id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
41824429 | Phytochemical profiling of Vitex negundo seeds via UHPLC-QTOF-MS/MS analyses with antimicrobial evaluation and in silico targeting of DNA Gyrase B and Secreted Aspartic Proteinase 2 (SAP2). | The present study reports the metabolic profiling and antimicrobial evaluation of Vitex negundo seed extract. UHPLC-QTOF-MS/MS analysis identified seventeen bioactive phytoconstituents, correlated with the observed antimicrobial and antifungal activities. Among them, isoorientin (-7.3 kcal mol ⁻ ¹), quercetin (-7.8 kca... |
41824427 | Elucidating the mechanistic association of xylene inducing non-small cell lung cancer through network toxicology and molecular docking analysis. | Xylene is a common industrial solvent that includes three isomers: o-xylene, m-xylene, and p-xylene. Long-term exposure to low doses of xylene in the environment has been linked to a higher risk of lung cancer. However, the molecular mechanisms behind this link are still not fully understood. In this study, we used a c... |
41824400 | Investigation of Hyperfine Interactions in Molecular Spin Qubits Constructed from A Nitronyl-Nitroxide Ligand and Transition Metal Ions. | The qubit behavior of two <i>S</i> = 1/2 heterospin complexes with the general formula (Et<sub>3</sub>NH)[M(hfac)<sub>2</sub>L] has been investigated by pulse EPR methods (M = Zn (<b>1</b>) and Ni (<b>2</b>), hfac<sup><i>-</i></sup> is the coligand hexafluoroacetylacetonate and L<sup><i>-</i></sup> is the deprotonated ... |
41824372 | An Atomic-Level Bimetallic MOF Platform Overcoming the Stability-Performance Tradeoff for Laser Propulsion. | This work establishes a materials design paradigm that achieves simultaneous enhanced stability and performance for photon-based propulsion. We introduce an atomic-level bimetallic platform to overcome the inherent trade-off between high thrust efficiency and environmental stability, particularly against hydrolysis. Th... |
41824369 | Inorganic Cobalt Sandwich Complex [(η<sup>5</sup>-P<sub>5</sub>)Co(η<sup>3</sup>-P<sub>3</sub>)]<sup/>. | Sandwich compounds are foundational to organometallic chemistry, yet carbon-free analogs remain exceptionally rare. We report the all-phosphorus heteroleptic cobalt sandwich anion [(η<sup>5</sup>-P<sub>5</sub>)Co(η<sup>3</sup>-P<sub>3</sub>)]<sup>-</sup> (<b>4</b>), obtained via a stepwise P<sub>4</sub> activation/unma... |
41824278 | Effect of ligand alkyl chain length on lanthanide extraction using liposomes incorporating diglycolamic acid. | This study introduces an environmentally benign liposome-based extraction system that selectively separates and recovers lanthanides (Ln) without requiring an organic solvent. Recovery of Ln, particularly from high-level radioactive liquid waste streams, is critical for resource utilization and reducing long-term radio... |
41824223 | Structural pharmacology of Chinese medicine: technological breakthroughs in decoding multi-target synergy and precision mechanisms. | Traditional Chinese Medicine (TCM) offers valuable therapeutic strategies for chronic and infectious diseases, yet the inherent complexity of its multi-component, multi-target formulations and synergistic effects presents substantial challenges to pharmacological mechanistic understanding. Structural pharmacology of Ch... |
41824096 | Computational chemistry methods based on MNDO and tools for improving their accuracy. | <h4>Context</h4>Semiempirical computational methods based on the MNDO approximation have a long history. Since its release in 1977, the original MNDO method has evolved steadily, passing through several forms (AM1, PM3, etc.) up to the present. Each new form represented an improvement, and it is anticipated that the ev... |
41823718 | Fractures at virtually all sites are associated with adverse outcomes: an observational study. | The FRAX model defines fractures occurring at the hip, vertebrae, humerus, and forearm as major osteoporotic fractures (MOF), leading to the misconception that fractures at other sites (NonMOF) are unimportant. We aimed to compare MOF and NonMOF to 1) assess their contribution to subsequent fracture and mortality risks... |
41823563 | Engineering Full-Spectrum (UV-Vis-NIR) Photocatalytic Antibiotic Oxidation in Metal-Organic Frameworks via Dual-Ligand-to-Metal Charge Transfer. | Tailoring the electronic structure of metal-organic frameworks (MOFs) has been recognized as a viable approach to promote the photocatalytic activity toward antibiotic oxidation. However, conventional single-ligand MOFs are plagued by notable drawbacks, such as inefficient spatial separation of photogenerated electron-... |
41823547 | Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review). | Enolase 1 (ENO1) plays a pivotal role in tumor development, recognized as a multifunctional oncogene across diverse cancers. Initially known for its central role in glycolysis, where it catalyzes the conversion of 2‑phosphoglycerate to phosphoenolpyruvate, the influence of ENO1 extends far beyond. Recent studies have u... |
41823531 | Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review). | Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, are characterized by progressive loss of neurons. Although the precise pathogenesis of such diseases is complex and multifactorial, several molecular pathways have been implicated, including the aggregation... |
41823428 | Driving forces of the humification process in composting: from a microbial perspective. | In composting, humification is critical for final compost quality and effectiveness and involves small molecules polymerizing into humic substances (HS). Microbial metabolism, as the core process of composting, drives this transformation. However, the full relationship between microbial metabolic processes and humifica... |
