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41847305 | Exploring Chinese Herbal Medicines for Acute Kidney Injury: Pharmacological Mechanisms and Clinical Potential. | <h4>Background</h4>Acute kidney injury (AKI) is a serious clinical condition marked by a rapid decline in renal function, leading to high morbidity, mortality, and healthcare burden. Despite advances in supportive care, effective pharmacologic therapies remain lacking, prompting interest in alternative approaches, incl... |
41847094 | Nanoparticles as a Promising Approach for Improving Skin Anti-Aging Activity. | The aging of skin is a multifaceted process influenced by internal factors and external influences. These factors contribute to the breakdown of skin structure, diminished skin resilience, and observable indications of aging. Conventional topical formulations often fail to deliver active chemicals adequately due to the... |
41837596 | Insights into the Recent Breakthroughs in Nanotechnological Outlook of Pentacyclic Triterpenoids: An Updated Approach. | Pentacyclic triterpenes have attracted significant scientific interest due to their notable biological activities against inflammation, cancer, liver diseases, oxidative stress, and bacterial infections. They are commonly found in fruits and vegetables and are marketed globally as nutritional supplements. Examples of p... |
41832830 | Dual-function photoinitiator-metal organic frameworks as a modular platform for tuneable composites. | Advanced functional materials based on metal-organic frameworks (MOFs) are limited by poor processability and weak compatibility with photopolymers. Although photopolymerization enables precise shaping, conventional small-molecule photoinitiators (PIs) can leach, causing cytotoxicity and yielding composites with PI mig... |
41830853 | A polyvinyl alcohol-gelatin composite hydrogel dressing for accelerated wound healing under electrical stimulation. | Searching for more effective and safer approaches to promote wound healing is a significant focus for addressing the limitations of hydrogel dressings. Herein, a composite conductive hydrogel was engineered to accelerate wound healing via inherent properties and combined with electrical stimulation (ES). The hydrogel w... |
41825845 | A NIR-Ⅱ fluorescent probe for real-time visualization and early assessment of responses to CDK4/6 inhibitors in breast cancer. | The evaluation of therapeutic response to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors in hormone receptor-positive (HR+), HER2-negative (HER2-) breast cancer currently relies on anatomical imaging, which suffers from significant delays. To enable early and direct visualization of drug activity, we developed a near-... |
41822912 | Advances in Surface Biofunctionalization and Intelligent Monitoring of Vascular Scaffolds. | Vascular scaffolds are fundamental devices in treating vascular occlusions, aneurysms, and hemodialysis access. However, their long-term efficacy is often compromised by 2 major pathophysiological responses: acute thrombosis and intimal hyperplasia, underscoring the need for effective antithrombotic treatment and inten... |
41822773 | High-performance polyimine xerogels: a lightweight and recyclable solution for high-temperature oil adsorption. | The remediation of viscous oil spills and organic contaminants in harsh environments requires sorbents that possess not only adsorption capability but also exceptional thermal and chemical stability. Herein, we report the facile synthesis of a novel class of fluorinated copolyimine xerogels (XG-CoPI) following the solv... |
41822204 | A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair <i>via</i> ROS scavenging, calcium influx inhibition, and macrophage polarization. | Spinal cord injury (SCI) is a severe type of central nervous system trauma. It not only causes the loss of sensory and motor function but also triggers a series of secondary injuries, especially oxidative stress and inflammation. Current therapeutic methods fail to effectively address the multi-pathological cascade rea... |
41814638 | Supramolecular Biopolymer Composed of a Doubly (His)<sub>6</sub>-Tagged Tandem Z-Domain Conjugated by Zn<sup>2<b>+</b></sup> Ions. | Synthetic two-dimensional (2D) protein assemblies were engineered using tandem Z-domains derived from the bacterial Protein A. Assembly was induced by introducing hexa-histidine tags to both the N- and C-termini of the tandem Z-domain ((His)<sub>6</sub>-(Z)<sub>2</sub>-(His)<sub>6</sub>) and adding equimolar Zn<sup>2+<... |
41814427 | Proteomics and tracer metabolomics link GAPDH ISGylation to glycolytic control. | <h4>Background</h4>Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) is implicated in the regulation of central carbon metabolism, but conflicting findings across experimental systems limit mechanistic insight. Here, we apply a multi-omics approach in cells ectopically expressing the ISGylation machinery ind... |
41814375 | Development of VP30-targeted nanoparticles using DPS4 fusion peptides for the inhibition of Ebola virus. | Multiple outbreaks of Ebola virus in West Africa have posed significant threats to global public health owing to its high pathogenicity and fatality rates. Current treatments for Ebola Virus Disease are limited, underscoring the imperative for novel antiviral therapies. VP30, a critical RNA synthesis factor, interacts ... |
