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41818772 | Anthracene-Functionalized Terbium-Organic Framework for Luminescent Sensing and Adsorptive Removal of Aqueous Pollutants. | The detection and removal of heavy metal ions and organic dyes in wastewater are crucial yet highly challenging. Herein, we report a stable terbium-based metal-organic framework, <b>LCUH-125</b>, assembled from Tb<sup>3+</sup> ions and an anthracene-containing aromatic carboxylic acid ligand. <b>LCUH-125</b> features a... |
41818753 | Encapsulation of Fe<sub>3</sub>O<sub>4</sub> and Lipase in a Squarate Metal-Organic Framework for Nonaqueous Catalysis. | Enzyme immobilization in metal-organic frameworks (MOFs) has emerged as a promising strategy to enhance the stability and reusability of biocatalysts. However, maintaining high enzymatic activity, especially in nonaqueous media, remains a challenge. Herein, we report a facile one-pot in situ encapsulation strategy to c... |
41818728 | Host-Guest Interactions Enhance Charge Transport across Single Cyclodextrin/Azobenzene Complex Junction. | While azobenzene has been studied extensively for its single-molecule charge transport properties, its complexation with guest ring molecules may significantly influence charge transport that is not yet well understood. In this work, we study the influence of host-guest interactions between α-cyclodextrin (α-CD) and az... |
41818726 | Vacuum Applications of Ionic Liquids: Fundamentals, Processing, and Emerging Interfaces. | Before ionic liquids (ILs) gained popularity, liquids had been rarely used in most vacuum processes because of their nature of volatility and outgassing. ILs can remain in liquid state in high vacuum and have paved a new frontier of vacuum engineering for liquidus interfaces and related nanostructures. This review synt... |
41818615 | Fast Generation of Simulation-Quality Structural Ensembles of Mixed-Chirality Cyclic Peptides via Diffusion Models. | Cyclic peptides are an emerging therapeutic modality, with recent computational efforts focusing on the design of cyclic peptides that predominantly adopt a single conformation. However, many cyclic peptides adopt multiple conformations in solution, existing as structural ensembles. This conformational flexibility is o... |
41818608 | Biomimetic Cell Membrane-Coated MOFs System for Targeted Cancer Therapy. | The integration of metal-organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine. In this review, we systematically summarized recent advances in cell membrane-camouflaged MOF as drug delivery systems, focusing on their uni... |
41818492 | Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin-Like Peptide in Bactrocera Dorsalis. | Feeding in animals is primarily regulated by the internal satiety state. Sulfakinin (Sk) is well known as a satiety signal that inhibits feeding. However, the underlying mechanism activating the Sk release is not yet fully understood, although the Sk for inhibitions of peripheral sensory systems, gustatory sweet and ol... |
41818440 | Machine-Learning and Atomic-Scale Mechanistic Insights for Designing Gradient Porous MOF-Derived Carbon Electrodes. | MOF-derived heteroatom-doped porous carbons hold strong potential for supercapacitor electrodes, yet their optimization is hindered by complex coupling among pore geometry, composition, and electrochemical behavior. To clarify these structure-performance relationships, we establish a predictive design strategy by integ... |
41818432 | A missense mutation in the bovine <i>NPBWR2</i> gene introgressed from <i>Bos javanicus</i> into Chinese indicine cattle. | Neuropeptide B/W receptor-2 (<i>NPBWR2</i>) is a G protein-coupled receptor which is related to the regulation of feeding behavior, energy homeostasis, neuroendocrine function, and inflammatory pain. In addition, it plays a potential role in the regulation of stress, emotion, anxiety and fear responses. Interestingly, ... |
41818417 | Water-Mediated Electronic Modulation in Boron-Nitrogen Multi-resonance Thermally Activated Delayed Fluorescence Emitters. | Using the prototypical "multiple resonance" (MR) emitters CzBN and BCzBN (also known as DtBuCzB), we uncover a previously unrecognized yet crucial complexation process between B/N MR cores and water molecules that profoundly alters their ground- and excited-state photophysics and photochemistry. This discovery originat... |
41818411 | An Amino-Acid-Derived Metal-Organic Framework with Large Pores for Unspecific Enantioseparation. | The selective separation of enantiomers is critical in pharmaceutical production, while conventional chiral sorbents always suffer from the trade-off between selectivity and the substrate scope. Herein, inspired by a natural unspecific peroxygenase with large protein channels, we developed a homochiral metal-organic fr... |
41818409 | Ru(III)-Modified Trinuclear Nickel Cluster Metal-Organic Framework as a Bifunctional Electrocatalyst for Selective Benzyl Alcohol Oxidation and Accelerating Hydrogen Evolution. | Nickel-based materials, due to their low cost, high activity, and dual-function characteristics, have become the most promising catalyst system in the field of biomass electrocatalytic conversion coupled with hydrogen production. The activity of the catalyst and the selectivity of the reaction still present significant... |
41818265 | Determinants of natural killer cell-mediated antibody dependent cellular cytotoxicity in SARS-CoV-2 antibodies. | A growing body of evidence underscores the role of antibody-dependent cellular cytotoxicity (ADCC) in antiviral immunity. Yet, the mechanisms underlying the ability of certain antibodies (Abs) to mediate potent ADCC activity remain poorly characterized. In particular the contribution of features within the antigen-bind... |
