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41855800 | Integrated network pharmacology and in vivo validation reveal the action of Scutellaria baicalensis extract against oviductal inflammation in laying hens. | Oviductal inflammation in laying hens presents a significant challenge to the laying hen industry, leading to a significant decline in production performance and eggshell quality. The supplementation of traditional Chinese herbs or their extracts has been proven to be beneficial for improving the growth performance and... |
41847560 | Dual-engineering metalloimmunotherapy mediates <i>Staphylococcus aureus</i> virulence silencing and biofilm immune microenvironment reprogramming against implant-associated infections. | Implant-associated infections (IAIs) caused by <i>Staphylococcus aureus</i> (<i>S. aureus</i>) are notoriously recalcitrant to treatment due to the self-reinforcing interplay between bacterial virulence and a suppressive biofilm immune microenvironment (BIME). Here, we present a dual-engineering metalloimmunotherapy na... |
41847377 | Isothermal-microwave pretreatment enhances the quality and oxidative stability of cold-pressed oil from short-term germinated sesame seeds. | Enhancing the oxidative stability of cold-pressed sesame oil using green methods without high-temperature treatments remains challenging. Short-term germination is a common but limited solution. In this study, isothermal-microwave pretreatment (80 °C, 0-60 min) was applied to short-term germinated sesame seeds, followe... |
41828704 | Biophysical Modeling of Lipopolysaccharides in Gram-Negative Bacteria: From Atomic to Colloidal Models. | Lipopolysaccharides (LPSs) are key components of the bacterial outer envelope, determining its structural integrity, barrier properties, and interactions with the surrounding environment. This review analyzes the relationship between the molecular architecture of LPSs and their physicochemical properties. Particular at... |
41828700 | Virtual Screening of Marine Natural Products Targeting the F Protein for Anti-RSV Drug Discovery. | Respiratory syncytial virus (RSV) poses a substantial global health burden, particularly in infants and the elderly. The fusion (F) protein is a key therapeutic target for inhibiting RSV entry. In this study, we performed a structure-based virtual screening of the Comprehensive Marine Natural Products Database (CMNPD) ... |
41810047 | Remodeling the Inflammatory Microenvironment: Nanomaterial-Based Targeted Strategies for Systemic Lupus Erythematosus and Lupus Nephritis. | Systemic Lupus Erythematosus (SLE) is a complex autoimmune disorder, with Lupus Nephritis (LN) representing a severe complication that affects a significant proportion of patients. Current treatments, including corticosteroids and immunosuppressants, are limited by systemic toxicity and nonspecific biodistribution. Nan... |
41809495 | Advanced Spectroscopic, Imaging, and Nanotechnology Tools for Diagnosing Fungal Diseases in Fruits. | Fruits are a critical component of the human diet, as they provide essential dietary nutrients that play an important role in the functioning of the human body and maintaining health. It is well-known that consuming fruits has various benefits, including the prevention of chronic diseases, cancer, and cardiovascular di... |
41808688 | Photoactivation in Chemotherapeutic Compounds for Cancer Treatment: Opportunities Beyond Photodynamic Therapy. | Photoactivation is the stimulation or regulation of a chemical or a chemical process by utilizing light of specific wavelength that corresponds to an absorbance optimum of the agent being used and can penetrate into tissues. In cancer therapy, photoactivatable drugs utilize this phenomenon by allowing the temporal and ... |
41806891 | Preparation of V-type granular starch in natural deep eutectic solvent and its physicochemical properties and in vitro digestibility. | To address stringent operating conditions and reagent toxicity in conventional preparation methods, a new methodology employing natural deep eutectic solvent (choline chloride/malic acid) as media was developed to produce V-type granular starch. Analyses were conducted on the structure, hydration characteristics and in... |
41797395 | Lateral Boron-Doping Intensifies Diradical State and Stabilizes Spins of <i>peri</i>-Acenoacene: A Nanographene Diradicaloid with Absorption beyond 1300 nm. | Control over topological structures is important for achieving desirable electronic structures of polycyclic aromatic hydrocarbons (PAHs). Especially the zigzag edge topology may induce spin-polarized edge states that are useful for spintronics and quantum devices but simultaneously enhances intrinsic instability in te... |
41797001 | NAStructuralDB : structural database to facilitate computational studies of molecular modeling and recognition of proteins with special focus on antibody-antigen interactions. | Studying the interactions between antibodies and antigens is fundamental to the development of novel therapeutic biologics. Predictions of such interactions start with data collection. Though there exist reliable resources to identify antibody structures in the Protein Data Bank (PDB), such data still requires substant... |
41796385 | In vitro and in silico characterization of Crocatin A from red betel leaves: targeting DNA gyrase B and DNA ligase of Enterococcus faecalis with ADMET-based druglikeness analysis. | Dental caries is a disease of tooth tissue that can lead to complications, with Enterococcus faecalis being one of the Gram-positive bacteria that plays a crucial role in the infection process. Red betel leaves (Piper crocatum Ruiz & Pav.) are known to contain various phytochemicals; however, the antibacterial potentia... |
