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41807892 | Effect of ultrasonic-assisted hot-air drying on the quality and drying kinetics of Taraxacum mongolicum. | Drying of Taraxacum mongolicum Hand.-Mazz (TMHM) was an effective approach for preventing spoilage and extending shelf life. Ten drying methods were systematically evaluated, among which ultrasonic-assisted hot-air drying (Us-HA-D) was identified as the most suitable technique. The drying kinetics analysis indicated th... |
41806727 | A hierarchical three-dimensional SERS substrate for trace pesticide residue detection. | Pesticide residues detection is critical for protecting health and food quality. Surface-enhanced Raman scattering (SERS) has become a highly effective technique for pesticide analysis, with substrate performance largely dependent on material structure and surface properties. This study developed a three-dimensional hi... |
41799921 | Hinokitiol-fueled disks form exclusionary zones in the presence of iron. | Stimuli-responsive, directional motions, such as chemotaxis, are vital for the development of sophisticated synthetic systems with autonomous motility. Here, we demonstrate that disks containing hinokitiol exhibit directional self-propelled motion on water in response to metal ions, particularly Fe(iii) ion. The self-p... |
41799901 | Recent advances in enhancing the luminescence efficiency of rare earth upconversion nanoparticles for biomedical applications. | Rare earth upconversion nanoparticles (UCNPs) have made remarkable progress in overcoming the limitations of traditional optical probes in biomedical applications, such as shallow tissue penetration and strong background interference, owing to the anti-Stokes luminescence properties of near-infrared excitation followed... |
41798690 | Ciliary Defects in Inherited Retinal Diseases. | Inherited retinal diseases (IRDs) are a heterogeneous group of disorders characterized by progressive photoreceptor degeneration that frequently results in severe vision loss. A major cause of IRDs is attributed to structural or functional defects of the photoreceptor cilium that arise from mutations in ciliary genes. ... |
41798633 | Microenvironment regulation in nanomaterial synthesis. | The controllable synthesis of nanomaterials serves as the core driving force for the development of energy, catalysis, biomedicine and other fields. Their performance depends on microstructures including size and morphology, whose formation is precisely regulated by the synthetic microenvironment. Traditional macroscal... |
41796875 | Metal-organic frameworks for topical and transdermal therapeutics. | Topical and transdermal therapeutics are critical for managing dermatological and mucosal disorders. Conventional formulations, including creams, ointments and gels, face limitations such as inefficient drug penetration, uncontrolled release kinetics, and inability to respond to dynamic pathological microenvironments. ... |
41796798 | Collagen IV of basement membrane: V. Bromide-mediated sulfilimine bonds interlock the quaternary structure of NC1-hexamer of scaffolds enabling metazoan evolution. | Collagen-IV scaffolds, a primordial basement membrane component, enabled animal multicellularity, evolution and adaptation. These scaffolds provide tensile strength and tether macromolecules, forming supramolecular complexes that interact with cell-surface receptors and influence cell-behavior. Triple-helical Col-IV pr... |
41796802 | Evidence that non-cognate proteinogenic amino acids generate immunogenic neoepitopes. | Most organisms rely on 20 DNA-encoded canonical amino acids (AAs) for protein synthesis. However, hundreds of non-canonical amino acids (NCAAs) occur in nature, many of which are plant secondary metabolites. Some NCAAs have been identified as proteinogenic and can mimic canonical AAs in mammalian protein synthesis. The... |
41796803 | Decoding the glycan shield: Immune recognition and response to the HIV-1 envelope trimer. | The HIV-1 envelope glycoprotein (Env) is essential for viral entry and infection of host cells. Composed of a trimer of the gp120-gp41 heterodimeric glycoproteins, the Env trimer is the primary target for neutralizing antibodies. Extensive research over the past 40 years has focused on developing advanced immunogens, s... |
41796801 | The ASC-c isoform as a modulator of inflammasome activation: Insights into molecular mechanisms and therapeutic applications. | Canonical inflammasome assembly is driven by interactions between sensors and effector procaspase-1, primarily mediated by the adaptor ASC. Homotypic interactions between Death Domains pyrin (PYD) and caspase recruitment and activation domain (CARD) lead to sensor and ASC oligomerization, along with the recruitment of ... |
41796682 | The compound LY295427 antagonizes 25-hydroxycholesterol through binding to INSIG. | 25-Hydroxycholesterol (25-HC) regulates cholesterol metabolism by inhibiting the maturation of SREBP and promoting the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). The compound LY295427 can reverse 25-HC-mediated suppression of SREBP processing, but the mechanism is unclear. In addition, it is unkno... |
41794648 | Reprogramming the flavo-encapsulin from Thermotoga maritima to a novel protein nanocage platform for potent photodynamic therapy. | Encapsulins are protein nanocages consisting of a single monomer protein and have gained increasing interest as a platform for diverse biological nanotools due to their ease of production and robust stability. We found that the Thermotoga maritima encapsulin (TmEnc) recombinantly expressed in Escherichia coli possessed... |
