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41908443 | Gualou-Xiebai-Baijiu Decoction Ameliorates Atherosclerosis by Inhibiting the ARG1/l‑Arg/NO Pathway: A Study Based on Network Pharmacology. | This study explored the potential mechanisms of action of Gualou-Xiebai-Baijiu Decoction (GXBD) in the treatment of atherosclerosis (AS) by integrating computational analyses with preliminary animal experiments. The putative targets of blood-absorbed components in GXBD were obtained and then intersected with AS-related... |
41901750 | Immunoinformatic Design and Evaluation of a Multi-Epitope mRNA Vaccine RP14914P Targeting Latent Tuberculosis Infection. | <b>Background</b>: Latent tuberculosis infection (LTBI) is the principal reservoir for active tuberculosis, with >85% of cases attributable to reactivation. Bacillus Calmette-Guérin fails to block this transition, leaving a critical gap in prevention. <b>Methods</b>: An immunoinformatics/reverse-vaccinology pipeline wa... |
41900958 | Prevalence of Low Bone Density and Fracture Risk Assessed with the FRAX Tool in German Patients with Axial Spondyloarthritis: A Cross-Sectional Study. | <h4>Introduction</h4>Chronic inflammation in axial spondyloarthritis (axSpA) promotes osteoclast formation and bone resorption, leading to osteoporosis and an increased risk of fragility fractures. Osteoporotic fractures significantly impact the quality of life in patients with axSpA. While the Fracture Risk Assessment... |
41900823 | From Eradication to Holistic Regeneration: Pharmaceutics Strategies for Reshaping Gastric Homeostasis Against <i>H. pylori</i> Infection. | Although the eradication of <i>Helicobacter pylori</i> is critical for preventing gastric cancer, current therapies often overlook the restoration of the gastric microenvironment, leading to a prevalence of delayed tissue healing and dysbiosis. Consequently, many patients remain in a persistent pathological state despi... |
41900368 | Reclaiming the Microbial Battlefield: Adjuvant Strategies to Overcome Antibiotic Resistance. | The escalation of antibiotic resistance constitutes a significant global health crisis, urgently demanding innovative strategies to restore and amplify the effectiveness of our existing antimicrobial arsenal. This review systematically explores the diverse landscape of antibiotic adjuvants, beginning with an elucidatio... |
41897486 | Applications of Antioxidant Nanoparticles, 2nd Edition. | It is known that the overproduction of reactive oxygen species (ROS), which regulate numerous physiological processes, can generate oxidative stress, responsible for the onset of several pathologies [...]. |
41893556 | An ELISA-Based Alternative to Mouse Bioassays for Quantitative Evaluation of Tetanus Toxin. | Tetanus toxin evaluation has traditionally relied on mouse LD<sub>50</sub> bioassays, which require extensive animal use and time, necessitating development of alternative methods in accordance with 3R principles (Replacement, Reduction, and Refinement). We developed and validated a sandwich enzyme-linked immunosorbent... |
41893186 | From Lab to Chairside: Dentists' Perception of Natural Nanomaterials and Smart Delivery Systems in Regenerative Dentistry. | <h4>Background</h4>The clinical translation of natural nanomaterials and smart delivery systems in regenerative dentistry relies heavily on practitioner acceptance; however, end-user perspectives remain under-investigated.<h4>Objective</h4>This study evaluated dental practitioners' self-reported knowledge, attitudes, a... |
41889754 | Continuous Flow Photocatalysis for Sustainable Chemical Conversions. | Photocatalytic chemical conversion shows a bright future in sustainable synthesis but encounters great challenges in scale-up. Photocatalysis in flow is considered as a solution for maximizing light absorption and mass transfer of reactants and thus has attracted fundamental and applied research. This perspective provi... |
41878572 | Advancements in aptasensors development for the detection of zearalenone. | Zearalenone (ZEN), an estrogenic mycotoxin produced by <i>Fusarium</i> species, is a frequent contaminant in cereals and other agricultural commodities. Its presence poses substantial economic losses, threatens food safety, and presents significant risks to human health, making it a growing concern worldwide. Consequen... |
41878489 | Triglyceride-glucose index and atherogenic index of plasma as predictors of cardiovascular risk in rectal cancer survivors. | <h4>Background</h4>Rectal cancer survivors face elevated cardiovascular disease (CVD) risk, but simple metabolic indices for risk stratification remain underexplored. We investigated associations of triglyceride-glucose index (TyG) and atherogenic index of plasma (AIP) with secondary CVD in rectal cancer patients.<h4>M... |
41878418 | Microfluidic engineering of immune-competent organs-on-chips and their applications. | The emerging field of biomimetic microfluidics is advancing the engineering of immune-competent Organs-on-Chips. These systems overcome the constraints of conventional models by using precise microengineering to regulate cellular composition, three-dimensional extracellular matrix architecture, and dynamic biophysical ... |
41878262 | Pathobiology of ESKAPE Biofilms in implant infections: current understanding and implications for future therapeutic strategies. | In the modern era, the expanding demand for implants has transformed the healthcare system by restoring and enhancing the function of various biological structures, thereby increasing the patients' quality of life. These include urinary catheters, dental, orthopedic, cardiovascular implants, and sutures designed to per... |