41818135 | Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons. | Cholesterol, abundantly present in distinct plasma membrane pools, is a critical modulator of ion channel function, including hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that regulate the excitability of dorsal root ganglion (DRG) nociceptor neurons. Depletion of membrane cholesterol potentiated ... |
41818024 | A Deep Learning Approach for Dynamic Modeling of Stimulated Raman Scattering in Chalcogenide Microstructured Optical Fibers. | Stimulated Raman scattering (SRS) plays a pivotal role in applications such as optical communications, fiber optic sensing, and spectral analysis. However, traditional modeling methods like the split-step Fourier method (SSFM) are computationally demanding. In response to these challenges, we propose a novel deep learn... |
41817770 | Decoding Cdk1 control: from mitotic thresholds to meiotic specificity. | The eukaryotic cell cycle is one of the most fundamental biological processes, ensuring the accurate duplication and segregation of the genome during mitosis. Decades of research across model systems have shown that this process is orchestrated by a family of protein kinases known as cyclin-dependent kinases (Cdks). To... |
41817639 | Redox Noninnocence in First-Row Transition Metal Complexes of a π-Extended β-Diketiminate. | The synthesis and characterization of a series of complexes featuring a π-extended benzo[<i>f,g</i>]tetracene β-diketiminate (BT-BDI) ligand is presented. The homoleptic iron(II), cobalt(II), nickel(II), and zinc(II) complexes are synthesized by reaction of the metal dichlorides or dibromides with the potassium salt of... |
41817008 | 3D-Printed Metal-Supported MOF-Heteropoly Acid Nanozyme for High-Performance Peroxidase-Mimic Activity and Ultra-Sensitive Glucose Detection. | The development of nanozymes combining high catalytic activity, mechanical robustness, and scalable fabrication is crucial for next-generation biomedical sensing. However, most current 3D-printed diagnostic platforms rely on polymeric substrates that suffer from limited reusability, weak mechanical strength, and poor l... |
41816878 | Shear-Induced Anisotropic Supramolecular Gel Noodles for Improved Cell Guidance in Polarized Tissue Engineering. | Tissue engineering and regenerative medicine applications require the integration of multifunctional materials, offering tissue-specific mechanical cues and geometric guidance to support cell differentiation. In this context, supramolecular gel noodles formed by ionic cross-linking of pre-assembled micellar networks of... |
41816859 | Supramolecular Control of Photoinduced Electron Transfer between Tungsten Halide Clusters and Polyoxometalates in Water. | Identifying systems composed of earth-abundant elements capable of photoinduced electron-transfer represents a major breakthrough for the development of sustainable photocatalytic processes. Herein, we demonstrate that octahedral tungsten-halide clusters constitute a promising new class of robust photosensitizers, owin... |
41816845 | Nitroreductase-Responsive Oligomeric crRNAs for Enzyme-Triggered Regulation of CRISPR Activity. | Hypoxic tumors overexpress nitroreductase (NTR), providing an endogenous trigger for selective biomolecular activation. Here, we describe the synthesis of NTR-responsive clustered regularly interspaced short palindromic repeats (CRISPR) guide RNAs via the site-specific incorporation of a <i>p</i>-nitrobenzyl (<i>p</i>-... |
41816834 | Self-Regulating Hydrogel Driven by Light-Responsive Glyco-Supramolecular Reassembly. | Light-responsive supramolecular materials that operate autonomously represent a key step toward smart, energy-efficient systems. Yet, achieving intrinsic reversibility without external triggers is rare. Here, we present two azobenzene-glycoconjugate amphiphiles bearing glucose (Glc-Azo) or maltose (Mal-Azo) headgroups ... |
41816804 | Interfacial Self-Assembly-Assisted Nanoparticle Imprinting of Plasmonic Gratings with Particle-Level Precision for Dynamic Flexible Holographic Displays. | Plasmonic nanogratings with structural color and diffraction capabilities are essential components of metasurface-based optical systems. However, current methods for fabricating high-fidelity nanograting pixels remain limited in scalability, material compatibility, and adaptability to curved or flexible surfaces. Herei... |
41815083 | Laser-Induced Porosity Engineering of Metal-Organic Frameworks for Enhanced CO<sub>2</sub>/CH<sub>4</sub> Adsorption Properties. | Effective adsorption separation of CO<sub>2</sub>/CH<sub>4</sub> requires porous materials with high porosity and tunability, such as metal-organic frameworks (MOFs). However, structural defects and high production costs often limit their practical application. Here, we propose a laser-induced post-synthetic modificati... |
41815046 | Substrate Induced Regulation of Rigidity of G4-Hydrogels: Toward Peroxidase-Mimic Facilitated Eradication of Fungi via Turning a Metabolic Friend to a Foe. | The necessity of eliminating fungal infections is vital, given their significant mortality rates, particularly among immunocompromised individuals. Proper care and control of Candida-related infections are essential to prevent the emergence and spread of drug-resistant strains, emphasizing the urgency of developing eff... |