41823151 | AI-Integrated Conformal Cellulose Nanofiber-Reinforced Hydrogel Patch for Dual-Ratiometric Fluorescence Monitoring of Pyrimethanil Residues. | Real-time and on-site monitoring of pesticide residues remains challenging due to the lack of plant-interfaced, actively enriching, and nondestructive analytical devices. Herein, we present an intelligent, plant-conformal cellulose nanofiber (CNF)-reinforced hydrogel sensor with dual-emission fluorescence for in situ q... |
41823134 | Synthesis of <i>N</i>-Unsubstituted 1-Aminoisoquinolines via Rh(III)-Catalyzed C-H Activation/Annulation of Benzamidine Hydrochloride with Diazo Compounds. | An efficient protocol for the synthesis of <i>N</i>-unsubstituted 1-aminoisoquinolines via Rh(III)-catalyzed C-H cascade annulation using benzamidine hydrochloride and α-diazocarbonyl compounds has been presented. A series of <i>N</i>-unsubstituted 1-aminoisoquinolines can be obtained in moderate-to-good yields from th... |
41823083 | Recent Advances in Sustainable Single-Atom Catalysts from Biomass and Solid Waste: Design, Synthesis and Applications. | Single-atom catalysts (SACs), featuring isolated metal atoms anchored on engineered supports, have emerged as a transformative class of catalytic materials. Their atomically dispersed active sites enable nearly 100% metal utilization, unique electronic structures, and highly tunable coordination environments, which res... |
41823018 | An Engineered SIM@ZIF-8 Hydrogel Synergistically Enhances Vascularized Bone Regeneration in an Osteoporotic Environment. | To address the coupled impairment of osteogenesis and angiogenesis in osteoporosis, we developed a synergistic two-factor delivery strategy based on photo-cross-linked nanocomposite hydrogels (nSZCSG). This system innovatively integrates simvastatin (SIM) loaded zeolite imidazolate skeleton-8 (ZIF-8) nanoparticles into... |
41823016 | Decoding the mechanisms of amyloid-β in synaptic toxicity. | Amyloid-β (Aβ) aggregation is considered a central hallmark in the pathophysiology of Alzheimer's disease (AD). Aβ protein aggregates disrupt synaptic architecture, calcium homeostasis, and mitochondrial function, leading to excitotoxicity and synaptic plasticity deficits. Animal models and human studies reveal that Aβ... |
41821504 | Dual-Functional Photonic Crystal Hydrogel: Drug Release Monitoring and Immunomodulation for Chronic Infected Wounds. | Chronic bacterial-infected wounds are difficult to treat due to persistent inflammation, biofilm formation, and antibiotic resistance. Conventional therapeutic approaches, such as systemic or topical antibiotics, are limited by the inability to dynamically monitor drug release at the wound site. To address this issue, ... |
41821489 | Highly Uniform Pyrene-Based Host-Guest-Doped Organic Thin Films with Ultralow ASE Threshold and High Stability. | Organic semiconductor thin-film lasers hold broad application prospects. High-quality organic films can effectively reduce optical losses in the gain medium, thereby enhancing the operational efficiency and stability of the devices. However, due to the occurrence of postgrowth evolution, organic thin films may undergo ... |
41820749 | Multifunctional synergistic action of metal-organic framework composites enhance the electrochemical detection sensitivity of dopamine. | Metal-organic frameworks (MOFs) have shown major promise for electrochemical dopamine (DA) sensing owing to their high surface area, tunable pores, and abundant active sites. In this work, iron-tetra(4-carboxyphenyl)porphyrin-coordinated assembly metal-organic framework (Fe-TCPP MOF material) capable of effectively cat... |
41820410 | Optical, luminescence and magnetic properties of braunite‒rhodonite nanocomposites synthesized by green aqueous sol‒gel route. | Braunite (Mn<sub>7</sub>SiO<sub>12</sub>)‒rhodonite (MnSiO<sub>3</sub>) nanocomposites have been synthesized utilizing a green aqueous citrate sol‒gel route. The influence of heat-treatment temperature on the structure and properties of these nanocomposites was investigated. X-ray diffraction and high resolution transm... |
41994835 | In Silico Destructive Activity of Phytochemicals From Ocimum sanctum Against the T9SS Proteins of Porphyromonas gingivalis. | Periodontitis is a chronic inflammatory condition closely associated with the pathogenic activity of <i>Porphyromonas gingivalis </i>(<i>P. gingivalis</i>). Among its virulence components, the PorA and PorE proteins play essential roles in the type IX secretion system (T9SS), facilitating the release of gingipain-relat... |
41993624 | Anti-cancer immune priming with β-radioligand therapy using a novel high affinity antibody selectively targeting the 4Ig-Isoform of B7-H3. | <h4>Rationale</h4>Radioligand therapy (RLT) is an emerging oncologic strategy that uses molecularly targeted therapeutic radioisotopes to reduce tumor burden and improve survival in patients with advanced cancers. Expanding RLT to new targets and understanding its systemic immune effects could enhance its clinical impa... |
41983116 | Metal-Coordinated His-Tag Functionalization of Polymeric Nanogels for Therapeutic Applications. | Nanogels (NGs) are versatile polymeric nanocarriers with high drug loading capacity and colloidal stability, making them pivotal candidates for targeted biomedical applications. Surface functionalization with biomolecules is essential for selective targeting therapies; however, conventional covalent conjugation can com... |