41877782 | Identification of plasma biomarkers in a PTZ-induced Sudden Unexpected Death-like model through integrated proteomics and metabolomics methods. | <h4>Introduction</h4>Sudden Unexpected Death in Epilepsy (SUDEP) refers to the unexplained, sudden death of individuals with epilepsy, and its incidence is closely linked to the severity and duration of seizures. This study aimed to identify plasma biomarkers associated with SUDEP through a combined proteomics and meta... |
41863980 | Tannic acid supplementation exerts biphasic effects on growth performance, immune function, and gut microbiota in Pekin duck. | Tannins, which are polyphenols present in several plant species, have been shown to exert several beneficial effects in livestock at specific levels. However, the optimal dosage for growth promotion in waterfowl like Pekin ducks remains unclear. Therefore, this study aimed to investigate the effects of dietary tannic a... |
41859178 | Biophysical characterization of <i>sp</i>Cas9 binding and cleavage using real-time electronic biosensors. | CRISPR-Cas9 enables curative genome editing but requires precise control of target recognition, particularly when single-nucleotide polymorphisms (SNPs) influence specificity. Conventional biochemical and optical assays often rely on endpoint or ensemble-averaged measurements and therefore fail to resolve the real-time... |
41853609 | Effects of the flowering process on the metabolite profiles and bioactivities of Shaanxi Fu brick tea. | This study investigated the impact of "flowering" process (<i>Aspergillus cristatus</i>-mediated fermentation) on the quality of Shaanxi Fu brick tea. Metabolic profiles of twenty samples, collected before (BF) and after (AF) fermentation were analysed. Moreover, <i>in vitro</i> assessments of their antioxidant and hyp... |
41852581 | Quercetin alleviates CCl<sub>4</sub>-induced liver fibrosis via regulating gut microbiota and the AGE-RAGE/PI3K/Akt signaling axis. | The absence of clinically effective anti-fibrotic agents for chronic liver disease represents a critical therapeutic gap. Although the flavonoid quercetin exhibits potent experimental anti-fibrotic activity, its full integrative mechanisms-particularly those involving gut-liver axis crosstalk and specific signaling pat... |
41847561 | Spatiotemporal immunomodulation with programmable biomaterials to promote musculoskeletal tissue regeneration. | Musculoskeletal disorders (MSDs), encompassing a variety of degenerative and inflammatory conditions, are frequently associated with immune dysregulation. This dysregulation can result in significant pathological changes within the tissue microenvironment, including abnormal inflammatory responses, biochemical and biop... |
41847303 | Distinct hyaluronan content and hierarchical organization of collagen-elastic fiber assemblies in subcutaneous fascia. | Previous studies have demonstrated that the subcutaneous fascia is a continuous connective tissue layer consisting of morphologically distinct "loose regions" and "dense regions". However, the molecular basis of this regional heterogeneity remains unclear. This study aimed to analyze the biochemical and compositional d... |
41847294 | Synthesis and anti-cancer activity of naphthalimide-organylselanyl conjugates. | The structure-based approach remains a valuable tool for rapid and high-throughput drug discovery and lead optimisation. In this study, we report the in-silico modelling and anticancer activity of two 1,8-napthalimide (NAP) derivatives containing organyl selanyl groups. The organylselanyl function <i>n</i>-octylselanyl... |
41847293 | Cone <i>p</i>-aminocalix[4]arenes enriched with 'clickable' alkyne or azide functionalities. | Efficient approaches have been developed for the synthesis of heteromultifunctional cone calix[4]arenes containing four amino groups at the wide rim and one, two or four propargyl or 2-azidoethyl groups at the narrow rim of the macrocycle, which can be used for expanding functionalization of the calixarene core in the ... |
41836539 | Polymorphism-driven coordination geometry engineering for boosting nitrate electroreduction in Cu-pyrazolate chains. | Tailoring the coordination geometry of metal centers through polymorphism offers a powerful approach to isolating the structural origin of catalytic activity in metal-organic frameworks (MOFs). Herein, two copper-pyrazolate (Pz) polymorphs, α-Cu(Pz)<sub>2</sub> and β-Cu(Pz)<sub>2</sub> were synthesized, featuring ident... |
41836543 | Two-dimensional Pd-C bonded organometallic framework with dynamic packing transformations. | Traditional metal-organic frameworks (MOFs) are predominantly constructed through metal-oxygen (M-O) or metal-nitrogen (M-N) coordination bonds. However, the limited softness of M-O and M-N bonds restricts the incorporation of softer linkages involving low-valent or noble metals, as described by the hard-soft acid-base... |
41829877 | Unveiling Plant Metabolic Diversity: Integrating Metabolomics with Multi-Omics Approaches for Crop Improvement. | Metabolomics, representing the biochemical phenotype of cells or tissues, serves as an intrinsic factor underlying the differences in plant traits. Recent advances in multi-omics technologies have significantly deepened our understanding of plant metabolic diversity, enabling researchers to dissect complex biochemical ... |
