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41884550 | Culture as a catalyst for regenerative co-creation: the role of yuanfen in driving customer voice through social bonds in P2P accommodation. | <h4>Introduction</h4>As tourism shifts from sustainability toward regeneration, active customer participation has become essential for revitalizing the peer-to-peer (P2P) accommodation sector. However, the cultural values that motivate such participation remain largely overlooked. Drawing on Cognitive Appraisal Theory,... |
41884531 | Application of multi-channel magnetic particle immunofluorescent disc microfluidic chip for combined detection of antibodies against six common infectious diseases including visceral leishmaniasis in pastoral areas. | <h4>Objectives</h4>This study aimed to develop a microfluidic chip for the simultaneous detection of specific antibodies against six common pathogens in pastoral areas. The specific detection targets include: visceral leishmaniasis (IgG against <i>Leishmania</i> soluble antigen, IgG against recombinant K39 antigen); cy... |
41884348 | E3 ubiquitin ligases: structural diversity, dysregulation in disease, and their emerging role in targeted therapeutic strategies. | The Ubiquitin-Proteasome System (UPS) is a key mechanism of cellular homeostasis. A central part of this mechanism is E3 ubiquitin ligases, which selectively direct proteins to be ubiquitinated for degradation via the UPS. In this review we give an integrated overview of the classification, structural and the functiona... |
41883974 | Investigating the functions and molecular mechanisms of DTX3L in cancer progression. | In the field of tumor research, the process by which E3 ubiquitin ligases specifically ubiquitinate substrate proteins and promote their degradation has garnered significant attention. DTX3L, an emerging E3 ubiquitin ligase of the Deltex family, is closely associated with the development and progression of various mali... |
41883787 | Maternal probiotic and prebiotic supplementation on glucose metabolism in pregnant women and their offspring: effects and related mechanisms. | <h4>Introduction</h4>The global diabetes epidemic has brought gestational diabetes mellitus (GDM) and its long-term impacts on maternal-child health into sharp focus. Emerging evidence indicates that early-life metabolic programing, mediated significantly by gut microbiota, profoundly influences offspring glucose homeo... |
41883506 | <i>In silico</i> and <i>in vitro</i> investigations of the drug-drug interaction mechanisms between fludarabine and busulfan. | <h4>Background</h4>Understanding drug interactions in hematopoietic stem cell transplantation (HSCT) is crucial given the narrow therapeutic index of busulfan (BU), which is a key conditioning agent. In this study, we investigate the potential impacts of fludarabine (Flu) as a frequently co-administered agent in HSCT o... |
41883499 | Multi-target computational pipeline for discovery of pan-influenza neuraminidase inhibitors. | The continuous evolution of influenza A and B viruses, coupled with the emergence of drug resistance, creates a pressing need for novel antiviral agents with broad-spectrum activity. The viral neuraminidase enzyme remains a prime target, but its structural variability across different strains complicates the discovery ... |
41883474 | Mapping the global landscape of biofilm-associated antimicrobial resistance (1992-2025). | Antimicrobial resistance (AMR) is a great global health threat, with biofilm formation recognized as a key microbial survival strategy that promotes persistence and recurrent infections. Despite growing mechanistic insights, research on biofilm-associated AMR ((biofilm-AMR)) remains fragmented, limiting the development... |
41874145 | Trace Elements and Viral Infectious Diseases: Dual Roles in Pathogenesis and Immunity. | <h4>Introduction</h4>Trace elements such as zinc, selenium, iron, copper, and manganese play a vital role in human health-especially in how the immune system responds and how the body handles viral infections. These trace elements have complex and sometimes context-dependent effects: while they can strengthen the body'... |
41869077 | Zein-based polysaccharide-tannic acid films as multifunctional barriers to prevent post-surgical adhesions. | Formation of postoperative adhesions remains a significant clinical burden, frequently leading to chronic pain, bowel obstruction, and infertility. Current physical barriers have shown limited success, highlighting the need for multifunctional antiadhesive structure that combine mechanical stability with finely tuned s... |
41868158 | Metal-centered X-ray absorption and emission spectroscopy of iron corroles: implications for ligand non-innocence. | Determining the electronic structure of transition metal complexes with non-innocent ligands is challenging, both experimentally and theoretically. In this study, we investigate the electronic structure of iron corrole nitrosyl (Fe[TPC](NO), TPC = <i>meso</i>-triphenylcorrole) using a combination of Fe L-edge and K pre... |
41847373 | Enzyme-specific modulation of rice peptide structure and alginate hydrogel functionality for food applications. | This study investigated how protease-specific hydrolysis modulates rice protein hydrolysate (RPH) structure and properties to tailor rice peptide‑sodium alginate composite hydrogels. Using Alcalase, Trypsin, and Flavourzyme (E/S: 3000-10,000 U/g), Flavourzyme yielded the highest hydrolysis (43.87%) and antioxidant acti... |
41846107 | Solvent-mediated biomimetic reversible assembly of supraparticles from polyphenol Janus nanosheets. | Achieving fully reversible disassembly-reassembly cycles in supraparticles remains a significant challenge, particularly with respect to developing methods that are facile, rapid, and require no surface functionalization. Inspired by reversible structural transition behavior of velvet worm slime, this study proposes a ... |