41970846 | Development and Validation of an Isocratic HPLC Method for the Simultaneous Determination of Avobenzone and Tris-Biphenyl Triazine. | Avonenzone (AVO) and tris-biphenyl triazine (TBPT) are ultraviolet (UV) filters commonly used in sunscreen formulations. Their combination enables broad-spectrum photoprotection and improved photostability. Despite their widespread and emerging use, the <b>simultaneous quantitative analysis of these highly hydrophobic ... |
41953562 | Mechanism driven adaptation of smart hydrogels to the osteoarthritis pathological microenvironment. | Osteoarthritis (OA) arises from interconnected pathological processes, including persistent inflammation, mitochondrial dysfunction, cartilage matrix degeneration, and abnormal neurovascular remodeling. Current clinical care remains largely symptomatic and targets only a narrow set of mechanisms, which limits modificat... |
41939948 | Zr-based metal-organic frameworks for colorimetric sensing applications. | Zirconium-based metal-organic frameworks (MOFs) possess high porosity, chemical stability, and chemical/structural tunability, making them versatile platforms for colorimetric sensing. This focused review highlights Zr-based MOF applications for the detection of acids and bases, aqueous ions, biomolecules, and volatile... |
41935008 | Multiscale evaluation of metal-organic framework-based adsorbents for shipboard carbon capture: Simulation, experiment, and sustainability analysis. | <h4>Background</h4>Shipboard carbon capture requires adsorbents capable of selectively removing CO<sub>2</sub> from complex exhaust mixtures containing CO, NO, and SO<sub>2</sub> under dynamically varying thermal and pressure conditions. Metal-organic frameworks (MOFs), with their tunable porosity and well-defined stru... |
41923954 | Predicting and Improving the Mechanical Strength of Outer-Skinned Hollow Fiber Membranes. | Pressure-driven hollow fiber (HF) membranes are often operated with the feed on the outside of the HF. In such a configuration, it is important to know the limits of the external pressure that can be applied to the membrane. Therefore, we investigated whether a model for predicting the collapse pressure of isotropic th... |
41909811 | Population HLA coverage of experimentally characterized <i>P. falciparum CD8</i> <sup><i>+</i></sup> T cell epitopes as potential components of a multi-epitope malaria vaccine construct: an <i>in silico</i> insight. | <h4>Objective</h4>Malaria remains a significant global health challenge, with <i>Plasmodium falciparum</i> causing the most severe cases and deaths, particularly in sub-Saharan Africa. An effective universal or pan vaccine is needed to augment current concerted control efforts. This <i>in silico</i> study investigated ... |
41909664 | Integrative pan-cancer analysis of dipeptidyl peptidase 4 with clinical and <i>in vitro</i> validation in prostate cancer. | <h4>Background</h4>Dipeptidyl peptidase 4 (DPP4) plays diverse physiological roles, but its pan-cancer significance and immunomodulatory functions remain poorly characterized.<h4>Methods</h4>We performed an integrative pan-cancer analysis of DPP4, incorporating transcriptomic, genomic, and immunogenomic approaches. Dif... |
41909653 | Protective immunity against Chagas disease induced by a superantigen-based chimeric DNA vaccine delivered by attenuated <i>Salmonella</i>. | <h4>Introduction</h4>Chagas disease is a chronic parasitic infection endemic to Latin America that affects more than 7 million people and is increasingly spreading worldwide due to human migration. <i>Trypanosoma cruzi</i> is the etiological agent of this disease, for which no effective vaccine has yet been approved fo... |
41909121 | Resolving tooth development at single-cell resolution: advancing dental regeneration. | Tooth development is a continuous, highly orchestrated process that serves as an ideal model for dissecting the cellular and molecular mechanisms of organogenesis. In recent years, advances in single-cell transcriptomics have provided unprecedented insights into cellular heterogeneity, lineage trajectories, and molecul... |
41909035 | Vitamin D and exercise in obesity: a neurovascular-muscle axis. | Obesity is characterized by chronic low-grade inflammation, insulin resistance, impaired skeletal muscle function, and disturbances in neurovascular health. Metabolic inflexibility, defined as a reduced capacity to appropriately switch between lipid and glucose utilization in response to physiological demands, represen... |
41908829 | PoMA-10: a dual-action antiviral disrupting SARS-CoV-2 Spike-ACE2 interaction and protecting lung tissue. | This study aimed to identify small molecules that inhibit the binding of the SARS-CoV-2 Spike protein to its host receptor, angiotensin-converting enzyme 2 (ACE2), without impairing the enzymatic activity of ACE2. Such inhibitors may support the development of broad-spectrum antivirals and therapeutic strategies for em... |
41908811 | Thymoquinone combined with conventional antibiotics against pandrug-resistant <i>Staphylococcus aureus</i>: a pharmacodynamic and molecular simulation strategy to overcome bioavailability limitations. | <h4>Background</h4>Infections with pandrug-resistant (PDR) <i>Staphylococcus aureus</i> (<i>S. aureus</i>) present no available treatment alternatives, even when employing most antibacterial combination regimen. Restoring the effectiveness of existing antibiotics especially through the integration of safe plant-derived... |