41794301 | Controlled polymerization of dextran from sucrose via SpyTag/SpyCatcher-assembled enzyme cascades. | Inspired by natural metabolons, spatial organization of enzymes into complexes is a promising route to enhance cascade catalysis, yet precise control over assembly, efficiency, and product specificity remains challenging. This study presents a systematic comparison between intracellular gene fusion and modular SpyTag/S... |
41794288 | 3D Proteomics: Structural, Functional, Chemical and Biomarker Discovery Proteomics With LiP-MS. | Protein structural dynamics drive changes in protein function, making the capture of such dynamics essential for interrogating biological systems. Here we review limited proteolysis coupled to mass spectrometry (LiP-MS), a structural and chemical proteomics method that uses changes in susceptibility to protease cleavag... |
41794027 | Dynamics of natural selection preceding human viral epidemics and pandemics. | Using a phylogenetic framework to characterize natural selection, we investigate the hypothesis that zoonotic viruses require adaptation prior to zoonosis to sustain human-to-human transmission. Examining the zoonotic emergence of Ebola virus, Marburg virus, mpox virus, influenza A virus, and SARS-CoV-2, we find no evi... |
41793100 | Photochromic Cholesteric Liquid Crystals via Arylazopyrazole Functionalization of Hydroxypropyl Cellulose. | Photochromic materials are of interest for low-power colorimetric sensors, reusable displays, and dynamic optical components. Incorporating photoswitches into cholesteric liquid crystalline mesophases can enable photo-induced shifts in structural color. While cellulose ethers, such as hydroxypropyl cellulose (HPC), con... |
41793024 | Steering the Shape-shifting of Bullvalene-Pd<sup>II</sup> Complexes Through Steric and Geometric Strain. | Di-substituted bullvalenes are fluxional molecules possessing up to fifteen possible isomers. Their shape-shifting nature has been harnessed in host-guest chemistry, drug design, polymers, and electromechanical systems. Despite this, principles for controlling the fluxional pathways of bullvalene, including access to i... |
41792842 | RALP1 is essential for schizont maturation and erythrocyte invasion in Plasmodium falciparum. | <h4>Background</h4>Plasmodium falciparum merozoite invasion of erythrocytes is an essential step in the asexual blood-stage cycle and a major target for antimalarial intervention. Rhoptry neck proteins play key roles in the formation and function of the tight junction, yet many remain poorly characterized. RALP1, a con... |
41792583 | Cannabinoid Oral Mucosal Delivery: Approaches to Formulation, Fabrication, and Permeation Enhancement. | Cannabinoids such as cannabidiol (CBD) and tetrahydrocannabinol (THC) have garnered significant interest for their broad-spectrum pharmacological activity in managing chronic pain, neurological disorders, and cancer-associated symptoms. Despite their therapeutic promise, clinical translation remains hindered by poor aq... |
41792263 | Thymbra spicata extracts against soilborne fungi: linking chemical composition, antifungal activity, and molecular docking insights. | In this study, the antifungal activities of essential oil, supercritical carbon dioxide (SC-CO₂) extract, methanol extract, and SC-CO₂+ethanol extract obtained from Thymbra spicata L. were evaluated in vitro against the soilborne fungal pathogens Sclerotinia sclerotiorum, Macrophomina sp., Rhizoctonia solani, and Fusar... |
41792170 | Tudor domain-containing protein 9-targeting siRNA nanoparticles alleviate Pseudomonas aeruginosa lung injury in preclinical models by promoting neutrophil cuproptosis. | Pseudomonas aeruginosa pneumonia poses a significant therapeutic challenge. Nanoparticles serve as an effective tool for nucleic acid delivery to efficiently alleviate pneumonia. This study develops a hyaluronic acid (HA)-coated peptide nanoparticle system for targeted delivery of small interfering RNA (siRNA) against ... |
41792158 | Chromosome-level genome assembly and annotation of the Rhinogobio ventralis, an endangered endemic fish from the Yangtze River. | Rhinogobio ventralis, a critically endangered freshwater fish endemic to the upper Yangtze River, holds significant ecological and economic value. Here, we present a high-quality chromosome-level genome assembly of R. ventralis. Using a combination of PacBio HiFi long-read sequencing (>99% single-read accuracy), DNBSEQ... |
41792141 | Optimizing spatial organization of FtsZ rings for large-scale constriction in synthetic cells. | Spatially regulated membrane constriction is an important milestone in reconstituting minimal cell division. In giant lipid vesicles, bottom-up approaches have reproduced the assembly, mid-cell positioning, and the initial constriction of an FtsZ-based minimal divisome. However, progressive deformation towards giant ve... |
41792088 | Effect and safety evaluation of MIL-101 loaded with prochloraz against rice sheath blight. | <h4>Background</h4>Rice sheath blight (ShB), a fungal disease caused by Rhizoctonia solani, seriously threatens rice yield and quality. Prochloraz (PRO), a broad-spectrum imidazole fungicide, may cause some harm to the environment and organisms when overused. To improve its efficiency and reduce environmental impact, M... |
