotriazole-5-carboxylic acid), that exhibits a two-step water vapor sorption isotherm associated with water-induced phase transformations. Variable temperature X-ray diffraction studies re... |
39917081 | Polymorphism of [Cu<sub>15</sub>(PhCH<sub>2</sub>CH<sub>2</sub>S)<sub>13</sub>(PPh<sub>3</sub>)<sub>6</sub>][BF<sub>4</sub>]<sub>2</sub> and Double-Helical Assembly of [Cu<sub>18</sub>H(PhCH<sub>2</sub>CH<sub>2</sub>S)<sub>14</sub>(PPh<sub>3</sub>)<sub>6</sub>Cl<sub>3</sub>]: Origin of Two Chiral Nanoclusters with Trip... | Here, we report the solvent-induced polymorphism in [Cu<sub>15</sub>(PET)<sub>13</sub>(TPP)<sub>6</sub>][BF<sub>4</sub>]<sub>2</sub>(Cu<sub>15</sub>) (TPP = triphenylphosphine, PET = 2-phenylethanthiol), and double-helical assembly of the [Cu<sub>18</sub>H(PET)<sub>14</sub>(TPP)<sub>6</sub>Cl<sub>3</sub>] (Cu<sub>18</s... |
39898043 | Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein. | G protein-coupled receptors (GPCRs) and G proteins transmit signals from hormones and neurotransmitters across cell membranes, initiating downstream signaling and modulating cellular behavior. Using advanced computer modeling and simulation, we identified atomistic-level structural, dynamic, and energetic mechanisms of... |
39898034 | Snapshots of <i>Pseudomonas aeruginosa</i> SOS response reveal structural requisites for LexA autoproteolysis. | Antimicrobial resistance poses a severe threat to human health and <i>Pseudomonas aeruginosa</i> stands out among the pathogens responsible for this emergency. The SOS response to DNA damage is crucial in bacterial evolution, influencing resistance development and adaptability in challenging environments, especially un... |
39897552 | Tumor microenvironment targeted nano-drug delivery systems for multidrug resistant tumor therapy. | In recent years, nano-drug delivery systems (Nano-DDS) that target the tumor microenvironment (TME) to overcome multidrug resistance (MDR) have become a research hotspot in the field of cancer therapy. By precisely targeting the TME and regulating its unique pathological features, such as hypoxia, weakly acidic pH, and... |
39897548 | Stimulus-responsive smart bioactive glass composites for repair of complex tissue defects. | Smart biomaterials with active environmental responsiveness have attracted widespread attention in recent years. Previous studies on bioactive glass (BG) have mainly focused on the property of bioactivity, while little attention has been paid to the property of smart response of BG. Herein, we propose the concept of Sm... |
39897543 | Metabolism of hepatic stellate cells in chronic liver diseases: emerging molecular and therapeutic interventions. | Chronic liver diseases, primarily metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic and metabolic dysfunction-associated alcoholic liver disease (MetALD), and viral hepatitis, can lead to liver fibrosis, cirrhosis, and cancer. Hepatic stellate cell (HSC) activation plays a central role in the ... |
39895690 | Tumor-specific cytosol-penetrating antibodies for antigen- and TME-dependent intracellular cargo delivery. | Although a considerable number of disease-related biomolecular interactions occur in the cytosol, therapeutic and diagnostic application of target-specific binding proteins is largely confined to surface-exposed or extracellular targets. Therefore, protein-cargo delivery approaches, including cell-penetrating peptides ... |
39852814 | Anti-Idiotypic Antibody as a Booster Vaccine Against Respiratory Syncytial Virus. | <b>Background/Objectives:</b> The respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in children and adults. With nearly everyone infected by the age of five, there is an opportunity to develop booster vaccines that enhance B-cell immunity, promoting potent and broadly neutralizing... |
39852065 | Polysaccharide Hydrogel-Assisted Biosensing Platforms for Point-of-Care Use. | Point-of-care (POC) use is one of the essential goals of biosensing platforms. Because the increasing demand for testing cannot be met by a centralized laboratory-based strategy, rapid and frequent testing at the right time and place will be key to increasing health and safety. To date, however, there are still difficu... |
39852003 | Toward Customizable Smart Gels: A Comprehensive Review of Innovative Printing Techniques and Applications. | New production technologies have transformed modern engineering fields, including electronics, mechanics, robotics, and biomedicine. These advancements have led to the creation of smart materials such as alloys, polymers, and gels that respond to various stimuli. This review focuses on smart materials (SMs), including ... |
39852001 | Fundamentals and Advances in Stimuli-Responsive Hydrogels and Their Applications: A Review. | This review summarizes the fundamental concepts, recent advancements, and emerging trends in the field of stimuli-responsive hydrogels. While numerous reviews exist on this topic, the field continues to evolve dynamically, and certain research directions are often overlooked. To address this, we classify stimuli-respon... |
39852000 | Rapid Multi-Well Evaluation of Assorted Materials for Hydrogel-Assisted Giant Unilamellar Vesicle Production: Empowering Bottom-Up Synthetic Biology. | Giant unilamellar vesicles (GUVs) are versatile cell models in biomedical and environmental research. Of the various GUV production methods, hydrogel-assisted GUV production is most easily implemented in a typical biological laboratory. To date, agarose, polyvinyl alcohol, cross-linked dextran-PEG, polyacrylamide, and ... |
