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41729617 | BN-Polarized Azaboracyclophanes as Tunable Electrostatic Molecular Cavities for Host-Guest Binding and Capture. | Azaboracyclophanes constitute a new class of three-dimensional, charge-separated molecular cavities in which B-N dative bonds function as internal polarizing elements, generating oriented electrostatic environments akin to confined electric fields. Using density-functional theory, we show that systematic incorporation ... |
41729568 | Protein-induced membrane strain drives supercomplex formation. | Mitochondrial membranes harbor the electron transport chain (ETC) that powers oxidative phosphorylation (OXPHOS) and drives the synthesis of ATP. Yet, under physiological conditions, the OXPHOS proteins operate as higher-order supercomplex (SC) assemblies, although their functional role remains poorly understood and mu... |
41729570 | Structural Modulation of Porphyrin-Based Supramolecular Prisms for Efficient and Selective Photocatalysis. | Porphyrin and its derivatives have been widely used as photocatalytic units owing to their strong absorption in the visible region. However, their extended π-conjugated systems will lead to aggregation and reduce the photocatalytic efficiency. In this work, we report the construction of supramolecular prisms <b>S1</b> ... |
41729402 | Divergence and conservation of satellite DNA in the loggerhead sea turtle (Caretta caretta): a comparative cytogenomic analysis. | Repetitive DNA sequences, particularly satellite DNA (satDNA), are key components of eukaryotic genomes with important structural and potential functional roles. In this study, we used long-read assemblies and short-read sequencing to perform de novo identification of the most abundant satDNAs in the sea turtle Caretta... |
41729346 | In silico conversion of ssRNA aptamers to ssDNA: molecular dynamics assessment of structural stability and conformational preservation. | The application of single-stranded RNA (ssRNA) aptamers may be limited by their chemical instability and susceptibility to enzymatic degradation, despite their high structural specificity. Thus, this study presents a computational workflow for the rational conversion of ssRNA aptamers (A6 and A11), previously selected ... |
41729079 | SARS-CoV-2 antibody-dependent enhancement of infection depends on antibody binding to both ACE2 and Fc receptors. | Antibody-dependent enhancement (ADE) of infection is a well-described phenomenon for several viruses, including dengue, Ebola, respiratory syncytial virus, and HIV. ADE occurs when virus-antibody complexes engage Fc receptors (FcRs) and virus-specific receptors, enhancing infection under conditions of incomplete neutra... |
41729023 | Helix-Sense Selective Polymerization versus Polymerization-Induced Helix-Sense Selective Self-Assembly: From Controlled Synthesis to in Situ Chiral Self-Assembly. | ConspectusInspired by the precise helical architectures of biomacromolecules, researchers are increasingly focusing on the synthesis of helical polymers and supramolecular assemblies. Helix-sense selective polymerization has emerged as a reliable method for preparing optically active helical polymers, where a preferred... |
41728966 | Principles for Optimal Electrode Design and Operation for Desalination with Electrochemical Ion Pumping. | Electrochemical ion pumping (EIP) is an emerging electrochemical separation form that eliminates solution mixing in conventional capacitive deionization and enables pseudocontinuous desalination with unidirectional ion flux. In this work, we systematically investigate electrode design and operational parameters governi... |
41728971 | Functional characterization of a novel class A carbapenemase CAE-1 in carbapenem-resistant <i>Pseudomonas aeruginosa</i> clinical isolates. | Two carbapenem-resistant <i>Pseudomonas aeruginosa</i> (CRPA) isolates were collected, which lacked known carbapenemases but produced a β-lactamase CAE-1. CAE-1 was recently found in <i>Comamonas aquatica</i> and conferred resistance to penicillins and cephalosporins. In this study, we aim to know whether CAE-1 was res... |
41728937 | Lipidomics reveals the pro-viral roles of ceramides during fish nodavirus infection. | Red-spotted grouper nervous necrosis virus (RGNNV) is one of the most lethal viral pathogens with high mortality in the fry and juvenile stage of marine fish. Our previous studies demonstrated that RGNNV infection induced the remodeling of intracellular membrane and exploited cellular fatty acid synthesis for infection... |
41728671 | Hydrophilic Janus Micelles From an ABC Triblock Copolymer. | We describe the creation of an amphiphilic triblock copolymer that drives lateral phase separation within micelle coronas. The design combines a hydrophobic poly(lactide) (PLA) core‑forming block with two distinct hydrophilic segments: poly(ethylene glycol) (PEG) and poly(N‑vinylpyrrolidone) (PVP). In water, the copoly... |
41728640 | A Chalcogen Bonding Catalysis Platform for Isoprenoid Cyclization: Broad Scope and Diverse Product Frameworks. | Cyclization of isoprenoids is one of the most important biosynthetic events that yields the largest class of natural products. Yet, a noncovalent catalysis strategy for isoprenoid cyclization remains elusive. Furthermore, a general synthetic method using artificial catalyst that enables isoprenoid cyclization with dive... |
41728647 | Calix[4]arene Design for Enhanced Carbon Capture via Topological Learning. | Solid direct air capture (S-DAC) technologies have the potential to remove pre-existing CO<sub>2</sub> from the atmosphere by taking advantage of hydrophobic materials that will retain CO<sub>2</sub> through physisorption and separating it from the abundant water molecules. Calix[n]arenes are highly tunable and versati... |