41908031 | A tonic electrocutaneous stimulation paradigm for graded sensory C-fiber engagement in healthy subjects. | <h4>Introduction</h4>Long-term pain models provide valuable proxies for studying physiological changes associated with chronic pain, which is commonly associated with sustained C-fiber-mediated nociceptive input and central sensitization, and are particularly useful in therapeutic and drug development research. We inve... |
41907745 | A <i>Moringa oleifera</i>-based formulation for growth and mitigation of drought stress in tomato plants. | <h4>Introduction</h4>Contemporary agriculture is undergoing a profound transformation aiming at reducing environmental pollution, improving food security, and tackling the climate crisis. To respond to these challenges, the European Commission launched in 2020 the Green Deal initiative, which has among its main goals f... |
41907628 | Valproate reactivates HTLV-1 tax and reduces ABCB1/MDR1 expression in PBMCs derived from ATLL patients. | Chemoresistance remains a major obstacle to effective treatment and durable remission in leukemia patients. Although initial responses to chemotherapy are often favorable, relapse frequently occurs due to the emergence of drug-resistant malignant clones. Resistance mechanisms may be intrinsic or acquired and involve dr... |
41907509 | Role of metal nanomaterials in wound healing - a review. | Wounds pose a significant burden in a patient's life. Nanotechnology has developed a new era of wound healing through the introduction of nanoparticles. This paper reviews the performance of various metallic nanoparticles, like silver, gold, titanium, magnesium, cerium, and zinc in bacterial reduction, inflammation con... |
41907287 | Non-signaling protein therapeutics: a mechanism-based regulatory framework to modernize biosimilar development and global harmonization. | Non-Signaling Protein Therapeutics (NSPTs) represent a proposed regulatory category for biological products whose therapeutic effects operate through ligand neutralization, complement cascade blockade, or other non-signal-transducing mechanisms rather than receptor-mediated signaling. These products exhibit bounded bio... |
41907243 | Dysregulated metabolic homeostasis as a unifying death mechanism underlying the diverse clinical manifestations of COVID-19: insights from a retrospective analysis of sequential blood variables. | <h4>Background</h4>COVID-19 presents diverse clinical manifestations associated with increased mortality, yet a unifying death mechanism remains elusive; here, we suggest such a mechanism that implies a simple way to lower deaths. This work differs from previous studies that use machine learning to identify mortality p... |
41907112 | Advancing biomedical technology through multifunctional porphyrin-based MOFs: design principles, applications, and biosafety evaluations. | Porphyrin-based metal-organic frameworks (MOFs) have a great deal of promise for widespread use in biomedical and nanomedical fields because of their exceptional structural and functional properties, good biosafety and low toxicity, and intrinsic biodegradability. This review systematically outlines the design principl... |
41902257 | Identification of a Key Hemagglutinin Mutation Mediating Antibody Escape in Influenza A(H1N1)pdm09 Viruses. | <h4>Background</h4>The H1N1 influenza A virus evades host immunity through continuous antigenic drift, posing a significant challenge to broad-spectrum neutralizing antibody therapies. This study aims to systematically evaluate the neutralizing capacity of the broad-spectrum antibody C12H5 against H1N1 strains from dif... |
41901957 | Effect of the Chemical Structure of Modifiers Used in the Receptive Membrane of an Umami Taste Sensor on Its Electrical Responses. | In our previous study, a taste sensor employing a lipid/polymer membrane modified with 2,6-dihydroxyterephthalic acid (2,6-DHTPA) enabled the detection of the umami substances monosodium glutamate (MSG) and inosinate monophosphate (IMP). The taste sensor was also able to evaluate the synergistic effect, an umami enhanc... |
41901610 | Differentiating Early Alzheimer's Disease from MCI Using Comprehensive Semiquantitative Parameters in Dual-Phase Amyloid PET: A Pilot Study. | <i>Background and Objectives</i>: Dual-phase amyloid PET imaging has been proposed to provide complementary information regarding amyloid burden and cerebral perfusion. This exploratory pilot study evaluated whether semiquantitative parameters derived from dual-phase PET/CT could differentiate individuals operationally... |
41901311 | Recent Advance in the Sample Pretreatments for Drug Analysis in Zebrafish. | Zebrafish, as an emerging model organism, are widely used in in vivo pharmacodynamic and pharmacokinetic studies. Unlike direct chemical analyses that require no sample preparation, most biological samples must undergo preprocessing steps-procedures that profoundly affect analytical outcomes. This paper systematically ... |
41901082 | Dietary Bioactives in Alzheimer's Disease: A Critical Appraisal of Clinical Trials and Future Nutritional Strategies. | <b>Background:</b> Alzheimer's disease (AD) remains a major public health challenge. Observational associations between dietary patterns and reduced dementia risk have prompted investigations of dietary bioactives (DBs) as cognitive nutraceuticals. <b>Methods:</b> This critical narrative review examines interventional ... |
41900838 | Sodium Alendronate-Modified PLGA-mPEG Nanomicelles Loaded with Rifapentine for Targeted Delivery to Bone Tissue. | <b>Background/Objectives:</b> The limited targeting efficiency and systemic toxicity of conventional medicine present significant challenges in the treatment of skeletal disorders, such as bone tuberculosis. To address these limitations, we developed a bone-targeting nanomicelle delivery system functionalized with alen... |