41791790 | Integrating interferon gamma receptor pathways, antigenicity, and immune contexture as predictors of immunotherapeutic strategies for mucosal melanomas. | <h4>Background</h4>Mucosal melanomas (MM) arise from mucosal melanocytes at various anatomical sites. These tumors are rare, highly aggressive, and often associated with poor outcomes. Current treatments, including immune checkpoint inhibitors, show limited efficacy in advanced disease. Compared with cutaneous melanoma... |
41791123 | Adsorption of Surfactants and Polymers to Biomimetic Hair Model Surfaces. | Improving the sustainability of cosmetic products while maintaining a good performance requires a deeper understanding on the way that new eco-respectful ingredients interact with hair or skin. In the case of shampoos, the surface science is dominated by the diverse changes on the hair fiber due to both chemical and ph... |
41791001 | Local Pair Natural Orbital-Based Coupled-Cluster Theory through Full Quadruples (DLPNO-CCSDTQ). | In this work, we implement a local pair natural orbital-based coupled-cluster method through the full treatment of quadruple excitations (CCSDTQ). The domain-based local pair natural orbital (DLPNO) approach, which has successfully been applied to lower levels of coupled-cluster theory, is utilized in our algorithm, an... |
41790990 | Multiscale Chirality in Gold Nanoflowers: Chiral Hotspots, Surface Asymmetry, and Molecular Recognition for Enantioselective SERS. | Chiral plasmonic nanostructures have emerged as powerful probes of chirality, yet most rely solely on passive optical asymmetry and rarely exploit analyte manipulation strategies. This limitation constrains their sensitivity and generality across diverse molecular systems. Integrating chirality across multiple length s... |
41790973 | Trustworthy Compound-Protein Interaction Prediction with Interpretable and Conformalized Cross-Attention Transformers. | Deep learning has accelerated drug discovery by enabling large-scale virtual screening, but current models often act as "black boxes" and provide no formal guarantees about prediction reliability. This limitation is particularly critical for compound-protein interaction (CPI) prediction, where data sets are highly imba... |
41790945 | D-amino acid aminotransferase1 regulates grain chalkiness in rice by modulating endoplasmic reticulum stress response. | D-amino acids are key components of the bacterial cell wall and play important roles in neural communication and inflammatory responses in animals. However, knowledge about D-amino acid metabolism and physiological functions in plants is limited. Here, we isolated and characterized a rice <i>D-amino acid</i> <i>aminotr... |
41790944 | Unveiling hidden intermediate states in protein folding with AI-based conditional transition clustering. | Revealing the complex mechanisms of protein folding, including the transient intermediate states that govern the process, is a fundamental goal in computational biophysics. While molecular dynamics (MD) simulations generate vast amounts of data to this end, extracting a clear kinetic model from these complex, high-dime... |
41790925 | Multiple molecular mimics in Epstein Barr Nuclear Antigen-1, and the pathogenesis of multiple sclerosis. | The Epstein-Barr virus (EBV) infects greater than 95% of humans and is associated with initiating and perpetuating multiple sclerosis (MS). Antibody to Epstein-Barr Nuclear Antigen-1 (EBNA1) is present in nearly 100% of patients with MS before the development of clinical symptoms. Infection with EBV is necessary, but n... |
41790885 | Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome. | Toll-like receptors (TLRs) drive innate immunity via assembly of macromolecular signal transduction platforms [supramolecular organizing centers (SMOCs)] coordinated by adaptor proteins such as Toll/interleukin-1 receptor (IL-1R) domain-containing adaptor-inducing interferon-β (TRIF), but whether oligomeric TRIFosomes ... |
41790878 | Two-dimensional NIR-II AIE nanotheranostic probes with ultralarge Stokes shifts for surgical navigation and ablation of glioma. | Near-infrared (NIR) fluorescence probes featuring ultralarge Stokes shifts and efficient aggregate-state luminescence are highly desirable for bioimaging yet remain scarce due to formidable synthetic challenges and intricate photophysical modulation. We report a facile one-step click reaction to synthesize a tetracyano... |
41790600 | Direct Measurement of Protein Pair Interaction Potential. | A direct and unambiguous method for obtaining the pair interaction potential (PIP) of proteins does not currently exist. All existing approaches require solving an inverse problem, which always allows for alternative solutions. Here, we report a straightforward method for obtaining the PIP directly from experimentally ... |
41790568 | Molecular Engineering of Co-doped Mesoporous Polymer-Derived Carbon toward Precise N,O Configurations for Boosting Pd-Catalyzed Selective Alkynol Hydrogenation. | Carbon-supported Pd catalysts are pivotal in alkynol hydrogenation for fine chemicals and pharmaceuticals. Heteroatom doping and porous structures of supports can modulate the metal electronic structure and improve mass transfer, respectively, thereby influencing catalytic activity. However, precise control over doping... |
41790483 | Ligand-Substitution Engineering Enhances Fluorescence Sensing of Antibiotics in Cadmium-Organic Frameworks. | The environmental accumulation of nitrofuran antibiotics, exemplified by nitrofurazone (NZF), poses significant risks to ecosystems and public health, necessitating sensitive and rapid detection methods. Herein, we report a cadmium-based metal-organic framework (Cd-MOF) featuring a 2D → 3D interpenetrated structure and... |