41728643 | Aminal-linked Covalent Organic Frameworks for Light Energy Upconversion. | The conversion of two low-energy photons into a single higher-energy photon at low irradiance is highly desirable for bioimaging and solar energy harvesting. Yet translating established solution-phase triplet-triplet annihilation upconversion (TTA-UC) systems into robust solid-state platforms remains a challenge. Here,... |
41728632 | Asymmetric Induction With Chiral Carbon-Bonding Donors. | Carbon bonding has recently been introduced as a new tool in organic synthesis. Yet, it remains unclear whether this unique weak interaction can induce chirality or not. Herein, we report the synthesis of chiral carbon-bonding donors, and present the proof-of-concept study on asymmetric induction using this noncovalent... |
41725558 | Peptide-Functionalized Rosette Nanotubes: Programmable Supramolecular Assembly and Tunable Peptide Surface Organization. | Rosette nanotubes (RNTs) are supramolecular tubular nanostructures assembled from guanine-cytosine-inspired (G∧C) motifs. Building on earlier preliminary studies, we present a comprehensive nanoscale investigation and characterization of peptide-functionalized RNTs as modular scaffolds for programmable surface organiza... |
41725509 | Multifunctional Asymmetric Soluble Covalent Organic Frameworks: A Versatile Medium for Stabilizing Lithium Anode Interfaces. | To address the issues of uncontrollable lithium dendrite growth and an unstable solid electrolyte interphase (SEI) in lithium anodes, we designed an asymmetric and multifunctional COF material (CityU-55) composed of strongly solvating polyether and highly electronegative fluoroalkyl side groups. This material was emplo... |
41725432 | Dual Recognition and Highly Sensitive Detection of ATP by Aptamer-Bridged MOF Functionalized Glass Nanopipette. | Responsive nanopore-based sensors have evolved to be powerful analytical tools in biosensing territory. Although taking advantages including label-free, low-cost, and analytical universality, the detection sensitivity is hampered by recognition efficiency of the responsive element in the nanoconfinement. Here, we show ... |
41725014 | Activation of Nrf2 with natural flavonoids and mesenchymal stromal/stem cells: mechanisms and therapeutic potential for inflammatory diseases. | Redox balance is crucial for maintaining normal physiological functions. Its disruption by oxidative stress can trigger or exacerbate a series of pathological cascades, ultimately contributing to various chronic diseases, particularly inflammatory disorders. Inhibiting oxidative stress and its associated pathological c... |
41724929 | Multicomponent Ganoderma lucidum spore-based solid self-nanoemulsifying system of paclitaxel for improved lymphatic absorption and immune synergistic antitumor strategy. | In colorectal cancer, the cancer-immunity cycle is often disrupted by the lack of effective tumor-associated antigens, impaired activation of antigen-presenting cells, and insufficient T cell infiltration, leading to tumor immune escape and disease progression. Therefore, we developed PTX-GLSO SEDDS@GLS (PGS@GLS), a mu... |
41724841 | Bacterial defense mechanisms against bacteriophages: an evolutionary arms race. | Bacteria and bacteriophages are in a co-evolutionary arms race, developing intricate bacterial defense mechanisms that enable phage resistance and counterstrategies. Bacteria evolve diverse defense mechanisms to inhibit each stage of the phage infection cycle.Surface-based defenses prevent phage adsorption and infectio... |
41724832 | An in-silico study to design C<sub>60</sub> fullerene-based nanosensors for the adsorption, detection, and removal of the narcotic drug γ-hydroxybutyric acid. | γHydroxybutyric acid (GHB), a depressant of the central nervous system, is commonly used illegally and in drug-facilitated crimes; therefore, it is crucial to develop reliable and fast methods for detecting GHB. This study uses DFT theory to design and evaluate the performance of electrochemical and colorimetric nanose... |
41603893 | Metabolomic analysis reveals novel ethylated hydroxytyrosol metabolites in colon cancer cells. | Plants produce a diverse array of secondary metabolites, with hydroxytyrosol (HT) and its derivatives distinguished by their antioxidant and chemopreventive properties. Upon dietary consumption, native HT undergoes extensive biotransformation, initially facilitated by the gut microbiota. Increasing evidence suggests th... |
41532813 | Processable microporous membranes: emerging platforms for separation technologies. | Processability has emerged as a critical requirement for translating microporous materials into scalable membrane technologies, yet many porous frameworks remain difficult to fabricate as large-area, defect-free membranes. This review adopts a processability-centred perspective to examine recent advances in purely orga... |
41392718 | Machine learning to design metal-organic frameworks: progress and challenges from a data efficiency perspective. | This review critically examines work at the intersection of machine learning (ML) and metal-organic frameworks (MOFs). The modular nature of MOFs enables immense design flexibility and applicability to a wide range of applications. However, the combinatorially large design space also stresses the resource-intensive nat... |