41796358 | Microneedle-based delivery of cell membrane vesicles as IL-17RA decoys for Psoriasis treatment. | The dysregulation of IL-17/IL-17 receptor A (IL-17RA) signaling axis is a central driver of multiple autoimmune diseases. In contrast to targeting individual IL-17 cytokines, blocking IL-17RA simultaneously inhibits the receptor engagement of multiple IL-17 ligands, thereby effectively suppressing downstream pathway ac... |
41796309 | Multifunctional copper-based nanoparticles potentiate colorectal cancer immunotherapy via synergistic metabolic remodeling and cGAS-STING pathway activation. | Microsatellite-stable (MSS) colorectal cancer (CRC) resists immunotherapy due to its immunosuppressive tumor microenvironment (TME). The cGAS-STING pathway, a key regulator of innate immunity, offers a promising strategy to overcome the immunotherapy resistance in CRC. However, its limited endogenous activation, couple... |
41796047 | Study on simultaneous short-cut nitrification-denitrification for nitrogen removal in wastewater with low C/N ratio. | This study employed a single-stage aerobic sequencing batch reactor (SBR) to establish a simultaneous short-cut nitrification-denitrification (SSND) system, addressing the denitrification challenges in wastewater with low carbon-to-nitrogen (C/N) ratios. By controlling low dissolved oxygen (DO, 0.3-0.5 mg/L) and employ... |
41796041 | Enhanced preservation effects of clove essential oil-loaded chitosan/beta cyclodextrin metal organic frameworks (β-CD-MOFs) composite coating on cherry tomatoes. | <h4>Background</h4>Cherry tomatoes are prone to postharvest deterioration and spoilage at room temperature, whereas chemical preservatives pose safety and environmental risks. Clove essential oil (CEO) has excellent antibacterial activity but is limited by high volatility, poor water solubility and dosage sensitivity. ... |
41795072 | Ferroptosis-driven in situ vaccine-like antitumor effects: NIR-triggered IFBM hydrogel synergizes with sorafenib to unleash systemic antitumor immunity. | The immunosuppressive tumor microenvironment and immune evasion mechanisms inhibit the development of effective antitumor responses and enduring immune memory, thereby diminishing the efficacy of cancer immunotherapy. In situ vaccines (ISVs) have been developed to overcome these challenges by inducing localized immunog... |
41795043 | Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target. | Ferroptosis, a regulated cell death modality driven by iron accumulation and lipid peroxidation, has emerged as a pivotal pathophysiological mechanism across a broad spectrum of cardiovascular diseases (CVDs), which remain the leading cause of global mortality. Although robust preclinical evidence indicates that modula... |
41794753 | Engineered lipid hybrid nanoparticles for targeted delivery of SH2 superbinder and breast cancer therapy. | SH2 Superbinder (SH2S) is an engineered polypeptide tool derived from the SH2 domain. It exhibits significantly enhanced binding capacity for tyrosine-phosphorylated proteins to treat various cancers. However, its clinical application is limited by poor serum stability and insufficient tumor targeting. To solve these p... |
42006566 | Effect of Polymer Structure on the Thermodynamics of Polyelectrolyte Complex Micelle Formation. | Polyelectrolyte complex micelles (PCMs) are nanoparticles that form through the associative phase separation between hydrophilic neutral-charged block copolymers and oppositely charged polyelectrolytes, resulting in a dense, charged core surrounded by a stabilizing neutral corona. Among other applications, these constr... |
41923987 | Corrigendum to "Brinzolamide encapsulated β-cyclodextrin-chondroitin sulfate nanocomplexes anchored chitosan/polycaprolactone nanofibers as an ocular insert for glaucoma treatment" [Mater. Today Bio <b>34</b> (2025) 102179]. | [This corrects the article DOI: 10.1016/j.mtbio.2025.102179.]. |
41918759 | Nanostructured ZIF-67/LaFeO<sub>3</sub> p-n heterojunction interface for amplified cefotaxime sensing & intensified photo-Fenton degradation. | The efficient removal and detection of antibiotic contaminants without generating hazardous byproducts remain critical challenges in environmental chemistry. Herein, a ZIF-67/LaFeO<sub>3</sub> nanocomposite with a high specific surface area (1082.94 m<sup>2</sup> g<sup>-1</sup>) is constructed to function as a dual mod... |
41908409 | Flower-Like CNTs@MoS<sub>2</sub> Core-Shell Nanostructure for NH<sub>3</sub> Gas Sensor at Room Temperature. | Ammonia (NH<sub>3</sub>) is a hazardous gas requiring rapid detection at room temperature for practical environmental and agricultural monitoring. Herein, we report a flower-like CNTs@MoS<sub>2</sub> core-shell heterostructure synthesized via a facile hydrothermal process for room-temperature NH<sub>3</sub> sensing. St... |
41907438 | Enhanced cell contact and planarian tissue extract increase DNA replication and viability for neoblast cultivation. | The development of an <i>in vitro</i> culture system for planarian neoblasts remains at an early stage. Although modified neoblast enrichment method and basic culture conditions have been established, it is unclear which micro- and macro-environments can functionally improve neoblast behavior <i>in vitro</i>. Neoblasts... |
41907433 | Physical crowding in 3D niche regulates neural stem cell differentiation via Cx43-mediated gap junction communication. | Neural stem cells (NSCs) maintain central nervous system (CNS) homeostasis through self-renewal and differentiation into neurons and glia. Although physical crowding shapes the NSC niche during CNS development, its role in fate determination remains poorly understood. We investigated how NSC crowding influences interce... |