41833048 | Cyclodextrins-Phospholipids Complex Loaded Nanofibers for Improved Oral Bioavailability and Brain Targeting for Management of Stress and Anxiety. | Depression and anxiety have emerged as significant public health concerns worldwide, with conventional pharmacotherapy often limited by poor solubility, low bioavailability, and suboptimal brain targeting of therapeutic agents. To address these challenges, this study proposes a novel drug delivery system integrating cy... |
41832853 | Integrated complexation-precipitation and dispersive micro-solid phase extraction platform for non-targeted screening of non-volatile compounds in therapeutic monoclonal antibodies. | The non-targeted screening of non-volatile organic compounds (NVOCs) in Mab A (monoclonal antibody A) is challenged by matrix interference and stringent sensitivity requirements. To address this, an integrated platform combining complexation-precipitation and dispersive micro-solid phase extraction (D-μSPE) was develop... |
41832832 | Bioinspired engineering of breathable poly(lactic acid) metafabric with high-performance radiative cooling and wearable comfort. | Passive daytime radiant cooling (PDRC) represents a sustainable, energy-free technology for personal thermal management (PTM). However, conventional polymer membranes frequently exhibit insufficient solar reflectance and poor breathability. Herein, inspired by dictyophora, we propose a biomimetic gradient pore engineer... |
41832822 | Engineering 1 T-rich MoS<sub>2</sub>-tuned FeNiCo-based metal-organic framework heterostructure for enhanced oxygen evolution reaction activity. | The sluggish kinetics of the oxygen evolution reaction (OER) remains a major bottleneck for efficient water splitting. Despite being promising alkaline OER catalysts, most two-dimensional (2D) metal-organic frameworks (MOFs) undego kinetically uncontrolled reconstruction into metal (oxy)hydroxides (MOOH), leading to in... |
41831262 | Sonication integrated with micronization: structural modification to improve the in-vitro digestibility, functional, and antioxidant properties of red pepper seed protein isolate. | The study aimed to extract protein from red pepper seeds and to probe the effects of micronization (MN) at 15,000 rpm for 3 and 6 min, ultrasound (US) at 720 W, 40 kHz for 10 and 15 min, and their combined impact on red pepper seed protein isolate (RPSPI). The combined treatment (MN 6 min and US 10 min) substantially r... |
41825329 | Eu-MOF@Fe<sub>3</sub>O<sub>4</sub> nanocomposite with outstanding peroxidase-like activity and fluorescence for dual-modal colorimetric/fluorescence sensing of cholesterol. | Cholesterol (CHOL) is a key component of cell membranes and an essential nutrient. Abnormal levels of cholesterol can cause cellular degeneration and even lead to diseases. Therefore, how to monitor changes in cholesterol concentration sensitively and efficiently remains a significant challenge. Herein we report on Eu-... |
41821653 | Proteomic profiling of amylases secreted by <i>Penicillium crustosum</i> UEM-45 and characterization of two major enzymes. | Despite the industrial relevance of fungal amylases, those from <i>Penicillium crustosum</i> remain poorly characterized. This study aimed to use a proteomics-based approach to identify and characterize extracellular amylases from <i>P. crustosum</i> UEM-45. The extracellular proteome of <i>P. crustosum</i> UEM-45 was ... |
41822254 | Chronic Obstructive Pulmonary Disease and Overtraining Syndrome: A Narrative Review. | Chronic obstructive pulmonary disease (COPD) is a condition that inevitably leads to airflow limitation. COPD is among the leading causes of increased mortality and morbidity worldwide. A non-invasive and non-pharmacological approach is rehabilitation training, where the patient follows an active program to stimulate t... |
41819685 | Aliquat 336-functionalized metal-organic frameworks: An innovative strategy for the removal of trace lead ions. | Clean water is essential for all life, and lead (Pb) contamination continues to be a major concern due to its persistence, toxicity, and tendency to bioaccumulate. Effective and durable removal methods are required even at trace Pb(II) levels. For this, adsorption has become a straightforward, affordable, and efficient... |
41819445 | Promoting sustained behavior change and nutrition security in medicaid-enrolled individuals with stage 2 cardiovascular kidney metabolic syndrome (CKMS): Protocol of the SUSTAIN study. | <h4>Background</h4>Medicaid-enrolled populations are disproportionately impacted by suboptimal dietary intake leading to a high prevalence of Stage 2 cardiovascular-kidney-metabolic syndrome (CKMS), and lower Life's Essential 8 (LE8) cardiovascular health (CVH) measures.<h4>Methods</h4>A pilot randomized controlled tri... |
41816622 | Deep excitation afterglow luminescent probes for biomedical applications. | In addition to the high sensitivity, excellent spatio-temporal resolution and powerful real-time imaging capabilities, biomedical applications impose high demands on imaging techniques. Unfortunately, conventional imaging relies on the real-time excitation and suffers from limited tissue penetration. In contrast, after... |
41816614 | Amino acid appended supramolecular self-associating amphiphiles demonstrate dual activity against both MRSA and ovarian cancer. | Differences in the lipid composition of prokaryotic and eukaryotic cell membranes are well understood and can be exploited to produce novel antimicrobials. However, what is less well recognised is that alteration in the phospholipid composition of the cell membrane is also one of the first phenotypic changes when a cel... |
