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41735260 | Colored polymer-reinforced metal-organic framework microparticles with high charge-to-mass ratio for electrophoretic display. | Besides high porosity and controllable structure, metal-organic framework (MOF) has some natural advantages for color electrophoretic particles: easy modification, controllable morphology, low and adjustable density, and high charge density, as well as rich, vivid, and stable colors. Therefore, we first integrated the ... |
41735232 | Defective Engineered Metal-Organic Frameworks for Tumor Cell-Specific Combined Therapy. | Tumor-specific combination therapies have emerged as highly promising strategies in the realm of cancer theranostics, offering the potential for improving therapeutic efficacy. Herein, we developed a hyaluronic-acid-functionalized defective metal-organic framework (Fe-UiO@HA), which serves as an integrated nanoplatform... |
41735013 | Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation. | Rnd3 regulates cellular processes commonly dysregulated in cancer, and altered Rnd3 expression has been linked to several cancer types. Here, we show lung adenocarcinoma patients expressing low levels of Rnd3 have significantly higher survival rates. To gain mechanistic insight into this correlation, we knocked down Rn... |
41734994 | The path forward for T cell engagers in patients with prostate cancer. | T cell engagers (TCEs) recruit T cells to the tumor microenvironment (TME) to induce antitumor immune responses. TCEs have demonstrated promising clinical responses in patients with metastatic castration-resistant prostate cancer and have advanced into phase 3 clinical trials. Here we provide an overview of the mechani... |
41734934 | Ce-Doped and Defect-Engineered Zr-Based MOF Nanozyme with Enhanced Organophosphorus Hydrolase-like Activity for Detoxification and the Dual-Mode Detection of Nerve Agent Simulants. | It is urgently needed to develop a highly efficient sensor that can rapidly degrade and accurately detect extremely toxic nerve agents, considering that intrinsic drawbacks still exist in most reports based on the inhibition of the activity of natural organophosphorus hydrolases (OPHs). Herein, we presented a two-prong... |
41734227 | An intrinsic loop-mediated structural stability modulating inhibitor potency in the SADS-CoV and SARS-CoV-2 main proteases. | Swine acute diarrhea syndrome coronavirus (SADS-CoV) poses a significant zoonotic risk. The absence of the structure of SADS-CoV main protease (Mpro) severely impedes the development of effective antiviral therapeutics. Here, we present the high-resolution structures of SADS-CoV Mpro and its complexes with inhibitors 2... |
41734208 | Integrating intrinsic charge-trapping sites in an insulated MOF nanoparticle-based dielectric layer for effective photo/synaptic transistors. | The design of charge-trapping sites is the basic and critical factor to explore organic photomultiplier phototransistors and synaptic transistors. There are few examples of charge trapping achieved directly by constructing dielectric materials, as the traditional view holds that their wide band gaps make charge trappin... |
41734172 | The synergistic interaction between ACE and TMPRSS2 polymorphisms increases the risk of severe COVID-19. | Within a few years after the pandemic outbreak, several of evidence have found to suggest that the genetic factors influence the severity and mortality rate of COVID-19. In particular, the identification of genetic markers that increase the risk of severe or critical COVID-19 is important for public health management d... |
41733821 | Quantum dot enhanced photonic biosensors for single cell analysis from synthesis to clinical application. | The quantum dot (QD)-enhanced optical biosensors are very sensitive tools for analyzing single cells. Heavy metal-free alternatives, such as indium phosphide and carbon-based QDs, address safety concerns while achieving high quantum efficiency. Photonic enhancement techniques provide 240-fold signal amplification and q... |
41733622 | Chemiresistive Gas Sensors Based on Ni<sub>3</sub>(HITP)<sub>2</sub>/Ti<sub>3</sub>C<sub>2</sub> Heterojunctions for ppb-Level NH<sub>3</sub> Detection at Room Temperature. | In response to the growing demand for efficient NH<sub>3</sub> monitoring in industrial settings, this study reports a novel Ni<sub>3</sub>(HITP)<sub>2</sub>/Ti<sub>3</sub>C<sub>2</sub> hierarchical heterojunction material and fabricated a room-temperature gas sensor based on MEMS technology. Leveraging the high conduc... |
41733570 | Mapping Allosteric Communication in the Nucleosome with Conditional Activity. | The nucleosome core particle (NCP) regulates genome accessibility through dynamic allosteric communication between histone proteins and DNA. Building on the concept of conditional activity introduced by Lin (2016), we use molecular dynamics simulations and develop an open-source Python library, CONDACT (CONDitional ACT... |
41733500 | Stabilities of Ac<sup>3+</sup> Complexes Relevant as Radiopharmaceuticals. | We present a detailed density functional theory (DFT) investigation of the structural features and thermodynamic stabilities of La<sup>3+</sup> and Ac<sup>3+</sup> complexes relevant to develop radiopharmaceutical agents. A total of 16 chelators were considered, covering the acyclic and macrocyclic families functionali... |