41814339 | Dissolvable silk microneedles delivering minocycline-loaded ZIF-8 nanoparticles for targeted modulation of sebocyte metabolism and improved acne therapy. | <h4>Background</h4>Acne Vulgaris (AV) lesions exhibit an acidic, sebum-rich, and inflammation-prone microenvironment in which conventional minocycline therapy is constrained by the stratum-corneum barrier and systemic exposure. Here, we present the fabrication and application of dissolvable silk fibroin microneedles en... |
41814299 | Self-disassembling diatomic nanocluster bomb unlock reciprocal synergistic multi-pathway cancer therapy. | The emerging chemodynamic therapy (CDT), which leverages tumour microenvironment (TME)-specific conversion of H₂O₂ into cytotoxic reactive oxygen species (ROS), suffers from limited efficacy due to low-level endogenous H₂O₂, inefficient ROS generation, and oxidative stress adaptation. Herein, we develop self-reporting ... |
41814281 | Hydrogel-extracellular vesicle engineering delivery system: a promising therapeutic strategy for wound healing. | Chronic refractory wounds, such as diabetic foot ulcers, present significant clinical challenges due to a dysregulated healing microenvironment. Extracellular vesicles (EVs) have emerged as promising therapeutic agents owing to their pro-angiogenic, anti-inflammatory, and regenerative properties. However, their clinica... |
41814125 | Supramolecular Solvent Extraction for Doping Control Analysis of Prohibited Substances in Horse Urine. | Despite the recent success in introducing supramolecular solvents (SUPRAS)-based extraction to drug analysis, its application and robustness in day-to-day regular urine testing have yet to be demonstrated. Moreover, the applicability of SUPRAS in equine doping control testing remains unexplored. In this work, we have s... |
41814044 | Fracture risk assessment in patients with ileal urinary diversion after radical cystectomy: a comprehensive evaluation integrating bone mineral density, trabecular bone score, and FRAX®. | We conducted a comprehensive fracture risk assessment in 112 men with urinary diversion (UD) after radical cystectomy, integrating bone mineral density (BMD), trabecular bone score (TBS), and FRAX®. A substantial proportion met the diagnostic criteria for osteoporosis or had lower TBS values. These findings support rou... |
41813892 | Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR. | Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors detect pathogen effectors and activate immunity<sup>1</sup>. Coiled-coil NLRs (CNLs) form resistosomes as Ca<sup>2+</sup>-permeable channels in the plasma membrane (PM)<sup>2-4</sup>. However, the mechanism by which resistosomes activate cell death rem... |
41813822 | Heterologous expression, structural analysis, and functional characterization of Ostrinia nubilalis pheromone-binding protein 2 (OnubPBP2). | The European corn borer (Ostrinia nubilalis) is a major lepidopteran pest, causing annual maize losses of 5.5-8.5 million tons worldwide. Successful mating relies on the male's ability to detect species-specific, hydrophobic sex pheromones released by females. Pheromone-binding proteins (PBPs), abundantly expressed in ... |
41813786 | Comparative performance evaluation of chemical coagulants in dairy wastewater treatment: a multi-criteria decision-making approach. | This study evaluates the performance of an Effluent Treatment Plant (ETP) at a dairy industry in Bangladesh and investigates the potential of physicochemical pretreatment methods using chemical coagulants. Influent and effluent samples were collected three times over three seasons and analyzed for key parameters, inclu... |
41813702 | 3D-printable phosphorescent woody materials. | The preparation of sustainable biophosphors exhibiting room-temperature phosphorescence (RTP) for additive manufacturing presents both significant scientific promise and substantial synthetic challenges. To address this technological gap, with this research, we engineer CX-Wood using rational molecular design by grafti... |
41813682 | Auto-crosslinking sporesilk fibers promote endospore and Cry toxin clustering. | Bacillus thuringiesis infects and kills insect larvae via its spores and associated entomotoxin-containing parasporal bodies (PSBs). We show that endospores and PSBs of B. thuringiensis Sv. Israëlensis are covered in a 'sporesilk' matrix that consist of 8 nm wide fibers with a double helical symmetry, formed by protofi... |
41813680 | Water-generated dangling linkers in a metal-organic framework. | Metal-Organic Frameworks (MOFs) have attracted widespread attention for their applications in water-related contexts. A comprehensive understanding of the molecular-level interactions between water and MOFs is crucial for guiding molecular design and optimizing water-related applications. Water can act as a passive gue... |
41813677 | Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates. | Covalent transformations in biology follow defined temporal sequences that regulate processes such as acylation and phosphorylation, yet achieving comparable temporal control in synthetic systems remains challenging. Here, we report an abiotic aqueous reaction network in which aminoacyl phosphate esters bearing alkyne ... |
41813153 | Cyclopeptide-Based Fluorescent Conjugates for Monitoring Prefibrillar Aβ Nanostructures. | Amyloid-β (Aβ1-42) prefibrillar aggregates are considered the most neurotoxic amyloid species, yet their transient and heterogeneous nature makes selective detection challenging. Many fluorescent probes also fail to discriminate Aβ from homologous peptides such as IAPP, leading to poor specificity. We report a peptide-... |
