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41738980 | Pure Chitosan Microfluidic Spinning Affords Modular Core-Sheath Fibers and Hand-Crafted Scaffolds with Enhanced Fibroblast Compatibility. | Microfluidic-spun hydrogel fibers are appealing for tissue engineering and cell transplantation applications, as they give access to fiber-shaped tissues that mimic blood vessels, muscle fibers, or neural networks in vivo. Alginates are overwhelmingly employed as their base material, as they allow for simple processing... |
41738984 | Photo-Modulated Proton Transport in Merocyanine Metastable-State Photoacid Based Polymers. | We demonstrate here that light can be used to modulate proton transport in polymeric soft materials using a polymerizable molecular photoswitch. To this end, we design a merocyanine metastable-state photoacid, which we use as a building block to prepare a series of light-responsive polymers. We confirm the metastable c... |
41738524 | Guest-Induced Activation of Multicolor Photoluminescence in Naphthalene Bisimide Liquid Crystals. | Achieving color- and lifetime-tunable emission in processable materials remains challenging, as most of the available advanced materials systems exist only in impractical solutions or hard-to-process crystals. Liquid crystals (LCs) represent a promising platform due to their processability, though previous work has mai... |
41738516 | Top-Down Exfoliation of Ultrathin Chiral 2D Nanosheets for High-Resolution Gas Chromatography. | Compared with bulk crystal materials that have limitations such as high mass transfer resistance and insufficient exposure of surface action sites, the development of ultrathin two dimensional nanosheets is more attractive. Developing chiral stationary phases with both structural stability and high enantioselectivity r... |
41738501 | A Closed-Loop Chemical Reaction Network for Autonomous, Dual-Window Temporal Programming From a Single Fuel Pulse. | Living systems routinely translate single transient inputs into multi-phase programs of action. To emulate this, we report a closed-loop chemically fueled reaction network (CRN) based on N-benzoyl-l-cysteine methyl ester-N-methylpiperazine dithiocarbamate (DTC) that converts one fuel pulse (dithiothreitol (DTT)) into t... |
41738432 | Influence of Structural Determinants on Dihydrogen Adsorption and Isotopologue Separation in Nanoporous Metal-Organic Frameworks. | Efficient separation of dihydrogen isotopologues, particularly D<sub>2</sub>, is critical for applications in nuclear energy technology and environmental sciences. Conventional methods, such as cryogenic distillation, are energy-intensive and provide limited selectivity (S ≈ 1.4). Here, we report a systematic evaluatio... |
41738382 | DNA Framework-Encoded Digital Recorder for Bacterial Discrimination. | The ability to discriminate multiple biomolecular signals simultaneously is critical for accurate diagnosis of coinfections and evaluation of the medical environment. Yet, achieving multichannel enumeration within a single recording unit remains a significant challenge. Here, we develop a DNA framework-based positional... |
41736701 | Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction. | Hydrogels represent a transformative solution for corneal pathologies, offering the advantages of transparency, biocompatibility, and structural tunability to address the global donor tissue shortage. This review establishes a comprehensive framework for material design by delineating critical requirements, including o... |
41736700 | Peptide Receptor-Functionalized AuNP-Embedded Zwitterionic Biopolymeric Nanohydrogel for Electrochemical Sclerostin Sensing. | Sclerostin (SOST) is a key negative regulator of bone formation and an emerging biomarker associated not only with osteoporosis but also with chronic kidney disease. Despite its growing clinical relevance, biosensing platforms for SOST remain limited, with most existing approaches relying on antibody- or aptamer-based ... |
41736681 | A Quinoidal Two-Dimensional Metal-Organic Framework for High-Performance Micro-Supercapacitors and Solid-State Lithium Batteries. | Two-dimensional (2D) metal-organic frameworks (MOFs) integrating redox-active linkers enable dense charge sites and open ion pathways for microscale energy storage. We report a quinoidal dicarboxylate ligand, AQM-H<sub>2</sub>L, derived from p-azaquinodimethane, forming crystalline frameworks with Cu<sup>2+</sup> and Z... |
41736677 | Engineering Dynamic Proton "Hubs" in Hydrogen-Bonded Frameworks for Superprotonic Conductivity. | Mimicking the synergistic proton conduction in biology remains a formidable challenge for synthetic materials. Here, we report a strategic approach by engineering dynamic proton "hubs" within hydrogen-bonded organic frameworks (HOFs). These hubs are supramolecular secondary building units (SSBUs) formed by charge-assis... |
41736669 | Bioinspired Microreactor for Iodide Adsorption and Photooxidation Recovery. | Iodine, an indispensable element for both industry and biology, suffers from scarcity in the earth's crust and inefficiency in conventional recovery technologies. Herein, inspired by the iodide oxidation pathway in thyroid follicular lumens, we designed a bioinspired micro-ionic-reactor based on a porous organic polyme... |
41736634 | A Cooperative Structural Dimension and Clusters Chirality in Antimony Halide Hybrids for Efficient Circularly Polarized Electroluminescence. | Chiral metal-halide materials often suffer from inherent trade-off between photoluminescence efficiency and chiroptical asymmetry (g value); low-dimensional structures typically deliver high emission efficiency but small g values, whereas higher-dimensional counterparts afford larger g values at the cost of reduced lum... |