39850052 | Elucidating the degradation mechanism of beef myofibrillar proteins under hydroxyl radical oxidation through the lens of cysteine oxidation modifications. | The study aimed to assess the oxidative modification behavior of bovine myofibrillar proteins (MPs) cysteines (Cys) by hydroxyl radical (·OH) through the construction of an in vitr Fenton reaction system. The ·OH generated by the Fenton reaction induced large-scale oxidative modification of Cys, and redox proteomics id... |
39850023 | Multivalent ionizable lipid-polypeptides for tumor-confined mRNA transfection. | mRNA therapeutics is revolutionizing the treatment concepts toward many diseases including cancer. The potential of mRNA is, however, frequently limited by modest control over site of transfection. Here, we have explored a library of multivalent ionizable lipid-polypeptides (MILP) to achieve robust mRNA complexation an... |
39846552 | Current Approaches for Genetic Manipulation of <i>Streptomyces</i> spp.-Key Bacteria for Biotechnology and Environment. | Organisms from the genus <i>Streptomyces</i> feature actinobacteria with complex developmental cycles and a great ability to produce a variety of natural products. These soil bacteria produce more than 2/3 of antibiotics used in medicine, and a large variety of bioactive compounds for industrial, medical and agricultur... |
39843111 | Highly stretchable, conductive, and self-adhesive starch-based hydrogel for high-performance flexible electronic devices. | To achieve the green and sustainable development of environment, biocompatible hydrogels with exceptional ionic conductivity and flexibility are highly desired for intelligent and wearable sensors. However, it remains a great challenge to obtain biopolymer hydrogel-based sensors with high transparency, excellent mechan... |
39831293 | Thermally and Base-Triggered "Debond-on-Demand" Chain-Extended Polyurethane Adhesives. | A series of novel chain-extended polyurethanes (CEPUs) featuring degradable sulfonyl ethyl urethane chain-extenders that permit degradation under base-triggered conditions to afford "debond-on-demand" elastomeric adhesives are reported. Exposure of the CEPUs to <i>tetra</i>-butylammonium fluoride (TBAF) triggered the d... |
39829584 | Supramolecular Ni(II)-Selective Gel Assembly toward Construction of a Schottky Barrier Diode. | A mechanically stable and thermo-irreversible supramolecular Ni(II)-selective gel (<b>MG</b>) has been developed by utilizing the N,O-donor Schiff base (E)-1-((4-(diethylamino)phenylimino)-methyl)naphthalen-2-ol (<b>HL</b>) gelator and Et<sub>3</sub>N in binary THF:CH<sub>3</sub>OH (1:1) solutions at room temperature (... |
39829511 | Silica Nanoparticles Modified by Biphenyl Groups for Crack-Free Coating on Synthetic Paper. | Water-based acrylic emulsions are a crucial component of water-based ink. Preventing visible cracks in emulsion coating during drying is a great challenge due to the high polarity and high surface tension of water. Herein, we propose that the cracking resistance of the coating can be enhanced through the incorporation ... |
39829502 | Steric and Electronic Effects of Zirconocenealkyl-Borate Ion Pairs on Catalyst Activation: A Theoretical Study. | The effectiveness of metallocene catalysts in the cationic ring-opening polymerization (cationic ROP) of ε-caprolactone (CL) is influenced by the choice of metallocene/borate systems, particularly their bulkiness. Recent research examines this effect on the initiation and propagation stages of cationic ROP. We conducte... |
39822742 | Integrated approach with UHPLC-Q-Exactive-tandem mass spectrometry, network analysis, and molecular docking to determine potential active compounds and mechanisms of Rhizoma Musae decoction in osteoarthritis treatment. | <h4>Objective</h4>This study aimed to identify the potential active compounds in Rhizoma Musae decoction and understand their mechanisms of action in osteoarthritis treatment.<h4>Methods</h4>UHPLC-Q-Exactive-MS/MS technology was used for an in-depth analysis of the chemical compounds present in Rhizoma Musae decoction.... |
39816695 | Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing. | <i>Rationale:</i> Next-generation wound dressings with multiple biological functions hold promise for addressing the complications and pain associated with burn wounds. <i>Methods:</i> A hydrogel wound dressing loaded with a pain-relieving drug was developed for treating infected burn wounds. Polyvinyl alcohol chemical... |
39816689 | Ultrasound-activated erythrocyte membrane-camouflaged Pt (II) layered double hydroxide enhances PD-1 inhibitor efficacy in triple-negative breast cancer through cGAS-STING pathway-mediated immunogenic cell death. | <b>Rationale:</b> Immunogenic cell death (ICD) offers a promising avenue for the treatment of triple-negative breast cancer (TNBC). However, optimizing immune responses remains a formidable challenge. This study presents the design of RBCm@Pt-CoNi layered double hydroxide (RmPLH), an innovative sonosensitizer for sonod... |