41313218 | Structural polymorphism in bent-core liquid crystals: from helical nanofilaments to heliconical-layered microcylinders with light-responsive properties. | We report the self-assembly behavior and light-responsive polymorphism of azobenzene-containing bent-core liquid crystal dimers exhibiting B4 crystal phases. By systematically varying the terminal alkyl chain length, the supramolecular morphology transitions from helical nanofilaments (HNFs) with negative Gaussian curv... |
41858865 | Application and prospects of nanomaterials in osteoporosis treatment. | Osteoporosis is characterized by uncoupled bone remodeling, microarchitectural deterioration, and impaired fracture or defect healing, resulting in increased fragility and a high lifetime fracture burden. Current pharmacotherapies can reduce fracture risk, yet their impact is constrained by systemic exposure, adherence... |
41835613 | Molecular Insights into the Incorporation of Platinum-Based Drugs into Lipid Aggregates. | Platinum-based (Pt-based) compounds remain a cornerstone of chemotherapy, yet their clinical use is limited mainly due to poor tumor specificity and systemic toxicities. Fatty acid conjugation has emerged as a promising strategy to overcome the limitations of conventional platinum drugs by enhancing lipophilicity, impr... |
41835566 | Coordination Chemistry at the Hard-Soft Interface: Phosphine Oxide-Based Rare Earth/Transition Metal Complexes. | A series of monometallic Al-(III), Sm-(III), Dy-(III), Er-(III), and Yb-(III) complexes, featuring tetraphenyldiphosphine monoxide (PPO) as a ligand, were synthesized and characterized. These complexes served as precursors for the construction of heterobimetallic rare earth (RE)/transition metal (TM) assemblies. Attemp... |
41835502 | Fabrication of MOF-Functionalized Silica Monoliths and Their Unique Retention Behavior in HPLC. | We report the development and characterization of stationary phases based on metal-organic frameworks (MOFs) composed of metal ions and organic ligands for use in high-performance liquid chromatography (HPLC). In particular, we focus on a subnanoporous MOF, [Zn<sub>2</sub>(1,4-ndc)<sub>2</sub>(ted)] <sub><i>n</i></sub>... |
41809375 | Brain-targeting nanoplatform repurposing silymarin for enhanced GBM immunotherapy via synergistic mitochondrial suppression. | Glioblastoma (GBM), a highly malignant central nervous system tumor, poses a major therapeutic challenge due to the poor blood-brain barrier (BBB) permeability and an immunosuppressive tumor microenvironment. Notably, silymarin, a natural compound known for its anti-inflammatory and liver-protective properties, has eme... |
41798587 | Oscillatory dynamics in paclitaxel-proteinoid networks. | Paclitaxel is a widely used microtubule-targeting chemotherapeutic, yet its intrinsic electrochemical behavior remains poorly understood. Here we investigate the electrochemical and oscillatory properties of paclitaxel incorporated into proteinoid microspheres that mimic cellular environments. Using scanning electron m... |
41764853 | Phase separation in block copolymer systems: From thermodynamics to industrial applications. | Block copolymers exhibit unique phase separation and structural transitions, making them highly relevant in industrial applications. This review provides a critical analysis of block copolymer systems, focusing on the thermodynamics of micro- and macro-phase separation and their ability to self-assemble into diverse mo... |
41762800 | Development of a near-infrared fluorescence sensing platform based on TCPP-His@ZIF-8 for highly sensitive mitoxantrone detection. | A novel near-infrared luminescent fluorescent composite material, TCPP-His@ZIF-8, was successfully constructed. Through an amide condensation reaction, Tetrakis (4-carboxyphenyl) porphyrin (TCPP) was covalently anchored onto the surface of L-histidine (His) -modified ZIF-8 metal-organic framework. This material serves ... |
41754725 | Amino-Functionalized Poly(2-Ethyl-2-Oxazoline)-Ran-Poly[2-(3-Butenyl)-2-Oxazoline] Copolymers Used as Non-Viral Vectors for Nucleic Acid Delivery: Impact of Polymer Structure and Composition. | In this work, we designed non-viral gene delivery vector systems based on three poly(2-ethyl-2-oxazoline)-ran-poly[2-(3-butenyl)-2-oxazoline] copolymers functionalized by primary, secondary, and tertiary amino groups. The impact of copolymer structure and composition was sought through the examination of basic physicoc... |
41747548 | In situ-grown ambient-temperature dual-emissive RhB/COF@ZIF-90 composite for ratiometric fluorescence detection of tetracycline in foods. | In this work, a fluorescent sensor based on dual-emissive RhB/COF@ZIF-90 composite was fabricated for ratiometric detection of tetracycline (TC) residues in foods. To mitigate the aggregation-caused quenching (ACQ) effect of TAPB-DMTA COF, ZIF-90 on TAPB-DMTA COF composite was fabricated by an in situ growth strategy. ... |
41747550 | Insights into the copigmentation effect and mechanism of five carbohydrates on thermal and color stability of mulberry anthocyanins. | The copigmentation effects and underlying mechanisms of β-cyclodextrin (β-CD), chitosan (CS), guar gum (GG), xanthan gum (XG), and β-glucan (β-GC) on the stability of mulberry anthocyanins (MAS) were systematically investigated. β-CD exhibited the strongest protective effect, followed by CS and β-GC. At 60 °C, β-CD ext... |
41747455 | Fabrication of electrospun nanofibers of flurbiprofen-cyclodextrin inclusion complexes for anti-inflammatory assessment in skin fibroblast cell line. | In this study, electrospinning successfully produced nanofibers (NFs) of the anti-inflammatory drug flurbiprofen (FP) with 2-hydroxypropyl-β-cyclodextrin (HPβCD) and methyl-β-cyclodextrin (MβCD) in a 1:1 M ratio, exhibiting average fiber diameters of 399 ± 90 nm and 710 ± 105 nm, respectively. The formation of stable I... |