41828896 | Insights into the Enhanced Tetracycline Adsorption by Two-Dimensional Cu-Based Metal-Organic Framework. | Accumulation of tetracycline (TC) in aquatic environments poses a significant threat to human health and ecosystems, driving the need for efficient removal technologies. Two-dimensional metal-organic frameworks (2D MOFs) are promising adsorbents due to their tunable structures and abundant active sites. In this work, t... |
41828888 | Boosting Photocatalytic CO<sub>2</sub> Cycloaddition via Dual-Active Site Coordination over Amino-Functionalized UiO-66(Zr). | CO<sub>2</sub> cycloaddition with epoxides offers a sustainable route for CO<sub>2</sub> utilization, yet the simultaneous activation of both substrates remains challenging. Herein, using UiO-66(Zr)-NH<sub>2</sub> (denoted as UZN) as a model system, we illustrate that dual-active sites consisting of unsaturated Zr<sup>... |
41825200 | Metal-organic frameworks for nuclear waste remediation: A review of cutting-edge advances and applications. | Metal-organic frameworks (MOFs) have emerged as revolutionary adsorbents for nuclear waste remediation compared to conventional adsorbents due to their exceptional properties including high surface areas, tunable pore structures, and customizable functionalities. This comprehensive review highlights cutting-edge innova... |
41812878 | Aromatic Residue-Rich Amino-terminal Segments of Temporin L Self-Assemble into Collagen-Mimetic Peptides with Cell-Adhesion Properties. | Intriguingly, 13-mer frog-peptide, temporin L (TempL) contains 50% aromatic residues within its first eight residues. Considering the role of aromatic residues in self-assembly of peptides and the potential of such peptides in biomedical applications, we envisaged to identify new short self-assembling peptides from the... |
41810626 | Lipidic composition and thermal stability of oils from Dipteryx alata, Acrocomia totai, Mauritia flexuosa and Caryocar brasiliense. | Vegetable oils have various types of applications, one of which is food. Dipteryx alata ("baru" or tonka bean) and Acrocomia totai ("bocaiuva", or macaw palm) nuts, Mauritia flexuosa ("buriti", or buriti palm), and Caryocar brasiliense ("pequi", or pequi fruit) pulps are sources of unsaturated lipids. By performing qua... |
41809941 | Surface Engineering of MXenes for Biomedical Uses: Functionalization Strategies and Application Trends. | MXenes, a class of 2-dimensional transition metal carbides and nitrides, have emerged as highly versatile materials in the biomedical field because of their high electrical conductivity, hydrophilicity, large surface-area-to-mass ratio, and compositional versatility. Despite their promise, the inherent instability in p... |
41809668 | Chemical and morphological evolution of hybrid conversion coatings in low-Earth orbit space environment. | Understanding how protective coatings respond to the harsh low-Earth orbit (LEO) environment is essential for ensuring the safety, longevity, and cost-effectiveness of spacecraft. In particular, identifying environmentally friendly, non-chromate alternatives that can maintain performance under such conditions has both ... |
41809662 | Using PdO-incorporated MOF-derived sandwich heterostructures for enhanced glucose sensing. | Blood glucose concentration plays a vital role in the clinical diagnosis and therapeutic monitoring of diabetes mellitus. Accurate measurement and continuous monitoring of glucose levels are essential for effective disease prevention and management. However, conventional detection methods face significant limitations i... |
41809659 | Interplay of defects and dopants in <i>l</i>-Dopa -aided UiO-66 for superprotonic conductivity. | The growing demand for renewable energy sources has promoted PEMFC technology, where MOFs have emerged as an inexpensive, stable, and eco-friendly alternative to the state-of-the-art Nafion. Separate classes of functionalized and doped MOFs are explored with high conductivity in humid conditions that are per-excellent ... |
41809555 | Dynamic covalent organic frameworks. | Covalent organic frameworks (COFs) have emerged as one of the most promising classes of crystalline and porous materials as they offer precise control over structural, catalytic, and optical properties <i>via</i> the design of monomers and their connectivity. While most COFs are rigid materials with fixed geometry, por... |
41809545 | Nanotechnology engineering of polyanionic Na<sub>3</sub>V<sub>2</sub>(PO<sub>4</sub>)<sub>2</sub>F<sub>3</sub> cathodes toward high-performance sodium-ion batteries. | Polyanionic Na<sub>3</sub>V<sub>2</sub>(PO<sub>4</sub>)<sub>2</sub>F<sub>3</sub> (NVPF) cathodes enable a high operating voltage for sodium-ion batteries (SIBs) by virtue of the valence-electron decoupling properties from vanadium metal transition-metal redox centers and polyanionic groups. However, the low intrinsic c... |
41809408 | Conjugation-Induced Self-Selective Coordination Enables Organic Polymers with Low-Temperature Ammonium-Ion Storage. | Aqueous ammonium-ion (NH<sub>4</sub> <sup>+</sup>) batteries/capacitors, recognized for inherent high safety and fast diffusion kinetics, are a promising alternative for sustainable energy storage. However, the development of ammonium-ion energy storage devices has been hindered by the poor compatibility between the di... |
41809085 | A review on multifunctional applications of MgO nanostructures: from material science to environmental and agricultural innovations. | Green synthesis of magnesium oxide nanoparticles (MgO NPs) using plant extracts and bio-waste materials represents a sustainable alternative to conventional synthesis methods. MgO, characterized by its crystalline lattice of Mg<sup>2+</sup> and O<sup>2-</sup> ions, exhibits hygroscopic properties and is a white, solid ... |