41895946 | Castor oil-based waterborne polyurethane photodynamic antimicrobial films: Preparation and strawberry preservation application. | This study synthesized anionic castor oil-based waterborne polyurethane (WPU) and cationic quaternized cellulose nanofiber (CCNF), and encapsulated curcumin (Cur) with hydroxypropyl-β-cyclodextrin (HP-β-CD) to form a Cur inclusion complex (CD). CD/CCNF/WPU composite films with water resistance and photodynamic antimicr... |
41893124 | Computational Modeling of Cellulose Synthase Heterotrimer Assembly and Identification of Antimicrobial Compounds Targeting Interface Sites in <i>Phytophthora infestans</i>. | <i>Phytophthora infestans</i>, a devastating oomycete pathogen responsible for late blight in solanaceous crops, relies on cellulose synthase (CesA) complexes for cell wall biosynthesis and virulence. Unlike plant CesAs that form homomeric trimers, oomycete CesA complexes are hypothesized to assemble as heteromeric uni... |
41853608 | Magnetic fluorine-functionalized covalent organic framework coupled with ambient mass spectrometry for rapid determination of benzoylurea insecticides in fruits and vegetables. | Establishing a convenient and sensitive method for the enrichment and analysis of benzoylurea insecticides (BUs) in fruits and vegetables is essential for food safety monitoring. To this end, a novel fluorine-rich magnetic covalent organic framework (Fe<sub>3</sub>O<sub>4</sub>@COF-F) was designed and synthesized as an... |
41829217 | Class-Specific Immunochromatographic Assay Enabled by Mesoporous Nanozyme-Catalyzed Signal Amplification for On-Site Screening of Sulfonylureas. | Conventional immunochromatographic assays (ICAs) face limitations in sensitivity and dynamic range, hindering their application in on-site, class-specific screening of sulfonylurea (SU) adulteration in functional foods. To address this, a signal amplification strategy was developed by engineering high-density platinum ... |
41829210 | Nanosuspensions Loaded with Acetogenins: Physical Stability During In Vitro Digestion, Genotoxicity and Cytotoxicity. | This study assesses the stability, in vitro bioaccessibility and potential bioavailability, and in vivo genotoxicity and toxicity of polyethylene glycol-soy lecithin (PEGSL-ACG-NSps) or β-cyclodextrin-soy lecithin (βCDSL-ACG-NSps) nanosuspensions (NSps). Both formulations exhibited initial particle sizes below 130 nm a... |
41825389 | Decoding the new dimensions of leucodelphinidin as a dual antioxidant and anti-diabetic candidate: A DFT, docking and dynamics evaluation. | Leucodelphinidin (LDN) is an underrated flavonoid with dual roles as a potent antioxidant and anti-diabetic agent. This study evaluates its radical scavenging ability using density functional theory (DFT) across multiple antioxidant pathways. This includes hydrogen atom transfer (HAT), sequential electron transfer-prot... |
41822852 | Advances in Nanotechnology for Lymphoma Treatment: Targeted Delivery, Immunomodulation, and TME-Responsive Therapy Strategies. | Lymphoma is a heterogeneous malignant proliferative disease of lymphocytes, with characteristics of liquid tumor and solid tumor. With the emergence of targeted drugs, monoclonal antibodies, bispecific antibodies, antibody-drug conjugates, and CAR-T therapy, the treatment landscape for lymphoma has been transformed. Ho... |
41818876 | Synergistic bimetallic enhancement in sulfur-doped spinel oxide cathodes derived from metal organic frameworks for direct borohydride-hydrogen peroxide fuel cells. | The creation of extremely effective catalysts for the hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) reduction reaction (HPRR) is still a crucial problem influencing performance advancements in fuel cell systems with H<sub>2</sub>O<sub>2</sub> as the cathodic oxidant. This study employs a hydrothermal method coupled wi... |
41806732 | A dual-mode sensing platform for the detection of glucose based on the Au NPs@Fe-MOF with dual enzyme activity. | Increasing evidence links high sugar intake to health issues, highlighting the need for effective glucose sensors in commercial beverages. Here, a dual-ligand metal-organic framework (Fe-MOF) with both electrochemiluminescence (ECL) and peroxidase-like activities was designed, and an enzyme-free glucose sensor was deve... |
41802673 | Workflows for stable cell line generation: Chemical transfection and viral transduction. | Stable mammalian cell lines with sustained transgene expression are indispensable for functional genomics and long-term genetic studies. However, transient approaches often suffer from inconsistent efficiency and expression instability across diverse cell types. This MiniResource addresses these challenges by providing... |
41802522 | Facile preparation of dual pH/thermo-responsive MOF@chitosan hydrogel microspheres through reactive spray drying for sustained curcumin release and enhanced hemostasis. | In this study, a temperature and pH-sensitive hydrogel microsphere based on metal-organic frameworks (MOFs) and chitosan was successfully prepared through a simple and scalable reactive spray drying technology. Specifically, chitosan quaternary ammonium salt (HACC) and metal organic framework NH₂-MIL-53 were selected a... |
41795000 | Rationally and in silico guided APOBEC3F-directed CBE for enhanced PDAC genetic therapy. | Cytosine base editors (CBEs) mediate precise C-to-T conversion and hold considerable therapeutic promise, yet their editing function and utility in oncology remain underexplored. Here, we integrate evolutionary scale modeling (ESM) with structure-guided mutagenesis to remodel human APOBEC3F (A3F), yielding a panel of h... |