41747354 | HIFU-triggered burst release of gallic acid from gelatin/polyvinyl pyrrolidone hydrogel network crosslinked with magnesium gallate MOF. | In this study, we report the high-intensity focused ultrasound-triggered burst release of gallic acid from a gelatin-polyvinyl pyrrolidone (PVP) based hydrogel crosslinked with magnesium gallate (Mg-Gal) microparticles. Hydrogel was fabricated with 5% gelatin and 5% PVP as polymeric components crosslinked with 0.5% of ... |
41745056 | Gel-Inspired Trapping Networks: Fe(III)-Activated Palygorskite Nanorod Aggregates for Enhanced Congo Red Sequestration. | Developing adsorbents that combine high capacity with structural robustness remains a critical challenge for dye wastewater treatment. In this study, we propose a "pollutant-induced gelation" strategy to address this limitation, using Fe(III)-activated palygorskite nanorod aggregates as a model system for the highly ef... |
41744749 | Fungal Frontiers in (Bio)sensing. | Filamentous fungi are increasingly recognized as versatile biological platforms for the development of advanced (bio)sensing technologies, owing to their extensive secretory capacity, material-forming ability, and intrinsic bioelectrical activity. This review critically surveys recent progress in fungal-based sensing w... |
41737280 | Recognition, Signal Transduction, and Amplification of Nucleic Acids Under Isothermal Condition. | Isothermal nucleic acid detection has become a compelling alternative to PCR, enabling rapid analysis with minimal instrumentation and strong potential for point-of-care use. Central to assay performance are three interconnected processes: recognition, signal transduction, and amplification. Recognition strategies now ... |
41734878 | Ce-Fe bimetallic zeolite-imidazolate framework catalyzed ozonation for enhanced tetracycline degradation: synergistic electron transfer and multi-radical reaction pathways. | In this paper, the bimetallic zeolite imidazolate framework Ce-Fe-MI as a high-performance catalyst for ozonation-based degradation of tetracycline (TC) was investigated. During the catalytic process, electron transfer occurred between the two metal ions on the catalyst, and the mixed-valence state induced charge imbal... |
41725349 | A MOF-Lanthanide Theranostic Agent with Bidirectional Near-Infrared Photon Conversion for Tumor-Responsive Therapy and Real-Time Imaging. | Smart tumor-responsive theranostic agents are crucial for advancing precision medicine by enabling targeted drug delivery with minimal off-target effects and allowing real-time monitoring of therapeutic outcomes. Although metal-organic frameworks (MOFs) hold promises as nanocarriers, they often lack integrated, stimuli... |
41725260 | Bioinspired Interfacial Hitchhiking: 3D Hierarchical Nanopesticide Aggregates via Heterointerface-Confined Coassembly for Spatiotemporal Foliar Deposition and Translocation In Vivo. | Efficient foliar delivery of agrochemicals requires precise spatiotemporal control over both foliar deposition and translocation in vivo. Drawing inspiration from natural systems, such as biomolecular recognition and vesicular transport across cellular membranes, the work proposes a heterointerface-confined coassembly ... |
41725245 | Plant-Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors. | Potato virus X (PVX), a filamentous, positive-sense RNA plant virus, has been engineered into a molecular tool for diverse biotechnological applications, including cancer cell targeting. Here, we present the production and functional characterization of genetically-encoded PVX-derived nanoparticles decorated with nanob... |
41725239 | Pt@FeMOF-PEG Nanozyme-Mediated Reactive Oxygen Species Scavenging and Reduction of Treg Cells To Treat Surgical Trauma. | Postoperative immunosuppression, which is closely associated with the oxidative-stress-driven expansion of regulatory T cells (Tregs), increases susceptibility to severe postoperative outcomes, including infectious complications, multiple organ dysfunction syndrome (MODS), and tumor progression. Here, we report a zirco... |
41725161 | Diabatization with Electrostatic Embedding for Studying Photophysics in Organic Molecular Crystals. | Highly emissive organic molecular crystals find applications in several areas, such as organic electronics, solar cells, and sensors. Understanding the excited-state mechanisms underlying these applications is essential for optimizing and controlling them effectively. Exciton models coupled with nonadiabatic dynamics, ... |
41725138 | Integrating Self-Assembled Alkylthiol-Modified Metal-Organic Framework Nanoparticles with U-Shaped Tapered Optical Fiber for Volatile Organic Compound Sensing. | Self-assembled nanoparticles (NPs) demonstrate significant promise in various fields, such as display, substance detection, and sensing applications. Their structural tunability, high specific surface area, and pronounced interfacial effects make them suitable for fabricating high-performance sensors. However, the fabr... |
41725141 | Constructing N, O-Coordinated Metal Sites on β-Ketoenamine Covalent Organic Frameworks to Promote Photosynthetic Hydrogen Peroxide Production. | Covalent organic frameworks (COFs) represent crystalline organic semiconductors with exceptional potential for artificial photosynthesis. Their highly regular structures, inherent porosity, and abundant coordination sites make COFs ideal substrates for anchoring single metal atoms that facilitate photogenerated electro... |