41735673 | Design of functionalized C-N-linked fused oxadiazole-azoles and tetrazole backbones as high-energy-density materials. | <h4>Context</h4>Developing high-energy density materials is crucial yet challenging. Designing and evaluating these compounds to find promising candidates is essential. This research used density functional theory to generate energetic compounds based on functionalized C-N-linked fused oxadiazole-azoles and tetrazole b... |
41735249 | Antiviral drug discovery and development: challenges and future directions. | The coronavirus disease 2019 (COVID-19) pandemic has stimulated extensive endeavors toward the development of therapeutic interventions targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human proteins for viral infection control, encompassing numerous potential drugs and thousands of patients p... |
41725526 | Analyses of receptor binding specificity of highly pathogenic avian influenza A (H5N1) viruses isolated from felines in South Korea, 2023. | Influenza viruses infect host cells by binding to specific sialic acid receptors present on the surface of target cells, and this receptor binding exhibits specificity depending on cell type and host species. Avian influenza A (H5N1) viruses typically bind preferentially to α2,3-linked sialic acid receptors, although s... |
41676874 | OER trends on TiO<sub>2</sub> anatase hydroxylated surfaces: a DFT study. | As there are scarce studies on the effect of TiO<sub>2</sub> hydroxylated surfaces on the OER, this study provides a systematic investigation using density functional theory (DFT) calculations for the six degrees of hydroxylation and the oxygen coverage on each anatase (100) and (101) surface. Possible changes in mecha... |
41676871 | Molecular dynamics simulation of self-assembly of one-component nanocrystals grafted with end-functionalized polymers. | The self-assembly of polymer-grafted nanocrystals (PGNCs) is an important approach to construct new nanomaterials with tunable properties and novel applications, which has attracted considerable attention recently. Introducing functional groups at the ends of polymer chains is an attractive strategy for the self-assemb... |
41666398 | Morphology control of stimulus-responsive fluorescence-enhanced supramolecular aggregates based on pillar[5]arenes. | The rational functionalization of pillar[<i>n</i>]arenes enables unprecedented properties, establishing it as a pivotal strategy for constructing advanced functional materials. In this study, we synthesized a series of asymmetrically functionalized pillar[5]arene derivatives H1, H2, and H3, whose molecules were termina... |
41665034 | Supramolecular engineering of an azelaic acid-nicotinamide cocrystal for dual anti-inflammatory and brightening efficacy. | An [AzA][Nic] cocrystal was engineered through supramolecular synthon design between azelaic acid ([AzA]) and nicotinamide ([Nic]) to overcome intrinsic [AzA] bioavailability limitations. Single-crystal X-ray analysis and DFT calculations revealed that the N1⋯O4-H4 hydrogen bond and electrostatic complementarity drive ... |
41661554 | CO<sub>2</sub>, N<sub>2</sub> and H<sub>2</sub> adsorption in Zn<sup>2+</sup>-containing zeolites and metal-organic frameworks. | We employ a chemically accurate (±4 kJ mol<sup>-1</sup>) embedding approach to calculate enthalpies for CO<sub>2</sub>, N<sub>2</sub>, and H<sub>2</sub> adsorption in the Zn<sup>2+</sup>-containing zeolites FAU and CHA, and for CO<sub>2</sub> and H<sub>2</sub> in the metal-organic frameworks (MOFs) Zn-MOF-74 and CALF-2... |
41649222 | A biomimetic phage-inspired supramolecular system based on glucose-conjugated pillar[5]arene with ciprofloxacin hydrochloride. | Self-assembling phage-inspired carriers based on macrocyclic molecules have the potential to overcome antibiotic resistance and extend the antimicrobial effect of drugs. In this study, we have synthesized a new water-soluble pillar[5]arene containing thioglycoside fragments. This compound had an affinity for a model li... |
41646013 | Halide perovskite scintillators for X-ray detection: from structure to engineering. | Halide perovskites (HPs) and their derivatives are emerging as a prominent class of materials for ionizing radiation detection. A unique combination of high atomic numbers, efficient luminescence, tunable optoelectronic properties, defect tolerance and low synthesis cost positions them as a promising alternative to tra... |
41646001 | Highly stable, luminescent gold nanocluster assemblies driven by depletion and covalent linker interactions. | Supramolecular assembly of ultra-small, metal nanoclusters (NCs) offers a versatile platform to modulate their environment-dependent physicochemical properties; however, achieving structural control together with high thermodynamic stability remains challenging due to weak and dynamic noncovalent interactions. Herein, ... |
41641728 | Controlled packing of metal-peptide superhelices with β-peptide foldamers. | Metal-peptide superhelices formed from 12/10-helical β-peptide foldamers exhibit programmable hierarchical assembly. A single metal-coordinated superhelix organizes into distinct parallel or antiparallel arrangements without conformational distortion. This adaptability arises from a minimized macrodipole and dynamic fo... |