41794994 | Improving foaming properties of fish gelatin by neutral protease and gum arabic. | Neutral protease and gum arabic (GA) were combined to enhance foaming ability (FA) and foaming stability (FS) of fish gelatin. Meanwhile, structural changes of pure, single-modified and combined-modified fish gelatins were evaluated in detail to investigate the mechanism. FA and FS of combined-modified fish gelatin wer... |
41794931 | A scalable and quantum-accurate foundation model for biomolecular force fields via linearly tensorized quadrangle attention. | Accurate atomistic biomolecular simulations are vital for understanding disease mechanisms and drug discovery, yet existing methods struggle to balance quantum-mechanical accuracy with computational scalability. Classical force fields often lack precision, while quantum methods are computationally prohibitive for compl... |
41794923 | Mapping partial agonism of mitragynine at the µ-opioid receptor through molecular dynamics and Markov state modelling analysis. | Mitragynine, a major indole alkaloid from Mitragyna speciosa (kratom), acts as a partial agonist at the µ-opioid receptor (µOR), yet the structural basis for its submaximal efficacy remains unclear. Here, we integrate microsecond-scale all-atom molecular dynamics (MD) simulations with Markov State Modelling (MSM) to pr... |
41794915 | Ligand engineering tailors hydrophobic microenvironments for efficient electrocatalytic oxidation of fatty alcohol. | The intrinsically low solubility of fatty alcohols in aqueous electrolytes imposes critical mass transport limitations for electrocatalytic oxidation. Conventional anodic electrocatalysts typically suffer from poor activity along with severe oxygen evolution reaction due to their hydrophilicity. Here, we present a liga... |
41794866 | Cyclophilin A stabilizes the capsid protein p72 to facilitate African swine fever virus replication. | African swine fever virus (ASFV) is a large DNA virus that poses a major threat to the global swine industry. Its virion is encapsulated by an icosahedral capsid predominantly composed of the structural protein p72, which constitutes approximately one-third of the total virion mass. Despite its abundance, the mechanism... |
41794842 | Coupling programmable shape morphing and solvent-fueled propulsion in a soft bicontinuous composite. | Natural organisms often couple reversible shape reconfiguration and autonomous motion to adapt and respond to dynamic environments. However, synthetic soft materials rarely achieve both behaviors within a single platform due to fundamental trade-offs in structural anisotropy, solvent compatibility, and actuation revers... |
41794808 | Accelerated discovery of highly active enzyme nanohybrids with parallelized Bayesian optimization in hybrid space. | Artificial intelligence (AI) has significantly advanced protein engineering, enabling rapid enzyme evolution for diverse applications. However, the fragile nature of biomacromolecules requires enzyme immobilization to preserve catalytic activity under harsh industrial conditions, which often restricts substrate diffusi... |
41794804 | Cryo-ET comparison of the hierarchical ultrastructure of silkworm, spider, and artificial silk fibers. | Spider and silkworm silks are renowned for their exceptional mechanical properties, which arises from their ultrastructural organization. However, this architecture remains incompletely understood. Here, we apply cryo-electron tomography to examine the hierarchical organization of silkworm, spider, and artificial silks... |
41794802 | Dynamic bond-driven encapsulation of enzymes in metal-organic frameworks beyond pore size constraints. | Immobilizing enzymes in a metal-organic framework (MOF) is an effective approach to improve their stability and reusability, but the small pore sizes of most MOFs exclude many industrially relevant enzymes. Here, we present a dynamic bond-mediated approach that enables enzyme encapsulation beyond pore size constraints.... |
41794715 | Fluoroalkylated antimicrobial peptides enables cytosolic delivery and eradication of intracellular Staphylococcus aureus. | Intracellular bacteria survive are difficult to eradicate by conventional antibiotics. Antimicrobial peptides (AMPs) have garnered increasing attention due to their ability to exert broad-spectrum antibacterial effects through various mechanisms. However, they are also unable to effectively penetrate cell membranes to ... |
41794698 | Multifunctional nanoplatforms deciphering immune resistance in bone tumors: cooperative delivery, immune reprogramming and microenvironment remodeling. | Bone tumors, encompassing primary sarcomas such as osteosarcoma and secondary skeletal metastases from carcinomas, present a stubborn clinical problem. Their treatment is hampered by three interconnected barriers: the physical impediment of a mineralized matrix that restricts drug access, a profoundly immunosuppressive... |
41794547 | Recent advances in genetic control of fiber length in upland cotton. | Cotton fiber quality-defined by length, strength, and fineness-directly influences the commercial value of textile products, with fiber length being one of the most critical parameters in industrial procurement. In upland cotton (Gossypium hirsutum), fiber development occurs through four overlapping stages, of which th... |
41793777 | Navigating the potential of algal peptides: health effects, market applications, and scientific challenges. | <h4>Introduction</h4>Algae-derived bioactive peptides are gaining recognition as functional ingredients offering health benefits and sustainability advantages over conventional proteins. This review aimed to evaluate the current evidence on algal peptides, focusing on their nutritional content, mechanistic actions, hea... |