41815038 | Subphthalocyanine Platform for Single-Molecule Machines on Surface: Ligand-Directed Adsorption on Au(111). | For the development of single-molecule machines on surfaces, a vertical molecular geometry based on a simple, common platform is a promising design approach. This could allow decoupling of the active unit from the supporting surface and obtaining of a flexible modular system. An ideal platform for this purpose is subph... |
41815006 | Direct Selection of Functional De Novo Macrocycles for Activation of On-Cellulo Insulin Receptor. | The integration of mRNA display with genetic reprogramming, known as RaPID (Random non-standard Peptides Integrated Discovery) system, has emerged as a promising platform for nonstandard peptide screening. The RaPID system relies on mRNA display of macrocyclic peptides which employs affinity-based in vitro selection ag... |
41814989 | Generation of Naphthalenediimide(II) Dianion in a Solid-State Regular π-Stacked Electron-Donor/Acceptor Coordination Polymer Enabled by Photochemistry. | Photoinduced electron transfer (PET) for the generation of the naphthalenediimide dianion (NDI<sup>2</sup> <sup>-</sup>) in a solid-state, regular π-stacked electron donor/acceptor coordination polymer (D-A CP) is described, representing the first report of the photochemically driven synthesis of NDI<sup>2</sup> <sup>-... |
41814971 | Dissipatively Fueled Unidirectionally Communicating DNA Circuits That Control Biocatalysis. | Unlike most synthetic systems, life constantly reorganizes itself through the irreversible consumption of energy-rich molecules and exhibits dynamic functionalities governed by spatiotemporally controlled biocatalytic processes. Inspired by this, we herein demonstrate unidirectionally communicating, out-of-equilibrium ... |
41814968 | Unveiling Zeolite-Confined Aromatic-Water Dynamic Interplay in Methanol-to-Olefins Catalysis. | Water-induced structural dynamics of zeolite framework have been extensively explored in binary model systems comprising only water and zeolites. However, under practical zeolite catalytic systems, water coexists with organic guest molecules within the confined microporous environment, giving rise to dynamical and mult... |
41814965 | Geometry-Programmable Light-Driven Silicon Microrobots. | Light-driven micro/nanorobots (LMNRs) offer on-demand propulsion governed by light direction, wavelength, and polarization, yet their architectures and navigation behaviors have been constrained by limited fabrication strategies. Here, we present a general and scalable strategy for geometry-programmable silicon LMNRs b... |
41814961 | Captodative Radicals Coupling Into Homochiral Molecular Nanotubes With Conglomerate Crystallization. | Chiral macrocycles featuring cyclic skeletons, intrinsic chiral cavities, and unique guest binding properties have aroused considerable interest due to their promising applications in enantioselective recognition, asymmetric catalysis, et al. Nevertheless, the design and synthesis of new chiral macrocyclic architecture... |
41814954 | Surface-Capped Protein Nanoparticles for Nonviral Gene Delivery. | Developing simple, safe, and efficient nonviral delivery systems remains a significant challenge in bioengineering. Nanoparticles offer promising gene delivery capabilities with reduced toxicity; however, long-standing challenges related to effective plasmid encapsulation and delivery exist. Here, we report a novel pro... |
41814881 | Time-Resolved Photochromic Ionic Hydrogen-Bonded Organic Frameworks for Multimodal Advanced Information Protection. | Stimuli-responsive luminescent materials have strong attraction in the field of information anticounterfeiting encryption due to their unique response characteristics. Introducing a time-resolved strategy can expand the encryption dimension from static localized variables to dynamic spatial stereoscopic evolution, achi... |
41813793 | Foot-and-mouth disease virus-derived dendrimer peptides induce germinal center-dependent antibody responses and IgG1 plasma cell differentiation in mice. | Our previous findings demonstrated that the B<sub>2</sub>T dendrimer peptide, harboring B- and T-cell foot-and-mouth disease virus (FMDV) epitopes, confers protection in swine and elicits in mice significant levels of neutralizing antibodies, a key correlate of protection against FMDV. Here, we use a mouse model to stu... |
41755756 | Potassium-ion-responsive chiral supramolecular hydrogels exhibiting long-range chirality transfer from D- or L-alanine to achiral frameworks. | Applying vibrational circular dichroism (VCD) spectroscopy, we directly reveal hydrated-state supramolecular chirality in K<sup>+</sup>-responsive chiral supramolecular hydrogels. Combined VCD and induced circular dichroism measurements confirmed that K<sup>+</sup>-triggered self-assembly enables long-range chirality t... |
41744337 | Coordination preference of pyridine-based ligands on Ag(111). | We systematically investigate the coordination preference of three pyridine-based organic ligands with linear, tripod and X-type skeletons and coordination sites on Ag(111) under different stoichiometric ratios. Distinct coordination preferences and binding energies of the coordination phases are identified, contributi... |
41738883 | Amorphization and defect engineering of Nb<sub>2</sub>O<sub>5</sub> within a graphitic nanocage array for catalytic polysulfide conversion in lithium-sulfur batteries. | Lithium-sulfur batteries (LSBs) are limited by lithium polysulfide (LiPS) shuttling and sluggish redox kinetics. To address this challenge, we design an amorphous, oxygen-deficient Nb<sub>2</sub>O<sub>5</sub> embedded in a mesoporous graphitic framework (Nb<sub>2</sub>O<sub>5</sub>@MGF) as a multifunctional interlayer ... |