41812183 | Self-Assembly of Single-Crystalline Nanomaterials for Integrated Electronics and Photonics. | The scalable integration of single-crystalline nanomaterials remains a critical challenge in modern materials science, involving precise control of crystal nucleation, growth, and long-range ordered assembly throughout material processing. This Review highlights emerging strategies for inducing ordered nanomaterial ass... |
41812070 | Integrating Sulfate with Crown Ether To Construct Supramolecular Radium Traps in an Anionic Zirconium Metal-Organic Framework. | Sequestration of radiotoxic <sup>226</sup>Ra<sup>2+</sup> is challenged by its complex coordination chemistry, which requires a precise molecular recognition strategy. Here, we report a supramolecular trap engineered within a stable zirconium metal-organic framework (ZJU-X102-SO<sub>4</sub>) by integrating a size-selec... |
41812069 | Hexapodal Halogen-Bond Receptor for the Selective Liquid-Liquid Extraction of Iodide from Water. | The continuous exploration of halogen-bond (XB) donor architectures unlocks vast opportunities in supramolecular chemistry. In this contribution, we report a newly designed hexapodal Hex-XB receptor by incorporating six XB donor sites integrated into a benzene platform. Hex-XB revels high selectivity toward iodide (I<s... |
41812001 | Acute-on-chronic liver failure and immune dysregulation: Systemic inflammation and immunoparesis paradox. | Acute-on-chronic liver failure (ACLF) is a severe clinical syndrome characterized by abrupt hepatic decompensation and systemic inflammation in patients with underlying chronic liver disease, frequently progressing to multi-organ failure and high short-term mortality. Although ACLF is increasingly recognized as a disti... |
41811966 | Experimental insights into the azotosome hypothesis in Titan's lake fluids. | Since the discovery of hydrocarbon lakes and seas on Saturn's moon Titan, there has been much speculation on whether these could serve as suitable environments to host exotic life. A decade ago, molecular dynamic simulations suggested that amphiphilic cyanide species such as acrylonitrile could self-assemble in these c... |
41811958 | Integrated reiterative pipeline for rapid epitope-based pan-alphavirus vaccines. | The vast diversity of the virosphere underscores the need for rapid, adaptable vaccine development infrastructures. Arthropod-borne zoonotic alphaviruses, in particular, continue to pose substantial threats to human and animal health. We present a fast, multitarget vaccine design pipeline integrating machine learning-b... |
41811950 | Enhancing plant antiviral responses and productivity through the elimination of m<sup>5</sup>C methyltransferase. | RNA 5-methylcytosine (m<sup>5</sup>C) plays an undefined role in plant antiviral defense. Here, we reveal that the wheat methyltransferase NOP2/Sun RNA methyltransferase 2 (TaNSUN2) is an RNA m<sup>5</sup>C methyltransferase recruited by eukaryotic elongation factor 1-alpha (TaeEF1A) into Chinese wheat mosaic virus (CW... |
41811943 | A previously unrecognized class of fungal ice-nucleating proteins with bacterial ancestry. | Ice-nucleating proteins (INpros) catalyze ice formation at high subzero temperatures, with major biological and environmental implications. While bacterial INpros have been structurally characterized, their counterparts in other organisms have remained largely unknown. Here, we identify membrane-independent proteins in... |
41811942 | A persistent-range hydrogen-bonded gel polymer electrolyte enabling wide-temperature and recyclable lithium metal batteries. | Although energy density and cycling stability remain central to lithium metal battery (LMB) research, particularly in solid-state systems, two critical yet underappreciated challenges are wide-temperature operability and recyclability. These key parameters are fundamentally governed by electrolyte design. Here, we intr... |
41811937 | Leaky by Design: Unlocking Polymersome Permeability Using Moderately Hydrophobic Polymer Blocks. | Polymersome nanoreactors, vesicular assemblies formed from amphiphilic block copolymers, provide a versatile platform for compartmentalized catalysis and the construction of biomimetic systems. While extensive efforts have focused on the encapsulation of enzymes within such constructs, reports of vesicles displaying in... |
41811936 | Exploring potential phytocompounds from black cumin as drug molecules against SARS-CoV-2 infections through bioinformatics analysis. | SARS-CoV-2 was identified at the end of 2019 as the key cause of COVID-19, a global pandemic. As remedies, different vaccines as well as synthetic drugs have been recommended. However, the availability of natural drugs against SARS-CoV-2 infection is limited, although natural drugs are considered as less toxic than syn... |
41811876 | Dynamics of the formation of flat clathrin lattices in response to growth factor stimulus. | Clathrin assemblies on the cell membrane are critical for endocytosis and signal transduction in cells. Specifically, the Ω-shaped clathrin assembly functions as the coat of endocytic vesicles, while the flat clathrin assembly, also known as the flat clathrin lattice (FCL), serves as a signaling hub for various pathway... |
41811616 | Acriflavine-empowered IR780-PTX albumin nanoparticles for reinforced synergistic photochemotherapy. | Traditional chemotherapy and radiotherapy for glioma are challenging due to the hypoxia in tumor microenvironment and the inability of chemotherapeutic agents to enter into tumor cells. Phototherapy is a novel therapeutic approach against various tumors in recent years. When combined with chemotherapy, the antitumor ef... |