39816684 | Macrophage-based pathogenesis and theranostics of vulnerable plaques. | Vulnerable plaques, which are high-risk features of atherosclerosis, constitute critical elements in the disease's progression due to their formation and rupture. Macrophages and macrophage-derived foam cells are pivotal in inducing vulnerability within atherosclerotic plaques. Thus, understanding macrophage contributi... |
39816496 | Recent developments in antimicrobial small molecule quaternary phosphonium compounds (QPCs) - synthesis and biological insights. | The development and characterization of quaternary phosphonium compounds (QPCs) have long benefitted from their incorporation into a cornerstone reaction in organic synthesis - the Wittig reaction. These structures have, more recently, been developed into a wide variety of novel applications, ranging from phase transfe... |
39796389 | Construction of Pickering Double Emulsions Based on Xanthan Gum/Lysozyme Nanoparticles: Structure, Stability, and Co-Encapsulation of Epigallocatechin Gallate and β-Carotene. | The low stability of water-in-oil-in-water (W<sub>1</sub>/O/W<sub>2</sub>) double emulsions greatly limits their applications. Therefore, in this study, W<sub>1</sub>/O/W<sub>2</sub> Pickering double emulsions (PDEs) were prepared by a two-step emulsification method using polyglycerol polyricinoleate (PGPR) and xanthan... |
39796387 | Effect of Geographic Regions on the Flavor Quality and Non-Volatile Compounds of Chinese Matcha. | Matcha is a very popular tea food around the world, being widely used in the food, beverage, health food, and cosmetic industries, among others. At present, matcha shade covering methods, matcha superfine powder processing technology, and digital evaluations of matcha flavor quality are receiving research attention. Ho... |
39796193 | Antimicrobial Activity of <i>Bacillus</i> Cyclic Lipopeptides and Their Role in the Host Adaptive Response to Changes in Environmental Conditions. | <i>Bacillus</i> cyclic lipopeptides (CLP), part of the three main families-surfactins, iturins, and fengycins-are secondary metabolites with a unique chemical structure that includes both peptide and lipid components. Being amphiphilic compounds, CLPs exhibit antimicrobial activity in vitro, damaging the membranes of m... |
39796191 | GAPDH Gene Family in <i>Populus deltoides</i>: Genome-Wide Identification, Structural Analysis, and Expression Analysis Under Drought Stress. | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme widely involved in glycolysis in animal cells and in non-metabolic processes, including apoptosis and the regulation of gene expression. GAPDH is a ubiquitous protein that plays a pivotal role in plant metabolism and handling of stress responses. However, it... |
39795511 | Leveraging Microneedles for Raised Scar Management. | Disruption of the molecular pathways during physiological wound healing can lead to raised scar formation, characterized by rigid, thick scar tissue with associated symptoms of pain and pruritus. A key mechanical factor in raised scar development is excessive tension at the wound site. Recently, microneedles (MNs) have... |
39795373 | Functional Analysis of Durum Wheat GASA1 Protein as a Biotechnological Alternative Against Plant Fungal Pathogens and a Positive Regulator of Biotic Stress Defense. | Plants are frequently challenged by a variety of microorganisms. To protect themselves against harmful invaders, they have evolved highly effective defense mechanisms, including the synthesis of numerous types of antimicrobial peptides (AMPs). Snakins are such compounds, encoded by the <i>GASA</i> (Gibberellic Acid-Sti... |
39795208 | A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples. | Oseltamivir is a drug that has been widely used to prevent and treat influenza A and B. In this work, an ultrasensitive, simple, and novel electrochemiluminescence (ECL) sensor combined with molecularly imprinted polymers (MIP-ECL) based on a graphene-like two-dimensional material, Mxene quantum dots (MQDs) was constru... |
39795201 | Mercury Monohalides as Ligands in Transition Metal Complexes. | The main categories of transition metal-mercury heterometallic compounds are briefly summarized. The attention is focused on complexes and clusters where the {Hg-Y} fragment, where Y represents a halide atom, interacts with transition metals. Most of the structurally characterized derivatives are organometallic compoun... |
39791823 | Electrocatalytic and Photocatalytic N<sub>2</sub> Fixation Using Carbon Catalysts. | Carbon catalysts have shown promise as an alternative to the currently available energy-intensive approaches for nitrogen fixation (NF) to urea, NH<sub>3</sub>, or related nitrogenous compounds. The primary challenges for NF are the natural inertia of nitrogenous molecules and the competitive hydrogen evolution reactio... |
39791822 | Inverted Pyramid Nanostructures Coupled with a Sandwich Immunoassay for SERS Biomarker Detection. | Cancer diagnostics often faces challenges, such as invasiveness, high costs, and limited sensitivity for early detection, emphasizing the need for improved approaches. We present a surface-enhanced Raman scattering (SERS)-based platform leveraging inverted pyramid SU-8 nanostructured substrates fabricated via nanoimpri... |