41793717 | Optically Controlled Peptide-Based Reconfigurable Folding via Regular Monodisperse Azobenzene Arrangement. | Reconfigurable nanostructures featuring geometric deformation present a viable alternative to the canonical disintegration-reassembly paradigm in nanotechnology, however, their implementation in peptide-based supramolecular nanosystems remains challenging. This difficulty stems from a fundamental conflict between struc... |
41793573 | Protein Nanocages as Versatile Vectors for Nucleic Acid Delivery: Main Systems and Their Loading Mechanisms. | The rapid advancement of nucleic acid-based technologies, such as mRNA vaccines and CRISPR-based gene editing, has transformed modern medicine. Yet, their full therapeutic potential remains constrained by the need for precise cargo loading and efficient delivery. This limitation has inspired the development of novel ve... |
41793571 | Fabrication of a 3D nano-bienzyme cascade reactor based on a Dps protein scaffold for chiral amine synthesis. | Based on the self-assembling properties of the SpyCatcher/SpyTag system and the structural advantages of Dps protein, this study successfully constructed a three-dimensional nano-enzyme cascade reactor (3DNECR) through the covalent self-assembly of SpyTag-ADH and SpyCatcher-Dps-ATA117 fusion proteins. The 3DNECR exhibi... |
41793442 | Ultra-trace Determination of Chromium (III) and Cobalt (II) Using Phosphonate Ester-Functionalized PAMAM Magnetite and DSPE-FAAS. | This study reports a simple and efficient dispersive solid-phase extraction (DSPE) method using phosphonate ester-functionalized poly(amidoamine) (PAMAM) dendrimer-coated magnetic nanoparticles for the trace determination of Co(II) and Cr(III) in environmental samples by flame atomic absorption spectrometry (FAAS). The... |
41792243 | BRD9 recognizes lactate-induced H3K18 lactylation to drive oncogenic chromatin remodeling in hepatocellular carcinoma. | Histone lactylation couples glycolytic metabolism to oncogenic transcription, but its mechanistic readers remain poorly defined. Here, we identify bromodomain-containing protein 9 (BRD9) as a lactyl-lysine reader that links lactate-driven H3K18 lactylation (H3K18la) to chromatin remodeling in hepatocellular carcinoma (... |
41792159 | Multi-electron nitrobenzothiadiazole sp-conjugated-alkynyl covalent organic frameworks for ammonium-ion batteries. | Covalent organic frameworks containing periodic redox-active motifs and conjugation structures are booming as competitive negative electrodes for ammonium-ion batteries. Introducing substantial single-electron active motifs linked by dynamic imine bonds can increase their capacity; however, this design is constrained b... |
41971687 | Gradient Copolymers: A Complex Comonomer Incorporation Reality behind the Perfect Ideal. | Gradient copolymers, which feature a gradual transition in monomer composition along the polymer backbone, uniquely combine tunable material properties with inherent stochasticity at the molecular level, bridging the structure-property landscape between block and random copolymers. Their broad glass transition temperat... |
41971688 | Introduction of Self-Healing and Recyclable Properties into Functionalized Polyisoprene Rubber via Thiol-Ene Reaction. | Covalently cross-linked rubbers face persistent sustainability challenges due to their irreversible networks hindering recycling, while polarity mismatch complicates the incorporation of additional self-healing materials into vulcanization-free cis-1,4-polyisoprene (PI). To advance the sustainable development of functi... |
41952984 | Removal of Pb(II) ions from lead-ammonia complex wastewater by the magnetite particles prepared at ambient temperature. | Magnetite (Fe<sub>3</sub>O<sub>4</sub>) were successfully synthesized at ambient temperature (25°C) as the adsorbent for the removal of Pb(II) ions from lead-ammonia wastewater. The magnetite exhibited a magnetization saturation value of 82.30 emu/g, illustrating the magnetite particles could be readily recovered from ... |
41938340 | Computational discovery of SARS-CoV-2 viral entry inhibitory peptides from <i>Androctonus mauretanicus</i> scorpion venom: molecular docking and molecular dynamics simulations targeting the spike protein. | <h4>Background and objective</h4>While vaccination remains central to controlling the COVID-19 pandemic, the emergence of SARS-CoV-2 variants with partial resistance to immune responses has highlighted the need for complementary therapeutic strategies. Among these, antiviral agents that inhibit viral entry mechanisms a... |
41908420 | A Triple-Port High-Pressure Volumetric Sorption Analyzer: Calibration, Measurements, and Uncertainty Analysis for Refrigerant Blend Separation Applications. | A triple-port automatic high-pressure volumetric sorption analyzer was set up for sorption measurements over the temperature range of (273.15-368.15) K and pressures up to 10 MPa. The main function of this apparatus is to rapidly screen porous materials for the separation of a specific gas mixture by measuring adsorpti... |
41908158 | The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice. | At present, there are no FDA-approved orally-available bone anabolic agents to treat osteoporosis. PTH stimulates bone formation through an intracellular signaling cascade that involves the inhibition of salt-inducible kinase (SIK) isoforms 2 and 3. Therefore, direct small molecule SIK2/SIK3 inhibitors may represent a ... |
41901741 | Glnk Mediates Carbapenem Resistance Through the NtrB/NtrC-OprD Regulatory Pathway in <i>Pseudomonas aeruginosa</i>. | <i>Pseudomonas aeruginosa</i> is a major causative agent of nosocomial infections worldwide. Carbapenems are the first-line agents for combating severe <i>P. aeruginosa</i> infections. However, the increasing prevalence of carbapenem-resistant <i>P. aeruginosa</i> (CRPA) has developed as a critical threat to global hea... |