41900837 | PLGA-Based In Situ-Forming Implants, a Quality by Design Perspective. | In situ-forming implants (ISFIs) based on poly(lactic-co-glycolic acid) (PLGA) offer a promising platform for long-acting parenteral drug delivery, enabling minimally invasive administration without surgical implantation. However, the development and clinical translation of PLGA-based ISFIs are hindered by formulation ... |
41900597 | Fabrication and Characterization of Fish Tropocollagen Sponge Enriched with Nanodiamonds for Potential Wound Dressing Applications. | The development of collagen-based composite materials offers new opportunities for designing bioactive porous structures with tunable properties. This study focuses on sponges or scaffolds fabricated from fish skin-derived tropocollagen combined with detonation nanodiamonds (NDs), aiming to explore how incorporation of... |
41900403 | Integrated Metagenomic and Metabolomic Analyses Reveal Rhizosphere Soil Microecological Changes in <i>Thlaspi arvense</i> L. Lines with Different Alkaloid Contents. | Pennycress (<i>Thlaspi arvense</i> L.), a representative and economically valuable cover crop, supports and enhances key ecological processes throughout its life cycle via its root system. It is hypothesized that pennycress selectively modulates its rhizosphere microbial community through root-derived metabolites, whic... |
41900400 | Periodontal Disease and Its Association with <i>Porphyromonas gingivalis</i>: Current Understanding of Microbial Dysbiosis, Immunopathology and Immune Evasion. | <i>Porphyromonas gingivalis</i> is described as a keystone pathogen associated with periodontal disease (PD), which exhibits enhanced representation upon microbial dysbiosis in such a chronic inflammatory disease. This oral pathogen drives and contributes to a dysregulated immune response, resulting in stages of aggres... |
41900055 | Core-Shell Metal-Organic Framework Composites: A Review of Synthetic Strategies and Applications in Catalysis and Adsorption. | Core-shell metal-organic framework (MOF) composites, owing to their unique structural advantages, have emerged as a prominent research focus in the field of chemistry, advanced materials and chemical engineering. By integrating MOFs with other functional components such as MOFs, covalent organic frameworks (COFs), meta... |
41900057 | Efficient Approaches to Six-Membered Polyazacyclic Compounds-Part 3: C-H Functionalization of Heterocycles. | The review summarizes the literature data on the C-H functionalization of six-membered polyaza heterocycles, specifically diazine and triazine skeletons, which are important in medicine and pharmacology, as examples. The analysis covers the works published mainly over the last 20 years. The review focuses on strategies... |
41900049 | The Hidden Threat of Pharmaceuticals: Ketoprofen Degradation and Toxicity to Non-Target Organisms. | Ketoprofen is a widely prescribed non-steroidal anti-inflammatory drug whose extensive global use, combined with limited biodegradability, has led to its increasing detection as a micropollutant in aquatic and terrestrial environments. Incomplete removal during wastewater treatment results in its continuous release int... |
41900058 | Exceptional Hydrogen Storage Performance of Ti-Decorated C<sub>3</sub>B<sub>2</sub> Quantum Dot: A Comprehensive First-Principles Study. | The development of lightweight materials with high and reversible hydrogen storage capacity remains a key materials design challenge. Here, we investigate pristine and Ti-decorated C<sub>3</sub>B<sub>2</sub> quantum dots using DFT, DLPNO-CCSD(T), and statistical thermodynamics. Pristine C<sub>3</sub>B<sub>2</sub> stron... |
41899095 | Resistance to Targeted Therapy in AML: Current Challenges and Emerging Treatment Strategies. | The development of targeted treatments, including inhibitors of BCL-2, FLT3, IDH1/2, and menin, has significantly expanded the therapeutic landscape of acute myeloid leukemia (AML), offering more personalized and molecularly driven treatment approaches. Despite these advances, achieving durable responses represents a m... |
41898461 | Molecular Mechanisms of Islet Amyloid Polypeptide Aggregation: Towards Chemical Strategies to Prevent Amyloid Formation and to Design Non-Aggregating Peptide Therapeutics. | The islet amyloid polypeptide (IAPP) is a peptide hormone playing key biological roles, including glucose homeostasis and regulation of food intake, conferring high therapeutic potential to treat metabolic disorders. Nonetheless, IAPP is mainly known as the major component of the amyloid fibrils observed in the pancrea... |
41898454 | Gradual Morphological Tuning in Polymer Microspheres via Pickering Emulsion Synthesis: Architecture-Controlled Dye Adsorption and Encapsulation. | Polymeric microspheres synthesized via Pickering emulsion polymerization offer structural tunability, making them attractive platforms for dye adsorption. This study investigates the adsorption behavior of methylene blue onto two classes of polymeric microspheres-poly(methacrylic acid) crosslinked with ethylene glycol ... |
41898455 | Special Issue "Molecular Scale Design, Synthesis, and Application of Macroporous, Mesoporous, and Microporous Materials". | The aim of this Special Issue is to emphasize the significance of molecular-scale design, synthesis, and application of macro-, meso-, and microporous materials in order to achieve optimal performance across diverse fields [...]. |