41733369 | Whole-genome sequence analyses reveal cryptic species-level diversity among clinical <i>Actinotignum</i> isolates misidentified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. | <i>Actinotignum schaalii</i> is a human commensal bacterium that is well-known for causing urinary tract infections, predominantly in the elderly. However, reliable identification of <i>A. schaalii</i> in routine clinical microbiology has been challenging, mainly due to its fastidious growth and identification issues. ... |
41733183 | Data-Driven Engineering of Thermostable Collagen-Mimetic Peptoid Triple Helices. | Collagen-mimetic peptides (CMPs) are engineered molecules designed to replicate the triple-helical structure of natural collagen. A repeating x-y-Gly sequence is the defining motif of CMPs and is critical to their triple-helical structure and stability. Substitutions to the residues occupying the x and y positions pres... |
41733099 | Engineering Smart Bimetallic Ionic-Site MOF Nanozyme Nanocomposites for Microenvironment-Responsive Dynamic Therapy of Periapical Periodontitis. | Periapical periodontitis (AP) is an inflammatory disease caused by persistent endodontic biofilms, and its treatment remains challenging because conventional root canal therapy sometimes fails to achieve effective disinfection and tissue regeneration. Herein, a multifunctional bimetallic ion-modified metal-organic fram... |
41733090 | Interface-Enriched Fluorinated Covalent Organic Framework Enables Stable, High-Performance n-i-p Perovskite Solar Cells. | Buried interfacial integrity remains a major bottleneck limiting both the efficiency and long-term stability of perovskite solar cells (PSCs). Existing surface-modification strategies often introduce additional interfacial discontinuities, thereby exacerbating rather than alleviating buried-interface vulnerabilities. H... |
41733083 | Antimicrobial Peptides in Preventive Medicine: Current Perspectives on Coating Strategies. | The alarming rise of antimicrobial resistance and the declining efficacy of conventional antibiotics emphasize the need for preventive strategies. Within the setting of device-associated infections, antimicrobial peptides (AMPs) have been extensively studied as antimicrobial candidates, owing to their broad-spectrum ac... |
41732989 | Intra-articular Methotrexate-Loaded Microsponge as an Adjuvant Strategy for Rheumatoid Arthritis: Localized Treatment with a Systemic Impact. | Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic synovial inflammation and progressive joint destruction. Methotrexate (MTX) remains the gold standard in RA therapy, yet systemic administration often provides suboptimal joint targeting and causes dose-limiting toxicity. This study... |
41732963 | Defective Single-Site Nanozymes with Exposed Unsaturated Cu-N<sub>2</sub> Sites for Antitumor Immunotherapy via Innate Immune-Checkpoint Blockade. | Disrupting the redox balance of tumor cells while blocking MER proto-oncogene tyrosine kinase (MerTK)-mediated macrophage efferocytosis can simultaneously awaken and enhance innate and adaptive antitumor immunity. Herein, we develop an MRX-2843 (MerTK inhibitor) and Mn<sup>2+</sup> codelivered defective metal-organic f... |
41732094 | Modulating human IAPP aggregation in type 2 diabetes: inhibitors, mechanisms, and translational challenges. | Islet amyloid polypeptide (IAPP) aggregation is a characteristic pathological feature of type 2 diabetes (T2D), driving pancreatic β-cell dysfunction and loss through the formation of toxic oligomeric and fibrillar species. In recent years, significant advances in structural biology and chemical biology have deepened o... |
41731595 | Characterization of soy albumin based water-in-water emulsion and its application for entrapment of quercetin from onion peel waste. | This study characterizes water-in-water (W/W) emulsions, consisting of two immiscible water phases formulated using soy albumin with locust bean gum, guar gum, or xanthan gum as sustainable alternatives to traditional emulsions reliant on synthetic stabilizers. The emulsions were tested at varying protein-polysaccharid... |
41729722 | Advances and Sustainable Implementation of Nanomaterials in Water Remediation: A Comprehensive Review. | To overcome global water scarcity and pollution, nanomaterials have emerged as revolutionary tools for water remediation owing to their unique physicochemical properties, in particular, their ultrahigh specific surface area and programmable interface for molecular recognition. This review integrates multifaceted perspe... |
41665045 | Inter-ligand cross-links determine secondary building unit formation in oligoMOFs. | OligoMOFs are a class of metal-organic frameworks (MOFs) that feature ligands covalently cross-linked into oligomers as intrinsic structural components. A recent study has demonstrated that the size and flexibility of the tether moieties can result in the formation of oligoMOFs with different isomeric structures <i>via... |
41664631 | Tailoring porphyrinic MOF-545 performances for CO<sub>2</sub> photocatalytic reduction through linker chlorination. | The development of technologies for CO<sub>2</sub> sequestration and its conversion into value-added chemicals has received considerable and growing attention. However, achieving high conversion efficiency and product selectivity under mild conditions remains a major challenge. This study investigates the photocatalyti... |
41636249 | An iron-based organic framework-modified Cu-Co-Fe ternary layered double hydroxide enhanced adsorptive removal of antibiotics. | Adsorption has emerged as a green and promising solution for antibiotic removal in wastewater treatment systems, driving an urgent demand for designing high-performance and eco-friendly adsorbents that enable rapid and efficient elimination of antibiotic contaminants. Herein, a high-activity Fe-based metal-organic fram... |