41900816 | From Pathology to Formulation: Designing Biodegradable Polymers for Personalized Drug Delivery. | <b>Background/Objectives:</b> Selection of polymer carriers for targeted drug delivery is typically guided by material availability or trigger responsiveness rather than disease-specific evidence. However, successful preclinical formulations may already encode implicit design rules linking polymer composition to partic... |
41900817 | Design and In Vitro Evaluation of Cyclodextrin-Functionalized Albumin Nanoparticles for Intranasal Carbamazepine Brain Delivery. | <b>Background/Objectives</b>: Poor aqueous solubility and limited nasal permeability remain key challenges in the intranasal delivery of carbamazepine. In this study, biocompatible bovine serum albumin nanoparticles functionalized with sulfobutyl-β-cyclodextrin (SβCD-BSA NPs), comprising individually cytocompatible com... |
41900358 | The Silent Pandemic: Antifungal Resistance and the Future of Invasive Fungal Disease Management. | Invasive fungal diseases (IFDs) represent an escalating global health threat, compounded by the rapid emergence of antifungal resistance (AFR). This review synthesizes the contemporary landscape of AFR from clinical and microbiological perspectives, providing actionable insights for clinical practitioners. We examine t... |
41900351 | Artificial Intelligence-Driven Discovery and Optimization of Antimicrobial Peptides Targeting ESKAPE Pathogens and Multidrug-Resistant Fungi. | Antimicrobial resistance (AMR) poses an escalating global health crisis driven by multidrug-resistant ESKAPE pathogens and emerging fungal threats such as <i>Candida auris</i> (<i>C. auris</i>). In response to this urgent need for new therapeutic strategies, antimicrobial peptides (AMPs) represent a mechanistically dis... |
41900215 | A Smartphone-Driven Acoustic Platform for Non-Invasive Modulation of Cellular Behavior in Microfluidic Channels. | In recent years, passive cell manipulation in microfluidic devices has emerged as a crucial tool for biomedical and biotechnological applications, allowing control over cell positioning and behavior without the need for chemical labels or complex external forces. However, achieving precise and tunable modulation of cel... |
41897332 | Synthetic Modulators of the Vitamin D Receptor: From Structural Innovation to Disease-Specific Applications. | Vitamin D signaling via the vitamin D receptor (VDR) regulates calcium-phosphate homeostasis and extensive gene programs controlling cell proliferation, differentiation, immune tone, and metabolism. However, systemic use of the natural agonist 1α,25-dihydroxyvitamin D<sub>3</sub> (calcitriol) for extraskeletal indicati... |
41893779 | Investigation on a Freeze-Drying Process for Long-Term Stability of mRNA-LNPs. | <b>Background</b>: Thermostability remains a key bottleneck for equitable access to mRNA-LNPs vaccines, mainly due to cold-chain requirements. <b>Objectives and methods</b>: Here, we optimized freeze-drying formulations by screening excipients (sugars, sugar alcohols, and proteins) and buffers to preserve mRNA-LNPs as ... |
41892961 | Marine Lectins in Innate Immune Modulation: Mechanistic Insights, Signaling Pathways, and a Cross-Taxa Evidence Landscape. | Marine lectins function as pattern recognition receptors in innate immunity through carbohydrate-binding mechanisms. However, mechanistic evidence detailing intracellular signaling cascades (e.g., MAPK/NF-κB/JAK-STAT activation linked to defined cytokine outputs) remains taxonomically uneven. Bivalve mollusks-particula... |
41892541 | Solvent Removal Salicylic Acid-Loaded Myristic Acid-Based In Situ Forming Gel. | This study aimed to develop a solvent removal-based in situ forming gel (ISG) loaded with salicylic acid (SAL) using myristic acid (MYR) as a matrix-forming agent. SAL-loaded MYR-based ISGs were prepared using N-methyl-2-pyrrolidone (NMP) or dimethyl sulfoxide (DMSO) as solvents and evaluated for physicochemical proper... |
41892539 | The Influence of Cations and Host-Guest Interactions on Alginate Gels Properties. | Ionotropic alginate-based hydrogelation by divalent metal interaction has been employed to study the effect that different types of ions might have on gel formation. In this regard, EPR and IR spectroscopies, as well as rheology techniques, have been used to evaluate the influence of divalent cations on gel formation, ... |
41890558 | Near infrared light regulated crystallization-driven self-assembly: a versatile platform for controlled preparation of uniform π-conjugated functional nanostructures. | Photo-controlled block copolymer self-assembly to modulate the morphology and dimensions of polymer nanoparticles (PNPs) has attracted growing interest. However, most photo-induced polymer self-assembly approaches are dependent on ultraviolet- or visible-light-based photochemical reactions that lead to structural varia... |
41869362 | Machine learning reveals targets of <i>Gnaphalium hypoleucum</i> DC. flavonoids against rheumatoid arthritis through gut microbiota and anti-inflammation. | <h4>Background</h4>Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and gut microbiota dysbiosis. <i>Gnaphalium hypoleucum</i> DC. total flavonoids (GHTFs) exhibit anti-inflammatory and immunomodulatory properties.<h4>Methods and results</h4>In this study, we employed an integrat... |