41738832 | Upcycling waste plastic and spent batteries into hierarchical Co/carbon nanocomposites for high-performance electromagnetic wave absorption. | Here we upcycle waste polyethylene terephthalate (PET) plastics and spent LiCoO<sub>2</sub> batteries to synthesize hierarchical Co/C nanocomposites. Recovered terephthalic acid (R-TPA) and cobalt ions are used to fabricate a Co-based metal organic framework (Co-MOF) precursor, which is subsequently co-pyrolyzed with R... |
41728633 | A novel ratiometric electrochemical aptasensor based on β-cyclodextrinylated graphene and Fc/β-CD host-guest recognition for ultrasensitive detection of zearalenone. | Zearalenone (ZEN) is a carcinogenic mycotoxin commonly found in grains, cereals, and dairy products, posing cancer risks to humans and animals. Chronic high-dose ZEN exposure can cause liver disease, immunosuppression, kidney damage, and tumorigenesis. Sensitive and efficient ZEN detection is therefore essential for pr... |
41719316 | UiO-66-NH<sub>2</sub>@benzotrithiophene-based COF composites with core-shell structure for effective adsorption of dyes. | The treatment of wastewater containing organic dyes is an urgent environmental challenge, necessitating the development of advanced functional adsorbents. In this study, three covalent organic frameworks (COFs) with tailored pore sizes were synthesized from benzotrithiophene tricarboxaldehyde and different diamine link... |
41697034 | Light metal pyrazolates excel in carbon dioxide uptake. | The development of new carbon (CO<sub>2</sub>) capture materials has emerged as a top-priority transdisciplinary research field. Ideally, CO<sub>2</sub> is not only captured and stored (CCS), but also transformed into more valuable organic compounds, because CO<sub>2</sub> itself is a cheap, abundant, non-flammable gas... |
41661052 | Syrian hamster is a valuable animal model for evaluating the transmissibility of emerging influenza viruses. | Multiple influenza virus subtypes actively circulate in nature, and assessing their transmissibility provides crucial information for predicting their pandemic potential and for pandemic preparedness. Here, we evaluated the receptor-binding preferences, replication, and transmission of five different influenza viruses ... |
42006357 | Flexible polymeric materials and wearable biosensors for smart diabetes mellitus diagnostics and monitoring. | Diabetes mellitus remains a major global health challenge that requires frequent and accurate glucose monitoring. Conventional finger-prick methods are invasive and often lead to poor patient compliance. In response, flexible and wearable biosensors have emerged as promising platforms for continuous and non-invasive gl... |
41971686 | Composition-Encoded Control of Amphiphilicity and Nanoscale Rigidity in Poly(isobutyl cyanoacrylate)/Poly(butylene oxide)-<i>stat</i>-polyglycidol Nanospheres and Nanoellipsoids. | Tuning the interfacial hydrophobicity and morphology of polymeric nanomaterials remains a central challenge for controlling their structural, mechanical, and biological properties. Here, we introduce poly-(isobutyl cyanoacrylate)/(poly-(butylene oxide)-<i>stat</i>-polyglycidol) (PIBCA/(PBO-<i>stat</i>-PG)) nanospheres ... |
41958540 | Discrimination of Hexane Isomers by Temperature Swing Adsorption in a Rigid Aluminum Metal-Organic Framework. | The efficient separation of alkane isomers with similar physicochemical properties remains a persistent challenge for the petrochemical industry. Adsorptive separation using metal-organic frameworks (MOFs) offers an energy-efficient alternative to conventional distillation. Herein, we report temperature swing discrimin... |
41958539 | A Structurally Dynamic Pathogen-Mimicking Biomaterial Is an Efficient Activator of Dendritic Cells. | Structural dynamism confers intriguing applications to biocompatible materials. Here, we present a protein-based, self-organizing microscale material designed to mimic pathogen-like features. In this formulation, the building block proteins shift their organization through monomeric, microscale, or oligomeric nanoscale... |
41940347 | CGM23 corresponds to a pan-coronavirus lipopeptide inhibitor potently inhibiting virion fusion. | We developed a pan-coronavirus lipopeptide fusion inhibitor, CGM23, which binds to the highly conserved spike heptad repeat-1 domain, thus interrupting the formation of the six-helix bundle required for membrane fusion. <i>In vitro</i>, CGM23 potently inhibited infection by all human coronaviruses tested, including SAR... |
41940348 | Targeting the lethal weakness of SFTSV: Latest advances in antiviral strategies and immune prevention. | In recent years, severe fever with thrombocytopenia syndrome (SFTS), caused by the SFTS virus (SFTSV), has a fatality rate ranging from 12% to 50%, but there are currently no approved therapies to effectively treat the infection. Host cell receptors CCR2 and LRP1 have been identified as key entry points for viral invas... |
41940032 | Redox signaling in chronic airway diseases: pathogenic mechanisms and therapeutic implications. | Chronic airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and bronchiectasis, impose a significant global health burden. A central unifying feature of these diseases is redox imbalance, which is characterized by an excess of reactive oxygen and nitrogen species (ROS/RNS) that overwhelms t... |