41636166 | Molecular interactions of cinnamyl and quinoxaline derivatives with Bcl-2 antiapoptotic proteins: a computational study. | Antiapoptotic proteins represent a major obstacle to the success of anticancer therapies, as they promote the survival of malignant cells and contribute to treatment resistance. Among these, Bcl-2 and Bcl-xl are frequently overexpressed in pancreatic cancer, making them important therapeutic targets. In this work, we p... |
40718961 | The development of <i>Burkholderia</i> bacteria as heterologous hosts. | Covering up to 2024Drug resistance is a serious and growing problem, and new small molecules are needed for a wide variety of clinical and agricultural applications. Natural products, encoded by biosynthetic gene clusters, have consistently been a source of chemical diversity for finely tuned interactions with a range ... |
41902186 | Hepatitis D Virus Pathogenesis: A Sense of Complications. | Hepatitis D virus (HDV) is a satellite RNA virus of the hepatitis B virus (HBV) infecting an estimated 12 million people worldwide. Chronic HDV infection is causing the most severe form of chronic viral hepatitis, leading to a rapid progression of chronic inflammation to fibrosis, cirrhosis, liver decompensation and ca... |
41900886 | Nanoengineered γ MnO<sub>2</sub> Accelerates the Degradation of Antibiotic-Resistant Biofilms. | Bacterial biofilms remain a major challenge in clinical infections due to their dense extracellular polymeric substance (EPS) matrix and strong resistance to conventional antibiotics. This study reports manganese dioxide (MnO<sub>2</sub>) nanoparticles capable of autonomous navigation toward bacterial clusters, mechani... |
41900769 | Anatomically Guided Non-Viral CRISPR/Cas9 Delivery in the Eye: Overcoming Barriers for Precision Gene Therapy. | <h4>Background/objectives</h4>While CRISPR/Cas9 technology offers a revolutionary approach for correcting genetic ocular blindness, efficient and safe delivery remains the primary bottleneck. Traditional viral vectors, despite their efficacy, face challenges regarding cargo size limitations and potential genomic integr... |
41900770 | Microbiome-Responsive Hydrogels: From Biological Cues to Smart Biomaterials. | <b>Background:</b> Stimuli-responsive hydrogels (SRHs) are smart polymeric materials that undergo reversible physicochemical changes in response to abiotic cues and externally applied fields, enabling applications in drug delivery, wound healing, and tissue engineering. However, they exhibit limited biological specific... |
41897424 | Mitochondrial Impairment in Unloaded Postural Muscle: Mechanisms Driving Loss of Muscle Function and Mass. | Mechanical unloading of skeletal muscle triggers various signaling alterations that result in muscle atrophy and weakness. Mitochondria are essential to muscle health, acting not only as energy suppliers but also as central mediators of molecular regulation. Mitochondrial activity, content, and dynamics are tightly con... |
41897422 | Nox1-Derived ROS Amplifies Calcium Entry and Enhances Pneumolysin-Induced Lung Endothelial Barrier Dysfunction in Hyperglycemia. | <b>Background:</b><i>Streptococcus pneumonia</i> is the primary etiological agent of community-acquired pneumonia (CAP). Pneumococci promote severe lung injury through the release of virulence factors, including pneumolysin (PLY). Obesity/diabetes increases pneumonia-associated mortality, but the mechanisms remain elus... |
41895117 | Locking in flavor: Aroma chemistry and spray drying encapsulation strategies for stable food applications. | Flavors and aromas are essential to food quality, but their volatility and chemical reactivity make them highly susceptible to loss during processing and storage. Spray drying is the most widely used and scalable technique for encapsulating food flavors, converting unstable liquid aromas into stable, free-flowing powde... |
41894888 | Development of a magnetic solid phase extraction method using a molecularly imprinted polymer@magnetic bimetallic metal-organic framework nanocomposite for the extraction of acetamiprid pesticide from honey samples. | In this study, a nanocomposite based on MIP@ZrZnMOF@Fe₃O₄ has been synthesized and employed as a sorbent in magnetic solid phase extraction method performed in a narrow bore tube. The suggested method is used for the extraction of acetamiprid from commercial honey samples before its quantification with liquid chromatog... |
41893264 | Unveiling the Heterogeneity and Multifunctions of Biological Membranes: A Unifying Perspective in Membrane Biophysics from Molecular Coupling to Cellular Function. | Biological membranes are the quintessential functional interface of life, where lipid bilayer mechanics, compositional heterogeneity, and dynamic protein interactions converge to govern cellular physiology [...]. |
41893163 | Biodistribution and Biodegradation of an Osteoinductive Supramolecular Polymer Implant in a Rat Spinal Fusion Model. | Recombinant human bone morphogenic protein-2 (rhBMP-2) use in spinal fusion is limited by dose-dependent complications. Peptide amphiphile (PA) supramolecular polymers presenting a BMP-2-binding epitope have previously been developed to reduce the rhBMP-2 dose required for successful fusion. We evaluated PA implant bio... |
41892948 | Fabrication and Functional Modification Strategies of Squid Ink-Derived Nanoparticles: From Natural Melanin to Multifunctional Biomaterials. | Squid ink has recently garnered considerable attention as a natural melanin source for the development of biocompatible nanomaterials. Although numerous studies have explored the biological and therapeutic applications of squid ink, the fabrication and modification strategies for squid ink-derived nanoparticles (SINPs)... |