41809084 | A large-scale and flexible SERS substrate based on sliver decorated nano-cone arrays and its applications for pesticide residue detection. | This paper demonstrates a large-scale, flexible SERS substrate (Ag@R-SERS substrate) based on silver-decorated nano-cone arrays. The substrate was fabricated <i>via</i> a two-step process: pre-designed nano-cone arrays were replicated over a large area with high structural uniformity using roll-to-roll ultraviolet nano... |
41809082 | Advances in NP shapes and their applications in cancer therapy. | Cancer is a major global cause of death, yet traditional treatments such as surgery, chemotherapy, and radiotherapy have inherent limitations. Nanoparticles (NPs) are rapidly emerging as drug delivery systems for cancer treatments, offering promising advancements to overcome associated challenges and enhance therapies.... |
41809079 | Environmentally friendly fluorescence platform for detection of tetracycline in pharmaceutical formulations and human serums based on highly fluorescent 1,4-di-2-(5-phenyloxazolyl)-benzene. | Tetracycline (TC) is an efficient antibiotic used for curing different bacterial infections in both humans and animals. Accurate and precise detection of TC is a requisite for quality control of pharmaceutical productions and patient safety using a reliable method. This study presents a highly sensitive and selective s... |
41809077 | Solvent-mediated organocatalytic browning of biogenic indoles enables the formation of zwitterionic nanoparticles. | Solvent-mediated browning has recently emerged as a distinctive mode of chemical transformation in solution-phase chemistry. In this study, we extend this concept to biogenic indoles and show that an organocatalytic browning process can be achieved in a mixed DMSO/acetone system under mild, catalyst-free conditions. Tr... |
41809076 | MOF-derived MoO<sub>2</sub>/C composites as high-performance electrodes for electrochemical uranium(vi) removal. | In this study, an octahedral MoO<sub>2</sub>/C composite was synthesized by calcining a molybdenum-based metal-organic framework (MOF) precursor. This unique octahedral architecture significantly enhances the electro-adsorption performance while ensuring excellent structural stability. The optimized material exhibited ... |
41807918 | Treatment of copper-electroplating wastewater by UiO-66-Keratin functionalized PES ultrafiltration membrane. | The removal of copper ions from electroplating wastewater has been researched in recent decades including membrane filtration. However, high performance membrane process with lower operating cost is still needed. In this study, a new strategy was developed using an ultrafiltration membrane modified with UiO-66-Keratin ... |
41806890 | From random to chemoselective cross-linking: Reorientation and enhancement of immobilized cross-linked enzyme aggregates of cyclodextrin glucanotransferase from Shouchella lehensis G1 via targeted domain modification. | Uncontrolled, random cross-linking near the enzyme's active site may impede mass transfer and overall activity, which is one of the challenges in cross-linked enzyme aggregates (CLEAs) immobilization. Likewise, a thorough understanding of intermolecular interactions between cross-linkers and enzymes is crucial to yield... |
41804095 | Visible-Light-Regulated Supramolecular Dendritic Organogels Based on Halogen Bonding. | Photoresponsive supramolecular gels have garnered significant research interest owing to their wide-ranging applications. However, most existing systems rely on UV light irradiation, which poses potential health risks and environmental concerns. The halogen bond, characterized by its high directionality, tunable intera... |
41804051 | Non-Invasive Brain Delivery of G4 70/30 PAMAM Dendrimers via the Intranasal Route. | Effective treatment of neurological disorders remains a major clinical challenge due to the restrictive nature of the blood-brain barrier (BBB), which limits the entry of most therapeutic agents into the central nervous system (CNS). In this study, we investigated the in vivo biodistribution, safety, and CNS targeting ... |
41804024 | Highly Conductive Ag Flakes-Based Bio-Adhesive for Multi-Functional Epidermal Electronics. | Robust skin-electronic interfaces are essential for signal fidelity of wearable bioelectronics, particularly under dynamic physiological conditions. In situ fabrication of biocompatible electronics offers a promising strategy to achieve conformal skin-electronic integration through intimate interfacial contact. However... |
41803913 | Dual tumor microenvironment-responsive albumin nanoplatform integrates conditional PROTAC activation with starvation and ferroptosis for synergistic cancer therapy. | <h4>Background</h4>Proteolysis-targeting chimeras (PROTACs) have emerged as a promising cancer therapeutic approach by targeting protein degradation to address undruggable targets and drug resistance associated with conventional therapies, yet their clinical translation is hindered by poor solubility and non-specific t... |
41803904 | Evaluating the effect of immunization with DNA encoding Phlebotomus sergenti apyrase protein (PsSP42) against Leishmania tropica infection in BALB/c mouse model. | <h4>Background</h4>Leishmania parasites are transmitted through the bite of infected female sand flies. The sand fly inoculum contains both the parasite and the salivary proteins, which can modulate the immune system's function. Some of these salivary proteins have the potential to be used as a vaccine candidate. Since... |