41815524 | Dibenzo-18-crown-6/poly-2-aminobenzenethiol based potentiometric sensor for diltiazem determination: greenness assessment. | A green, cost-efficient, highly selective, and sensitive carbon paste potentiometric sensor for Diltiazem hydrochloride (DTZ) was developed, described, and employed for drug monitoring. With a detection limit of 4.6 × 10<sup>-7</sup> mol L<sup>-1</sup>, the developed sensor exhibits a Nernstian slope of 57.4 ± 0.81 mV ... |
41815409 | Supercritical catalytic cracking of <i>n</i>-decane over microwave-synthesized hierarchical core-shell nano-Beta@SBA-15 composite zeolite. | Catalytic cracking of endothermic hydrocarbon fuels offers a promising regenerative cooling strategy for hypersonic propulsion systems, yet conventional microporous zeolite catalysts suffer from severe diffusion limitations and rapid coke deposition under supercritical conditions. This study develops a hierarchical cor... |
41815407 | Recent progress in the fabrication of nanocomposite-derived superhydrophobic coatings for improved concrete lifespan: insights into recent advancements, interfacial chemistry and tribological performance. | Concrete structures and built infrastructure are essential for modern civilization due to the increasing urbanization, population growth, and corresponding infrastructure needs. However, extreme weather and prolonged exposure to humidity can lead to the irreversible degradation of various materials used in built infras... |
41815402 | Green hydrogen pathways for a net-zero future: technologies, circular economy integration, life-cycle performance and safety dimensions. | This review critically evaluates the technological, environmental, and policy dimensions of green hydrogen using an integrated framework grounded in green chemistry, the circular economy, and the sustainable development goals. Rather than treating green hydrogen as a universal energy solution, the review synthesises ad... |
41815396 | Electronic reactivity and drug binding in doped cycloparaphenylenes: toward multifunctional platforms for biosensing and targeted drug delivery. | Cycloparaphenylenes (CPP) and their heteroatom-doped derivatives are emerging as interesting nanocarriers due to their adjustable electronic structures and π-conjugated frameworks. This study used density functional theory (DFT) to examine the structural, electrical, and adsorption characteristics of virgin CPP, nitrog... |
41815393 | Fabrication of self-assembled CuO nanosheets for the sustainable synthesis of 2-substituted 1,3-benzothiazoles. | We report the rapid, sustainable, facile, environmentally friendly synthesis of copper oxide nanosheets (CuO NSs) and their application as a nanocatalyst for the synthesis of 2-substituted 1,3-benzothiazoles. The CuO NSs were characterized by various analytical techniques, including UV-Vis, fourier transform infrared s... |
41808421 | Elastic Organic Crystals of Semiconducting Hydrocarbon Fully π-Conjugated Molecules for Efficient Flexible Ultra-Deep-Blue Amplified Spontaneous Emission Waveguides. | Efficient ultra-deep-blue light-emitting elastic organic crystals are promising candidates for flexible optoelectronics owing to their low defect density, regular intermolecular packing, and excellent mechanical stability. However, heteroatom-containing fully π-conjugated molecules (FπCMs) often undergo strong π-π stac... |
41808389 | B,N-Embedded Hetero[9]Helicene-Induced Chiral Assemblies for Amplified Circularly Polarized Electroluminescence. | Circularly polarized organic light-emitting diodes (CP-OLEDs) based on B,N-embedded heterohelicenes are promising due to their narrowband emission and high electroluminescence efficiency, yet their development has been hindered by intrinsically weak circularly polarized electroluminescence (CPEL) with dissymmetry facto... |
41808384 | Charge-Asymmetric Dual-Cu Sites in a Metal-Organic Framework Direct CO<sub>2</sub> Electroreduction to Ethanol. | The selective electrochemical CO<sub>2</sub> reduction reaction (CO<sub>2</sub>RR) to ethanol is constrained by copper's intrinsic kinetic preference for the ethylene-forming *CO→*COH pathway over the ethanol-selective *CO→*CHO route. Conventional solutions break this preference by introducing extrinsic chemical hetero... |
41808196 | RGReco: a unified framework for automated R-group recognition in chemical publications. | The abundant R-group information available in chemical publications plays a crucial role in data-driven artificial intelligence (AI) research in the field of medicinal chemistry. In real-world publications, R-groups are expressed in various textual and graphical forms, thereby rendering their manual integration labor-i... |
41808127 | Integrated strategies for mosquito-borne disease control: a comprehensive review with emphasis on repellents and China's practices. | Mosquito-borne diseases cause millions of deaths every year, imposing a heavy burden on global public health systems and socioeconomic development. In China, mosquito-borne diseases exhibit a pattern of imported cases leading to localized transmission, and in recent years, periodic outbreaks of related diseases have co... |
41808121 | Synergistic proanthocyanidin-copper oxygen-generating microneedle enhances anti-inflammatory activity in dental pulp stem cells and macrophage efferocytosis. | <h4>Background</h4>Dental pulp inflammation and impaired tissue repair remain critical challenges in endodontic therapy, often exacerbated by hypoxia and dysregulated immune responses.<h4>Methods</h4>We developed a procyanidin-copper-loaded oxygen-generating microneedle hydrogel (CA-PCC-CAT) releasing active components... |