41892512 | Quantitative Assessment of Hydrogel Printability in Extrusion Bioprinting. | Extrusion-based 3D bioprinting enables the fabrication of complex tissue structures, yet achieving both high structural fidelity and cell viability remains challenging due to complex bioink rheology and parameter interplay. This review presents a quantitative framework linking hydrogel properties to printing outcomes. ... |
41892510 | Recent Progress and Morphological Distribution of Polydopamine-Based Biomaterials and Their Applications. | Polydopamine (PDA) is a bioinspired polymer known for its strong adhesiveness, biocompatibility, and functional properties, making it highly useful in biomedical applications. This review highlights recent progress in PDA-based biomaterials, with a focus on their morphology, synthesis techniques, and various biomedical... |
41890808 | TCRLens: structure-aware equivariant graph learning for TCR-pMHC-I recognition and immunogenic epitope discovery. | <h4>Motivation</h4>Accurate prediction of T-cell receptor (TCR) recognition of peptide-MHC class I (pMHC-I) complexes is a key challenge due to structural diversity and data sparsity. We introduce TCRLens, a structure-aware deep learning framework that models residue-level interactions across five critical interface zo... |
41889759 | Poly(arylene-ethynylene)s in Synthetic Heterogeneous Visible Light Photocatalysis: Structure-Reactivity Principles and Opportunities in Flow. | Visible light photocatalysis has reshaped synthetic organic chemistry by enabling mild and selective radical processes. However, its widespread adoption is still constrained by the reliance on homogeneous photocatalysts, typically precious-metal complexes or organic dyes, which complicate recovery, recyclability, scala... |
41867407 | Real-Time Acetone Gas Monitoring Using Calixarene-Functionalized Guided-Mode Resonance-Based Sensors. | Portable sensors to detect volatile organic compounds (VOCs) are needed for many societal and industrial applications, such as diagnosing patient health through breath analysis or monitoring industrial environments for worker safety. Acetone, a widely used industrial solvent, is an important example that requires sensi... |
41835527 | <i>De Novo</i> Drug Design, Synthesis, Biological Evaluation, and Structural Examination of Novel Coumarin-Based Pyrimidine Co-Drugs Accompanied by Molecular Docking and DFT Studies. | In this research, we synthesized novel coumarin-pyrimidine hybrid molecules and studied their antioxidant properties by using the DPPH radical scavenging assay. Different computational techniques (3DQSAR, pharmacophore modeling, molecular docking, MMGBSA, and ADMET) were used to validate the synthesized compounds furth... |
41835453 | Folded-state compatibility and unfolded-state constraint govern staple-based stabilization: guidelines from a coiled-coil model. | Peptide stapling has emerged as a powerful strategy for stabilizing protein conformation, improving proteolytic resistance, and enhancing biomolecular recognition. Yet design principles for selecting staple sites remain elusive, so advances in stapling have depended largely on trial and error. Here we establish quantit... |
41835451 | Bifunctional glycolipids targeting TLR4·MD-2 and short pentraxins. | Innate immune detection of pathogen- and danger-associated molecular patterns (PAMPs/DAMPs) centres on pattern-recognition receptors, with the TLR4/MD-2 complex being uniquely sensitive to trace levels of lipopolysaccharide (LPS) as well as infection-triggered endogenous ligands. While this axis rapidly induces protect... |
41835081 | Ni- and Zn-Doping Effects on Cu/SiO<sub>2</sub> Catalysts in Nonoxidative Ethanol Dehydrogenation. | Nonoxidative ethanol dehydrogenation opens a pathway for the sustainable production of acetaldehyde and butadiene. One crucial aspect of producing butadiene by the Lebedev process is the high-temperature stability of ethanol to acetaldehyde conversion. However, copper-based catalysts, despite exhibiting high activity a... |
41823741 | Metal-Decorated C<sub>8</sub> Quantum Dots as Lightweight Hydrogen Storage Materials: A Comprehensive DFT Study. | Lightweight, efficient, and reversible hydrogen storage materials are critical for the advancement of hydrogen-based energy technologies. In this work, we present a comprehensive density functional theory (DFT) investigation of hydrogen storage in pristine and metal-decorated C<sub>8</sub> carbon quantum dots (CQDs), r... |
41823740 | Density Functional Theory Insights into Polypyrrole-Based Functional Composites for Advanced Energy Storage, Sensing, and Environmental Applications. | Polypyrrole-based functional composites are increasingly explored and extensively adopted for energy storage, sensing, and environmental applications due to their tunable electronic properties, chemical versatility, and mechanical stability. However, rational optimization of these composites requires a unified understa... |
41816692 | Dual-probe genome mining identifies citrulassin N, a novel citrulline modified lasso peptide from <i>Streptomyces</i> sp. NAX00255. | <h4>Introduction</h4>Lasso peptides are a structurally distinctive class of ribosomally synthesized and post-translationally modified peptides (RiPPs) featuring a threaded rotaxane topology that confers remarkable thermal stability and protease resistance. Citrulassins represent a rare subgroup of lasso peptides distin... |