41898453 | The Role of 3D Printing in Regenerative Medicine: A Game-Changer in Tissue Engineering. | In regenerative medicine, three-dimensional (3D) printing provides precise spatial control over the fabrication of complex, biomimetic tissue constructs, enabling the production of architecturally defined and functionally tailored scaffolds. By enabling precise layer-by-layer deposition of cells, biomaterials, and bioa... |
41898291 | Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications. | In recent years, there has been a growing scientific and clinical interest in nutraceuticals, bioactive compounds derived from natural sources such as plants, fruits and cereals. These substances have gained prominence due to their diverse pharmacological properties, particularly their anti-inflammatory, antioxidant an... |
41897861 | Application of the "Yuyang Muxin" Breeding Chip in Huang-Huai Sheep: A Six-Year Comprehensive Evaluation of Production and Meat Quality Traits. | The Huang-huai sheep (Dorper × Small-tailed Han), certified in China in 2019, initially exhibited issues with genetic uniformity and meat quality. A six-year (2020-2025) breeding program was conducted at two core farms (collectively housing ~2400 breeding ewes representing 12 bloodlines) using the custom "Yuyang Muxin"... |
41897356 | Natural Products Targeting PAD4 in NETosis: Structural and Mechanistic Insights into Direct and Indirect Inhibition. | Peptidyl arginine deiminase 4 (PAD4) is a Ca<sup>2+</sup>-dependent enzyme that catalyzes histone citrullination and plays a central role in chromatin decondensation during neutrophil extracellular trap (NET) formation. Dysregulated PAD4-mediated NETosis contributes to the pathogenesis of diverse inflammatory and immun... |
41893516 | Advances in Elucidating the Mitochondrial DNA Mechanisms Underlying Ozone-Induced Inflammation. | Ground-level ozone is widely acknowledged as one of the primary air pollutants, capable of inducing adverse health effects across multiple human systems, including asthma, cardiovascular events, and central nervous system dysfunction. Epidemiological and toxicological studies indicate that the onset of related systemic... |
41893198 | Therapeutic Biomaterials for Chronic Osteomyelitis: Time-Space-Control Strategies for Infection Control and Bone Repair-A Narrative Review. | Chronic osteomyelitis and infected bone defects are driven by recurrent infection, biofilm persistence, and dysregulated inflammation, but conventional "eradicate bacteria and fill the defect" approaches often fail to restore a regenerative microenvironment. Herein, we review biofilm-associated immune dysfunction in im... |
41892555 | Stimuli-Responsive Hydrogels in Food Sector: Multi-Component Design, Stimulus-Response Mechanisms, and Broad Applications. | Hydrogels are endowed with exceptional hydrophilicity and biocompatibility by their network structure, while also exhibiting soft physical properties similar to living tissues, which renders them ideal biomaterials. Responsive hydrogels-particularly those constructed from multicomponent systems including proteins, poly... |
41892553 | Protein-Directed Nucleation and Stabilization of Ultrasmall Silver Nanoparticles Within BSA Hydrogels. | Biocompatible nanocomposite hydrogels are emerging as versatile platforms in nanomedicine, particularly when natural proteins are used as both structural and chemical components. In this work, we report a green, simple, and rapid in situ synthesis of ultrasmall silver nanoparticles (uAgNPs) within a bovine serum albumi... |
41892293 | Microglial-Targeted GCPII Inhibition Reverses Neurocognitive Impairment and Synaptic Loss After EcoHIV Infection. | HIV-associated neurocognitive impairment persists despite combination antiretroviral therapy, largely driven by chronic microglial activation that sustains neuroinflammation and neuronal injury. Activated microglia contribute to HIV-associated brain pathology by releasing proinflammatory mediators that disrupt synaptic... |
41889775 | Carrier-Free Enzyme Immobilization for High-Density Catalytic Architectures in Flow Biocatalysis. | Carrier-free enzyme immobilization has become a central design concept for constructing high-density catalytic architectures in flow biocatalysis. This Perspective discusses the evolution of such materials from early cross-linked enzyme aggregates and crystals to biologically derived inclusion bodies, all-enzyme hydrog... |
41861746 | Metal-organic frameworks for food safety monitoring: advances in sensing exogenous contaminants. | The rapid, sensitive detection of foodborne contaminants is essential for food safety and public health. Metal-organic frameworks (MOFs) have emerged as leading sensing materials due to their tunable porosity, high surface area, abundant active sites, and versatile physicochemical properties. Recent advances in MOF-bas... |
41859730 | Heterologous expression of hagfish thread proteins EsTKα and EsTKγ in <i>Pichia pastoris</i> and in vitro self-assembly into an ordered fibrous network. | <i>Eptatretus stoutii</i> thread keratin α and γ (EsTKα and EsTKγ) are essential structural components conferring hagfish slime with exceptional strength and toughness. These proteins exhibit exceptional mechanical properties, rendering them promising candidates for biomimetic material applications. However, the abilit... |
41859675 | Retraction Notice to "Effect of subcutaneous lidocaine-hydroxypropyl-β-cyclodextrin (HP-β-CD) on quality of life in patients with post-COVID condition: a 36-week observational interrupted time series study" [eClinicalMedicine 90(2025) 103681]. | [This retracts the article DOI: 10.1016/j.eclinm.2025.103681.]. |