41811556 | Endophytic fungi of Aegle marmelos as a source of novel antibacterials and anti-SARS-CoV agents. | Drug resistance in microorganisms is a growing global threat, highlighting the urgent need for novel therapeutic agents. This study evaluates the antibacterial and anti-SARS-CoV potential of fungal endophytes isolated from A. marmelos. Among 16 endophytes screened, the ethyl acetate extract of the #3 AMLBF strain (Fusa... |
41811548 | Integrated Genome-wide Association and Single-cell Transcriptomic Analysis Identifies OAT as Therapeutic Targets for Periodontitis. | Periodontitis is a chronic inflammatory disease affecting tooth-supporting tissues. Beyond microbial dysbiosis, host metabolic regulation plays a critical role. This study identified ornithine aminotransferase (OAT), a mitochondrial enzyme in amino acid metabolism, as associated with altered fibroblast phenotypes and m... |
41811475 | A highly sensitive colorimetric platform based on tricoordinate metal MOFs nanoenzymes and smartphone RGB-assisted analysis for visualized detection of Salmonella typhimurium. | This study presents a signal-amplified detection platform integrating magnetic separation, PtAuRu@PCN-224 nano-enzyme catalysis magnification, and smartphone RGB analysis. The developed detection system has the following advantages: ultra-high sensitivity, the detection limit in ultraviolet-visible light mode is 1 CFU/... |
41811454 | Conserved use of tetraspanin CD9 as an entry receptor by rhabdoviruses spanning multiple genera. | Rhabdoviruses exhibit a broad host range, yet the cellular receptors underlying their cross-species tropism remain poorly defined. Here, we identified tetraspanin CD9 as a conserved functional entry receptor for diverse rhabdoviruses across genera, including viral hemorrhagic septicemia virus (VHSV) (<i>Novirhabdovirus... |
41811349 | Expanding the Coordination Chemistry of Decavanadate through π-Hole Interactions with Transition-Metal Cyclen Complexes: Electronic Features and Dye Adsorption. | The hybrid decavanadate with macrocycle cyclen (1,4,7,10-tetraazacyclododecane) complexes with the formula [Ni(cyclen)(H<sub>2</sub>O)<sub>2</sub>]<sub>2</sub>[H<sub>2</sub>V<sub>10</sub>O<sub>28</sub>]·2H<sub>2</sub>O (<b>1</b>) was prepared as an ionic pair, while [{Cu(cyclen)}<sub>2</sub>(H<sub>2</sub>V<sub>10</sub>... |
41811082 | Characterization of the cell division-associated peptidoglycan amidase AmiA of <i>Chlamydia trachomatis</i>. | <i>Chlamydia</i> is an obligate intracellular bacterium that differentiates between infectious, non-dividing EBs and non-infectious, dividing RBs. Pathogenic <i>Chlamydia</i> species are unusual in lacking a peptidoglycan sacculus, yet they do synthesize a transient and localized peptidoglycan structure at the divisome... |
41810974 | Ultra-Uniform Lithium-Ion Transport Enabled by Supramolecular Polymeric Networks as Artificial Solid Electrolyte Interphase Layers for Highly Stable Lithium-Ion Battery Anodes. | Polymer-based artificial solid electrolyte interphase (SEI) layers have emerged as a promising solution to address the inherent limitations of silicon-carbon nanocomposite (SCN) anodes. However, their practical implementation remains hindered by the inherent trade-off between achieving complete surface coverage and mai... |
41810867 | Predicting Fracture Risk After Non-Recent High Risk Fracture: Improving accuracy with simple modifiers to FRAX. | Prior fracture is among the strongest predictors of future osteoporotic fracture. However, the Fracture Risk Assessment Tool (FRAX®) incorporates it as a dichotomous variable, potentially obscuring important heterogeneity related to fracture site and multiplicity. Although recent (≤2-year) fractures are recognized as c... |
41810580 | Solvent-Controlled Construction of Charge-Transfer Solid-State Supramolecular Polymers and Their Application in Selective Pyridine Vapor Detection. | This study employs a solvent-directed strategy to construct organic charge-transfer (CT) supramolecular polymers in the solid states. By utilizing clamparene (CLP) and 4-nitrobenzonitrile (NBN) as building blocks, we achieved topologically controlled self-assembly in different solvents. Specifically, in acetonitrile (C... |
41810558 | Asymmetric Total Synthesis of (-)-Verrucarol. | We disclose a concise, asymmetric synthesis of (-)-verrucarol, the natural product precursor of bioactive trichothecene macrocycles including verrucarins A and J. Historically, enantioselective construction of the 6/6/5 (A/B/C) ring system of the 12,13-epoxytrichothec-9-ene (EPT) core of trichothecene natural products ... |
41810554 | Carbon Surface Curvature-Mediated Electronic Fingerprints for Nucleic Acid Base Identification: First-Principles Investigation of Voltage-Dependent Recognition on Carbon Nanomaterials via Nonequilibrium Green's Function. | Carbon-based nanodevices for bioactive molecular recognition are crucial for biochemical engineering and novel probe development. This is heavily dependent on the surface interaction between the carbon-based nanomaterials (CNMs) and bioactive molecules. However, CNMs with variable topological structures and curvatures ... |
41810535 | Transdermal Behavior and Molecular Dynamics Simulation of Chitosan-Cross-Linked <i>Sapindus</i> Extract Liposomes. | To enhance the skin permeability and retention of <i>Sapindus</i> saponins, cationic liposomes are fabricated via a thin-film dispersion method followed by electrostatic cross-linking with chitosan. The Franz diffusion cell method is used to evaluate the transdermal performance, while molecular dynamics (MD) simulation... |