41816686 | Breaking the outer membrane barrier: structure, targets, and antimicrobial strategies for Gram-negative bacteria. | Multidrug resistance in Gram-negative bacteria has become a significant global public health challenge, threatening human health and clinical treatment outcomes. The unique outer membrane structure of these pathogens greatly limits antibiotic penetration, serving as the core mechanism of resistance. This paper systemat... |
41816329 | The role of programmed cell death 1 in autoimmune diseases: mechanisms and therapeutic implications. | Autoimmune diseases are complex disorders caused by the interaction between the immune system and self-antigens, involving genetic, environmental triggers, and other cellular factors. The programmed cell death receptor-1 (PD-1) gene, as a critical factor in immune regulation, has garnered significant attention in the s... |
41815908 | Nanomaterial-mediated modulation of gut microbiota for precision diagnosis and treatment of colorectal cancer: a comprehensive review. | The critical role of gut microbiota in the initiation and progression of colorectal cancer (CRC) has garnered widespread recognition. Leveraging their precise targeting capabilities and programmable properties, nanomaterials are emerging as novel strategy for modulating the interplay between microbiota and tumors. This... |
41815862 | PMPCylated liposomes in drug delivery and beyond. | Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) is a zwitterionic polymer that mimics phosphatidylcholine headgroups of cell membrane, exhibiting excellent biocompatibility and antifouling properties. Recently, PMPCylated liposomes, i.e., liposomes functionalized with PMPC chains, have emerged as promising nanoca... |
41800458 | Click-chemistry hydrogel for blood vessel organoids self-sustaining delivery to enhance flap survival. | Insufficient vascularization and ischemic stress severely limit flap survival in reconstructive surgery. To address this challenge, we developed a glucose-releasing hydrogel-encapsulated vascular organoid system (GL@BVOs) that integrates metabolic support with organoid-based therapy. The hydrogel integrates a photocros... |
41799521 | Next Generation DNA Damage Response Inhibitors: Harnessing Nanocarriers and Tumor Microenvironment for Precision Cancer Therapy. | Tumor survival, genomic stability, and therapy resistance are dictated by the DNA damage response (DDR). Although poly (ADP-ribose) polymerase (PARP) inhibitors have established the DDR as a therapeutic target, many tumors evade first-generation drugs by rewiring their adaptive repair pathways and imposing microenviron... |
41799503 | Research on the Mechanism of "Cold Tumor" Formation and Immunotherapy for Its Transformation into "Hot Tumor". | A clear goal in cold tumor research is to identify strategies for converting them into immunologically 'hot' tumors with enhanced immune cell infiltration and activity, thereby improving their responsiveness to immunotherapy. The genesis of cold tumors is exceedingly intricate. In recent times, as the analysis of this ... |
41799502 | Put the CAR-T before the HRS: Advances in Anti-CD30 Immunotherapy Targeting Hodgkin/Reed-Sternberg Cells in Classical Hodgkin Lymphoma. | Classical Hodgkin lymphoma (cHL) is characterized by rare Hodgkin/Reed-Sternberg (HRS) tumor cells that uniformly express cluster of differentiation (CD)30 molecules and orchestrate an immunosuppressive tumor microenvironment, making CD30 an attractive and selective therapeutic target. We summarize the biological ratio... |
41799322 | Bis{μ-1,3-bis-[dimeth-yl(pyridin-3-yl)sil-yl]propane-κ<sup>2</sup> <i>N</i>:<i>N</i>'}bis-[di-iodido-zinc(II)] from synchrotron data. | The structure of the title compound, [Zn<sub>2</sub>I<sub>4</sub>(C<sub>34</sub>H<sub>52</sub>N<sub>4</sub>Si<sub>4</sub>)<sub>2</sub>], has been determined from synchrotron data, λ = 0.70000 Å. The complete metallacyclic mol-ecule is generated by crystallographic inversion symmetry, with the Zn<sup>II</sup> ion locate... |
41799258 | Development of highly robust selenium nanoparticles in food matrix based on polysaccharide stabilization mechanism. | The rational selection of stabilizers for selenium nanoparticles (SeNPs) is hindered by a lack of mechanistic understanding. Accordingly, this study investigated the deeper polysaccharide-based stabilization mechanism by comparing the effects of linear pullulan polysaccharide (PP), branched amylopectin starch (AS), and... |
41785635 | Hierarchical MOFs with spatially ordered cascade enzymes for sensitive nitrite immunosensing. | Enhancing the bioactivity and utilization efficiency of immobilized enzymes is essential for the construction of sensitive immunosensors. However, conventional approaches are often limited by random enzyme spatial distribution, which compromises cascade efficiency. Here, we constructed a multilayer metal-organic framew... |
41783797 | Enantioselective synthesis of allylic boronates bearing a stereodefined (<i>E</i>)-alkenyl chloride by Cu-catalyzed borylation of allylic <i>gem</i>-dichlorides. | Chiral α,γ-substituted allyl boron reagents are valuable tools in organic synthesis. However, asymmetric catalytic strategies for synthesising this type of compound bearing a stereodefined alkenyl chloride are underdeveloped. Here we report a copper-catalyzed enantioselective borylation of allylic <i>gem</i>-dichloride... |
41783267 | All-SAM interfacial architecture for perovskite solar cells without charge transport materials. | State-of-the-art perovskite solar cells (PSCs) employ a multilayer device structure, incorporating a combination of charge transport layers and interfacial modifications to achieve efficient charge extraction. However, simplifying the device structure is highly desirable for cost-effective mass production. One approach... |