41859515 | Peptide-directed folding of the elusive RNA i-motif. | Folded RNA structures are increasingly being recognised as key regulators in biological processes, yet the RNA i-motif remains poorly characterised due to its low stability and lack of selective molecular probes. Here, we describe the first ligand - a short peptide - that binds the elusive RNA i-motif. Our minimalist p... |
41858728 | Chronic inflammation-responsive hydrogel restores myeloid-T cell crosstalk to reinvigorate antitumor immunity against metastatic colorectal cancer. | Chronic inflammation in intermediate/advanced tumors drives burdensome protumor immune cell communication, thereby weakening immunotherapy. Conventional anti-inflammatory therapies focus on alleviating chronic inflammation whereas ignore dysfunction and scarcity of myeloid and T cells, which hinder their intercellular ... |
41855826 | Computational study of the mass transfer effects in metal-organic framework columns for liquid chromatography. | We present an in-depth theoretical study of the band broadening processes originating from the specific shape and intra-particle diffusion characteristics of metal-organic framework (MOF) particles used in high-performance liquid chromatography (HPLC). Studying perfectly ordered packings, the complex nature of the eddy... |
41849851 | High-entropy metal-organic framework as an efficient fiber coating for headspace solid-phase microextraction of polychlorinated biphenyls. | Inspired by their abundant coordination-unsaturated metal sites and hierarchical pore structure, high-entropy metal-organic frameworks (HE-MOFs) were fabricated and firstly applied in solid-phase microextraction (SPME), and exhibited outstanding extraction performance for polychlorinated biphenyls (PCBs) pollutants. Th... |
41847179 | Nanotechnology-Enabled Diagnosis and Treatment of Hepatocellular Carcinoma: Theranostics, Combination Regimens, and Translation. | This manuscript explores the innovative application of nanotechnology in the diagnosis and treatment of hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality worldwide. Emphasizing the synergistic potential of nanotechnology, the paper discusses advanced nanomaterials and techniques, such as targe... |
41847150 | Advances in detecting category A biothreat agents: Toward symptom-driven sensing strategies. | The rise of emerging technologies like synthetic biology and artificial intelligence has raised alarms about new forms of weaponized diseases, given their threat to life and societal economic burden. This underscores the critical role of developing sensor technologies for countermeasures. This review focuses on the lat... |
41847095 | Two-Dimensional MXenes as Next-Generation Nanomaterials for Biosensing and Hydrogen Production. | The discovery of graphene, which has led to further research on other two-dimensional (2D) materials, has greatly enhanced the development of sustainable novel materials in the age of nanotechnology. The majority of elements in the periodic table are currently converted into 2D forms by researchers. Materials such as g... |
41844462 | Introducing an ultrasensitive glutathione nanozymatic biosensor developed by a novel MOF-nanozyme with intrinsic peroxidase-like activity. | An ultrasensitive glutathione nanozymatic biosensor developed by a novel MOF-nanozyme was introduced. Initially, the MOF-nanozyme was characterized for its enzyme-like activity and chemical/biochemical characteristics. A working pH range of 4.0-7.0, cycling stability of at-least 15 cycles, high thermo-stability (93.7%,... |
41839468 | Mutation-driven adaptation of ACE2-RBD binding revealed by integrative molecular dynamics analysis. | Investigating the effects of residue-level variations in the receptor-binding domain (RBD) of the SARS-CoV-2 influence the molecular recognition and binding behavior toward the human ACE2 protein is essential for elucidating viral evolution and transmissibility. Earlier structural and computational analyses have provid... |
41837159 | Fmoc-Phe : Fmoc-Leu supramolecular hydrogels with adaptive antibacterial activity. | The development of adaptive soft materials offers new opportunities to address the effects of antimicrobial resistance. Fmoc-phenylalanine (Fmoc-Phe) and Fmoc-leucine (Fmoc-Leu) based hydrogels are known to demonstrate antibacterial activity. We now show that by combining these two gelators (Fmoc-Phe and Fmoc-Leu) into... |
41836639 | Microneedles meet photomedicine: emerging strategies for diagnosis and therapy of skin diseases. | Microneedle technology, a minimally invasive transdermal delivery platform, has attracted increasing attention in dermatology due to its ability to bypass the first-pass effect, reduce injection-associated pain, and achieve precise targeting in the diagnosis and therapy of skin diseases. Beyond drug transport, MNs can ... |
41833083 | Ultrasensitive photoelectrochemical aptasensor for sulfadiazine detection enhanced by taxifolin-boosted 3D porous g-C<sub>3</sub>N<sub>4</sub>. | Photoelectrochemical (PEC) sensing based on graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>) has promising attention due to its low background signal; however, its performance is hindered by charge carrier recombination. Herein, a high-performance PEC aptasensor was developed for ultrasensitive sulfadiazine (SDZ... |
41832851 | Highly stable and selective flexible sweat sensor combined with bioinspired microfluidic chip: Zn-Ni bimetallic MOF-driven noninvasive renal function assessment. | To enable non-invasive, dynamic renal function monitoring, this study pioneered a flexible wearable platform integrating high-sensitivity sensing materials and an efficient sweat transport system. A flexible creatinine sensor (CrS) was fabricated with Zn-Ni bimetallic MOF (Ni/Zn = 3:1), COOH-CNT, and LIG interdigitated... |