41807680 | A fluorescent probe under the microscope showing dual recognition of B-DNA and G-quadruplex DNA. | The use of small molecules as fluorescent DNA markers has been extensively explored since the mid-1960s, revealing limitations in designing selective probes due to the largely missing relationship between probe structure and DNA conformation. Here, we present a multistep computational protocol applied to a recently pro... |
41807619 | Identification of intracellular target of antimicrobial peptide EWAMP-R in bacteria. | Antimicrobial peptides (AMPs) exhibit diverse antibacterial mechanisms. To elucidate the intracellular targets of the novel AMP, EWAMP-R, we generate EWAMP-R-resistant strains of Escherichia coli and Staphylococcus aureus. In E. coli, a nonsynonymous mutation in the clpX gene (1108 C > T) is identified, resulting in an... |
41807577 | In silico structural and functional characterization of high-risk missense variants in MMP8, GZMK, and OASL genes associated with epidemic viral infections. | This research explores the structural and functional consequences of high-impact missense variants in three immune-related genes MMP8 (D253N, Y261S), GZMK (A42P, L122P), and OASL (W216C) with possible relevance to host response in epidemic viral infections. A layered computational workflow was implemented to predict pa... |
41807554 | La-Ni-MOF(BDC) composite with graphene oxide for enhanced bifunctional electrocatalysis in electrochemical water splitting. | Highly efficient electrocatalysts use graphene sheets that are abundant in nature create considerable importance during the complete process of water splitting because they enable sustainable energy conversion and storage. Study presents metal-organic frameworks (MOFs) which researchers synthesize through hydrothermal ... |
41807504 | High-performance graphene oxide desalination membranes enabled by size-sieving, ion exclusion, and cation recognition mechanisms. | Graphene oxide (GO)-based membranes are promising for sustainable water purification due to their sub-nanometer interlayer channels, which provide ultrafast water transport and high salt rejection. However, they generally exhibit limited structural stability in aqueous media, leading to increased interlayer spacing and... |
41807495 | Waste-derived nano-Al₂O₃-loaded pyranopyrazole composite for high-capacity cadmium and methylene blue removal with mechanistic and DFT validation. | Upcycling industrial aluminum waste into functional adsorbent materials offers a sustainable strategy for addressing complex wastewater contamination by coexisting organic dyes and toxic heavy metals. In this study, a waste-derived nano-Al₂O₃-loaded pyranopyrazole composite is rationally designed to enable high-capacit... |
41807391 | Extracellular vesicle engineering using a small scaffold protein. | Extracellular vesicles (EVs) are promising drug-delivery vehicles owing to their biocompatibility and low immunogenicity. Genetic engineering of a membrane-bound EV-sorting scaffold protein empowers EVs by installing targeting moieties on the surface and enriching therapeutic cargo in the lumen. However, the choice of ... |
41807390 | Covalent warhead assembly in fostriecin biosynthesis involves malonylation-lactonisation by a bifunctional thioesterase and enzymatic demalonylation. | α,β-Unsaturated δ-lactones (AUDLs) are key pharmacophores of various polyketides exhibiting potent biological activity. Fostriecin has attracted interest as an anticancer agent, but its structural characteristics have limited its development and motivated investigations into biosynthesis-based production strategies. He... |
41807364 | Electrohydrodynamic printing technology: mechanisms, control, and applications. | Electrohydrodynamic (EHD) printing is an advanced micro/nanoscale additive manufacturing technique. Owing to its high-resolution capability, broad material compatibility, diverse printing modes, and low cost, it has attracted widespread attention. Nevertheless, significant challenges remain in transitioning EHD printin... |
41807359 | Strategies to control cellular spatial organization in microphysiological systems. | Spatial organization is fundamental to tissue physiology, as it governs how cells migrate, grow, differentiate, and interact within their native environments. In living tissues, cells are positioned within finely tuned microarchitectures defined by chemical gradients, boundaries, and mechanical cues - features that are... |
41807283 | Coordination-driven high sucralose loading, releasing and purifying performance of edible β-cyclodextrin metal-organic frameworks. | <h4>Background</h4>Sucralose (4,1',6'-trichlorogalactosucrose, TGS) has been widely used as a new generation of artificial sweetener, and the loading, release and purification of TGS with edible porous materials such as cyclodextrin metal-organic frameworks (CD-MOF) will pave a new way for the production and applicatio... |
41807269 | Glucose-Activated Nanoreactor Initiating Cascade Reaction to Remodel Immune Microenvironment for Promoting Diabetic Wound Healing. | Diabetic wound healing represents a formidable clinical challenge due to the complex pathological microenvironment characterized by hyperglycemia, persistent hypoxia, and excessive oxidative stress. Single-enzyme therapies struggle to address these issues in a coordinated and sequential manner. To overcome this limitat... |
41807047 | The CDKL5 kinase undergoes liquid-liquid phase separation driven by a serine-rich C-terminal region. | The <i>CDKL5</i> gene encodes a protein kinase involved in nervous system development and function. Pathogenic variants in this gene can cause a severe neurodevelopmental CDKL5 deficiency disorder (CDD). The CDKL5 protein contains a catalytic N-terminal domain (NTD) and a less characterized C-terminal domain (CTD). We ... |