41924150 | Twisted-Nematic Liquid Crystal-Infiltrated Bilayer Metasurface for Circular-Polarization LCoS Devices. | Optical chirality underpins applications ranging from molecular identification to facial recognition. Metasurfaces have recently emerged as a versatile platform for compact chiral photonic devices. Here, we demonstrate electrically tunable circular dichroism (CD) at telecommunication wavelengths using a bilayer metasur... |
41908442 | Enhancing the Optical Properties of MAPbI<sub>3</sub> Perovskites Passivated with Coordinating and Hydrogen Bond Donor Ligands. | <b>MAPbI</b> <sub><b>3</b></sub> (MA; methylammonium) perovskite films were treated with both fluorinated (trifluoroacetamidine, TFA, and trifluoroacetamide, TFAM) and nonfluorinated (oxamide, Oxa) hydrogen bond donors as additives. The corresponding films named <b>Oxa-MAPbI</b> <sub><b>3</b></sub> , <b>TFA-MAPbI</b> <... |
41908380 | Argon Microwave Plasma Processed Electrodeposited FeCo Catalysts on Ti Paper as an Anode Porous Transport Layer (PTL) for Cathode-Dry Anion Exchange Membrane Water Electrolysis (AEMWE). | ED-FeCo/TP is synthesized by the electrochemical deposition of FeCo on titanium fiber paper (TP) as the catalyst for the oxygen evolution reaction (OER) in cathode-dry operation anion exchange membrane water electrolysis (AEMWE). With 15 s Ar microwave plasma (ArMP) treatment, the catalytic performance is enhanced. The... |
41907166 | How are kefir microbial communities and product characteristics maintained in industrial production? | Kefir, a millennia-old symbiotic fermented dairy product, has emerged as a focal point of research in the global functional foods sector owing to its distinctive organoleptic properties and extensive health-promoting effects. Kefir grains, serving as the natural starter culture for traditional kefir, constitute a compl... |
41902251 | Pathogenicity, Resistance Genes and Integrated Management Strategies of <i>Potato Virus Y</i> in Potato. | <i>Potato virus Y</i> (PVY), widely regarded as one of the world's most important plant viruses, seriously threatens global potato production and food security. PVY deploys its proteins to interact with key host factors, thereby enabling viral replication, accumulation, and systemic infection. PVY also exhibits high ge... |
41901812 | Polymer Matrices for Reversible Thermogelling Hydrogels: Principles, Fabrication, and Drug Delivery Prospects. | This review presents a comprehensive analysis of modern thermosensitive polymer systems for in situ systems (ISSs) which are used for targeted drug delivery in situ. The main classes of polymers used to create "smart" hydrogels that undergo a "sol-gel" phase transition in response to a temperature stimulus in the physi... |
41901301 | Pharmacokinetic Modeling of the "Nose-to-Brain" Pathway as Demonstrated by Intranasal Administration of Cannabidiol-Loaded Nanoparticles. | <b>Background/Objectives</b>: Cannabidiol is a non-psychoactive substance that possesses properties suitable for the treatment of several disorders related to the central nervous system. However, successful administration of cannabidiol remains challenging due to low and variable bioavailability and potential adverse e... |
41901302 | Anti-Inflammatory Activity of Cyclic Imide Derivatives. | Imide derivatives constitute an interesting group of compounds exhibiting broad biological activity. Structures containing the imide moiety [-CO-N(R)-CO-] occur in both natural and synthetic compounds. Several drugs containing an imide moiety are in therapeutic use. In this review, we present the structures and describ... |
41901300 | Comprehensive In Silico Investigation of L-Glutamine Transporters and Metabolism in Glioblastoma. | <b>Background/Objectives:</b> Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and remains associated with poor prognosis despite multimodal therapy. Metabolic reprogramming, particularly increased dependence on glutamine, supports GBM bioenergetic, biosynthetic, and redox demands. This study aim... |
41901299 | Biomarker-Guided Drug Delivery Systems and Oral Bioavailability Enhancement. | Biomarker-based guided delivery of drugs is an emerging paradigm of precision medicine in which targeted therapeutic intervention is administered on the basis of certain biological markers in order to achieve maximal dosing, targeting, and time optimization. By utilizing quantifiable physiological or molecular signatur... |
41900836 | Comparative Biofunctionality Assessment of Lignin and Lignin/Chitosan Nanoparticles: Impact of Chitosan Co-Assembly on Cytotoxicity, Cytocompatibility, Radical-Scavenging Activity, and Antimicrobial Performance. | <b>Background/Objectives:</b> The aim of the present study was to conduct a systematic in vitro assessment of the biofunctionalities of newly synthesized lignin (LNPs) and lignin-chitosan nanoparticles (LCNPs) via a comparative in vitro estimation of their cytotoxicity, cytocompatability potential, radical-scavenging a... |
41900833 | Development and Characterization of Heparin-Pullulan Liposomal Nano-Gel for Enhanced Silymarin Delivery in Dementia Therapy: In Vivo Evaluation in Albino Mice. | <b>Background/Objectives</b>: Dementia remains one of the major global health challenges of the modern era. Researchers worldwide continue to seek effective therapeutic strategies to combat this neurodegenerative condition. Silymarin is a natural compound with strong neuroprotective and antioxidant properties that hold... |
41900829 | Self-Assembled Gefitinib Nanosuspension Prepared via Hummer Acoustic Resonance Technology: Enhanced Dissolution, In Vitro Anticancer Activity and Long-Term Stability. | <b>Background</b>: Gefitinib (Gef) is a first-line epidermal growth factor receptor (EGFR) inhibitor for NSCLC, but its clinical application is limited by poor aqueous solubility and low oral bioavailability. <b>Methods</b>: A self-assembled gefitinib nanosuspension (GG-NS) incorporating genistein (Gen) was rapidly dev... |