41831746 | Bone strain index improves 10-year fracture risk prediction beyond bone mineral density and FRAX® in community-dwelling older women: A study of the FRISBEE cohort. | <h4>Objectives</h4>The Bone Strain Index (BSI), derived from finite element analysis of DXA, quantifies mechanical strain within bone. Its predictive value for fragility fractures in older women remains to be established in large prospective studies.<h4>Methods</h4>This prospective cohort study assessed the association... |
41831292 | Development of biosafe MOF-based highly sensitive carboxymethyl cellulose interpenetrating gelatin network smart freshness aerogel tags for real-time graded shrimp freshness monitoring. | With the growing demand for food freshness, developing ammonia-sensitive smart tags for real-time monitoring of animal-derived foods has become increasingly important. In this study, we successfully synthesized Biosafe-MOF nanocrystals with excellent ammonia sensitivity and incorporated them into gelatin/carboxymethyl ... |
41821271 | Initial Aggregation Process of Thickener in Lithium Soap Greases: All-Atom Molecular Dynamics Simulation. | Grease is an organogel consisting of low molecular mass gelators that exhibit self-assembly. We performed all-atom molecular dynamics simulations of two types of lithium soaps, lithium stearate (LiS) and lithium 12-hydroxystearate (Li12HS), in hexane as a solvent to investigate the aggregation process. We found that th... |
41821243 | Engineered Bacteria-Driven Biohybrid Microrobots Potentiate IL-2 Immunotherapy by Evoking Pyroptosis. | Interleukin-2 (IL-2) immunotherapy offers considerable potential for metastatic cancers; however, its efficacy is limited by low response rates, dose-dependent toxicity, short half-life, poor tumor accumulation, and off-target immune activation. In this work, we present a biohybrid microrobot (IL-2@Z/C/A) engineered th... |
41820978 | Rapid identification of antigen-specific monoclonal antibodies from HIV-1 elite controllers using the Beacon platform. | Elite controllers (ECs) are rare human immunodeficiency virus (HIV)-infected individuals who manage viral replication without antiretroviral therapy. While their cellular immunity is well characterized, humoral responses remain limited, which provides an uncommon window into antibody responses to HIV-1. Using single-ce... |
41820664 | Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo. | Tissue clearing has been widely used for fluorescence imaging of fixed tissues, but its application to live tissues has been limited by toxicity. Here we develop minimally invasive optical clearing media for fluorescence imaging of live mammalian tissues. Light scattering is minimized by adding spherical polymers with ... |
41820630 | Predictive value of BMD for hip and other fractures: a meta-analysis to update FRAX. | The relationship between bone mineral density (BMD) at the femoral neck and fracture risk was determined in a meta-analysis of primary data of 307205 men and women from 53 cohort studies. Low BMD was an important predictor of fracture risk, particularly for hip fracture.<h4>Introduction</h4>This study aimed to quantify... |
41820386 | XA-Novo: high-throughput mass spectrometry-based de novo sequencing technology for monoclonal antibodies and antibody mixtures. | Elucidating antibody sequences by mass spectrometry-based de novo sequencing is essential but remains technically challenging. Here we present XA-Novo, an accurate and high-throughput de novo sequencing solution that integrates a single-pot multi-enzymatic gradient digestion method with a beam search-based assembler (F... |
41820292 | Harnessing pyroptosis in breast cancer therapy: immunological mechanisms and emerging biomaterial strategies. | Breast cancer is a complex and predominant long-term medical condition in women. Its complexity is related to its diversity, variable clinical outcomes, and resistance to standard treatments, emphasizing the need for novel treatment strategies. Pyroptosis is a lytic and inflammatory programmed cell death regulated by t... |
41820264 | Au-Coordinated Motifs with Optimization of Electronic Structure and Hydrogen Bond Network in Zr-Based Metal-Organic Frameworks for Enhanced Photocatalytic Hydrogen Evolution. | Metal-organic frameworks (MOFs) have emerged as prospective candidates for photocatalytic hydrogen evolution, yet their efficiencies are still limited by insufficient charge carrier utilization and a high energy barrier for proton transfer and reduction. In this study, we molecularly engineered the Au-coordinated motif... |
41820017 | Dehydration-driven organization of metabolites into NaDES-like assemblies in orthodox seeds. | Desiccation tolerance in plants, especially during orthodox seed dehydration, relies on compatible solute accumulation, complex molecular mechanisms, and intermolecular organizations that remain poorly understood. We combined metabolite profiling, mass spectrometry imaging, and electrospray and cold-spray ionization ma... |
41818804 | Polyaniline-Encapsulated MIL-100 (Fe) MOF Composite as a Robust Modifier to Enhance the Performance of Nanofiltration Membranes for Desalination and Wastewater Treatment. | Mixed matrix membranes (MMMs) are widely explored to overcome the permeability-selectivity trade-off that limits conventional nanofiltration membranes. In this work, poly(ether sulfone) (PES)-based nanofiltration MMMs were fabricated by incorporating a polyaniline (PANI)-encapsulated MIL-100(Fe) composite as a function... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.