41636114 | Hydroxyquinoline-functionalised aza-crown macrocycles for lanthanide coordination. | Emerging therapeutic radiolanthanides have utility for systemic molecular radiotherapy in nuclear medicine, provided that suitable chemical technology is available to incorporate them into receptor-targeted radiopharmaceuticals. In this work, <i>N</i>,<i>N</i>'-bis(8-hydroxyquinoline-2-ylmethyl)-4,13-diaza-18-crown-6 (... |
41610520 | Advances in design and application of molecularly imprinted polymers for selective brain protein recognition in neurology. | Neurological diseases affect billions of people worldwide, including an array of infections, strokes, cancers, and neurodegenerative disorders like Alzheimer's and Parkinson's, which have seen rising mortality rates in recent decades. The blood-brain barrier (BBB) is a critical protective layer composed of tightly seal... |
41582779 | Machine learning and AI empowering metal-organic frameworks: synthesis, performance prediction and therapeutic application. | Machine learning (ML), a subset of artificial intelligence (AI), has emerged as a powerful tool to address the bottlenecks in metal-organic framework (MOF) research. With the exponential growth of structural libraries rendering traditional trial-and-error experimentation intractable, data-driven models enable efficient... |
42007065 | Probing Biointerfaces with QCM‑D and Electrochemistry: Opportunities and Challenges toward Integrated EQCM‑D Biosensing. | Biosensing has garnered significant attention due to the demand for early disease diagnosis and the interest in biological interfaces where gravimetric response, hydration, mechanical deformation, and charge transfer are intrinsically coupled and dynamically evolving. Quartz crystal microbalance with dissipation monito... |
41994503 | Magnetic properties of molecules on surfaces studied with scanning probe methods. | Magnetic molecules on surfaces provide atomically precise test beds for quantum magnetism and device concepts in spintronics and quantum information. Scanning probe techniques now resolve and control single-molecule spin states, their coupling to substrates and emergent many-body phenomena, including the Kondo effect a... |
41908668 | Adamantane-based inhibitors of the influenza A M2 proton channel: structure-based design, biological evaluation, and synthetic approaches. | The influenza A matrix 2 (AM2) protein, a prototype of viroporins, conducts protons along a chain of water molecules and ionizable side chains, including histidine-37. Solid-state NMR (ssNMR) and high-resolution X-ray crystal structures have been obtained for AM2 wild-type (WT) constructs in complex with adamantanamine... |
41889750 | Left-Handed Helices in DNA Nanotechnology. | DNA nanotechnology involves the use of DNA as a material to build nanoscale shapes and structures. This strategy typically uses the conventional right-handed B-form DNA for nanoscale construction. In some cases, alternate nucleic acid structures, such as those that form left-handed helices, are used in the design and a... |
41889731 | Host-Guest Assembly of Transmucosal Molecular Spherical Nucleic Acids for Oral Leukoplakia Immunotherapy and Microbiota Homeostasis Restoration. | Oral leukoplakia (OLK) is a prevalent oral mucosal disorder and is at risk of malignant transformation. While nanomedicines hold great promise for OLK therapy, their current nanoformulations for topical treatment of OLK typically suffer from poor transmucosal penetration, neglect immunomodulation for suppressing epithe... |
41853682 | Computational evaluation of <i>Withania somnifera</i> phytocompounds targeting SARS-CoV-2 ORF9b Protein: Insights from molecular docking, ADMET and MD simulations. | The COVID-19 pandemic, caused by SARS-CoV-2, has emerged as a global health crisis, leading to widespread morbidity and mortality, causing significant disruption to daily life and socio-economic activities worldwide. The outbreak created an urgent need for novel therapeutics and vaccines. However, several of these phar... |
41852721 | pH-responsive CaCO<sub>3</sub> nanoplatform amplifies SDT via calcium overload-ROS loop for deep tumor therapy. | Sonodynamic therapy (SDT) for deep-seated tumors is limited by tumor microenvironment (TME) barriers. We developed a hyaluronic acid (HA)-modified mesoporous calcium carbonate nanoplatform (HA/CaCO<sub>3</sub>@Ce6) to synergistically enhance calcium overload and SDT. The CD44-targeted nanoplatform demonstrated pH-respo... |
41847610 | Selenium-catalyzed organic transformations. | Selenium-catalyzed organic transformations have recently emerged as a promising frontier in modern organic synthesis. The unique combination of high polarizability, redox tunability, and σ-hole-driven Lewis acidity enables selenium to act as powerful non-covalent activators in both covalent and non-covalent catalytic c... |
41835597 | An MOF-Graphene Interface for Efficient Electrochemical Sensing of Water-Soluble Organic Dyes. | Differential detection and quantification of organic dyes in aqueous media are demonstrated utilizing an electrochemical method on a nanocomposite of UiO-66-NH<sub>2</sub> MOF deposited on graphene nanoplatelets (MOF@G). The selected organic dyes are anionic molecules with overlapping UV-vis absorption bands, which mak... |
41835568 | Hybrid Bentonite-Zeolitic Imidazolate Framework Additive as an H<sub>2</sub>S Scavenger and Strength Enhancer for Class G Oil-Well Cement. | Optimization of cement slurry composition during well cementing jobs is highly critical to preserve well integrity under sour gas environments. This research focuses on the application potential of a hybrid bentonite-zeolitic imidazolate framework-67 (abbreviated as Bent/ZIF-67) as a hydrogen sulfide (H<sub>2</sub>S) s... |