41900041 | Applications of Carbon Dots and Graphene Quantum Dots in Treatment of Diabetes. | Carbon nanoparticles (CNPs) are increasingly being considered for medical applications. The objective of this article is to determine which anti-diabetic drugs and compounds have been enhanced by CNPs, and which CNP scaffolds were found to be successful. The anti-diabetic drugs administered loaded on CNPs include insul... |
41900038 | Comparison of Chlorophyll and Bacteriochlorophyll Ultrafast Transient Absorption Spectra and Kinetics. | Oxygenic and anoxygenic photosynthesis are initiated through the absorption of light by chlorophyll and bacteriochlorophyll photosynthetic pigments, respectively, which function as light-harvesting (antenna) and redox pigments on the photosynthetic membrane that trap and convert the absorbed optical energy into chemica... |
41900035 | Synthesis, Physical and Ion-Conducting Properties of 1,2,3-Triazolium Ionic Liquids. | 1,4-Disubstituted 1,2,3-triazoles are readily obtained by copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC)-the most widespread illustration of click chemistry to date. 1,2,3-Triazoles form a vast and easily accessible library of precursors for synthesizing 1,2,3-triazolium ionic liquids (TILs). A seri... |
41900043 | Nitroxide-Based Contrast Agents for MRI Cancer Diagnostics: Progress, Limitations, and Perspectives. | Magnetic resonance imaging (MRI) is one of the most powerful non-invasive methods for cancer diagnostics. To enhance image contrast and, therefore, diagnostic accuracy, contrast agents (CAs) are widely used in clinics. For decades, the clinical standard has been metal-based CAs, primarily gadolinium- and manganese-base... |
41900033 | Synthesis and Intramolecular Charge Transfer Studies on <i>meso</i>-Tetracyanobutadine-Functionalized Diphenylporphyrin Complexes Incorporating Copper and Nickel Metals. | This study presents the synthesis and electrochemical characterization of <i>meso</i>-tetracyanobutadiene (TCBD)-functionalized diphenylporphyrin (DPP) complexes incorporating copper (Cu) and nickel (Ni) metals. These push-pull metallo diphenylporphyrin-TCBD complexes were synthesized via a [2 + 2] cycloaddition-retroe... |
41900042 | Research on the Current Development Status of Redox Flow Batteries. | In recent years, flow batteries have emerged as a crucial technological solution for large-scale energy storage, leveraging their unique power-capacity decoupling characteristics and long cycle life to demonstrate significant potential in applications such as renewable energy integration and grid frequency regulation. ... |
41900029 | A Comparative Study of Choline Chloride Deep Eutectic Electrolytes: Towards Sustainable Supercapacitors. | Over the past few decades, ionic liquids (ILs) have gained attention as electrolytes, although concerns about their environmental persistence and toxicity challenge their status as green solvents. In this framework, choline chloride (ChCl) offers a more sustainable alternative due to its low toxicity, biodegradability,... |
41900030 | Electrochemical Sensing of Doxorubicin in Breast Cancer Cells Based on Membrane-Permeation Strategy. | Monitoring the concentration of doxorubicin (DOX) was critical for tumor treatment, but existing methods failed to cross cell membrane. Here, an electrochemical platform for intracellular DOX detection in MCF-7 cells based on membrane-permeation strategy was developed. A modified gold electrode was prepared via electro... |
41899731 | Competitive Anxiety as a Predictor of the Occurrence, Quantity, and Severity of Injuries in Young Cuban Athletes. | Previous studies suggest that elevated competitive anxiety may increase the likelihood of injury. The present research aims to examine the role of competitive anxiety as a predictor of injury occurrence, frequency, and severity. A cross-sectional, correlational design was conducted with 131 athletes (mean age = 16.49 y... |
41898968 | Mechanisms Responsible for Larval Diapause in <i>Anastatus japonicus</i> Ashmead, Shown by Integrated Transcriptomic and Proteomic Analyses. | Diapause enables insect survival in unfavorable environments. The parasitic wasp <i>A. japonicus</i>, a natural enemy of several fruit-tree pests, undergoes larval diapause. Previous work has shown that larval diapause in <i>A. japonicus</i> can be induced by medium temperatures in combination with short-day photoperio... |
41898448 | Stalling the Enemy: Targeting Nsp13 for Next-Generation SARS-CoV-2 Antivirals. | The SARS-CoV-2 public health challenges have highlighted the urgent need for coronavirus-targeting life-saving therapeutics. Given the emergence of drug-resistant strains, the development of antivirals against viral proteins beyond the commonly targeted main protease or RNA-dependent RNA polymerase is critical. The SAR... |
41898450 | Simultaneous Multi-Ion Heavy Metal Sensing Using Pulse and Stripping Voltammetry at Functionalized Nanomaterial-Modified Glassy Carbon Electrodes. | Glassy carbon electrodes (GCEs) have gained increased attention for the sensitive electrochemical detection of heavy metals due to their excellent chemical stability, wide potential window, and good electrical conductivity. These characteristics make GCEs an effective platform for sensor development. In particular, nan... |