41725132 | An Integrated 3D-Printed Portable Device Coupling Bimetallic FeCo-MOF Nanozymes with Freeze-Dried Hydrogel Carriers for Point-of-Care Testing of Serum Acid Phosphatase. | Acid phosphatase (ACP) is a key biomarker for prostate disorders, hyperparathyroidism, and other metabolic diseases. However, current ACP assays are limited by complex protocols, bulky instrumentation, and poor stability under resource-limited conditions. Herein, we report a portable, smartphone-readable point-of-care ... |
41725016 | Uncovering a novel role of otu in lepidopteran Bombyx mori male fertility. | <h4>Background</h4>Male infertility has emerged as a global concern, with dysfunctional spermatogenesis being a major cause. A significant proportion of agricultural pests belong to lepidopteran species, making it valuable to explore the conserved genes involved in spermatogenesis within the lepidopteran model, Bombyx ... |
41724980 | UVI5008: the first reversible, non-covalent Bruton's tyrosine kinase epi-inhibitor for B-cell malignancies. | <h4>Background</h4>Chronic lymphocytic leukemia (CLL) can still be a therapeutic challenge; notwithstanding substantial progress in therapeutic approaches with small molecule inhibitors, the emergence of inhibitor resistance and suboptimal long-term outcomes highlight the persistent need for novel, more effective treat... |
41724972 | Electro-controlled assembled of biphasic guided bone regeneration membrane for healing of diabetic periodontal bone defects. | <h4>Background</h4>Regeneration of periodontal bone defects has long posed a significant challenge to clinicians. Traditional guided bone regeneration (GBR) membranes have a single function, making it difficult to achieve immunoregulation and bone regeneration under the inflammatory and infection-prone conditions of di... |
41723834 | Recent Advances in Moisture-Electric Nanogenerators: From Moisture-Enabled Electrification to Practical Applications. | The global energy shortage continues to raise energy prices and cause an imbalance between supply and demand of oil, gas and electricity. This ongoing worldwide energy crisis highlights the urgent need for exploiting more renewable and clean energy from natural resources while simultaneously minimizing the carbon footp... |
41723826 | Construction of an Al-Based MOF with Methyl-Functionalized Microporous Nano-Traps for Efficient Separation of SF<sub>6</sub>/N<sub>2</sub>. | Sulfur hexafluoride (SF<sub>6</sub>) is indispensable to the power industry, yet its emission requires strict control due to the potent greenhouse effect. The direct recovery of high-purity SF<sub>6</sub> from industrial waste gas is vital for sustainable use but remains a formidable challenge. Herein, we report NU-62,... |
41723749 | Seasonal changes in energy intake and emerging indicators of energy availability in young elite Nordic skiers. | <h4>Background</h4>Nordic skiing, an energy-demanding endurance sport, may be particularly susceptible to low energy availability (LEA) and relative energy deficiency in sport (REDs). The objective was to examine the nutritional practices and physical symptoms associated with (REDs among young elite Norwegian Nordic sk... |
41723736 | Self-Assembled Ionic Clusters Accelerate Li-Ion Transport Through Microphase-Separated Polyelectrolytes. | Precise, molecular-level control of ion coordination and mesoscale morphology is essential for pushing solid polymer electrolytes toward the conductivity and mechanical robustness metrics demanded by next-generation batteries. Here we introduce an elastic microphase polyelectrolyte (EMP) whose thermodynamically driven ... |
41723708 | Frontier Progress and Fundamental Hurdles: A Perspective on the Evolution of Metal-Organic Framework/Wood Composites. | Metal-organic frameworks (MOFs), as a class of advanced porous materials with tunable functionalities, have demonstrated exceptional application potential across various fields. Wood, a natural and green material featuring hierarchical pore structures and abundant functional groups, offers an ideal three-dimensional st... |
41878175 | A Case of Toxic Epidermal Necrolysis-Like Dermatosis Associated With Contact Exposure to a Flurbiprofen Plaster. | Topical nonsteroidal anti-inflammatory drug (NSAID) formulations are widely used for the management of chronic musculoskeletal pain and are generally well tolerated. Severe cutaneous adverse reactions to topical agents are rare. We report a case of toxic epidermal necrolysis (TEN)-like dermatitis arising from contact d... |
41800360 | Multicomponent Oxicam-Metformin Salts: Toward a Strategy for Enhancing Solubility and Stability. | Drug-drug pharmaceutical multicomponent materials (PMMs) offer a promising strategy to modulate the physicochemical properties of active pharmaceutical ingredients, while enabling synergistic effects and combination therapy. Here, we report the preparation and full characterization of a new family of oxicam-metformin (... |
41800284 | White Vortex Light Generations With 7OCB Spherulite. | A spherulite is a radially symmetric, microscale crystalline aggregate formed by molecular self-assembly, typically exhibiting concentric birefringent textures under polarized light, which is highly sought after for optical applications, especially in structured light generation and modulation. In this work, we exploit... |
41775159 | Identification of central regulators related to residual feed intake in Huainan chickens based on weighted gene co-expression network analysis. | The residual feed intake (RFI) is a crucial economic trait in chickens. However, the genetic network and regulatory mechanisms that underpin RFI traits and the effects of RFI on meat quality and slaughter performance in chickens remain unclear. In this study, a total of 315 male Huainan chickens were reared from 7 to 1... |