41835512 | A Review of the Design and Synthesis of (Electro)chemically Induced Three-dimensional Nanoporous Copper: A Strategic Element for CO<sub>2</sub> Electro-Reduction and Self-Sanitization Applications. | The catalytic and self-sanitizing properties of copper (Cu) can be significantly enhanced by inducing nanoporosity into the structure. In this review, we first briefly introduce electrocatalysis and biocidal applications of Cu, with the discussion on electrocatalysis geared toward the electrochemical reduction of carbo... |
41835511 | Enhanced Charge Separation and Visible-Light Utilization in La-Doped MIL-100(Fe) for Efficient Cr(VI) Photoreduction. | Lanthanum-doped MIL-100-(Fe) (MIL-100-(Fe<sub>0.99</sub>/La<sub>0.01</sub>)) was successfully synthesized through a facile and environmentally friendly room-temperature stirring method to enhance charge separation and visible-light utilization for Cr-(VI) photoreduction. Structural characterization using XRD, FT-IR, SE... |
41809997 | Hemophagocytic lymphohistiocytosis induced by immune checkpoint inhibitors: observations and proposed clinical management. | Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory disease caused by an overactivation of immune cells. Its low incidence and broad range of clinical signs and symptoms may mimic more common inflammatory and/or infectious processes, causing delays in accurate diagnosis and management with a resultant ... |
41809914 | Castor oil and europium-based luminescent films for thermal sensing. | Luminescent thermometry has emerged as a powerful tool for remote temperature sensing, yet the development of sustainable materials that combine robust photophysical performance with environmental compatibility remains a challenge. Herein, we report a bio-derived luminescent thermometric film obtained by incorporating ... |
41809600 | Keratinases: microbial sources, mechanisms, and industrial applications in waste valorization. | Keratinous waste, a major by-product of agriculture and animal husbandry, is produced in massive quantities and is notoriously recalcitrant to degradation. With the expansion of the poultry and livestock industries, keratinous waste accumulation (e.g., feathers, hooves, and horns) has become a pressing environmental co... |
41809201 | Development of lysine-branched dendrimeric antimicrobial peptides targeting ESKAPE pathogens: broad-spectrum activity, biofilm eradication, and endotoxin neutralization. | Antimicrobial resistance (AMR) represents a pressing global health challenge, driving the urgent need for novel therapeutic agents with improved stability and selectivity. In this study, we present the rational design and synthesis of lysine-branched dendrimeric antimicrobial peptides (AMPs) based on short arginine/try... |
41808840 | Artificial intelligence-enabled multi-omics biomarkers for immune checkpoint blockade: mechanisms, predictive modeling, and clinical translation. | Immune checkpoint inhibitors (ICIs) have transformed oncology, yet durable benefit remains confined to a minority of patients, revealing the limitations of single biomarkers such as PD-L1 expression, tumor mutational burden, and microsatellite instability. Multi-omics profiling, spanning genomics, transcriptomics, epig... |
41808820 | SLC31A1 knockdown mitigates post-MI heart failure via regulation of copper metabolism. | <h4>Introduction</h4>Cuproptosis due to copper overload is a contributor to the progression of cardiovascular diseases, especially heart failure (HF) after acute myocardial infarction (AMI). Solute carrier family 31 member 1 (SLC31A1) is a major Cu2+ transporter responsible for intracellular Cu2+ uptake. In this study,... |
41808771 | Nanotech meets antibiotics: nucleotide antibiotics delivered by lipid nanoparticles. | The global spread of multidrug-resistant bacteria poses a serious challenge to effective therapy and public health. The rising resistance to small-molecule antibiotics underscores the limitations of conventional antimicrobial strategies and highlights the urgent need for alternative therapeutic modalities. Lipid nanopa... |
41808764 | Photocrosslinked dual-network hydrogel for sutureless corneal stromal lenticule lmplantation. | Corneal stromal lenticules obtained through small incision lenticule extraction (SMILE) procedures offer a valuable graft material for therapeutic applications. Current clinical utilization faces challenges due to intrinsic thinness (<140 μm) and restricted dimensions (generally around 6.6 mm). This study introduced a ... |
41800462 | Hypoxia-responsive self-assembled nanoparticles for reprogramming tumor-associated macrophages into an anti-tumor M1 phenotype in breast cancer. | The tumor microenvironment is characterized by hypoxia, resulting mainly from aberrant vascularization and insufficient blood perfusion. Under such hypoxic conditions, tumor-associated macrophages (TAMs) preferentially polarize toward an immunosuppressive M2-like phenotype, which promotes immune evasion and accelerates... |
41800459 | Advances in artificial metabzymes for macrophage polarization in tumor metabolic immunotherapy. | Malignant tumor progression is driven by profound metabolic reprogramming, which not only fuels tumor growth but also impairs antitumor immune functions, particularly by inhibiting M1-type tumor-associated macrophages (TAMs) and thereby reinforcing an immunosuppressive microenvironment. Recent advances in nanotechnolog... |