41898445 | Anabolic-Androgenic Steroids Revisited: Structural Biology, Receptor Signaling, and Mechanisms of Anabolic-Androgenic Dissociation. | Steroid hormones exert diverse and tissue-specific biological effects despite sharing a conserved tetracyclic scaffold. Among these, anabolic-androgenic steroids (AAS) present a longstanding paradox: structurally related compounds can elicit markedly different anabolic, androgenic, and cardiovascular outcomes. This nar... |
41898446 | Rational Design of Mn-APTES/1-Methylimidazole Nanozymes: Enhanced Laccase-like Activity at Near-Neutral pH for Environmental Remediation. | Natural laccases are a widely reported option for pollutant degradation; however, their widespread application is severely restricted by high production costs, limited storage stability, and rapid inactivation at the neutral pH typical of wastewater treatment plants. To overcome these limitations, we rationally designe... |
41898443 | Recent Advances in Aptamer-Based Applications in Cardiology. | Aptamers, short single-stranded DNA or RNA oligonucleotides, are emerging as transformative tools in cardiology for the diagnosis, treatment, and theranostics of cardiovascular diseases (CVDs). This review highlights their dual utility. In diagnostics, aptamers enable the construction of highly sensitive biosensors for... |
41898426 | Unlocking the Potential Use of Berry Anthocyanins as Pharmaceutical Excipients and Nanocarriers: Evidence from the Last Decades. | Secondary metabolites, particularly natural phenolic compounds, have been a target of many studies and are a hot issue in the medical and scientific communities, due to their diverse biological activities, including antioxidant, anti-inflammatory, and antimicrobial effects. This bioactive potential has raised the prosp... |
41898427 | Strategies for Optimizing the Yield and Function of Recombinant Collagen in Different Expression Systems: A Review. | Collagen is the most abundant structural and functional protein in humans and other vertebrates. It possesses remarkable biological functions and is widely used in food, cosmetics, and healthcare. Currently, mainstream animal-derived collagen materials carry risks such as viral transmission and allergic reactions. Howe... |
41897719 | Native and Freeze-Dried Bacterial Nanocellulose as Fat Replacers in Low-Fat Meat Emulsions: A Comparative Study of Techno-Functional Performance. | Bacterial nanocellulose (BNC) is gaining interest in multiple industrial applications. BNC dehydration would improve its industrialization while affecting its techno-functional properties (water binding or gelling capacity). This work analyses this aspect in a representative food system where these are fundamental prop... |
41897717 | Facile Fabrication of Starch-Zein Core-Shell Microparticles by Antisolvent Precipitation for Reducing Starch Digestibility. | This study aimed to slow down starch digestion by encapsulating the starch granule within a firm zein shell via solvent-exchange-induced zein deposition. The zein shell adhered tightly to the granule surface and the shell thickness increased with increasing zein concentration. The average shell thickness of micropartic... |
41897500 | A Targeted Metabolomic Assessment of Oral Glutathione Bioavailability and Safety in Humans: A Randomized Crossover Clinical Trial. | Glutathione (GSH), often referred to as the "master antioxidant," plays a vital role in protecting cells against oxidative stress. This human pilot study aimed to evaluate the oral absorption and safety profile of a novel formulation of micellar glutathione (LipoMicel<sup>®</sup>, LMG) compared with two commonly used d... |
41897499 | Copper Dyshomeostasis, Redox Buffering and Immune Aging Converge on Cuproptosis in Age-Related Diseases. | Cuproptosis is a copper-dependent form of regulated cell death that is triggered when intracellular copper handling is perturbed and mitochondrial metabolism becomes the primary site of damage. Aging provides a biological context for this process because copper trafficking shifts, mitochondrial quality control and prot... |
41893561 | Report from the 31st Meeting on Toxinology, "Toxins: Playing with and Fighting Them!", Organized by the French Society for Toxinology on 1-2 December 2025. | The French Society for Toxinology (SFET) held its 31st annual meeting (RT31) on 1-2 December 2025 at Hôtel Le Saint Paul in Nice, France, on the famous French Riviera. The meeting, which gathered 75 participants from around the world, was organised there for the second consecutive year, while previous editions were all... |
41892550 | Marine Algae Hydrogels as Emerging Biomaterials for Medicine. | Marine algae, microalgae, and Cyanophyceae emerge as sustainable and versatile sources of biomacromolecules for the fabrication of hydrogels with broad biomedical potential. Their phycocolloids, such as alginate, agar, carrageenan, ulvan, and extracellular polysaccharides (EPS), exhibit intrinsic biocompatibility, tuna... |
41892292 | Lamin A/C as a Molecular Link Between Nuclear Organization, Chromatin Dynamics, and Tumor Progression. | Lamin A/C is emerging as a promising candidate regulator at the intersection of nuclear mechanics, chromatin organization, and gene regulation, linking structure and regulation, mechanics and epigenetics, constraint and plasticity. Lamin A/C was previously considered a static structural scaffold; however, it is now rec... |
41890911 | Persistent organic pollutants and prostate cancer: multiple mechanisms and comprehensive control strategies. | Persistent organic pollutants (POPs) are a class of chemical substances with environmental persistence, bioaccumulation, and high toxicity, which are widely present in the environment and food chains. Prostate cancer (PCa) is a highly prevalent malignant tumor in the male reproductive system, and the association betwee... |