41806334 | Self-Regulating Sodium-Ion Battery Materials: From Phase Reconstruction to Functional Activation. | Sodium-ion batteries are advancing toward practical deployment, yet their long-term durability is governed not by static material properties but by the coupled evolution of the lattice, interface, and electrolyte environments under operating conditions. However, a systematic consolidation of these dispersed mechanistic... |
41806230 | Self-Sensing NiFe@N-doped Carbon Aerogel: Integrating Excellent Radar Stealth, Inherent Structural Health Monitoring, Thermal Management, and Flame Retardancy. | Biomass carbon-based aerogels derived from collagen protofibrils are gaining considerable attention in electromagnetic protection. However, achieving a well-designed microstructure, optimized magnetic and dielectric loss components, and integrated multifunctionality within a single material system remains a significant... |
41806176 | Circularly Polarized Luminescence (CPL)-Active Homo- and Heterostructures by Surface-Catalyzed Secondary Supramolecular Polymerization. | Surface-catalyzed secondary nucleation is well-known in protein aggregation but underexplored in supramolecular polymerization of π-systems. Herein, we report a unique example of multistep secondary nucleation-dominated controlled supramolecular polymerization of an amide-functionalized naphthalene monoimide derivative... |
41806087 | Polyphenol-Gated Composite Electrolytes with Enhanced Cross-Phase Lithium-Ion Transport for Solid-State Lithium Batteries. | <h4>Highlights</h4>A biomimetic polyphenol-gated strategy is proposed to promote interfacial Li<sup>+</sup> - selective transport in composite solid electrolytes by chemically bonding the polymer matrix and ceramic nanofibers. The polyphenol interlayers serve as the chemical gates with -OH and -NH groups to immobilize ... |
41806079 | Metabolic reprogramming in cancer: dysregulation of glucose, lipid, and amino acid pathways and therapeutic opportunities. | Metabolic reprogramming is a hallmark of cancer, including hepatocellular carcinoma (HCC). Cancer cells exhibit enhanced glucose and glutamine uptake, increased glycolysis, pentose phosphate pathway activity, de novo lipogenesis, and altered amino acid metabolism. However, the metabolic crosstalk underlying cancer prog... |
41806069 | Manipulating Interphase Chemistry by Endogenous Doping Toward High-Performance Hard Carbon Anodes for Sodium-Ion Batteries. | The practical of hard carbon (HC) anodes in sodium-ion batteries is primarily limited by their unsatisfactory initial coulombic efficiency (ICE), cycling stability and rate performance, which are closely related to their interphase chemistry and microstructure. Herein, a unique manipulating interphase chemistry strateg... |
41805947 | Genomic and phylogenomic exploration of Vibrio cholerae strain SU129B isolated from Penaeus vannamei: Resistance, virulence, and evolutionary dynamics in bangladeshi aquaculture. | Vibrio cholerae, a globally significant pathogen, causes both endemic and epidemic cholera and has also been associated with sporadic gastroenteritis and foodborne infections. Shrimp exports are a key source of revenue and employment in Bangladesh. However, Vibrio outbreaks pose serious public health and socio-economic... |
41805899 | Unraveling the synergistic adsorption mechanism via DFT: SUPRADES-functionalized CMPs for highly sensitive detection of thidiazuron. | A novel synergistic adsorbent was developed by integrating supramolecular deep eutectic solvents (SUPRADES) with dynamic recognition properties into conjugated microporous polymers (CMPs) via a supramolecular functionalization strategy, which was successfully employed for the quantification of trace thidiazuron (TDZ) i... |
41805761 | The adeno-associated virus Rep proteins target PP4:SMEK1 by preventing substrate recruitment. | Despite the widespread use of adeno-associated virus (AAV) vectors in gene therapy, their clinical efficacy and large-scale manufacturing remain constrained by an incomplete understanding of the virus-host interactions that govern AAV gene expression and replication. Here, we identify the PP4:SMEK1/2 phosphatase comple... |
41805577 | Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly. | The HIV-1 capsid is a fullerene cone composed of hexameric and pentameric capsid proteins (CA) that packages the viral genome and mediates nuclear entry. Lenacapavir (LEN), a potent molecular long-acting inhibitor developed by Gilead, disrupts capsid morphogenesis by binding a phenylalanine-glycine (FG) pocket at the i... |
41805575 | Mixed-mobility supported lipid bilayers uncover the role of immobilized ICAM1 on T cell activation and immune synapse organization. | The immunological synapse (IS) integrates antigen recognition and adhesion to control T cell activation and effector functions. Reductionist systems have been instrumental in dissecting IS organization, but conventional systems constrain all ligands to be either mobile or immobile, unlike antigen-presenting cells where... |
41805574 | The <i>Mycobacterium smegmatis bd</i>-II terminal oxidase employs a carboxylate shift mechanism. | Cytochrome <i>bd</i> is a terminal oxidase expressed under low oxygen conditions and central for the survival of many pathogens. Here, we characterize the cyt <i>bd</i>-II from <i><i>Mycobacterium</i> smegmatis</i>, a member of a hitherto uncharacterized evolutionary group (qOR-2) of <i>bd</i> oxidases, by combining bi... |