39791817 | Tin(IV)Porphyrin-Based Porous Coordination Polymers as Efficient Visible Light Photocatalyst for Wastewater Remediation. | Two porphyrin-based polymeric frameworks, SnP-BTC and SnP-BTB, as visible light photocatalysts for wastewater remediation were prepared by the solvothermal reaction of <i>trans</i>-dihydroxo-[5,15,10,20-tetrakis(phenyl)porphyrinato]tin(IV) (SnP) with 1,3,5-benzenetricarboxylic acid (H<sub>3</sub>BTC) and 1,3,5-tris(4-c... |
39791816 | Preparation of Zwitterionic Sulfobetaines and Study of Their Thermal Properties and Nanostructured Self-Assembling Features. | Zwitterionic polymers have garnered significant attention for their distinctive properties, such as biocompatibility, antifouling capabilities, and resistance to protein adsorption, making them promising candidates for a wide range of applications, including drug delivery, oil production inhibitors, and water purificat... |
39791739 | In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead? | Haematological malignancies comprise a diverse group of life-threatening systemic diseases, including leukaemia, lymphoma, and multiple myeloma. Currently available therapies, including chemotherapy, immunotherapy, and CAR-T cells, are often associated with important side effects and with the development of drug resist... |
39778364 | Identification of quantitative trait loci and candidate genes associated with growth curve parameters in chinese wenshang barred chickens. | The growth curve is a vital instrument for assessing and forecasting weight and developmental shifts in livestock and poultry, which reflects the changes of bodyweight traits with time and plays a key role in guiding breeding and production approaches. This study performed a genome-wide association study (GWAS) for gro... |
39760110 | Nonviral targeted mRNA delivery: principles, progresses, and challenges. | Messenger RNA (mRNA) therapeutics have garnered considerable attention due to their remarkable efficacy in the treatment of various diseases. The COVID-19 mRNA vaccine and RSV mRNA vaccine have been approved on the market. Due to the inherent nuclease-instability and negative charge of mRNA, delivery systems are develo... |
39758922 | Laser-induced graphene functionalized cationic porphyrin: fabrication, characterization, and intra-supramolecular electron transfer process. | We report herein a facile synthesis, characterization, and the electron transfer reaction of a novel light-harvesting material composed of laser-induced graphene (LIG) functionalized with the photoactive 5,10,15,20-tetrakis(4-trimethylammoniophenyl)porphyrin tetra(<i>p</i>-toluenesulfonate) dye (TTMAPP). LIG was easily... |
39758913 | Bovine serum albumin under the influence of alkali metal halides. | The hydration shell of a protein is so important and an integral part of it, that protein's structure, stability and functionality cannot be conceived in its absence. This layer has unique properties not found in bulk water. However, ions, always present in the protein environment, disturb the hydration shell depending... |
39758901 | Stabilization of small organic molecules on V<sub>2</sub>C and V<sub>2</sub>CO<sub>2</sub> MXenes: first-principles insights into the performance of van der Waals functionals and the effect of oxygen vacancies. | The adsorption of small organic molecules on pristine V<sub>2</sub>C MXene and its derivatives is investigated by first-principles density functional theory calculations. By employing state-of-the-art van der Waals (vdW) density functionals, the binding affinity of studied molecules, <i>i.e.</i>, CH<sub>4</sub>, CO<sub... |
39758897 | Spiro thiochromene-oxindoles as novel anti-inflammatory agents: design, sustainable synthesis, <i>in vitro</i> and <i>in silico</i> evaluations. | A one-pot, acid-, base-, and metal-free, multicomponent strategy has been developed to synthesize spiro thiochromene-oxindole derivatives as potential anti-inflammatory agents. The synthesized compounds were screened <i>in vitro</i> for their anti-inflammatory activity by inhibiting heat-induced Bovine Serum Albumin (B... |
39758894 | Meniran (<i>Phyllanthus niruri</i> L.) embedded zeolitic imidazolate framework (ZIF-8) nanoparticle for cancer chemotherapy: supported molecular docking analysis. | Cancer is among the leading causes of mortality worldwide. Natural bioactive compounds like Meniran (<i>Phyllanthus niruri</i> L.) have been the focus of extensive research due to their potent anticancer properties. Nevertheless, drug delivery strategies may be necessary to encapsulate bioactive compounds, thereby redu... |
39755318 | Hydrolysis and transport characteristics of starch inclusion complexes with long-chain alkyl gallates: Controlled two-step release of gallic acid and retardation of starch digestion. | Corn starch inclusion complexes of alkyl gallates (typical phenololipid representatives), including stearyl gallate, dodecyl gallate, octyl gallate, and hexadecyl gallate, were synthesized by using a heat treatment method. Such inclusion complexes exhibited significantly improved two-step release properties for gallic ... |
39755071 | One-step biomineralization to synthesize reusable CRL@ZnCo-MOF for boosting lipase stability and sustainable dibutyl phthalate removal. | Adsorption and biodegradation are two important means to remove the pollutants from the environment, but how to combine them and improve the catalytic performance and stability of free enzyme are facing great challenges. Herein, lipase from Candida rugosa (CRL) was immobilized into bimetallic ZnCo-MOF by biomineralizat... |