41810478 | Uncompromised reinforcement: polysiloxane with 100% room-temperature self-healing and antifouling. | To resolve the "strengthening-self-healing" contradiction and antifouling requirements of self-healing polysiloxane materials, this study prepared a hydrogen-rich polysiloxane resin (SDC) containing dynamic imine bonds. By compositing low-content silane-homologous modified graphene oxide (s-GO) and a silver metal-organ... |
41808539 | Ammonia-Induced Metal-Organic Framework Membrane Pore Tuning for Hydrogen Separation. | Ammonia has attracted great attention as a key material for clean hydrogen production, such as the ammonia cracking process. Remaining trace ammonia in the purification step is considered a critical impurity due to its toxic and corrosive nature. Herein, we introduce ammonia as a tuning agent for MOF membranes to contr... |
41733984 | Strong viscoelastic glycerol solutions formed from phenylalanine-based amine oxide surfactants. | Forming giant aggregates with surfactants in nonaqueous solvents is typically challenging due to weak solvophobic interactions. In this study, a series of phenylalanine-based surfactants-alkyl phenylalanine amide oxides (Cn-Phe-AO, <i>n</i> = 12, 14, and 16)-were synthesized. These surfactants independently induced gel... |
41733589 | A supramolecular host with a cavitand core and four cholate side arms. | Copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) was employed to synthesize a new cavitand (1) having four cholate groups covalently connected to the cavitand core. CuAAC between a tetrapropargyl cavitand 2 and 3α-azido-cholic acid 3 led to the isolation of pure cavitand 1, which was fully characterized by the us... |
41725543 | Chiral borophosphate catalyzed asymmetric hydroamination of alkenes. | Chiral pyrrolidines are key motifs in natural products and pharmaceutically active intermediates. Herein, we report a metal-free enantioselective intramolecular hydroamination of alkenes catalyzed by a chiral borophosphate. This chiral frustrated Lewis pair (FLP)-type catalyst outperforms chiral phosphoric acid alone, ... |
42002875 | Acute-on-chronic liver failure: From definition to pathogenesis and therapy. | <h4>Abstract</h4>The concept of acute-on-chronic liver failure (ACLF) has been widely accepted around the world since it was proposed nearly 30 years ago, but there are still no universal criteria for the definition and diagnosis of ACLF worldwide. In recent years, the key clinical features for describing ACLF, such as... |
41939387 | Quantum Chemical Topology Analysis of Covalent Interactions in the Hydration of F<sup>-</sup> along with the Zinc Finger of NPL4 and Its Application to the Delimitation of QM/MM Boundaries. | The accurate modeling of metalloproteins remains a central challenge in computational chemistry, particularly when classical force fields fail to describe metal-ligand interactions with significant covalent character. Herein, we present a diagnostic methodology to delimit quantum mechanical regions in hybrid quantum me... |
41937934 | Convergent Synthesis of Tetradentate Aminopyridine C-H Oxidation Catalysts. | Controlling the oxidation of unactivated C-(sp<sup>3</sup>)-H bonds through supramolecular catalyst-substrate interactions has recently enabled site-selective transformations previously considered inaccessible. However, progress has been hampered by lengthy linear syntheses of supramolecular catalysts. Here we present ... |
41924167 | Ligand-Enabled Hydrohydrazidation of Alkynes Catalyzed by Unsymmetrical Gold(I)-Thiazol-2-ylidenes. | Acyl hydrazines represent a privileged class of amide derivatives in organic synthesis and drug discovery, however, methods for effecting site-selective hydrohydrazidation remain underdeveloped. Herein, we report highly selective Au(I)-NHC-catalyzed (NHC = N-heterocyclic carbene) addition of acyl hydrazines to alkynes ... |
41918991 | Stacking Effects on the Optoelectronic Properties of 2D Perylene-Zn-Porphyrin-Based COFs. | Crystalline porous materials, such as covalent organic frameworks (COFs), have emerged as promising candidates for photocatalytic and optoelectronic applications due to their tunable architecture and capacity to mitigate charge recombination. The incorporation of highly aromatic organic building blocks that promote sel... |
41909225 | Supramolecular self-assembly of EGCG-cysteine nanodrugs for ferroptosis and oxidative stress inhibition in chondrocytes to treat osteoarthritis. | Osteoarthritis (OA) is a common chronic degenerative joint disease that is characterized mainly by the destruction of articular cartilage, synovial inflammation and osteophyte formation, and seriously affects the quality of life of middle-aged and elderly individuals. Recent studies have shown that ferroptosis plays an... |
41908628 | Near-infrared (NIR)-responsive activation of Ru-benziphthalocyanine complexes <i>via</i> singlet-triplet transition. | Near-infrared (NIR) light-responsive molecules are important tools in life sciences due to high tissue transparency and low phototoxicity in this wavelength region. However, conventional compounds are generally activated <i>via</i> S<sub>0</sub>-S<sub>1</sub> transition, which requires relatively high-energy excitation... |
41908469 | Potassium <i>tert</i>-Butoxide-Mediated Isomerization of Alkenes: A Versatile Protocol for Miscellaneous Substrates. | The development of rapid and efficient routes to alkene derivatives remains a significant priority due to their broad utility as building blocks and valuable compounds. Herein, we report a simple, general, and highly efficient procedure for the (catalytic) isomerization of alkenes under mild conditions. This method is ... |