41803870 | Based on the gut-heart axis: Polygonum capitatum improves atherosclerosis by modulating gut microbiota and TMAO, supporting MCPIP1/p53-associated endothelial protection. | Polygonum capitatum (PC), known as "Tou Hua Liao" (Chinese name), is an essential source of Hmong medicinal plants, which has been used for treating various human diseases. This study examined whether PC has lipid-lowering and anti-atherosclerotic effects and explored the underlying mechanisms. We focused on PC's influ... |
41803560 | Dual targeting of topoisomerase I and DNA G-quadruplexes enhances senescence and chemosensitivity in colorectal cancer. | Colorectal cancer (CRC) remains a therapeutic challenge due to chemoresistance that limits conventional treatment efficacy. We developed ZBH-01, a camptothecin derivative engineered to target both topoisomerase I (TOP1) and DNA G-quadruplexes (G4s). Unlike irinotecan (CPT-11), which requires metabolic activation, ZBH-0... |
41803439 | Scaffolds with optimized quaternary symmetry for de novo cryoEM structure determination of small RNAs. | Structured RNAs play many roles in cells and emerging biotechnology. While large RNAs and ribonucleoprotein complexes often benefit from high-resolution structural analysis through cryogenic-sample electron microscopy (cryoEM), single-domain RNAs, particularly those smaller than ~100 nt (33 kDa), have proven challengin... |
41803432 | Computational evaluation of aluminum and zinc doped C<sub>20</sub> fullerenes as advanced sensors for the detection of the narcotic dimethyltryptamine. | N, N-Dimethyltryptamine (N, N-DMT) is a potent psychedelic substance whose detection is crucial in medical and forensic contexts. In this study, we computationally evaluate the potential of aluminum- and zinc-doped C<sub>20</sub> fullerenes (AlC<sub>19</sub> and ZnC<sub>19</sub>) as advanced sensors for N, N-DMT detect... |
41803230 | Glycan-binding properties of SARS-CoV-2 spike proteins: interactions with aminoglycoside antibiotics. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells via its spike (S) protein, which binds to the angiotensin-converting enzyme 2 (ACE2) receptor. Glycans are thought to influence this interaction by modulating the binding affinity between the S protein and its receptor. In this study, we sc... |
41803159 | Molecular mapping in DNA-PAINT via modified Gaussian Mixture Modeling. | Super-resolution fluorescence microscopy, and specifically DNA-PAINT, provides localization precision down to ~2 nm enabling molecular-resolution imaging. To produce molecular maps of single biomolecules, their positions must be inferred from localizations stemming from single fluorescent molecules. Current clustering ... |
41803143 | Amphotericin B promotes respiratory viral entry by enhancing late endosomal maturation and fusion via glucocerebrosidase-mediated ceramide remodeling. | Respiratory viral infections, such as influenza and COVID-19, pose significant global health challenges. For patients with invasive pulmonary aspergillosis, a subsequent viral infection can lead to markedly worse clinical outcomes. Although amphotericin B (AmB) remains a cornerstone antifungal therapy, our investigatio... |
41803124 | Site-defined Cu-O ensembles enable hydrogen-conserving light-driven ethane upgrading. | Upgrading light alkanes to value-added olefins is a long-standing challenge, owing to the high stability of C-H bonds and the tendency for overoxidation at elevated temperatures. Here, we introduce a light-driven strategy for ethane dehydrogenation using Cu-doped TiO<sub>2</sub>, in which atomically dispersed Cu coordi... |
41803113 | Bioengineered ferritin-based lysosome-targeting chimera platform for tumor-targeted therapy. | Lysosome-targeting chimeras (LYTACs) hold therapeutic potential by degrading pathogenesis-associated proteins. However, current LYTAC systems often require considerable effort for case-by-case construction and are devoid of a convenient and efficient modular platform. Here, we develop a modular LYTAC platform based on ... |
41803112 | FLEXTAG: a small and self-renewable protein labeling system for anti-fading multi-color super-resolution imaging. | Super-resolution fluorescence imaging enables visualization of subcellular structures and molecular interactions at the nanoscale, but its broader application has been hindered by long-standing limitations in current protein tagging systems, including rapid photobleaching, tag-induced artifacts, poor post-fixation labe... |
41803084 | Small molecule screening identifies cytotoxic endoplasmic reticulum-associated degradation inhibitors in multiple myeloma. | Multiple myeloma (MM) is an incurable plasma cell neoplasm that is highly reliant on endoplasmic reticulum-associated degradation (ERAD) to maintain protein homeostasis. Disrupting ERAD has been proposed as a therapeutic strategy to overcome proteasome inhibitor resistance; however, the identification of novel inhibito... |
41803050 | Synthesis of Confined HPW@ZIF-8 for Ambient Catalytic Oxidation of Aromatic Sulfides in Diesel. | The catalytic oxidation of aromatic sulfides under mild, ambient conditions facilitates the high-value utilization of diesel fuel, free from external heating sources. Herein, a high-performance confined catalyst through a simple one-pot method is developed, denoted as HPW@ZIF-8. The phosphotungstic acid is encapsulated... |
41803036 | Low-Dimensional MOF Nanoarchitectonics: Progress in MOF-2D Material Hybrid Architectures for Energy Conversion and Storage. | The integration of metal-organic frameworks (MOFs) and two-dimensional (2D) materials is a powerful and rapidly advancing strategy for creating multifunctional hybrid materials. Unlocking their full potential requires overcoming the intrinsic limitations of each component, specifically the poor electrical conductivity ... |