41800455 | Micro-nano integrated platforms for osteoarthritis therapy: From spatial manipulation to cellular reprogramming. | Clinical intervention for osteoarthritis (OA) has long been hampered by complex intra-articular physiological barriers, including rapid synovial clearance, the dense penetration resistance of the cartilage extracellular matrix (ECM), and a progressively deteriorating pro-inflammatory microenvironment. Conventional sing... |
41791328 | Photo-controlled biodegradable Zn alloy bone implant. | Zinc (Zn)-based biodegradable implants hold great promise for orthopedic applications, yet their clinical translation is hampered by uncontrollable corrosion leading to Zn<sup>2+</sup> release at potentially toxic levels in the early stage and insufficient osteogenic stimulation later. Herein, a near-infrared (NIR)-res... |
41785699 | Uptake kinetics and photocrosslinking of poly(ethylene glycol) diacrylate in the nanostructure of a self-assembled sulfonated pentablock polymer. | Self-assembly of charged ABCBA pentablock polymers that behave as thermoplastic elastomers with an anionic C block and spontaneously form highly ordered nanostructures makes them perfectly suited for a broad range of specialized applications. One strategy to exploit the inherent polymer morphology and simultaneously im... |
41783269 | Digital materials ecosystem: from databases to AI agents for autonomous discovery. | The concept of a digital materials ecosystem represents a new paradigm in materials research, where data, theory, and automation are integrated into a unified and iterative framework. By combining reliable databases, physical frameworks, and intelligent data analysis, materials discovery is evolving from empirical expl... |
41782990 | Hyaluronic acid engineered melanin-MOF nanoreactor synergistically remodeling redox and immune homeostasis for targeted acute lung injury therapy. | Reactive oxygen species (ROS)-triggered oxidative stress, inflammatory responses, and overactivation of immune cells are critical factors exacerbating acute lung injury (ALI). Conventional clinical therapies are often limited by non-specificity, single-target limitations, and significant side effects to precisely modul... |
41780430 | Defect-engineered metal organic framework thin film nanocomposite membranes for enhanced forward osmosis performance and microplastic antifouling. | The integration of metal-organic frameworks (MOFs) into forward osmosis (FO) membranes has emerged as an effective approach to improve water permeability while mitigating persistent challenges such as high reverse salt flux (RSF) and fouling. In this study, a novel defect-engineered UiO-66-NH<sub>2</sub> was synthesise... |
41777706 | The critical role of isolated Ti<sup>3+</sup> sites in MIL-125 for photocatalytic nitrate reduction: performance enhancement and deactivation mechanism. | Photocatalytic reduction of nitrate (NO<sub>3</sub> <sup>-</sup>) to ammonia (NH<sub>3</sub>) represents a sustainable route for wastewater treatment and chemical production. Metal-organic frameworks (MOFs) such as MIL-125 are promising catalysts, yet their performance often decays during reaction. This study reveals t... |
41777455 | Computational identification of rare pathogenic genomic variants in esophageal cancer markers: Transcript-level analysis, sequence-based insights, and structural-functional impacts of non-synonymous SNPs. | <h4>Background and aims</h4>Esophageal cancer (EC) is a rapidly progressing malignancy that significantly contributes to cancer-related mortality. The genetic causes of EC, particularly rare coding pathogenic variants, remain incompletely defined. This study focuses on non-synonymous single nucleotide polymorphisms (ns... |
41769265 | Drug Polymer Nanoparticles: An Advancement in Biomedical Solutions and Targeted Drug Delivery. | Polymer nanoparticles (PNPs) are compact particulate systems typically ranging from 10 to 1000 nm in size and have emerged as versatile platforms in modern biomedical research. Their growing importance stems from a unique combination of physicochemical properties, including tunable size, surface functionality, high dru... |
41767966 | A novel palladium-2-picolylamine complex grafted on magnetic UiO-66-NH<sub>2</sub> nanocomposites: as an efficient heterogeneous catalyst for fast Suzuki-Miyaura cross coupling. | This study reports the facile hydrothermal synthesis of a novel Fe<sub>3</sub>O<sub>4</sub>@UiO-66-NH<sub>2</sub> magnetic metal-organic framework (MOF) nanocomposite, bypassing the need for additional surface functionalization of Fe<sub>3</sub>O<sub>4</sub>. This amine-functionalized magnetic MOF serves as an efficien... |
41767814 | Visible-light-driven valorization of 5-hydroxymethylfurfural over a hollow Co<sub>3</sub>O<sub>4</sub>@Zn<sub>3</sub>In<sub>2</sub>S<sub>6</sub> nanocage in base-free water under an air atmosphere. | Visible-light-driven upgrading of biomass-derived 5-hydroxymethylfurfural (5-HMF) represents a green and sustainable strategy. However, photocatalytic selective oxidation of HMF to generate 2,5-diformylfuran (DFF), a highly promising biomass-derived molecule for pharmaceuticals and heterocyclic ligands, is extremely ch... |
41752198 | Characterization of Conformational Instability of Monoclonal Antibodies During Chromatographic Purification. | Monoclonal antibodies represent one of the fastest-growing sectors of the biopharmaceutical industry. Their high therapeutic efficacy and reduced incidence of adverse effects compared to conventional therapies have led to an increasing demand for these products. The costliest stages of monoclonal antibody production ar... |