39753134 | Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator. | Chemical inducers of proximity (CIPs) are molecules that recruit one protein to another and introduce new functionalities toward modulating protein states and activities. While CIP-mediated recruitment of E3 ligases is widely exploited for the development of degraders, other therapeutic modalities remain underexplored.... |
39753132 | Molecular basis of proton sensing by G protein-coupled receptors. | Three proton-sensing G protein-coupled receptors (GPCRs)-GPR4, GPR65, and GPR68-respond to extracellular pH to regulate diverse physiology. How protons activate these receptors is poorly understood. We determined cryogenic-electron microscopy (cryo-EM) structures of each receptor to understand the spatial arrangement o... |
39752250 | Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth. | Tumor-draining lymph node dendritic cells (DCs) are poor stimulators of tumor antigen-specific CD4 T cells; however, the mechanism behind this defect is unclear. We now show that, in tumor-draining lymph node DCs, a large proportion of major histocompatibility complex class II (MHC-II) molecules retains the class II-as... |
39748152 | Nanobased Natural Polymers as a Carrier System for Glyphosate: An Interesting Approach Aimed at Sustainable Agriculture. | Polymer-based herbicide nanocarriers have shown potential for increasing the herbicide efficacy and environmental safety. This study aimed to develop, characterize, and evaluate toxicity to target and nontarget organisms of natural-based polymeric nanosystems for glyphosate. Polymers such as chitosan (CS), zein (ZN), a... |
39748139 | Controlled Synthesis of Perovskite Nanocrystals at Room Temperature by Liquid Crystalline Templates. | Perovskite nanocrystals (PNCs) are promising active materials because of their outstanding optoelectronic properties, which are finely tunable via size and shape. However, previous synthetic methods such as hot-injection and ligand-assisted reprecipitation require a high synthesis temperature or provide limited access ... |
39748142 | Rare Earth Complex-Based Functional Materials: From Molecular Design and Performance Regulation to Unique Applications. | ConspectusRare earth (RE) elements, due to their unique electronic structures, exhibit excellent optical, electrical, and magnetic properties and thus have found widespread applications in the fields of electronics, optics, and biomedicine. A significant advancement in the use of RE elements is the formation of RE comp... |
39748105 | MIL-53(Al)-derived bimetallic Pd-Co catalysts for the selective hydrogenation of 1,3-butadiene at low temperature. | Selective hydrogenation of 1,3-butadiene is a crucial industrial process for the removing of 1,3-butadiene, a byproduct of butene production. Developing catalysts with high catalytic performance for the hydrogenation of 1,3-butadiene at low temperatures has become a research hotspot. In this study, bimetallic Pd-Co cat... |
39748078 | Molecular dynamics simulations reveal efficient heavy metal ion removal by two-dimensional Cu-THQ metal-organic framework membrane. | Two-dimensional (2D) metal-organic frameworks (MOFs) have been extensively utilized across various research areas. However, the application of 2D MOF-based membranes for the removal of heavy metal ions remains largely unexplored, despite their potential as suitable candidates due to their inherent porosity. In this stu... |
39748046 | Development and characterization of a surfactant responsive to redox conditions for gas recovery in foam drainage. | To address the challenge of reusing foaming agents in foam drainage gas production processes, we developed a redox-responsive surfactant with a straightforward preparation method based on molecular electrostatic interaction assembly. The redox response mechanism of the surfactant was investigated through surface tensio... |
39747973 | A novel electrochemical sensor for the determination of cadmium ions based on nitrogen-enriched carbon modified electrode. | In the present work, nitrogen-doped carbon was synthesized starting from a chitosan/urea mixture and immobilized at the surface of a bare glassy carbon electrode to detect Cd(II) ions using differential pulse-anodic stripping voltammetry method (DP-ASV). The synthesized nitrogen-doped carbon showed a significant potent... |
39747940 | Effect of stearic acid and sodium stearate on hydrophobicity of nano calcium carbonate and mechanism of water vapor adsorption. | It is essential to understand the modification mechanism of hydrophobicity nano-CaCO<sub>3</sub> to their potential application in different fields of chemistry. However, the water absorption of hydrophobicity nano-CaCO<sub>3</sub> is seldom studied. In this study, Raman, BET and TGA experiments were performed on nano-... |
39747904 | Unravelling nonclassical beam damage mechanisms in metal-organic frameworks by low-dose electron microscopy. | Recent advances in direct electron detectors and low-dose imaging techniques have opened up captivating possibilities for real-space visualization of radiation-induced structural dynamics. This has significantly contributed to our understanding of electron-beam radiation damage in materials, serving as the foundation f... |