41868357 | <i>Mycobacterium tuberculosis</i> MarR family transcription factor Rv0737 regulates bacterial growth and lipid synthesis by targeting the sigL-rslA operon. | The MarR family of transcription factors in <i>Mycobacterium tuberculosis</i> plays a critical role in bacterial adaptation to host stresses, yet the function of many members remains unknown. Here, we characterize the novel MarR regulator Rv0737 and its homolog Ms_1492 in <i>M. smegmatis</i>. Overexpression of Rv0737 s... |
41867950 | Vesicles: a supramolecular tool to achieve organic reactions in aqueous media. | Vesicles are fascinating supramolecular aggregates that can provide an interface-rich microenvironment and confined space. They can incorporate hydrophilic materials in their aqueous core and hydrophobic materials in their bilayer membrane. Thus, they can be utilized to perform organic reactions in water. Using water a... |
41867607 | Umbelliferone Inhibits Zika Virus (ZIKV) NS5 Activity and Replication <i>In Vitro</i>. | This study focused on the inhibitory effects of umbelliferone on Zika virus (ZIKV) NS5 activity and viral replication <i>in vitro</i>. Umbelliferone exhibited no detectable cytotoxicity and inhibited ZIKV replication while showing no activity against Japanese encephalitis virus (JEV), another member of the Flaviviridae... |
41867582 | Factorial Design-Driven Optimization of Zein-Chitosan Nanoparticles for Oral Delivery of Silibinin. | Silibinin (SLB) is a poorly water-soluble flavonolignan with relevant therapeutic potential but limited oral bioavailability. In this study, SLB-loaded zein-chitosan nanoparticles (SLB-ZNP) were developed by nanoprecipitation and optimized using a full 2<sup>4</sup> factorial design to investigate the effects of zein c... |
41853701 | Small extracellular vesicle-integrated by herbal hydrogels for spatiotemporal immunomodulation and neurovascular repair following traumatic brain injury. | Traumatic brain injury (TBI) causes acute neuronal and vascular damage accompanied by intense neuroinflammation, yet current surgical and pharmacological interventions yield limited long-term benefits. Embryonic stem cell-derived small extracellular vesicles (ESC-sEV) carry potent pro-repair signals but suffer from poo... |
41853598 | From chemical characterization to functional validation: Screening of anti-hyperglycemic components and their action mechanisms in differentially fermented teas. | Single-source <i>Jinxuan (Camellia sinensis)</i> tea leaves were processed into teas with varying fermentation degrees to minimize genetic and environmental interference. Non-volatile component differences between fermented and non-fermented teas were identified, with fermented teas showing reduced tea polyphenols and ... |
41853576 | Efficient persistent afterglow modulation using extended Indolo[2,3-<i>a</i>]carbazoles with six-membered rings in a polymer matrix. | Organic persistent afterglow materials exhibit tremendous promise for applications in optoelectronic displays, anti-counterfeiting, and information encryption. Here, we introduce a structural modulation strategy in which a flexible cyclohexyl or rigid phenyl substituent is added to a 11,12-dihydroindolo[2,3-<i>a</i>]ca... |
41853232 | <i>In silico</i> based exploration of natural and synthetic antidiabetic compounds: A comprehensive review of computational approaches. | <h4>Background and purpose</h4>Diabetes mellitus type 2 is a global health issue marked by hyperglycemia and metabolic dysfunction. Despite progress, discovering safe and effective antidiabetic agents remains crucial. This review highlights integrated In Silico, In Vitro, and <i>in vivo</i> methods for identifying nove... |
41850011 | Deconvoluting electrostatic, noncovalent, and magnetic effects of iron-sulfur cofactors inside synthetic cage frameworks. | The electronic states of iron‑sulfur (Fe-S) clusters in metalloenzymes are critically influenced by second and outer-sphere interactions-electrostatics, hydrogen bonding, and hydrophobic contacts-that modulate cofactor redox potentials and reactivity in processes ranging from cellular respiration to nitrogen fixation. ... |
41836540 | Achiral benzoic acid appended helical polymers for the copper-catalyzed asymmetric Diels-Alder reaction and Michael addition with excellent enantioselectivity and recyclability. | One-handed helical polyisocyanides bearing achiral benzoic acid pendants were readily synthesized <i>via</i> the asymmetric polymerization of achiral isocyanides using chiral Pd(ii) catalysts. Despite the inexistence of any stereogenic centers, these polymers showed significant optical activity owing to their one-hande... |
41833184 | Metal-organic frameworks for the fabrication of hemoglobin-based oxygen carriers: A comprehensive review. | Transfusions of red blood cells (RBCs) are a cornerstone of modern medicine but face major challenges, including limited supply, short shelf life, and risk of infection. Hemoglobin-based oxygen carriers (HBOCs) have long been investigated as blood substitutes, yet instability, oxidative toxicity, and rapid clearance of... |
41830721 | A novel and thermostable cyclomaltodextrin glucanotransferase from Anoxybacillus rupiensis PSO2 isolated from Yumthang hot spring: cloning and functional characterisation. | Cyclomaltodextrin glucanotransferase (CGTase) converts starch into cyclic oligosaccharides (cyclodextrins) with broad industrial relevance in starch-saccharification and bioconversion processes. Here, we report cloning, expression, biochemical characterisation and in silico structural analysis of a novel, thermostable ... |
41829202 | Inter-Row Reflective Film Mulching Revealed the Regulation of Ground-Reflected Light on Grape Flavoromics. | Inter-row mulching with reflective film (RF) has been increasingly adopted in cool-climate vineyards to improve light availability and promote grape ripening. This study investigated the effects of ground-reflected light on the flavoromic profiles of wine grape berries (<i>Vitis vinifera</i> L.) over two consecutive vi... |