41790374 | Two-dimensional material-polymer hybrid membranes for enhanced mechanical stability and environmental remediation. | Two-dimensional materials (2DMs) have attracted substantial attention due to their exceptional thermal, tensile, chemical, and mechanical properties, making them promising candidates for designing next-generation polymeric membranes. Incorporating 2DMs with polymers not only improved selectivity and permeability but al... |
41790351 | Interpretable machine learning assisted optimization of antimony adsorption by metal-organic frameworks: combined with characterization methods for adsorption mechanism analysis. | Antimony (Sb) contamination in aquatic environments poses serious risks to human health and ecosystem integrity. Conventional remediation techniques for Sb pollution, however, are constrained by inherent limitations, including prolonged treatment durations, intricate optimization of experimental parameters (e.g., pH, t... |
41790244 | Unveiling Guest Structure and Hydrogen Bonding in Cyclohexanemethanol Clathrate Hydrates. | Clathrate hydrates are crystalline inclusion compounds traditionally described as host-guest systems stabilized predominantly by van der Waals interactions. Recent studies, however, have shown that polar guest molecules can engage in weak and transient hydrogen bonding with the hydrate water framework, challenging this... |
41790196 | Temperature-Cycling-Guided Self-Assembly of DNA-Functionalized Nanoparticles for Avoiding Kinetic Traps. | The self-assembly of DNA-functionalized gold nanoparticles is often hindered by kinetic traps arising from excessively strong interparticle interactions, leading to structural defects. To address this, we propose a novel temperature-cycling strategy that reversibly modulates hydrogen bonding between DNA strands (<i>T</... |
41790012 | Unlocking Ultralong Cycle Life and Temperature-Tolerable Secondary Batteries Using a Vacancy-Abundant Co<sub>9</sub>S<sub>8</sub>@ZnS/Carbon Anode. | Sodium-ion batteries face some critical anode-level barriers: sluggish Na<sup>+</sup> transport, conversion-induced instability, and poor temperature adaptability. Here, we develop a vacancy-based synergy in Co<sub>9</sub>S<sub>8</sub>@ZnS/C synthesized by metal-organic framework-templated sulfidation. The Co-Zn-S syst... |
41789924 | Engineering Molecular Assembly for High Performance Plastic Thermoelectrics. | ConspectusThe escalating global energy crisis, coupled with the environmental impact of conventional energy consumption, has intensified the pursuit of green and sustainable energy solutions. Converting low-grade heat into electricity using flexible, lightweight, and solution-processable polymeric thermoelectrics offer... |
41789918 | The EP424R protein of African swine fever virus functions as a 2'-O-methyltransferase and plays an important role in viral replication. | African swine fever (ASF) is a highly pathogenic infectious disease that poses a serious threat to the pig farming industry worldwide. Currently, there are no effective vaccines and drugs. The 5' cap structure of messenger RNAs (mRNAs) is a critical modification that is found in all eukaryotic organisms and many viruse... |
41789838 | Light-Activated Qubit Coupling in a Vanadyl Porphyrin Trimer. | Molecules provide a modular and chemically tunable platform for quantum information science. In recent years, significant advances have been made in enabling optical spin initialization, coherent control, and both optical and electrical readout of molecular qubits. Yet, a central challenge remains: realizing scalable a... |
41789839 | Selective Synthesis of Fluorine Liquid Crystals with a Triphenyleno[2,3-<i>b</i>]benzofuran Core: Heterocyclic Annulation, Columnar Mesophase, and Fluorescence. | Fluorinated discotic liquid crystals are highly promising organic semiconductor materials for electronic device research. Their exceptional self-assembly properties and thermal stability enable the formation of long-range, ordered columnar structures, which are critical for efficient charge transport, ultimately enhanc... |
41789828 | Fast and Efficient Adiabatic Photoisomerization of Linearly Coupled Dithienylethenes. | Understanding and controlling the excited-state pathway dynamics of molecular photoswitches is critical for achieving rapid, efficient, and fatigue-resistant photoisomerization. Conventional diarylethenes (DAEs) undergo close-ring isomerization via nonadiabatic transitions involving conical intersections or intersystem... |
41789627 | FOXM1 inhibitor, RCM‑1, enhances venetoclax mediated apoptosis through downregulation of ATP2B4 in rhabdomyosarcoma. | Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children. Intensifying chemotherapy has failed to improve patient survival for metastatic or relapsed RMS and RMS survivors often suffer from significant long‑term toxicities. More efficient and less toxic new therapies are critically needed. RMS ... |
41789574 | Prostate‑specific membrane antigen: Molecular functions and emerging roles as a therapeutic target (Review). | The present review focuses on the molecular functions of prostate‑specific membrane antigen (PSMA) as a biologically active protein. Its clinical use as a positron emission tomography imaging marker or radioligand therapy target is beyond the scope of the current review. The role of PSMA (also known as folate hydrolase... |