41805571 | A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants. | Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, when flooded. In vascular plants, transcriptional adaptive responses to hypoxia are rapidly mounted by Ethylene Response Factors VII (ERFVIIs), regulated by Plant Cysteine O... |
41805565 | Crystal structure of <i>Vibrio cholerae</i> polysaccharide lyase RbmB bound to <i>Vibrio</i> polysaccharide (VPS) fragments provides insights into substrate recognition and cleavage. | Exopolysaccharides are carbohydrate polymers secreted by bacteria to perform various roles including adhesion to surfaces, protection from environmental stressors, and as key components in the production of biofilms. The human pathogen <i>Vibrio cholerae</i> produces an exopolysaccharide called VPS, which is essential ... |
41805377 | Tunable Dynamic Excimer Formation in Bisphenalenyl Derivatives through Molecular Packing. | Dynamic excimer formation in solution-phase π-conjugated systems presents a promising route toward tunable photophysical properties, yet precise control over these transient species remains limited. Herein, a series of bisphenalenyl derivatives is shown to exhibit excimer emission that is modulated through strategic ta... |
41805374 | Combined Experimental and Computational Study on the Structure-Property Relationships of Mono- and Dicationic Imidazolium Ionic Liquids for CO<sub>2</sub> Capture. | The present study investigates the potential of dicationic ionic liquids (DILs) and monocationic ionic liquids (MoIL), with and without metal in the anion, for CO<sub>2</sub> capture applications. The structures of the samples were confirmed by FTIR, <sup>1</sup>H NMR spectroscopy, and Raman spectroscopy, while their p... |
41805362 | Practical Rh-ZhangPhos Catalyzed Asymmetric Hydrogenation of Enamides: From Scalable Access to Mechanistic Insight. | Herein, we report a simple, one-pot, scalable process for the preparation of a series of enamides, which were subsequently hydrogenated with high efficiency and excellent enantioselectivity to the corresponding chiral amides using the Rh-ZhangPhos catalyst. This methodology is practical and facilitates easy postreactio... |
41805357 | The <i>Borreliella burgdorferi</i> BosR-associated small non-coding RNA BasA regulates virulence. | Post-transcriptional regulation is an adaptive response used by living systems to alter protein levels independently of transcription initiation. In bacteria, one mechanism of post-transcriptional regulation involves the binding of small, non-coding RNAs (sRNAs) to target mRNAs to regulate their translation into protei... |
41805321 | Enhanced Transcytosis and Retention (ETR) of Drug Delivery Nanocarrier in Solid Tumors. | ConspectusTranscytosis, traditionally regarded as biological, constitutes an intrinsic and powerful pathway for macromolecule transport across endothelial and epithelial barriers. The emerging concept of Enhanced Transcytosis and Retention (ETR) is distinct from passive extravasation or tissue leakiness. It recasts nan... |
41805315 | A Redox-Responsive Selenium-Containing Nanomedicine Enables Dual Antioxidant System Inhibition to Overcome Platinum Resistance and Enhance Immunotherapy in Bladder Cancer. | Cisplatin-based chemotherapy is the standard first-line treatment for bladder cancer, but its efficacy is limited by drug resistance. Immune checkpoint blockades have emerged as promising therapeutic options; however, their benefits are restricted by the immunosuppressive tumor microenvironment and low response rates. ... |
41805309 | From Covalent Systems to Bulk Phases: Addressing Structural Complexity with Computational NMR. | ConspectusThe free induction decay (FID) signal acquired in a typical NMR experiment contains information about the chemical shifts, δ, and the spin-spin coupling constants, <i>J</i>, of the system investigated. These two parameters, particularly the chemical shifts, are very sensitive to both intramolecular and interm... |
41805192 | Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during <i>L. major</i> infection and promote host defense to infection. | Cutaneous leishmaniasis (CL) is a debilitating neglected tropical disease characterized by lesions that can range from self-healing to permanent disfiguration. A predominant Th1 response, which stimulates IFN-γ production, is crucial for parasite control during self-healing CL. While IFN-γ primarily activates macrophag... |
41805135 | Development and bioavailability testing of an estetrol and estetrol-zinc-containing vaginal hydrogel: a novel hydroxyethyl cellulose and hydroxypropyl-β-cyclodextrin-based formulation. | <h4>Objective</h4>Genitourinary syndrome of menopause (GSM) significantly impacts postmenopausal women, yet conventional treatments, such as vaginal estrogen creams, have limitations related to adherence and efficacy. This study aims to develop and evaluate a novel hydroxyethyl cellulose (HEC)-based bioadhesive vaginal... |
41805061 | Morphology Regulation of CoMn-MOF Derived Composites Anchored on Carbon Foam for Enhanced Microwave Absorption and Thermal Insulation Performance. | Magnetic porous carbon foams, with low density, strong attenuation, and improved impedance matching, have been introduced as effective microwave absorbers to combat electromagnetic interference. In this study, morphology regulation of CoMn-MOF derived composites anchored on carbon foam were prepared by in situ growth a... |
41805028 | Unlocking an Efficient SOD-to-CAT Catalytic Relay in a MOF Nanozyme via Dopamine-Driven Interfacial Nanoreconstruction for Osteoarthritis Therapy. | Osteoarthritis (OA) is driven by a vicious cycle of inflammation and reactive oxygen species (ROS). While cobalt-based metal-organic framework (MOF) nanozymes are potent catalase (CAT) mimics, their therapeutic efficacy is crippled by an inherently weak superoxide dismutase (SOD)-like activity that prevents full-chain ... |