41828861 | Copper Complexes: Main Mechanisms as Anticancer Agents. | Copper is an essential element for living organisms, being a cofactor for numerous enzymes or proteins involved in oxidation-reduction reactions, intervening in numerous metabolic processes. In recent decades, complex copper combinations have consolidated their position in medicinal chemistry, which is manifested by th... |
41828276 | A Review and Experimental Study on the Performance of Rubberised Concrete Under Combined Freeze-Thaw and Sulphate Attack. | The use of end-of-life tyre (ELT) rubber as a partial aggregate replacement in concrete represents a promising route for waste valorisation; however, its durability-related behaviour and long-term performance remain insufficiently characterised, particularly under combined environmental exposures. This study addresses ... |
41821641 | A Five-Gene PANoptosis Signature Correlates with Immune Infiltration and Secondary Brain Injury in Intracerebral Hemorrhage. | <h4>Objective</h4>Primary intracerebral hemorrhage (ICH) is a severe stroke subtype characterized by high mortality and disability rates, largely attributable to secondary brain injury (SBI). While programmed cell death (PCD) pathways contribute to SBI, their mechanisms remain incompletely understood. This research inv... |
41822908 | Sugammadex vs Neostigmine for Reversal of Neuromuscular Blockade and Association with Postoperative Atelectasis After Video-Assisted Thoracoscopic Surgery: A Propensity Score-Matched Cohort Study. | <h4>Purpose</h4>Postoperative atelectasis remains a significant concern after video-assisted thoracoscopic surgery (VATS). This study aimed to evaluate the association between sugammadex use and postoperative atelectasis in patients who underwent VATS.<h4>Patients and methods</h4>From the TriNetX Global Collaborative N... |
41822853 | Carbohydrate-Based Hydrogels: Weaving Nature's Versatility into Biomedical Innovation. | During the past few years, the development of innovative hydrogels for biomedical applications has undergone significant advancements. Among the diverse classes of soft biomaterials, carbohydrate-based hydrogels have attracted particular attention due to their intrinsic biocompatibility, biodegradability, and high vers... |
41819660 | Electrical stimulation-induced π-π stacking drives sludge humification to enhance direct interspecies electron transfer and methanogenesis. | Electrical stimulation has been applied to enhance anaerobic digestion (AD), but its underlying mechanisms remain unclear. This study reveals that electrical stimulation accelerates sludge humification during AD by driving π-π stacking of humic precursors, thereby enhancing electroactivity and methanogenesis. Specifica... |
41818843 | Metal-organic framework MIL-101(Cr) functionalized β-cyclodextrin-modified magnetic multi-walled carbon nanotubes for efficient extraction of amphenicol antibiotics. | Given the extensive use of amphenicol antibiotics and their potential adverse effects on human health, the development of simple and highly sensitive detection methods is essential to ensure food safety. In this work, a novel and highly efficient magnetic sorbent based on β-cyclodextrin-modified magnetic multi-walled c... |
41816617 | Crystalline covalent organic polymer as an effective zincophilic protective layer to boost the performance of aqueous zinc-ion batteries. | Developing an effective layer to isolate zinc anodes from electrolytes, stop side reactions and help uniform zinc deposition in aqueous zinc-ion batteries (AZIBs) is very important and highly desirable. However, most reported protective layers have less effective ion transport channels and poor zincophilicity, leading ... |
41815208 | Nanobody-Based Drug Delivery: Emerging Strategies for Targeted Cancer Therapy. | Traditional cancer treatments such as chemotherapy and radiotherapy remain effective but lack specificity, often causing collateral damage to healthy tissues. Antibody-drug conjugates (ADCs) using monoclonal antibodies (mAbs) have been developed to achieve advanced targeted delivery; however, preclinical and pharmacoki... |
41812406 | Solvent-triggered dual-emission switching of carbon dots for ratiometric discrimination of methanol and ethanol. | Developing robust methods to discriminate methanol from ethanol is critical for industrial safety and quality control. Herein, we report a novel strategy of two-step solvothermal method to synthesize dual-emission carbon dots (p-PD CDs) from p-phenylenediamine. The p-PD CDs exhibit unique, solvent-dependent fluorescenc... |
41810044 | Naphthalene-Modified Cationic Initiators for Superior Polymerization Stability and Thermal Conductivity in Epoxy Thermosets. | Naphthalene-modified cationic initiators with tunable counteranions were developed to extend the epoxy curing lifetime, enabling the efficient formation of high-ordered networks in both conventional and liquid crystalline (LC) epoxy systems. The extended lifetime of these initiators allows the LC epoxies to maintain th... |
41810042 | Industrial-Scale Seawater Splitting at Engineered Interface of Boron-Doped Cobalt Sulfide/Metal-Organic Framework Nanosheets Heterostructure. | Seawater electrolysis faces several significant obstacles, including low energy efficiency and anode corrosion due to chlorine chemistry, which limit its practical potential. To overcome this, we developed a catalyst composed of boron-doped CoS<sub>2</sub> protected by metal-organic framework sheets (MOFs) (B-CoS<sub>2... |
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