39747898 | Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance. | Yes-associated protein (YAP) activation confers resistance to chemotherapy and targeted therapy. Methionine participates in cellular processes by converting to methyl donor for the methylation of DNA, RNA and protein. However, it remains unclear whether methionine affects drug resistance by influencing YAP activity. In... |
39747902 | Phthalocyanine aggregates as semiconductor-like photocatalysts for hypoxic-tumor photodynamic immunotherapy. | Photodynamic immunotherapy (PIT) has emerged as a promising approach for efficient eradication of primary tumors and inhibition of tumor metastasis. However, most of photosensitizers (PSs) for PIT exhibit notable oxygen dependence. Herein, a concept emphasizing on transition from molecular PSs into semiconductor-like p... |
39747901 | L-Aspartic acid-functionalized magnetic nanoparticles: as a new magnetically reusable bifunctional acid-base catalysts for the synthesis of benzo[b]pyran and pyrano[3,2-c] chromene derivatives. | "Green chemistry" describes the development of new technologies that reduce or eliminate the need for hazardous compounds or the production of them. In order to accomplish this goal, we have developed a new magnetic recyclable biocatalyst in this study by successfully applying aspartic acid to magnetic nanoparticles. A... |
39747896 | Programming scheduled self-assembly of circadian materials. | Active biological molecules present a powerful, yet largely untapped, opportunity to impart autonomous regulation of materials. Because these systems can function robustly to regulate when and where chemical reactions occur, they have the ability to bring complex, life-like behavior to synthetic materials. Here, we ach... |
39747880 | Artificial molecular communication network based on DNA nanostructures recognition. | Artificial simulated communication networks inspired by molecular communication in organisms use biological and chemical molecules as information carriers to realize information transmission. However, the design of programmable, multiplexed and general simulation models remains challenging. Here, we develop a DNA nanos... |
39747875 | Rational engineering of minimally immunogenic nucleases for gene therapy. | Genome editing using CRISPR-Cas systems is a promising avenue for the treatment of genetic diseases. However, cellular and humoral immunogenicity of genome editing tools, which originate from bacteria, complicates their clinical use. Here we report reduced immunogenicity (Red)(i)-variants of two clinically relevant nuc... |
39747870 | Molecular insights into a distinct class of terpenoid cyclases. | Terpenoid cyclases (TCs) account for the synthesis of the most widespread and diverse natural compounds. A sesquiterpene cyclase termed BcABA3 from an abscisic acid-producing fungus Botrytis cinerea that yields (2Z,4E)-α-ionylideneethane but lacks signature feature of canonical TCs represents a distinct type of TCs. He... |
39747847 | Efficient direct formic acid electrocatalysis enabled by rare earth-doped platinum-tellurium heterostructures. | The lack of high-efficiency platinum (Pt)-based nanomaterials remains a formidable and exigent challenge in achieving high formic acid oxidation reaction (FAOR) and membrane electrode assembly (MEA) catalysis for direct formic acid fuel cell (DFAFC) technology. Herein, we report 16 Pt-based heterophase nanotrepang with... |
39747845 | Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy. | The discovery of tertiary lymphoid structures (TLS) within tumor tissues provides a promising avenue to promote the efficacy of cancer immunotherapy. Yet, the lack of effective strategies to induce TLS formation poses a substantial obstacle. Thus, the exploration of potential inducers for TLS formation is of great inte... |
39747830 | Endowing single-crystal polymers with circularly polarized luminescence. | The preparation of single-crystal polymers with circularly polarized luminesce (CPL) remains a challenging task in chemistry and materials science. Herein, we present the single-crystal-to-single-crystal topochemical photopolymerization of a chiral organic salt to achieve this goal. The in-situ reaction of 1,4-bis((E)-... |
39747832 | Precise Control of Regioselective <i>N</i><sup>1</sup> and <i>N</i><sup>2</sup>-Alkylation of Benzotriazoles with α-Diazoacetates by Metalloporphyrin. | Regioselective <i>N</i>-alkylation of benzotriazole is highly important to prepare biological materials. Herein, a series of A<sub>2</sub>B<sub>2</sub>-typed porphyrin and metalloporphyrin compounds were prepared. Catalytic results disclosed that Ir(III) pentafluorophenyl-substituted porphyrin promoted selective <i>N</... |
39747821 | An aperiodic chiral tiling by topological molecular self-assembly. | Studying the self-assembly of chiral molecules in two dimensions offers insights into the fundamentals of crystallization. Using scanning tunneling microscopy, we examine an uncommon aggregation of polyaromatic chiral molecules on a silver surface. Dense packing is achieved through a chiral triangular tiling of triads,... |
39747820 | Oriented wide-bandgap perovskites for monolithic silicon-based tandems with over 1000 hours operational stability. | The instability of hybrid wide-bandgap (WBG) perovskite materials (with bandgap larger than 1.68 eV) still stands out as a major constraint for the commercialization of perovskite/silicon tandem photovoltaics, yet its correlation with the facet properties of WBG perovskites has not been revealed. Herein, we combine exp... |