41804801 | The Role of Reactive Species in Modulating Stilbene Biosynthesis in Grapevine Cells. | The stilbene trans-resveratrol is a key specialized metabolite in grapevine (Vitis vinifera), known for its notable antioxidant, anti-inflammatory, and anticancer properties. Its biosynthesis is primarily induced under stress conditions and can be enhanced in grapevine cell cultures using elicitors such as cyclodextrin... |
41804780 | Decoding the Principles Governing Molecular Cage Precipitation of Aliphatic and Perfluoroalkyl Acids (PFAAs). | Perfluoroalkyl acids (PFAAs) are surfactants that rank among the most persistent and hazardous anthropogenic pollutants. Molecular cages have emerged as promising remediation agents, enabling the straightforward isolation and purification of PFAAs through selective binding and precipitation. However, critical gaps rema... |
41804698 | Out-of-Equilibrium Supramolecular Assembly Sustained by Photocatalysis. | Some supramolecular structures persist because they are stable; others persist because they work. Here, we report a platinum(II) supramolecular system in which catalytic activity is uniquely associated with a far-from-equilibrium aggregate. The complex forms two emissive species: a kinetically trapped, orange-emissive ... |
41804650 | Light-Induced Binding and Reduction of CO<sub>2</sub> over Transient Open Ce(III) Sites in a Metal-Organic Framework. | Metal-organic framework (MOF) materials share some common features with metalloenzymes including site-isolated metal centers that template dynamic substrate activation within a functionalized cavity or pocket. We report the light-induced reversible binding of CO<sub>2</sub> in a cerium-based MOF, Ce-UiO-66-NH<sub>2</su... |
41804639 | Unlocking Synergistic Ligand-Metal Interplay in Dual Redox-Active Metal-Organic Framework for High-Efficiency and Durable Overall Water Splitting. | The development of bifunctional electrocatalysts that efficiently operate for both the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in a single electrolyte under high current density remains a critical challenge toward applied overall water splitting. Herein, we designed a robust and microporou... |
41804578 | The paradox of gold-liposome nanohybrids: the location of gold governs unconventional properties and drives cellular behavior. | The physicochemical characteristics of nanoparticles (NPs) and the cell type they encounter impact cellular interactions. Yet, which parameters should be precisely controlled to direct endocytosis in specific cell types remains paradoxical. Here, we designed gold-liposome nanohybrids (GLNs) and demonstrated for the fir... |
41804562 | Synthesis of Conjugated Linear and Cyclic Polyynes by Selective Alkyne Metathesis. | The formation of polyynes with an odd number of conjugated triple bonds is synthetically demanding, particularly for complex architectures, since most established methods rely on irreversible C-C bond-forming reactions and operate under kinetic control. To address this problem, we have developed the synthesis of triyne... |
41803567 | Innovative hybrid molecularly imprinted sensor for the detection of the antioxidant biomarker catalase. | In this study, a novel hybrid molecularly imprinted polymer (MIP)-based biomimetic sensor was fabricated, optimized, characterized, and applied for the electrochemical recognition of catalase (CAT), an antioxidant biomarker. A layer-by-layer approach was followed to prepare the hybrid sensor. First, silver nanoparticle... |
41803297 | TRMT6-directed m<sup>1</sup>A modification initiates lung squamous cell carcinoma via YTHDF3-stabilized cell cycle genes. | N<sup>1</sup>-Methyladenosine (m<sup>1</sup>A) is a prevalent RNA modification that governs RNA metabolism, structure, stability, and translation. Yet its cancer-wide landscape and functional impact remain largely unexplored. Here, we delineate the m<sup>1</sup>A regulatory network in lung squamous cell carcinoma (LUSC... |
41803170 | Elucidating the rate-limiting step of CO<sub>2</sub> electroreduction on metal phthalocyanines. | Immobilized molecular catalysts, especially metal phthalocyanines, have garnered substantial interest for the electrochemical CO<sub>2</sub> reduction reaction (CO<sub>2</sub>RR) due to their well-defined active sites and promising performance. Yet, the reaction mechanism, particularly the rate-limiting step, remains d... |
41738644 | Unlocking the chemistry of the octahydrotriborate anion: robust synthesis, structural elucidation, and unprecedented protonation stability of diamine-substituted derivatives. | A novel synthetic methodology for the preparation of amino-substituted derivatives of the octahydrotriborate anion has been developed, based on the direct reaction of the [B<sub>3</sub>H<sub>8</sub>]<sup>-</sup> anion with amine hydrochlorides. Additionally, the established approach involving the formation of the key [... |
41736679 | Red CPL from water insoluble achiral carbon dots assisted by cyclodextrin MOF templating. | Achiral water-insoluble red carbon dots (CDs) with improved quantum yield were prepared by co-pyrolysis of sodium lignosulfonate and 1,8-diamine naphthalene. Circularly polarized luminescence (CPL) from achiral CDs was induced by the first preparation of a polymorph of cyclodextrin metal organic framework (MOF), which ... |
41736657 | Understanding the potential of a new zinc-triazolato-carbonate metal-organic framework for humid CO<sub>2</sub> capture processes. | A new pillared-layer triazolato-carbonate metal-organic framework (MOF) was synthesized. This readily accessible ultramicroporous MOF showed good CO<sub>2</sub> uptake. Intrigued by its relatively hydrophobic nature, we have investigated its capability for humid CO<sub>2</sub> capture processes. |