41789526 | Positively Charged Polymer-Brush MOFs for Large-Area, Pressure-Resistant Gas Separation Membranes. | Scalable fabrication of high-performance gas separation membranes remains a major challenge for energy-efficient gas purification. Industrial translation of pressure-resistant mixed matrix membranes (MMMs) is largely impeded by the dispersion instability of nanofillers under rapid, non-equilibrium manufacturing conditi... |
41789527 | Ligand-Mediated Interfacial Hydrogen Bonding Networks in Metal Organic Frameworks for High-Performance 5-Hydroxymethylfurfural Electrooxidation. | Inspired by the 3D microenvironment modulated precise and efficient catalytic reactions in nature enzyme systems, we designed a NiCo-based catalyst with 3D modulated microenvironments for high-performance 5-hydroxymethylfurfural (HMF) oxidation reaction by constructing metal organic frameworks (MOFs) with different sid... |
41789456 | A Stepwise-Enhanced Schottky Heterojunction Enables Ultra-Low-Dose Radiodynamic Therapy via Matrix Remodeling and Electron-Hole Separation. | Radiodynamic therapy (RDT) enhances the production of reactive oxygen species (ROS), thereby reducing clinical radiotherapy doses. Nanoscale metal-organic frameworks (nMOFs) based on high-Z secondary building units (SBUs) and photosensitizing ligands have been developed to perform RDT. However, the rapid recombination ... |
41789461 | Repositioning the Leader Peptide in Graspetide Biosynthesis. | Applying enzymes from unique biosynthetic pathways in a combinatorial fashion to garner new-to-nature products has been a long-standing goal of synthetic biology. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a family of natural products that comprise a broad array of chemical and struc... |
41789447 | Assembling a True "Olympic Gel" From over 16 000 Combinatorial DNA Rings. | Olympic gels are an elusive form of soft matter, comprising a 3D network of mechanically interlocked cyclic molecules. In the absence of defined network junctions, the high conformational freedom of the molecules was previously theorized to confer unique mechanical properties to Olympic gels, such as non-linear elastic... |
41789438 | Preparation of Porous MOF-Polymer Composites via High Internal Phase Pickering Emulsions for Dye Adsorption Applications. | A versatile strategy for fabricating hierarchically porous monoliths was established using UiO-66/TOCNC metal-organic framework composites as stabilizers for pickering emulsions. Polymeric materials produced from high internal phase emulsions (polyHIPEs) using this approach offer scalable and mild processing conditions... |
41787955 | Cell Cycle-Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET. | Centrosome amplification in cancer cells produces excess centrosomes that cluster and decluster throughout the cell cycle, a process critical for tumorigenesis. Here, we identify the mitotic kinesin HSET as a multifaceted regulator of these dynamics in cancer cells. Beyond microtubule crosslinking, HSET co-condensates ... |
41787520 | Optimized New Shengmai Powder suppresses ferroptosis in ischemic cardiomyocytes via cGMP-PKG signalling. | <h4>Background</h4>Shengmai Powder is a classic Traditional Chinese Medicine formula that has been used for centuries to manage cardiovascular diseases characterized by "Qi-Yin deficiency with blood stasis." Optimized New Shengmai Powder (ONSMP), a modern refinement of this formula, has shown clinical efficacy in impro... |
41787034 | The extracellular matrix in inflammation and cancer. | The extracellular matrix (ECM) forms a dynamic structure around cells, providing environmental cues, mechanical support, and tissue protection. It is composed of fibrous proteins, glycosaminoglycans (GAGs), proteoglycans, and glycoproteins. The molecular, physical, and mechanical properties of the ECM regulate the moti... |
41786968 | Nanoliposome mediated co-delivery of amoxicillin and tazobactam remediate intracellular infection by a multidrug-resistant Salmonella enterica serovar Typhimurium. | Multidrug-resistant (MDR) Salmonella enterica serovar Typhimurium (S. Typhimurium) poses a growing threat to food safety and animal health, particularly in the swine industry. In this study, we characterized a highly resistant ST strain isolated from a Quebec swine farm using whole-genome sequencing and phenotypic assa... |
41786683 | Lactylation as a metabolic-epigenetic switch in cancer: dual roles in cell death resistance and therapeutic vulnerability. | Protein lactylation emerges as a pivotal metabolic rheostat, translating microenvironmental lactate flux into stable programs that orchestrate cancer treatment resistance. This review synthesizes recent advances under the framework of "Lactylation Switch in Cancer Vulnerabilities." We dissect the dominant enzymatic pat... |
41982713 | BBB-Permeable PROTACs: Where Do We Stand? | The development of CNS-active PROTACs is limited by the blood-brain barrier (BBB). This Microperspective briefly reviews BBB physiology and critically evaluates current <i>in silico</i>, <i>in vitro</i>, and <i>in vivo</i> models used to assess brain penetration. These considerations enable a unified analysis of the 30... |
41953343 | An unusual two-dimensional MOF formed from Ni<sup>II</sup>, thio-phene-2,5-di-carboxyl-ate and <i>trans</i>-1,2-bis-(pyridin-4-yl)ethyl-ene. | A new Ni<sup>II</sup> MOF, poly[[sesqui[μ-<i>trans</i>-1,2-bis-(pyridin-4-yl)ethyl-ene](μ-thio-phene-2,5-di-carboxyl-ato)nickel(II)] di-methyl-formamide 0.205-solvate], {[Ni(C<sub>6</sub>H<sub>3</sub>O<sub>4</sub>S)(C<sub>12</sub>H<sub>10</sub>N<sub>2</sub>)<sub>1.5</sub>].0.205C<sub>3</sub>H<sub>7</sub>NO} <sub><i>n</... |