41803022 | An unconventional three-domain odorant-binding protein decodes contrasting host pheromones in the parasitoid wasp Anastatus japonicus. | Invasive insect pests threaten global food security, necessitating sustainable management strategies beyond chemical pesticides. Biological control agents such as egg parasitoids are promising alternatives, yet the molecular basis of their host-seeking behavior is poorly understood. Odorant-binding proteins (OBPs) are ... |
41803014 | Desferrioxamine Sharing among Microalgae-Associated Bacteria Enhances Iron-Limited Inhibition of <i>Vibrio anguillarum</i>. | <i>Vibrio anguillarum</i> remains a major problem in marine aquaculture, motivating the search for ecologically grounded microbial strategies for pathogen control. We previously showed that a coculture of <i>Vreelandella alkaliphila</i> D2 and <i>Sulfitobacter pontiacus</i> D3, isolated from <i>Isochrysis galbana</i>, ... |
41803011 | Fe<sup>3+</sup>-Mediated Blue Pigment Formation via Collaborative Regulation of Iron Homeostasis by VIT1 and Ferritin: Insights for Blue Flower Breeding. | The bright blue colouration of Centaurea cyanus (cornflower) is attributed to a supramolecular pigment formed via metal ion chelation with accumulated cyanidin (Cy) and co-pigments, yet the underlying genetic regulatory mechanisms remain incompletely understood. Elucidating this mechanism will facilitate the molecular ... |
41802796 | Osteoporosis treatment gap and prescribing patterns in Ireland: a cross-sectional analysis of the DXA HIP project. | <h4>Objectives</h4>Previous studies suggest Ireland has the smallest osteoporosis treatment in Europe and very little inappropriate prescribing, in contrast to our experience. In this study, we examine the osteoporosis treatment gap in Ireland by assessing the prevalence of appropriate and inappropriate prescribing in ... |
41802435 | [The Scientific Usage of GPS Data in Professional Football: Relevance, Norm Values and Practical Recommendations]. | The use of GPS data has become an integral part of the work of strength and conditioning coaches as well as data analysts in professional women's and men's football. Coaches should rely on GPS systems with a comparatively high sampling frequency (18 Hz) in order to validly capture short sprint distances with rapid chan... |
41802275 | Excitation Energy Transfer in an Intermediate Regime: A Multiconfigurational Gaussian Wavepacket Study of a Light-Harvesting Supramolecular Dyad. | Ultrafast excitation energy transfer (EET) is studied for a supramolecular rhodamine-BODIPY dyad, which exemplifies EET systems that fall into a non-Förster regime where coherent effects are important. A key question that arises concerns the transition between coherent and kinetic transfer regimes, which is addressed h... |
41802224 | Automated Force Field Developer and Optimizer Platform: Torsion Reparameterization. | General force fields such as General Amber Force Field (GAFF) have been designed for broad applicability and are widely used in protein-ligand binding simulations in structure-based drug discovery. However, the force field parameters are not always transferable across ligand molecules, and custom reparameterization is ... |
41802179 | Functional Nano-to-Microstructures by Jet Printing and Direct Ink Writing. | Jet-based printing techniques and direct ink writing have emerged as complementary, convergent technologies serving as key platforms in additive manufacturing for functional nano- to microscale architectures. This review highlights how these approaches enable fine feature resolution and three-dimensional structures in ... |
41802090 | DNA-Logic Trimodal Biofuel Cell Platform for AI-Assisted Dual Pathogen Detection. | A DNA-logic-gated, trimodal, self-powered biosensing platform is developed for the rapid, simultaneous, and on-site detection of two major sugarcane pathogens, <i>Sporisorium</i> <i>scitamineum</i> (smut) and <i>Fusarium</i> <i>sacchari</i> (pokkah boeng). Conventional diagnostic techniques such as qPCR are considered ... |
41802074 | Hierarchical Self-Assembly of Discrete Metal-Organic Supramolecules with Emergent Properties and Functions. | Hierarchical self-assembly, wherein simple molecular components undergo multiple, ordered organization steps, underlies the construction of complex functional architectures in biological systems and has inspired advances in artificial supramolecular chemistry. In this context, hierarchically assembled metallosupramolec... |
41802073 | Electron Transfer-Enhanced Bimetallic MOF Nanozymes Enabling a Self-Validating Dual-Mode Aptasensor for Aflatoxin B<sub>1</sub>. | Aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) is a widespread mycotoxin that poses a substantial risk to food and health safety due to its potent toxicity and carcinogenic properties. Herein, a novel colorimetric-electrochemical dual-mode aptamer sensor utilizing the MIL-88@Pd/Pt nanozymes has been successfully constructed... |
41802005 | In silico design of novel recombinant antigens containing immunologically relevant regions of wild-type and escape mutant variants of HBsAg. | Hepatitis B virus (HBV) contributes substantially to liver cancer, related mortality, and liver transplantation worldwide. The small hepatitis B surface antigen (HBsAg), particularly its major hydrophilic region (MHR) and the "a" determinant, is the primary target of serological diagnostics. However, escape mutant amin... |