41782994 | Ultrasound-activated dual-targeted liposomes for visualized precise neuromodulation against myocardial ischemia-reperfusion injury. | Myocardial ischemia-reperfusion (I/R) injury remains a critical clinical challenge with limited effective treatments. Sympathetic hyperactivation and microglia-mediated neuroinflammation in the paraventricular nucleus exacerbate myocardial I/R injury. Whilst previous studies suggest that sonodynamic neuromodulation has... |
41777710 | Decoding the unseen: unsupervised anomaly detection in metal-organic frameworks for discovery beyond the norm. | The discovery of chemically novel or structurally anomalous metal-organic frameworks (MOFs) is essential for expanding reticular design space and enhancing dataset reliability. We present CHEM-AD (Chemically Unusual Metal-organic Frameworks <i>via</i> Autoencoder-based Detection), a label-free, CPU-efficient pipeline t... |
41777241 | Computational screening of piezoelectric constants in metal-organic frameworks: design principles and ferroelectric-like bond modulation. | Piezoelectric energy harvesting is a process in which energy in the form of kinetic movements can be harvested and converted into useful electrical energy using piezoelectric materials. Metal-organic frameworks (MOFs) have a huge potential for piezoelectric energy harvesting owing to their high flexibility, structural ... |
41768394 | Biomimetic Nanoparticles for Targeted and Efficient Cancer Therapy: Progress, Challenges and Perspectives. | Cancer remains a prominent cause of global mortality, with over 200 identified forms, and is projected to have a 25% increase in fatalities by 2030. Early diagnosis and treatment are crucial, but current therapy, which includes surgery, chemotherapy, immunotherapy, hormonal therapy, targeted therapy, and radiotherapy, ... |
41768395 | Ferroptosis-Like Death: An Emerging Innovative Antibacterial Strategy. | The increasing global crisis of antibiotic resistance underscores the imperative for innovative antibacterial strategies that transcend conventional mechanisms. Ferroptosis, an iron-dependent form of regulated cell death characterized by lethal lipid peroxidation, is a promising therapeutic approach. This review system... |
41768139 | Zoon0PredV: Potential Virus Species Crossover Prediction Using Convolutional Neural Networks and Viral Protein Sequence Patterns. | Biomedical science has made substantial progress toward diagnosing, understanding the pathogenesis, and treating various causative agents of infectious disease. However, novel microbial pathogens continue to emerge, and existing pathogens continue to evolve alternative strategies to thrive in ever-changing environments... |
41763127 | Preparation of a cucurbit[6]uril-containing monolithic material for specific recognition and enrichment of multi-phosphopeptides. | Supramolecular affinity chromatography based on host-guest interactions represents a promising approach for achieving highly specific separation and purification of biomacromolecules. Among the various macrocyclic molecules, cucurbit[n]urils (CB[n]) have attracted significant attention in recent years due to their uniq... |
41762887 | crRNA-engineered CRISPR/Cas12a system coupled with RPA for ultrasensitive detection of Lactiplantibacillus plantarum. | The growing probiotic industry requires rapid and precise strain detection methods. Here, a one-pot fluorescence platform integrating RPA with an enhanced CRISPR/Cas12a system (termed RPA-ECas12a) was developed for the detection of Lactiplantibacillus plantarum. Through rational 5'end DNA extension of the crRNA, an opt... |
41756253 | RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets. | Cancer is a global health challenge. The initiation and progression of cancer are correlated with dynamic dysregulation of RNA regulatory networks. This review systematically explains how contending RNAs (including mRNA, miRNA, lncRNA, circRNA, etc.) remold gene expression programs across multiple dimensions. They do t... |
41747916 | Identification and expression analysis of scavenger receptor SCARA4 in Nibea albiflora. | Nibea albiflora is often infected by pathogens of Larimichthys crocea and other adjacent net-caught fish during the cage culture process, which brings great harm to its culture process. Scavenger receptors (SRs) are a class of membrane-anchored glycoproteins that play an essential role in innate immunity. In this study... |
41747347 | Membrane-anchoring engineering mediated the self-assembly of multifunctional nanocarriers: An efficient platform for astaxanthin delivery. | To overcome the instability of astaxanthin (AST) during processing and gastrointestinal delivery, this study developed a multifunctional nanocarrier through the precise self-assembly of lipid bilayers that incorporated d-α-tocopherol polyethylene glycol 1000 succinate, a widely used biocompatible surfactant known as TP... |
41743938 | Exploring the advances in 2D materials as a quest for energy storage electrode materials. | The increasing demand for effective energy storage solutions has spurred research into innovative materials with exceptional properties. Among these, two-dimensional (2D) materials have become popular alternatives due to their unique mechanical, chemical, and electrical characteristics. This review highlights recent ad... |