41907305 | Unleashing the power of DNA-encoded libraries for challenging targets in drug discovery. | DNA-encoded library (DEL) technology has emerged as a transformative platform in early-stage drug discovery, enabling the rapid and cost-effective exploration of ultra-large chemical spaces. However, identifying ligands for challenging targets characterized by featureless surfaces, high conformational plasticity, or sh... |
41901802 | Phytic Acid and Its Derivatives as Valuable Flame Retardants for Polymer Systems: Current State of the Art and Perspectives. | Phytic acid (myo-inositol hexakisphosphate) and its salts, including iron, aluminum, sodium, and lanthanum phytate, are perhaps the most recent discovery in the field of bio-sourced flame retardants. Phytic acid can be extracted from sustainable resources, such as beans, cereals, and oilseeds. Its high phosphorus conte... |
41901804 | Polyethylene Glycol Nanocolloids as Advanced Phase Change Materials for Sustainable Energy: Experimental Data on Viscosity, Density, and Isobaric Heat Capacity. | Polyethylene glycols (PEGs) are emerging as superior and accessible phase change materials and heat transfer fluids, offering improved thermal properties over conventional thermal oils to meet the demand for innovative, sustainable energy solutions. While general research on PEG performance is still scarce, this paper ... |
41901295 | Myricetin Nanofibers as Amorphous Delivery System. | <b>Background:</b> Myricetin (MYR) is a natural flavonol with antioxidant, neuroprotective, anti-inflammatory, antidiabetic, and cardioprotective activities. Still, its pharmaceutical use is limited by very low aqueous solubility (~16.6 µg/mL) and poor oral bioavailability (<10%). This study aimed to enhance the solubi... |
41900972 | Transcriptomic Profiling Identifies a Distinct Molecular Signature in OSMF-Derived Oral Squamous Cell Carcinoma. | <b>Background:</b> Oral Submucous Fibrosis (OSMF) is a significant global oral health problem, particularly prevalent in India, with a high risk of progression to Oral Squamous Cell Carcinoma (OSCC). This study investigates the molecular mechanisms involved in the transformation of OSMF to OSCC using transcriptomic pro... |
41900827 | Coumarin-Based Prodrugs: Therapeutic Promise or Still Confined to Preclinical Exploration? | Coumarin-based compounds are recognized for their chemical versatility and diverse biological activities, yet clinical applications remain largely confined to 4-hydroxycoumarin anticoagulants. To bridge this translational gap, coumarin scaffolds have been increasingly employed in prodrug design to enable controlled act... |
41900548 | Magnetic Nanostructures for the Removal of Emerging Organic and Inorganic Pollutants: An Overview of Applications in Contaminated Water. | Magnetic nanomaterials (MNMs) have been adopted as effective platforms for water remediation owing to their excellent surface-area-to-volume ratios, tunable surface chemistry, and magnetic separability. This review highlights the recent progress made in the synthesis, properties, and environmental applications in the r... |
41900541 | Evolution of High-Temperature Oxygen Clusters and Radical Release: A Molecular Dynamics Study in Pure Oxygen and Titanium Tetrachloride Oxidation Environments. | Despite decades of research into high-temperature oxidation kinetics, the atomic-scale origin of oxygen radical formation-a critical driver of the synthesis of functional oxide materials, oxidation corrosion of alloys, and combustion of fuels-remains elusive. Here, we unveil a previously unrecognized "oxygen clustering... |
41900025 | Synthetic Strategies and Biological Diversity of Biflavonoids: Current Status and Perspective. | Biflavonoids are natural or pseudo-natural polyphenolic compounds formed by linking two flavonoid monomers via different bonds. Their unique dimeric structure endows them with broad-spectrum biological activities, establishing them as a core focus in drug development. However, the extremely low abundance and high struc... |
41899494 | Biological Advances and Current Challenges for Pediatric Rhabdomyosarcoma. | Despite comprehensive and multi-modal therapy, outcomes for children and adolescents with rhabdomyosarcoma (RMS) have plateaued over the past four decades. This is not for a lack of progress in the basic and translational studies of RMS. Indeed, advances in animal models and/or patient tissue sample acquisition and ana... |
41899038 | From Biomaterial Innovation to Surgical Practice: A Systematic Review of RADA16 Self-Assembling Peptide Hydrogel in Otolaryngology and Head & Neck Surgery. | <b>Background</b>: Postoperative bleeding is a frequent complication in otolaryngology and head and neck surgery, often leading to readmissions and increased healthcare costs. <b>Objectives</b>: This systematic review evaluates the clinical efficacy, safety, and impact of RADA16, a synthetic self-assembling peptide hyd... |
41898394 | Synthesis of 2-Aryl-4-aminoquinazolines: Design, Molecular Docking, and In Vitro Assessment of Antibacterial and Cytotoxic Potential. | Antimicrobial resistance (AMR) remains a major threat to modern medicine, fueled by the excessive use of antibiotics and the spread of multidrug-resistant pathogens such as methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). In this study, we designed and synthesized a series of 2-aryl-4-aminoquinazoline derivat... |