41938136 | A dual-responsive CO-releasing nanogel ameliorates retinal ischemia-reperfusion injury by restoring mitochondrial homeostasis and attenuating cGAS-STING pathway activation. | Retinal ischemia-reperfusion injury (RIRI) represents a central pathological mechanism underlying neurodegeneration in multiple blinding ocular diseases, including glaucoma, diabetic retinopathy, and retinal vein occlusion. Ischemic stress triggers a surge of reactive oxygen species (ROS) within retinal ganglion cells,... |
41918884 | Mechanisms and therapeutic strategies of copper homeostasis in the pathogenesis of sepsis-induced cardiomyopathy. | Sepsis-induced cardiomyopathy (SCM) is a severe, mortality-increasing sepsis complication, with copper homeostasis imbalance as a key pathogenic factor. Copper (Cu) plays a dual role: as an essential enzyme cofactor, it regulates vital processes including energy metabolism and redox balance; however, both excess and de... |
41909222 | Transdermal needle-free drug delivery approaches and activation mechanism. | The evolution of transdermal drug delivery (TDD) systems has transformed non-invasive drug delivery by improving safety, precision, and patient compliance. While conventional TDD methods face challenges with penetration efficiency and dosage control, needle-free transdermal drug delivery technologies are emerging as a ... |
41908958 | Dietary energy alters jejunal microbial function without changing its structure in small-tailed Han sheep. | Dietary energy levels typically influence the structure and functional profile of the gastrointestinal microbial community. In this study, thirty 6-month-old Small-tailed Han (STH) sheep were randomly divided into three groups and fed corn-based diets with different energy levels for 150 days. Jejunal contents were the... |
41907319 | Silyl Hot-Injection Versus Thiocyanate Heat-Up Synthesis of Chalcohalides: Pushing the Size and Composition Envelope. | Chalcohalide semiconductors are rapidly gaining traction as stable, biocompatible materials for energy conversion applications. While the solid-state synthesis of bulk chalcohalides is relatively well-developed, the colloidal chemistry of these materials is still in its early stages. Colloidal semiconductors are often ... |
41903966 | Flower-like ZIF-L@Au NTs composite integrated with enrichment-enhancement ability for SERS detection of lung cancer VOC biomarker. | <h4>Background</h4>Volatile organic compounds (VOCs) in human exhaled breath serve as molecular fingerprints that reflect metabolic dysregulation and can indicate the onset and progression of diseases such as lung cancer. Surface-enhanced Raman scattering (SERS), characterized by its high sensitivity, molecular specifi... |
41900212 | A Dissolving Microneedle Design for Poorly Water-Soluble Drugs for Enhanced Skin Permeation and Transdermal Delivery Fabricated Using 3D Printing. | Microneedles (MNs) offer a transformative platform for transdermal drug delivery, though balancing structural precision with mechanical robustness remains challenging. This study utilized SLA 3D printing to fabricate high-resolution MN masters, systematically evaluating printing angles (0° to 60°) and aspect ratios to ... |
41899433 | Polymer Nanoparticle-Based Photodynamic Therapy Combined with Immunotherapy for Solid Tumor Treatment. | Polymer nanoparticles have been widely studied for tumor treatment due to their excellent biocompatibility, structural diversity, and multi-functionality. Among their various applications, combining polymer-based photosensitizers with photodynamic therapy (PDT) and immunotherapy has emerged as a promising strategy for ... |
41898227 | Computational Pharmacodynamic Analysis of Cyclopeptides Derived from c[Trp-Phe-D-Pro-Phe] (CJ-15,208), an Unusual Class of Mixed μ/k-Opioid Receptor Ligands Lacking the Traditional Pharmacophores. | <b>Background:</b> There is currently increasing interest in atypical opioid compounds capable of expanding their clinical applications beyond pain management, including the treatment of psychiatric disorders and substance abuse. In this context, the cyclotetrapeptide c[Trp-Phe-D-Pro-Phe] (CJ-15,208, <b>1</b>) and its ... |
41897329 | Glycogen Hydrogel Loaded with <i>Schistosoma japonicas</i> Peptide SJMHE1 Improves Skin Wound Healing. | Current wound healing strategies must confront numerous challenges. Helminth-induced immunomodulation offers a promising therapeutic avenue for inflammatory diseases and injury repair. However, research on the role of helminths in damage recovery remains limited. We utilized glycogen-a naturally occurring biomaterial-t... |
41893777 | Preparation and Immunogenicity Prediction of <i>Brucella melitensis</i> mRNA Vaccine Candidate Based on <i>omp16</i> and <i>omp19</i> Genes. | <h4>Background</h4><i>Brucella</i> outer membrane proteins (Omps) are an important part of its cell wall and major virulence-related factors. Omp16 and Omp19 proteins are the advantageous antigens of <i>Brucella</i> and have been widely used in research on vaccines against brucellosis. As an emerging vaccine, the mRNA ... |
41893776 | A Precision-Engineered DC-Targeting mRNA-LNP Neoantigen Vaccine Elicits Stronger T Cell Responses and Exhibits Superior Tumor Control. | <b>Background/Objectives</b>: Messenger RNA (mRNA) vaccine technology has shown great potential in the prevention of infectious diseases and treatment of cancers, but its full potential is limited by non-specific delivery mediated by the current lipid nanoparticle (LNP) platform. <b>Methods</b>: Here, we developed a de... |