41743850 | Antimicrobial Peptides as Cross-Seeding Modulators at the Neurodegenerative-Infectious Interface. | Antimicrobial peptides (AMPs), traditionally regarded as innate immune effectors, are increasingly recognized for their structural and functional convergence with pathogenic amyloids. Recent studies-including our own-reveal that AMPs not only exhibit antimicrobial activity but also modulate amyloid aggregation by accel... |
41743849 | Advancing Gene Therapy for Pancreatitis: From Genetic Insights to Clinical Translation. | Pancreatitis is a complex inflammatory disease with substantial genetic determinants. It progresses from acute to chronic forms and poses substantial clinical challenges due to a lack of disease-modifying therapies. Conventional treatments are largely palliative, highlighting the urgent need for mechanism-based interve... |
41740406 | Artificial bio-cables of carbon fiber filaments bridge microbial electron flow and hydrocarbon degradation in soil. | Low extracellular electron transfer (EET) efficiency and limited synergistic interactions of functional microbes are bottlenecks of in-situ bioremediation of petroleum hydrocarbon-contaminated soils. In this study, carbon fibers were used as conductive mediators to construct long-term "artificial bio-cable" in soil for... |
41743935 | Synthesis and zero-dimensional structure of a new lead-free organic-inorganic[(C<sub>2</sub>H<sub>5</sub>)<sub>4</sub>N]<sub>3</sub>Bi<sub>2</sub>I<sub>9</sub> compound: a promising material for optoelectronic devices. | A new lead-free organic-inorganic hybrid compound based on Bi(iii), namely tris(tetraethylammonium)nona-idodibismuthate(iii), [(C<sub>2</sub>H<sub>5</sub>)<sub>4</sub>N]<sub>3</sub>Bi<sub>2</sub>I<sub>9</sub>, has been successfully synthesized using a slow evaporation technique. The compound was characterized by single... |
41743943 | Selective recovery of silver by thiuram disulfide-modified cellulose. | A thiuram disulfide-modified cellulose adsorbent (TDMC) was developed for the highly selective recovery of silver ions from aqueous solutions. The adsorbent was synthesized by introducing thiuram disulfide functional groups onto a cellulose backbone to selectively adsorb Ag(i). Batch adsorption experiments were conduct... |
41743859 | Ag-Decorated Hydrogen Molybdenum Bronze Nanotubes as Dual-Action Agents Against <i>Bacillus subtilis</i>: Experimental and Theoretical Insights Into Membrane Damage and Protein Interference. | Bacterial biofilms are a persistent challenge in industrial settings such as water treatment and food processing, contributing to antimicrobial resistance, operational inefficiencies, and environmental burden. Here, we report on the synthesis and multiscale evaluation of hydrogen molybdenum bronze nanosheets (HMB-NSHs)... |
41743848 | Origin of Single-Molecule Reaction Chirality. | The origin of molecular chirality remains an enigma in chemistry, particularly regarding how single-molecule events overcome intrinsic stochasticity to establish population-level chirality. Here, we present a viable strategy for real-time, from-the-beginning single-molecule trajectory monitoring of asymmetric evolution... |
41736223 | Proton-Conducting 3D Polyoxoniobate Supramolecular Frameworks via Exclusive Guanidinium and Synergistic 4p-4f Metal-Oxo Clusters. | A strategy focusing on framework stability and proton-conducting hydrogen-bonding networks in polyoxoniobates (PONbs) has been implemented, wherein protonated organic amines act as exclusive counter cations, synergistically enhanced by embedded 4p-4f metal-oxo clusters. This approach yields a new family of three-dimens... |
41736191 | Chiral Plasmonic Nanostructures: Advances in Synthesis and Bio-Detection Applications. | Chirality is a defining feature of life, embedded not only in the structures of amino acids, saccharides, proteins, and nucleic acids but also in their stereoselective interactions, such as protein-ligand binding, enzyme catalysis, and nucleic acid recognition. Abnormal changes in chiral structures are increasingly rec... |
41736107 | Programmable trivalent nanocage vaccine confers durable cross-species protection against Bordetella bronchiseptica infection. | Bordetella bronchiseptica (B. bronchiseptica), a respiratory pathogen endemic in companion animals, poses an escalating zoonotic threat to humans due to intensified human-pet contact, particularly among immunocompromised individuals. Here, we report a programmable trivalent nanocage vaccine, mi3-F1P2Fim2, featuring imm... |
41736040 | Chlorine-coordinated iron single-atom nanozymes for amplified ferroptosis in triple-negative breast cancer therapy. | Triple-negative breast cancer (TNBC) represents an aggressive breast cancer subtype with limited therapeutic options and poor prognosis. Although single-atom nanozymes (SAzymes) show promise in cancer therapy, their ferroptosis-inducing capability remains limited. Herein, we present a rationally designed iron-based SAz... |
41735822 | More Than a Buffer in Biochemistry: Tris as an Architect and Gatekeeper of Metal-Oxo Assembly. | Polyoxometalates (POMs, molecular metal-oxo clusters) are typically studied and applied in aqueous media, where routine buffers determine which clusters form, persist, or react. Tris(hydroxymethyl)aminomethane (Tris) is a ubiquitous buffer near physiological pH and has produced outcomes that pH control alone could not ... |