39747695 | Gut-liver translocation of pathogen Klebsiella pneumoniae promotes hepatocellular carcinoma in mice. | Hepatocellular carcinoma (HCC) is accompanied by an altered gut microbiota but whether the latter contributes to carcinogenesis is unclear. Here we show that faecal microbiota transplantation (FMT) using stool samples from patients with HCC spontaneously initiate liver inflammation, fibrosis and dysplasia in wild-type ... |
39747692 | Metagenomic immunoglobulin sequencing reveals IgA coating of microbial strains in the healthy human gut. | IgA, the primary human antibody secreted from the gut mucosa, shapes the intestinal microbiota. Methodological limitations have hindered defining which microbial strains are targeted by IgA and the implications of binding. Here we develop a technique, metagenomic immunoglobulin sequencing (MIg-seq), that provides strai... |
39747671 | Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery. | G protein-coupled receptors (GPCRs) are the largest human membrane protein family that transduce extracellular signals into cellular responses. They are major pharmacological targets, with approximately 26% of marketed drugs targeting GPCRs, primarily at their orthosteric binding site. Despite their prominence, predict... |
39747658 | TRIM32 regulates insulin sensitivity by controlling insulin receptor degradation in the liver. | Impaired insulin receptor signaling is strongly linked to obesity-related metabolic conditions like non-alcoholic fatty liver disease (NAFLD) and Type 2 diabetes (T2DM). However, the exact mechanisms behind impaired insulin receptor (INSR) signaling in obesity induced by a high-fat diet remain elusive. In this study, w... |
39747662 | HDAC6 deacetylates TRIM56 to negatively regulate cGAS-STING-mediated type I interferon responses. | Histone deacetylase HDAC6 has been implicated in regulating antiviral innate immunity. However, its precise function in response to DNA virus infection remains elusive. Herein, we find that HDAC6 deficiency promotes the activation of cGAS-STING signaling and type I interferon (IFN) production, both in vitro and in vivo... |
39747620 | Development of nanofiber facial mask inspired by the multi-function of dried ginger (Zingiberis Rhizoma) essential oil. | Plant extracts, especially herbal extracts, are in line with the cosmetics development trend of natural and safe in today's world. Dried ginger essential oil (DGEO) is a fragrant oily liquid extracted from the dried roots of Zingiber officinale Rosc. This research investigated DGEO could effectively inhibit Staphylococ... |
39747624 | Microfluidic 3D cell culture: potential application of collagen hydrogels with an optimal dose of bioactive glasses. | We engineered a microfluidic platform to study the effects of bioactive glass nanoparticles (BGNs) on cell viability under static culture. We incorporated different concentrations of BGNs (1%, 2%, and 3% w/v) in collagen hydrogel (with a concentration of 3.0 mg/mL). The microfluidic chip's dimensions were optimized thr... |
39747573 | NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats. | Arginine-rich dipeptide repeat proteins (R-DPRs) are highly toxic proteins found in patients with C9orf72-linked amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). R-DPRs can cause toxicity by disrupting the natural phase behavior of RNA-binding proteins (RBPs). Mitigating this abnormal phase behav... |
39747525 | MOFs-based adsorbents for the removal of tetracycline from water and food samples. | Tetracyclines (TCs) are widely employed for the prevention and treatment of diseases in animals besides being deployed to promote animal growth and weight gain. Such practices result in trace amounts of TCs occurrence in water and foodstuffs of animal origin, including eggs and milk, thus posing severe health risks to ... |
39747506 | Assessing the impact of community-based homestay experiences on tourist loyalty in sustainable rural tourism development. | In the context of community-based tourism, this study investigates the determinants of tourist loyalty to homestays, with a focus on sustainable rural tourism development in China. Using the stimulus-organism-response (SOR) framework, we propose a conceptual model to examine how connected experiences influence tourist ... |
39747465 | Network pharmacology and molecular docking to explore the potential mechanism of chlorogenic acid in septic acute liver injury and experimental validation of TLR4/NF-κB pathway in vivo. | The objective of this study was to investigate the biological activities and mechanisms of chlorogenic acid (CGA) in the treatment of septic acute liver injury (SALI) based on the network pharmacology, molecular docking, in vivo studies, and other techniques. Chlorogenic acid and potential related targets of septic acu... |
39747400 | Innovative cross-linked electrospun PVA/MOF nanocomposites for removal of cefixime antibiotic. | In this study, we synthesized two nanocomposites, cross-linked PVA/HKUST and PVA/ZIF-67, by integrating metal-organic frameworks (MOFs) into electrospun polyvinyl alcohol (PVA). Several characterization techniques including FTIR, XRD, ICP, SEM, TGA, UV-Vis, zeta potential, and N<sub>2</sub> adsorption-desorption were e... |