41892537 | Gel Microspheres as Multifunctional Carriers for Photodynamic Therapy: Advancing Hepatocellular Carcinoma Treatment. | Conventional hepatocellular carcinoma (HCC) treatments suffer from insufficient efficacy and severe toxic side effects. This review addresses these issues by focusing on gel microsphere-mediated photodynamic therapy (PDT) as a novel strategy. It outlines the core properties, classifications, and stimulus-responsive mec... |
41892432 | Novel Insights into Carbapenem Resistance: Mechanisms, Diagnostics, and Future Directions. | Carbapenems are essential for the treatment of severe infections caused by Gram-negative bacteria, particularly in critically ill and immunocompromised patients. However, the global rise of carbapenem-resistant Enterobacterales (CRE), <i>Pseudomonas aeruginosa</i>, and <i>Acinetobacter baumannii</i> has significantly e... |
41883582 | A transferable SARS-CoV-2 IRES module enables dual translation initiation for enhanced antigen expression in COVID-19 mRNA vaccines. | mRNA vaccines are a versatile platform for infectious disease prevention and therapeutic applications, yet their performance is limited by exclusive reliance on cap-dependent translation, which is markedly suppressed under hypoxia and cellular stress. Here, we report a hybrid 5' untranslated region (5'UTR) that enables... |
41877985 | Color-tunable hot-exciton organic glassy supramolecular scintillators enabled by host-guest co-melting. | Organic glassy scintillators are promising for radiation detection owing to their low cost and facile processability. However, their performance is often constrained by insufficient X-ray absorption and scintillation quenching during vitrification from a single crystal to glass. Herein, we present a co-melting strategy... |
41869323 | From soluble uric acid to sodium urate crystal: immune metabolic inflammation driven by uric acid morphological transformation and mechanism-oriented therapy. | Uric acid has complex bidirectional effects on human physiology and disease, influenced by its antioxidant capacity, metabolic regulatory roles, and pro-inflammatory properties, all of which are highly context-dependent. In this review, we synthesize recent advancements related to the continuum from soluble uric acid (... |
41868241 | Immunoinformatic insights for design and clinical prospects of pan-RAS cancer vaccine. | <h4>Introduction</h4>KRAS mutations, particularly at codon 12, occur in over 90% of pancreatic ductal adenocarcinoma (PDAC) cases and drive tumor initiation, progression, and therapeutic resistance. Targeting oncogenic KRAS variants through immunotherapy offers a promising strategy for PDAC treatment. This study evalua... |
41868236 | Immunoinformatics-driven multi-epitope vaccine design targeting PSMA, STEAP1, and B7H3 for prostate cancer. | <h4>Introduction</h4>Prostate cancer remains a major global health challenge, necessitating precision immunotherapeutic strategies tailored to tumor-associated antigens. This study aimed to design a multi-epitope peptide vaccine targeting prostate-specific membrane antigen (PSMA), six-transmembrane epithelial antigen o... |
41868141 | Respiratory enterovirus D68: virology, clinical surveillance, host-pathogen interactions, and therapeutic prospects. | Enterovirus D68 (EV-D68), a unique enterovirus resembling human rhinoviruses, was long considered to cause only sporadic outbreaks of mild, self-limiting respiratory infections mainly in children. However, over the past decade, EV-D68 has exhibited a biennial outbreak pattern across multiple regions worldwide, coincidi... |
41868124 | Pyrimidine nucleoside: inspiration for novel antimicrobial agent. | Antimicrobial resistance (AMR) is a worsening global health crisis, with drug repurposing emerging as a key mitigation strategy. Pyrimidine nucleosides are promising antibacterial scaffolds due to their easily modifiable structures and multi-therapeutic potential. However, related research faces challenges, including f... |
41867952 | Emerging insights into chemistry and therapeutic potentials of functionalized hexahydroquinolines. | Quinolines are well-established scaffolds in drug discovery and form the core of many FDA-approved medicines. Among their reduced analogues, hexahydroquinolines (HHQs) have gained increasing attention due to their structural adaptability and broad pharmacological relevance. Research has largely focused on the 1,4,5,6,7... |
41867949 | Artificial intelligence modeling and investigation of metal organic frameworks in drug delivery: modeling of loading capacity and toxicity behavior. | In this work, our aim was to develop predictive models of Drug Loading Capacity (g/g) and Cell Viability (%) in MOFs (Metal Organic Frameworks) for evaluation of these materials in drug delivery applications and assess their performance. We employed Gaussian Process Regression (GPR) and its advanced variants: Sparse Ga... |
41867620 | Exploring Trop-2-Nanobody PPI Interactions through Molecular Dynamics Simulations and Biovalidations. | The transmembrane glycoprotein Trop-2 has garnered significant attention as a potential therapeutic target due to its involvement in various malignancies, including breast, lung, and prostate cancers. Specifically, the exploration of Trop-2-specific antibodies and nanobodies has emerged as a promising avenue for innova... |