41735763 | Toxicogenomic Characterization of Perfluorooctanoic Acid-Associated Bladder Carcinogenesis. | <h4>Objective</h4>This study aims to bridge toxicological target prediction and bladder cancer transcriptomics by systematically identifying molecular signatures and pathways that converge between PFOA-associated toxicological effects and bladder cancer biology, using an integrative multi-cohort computational framework... |
41735666 | Stabilizing Ni<sup>3+</sup>-Rich NiO<sub>x</sub>/Perovskite Interface via Dual Coordination for Efficient and Durable Perovskite Photovoltaics. | While nickel oxide (NiO<sub>x</sub>) is widely employed as an efficient hole-transport material, the surface Ni<sup>3+</sup> species required for effective transport are unstable and can drive unfavorable interfacial reactions with the perovskite layer. Herein, we introduce a tetraoxopyridine-functionalized porphyrin m... |
41735545 | Multistep metabolic engineering of Pichia pastoris for biosynthesis of N‑acetylneuraminic acid. | Free or protein-conjugated N-Acetylneuraminic acid (Neu5Ac) is widely distributed in organisms and possesses diverse biological functions, and for example lactoferrin with Neu5Ac-mediated sialylation exhibits significantly enhanced functional activity compared with non-sialylated lactoferrin. Pichia pastoris serves as ... |
41735450 | Serum programmed death ligand 2 is elevated in cats with mammary carcinoma. | Since the PD-1/PD-L1/PD-L2 axis plays a vital role in immune tolerance and T-cell exhaustion, having emerged as a target for breast cancer immunotherapy, we investigated the relevance of serum PD-L2 (sPD-L2) levels in feline mammary carcinoma (FMC), to validate its potential use as a diagnostic and/or prognostic biomar... |
41735397 | Chemical composition, antioxidant and antimicrobial activities, and molecular docking of Acacia gerrardii leaf extract. | This study aims to investigate the chemical composition, mineral content, antimicrobial and antioxidant activities, and pharmacokinetic properties of the methanolic extract of Acacia gerrardii leaves. Mineral analysis using ICP-AES revealed iron as the predominant element (6.67 mg/g), followed by aluminum (4.70 mg/g) a... |
41735342 | Trimbody with rigid AI-designed scaffolds enables atomic-resolution cryo-EM structure determination of small proteins. | Cryo-electron microscopy (cryo-EM) single-particle analysis faces significant challenges in resolving the structures of small proteins due to low signal-to-noise ratios and insufficient structural features. Here, we present Trimbody, a simple yet robust method that leverages rigid AI-designed scaffolds to overcome thes... |
41735321 | Harnessing a germ‑free mouse gut bioreactor for directed evolution of probiotics to combat non-alcoholic fatty liver disease. | Directed evolution has transformed biomolecular engineering but remains largely untapped for probiotic optimization, despite its immense promise for human health maintenance and disease therapy. Here, we present an in vivo, host-mediated directed-evolution platform that harnesses the gut's endogenous selective pressure... |
41735323 | Chiral inheritance effect in the reactive cystine-based coassembly system. | Controlled chemical reactions in the condensed state are key steps in designing smart materials. Due to the absence of diffusion and sufficient molecular collision, the reaction efficiency in the solid or aggregated state is expectedly much lower than the solution phase. Herein we report the templating effects in self-... |
41735315 | Blunt-force assembly of programmable DNA architectures using π-π stacking. | Sticky-ended cohesion has been the driving force for DNA self-assembly and has enabled model and design programmability in DNA nanotechnology for over 40 years. Traditional units within self-assembled crystals have rationally-designed sticky ends to avoid unpredictable packing behavior, but in doing so, the surprising ... |
41735294 | Machine learning guided resolution of mechanical trade-off in polymer composites via stress adaptive interface. | Developing polymer composites that simultaneously achieve high strength, toughness, and impact resistance remains a fundamental challenge due to inherent trade-offs and brittle interfacial failure. Here, we propose a universal toughening strategy that integrates a bone-inspired trabecular interlock architecture with a ... |
41735269 | Role of lipid rafts in the FGFR2c-mediated oncogenic signaling by involvement of TRPA1 channel in pancreatic ductal adenocarcinoma cells. | The aberrant expression of the mesenchymal FGFR2c variant in pancreatic ductal adenocarcinoma (PDAC)-derived cells enhances EMT and tumorigenic features, with PKCε-dependent signaling emerging as the main downstream pathway involved. Since lipid rafts are specialized microdomains functioning as signaling hubs and consi... |
41735266 | Disordered light-harvesting aggregates can host functional vibronic couplings at room temperature. | Photosynthesis relies on a network of chlorophyll-like molecules which together lead to efficient long-range energy transfer. Evidence at cryogenic temperatures suggests that mechanistic details of energy/charge transfer must invoke coupled vibrational-electronic (vibronic) states. Whether these survive at physiologica... |
41735261 | CREB suppresses PGRP-SC2 to drive age-related immune senescence and gut dysbiosis in Drosophila. | The maintenance of immune homeostasis is critical for tissue health and longevity, yet the regulatory mechanisms linking immune modulation to aging remain poorly understood. Here we found that the transcription factor cAMP response element-binding protein (CREB), activated by JNK signaling in aging guts, transcriptiona... |
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