41771216 | Quantitative analysis of cyclosporine A in whole blood samples of liver transplant recipients using a stir bar-assisted magnetic dispersive solid phase extraction combined with HPLC-MS/MS. | Cyclosporine A is an immunosuppressive drug which is used in the organ transplantation and treatment of autoimmune diseases. Also, it has been approved to be used as a hepatoprotective agent in the liver transplant recipients. Nephrotoxicity is the major toxic side effect of cyclosporine and due to its narrow therapeut... |
41767949 | Prokaryotic defense systems: Diversity and evolutionary adaptation. | Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long-standing co-evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these systems, highlighting their diverse antiviral mechanisms across d... |
41755006 | Non-Viral Nanovectors Based on Cyclodextrins for siRNA Delivery: An Update to Current Technologies. | Gene delivery/administration and, in particular, small interfering RNA (siRNA) delivery represent a therapeutic challenge, though very effective carriers have yet to be identified. Cyclodextrins (CDs) are cyclic oligosaccharides with unique host-guest inclusion capabilities, widely recognized in the pharmaceutical fiel... |
41752516 | Rational Design of PCN/Ce-MOF S-Scheme Heterojunction for Highly Efficient Synergistically Photocatalytic H<sub>2</sub> Evolution and Tetracycline Degradation. | Catalytic systems that couple pollutant degradation with hydrogen evolution have attracted significant attention due to their potential to simultaneously address environmental and energy issues. In this study, an S-scheme heterojunction composed of lamellar polymeric carbon nitride (PCN) anchored with a rod-like cerium... |
41740351 | Characterization of 3-ketosteroid Δ<sup>1</sup>-dehydrogenases (KstD4&5) of Mycobacterium neoaurum and their effects on phytosterol transformation. | Mycobacterium neoaurum can convert phytosterols (PS) into steroidal intermediates such as HBC (22-hydroxy-23,24-bisnorchol-4-ene-3-one). However, 3-ketosteroid Δ<sup>1</sup>-dehydrogenase (KstD) can catalyze the dehydrogenation at the C1 position of the steroid nucleus, which leads to the accumulation of byproducts suc... |
41745194 | Upconversion Luminescence of NaYF<sub>4</sub>:Ln<sup>3+</sup> Nanoparticles on Gold Nanorod Array with Dual-Wavelength Excitation. | Plasmonic nanostructures have been widely employed to improve upconversion luminescence performance; however, their impact on excitation pathways under multi-wavelength excitation is not yet fully understood. In this work, we constructed hybrid systems composed of gold nanorod arrays and NaYF<sub>4</sub>:Yb<sup>3+</sup... |
41745054 | Alginate-Based Hydrogels: Recent Progress in Preparation, Property Tuning, and Multifunctional Applications. | Alginate-based hydrogels, derived from brown seaweed, represent biocompatible and biodegradable materials whose properties are systematically controlled through molecular structure (M/G composition), crosslinking strategy, and compositional modification. This review synthesizes recent advances in alginate hydrogel desi... |
41744901 | Analytical Performance of Nanobody-Based Immunoassay and Immunosensing Platforms for Bacteria and Toxin Detection: A Systematic Review. | <b>Background:</b> bacterial pathogens and their toxins present analytical challenges for rapid and specific detection, contributing to over 600 million cases of illness annually and worsening antimicrobial resistance (AMR). Conventional detection methods are useful but limited. Single-domain antibodies (sdAbs) offer a... |
41734598 | Post-column derivatization high-performance liquid chromatography-ultraviolet-ultraviolet (HPLC-UV) method for the detection of Kryptofix 2.2.2 content in Positron Emission Tomography (PET) tracers. | A post-column derivatization high-performance liquid chromatography-ultraviolet (HPLC-UV) method was developed to determine Kryptofix 2.2.2 (K2.2.2) in PET tracers. This method utilizes the specific complexation between K2.2.2 and Pb<sup>2+</sup>, forming a stable 1:1 host-guest complex. The complexation produces a bat... |
41734423 | Platinum nanozyme logic gates for probing biomolecular recognition and interaction dynamics. | Recent studies have suggested that primitive catalytic systems resembling nanozymes may have played a role in the emergence of biochemical complexity during early molecular evolution. Bridging this conceptual link between abiotic catalysis and biological information processing, platinum nanozymes supported on graphene ... |
41730466 | Emerging nanocarrier platforms in Cervical cancer therapy: From Molecular targeting to Precision Nanomedicine. | <h4>Background</h4>Cervical cancer being a significant global health burden, for which conventional treatments like surgery, chemotherapy, and radiotherapy are limited by poor tumour specificity, systemic toxicity, infertility, and compromised long-term disease control. These limitations highlight the need for advanced... |
41730446 | Quaternized chitosan-g-polyaniline (QCSP)-based versatile immunomodulatory conductive supramolecular hydrogel with controlled Zn<sup>2+</sup> release for functional healing of infected burn wounds. | Burn injuries are prone to life-threatening complications due to bacterial infection, excessive oxidative stress, and persistent inflammation, often culminating in scarring that impairs skin barrier function, causes limb constructure, anhidrosis and sensory deficits. The critical challenges in burn wound management inc... |