41867592 | Red Mud-Based MIL-53(Fe) for the Efficient Adsorption of Methylene Blue: Preparation, Adsorption Performance, and Mechanism. | This work reports the use of red mud (RM) (a widely available industrial byproduct) as the primary raw material for synthesizing cost-effective MIL-53-(Fe) (denoted as RM-MIL-53-(Fe)), which was subsequently applied for the high-efficiency removal of methylene blue (MB) from aqueous environments. The optimum preparatio... |
41867595 | Agglomerations of Methane Hydrate Particles in Aqueous Solutions: Insight from Dissipative Particle Dynamics Simulations. | Despite the common occurrence of hydrate particle agglomerations in engineering applications and naturally occurring environments, there is still a gap in exploring the agglomeration mechanism of gas hydrate particles in aqueous solutions due to the experimental challenges and limitations. Herein, particle agglomeratio... |
41859516 | The fine effects of high magnetic fields on hyperfine shifts. | We report a comprehensive investigation of the magnetic field dependence of NMR hyperfine shifts in paramagnetic systems, a critical observable in the study of molecular magnetism. By combining high-field NMR experiments with quantum chemical calculations, we demonstrate that hyperfine shifts exhibit a measurable depen... |
41853698 | Selenotrisulfide delivery restores redox balance in myocardial infarction via a thiol-exchange reaction <i>in situ</i>. | The enzyme activity of redox-related selenoproteins is impaired post-tissue injury or inflammation, exacerbating oxidative stress and apoptosis. In this study, we present a strategy using selenotrisulfide (STS) to enhance the selenium content and restore selenoprotein-like activity <i>in vivo</i> via thiol-exchange rea... |
41853699 | Targeting the osteoporotic bone microenvironment: Mechanistic insight and therapeutic biomaterials for accelerating bone regeneration. | Osteoporotic bone defects (OBD) present a major clinical challenge, largely due to a pathological bone microenvironment that severely compromises regenerative capacity. Moving beyond conventional classification schemes that often fail to capture this pathological complexity, our review establishes a conceptual framewor... |
41847379 | Reconstruction of Axonal Projections of Single Neurons Using PointTree. | The morphology of single-neuron axonal projections is critical for deciphering neural circuitry and information flow in the brain. Yet, manually reconstructing these complex, long-range projections from high-throughput whole-brain imaging data remains an exceptionally labor-intensive and time-consuming task. Here, we d... |
41833410 | Electrochemical discrimination of phenylalanine enantiomers in blood using an ATO-γ-CD nanocomposite-modified SWCNT platform. | <h4>Background</h4>The biological sciences and medical disciplines demand the development of an electrochemical approach for enantiomer identification that is both efficient and easy. Phenylalanine enantiomers, require sensitive and selective discrimination due to their distinct physiological roles. Electrochemical met... |
41828848 | MOF-Derived Carbon-Anchored Cu<sub>2</sub>Se/MnSe Heterointerfacial Nanoparticles for Enhanced Lithium Storage via Synergistic Interface Effects. | To address the inherent limitations of Cu<sub>2</sub>Se as a lithium-ion battery (LIB) anode, a Cu<sub>2</sub>Se/MnSe@C composite was rationally designed and synthesized via selenization of a CuMn bimetallic metal-organic framework (MOF) precursor. This synthesis strategy integrates carbon composite engineering and het... |
41823780 | Stimuli-Responsive Hydrogels: From Swelling-Deswelling Mechanisms to Biomedical Applications. | Stimuli-responsive hydrogels, also referred to as "smart" hydrogels, have emerged as versatile platforms for a wide range of biological and biomedical applications owing to their tunable physical, chemical, and biocompatible properties. Their adaptability arises from both their ability to undergo reversible swelling-de... |
41822872 | Post-translational modifications of silk proteins. | Post-translational modifications (PTMs) endow silk proteins with chemical diversity that governs their higher-order assembly, hydration, and covalent connectivity. This review highlights the principal PTMs that define silk protein function, including hydroxylation, glycosylation, phosphorylation, and covalent crosslink... |
41815415 | Biomimetic nanoparticles in cancer photodynamic therapy: a review of targeted delivery systems and therapeutic outcomes. | Photodynamic therapy (PDT) is a minimally invasive cancer treatment that uses photosensitizers (PSs) activated by light to produce cytotoxic reactive oxygen species (ROS). Although PDT shows clinical promise, its effectiveness is limited by factors such as insufficient tumor targeting, tumor hypoxia, PS instability, an... |
41810045 | Single-Molecule Imaging and Spectroscopy Enables Quantification of Location-Dependent Light-Matter Interactions on Nanoantennas. | Individual dye molecules coupled to a plasmonic nanoantenna have been established as a versatile foundation for single-molecule studies. Crucial parameters such as fluorescence intensity enhancement, spectral properties, and emission patterns sensitively depend on the exact position of the dye molecule relative to the ... |
41809558 | Non-covalent assembly-enabled selectivity in aqueous microdroplets. | In microdroplets, various reactions are known to be accelerated. Yet, controlling chemoselectivity within droplets remains largely unexplored. Here, we show that non-covalent self-assembly in sprayed microdroplets enables selective, catalyst-free, ambient-temperature hydrogenation of multifunctional biomass-derived mol... |
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