41734102 | A bismuth-based metal-organic framework with potential application in organic pollutant removal. | Metal-organic frameworks (MOFs) with structural diversity and functional versatility have shown great potential in many fields. In this work, we proposed the utilization of the good biocompatibility and photoactivity of bismuth to construct new MOFs with potential application in high-performance photocatalysis. A new b... |
41725572 | Nicotinoyl hydrazone-directed vanadium assemblies: metallosupramolecular isomerism, polymorphism, and catalytic oxidation performance. | A systematic investigation of coordination-driven vanadium assemblies reveals a rich structural landscape in which tetrameric metallacycles [VO(VanNH)(OR)]<sub>4</sub> and 1D polymeric species [VO(VanNH)(OR)]<sub><i>n</i></sub> form selectively, depending on reaction conditions and the nature of auxiliary alkoxide liga... |
41711749 | Design and synthesis of Zn(II)/Cd(II)-based energetic metal coordination polymers with the bis(tetrazole)methane (H2btm) ligand: a comparative assessment of heat resistance and catalytic effects on the thermal decomposition of ammonium perchlorate. | We report two energetic metal coordination polymers (CPs), [Zn(Hbtm)<sub>2</sub>]<sub><i>n</i></sub> (1) and [Cd<sub>3</sub>(btm)<sub>2</sub>Br<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>]<sub><i>n</i></sub>·4H<sub>2</sub>O (2), based on the bis(tetrazole)methane (H2btm) ligand. SCXRD analysis shows that 1 forms a 2D layer... |
41705918 | Tetrazine-functionalized UiO-68 for highly selective Au(III) recovery from acidic solutions. | A tetrazine-functionalized zirconium MOF, UiO-68-TZDC (isostructural with UiO-68-TPDC), is constructed through a one-pot solvothermal synthesis for the selective recovery of Au(III) from acidic chloride media, using UiO-68-TPDC as a tetrazine-free, isostructural counterpart. The obtained crystalline materials possess g... |
41701482 | Unveiling the role of structural water and achieving enhanced Zn-ion storage <i>via</i> thermal dehydration of a Ni-containing heteropolyoxovanadate cathode. | The widespread adoption of aqueous zinc-ion batteries (AZIBs) is constrained by cathode materials with limited capacity and poor structural stability. Herein, we present the systematic exploration of thermal dehydration as a strategic tool to activate a nickel-containing heteropolyoxovanadate cathode. The precursor, Na... |
41677360 | Synthesis of crown ether-capped highly symmetrical fluoride-centered lanthanide clusters [Ln<sub>6</sub>F<sub>13</sub>(12-crown-4)<sub>6</sub>]I<sub>3</sub>F<sub>2</sub> (Ln = Ho, Er). | We report two lanthanide clusters [Ln<sub>6</sub>F<sub>13</sub>(12-crown-4)<sub>6</sub>]I<sub>3</sub>F<sub>2</sub> (Ln = Ho, Er) synthesized through facile one-pot reactions of LnI<sub>3</sub>, 12-crown-4 and AgBF<sub>4</sub> in a 1 : 2 : 1 ratio at room temperature. Both complexes represent rare examples of highly sym... |
41993617 | Cell-drug conjugates: a novel drug delivery system for cancer therapy. | Cell-drug conjugates (CDCs) represent an advanced drug delivery platform that combines living cells with therapeutics, leveraging the biological properties of cells to achieve precise targeting. By conjugating drugs onto cell surfaces, CDCs preserve cell viability and achieve functional collaborative therapy between th... |
41982727 | Design, Synthesis and Biological Evaluation of Oxadiazole-Biphenyl Derivatives as Small Molecule Inhibitors Targeting PD-1/PD-L1 Immune Checkpoint. | Monoclonal antibodies (mAbs) targeting programmed cell death protein-1 and its ligand 1 (PD-1/PD-L1) have demonstrated significant efficacy in cancer immunotherapy. However, mAbs still have limitations in pharmacokinetic properties and immunogenicity. As a complementary approach, PD-1/PD-L1 small molecule inhibitors ha... |
41978904 | A multifunctional EGCG/Si nanohybrid-coated 3D-printed porous scaffold for bone defect repair. | Besides enhancing osteogenesis and angiogenesis, designing multifunctional scaffolds with immunomodulatory capabilities offers a promising strategy for managing bone defects. Herein, a 3D-printed scaffold modified with inorganic silicon (Si) ions and the polyphenol epigallocatechin gallate (EGCG) was constructed as an ... |
41978641 | Challenges and solutions for upstream processing of complex biologics. | Unlike conventional monoclonal antibodies, complex biologics-such as bispecific antibodies and fusion proteins-often face challenges including lower expression levels, higher mispairing rates, and greater sensitivity to culture conditions, which can collectively limit both titer and product quality. Leveraging process ... |
41943295 | Integrated in silico design of self-assembled herbal bioactives-polysaccharides nanoformulation for targeted therapy against gastric pathogen Helicobacter pylori. | Bioactive polysaccharides and herbal compounds exhibit intrinsic antibacterial activity against the gastric pathogen Helicobacter pylori, but their therapeutic efficacy is limited by poor oral bioavailability, nonspecific distribution, and instability during self-assembly. Here, we integrated molecular dynamics and den... |
41934998 | Mg<sup>2+</sup>-driven triple nucleic acid cascades amplify Ru-encoded bimetallic MOF sign PFOA monitoring. | Perfluoroalkyl substances (PFAS) represent significant environmental hazards due to their exceptional persistence and propensity for bioaccumulation. However, current detection methodologies lack the ultra-trace sensitivity necessary to meet regulatory standards. In this study, we present an innovative electrochemilumi... |
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