41730380 | Comprehensive identification of emerging contaminants in drinking water from 12 countries combining supramolecular solvent extraction and suspect screening analysis. | Technological and industrial development has led to the release of thousands of emerging contaminants (ECs) into the environment. Many of these compounds persist in the water cycle and reach drinking water supplies due to their inefficient removal during conventional treatment. Given the potential risks of chronic expo... |
41730385 | An in-silico study exploring the differences between the G protein of Chandipura virus isolates with respect to their antigenic sites and their interaction with vimentin. | <h4>Purpose</h4>Chandipura virus (CHPV), belonging to the Rhabdoviridae family, is an emerging pathogen linked to encephalitis outbreaks, especially in children under 15 years of age. CHPV is primarily spread by sandflies and has led to several outbreaks in India, but CHPV strains from African nations namely Senegal, K... |
41723543 | Epigenetic modulation to overcome immune suppression in pancreatic cancer. | Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, primarily due to its highly fibrotic and immunosuppressive tumor microenvironment (TME), which limits both drug delivery and immune cell infiltration. Epigenetic dysregulation plays a pivotal role in shaping these barriers by controlli... |
41723501 | Silver nanoparticles-based green fluorescent probe for determination of Bosentan in pharmaceutical formulation and spiked plasma samples. | In this work, a new, sensitive, precise, accurate, and eco-friendly spectrofluorometric method for the detection of Bosentan in human plasma and pharmaceutical dosage form was developed, using silver nanoparticles (AgNPs) as an efficient fluorescence sensing probe. The general concept used in this approach is based on ... |
41723494 | Coordination versatility and enhanced bioactivity of Co<sup>2+</sup>, Cu<sup>2+</sup> and Cd<sup>2+</sup> complexes derived from pyridyl Schiff base: structural, electronic and electrochemical insights. | A Schiff base ligand, H<sub>2</sub>L, was obtained from the condensation of pyridine-2,6-dicarbohydrazide and cinnamaldehyde and was further complexed with Co<sup>2+</sup>, Cu<sup>2+</sup>, and Cd<sup>2+</sup> ions. The coordination complexes were then analyzed by normal spectroscopic/microscopic analyses (FT-IR, UV-vi... |
41723481 | Rationally designed thiazole-based COF with multiphoton activity for drug delivery and synergistic therapy of deep-seated tumors. | Multiphoton absorption photosensitizers (MPAPSs) activated by near-infrared light have attracted considerable attention in the fields of homogeneous photocatalysis, optical imaging, and phototherapy because of their negligible interference, low dilapidation, and deep penetration. Nonetheless, most MPAPSs still face iss... |
41723420 | The emerging pathogen Candida auris: host interactions and disease drivers. | Candida auris has emerged over the past fifteen years as a multidrug-resistant human fungal pathogen responsible for hospital-acquired infections associated with high mortality rates. Clinical isolates frequently exhibit resistance to one or more first-line antifungal drugs, and management is further complicated by per... |
41723417 | Electron transfer-driven nanozymes integrated "colorimetric-photothermal" nanobody-immunosensing for tropomyosin inspection. | <h4>Background</h4>Tropomyosin (TM) is a major and highly stable allergen in crustaceans such as shrimp. The high stability of TM during food processing or gastrointestinal digestion impels the substantial allergenic risk to sensitive individuals, which strengthen the urgent requirement of rapid and sensitive detection... |
41723374 | Transcriptome analysis of hormone-related genes in winter rapeseed treated by different photoperiods and vernalization times. | <h4>Background</h4>Winter rapeseed is an important oilseed crop in northern China which needs to experience low temperature for a long time during the overwintering period. Come March of the next year, new leaves grow from the growing point and it enters reproductive growth. For this reason, strong winter rapeseed can ... |
41723341 | A target-guided drug repurposing strategy for antibacterial discovery. | <h4>Background</h4>The scarcity of effective antibiotics against drug-resistant pathogens has intensified the need for alternative antibacterial development strategies. Drug repurposing (DR) offers a practical solution; herein, we present detailed experimental workflows and in vitro results to validate the feasibility ... |
41723337 | Electrodeposition preparation of Ni/Co-MOF/MXene heterojunction to fabricate enzymatic electrochemical biosensor for detecting trace urea. | This work develops an in situ electrodeposition strategy to construct a honeycomb-like Ni/Co-MOF/MXene heterojunction directly on the glassy carbon electrode (GCE) surface at -1.3 V vs. Ag/AgCl, enabling ultrasensitive enzymatic electrochemical detection of trace urea. The high catalytic activity of Ni/Co-MOF and the s... |
41723205 | A Unified Dataset for Antibody and Nanobody Design Including Sequence, Structure, and Binding Affinity Data. | The design and optimization of antibodies and nanobodies using deep generative models hold transformative potential for therapeutic and diagnostic applications, which are hindered by the fragmented and inconsistent nature of existing datasets. To address these limitations, we introduce the Antibody and Nanobody Design ... |