41898398 | Drug Repurposing of Verapamil for H1N1 Influenza Virus Infection: A Multi-Target Strategy Revealed by Network Pharmacology and Experimental Validation. | Influenza A virus (IAV) infection constitutes a major public health threat. Severe influenza virus infection can induce intense inflammatory responses and lung injury, leading to serious clinical symptoms or even death. The utility of current anti-influenza drugs is often limited by side effects and the emergence of dr... |
41898392 | Computational Identification of Potential Novel Allosteric IHF Inhibitors Using QSAR Modeling to Inhibit Plasmid-Mediated Antibiotic Resistance. | The rapid spread of antibiotic resistance through plasmid-mediated conjugation remains a primary global health concern. Despite its critical role in horizontal gene transfer, no approved drugs currently target this process, leaving a critical therapeutic gap. Integration Host Factor (IHF), a DNA-binding protein essenti... |
41898400 | Addressing the Challenges of Solid-State Nanopores: Strategies for Performance Enhancement. | Solid-state nanopore sequencing, a key third-generation sequencing technology, offers considerable potential for genomics and diagnostics due to its long read lengths, real-time detection, and amplification-free operation. The technology identifies DNA sequences by measuring characteristic changes in ionic current as s... |
41898264 | The Current State of the Art in PAMAM and PLL Dendrimers, Boron Clusters, and Their Complexes for Biomedical Use. | Poly(amidoamine) (PAMAM) and poly-<i>L</i>-lysine (PLL) dendrimers have emerged as highly versatile macromolecular platforms with significant potential in biomedical applications, owing to their well-defined architecture, tunable surface chemistry, and capacity for multivalent functionalization. Their ability to carry ... |
41897693 | Conventional Chromatographic Techniques and Biosensors for Mercury Speciation in Seafood: A Systematic Review. | Mercury (Hg) is of significant concern due to its toxicity, which strongly depends on its chemical forms, and organic mercury compounds, particularly methylmercury (MeHg), are considered the most toxic species. Therefore, mercury speciation analysis is essential for accurate exposure and risk assessment. The primary di... |
41897346 | Licochalcone A as a Potential Anti-<i>Toxoplasma</i> Agent: A Target Identification and Pharmacokinetic Study. | Toxoplasmosis is a zoonotic disease with limited therapeutic options, which are further hampered by significant toxicity and suboptimal efficacy. Effective interventions for chronic infection remain insufficient, and thus, natural product-derived drug screening remains a key focus in anti-<i>Toxoplasma</i> research. Li... |
41897345 | Systemic Effects of Oral Antibiotics in Mice: A Combined Physiological and Molecular Approach. | This study investigates the systemic effects of amoxicillin and tetracycline on healthy Mus musculus (Swiss albino) mice, focusing on food intake, body weight, and hematological parameters. Over a 14-day oral treatment period, both antibiotics significantly reduced weight gain and food efficiency, with sex-specific var... |
41893509 | New Insights into the Relationship Between Microplastics and Diabetes from the Perspective of the Gut-Liver Axis and Macrophage Regulation. | Microplastics (MPs) are increasingly recognized as a global environmental threat. Emerging evidence suggests they may have metabolic consequences. In this review, we synthesize current findings from animal and in vitro studies to propose a mechanistic framework linking MP exposure to type 2 diabetes mellitus (T2DM). Th... |
41893508 | Machine Learning Prediction of Transthyretin Binding for Thyroid Hormone Transport Disruption for Chemical Risk Assessment. | Endocrine-Disrupting Chemicals (EDCs) disrupt thyroid hormone (TH) synthesis, transport, metabolism, and action, thereby perturbing systemic endocrine homeostasis. Transthyretin (TTR) is a key TH transport protein that regulates circulating hormone distribution and tissue availability, particularly during critical deve... |
41893335 | Integrative Transcriptome and Metabolome Analysis Reveals the Regulatory Networks and Key Biosynthetic Pathway Genes of Wild and Cultivated <i>Gentiana macrophylla</i> Pall. | <h4>Objectives</h4><i>Gentiana macrophylla</i> Pall. (Gentianaceae) is a medicinally important perennial herb. Iridoids are the main chemical constituents of <i>G. macrophylla.</i> The scarcity of the wild resource has led to increased attention to cultivated <i>G. macrophylla</i>. However, little is known about the me... |
41893286 | Modification of Polysulfone Substrate with GO-PAMAM Nanocomposite for Improved Desalination Performance. | Globally, freshwater scarcity is driving the urgent demand for advanced and new desalination technologies to overcome the shortage of clean water. Reverse osmosis (RO) membranes dominate seawater and brackish water treatment but are limited by the permeability-selectivity trade-off, fouling, and structural instability.... |
41893216 | Inorganic and <i>Erythroxylum coca</i> Leaf Extract-Mediated Synthesis of Gold Nanoparticles: A Comparative Study of Size, Surface Chemistry, and Colloidal Stability. | Gold nanoparticles (AuNPs) were synthesized via two complementary routes, an inorganic surfactant-mediated method and a plant-extract-assisted biosynthesis, to elucidate how synthesis pathways influence nanoparticle physicochemical properties. In the inorganic route, hexadecyltrimethylammonium bromide (CTAB)-stabilized... |
41893191 | Living Tissues by Design: The Rise of Hybrid Models in Biofabrication. | Current in vitro tissue models struggle to recapitulate the structural, vascular, and mechanical complexity of human tissues, limiting their physiological relevance for disease modelling and preclinical testing. Self-organising three-dimensional cultures such as spheroids and organoids capture key aspects of cellular o... |