41747579 | Optimizing charge transfer pathways in nickel metal-organic framework for enhanced CO<sub>2</sub> photoreduction. | Nickel Metal-Organic Frameworks (MOFs) Ni-BDC (BDC: 1,4-benzenedicarboxylic acid) with coordination-unsaturated metal sites (CUMs) exhibits remarkable CO<sub>2</sub> reduction activity under visible-light irradiation. However, its photocatalytic mechanism remains a challenging due to complex charge-transfer pathways. H... |
41740937 | Effect of microbial source cultivation methods on sulfate-containing wastewater treatment performance in microbial electrolytic cells. | Microbial electrolysis cells (MECs) have advantages in treating sulfate-containing wastewater, but challenges such as prolonged reactor start-up cycles have limited their development. By comparing the effects of different microbial sources on MEC performance, we found that inoculating the biocathode with enriched bacte... |
41740909 | In situ delipidation-based structure of low-density lipoprotein and apolipoprotein B-100 physiologically imaged by atomic force microscopy. | Apolipoprotein B-100 (apoB-100) is the main structural protein of apoB-containing lipoproteins including low-density lipoprotein (LDL). Its organization or lipidation process in an apoB-containing lipoprotein particle is still unclear. To understand its organization in a LDL particle, the combination of atomic force mi... |
41740907 | Synthesis of construction of Astragalus polysaccharide-curcumin nanoaggregates based on the concept of "unification of medicines and excipients" and their study on anti-ulcerative colitis effects. | This study employs the concept of "unification of medicines and excipients " to prepare nanoaggregates by loading Curcumin (CUR) onto Astragalus polysaccharide (APS) as the drug carrier. This strategy seeks to improve CUR's bioavailability and water solubility, therefore enhance its therapeutic efficacy for the treatme... |
41740657 | A novel CNC-ZIF-8 nanocomposite exhibits potent antibiofilm activity against cariogenic Streptococcus mutans. | Oral biofilms are key contributors to the development of dental caries and various periodontal diseases. Streptococcus mutans is a primary bacterium responsible for causing dental caries. Dental implants are frequently used to replace missing teeth, but biofilm accumulation on these implants is a major factor in implan... |
41746002 | The Role of Five Key Minerals (Cu, Se, Zn, Co, Fe) in Reproductive Function of Female Cattle: Current Insights and Future Directions. | Reproductive efficiency in female cattle is significantly influenced by micronutrient status, particularly the availability and balance of essential trace minerals. Selenium, copper, zinc, cobalt, and iron serve as critical components of enzymatic systems, antioxidant defense networks, hormone synthesis, and cellular m... |
41746003 | Dietary Fiber Regulation of Gut Microbiota and Bile Acid Metabolism in Animals: Implications for Animal Nutrition. | Dietary fiber (DF) is a fundamental component of animal nutrition and has been widely studied for its nutritional and physiological functions in animals. While existing studies mainly focus on the independent effects of DF on gut microbiota or bile acids (BAs), the mechanisms underlying their interactions remain poorly... |
41745568 | Construction of an In Vitro Blood-Brain Barrier Micro-Organoid Model Using Decellularized Squid Mantle Scaffold Film. | Although blood-brain barrier (BBB) models are of great value in investigating neurological diseases, the structural complexity and intricate function based on cell-cell interactions of the BBB bring various limitations to the applications of existing models. In this study, a novel BBB micro-organoid model was establish... |
41744903 | Microsecond Dynamics of Fc-CD16a Recognition: Impact of Mutations, Core Fucosylation, and Fc Asymmetry. | <h4>Background/objectives</h4>Antibody-dependent cellular cytotoxicity relies on the interaction between the Fc region of immunoglobulin G1 (IgG1) and the CD16a receptor. While removal of core fucosylation on Fc and introduction of the DFTE mutation set (S239D, H268F, S324T, I332E) are known to enhance CD16a binding, t... |
41743456 | Biobased adhesive hydrogels for wound management and tissue repair: From materials to advanced applications. | Effective tissue adhesion under wet and dynamic physiological conditions remains a major challenge in wound management and tissue repair. Conventional tissue adhesives often suffer from limited biocompatibility, inadequate wet adhesion, or lack of degradability, restricting their broader clinical use. In recent years, ... |
41737787 | Empowering molecular complexity <i>via</i> biocatalysis: emerging blueprints in the total synthesis of medicinally relevant natural products. | Biocatalysis has ascended as a defining force in contemporary total synthesis, furnishing catalytic modalities that deliver molecular complexity with unparalleled chemo-, regio-, and stereo-control. As structurally sophisticated therapeutics-including macrocyclic lactones, polyketides, terpenoids, alkaloids, and pharma... |
41737492 | Formulation approaches for colon-specific drug delivery: conventional to nanocarrier systems. | The development of colon-targeted drug delivery systems (CDDS) has gained increasing attention due to their potential to improve therapeutic outcomes for diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colorectal cancer, and other colonic disorders. Targeted delivery to the colon offe... |
41737449 | Carbon quantum dots as transcutaneous drug carriers: mechanisms, challenges and prospects. | Incorporation of nanoparticles has revolutionized drug delivery by optimizing the targeted transport of drugs, boosting the solubility and stability of pharmaceuticals, and facilitating precise, controlled release. These breakthroughs have made a significant contribution, especially in personalized medicine for many he... |