41723195 | Engineering biomimetic chloride channels in ultramicroporous hydrogen-bonded organic framework membranes for high-salinity wastewater valorization. | Biological ion channels exemplify nature's high-efficiency ion selectivity filters, yet replicating their functional architectures in synthetic membranes remains a fundamental challenge. Here, we report an ultramicroporous hydrogen-bonded organic framework membrane that structurally emulates the CLC chloride filter. It... |
41723144 | Photooxidative Copper(II) Catalysis for Promoting anti-Markovnikov Hydration of Alkenes. | Photoredox catalysis enables the generation of radical intermediates under mild conditions, yet photoredox catalysts have heavily relied on precious transition metal complexes. Therefore, the development of photocatalysts based on earth-abundant metals is increasingly demanded. Here, we report a highly photooxidative c... |
41723147 | Soft photo-ionotronics. | The ability to control the movement of charged species in the circuitry of living beings and machines is essential for complex signal processing, computation, and, ultimately, higher functionality. We describe a class of photo-ion generators (PIGs) based on non-ionic photoacids that can create large (> 1000x) irreversi... |
41723139 | Light-induced assembly and repeatable actuation in Ca<sup>2+</sup>-driven chemomechanical protein networks. | Programming rapid, repeatable motions in soft materials has remained a challenge in active matter and biomimetic design. Here, we present a light-controlled chemomechanical network based on Tetrahymena thermophila calcium-binding protein 2 (Tcb2), a Ca<sup>2+</sup>-sensitive contractile protein. These networks-driven b... |
41723131 | Photocatalytic four-component reaction to access covalent organic frameworks for photocatalysis. | Photocatalytic four-component reaction is an efficient and environmentally friendly synthetic strategy known for its step economy and operational simplicity, enabling the preparation of diverse organic products. However, its application in synthesizing covalent organic frameworks (COFs) remains unexplored. Here, we rep... |
41723128 | Guest-induced porous gating of a fluorescent nonporous adaptive crystal for efficient radioactive iodine sorption. | Nonporous adaptive crystals (NACs) are a new class of organic adsorbents that benefit from the ability of their crystalline structures to adaptively transform in response to specific guest molecules. Herein, a NAC with guest-induced porous gating property is demonstrated within a small organic molecule, BiPyBz. It prod... |
41723118 | Exploring chemistry and catalysis by biasing skewed distributions via deep learning. | The automated discovery of chemical and catalytic reactions remains a major challenge in computational chemistry, particularly in complex systems where conventional methods struggle to identify optimal searching directions. Here, we propose Loxodynamics, a machine-learning-driven approach for reaction exploration via b... |
41723116 | Redefining catalyst reconstruction and Cl<sup>-</sup>-repulsion correlation to delineate a dynamic protective skeleton for seawater splitting. | From the perspective of sustainable energy and green hydrogen, the critical challenge in seawater electrolysis lies in suppressing competitive chloride oxidation and corrosion at the anode. Despite the proposed protection mechanism based on surface reconstruction-derived anion repellence, a fundamental question of sele... |
41723109 | A strategy for biomass-derived matrix with facile moulding and closed-loop recycling capabilities. | Developing polymer matrices with closed-loop recyclability is a key solution to solve the sustainability issues caused by unrecyclable end-of-life multi-phase composites, and using building blocks from renewable resources rather than petrochemical products presents an attractive option. However, the strategy of first e... |
41722062 | Magneto-X Effects in Magnetic Soft Materials and Their Applications. | Magnetic soft materials (MSMs) represents an emerging class of composite materials that integrate magnetic responsiveness with the mechanical compliance of soft polymers, gels, and fluids. This review systematically summarizes the fundamental magneto-responsive effects-including magnetorheological, magnetoelastic, magn... |
41721784 | Lanthanide metal-organic Framework Fluorescent Sensor for the Detection of Furazolidone in Tap Water and Animal Feed. | The illegal use of furazolidone (FZD) in livestock and aquaculture results in FZD residues in related products, posing significant health risks such as carcinogenicity and teratogenicity. Accordingly, there is an urgent necessity to develop advanced analytical sensors for the detection of FZD residues. In this study, a... |
41721763 | Orally Bioavailable Cyclin A/B RxL Inhibitors: Optimization of a Novel Class of Macrocyclic Peptides That Target E2F-High and G1-S-Checkpoint-Compromised Cancers. | Cyclins A and B bind and activate their cognate cyclin-dependent kinase (CDK) to regulate progression through the S and G2/M phases of the cell cycle, respectively. Cyclins recruit substrates and regulators through the binding of an RxL motif with a Hydrophobic Patch (HP) on the cyclin surface. We recently disclosed th... |
41721613 | Tailoring Electronic Properties of Precision Graphene Nanoribbons via Nanopore Engineering. | The precise incorporation of nanopores into graphene nanoribbons (GNRs) offers a complementary strategy for modulating their opto-electronic properties beyond conventional width and edge engineering. However, a systematic understanding of the relationship between the structure and electronic properties of porous GNRs (... |
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