41801976 | Engineering MXenes for Thermal and Photothermal Catalysis. | Heterogeneous catalysis relies on advanced, tunable materials offering structurally defined active sites and large accessible surface areas. Among the various material types, two-dimensional nanomaterials with high aspect ratios feature a high fraction of exposed atoms and thus efficient atom utilization. After more th... |
41801955 | Integrative network pharmacology and machine learning identify potential targets of indole-3-lactic acid in colorectal cancer. | The treatment of colorectal cancer (CRC) remains challenging due to chemotherapy resistance and genetic heterogeneity. Indole-3-lactic acid (ILA), a tryptophan metabolite derived from gut microbiota, exhibits promising anti-inflammatory and anticancer properties; however, its specific molecular targets and regulatory m... |
41801896 | Functionally-derivatized Nanoantibodies as novel tools for Giardia lamblia cyst detection. | Giardia lamblia (syn. intestinalis, duodenalis) is the causative agent of Giardiasis, a diarrheal disease of global medical importance, especially problematic in young children living in unhygienic, resource-constrained settings. Diagnostics of potential Giardia infections are generally done through classic light-micro... |
41801814 | Discovery of Coracanols A and B, Two Biological Nitrification Inhibition Diterpenoids from Finger Millet. | Natural products with biological nitrification inhibition (BNI) activity released from plant roots show potential for increasing the nitrogen-use efficiency and decreasing the extent of environmental pollution. We isolated two diterpenoids, coracanols A (<b>1</b>) and B (<b>2</b>), from finger millet grown under low-ni... |
41801526 | Superiority of Chrysophyllum oliviforme in the green synthesis of highly stable ZnO nanoparticles: metabolomic profiling, quadruple antiviral screening, and comparative MD simulations. | This study presents a comprehensive comparative evaluation of the green synthesis of zinc oxide nanoparticles (ZnO NPs) using alcoholic leaf extracts from Chrysophyllum oliviforme and Chrysophyllum cainito, focusing on their phytochemical-mediated stabilization and broad-spectrum antiviral efficacy. Ultra-performance l... |
41801494 | Formulated Diet Instead of Chilled Fish Is Beneficial to Microbial and Water Quality in Mandarin Fish (Siniperca chuatsi) Ponds. | The Mandarin fish (Siniperca chuatsi) is a valuable carnivorous species that is traditionally farmed alongside chilled fish. This practice often degrades water quality and threatens sustainability. In this study, pond environments under two feeding regimes, including chilled fish (CF) and formulated diet (FD), were com... |
41801129 | [In<sub>3</sub>O]-In Dual-Nodes-Based Metal-Organic Framework as a Self-Calibrating Luminescent Sensor for Rapidly Detecting Sophocarpine. | Detection of sophocarpine, a pharmacologically active alkaloid with a narrow therapeutic window and potential neurotoxicity at elevated concentrations, is critically important in the clinic. In this work, we present an indium-based metal-organic framework {[(CH<sub>3</sub>)<sub>2</sub>(NH<sub>2</sub>)][(In<sub>3</sub>O... |
41801017 | Glycoside hydrolases enhance antibiotic activity against <i>Pseudomonas aeruginosa</i> biofilms from cystic fibrosis airways. | <i>Pseudomonas aeruginosa</i> forms antibiotic-tolerant biofilms in cystic fibrosis (CF) lungs. Targeting exopolysaccharides such as Psl and Pel offers a potential strategy to disrupt biofilms and improve antibiotic efficacy. Fourteen clinical CF <i>P. aeruginosa</i> isolates were screened for Psl- and Pel-dependent bi... |
41800952 | Regioselective Synthesis of Ambipolar B-N Lewis Pair Functionalized Pyrenes: Structural Dynamics, Emission Tuning, and Applications in Live Cell Imaging and as Electrochemiluminescent Materials. | Intramolecular B←N Lewis pair functionalization of polycyclic aromatic hydrocarbons (PAHs) is emerging as a powerful strategy for tailoring their optical and electronic properties to specific applications. Herein, we report the design and synthesis of four quadrupolar pyrene fluorophores containing triarylamine donor a... |
41800927 | Electrochemically Driven Directional Chirality Control for Surface-Confined Pillararenes and Its Application in Enantioselective Recognition. | The precise construction of chiral interfaces with selectively controllable conformations is crucial for enantioselective sensing. This work developed an electrochemical strategy that enables directional fixing of the planar chirality of pillararenes. By applying an oxidation or reduction electrochemical process, the c... |
41800605 | Preclinical advances and mechanistic insights of CAR-T therapy for acute myeloid leukemia: from target iteration to microenvironment regulation. | <h4>Introduction</h4>Relapsed/refractory acute myeloid leukaemia (AML) carries a dismal prognosis, primarily due to profound biological heterogeneity and the scarcity of effective targeted therapies. Chimeric antigen receptor T (CAR-T) cell therapy has emerged as a transformative investigational strategy for AML by gen... |
41800606 | Cuticle-associated microbiota in Bactrocera dorsalis suppress fungal infection through immune and chemical defenses. | <h4>Background</h4>Cuticular microbial communities influence insect-pathogen interactions, yet their protective roles remain incompletely understood. These microbial defenses are critical in pest species like Bactrocera dorsalis, where microbial symbionts may shape resistance to biological control agents.<h4>Results</h... |