41890758 | Nrf2 as a redox checkpoint in autoimmune joint inflammation: microenvironmental redox control across the arthritis spectrum. | Arthritis comprises a spectrum of immune-mediated joint disorders, with rheumatoid arthritis (RA) representing prototypic autoimmunity and psoriatic arthritis (PsA) and ankylosing spondylitis (AS) spanning an autoinflammation-autoimmunity continuum. Across this spectrum, oxidative stress and inflammatory signaling rein... |
41890581 | Discovery of novel repurposed anthelminthics against <i>Trichinella spiralis</i> and albendazole-resistant nematodes through metabolomics-guided virtual screening. | <i>Trichinella spiralis</i> is a parasitic nematode that causes trichinellosis, leading to weakness, muscle pain, facial edema, and potentially death<i>.</i> Albendazole (ABZ) is the current drug of choice; however, resistance has been increasingly reported, highlighting the urgent need for novel therapeutics. Developi... |
41890296 | <i>Bacillus subtilis</i> 8-32 enhances tomato growth and reshapes rhizosphere microbial communities: insights into plant-microbe interactions. | <h4>Introduction</h4>Plant growth-promoting rhizobacteria (PGPR) are crucial for sustainable agriculture, but their efficacy depends heavily on their colonization capacity within the rhizosphere and their interactions with native microbial communities. In previous studies, <i>Bacillus subtilis</i> strain 8-32 was scree... |
41890287 | Genotype-flexible plant genetic transformation: advances and prospects. | Genetic transformation of elite crop varieties remains limited by genotype-specific recalcitrance and dependence on tissue culture. This review provides a comprehensive analysis of current transformation platforms and emerging strategies to overcome these bottlenecks. We examine traditional <i>Agrobacterium</i>-mediate... |
41890168 | Features and mechanism of localized enzyme-assisted self-assembly of peptides from unilamellar vesicles. | Localized enzyme-assisted self-assembly (LEASA) has emerged as a powerful tool to generate peptide nanofibers from and within bacteria or cancer cell lines. This approach has led to promising developments in medical imaging, antimicrobial treatments and cancer therapies. Despite these achievements, the features of self... |
41889646 | Advances in anti-dengue virus properties of Traditional Chinese Medicines. | Dengue fever is an acute mosquito-borne disease caused by the dengue virus (DENV). Based on antigenic variations in the envelope (E) protein, DENV is classified into four serotypes (DENV-1 to DENV-4), with DENV-2 being most frequently associated with severe disease. Given its high transmissibility, broad geographic dis... |
41873998 | Clues to Long COVID Linked to Virulence and Infectivity Found in Shell Proteins. | Clinical, experimental, and computational evidence of COVID-19 virulence and infectivity has been linked to SARS-CoV-2 shell disorder. A strong link was first discovered using an AI disorder-predicting tool, which detected an unusually hard (low disorder) outer shell among all SARS-CoV-2-related viruses but not in the ... |
41871269 | Temporal Dynamics of Antidepressant Response Following Brexanolone Treatment in Postpartum Depression. | <b>Objective:</b> Major depressive disorder with peripartum onset (also known as postpartum depression [PPD]) (<i>DSM-5</i>) is a debilitating condition that can be characterized by difficulty transitioning out of a negative affective state. Given the rapid clinical response typically observed with brexanolone, the tre... |
41864151 | PEG chains modulate electrostatic interactions between PAMAM and articular cartilage. | Osteoarthritis is a debilitating disease of synovial joints affecting millions of people worldwide. Despite this, there are currently no disease modifying osteoarthritis drugs (DMOADs), mainly due to poor retention within the joint space. Previously, our group has shown that partially PEGylated cationic poly(amido amin... |
41855831 | Design and synthesis of fluorescent calix[4]arene-1,8-Naphthalimide derivatives: Transparent biofilms, antioxidant and antimicrobial properties, and real-samples applications. | Recent advances in materials science have underscored the role of supramolecular architectures in antimicrobial system design. Calix[4]arene-based systems have gained attention due to their structural versatility, fluorescence, and applicability in antimicrobial and food-packaging applications. Here, fluorescent calix[... |
41853579 | Delicate molecular design, self-assembly and functional applications of chiral cyclophanes. | Chiral cyclophanes represent a unique supramolecular architecture that integrates chiral cavities with luminescent properties, enabled by their precisely controlled interchromophoric orientation, distance, and asymmetry. These features confer exceptional chiral recognition capabilities and distinctive chiroptical behav... |
41849850 | Preparation and modification of Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@KOH&CD-OOR and its application to the detection of polycyclic aromatic hydrocarbons (PAHs) in food samples. | A green strategy was developed to modify cyclodextrin-based metal-organic frameworks (CD-MOFs) for fabricating magnetic solid-phase extraction (MSPE) adsorbents targeting polycyclic aromatic hydrocarbons (PAHs). β-cyclodextrin-based MOFs (KOH&β-CD) were synthesized and functionalized with four edible organic compounds ... |
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