39747348 | In-vitro antifungal potential of myco versus bacteria synthesized ZnO NPs against chickpea and apricot pathogen. | Chickpea (Cicer arietinum) and Apricot (Prunus armeniaca) both are economically and nutritionally important, these both faces severe losses due to fungal Infections. For several fungal infections, traditional methods of management rely on chemical fungicideswhich have environmental and health risks. The in-vitro antifu... |
39747342 | Synthesis and characterization of allomelanin model from 1,8-dihydroxynaphthalene autooxidation. | In this work a novel method for synthesis of 1,8-dihydroxynaphthalene melanin was presented, as well as the physicochemical properties, molecular structure, and characteristics of the pigment. The proposed synthesis protocol is simple and cost-effective with no enzymes or catalysts needed. The final product is not adso... |
39747282 | Ascorbic acid-immobilized zinc selenide for electrochemical monitoring of hydrogen peroxide in liver cancer samples. | Liver cancer is globally the most frequent fatal malignancy, and its identification is critical for making clinical decisions about treatment options. Pathological diagnostics and contemporary imaging technologies provide insufficient information for tumor identification. Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>),... |
39747259 | Floatable artificial leaf to couple oxygen-tolerant CO<sub>2</sub> conversion with water purification. | To enable open environment application of artificial photosynthesis, the direct utilization of environmental CO<sub>2</sub> via an oxygen-tolerant reductive procedure is necessary. Herein, we introduce an in situ growth strategy for fabricating two-dimensional heterojunctions between indium porphyrin metal-organic fram... |
39747249 | General synthesis of neighboring dual-atomic sites with a specific pre-designed distance via an interfacial-fixing strategy. | A potential non-precious metal catalyst for oxygen reduction reaction should contain metal-N<sub>4</sub> moieties. However, most of the current strategies to regulate the distances between neighboring metal sites are not pre-designed but depend on the probability by tuning the metal loading or the support. Herein, we r... |
39747239 | Sulfur-locked multiple resonance emitters for high performance orange-red/deep-red OLEDs. | Multiple resonance thermally activated delayed fluorescence (MR-TADF) materials are preferred for their high efficiency and high colour purity in organic light-emitting diodes (OLEDs). However, the design strategies of MR-TADF emitters in the red region are very limited. Herein, we propose a concept for a paradigm shif... |
39747237 | 2.5-dimensional covalent organic frameworks. | Covalently bonded crystalline substances with micropores have broad applications. Covalent organic frameworks (COFs) are representative of such substances. They have so far been classified into two-dimensional (2D) and three-dimensional (3D) COFs. 2D-COFs have planar shapes useful for broad purposes, but obtaining good... |
39747218 | The hybrid lipoplex induces cytoskeletal rearrangement via autophagy/RhoA signaling pathway for enhanced anticancer gene therapy. | Delivering plasmid DNA (pDNA) to solid tumors remains a significant challenge due to the requirement for multiple transport steps and the need to promote delivery efficiency. Herein, we present a virus-mimicking hybrid lipoplex, composed of an arginine-rich cationic lipid, hyaluronic acid derivatives coated gold nanopa... |
39747211 | Computational and GC-MS screening of bioactive compounds from Thymus Vulgaris targeting mycolactone protein associated with Buruli ulcer. | Buruli ulcer (BU) a neglected disease induced by the bacterium Mycobacterium ulcerans, predominantly impacts tropical and subtropical areas with its pathophysiology ascribed to the Mycolactone protein. Current antibiotics frequently prove insufficient to manage advanced or chronic ulcers and the rise of drug resistance... |
39747194 | Interfacial coupling effects in two-dimensional ordered arrays for microwave attenuation. | With the development of nanotechnology, nano-functional units of different dimensions, morphologies, and sizes exhibit the potential for efficient microwave absorption (MA) performance. However, the multi-unit coupling enhancement mechanism triggered by the alignment and orientation of nano-functional units has been ne... |
39747180 | Deficiency in NPC2 results in disruption of mitochondria-late endosome/lysosomes contact sites and endo-lysosomal lipid dyshomeostasis. | Dysfunction of the endo-lysosomal intracellular Cholesterol transporter 2 protein (NPC2) leads to the onset of Niemann-Pick Disease Type C (NPC), a lysosomal storage disorder. Metabolic and homeostatic mechanisms are disrupted in lysosomal storage disorders (LSDs) hence we characterized a cellular model of NPC2 knock o... |
39747174 | Discovering natural products as potential inhibitors of SARS-CoV-2 spike proteins. | The ongoing global pandemic caused by the SARS-CoV-2 virus has demanded the urgent search for effective therapeutic interventions. In response, our research aimed at identifying natural products (NPs) with potential inhibitory effects on the entry of the SARS-CoV-2 spike (S) protein into host cells. Utilizing the Prote... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.