41797579 | Helicogenic Amino Acid Increases Passive Permeability and Oral Bioavailability of Macrocycles by Preorganizing γ-Turn. | Macrocyclic peptides (MCPs) are promising drug candidates but often exhibit poor passive membrane permeability due to their polar backbone. This study demonstrates that incorporation of α-aminoisobutyric acid (Aib), a helicogenic residue, can enhance MCP permeability in a scaffold-dependent manner by enforcing γ-turns ... |
41797544 | Mapping the TNFR2-targeting antibody patent landscape: Insights from macro trends to structural signatures. | Pharmacological modulation of TNFR2 function has emerged as an effective strategy for modulating immune responses in cancer and inflammatory diseases. Both academic and industrial efforts have pursued therapeutic approaches targeting TNFR2, leading to a substantial accumulation of patents. Beyond documenting translatio... |
41797478 | Prussian Blue Nanozyme Disrupts the Self-Reinforcing Loop of Tauopathy via Triple-Action Mechanism. | Tauopathies, such as Alzheimer's disease, are driven by a self-reinforcing pathological triad of tau aggregation, oxidative stress, and autophagy dysfunction, which remains inadequately addressed by single-target therapies. Herein, we engineer an ultrasmall Prussian blue nanozyme (PBzyme) as a multienzyme-mimetic and m... |
41797477 | Water-Cluster-Mediated Amorphous-to-Crystalline Transition Enables Scalable Fabrication of Stable Surfactant-Free MOF Nanocatalyst. | Metal-organic framework (MOF) nanocatalysts are promising for solar-to-chemical conversion but often suffer hydrolytic degradation, especially in surfactant-free, highly surface-active forms. Here, we report a dual-functional design that integrates amorphous nanostructuring with water-triggered self-coordinated crystal... |
41796402 | Extraordinary diversity of antiviral immune-related gene families across 38 bat species. | <h4>Background</h4>Despite harboring diverse pathogenic viruses, bats rarely exhibit clinical symptoms of the diseases. Previous research has reported evolutionary characteristics in key antiviral gene families in bats, such as natural killer cell receptors, MHC class I genes, and type I interferons, suggesting that ba... |
41796144 | Electrochemically optimized multi-component polyacrylonitrile nanofiber scaffolds as a platform for three-dimensional glioblastoma cell culture. | Glioblastoma multiforme represents the most aggressive primary brain malignancy with limited treatment options. Current research critically lacks three-dimensional culture platforms that can both recapitulate native tumor microenvironments and enable quantitative monitoring of cellular behavior. This study presents the... |
41796123 | Deterministic quantum light emitters in DNA origami-engineered molecule-MoS₂ hybrids. | The functionalization of atomically-thin transition metal dichalcogenides (TMDs) with organic molecules is a promising approach for realizing nanoscale optoelectronic devices with tailored functionalities, such as quantum light generation or p-n junctions. However, achieving precise control over the molecules' position... |
41697225 | Radical enzymatic peptide cyclization in natural product biosynthesis. | Cyclic peptides are privileged scaffolds in natural product biosynthesis and drug discovery, valued for their structural diversity, metabolic stability, and potent biological activities. Radical-mediated enzymatic cyclization has emerged as a powerful biosynthetic strategy for constructing structurally complex and bioa... |
41439345 | Selective spontaneous reaction of flavonoids in CD-MOF-1. | Developing artificial reactors for the synthesis of peroxy (O-O) bonds offers a new route to the creation of flexible intermediate platforms. Herein, we report a selective spontaneous reaction of flavonoid with γ-cyclodextrin (γ-CD) in cyclodextrin metal-organic framework (CD-MOF-1). Remarkably, simple incubation of fl... |
41404643 | Dendrimers with a far-red NDI fluorescent core for efficient and traceable gene and RNA delivery. | Dendrimer-based nucleic acid (NA) delivery systems have attracted significant attention due to their synthetic versatility, monodispersity, nuclease resistance, high payload release, and transfection efficiency. The conventional dendrimers are non-fluorescent, limiting their utility in real-time tracking and monitoring... |
41959883 | Twin-compartment solid-liquid cells for neutron reflectometry. | We propose a new type of sample environment for neutron reflectometry at solid-liquid interfaces. The twin-compartment solid-liquid cell optimizes several aspects of neutron reflectometry measurements by splitting the surface of substrates currently in use at facilities into two independent samples. This approach incre... |
41902240 | First Molecular Characterization and Comprehensive Bioinformatic Analysis of Avian Infectious Bronchitis Virus from Uzbekistan Reveals GI-1, GI-13, and GI-23 Genotypes in Broilers. | Avian Infectious Bronchitis Virus (IBV) is a highly contagious Gammacoronavirus that poses a significant threat to the global poultry industry. Despite its worldwide prevalence, a critical knowledge gap exists regarding the genetic diversity of IBV in Central Asia, particularly in Uzbekistan. This study is the first co... |
41900821 | Graphene-Based 3D Scaffolds in Bone Regeneration: Emerging Opportunities for MRONJ Treatment. | <b>Background</b>: Medication-related osteonecrosis of the jaw (MRONJ) remains a challenging complication associated with antiresorptive and antiangiogenic therapies, characterized by impaired bone healing, infection, and compromised vascularization. Advanced biomaterials capable of promoting bone regeneration and modu... |
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