41737453 | Isolation and characterization of antiplasmodial and antimicrobial compounds from <i>Tetracera alnifolia</i> using a bioassay-guided approach. | A preliminary biological screening demonstrated that leaf extracts from <i>Tetracera alnifolia</i> exhibit promising activity against <i>Plasmodium falciparum</i> and <i>Candida albicans</i>. To identify the constituents responsible for these effects, a bioassay-guided fractionation strategy was subsequently employed. ... |
41734836 | Construction of a permeation-promoting repair emulsion based on gum arabic/β-cyclodextrin microencapsulation stabilized peony seed oil and investigation of its mechanism for photodamage repair. | Ultraviolet radiation is recognized as the primary cause of skin photodamage. Although peony seed oil, rich in bioactive components, exhibits significant photoprotective effects, its highly unsaturated nature renders it susceptible to oxidative degradation, thereby limiting its practical application. In this study, we ... |
41732032 | Potassium-Doped Borophane Nanosheets: A Multifunctional Platform for Reversible Hydrogen Storage and Metal-Free Hydrogen Transfer. | 2D borophene has long been proposed as a promising hydrogen storage material, but experimental demonstrations remain limited to boron hydride sheets derived from MgB<sub>2</sub>. Here, we report the synthesis of potassium-doped borophane (BH) nanosheets, which serve as a high-capacity, reversible hydrogen storage platf... |
41732013 | Mechanochemical Fullerene Nanoencapsulation in Amino-Functionalized ZIF-12 for Visible-Light Disinfection of Waterborne Viruses and Bacteria. | Water contamination poses a significant threat to public health and environmental sustainability, necessitating the development of efficient purification technologies. This study reports the mechanochemical synthesis of an amino-functionalized ZIF-12 framework with encapsulated fullerene (C<sub>60</sub>) as a bifunctio... |
41732001 | A Chiral 2D Sheet for Enhancing GLUT1 Function Through the Interplay of Architecture and Recognition. | Controlling cellular function from the extracellular space requires synthetic materials capable of specific and sustained interactions at the cell membrane. This typically demands a synergy between the material's overall architecture and its molecular-level recognition motifs. Here, we demonstrate this synergistic prin... |
41731921 | A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection. | Hyperactivation of monoamine oxidase enzymes (MAO) is associated with uncontrolled production of neurotoxic compounds such as reactive oxygen species, whose accumulation is linked to neurodegenerative, chronic, and age-related diseases. Although chromo-fluorogenic probes for detecting and quantifying MAO activity have ... |
41731650 | Targeting of the Gram-Negative Outer Membrane for Antibiotic Discovery and Potentiation. | The emergence of multidrug resistance underscores the urgent need to develop new classes of antibiotics with novel mechanisms of action. The majority of antibiotics currently in use are designed to target Gram-positive bacteria. However, Gram-negative bacteria can circumvent the effects of the majority of drug molecule... |
41731575 | Neutrophil-mediated delivery of curcumin-loaded manganese-doped zeolitic imidazolate framework-8 nanozymes for pulmonary arterial hypertension. | <h4>Background</h4>Pulmonary arterial hypertension (PAH) is a severe vascular disease characterized by oxidative stress, inflammation, vascular remodeling, and endothelial‑to‑mesenchymal transition (EndoMT), leading to high pulmonary arterial pressure and right heart failure. Current therapies offer only symptomatic re... |
41731565 | Resveratrol‒loaded self‒assembled tetrahedral framework nucleic acids reshape the epileptic microenvironment by regulating oxidative stress and neuroinflammation via the SIRT3/SOD2 pathway. | <h4>Background</h4>Epilepsy management remains a significant clinical challenge, as conventional antiseizure medications primarily mitigate symptoms without addressing the core pathological drivers, specifically the vicious cycle formed by neuroinflammation and oxidative stress. Furthermore, the therapeutic efficacy of... |
41731511 | Macrophage-delivered Nifuroxazide reprograms immunosuppressive microenvironment and synergizes with oxaliplatin for enhanced anti-hepatocellular carcinoma therapy. | Nifuroxazide (NFX), an antibacterial agent, also exhibits notable antitumor effects by inhibiting STAT3 signaling, which is often aberrantly activated and linked to chemoresistance in tumors such as hepatocellular carcinoma (HCC). Combining NFX with chemotherapy may enhance therapeutic efficacy, but its poor solubility... |
41731500 | Targeting redox metabolism and low-dose radiotherapy synergistically activate cGAS-STING pathway to improve NK cell therapy efficacy in hepatocellular carcinoma. | Adoptive natural killer (NK) cell therapy (ANKCT) is a promising strategy for hepatocellular carcinoma (HCC); however, its efficacy is hampered by insufficient NK cell homing and the immunosuppressive activity of M2-polarized tumor-associated macrophages (TAMs). Activation of the cyclic guanosine monophosphate (GMP)-ad... |
41731116 | Arthropod exosomal glycine-rich protein as a potential vaccine candidate effectively reduces tick blood-feeding and pathogen transmission. | During blood feeding, Ixodidae ticks secrete cement proteins, including glycine-rich proteins (GRPs), that facilitate attachment to the vertebrate host. However, the molecular mechanisms underlying exosomal GRP secretion at the feeding site and their roles in tick-pathogen interactions remain poorly understood. Here, w... |