41892963 | <i>Halamphora</i> sp. Reduces Inflammation in LPS-Stimulated Human Malignant Melanoma and Immortalized Keratinocytes Influencing TNF-<i>α</i> Release. | Malignant melanoma is skin cancer arising from genetically altered melanocytes. Recently, a complex relationship between melanoma and chronic inflammation has been highlighted, representing an excellent condition for tumor development. Microalgae have been shown to be a promising source of bioactive compounds for drug ... |
41892445 | Revitalizing Trimethoprim/Sulfamethoxazole via Nanotechnology for Improved Pharmacokinetics and Antibacterial Efficacy. | <b>Objective</b>: The therapeutic efficacy of the classic antibiotic combination trimethoprim/sulfamethoxazole (TMP/SMZ) is often limited by the significant pharmacokinetic mismatch. In this study, a polyethylene glycol-polylactic-co-glycolic acid (PEG-PLGA) nanodelivery system was employed to improve the pharmacokinet... |
41892441 | Probiotic and Postbiotic Interactions of <i>Lactobacillus</i> Strains with <i>Candida albicans</i>: Antifungal Effects Through Microbial Competition. | <b>Background:</b><i>Candida albicans</i> is the most clinically significant opportunistic fungal pathogen, and the growing resistance to conventional antifungals, particularly azoles and echinocandins, highlights the urgent need for alternative therapeutic strategies. Although lactic acid bacteria (LAB) have shown inh... |
41892287 | Role of Alternative Splicing and Polyadenylation in Regulation of Spleen Development. | Alternative splicing (AS) and alternative polyadenylation (APA), as post-transcriptional regulatory mechanisms, are involved in various biological processes through the generation of transcript variants. However, genome-wide studies of AS and APA during spleen development are scarce. This study aimed to characterize tr... |
41892046 | Effects of Sample Deposition Medium and Drying on Spectroscopic Quantification of Lipid Biomarkers in Respiratory Distress Syndrome. | Rapid point of care assessment of pulmonary surfactant composition by measuring the lecithin/sphingomyelin (L/S) ratio could improve management of patients with neonatal respiratory distress syndrome (nRDS). Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) offers a practical route to maki... |
41889745 | Suppressing Cell Migration through Discoidal Bottlebrush Copolymer Nanocarriers. | Precise control over two-dimensional (2D) polymer nanostructures remains a fundamental challenge, as polymer self-assembly overwhelmingly favors spherical morphologies. Here, we introduce a topology-driven design strategy that overcomes this limitation, enabling the predictable and modular formation of amorphous polyme... |
41889640 | Hybrid and conjugated antimicrobial peptides: new tactics to counter bacterial resistance. | The phenomenon of bacterial resistance has emerged as a significant challenge to global public health. Due to the increasing prevalence of antibiotic resistance, there has been interest in developing antimicrobial peptides (AMPs) as alternative antimicrobial therapies. However, AMPs resistance is not uncommon; it is si... |
41889639 | Identification of disease ameliorated metabolite candidates from Gut Microbes and their interacting targets based on a novel estimating function. | The gut microbiota plays a crucial role in human health and the progression of diseases. As key mediators of the interactions between gut microbiota and host diseases, metabolite changes have a significant influence on disease development and progression. However, without experimental validation by metabolomics, identi... |
41884842 | Smart control of CAR-T cells: emerging strategies for safer and more effective cancer immunotherapy. | Chimeric Antigen Receptor (CAR)-T cell therapy has developed cancer immunotherapy but remains restricted by severe toxicities, antigen escape, and loss of efficacy in solid tumors. Recent advances in smart control systems aim to enhance the safety and precision of CAR-T therapies through tunable, reversible, and contex... |
41884841 | Comprehensive methylome and transcriptome profiling reveals specific biomarkers for bovine viral diarrhea virus persistent infection in calves. | <h4>Background</h4>Persistently infected (PI) calves resulting from maternal Bovine viral diarrhea virus (BVDV) infection during early gestation are the main source of viral transmission and pose a serious threat to the sustainable production of herds. PI cattle appear clinically normal, elucidating the molecular-level... |
41884827 | Traditional clinical risk factors outperform disease activity and hematologic indices for FRAX hip fracture risk in rheumatoid arthritis. | <h4>Background</h4>Hip fractures are among the most devastating complications of osteoporosis, yet determinants of the Fracture Risk Assessment Tool (FRAX)-estimated 10-year hip fracture probability (FRAX-Hip) in rheumatoid arthritis (RA) remain incompletely defined. The incremental value of RA disease activity and com... |
41884785 | <i>In vitro</i> assays to monitor membrane fusion. | Membrane fusion is essential to maintain eukaryotic life. Fusion is tightly regulated and relies on a complex network of protein tethers and lipid interactions. This inherent complexity makes mechanistic investigation of membrane fusion challenging. Taking a reductionist <i>in vitro</i> approach has established a funda... |
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