41731077 | Epigenetic dysregulation of IRF9 drives excessive interferon signaling in COPD. | Altered respiratory barrier integrity and impaired lung regeneration are hallmarks of chronic obstructive pulmonary disease (COPD). To investigate the molecular mechanisms driving the impaired regeneration of alveolar epithelial progenitors in COPD, we generated whole-genome DNA methylation and transcriptome maps of so... |
41730904 | Telomeric repeat-containing RNA G-quadruplexes trigger ZBP1-mediated cell death. | Z-DNA-binding protein 1 (ZBP1) is a nucleic acid sensor with two Z-DNA-binding domains (Zα domains) that bind Z-DNA and Z-RNA, mediating inflammatory cell death in development and disease. A recent study has demonstrated that the truncated isoform ZBP1-S senses telomeric repeat-containing RNA (TERRA), activating innate... |
41730911 | Complete defluorination of PFASs via photocatalytic reduction in water. | The environmental persistence of per- and polyfluoroalkyl substances (PFASs), driven by the exceptional stability of their C-F bonds, presents a formidable challenge for remediation. Herein, we report the 5,10,15,20-tetraphenyl (4-aminophenyl) porphyrin (TAPP) aggregates as visible-light-driven photocatalysts capable o... |
41730895 | Solid-liquid interface synthesis of selective (111)-oriented Cs<sub>2</sub>AgBiBr<sub>6</sub> perovskite crystals. | Achieving the preferred orientation of specific facets is crucial for regulating the anisotropic physical properties of crystal materials and optimizing the performance of semiconductor optoelectronic devices. However, the intrinsic challenges lie in precisely controlling the growth kinetics of crystal facets and suppr... |
41730884 | From the same supramolecular framework to distinct types of porous liquids via in-situ transformation. | Porous liquids (PLs), integrating porous hosts into flowing liquids through intermolecular interactions, attract significant attention, while their controlled synthesis remains challenging. Here we report a controllable in-situ transformation strategy to fabricate distinct types of PLs from the same supramolecular fram... |
41730889 | Crystallization-assisted water adsorption in amorphous molecular adsorbents. | Efficient and stable water adsorbents are essential for removing moisture from natural gas and olefins during their production. Industrial desiccants such as alumina and zeolites require high regeneration temperatures, while metal-organic frameworks often suffer from limited long-term stability and reusability. Here, w... |
41730872 | Transforming disorder in the design of advanced high-entropy oxide electrocatalysts for zinc-air batteries. | Research on high-entropy oxides generally is limited to elemental and structural interpretations applied to the performance of cathodes. However, there are only limited data on the principles of increasing disorder in terms of structural, electronic, and atomic mechanisms as materials convert from ordered to disordered... |
41730860 | Organocatalyzed bottom-up formation of protocells. | The organisation of living systems into cellular structures is a characteristic that enables differentiation from the environment. A pivotal step in the development of life is compartmentalisation, achieved through the formation of vesicle-like structures. Fatty acids - or phospholipids - have been used to simulate pre... |
41730854 | Feedback neurons based on perovskite memristor with nickel single-atom engineered reduced graphene oxide cathode. | The demand for bio-inspired neuromorphic systems drives research on artificial neuronal devices with dual excitatory/inhibitory capabilities. Although perovskite memristors show promise, interfacial barriers and rapid ion migration hinder modulation. This study addresses these challenges through atomic-scale cathode en... |
41730273 | Rutin Stabilises β-Catenin Through GSK3β Inhibition to Promote Hair Follicle Regeneration. | Rutin directly binds to GSK3β, stabilising β-catenin and activating Wnt/β-catenin signalling to drive hair cycle. |
41729996 | Src-dependent tyrosine-phosphorylation of NM2A has a protective role against bacterial pore-forming toxins. | Pore-forming toxins (PFTs) are key bacterial virulence factors that disrupt host plasma membrane (PM) integrity, triggering cellular stress and initiating repair mechanisms. The cytolysin Listeriolysin O (LLO), secreted by Listeria monocytogenes, has well established roles in infection, yet the host signaling responses... |
41729981 | Development of DHODH inhibitors incorporating virtual screening, pharmacophore modeling, fragment-based optimization methods, ADMET, molecular docking, molecular dynamics, PCA analysis, and free energy landscape. | The overexpression of dihydroorotate dehydrogenase (DHODH) in various malignant tumor cells is significantly associated with ferroptosis, making DHODH inhibition a promising strategy for cancer therapy. In this study, we employed an integrated approach to screen and optimize DHODH inhibitor candidates. First, virtual s... |
41729907 | Flexible Organic Clip as an Adapter to Enhance Host-Guest Nanopore Single-Molecule Sensing. | The host-guest nanopore analysis method provided an avenue for hydrophobic analytes detection. However, the fixed cavity of conventional rigid hosts restricted the size range of detectable analytes, thereby partly limiting their further development. Herein, an organic clip (OC) was used as a flexible host to enhance th... |
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